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<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5S6</accession>
    <name>A0A7K2Z5S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase sulfur carrier subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="9683" checksum="19DA7C3F0DF4972E" modified="2021-04-07" version="1">MSVKVRIPTILRTYTGGQAEVTAEGAKLSEVIESLEKDHPGIAARVLDDQGKLRRFVNVYVNDDDVRFEGGLDAATPDGAGISIIPAVAGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z610</accession>
    <name>A0A7K2Z610_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000013">
        <property type="protein sequence ID" value="MYW27779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="19160" checksum="79D337C21310B8D5" modified="2021-04-07" version="1">MTTLFLMVGLPGAGKTTRARQLAEQHGALRLTPDEWMLPLFGEAEADGKRDVLEGRMLWLALEAVKVGTSVVVDYGCWSRDERSAIRWLAEAAGARFRLVYLPVDAETQRARIAHRRATAAGETFPMTEADILHGWAQFEEPDAAELEGGALSGPPPGWAGWREWAAARWPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Q5</accession>
    <name>A0A7K2Z6Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000073">
        <property type="protein sequence ID" value="MYW28025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="6331" checksum="F54647E5199F62EE" modified="2021-04-07" version="1" fragment="single">MPATTKRQVHLAAQLPGIHNVTAWSDPRSESQISIDSFIRLAQTVERGKFDFFFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6S4</accession>
    <name>A0A7K2Z6S4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000080">
        <property type="protein sequence ID" value="MYW28046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511314.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000080.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6576" checksum="324C0A120FC474F1" modified="2021-04-07" version="1">MTHISESAIQGSGNLAHEGAYDHPAGQISLGIGGGLGMRSRLLSASEGETGNTIDLPWTTMIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z719</accession>
    <name>A0A7K2Z719_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Type VII secretion protein EccB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">eccB</name>
        <name evidence="12" type="ORF">GT040_02210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000101">
        <property type="protein sequence ID" value="MYW28115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW28115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="508" mass="53831" checksum="1FF07CD7425FA9DB" modified="2021-04-07" version="1">MASRRDELNAYTFAKRRLIAQFLQPNPTGSEEGAPRPLRAVVPGAIIGVVVLAVFGAWGMFKPVAPKDWDTPNENVIIASKSTTRYVVLTTDGKKQLHPVLNMSSAKLLLAQDKGKVVNVDESVLDNGTIPHGATLGIPYAPDRLPDPKDAGSAKRWAVCEQPGEGGRAIQKAAFVLAEREEEKTEGTAKLRGGEVMYVEGPDRTRYLVDATGKAYPVPVDELLLRTLVDPGAKPQRVSAAWLATLHQGDRITFPTLDGVPGSPANVPGTLDDDTDKVGMVLAATAGTRTQQYVVLPGRVAPVSDFIAKLLLSSRDLDKLGQAGQVKPVGASAFSPGRAFGAELDWPVHEAKAVNSPDVTKGGRNTVCNVLRDVDADNGATTLSTWVGTGFPATLPTGSSSAYVTPGSGEFFRQFQGSQTDVGFLFLVTDTGLRYAMQSNSDSGQDDSGIGASGSKKEREARRQEAQQAQNLLGYKDVDPTPVPAAWSTFLPTGPRLSTGAASQPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z725</accession>
    <name>A0A7K2Z725_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">GT040_02225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="WWKE01000102">
        <property type="protein sequence ID" value="MYW28118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030563669.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000102.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="24835" checksum="5B93AE3C20ED29A4" modified="2021-04-07" version="1">MVNTHMNNFPGASASGLYTGPQVDNRYVVPRFVERTSQGVREYDPYAKLFEERVIFLGVQIDDASANDVMAQLLCLESMDPDRDISIYINSPGGSFTALTAIYDTMQFVKPDIQTVCMGQAASAAAVLLAAGTPGKRMALPHARVLIHQPSSQTGREQLSDLEIAANEILRMRTQLEQMLARHSTTPLEKISEDIERDKILTAEDALAYGLVDQIVSTRKTTAGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7B2</accession>
    <name>A0A7K2Z7B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000115">
        <property type="protein sequence ID" value="MYW28208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="88" mass="9124" checksum="5A5228B2CF77A35D" modified="2021-04-07" version="1" fragment="single">MTVEGTVSGLEERLVGRAWMVRLDPADRGGAAVRVSCGRPACAPQVLPSATVGRTAAVAHLATHLRAAPGPRPEASCACRAEECHTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7C7</accession>
    <name>A0A7K2Z7C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_02730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000116">
        <property type="protein sequence ID" value="MYW28213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="28119" checksum="4E3E230128D4C98E" modified="2021-04-07" version="1">MATPVTISTETILAAQGGDADAMWQIVSAYEPMLKSVVRSVAPAASADTSEDLLQEARAVLIQHVRAYSTETDSAQLHSFAYRAIRRAVAEEWLRSTTSLSVDPSAALAVRRALWTTEGDVEGAWMIVSSVADPRRRMSREAFVSMCEALTDVMSLEGPTGGTDGDGNGQTLADTIPDASSTFTDATERRDLARYLLSEIPQRRAYALRAFYGIGMQTRTDQEVAADLDVRPGGVRVLRSQGLDSARKVANRFELRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z812</accession>
    <name>A0A7K2Z812_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000192">
        <property type="protein sequence ID" value="MYW28489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="371" mass="39774" checksum="E71D41AB77FA340B" modified="2021-04-07" version="1">VAARTRPARPRTGHSLKAGSPDVSSFPRTAWLRAARKALTAAPDEVFDYGDPRGRVELRTVLAEYLARSRGVYADPERIVICSGFVHGLMLLGTVLRGRRVRELAVESYGLGLHRDLITSTGLATPCLELDHLGSRTGELAAMRGTGAVLLTPAHQFPTGVPLHPDRRAAAVDWARSTGGLVLEDDYDGEFRYDRQPVGALQGLDPERVVYCGTASKSLAPALRLGWMVLPRGLVAEVLAAKGPSDSMSGTLDQLTLAEFIASGAYDRHVRSMRLRYRRRRDQLVAALAERAPGIEVSGIAAGLHAVLELPPGTERSVIQAAAFQGLRLEGLATYRHPGAPVGRDALVIGYGSPSESAWAGALDALCRVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z837</accession>
    <name>A0A7K2Z837_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000180">
        <property type="protein sequence ID" value="MYW28473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="18589" checksum="04DF72451D771CFD" modified="2021-04-07" version="1">VRPPRWAAEEGDGSWPTGGRANVDVPGSGAFALIPGTTVDNVPRALTSTPVGRIVAEADRPGSVVIVLAPPVLSYADAVALVDRVEGVMIVCDPRAVHRSDLERIREIIGASGGSVLGALLHPGRRRLTRSERHPKSARRRTGGGGGPAPAAEPDAPEITGDPTETLGLRSLTLPAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8A3</accession>
    <name>A0A7K2Z8A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coagulation factor 5/8 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000203">
        <property type="protein sequence ID" value="MYW28571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029779535" evidence="1">
        <location>
            <begin position="46"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="43"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="36614" checksum="69FCD9618D31F7CA" modified="2021-04-07" version="1" fragment="single">MSVALVRPSRPPMAALHRWRALGFALVTALVAALLGVVQAAPAQAAPVLLSQGSPATASSTEGPFAASNAVDGNAGTRWSSAFSDPQWIRIDLGSPAALSRVELAWEAAYAKSYRIELSTNGTTWTNAYSTTTGQGGNETLTVSGEARYVRLTGTQRATGYGYSLWEFKVFGTRDGGGGPQIPGGGDLGPNVHVFDPSTPNIQGKVDEIFRQQESAQFGSGRHALLFKPGTYNNINAQIGFYTQIAGLGLNPNSTTFNGDVTVDAGWFNGNATQNFWRSAENLTLNPVNGTNRWAVSQAAPFRRMHVKGGLNLAPDGYGWASGGYIADSKIDGTVGPYSQQQWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8L3</accession>
    <name>A0A7K2Z8L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_05260</name>
        <name evidence="8" type="ORF">GT040_20325</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000245">
        <property type="protein sequence ID" value="MYW28690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01000964">
        <property type="protein sequence ID" value="MYW31558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="234" mass="24139" checksum="C85966EF6F3AA4DC" modified="2021-04-07" version="1">MPQNSGPEGPSEPLTTDAVTRIVLRPIASPLPLGFFALGMGSTVLSSLQLGWVPIAQSGILLLLVLIFVVPLQLVGGVFAFLARDAGAGTALLLLGAAWAGTSVTSLDSPPGKPVVAQAVFLLALVPFVLALAGAAAQSKPLFAVLLTLTAVRFALTGLYEAGLGNALQVAAGWTGLGIGVFALYGGLALLVEDGKQRTVLPLFRRGKARESIEGDLREQLTEAQQEAGVRHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Z2</accession>
    <name>A0A7K2Z8Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone Hsp90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000257">
        <property type="protein sequence ID" value="MYW28817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="663" mass="71009" checksum="3195F79AE39C40F1" modified="2021-04-07" version="1">FLEPAAPGDPEAEPRWADDWDRDRTDESTATTALRPVEAEVVEGVGAETVRVLAEVLPCLLPAGLERRPELRTLGVARVPLTEAIDRLAGLERDPAWWHRLYDSLAGIDPDRLTGLPVPLAGDPEDERAGRLPRTTIGPRQVLLPLPDALTGPVLSRLSRLGLKVAHPDAAHPLLEKLGALPATPRAVLTTPQVRAAVAGSLDAGEIWDEDALDGDELAETVLTLVRDAELVPGDEPWLGALALPDEEGEPAPAGELVLPGSPFAQIMREGELALVDEELADRWGEAPLTACGVLATFALVRATDVVLDPDELEPRDSDFAEPDDAGLLDAVDVWCEDLLDQLPETPVPPVATEIVAVRDLDLVDDDAWPQALAMLAQPPLRDALTQPVRVLLPDGTTQSVRPYTAWWLRDHPVLDGRRPAGLRSAGGDPVLAGLYDAVDATGFDDAQVLRALGVRTSVAALLDEPGGAAELLGRLADEDRPVAPVQLHALYTALAELNPEQVTLPDELRAVVDGDVTVVDAADAVIADAPDVLPLTEGLPLLPVAPARAAELADLLQVRRLGESVEAGVESEGEEHRVPESVRVLLGPATPDTYIEHSELRAGGVELDWRRTRDGVVHASTLEGVAAGLAWAAGQWPRRFEVAALLEDPSRTEELARDRWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9A6</accession>
    <name>A0A7K2Z9A6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_06595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000300">
        <property type="protein sequence ID" value="MYW28950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="20711" checksum="BBF11443CAA4C9A0" modified="2021-04-07" version="1">MNHPHSNPPGKLGTLTVRPLDPACDAELVHGWVTHPKAAFWLMGEAKLEDVEREYRAIAAHPHHDAFIGLHDGEPAFLIERYDPTEVELKGLYEAEPGDAGMHFLVAPTDTPVHGFTRAVITAVMEFLFADPSVRRVVVEPDVTNSAVQALNKAVGFEVLREIAKPEKDALLSACTREQFEAATGGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9C8</accession>
    <name>A0A7K2Z9C8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glsA</name>
        <name evidence="7" type="ORF">GT040_06655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="WWKE01000301">
        <property type="protein sequence ID" value="MYW28961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="322" mass="33433" checksum="8F861DAD90694AB5" modified="2021-04-07" version="1">MSHTSAAARATSPAPPSGSHRFSSVINQIAEEMQTLDDHGTPADYIPMLADADPRRFGLAVAEPDGTVYGVGDWRQPFSTQSISKVFALALALSLDGGQLWRGVGREPSGNPFNSLVQLEYENGIPRNPFINAGALVVTDRLQALTGDAAGQVRDLLRTESGNAAIDFVPQVAASEAAFGDRNAALAHFMASYGNITLPVPALLAAYFRQCSIEASCADLALAAGFLARGGVRADGSALLTRSQAKQVNAVMLTCGTYDAAGEFAYRVGLPGKSGVGGGIIAIVPGVCTLCVWSPGLDKRGNSVAGVSALDRFTTLTGLSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9K0</accession>
    <name>A0A7K2Z9K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000311">
        <property type="protein sequence ID" value="MYW29019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="24171" checksum="C8FD72D2BF3B2932" modified="2021-04-07" version="1">MSAWLKDETTLQAGGAAAPHAVDIFALLRDQTGAQAAQVTAAGAAWLAGASAYPRSTLAQWEERPASPGVLPCGSQFDVVNVPALFGRRMLERLWAEGPGTGPVAVHRGRMLLFAAPGTAQRLPSLLAWEEWGSGDDQASRPQRGEVPPLLCHGTGDAVTVPPLTCPSGGSGPRWLVAPDTRNPWLPGPDVLLWACVRVSRSAVSQGSGHSIFPRADQGANVYDVSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9V7</accession>
    <name>A0A7K2Z9V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000320">
        <property type="protein sequence ID" value="MYW29055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029579936" evidence="2">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="18115" checksum="D2B0F2CA5A3A7413" modified="2021-04-07" version="1">MTKLLLSLHVLASILAVGPITVAASMFPRYAKPPAPGDDGPHDHDLRTAAFLHKICRGYAVVGIAVPVLGLATGAQMGVLGDAWLVASIVLTTIAAALLMSMVLPGQRELLEEEGEGEHLSGTGAGQGALGTGAGSGALTVAARRSAAARLAMTTGIFNLLWATVVVLMIVRPGSTTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Z3</accession>
    <name>A0A7K2Z9Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="17383" checksum="18D0E7CDA362766F" modified="2021-04-07" version="1">MDAPPRWLTPEQQAAWDSFIRMQEKLIGRLSRQVQADSRMSPADYIVLAKLTEAGGRMRLTDLAKLVEWEKSRMSHQVGRMAKRGLVAKEDCPDDGRGAFIVATPAGREAIEEAAPVHVEHVRRLFVDALTPEELDTLARISDRVLAHMERQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA04</accession>
    <name>A0A7K2ZA04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000357">
        <property type="protein sequence ID" value="MYW29163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023934">
        <property type="entry name" value="LLM_FMN-dep_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04036">
        <property type="entry name" value="LLM_CE1758_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="366" mass="40872" checksum="1EF85D4D9F84216F" modified="2021-04-07" version="1">MQFGIFTVGDVTTDPTTGRTPTENERIKATLAIARKAEEVGLDVFATGEHHNPPFVPSSPTTTLGYIAARTENLILSTSTTLITTNDPVKIAEDYATLQHLADGRVDLMMGRGNTGPVYPWFGKDIRQGIPMAIENYALLHQLWREDVVDWEGKFRTPLQSFTATPRPLDGVPPFVWHGSIRSPEIAEQAAYYGDGFFHNNIFWPMEHTKKMVDLYRRRYAHYGHGTAEQAIVGLGGQVFMRKNSQDAVREFRPYFDNAPVYGHGPSLEDFTRETPLTVGSPQEVIERTLTFRDAVGDYQRQLFLMDHAGLPLKTVLEQLDILGEEVVPVLRKEFANLRPAGVPESAPLHPAVAAARTTRAARKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA48</accession>
    <name>A0A7K2ZA48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000363">
        <property type="protein sequence ID" value="MYW29208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="13757" checksum="499BB74E58B21AFF" modified="2021-04-07" version="1" fragment="single">MRGVIELLEVYWTRVPEGFSPVTVSAPQLRVMYVIERREGINLRQLGAELDAAPSSVSRLCDRLEAIGFVRRSSSTASRREVELRLTAQGRAHLDRLRARREERLAAALARASPASRARLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA52</accession>
    <name>A0A7K2ZA52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000369">
        <property type="protein sequence ID" value="MYW29230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="54" mass="6110" checksum="63F9E250151A65F7" modified="2021-04-07" version="1" fragment="single">MSTTERPRILVVGGGYVGLYAARRILKKMRYGEATVTVVDPRSYMTYQPFLPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAG0</accession>
    <name>A0A7K2ZAG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000397">
        <property type="protein sequence ID" value="MYW29319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="14269" checksum="719E27EC449C5C61" modified="2021-04-07" version="1" fragment="single">GFGRAARDRLGPVLEDAAGRTGETVWSVALIGDQVIVTDGRESSHPVRVALELGRTGPAHAGSGGLLLLSRMTADQVCALYPDEALEAVTPATLTSRTALLAELAVIRRRGHAVSRGASVAGMTTVAVALAGSSWRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAN0</accession>
    <name>A0A7K2ZAN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_08990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000411">
        <property type="protein sequence ID" value="MYW29410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="212" mass="22668" checksum="C78A88EF811E50AA" modified="2021-04-07" version="1" fragment="single">MELAELVGLRPFPAAGLLLGLTRRCPLRCGHCSTGSDLTVREEPDAGQLLRFVGSFTAENRPDVVLLTGGEPLLLPTLAGELAFLARRAGSRTAVLSGMFFARSKEIPPAILRAIAQVDHFSASLDVHHEREVARADVFRALHRIRDSGVSVSFHLTGTGAADPYLADITRAIDKEFGGRVPSLVNEVRPFGRAASWARPARTGPDPSAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAQ9</accession>
    <name>A0A7K2ZAQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="364" mass="39587" checksum="BD4EBA755AB64119" modified="2021-04-07" version="1">MQSWDEVGERIAEARLAADMSQGGLASEVGLDRTAIVRIEAGDRRVSALELSRLAQALGVPLAHFLSRPPTPIASRRAALEDVSDEATRASYRLDAWLEQHARHAHWLIAEGFLTPPQVDPSVQRAEGQVDPVALAVAARSALGRPSGPLGPMADVVEQLGLFLTVVDESAEGASLLQDGYGVAVISGQAQPGRRRWTAAHELGHHLLQDEYHSDAGVAASRDEREQQIDRFVEWFMLPAQDVERVWRDVTEATEVRPALLAMAAGYRVSWSAVVNRVRNLELIDSGEARRQKANSPTRGDFLAVLGEQPVPDLEPGATGKLWRKAVLSAWETGAITAPRAIELLYGALTVDELPTRALEEPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBK7</accession>
    <name>A0A7K2ZBK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="22456" checksum="37F435CBF44DE175" modified="2021-04-07" version="1">MRIVIAGGHGQIALRLERLLAARGDEAVGIIRNPQQSQDLTDIGAEPAVLDLESASVEETAEVLRGADAAVFAAGAGPNSGTARKDTVDRDAAVLFADAAQAAGVRRYIVVSSMGADPDHPGDEVFDVYLRAKGAADADVRSRSALDWTILRPGMLTNDAGKGQVLLAAKTGRGPIPRDDVAATILELLDTPATAGLTLEVISGNVPVTVSVKDVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBS3</accession>
    <name>A0A7K2ZBS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000493">
        <property type="protein sequence ID" value="MYW29762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="101" mass="10663" checksum="1A516EE21696B59D" modified="2021-04-07" version="1">MRAFYRGYSAATGRRAQQVRNLHVMREDGKFAGKQGLCGAPGWGVTHSPPVLIDPLPLAPPDGLVWCRSCVGHAAALVGQLDAFARIIAALNGLSGEEHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBT0</accession>
    <name>A0A7K2ZBT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_10865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000493">
        <property type="protein sequence ID" value="MYW29768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="604" mass="67014" checksum="26262C2094EA3C69" modified="2021-04-07" version="1">MWRVSLLERVTAKPLRQATAEWTTYTGTVWCPTVEHGTWLCRRKGLVHWTGNCGAGGSSQGAHSVPGVRVTRAANHWAKAIDSHEANFPEASHYRGDIRTAPVWDWPVTDIFWASPECTNWSVAKGKRRNFDTAMQGSLLDLLADQNEEEPADLEEESRALMEEVPLYLRGVQERGGLVKAGVVENVTDVRAWDQWDRWIGELHKMGYRTRIIALNSMHANPRSVHAAPQSRDRLYVGYWHESLGRTPDWDKWLRPRAWCSGCDTWVQAMQVFKTPGRDMGRYRTQYVYRCPSTTCRNQIVEPEALPAAAAIDWTIPGQRIGDRAKPLADKTIARIQAGLKKFSQPVPMMVPAGGTWRDTAVSVGEPMGARTTRENDGLMVPPLLIPVEGRDGKEARSVNDPLRTMTTRNETGLAWLPFIAELRGGGSIARSVTDALATVTASGNHHGLVMPELPAMVMRNNSASGDAGYLSTPVTEPVRALTTAGHQSLVTWNDILVPYYSNGTARTVREPIGALTTRDRYALVRGDVDINDVRFRMLEPHEIGRAMSFADDYIVLGSKRDKVRQYGNAVTPNAAEIILCALVEAVTGDELERYAEPQLAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC03</accession>
    <name>A0A7K2ZC03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000507">
        <property type="protein sequence ID" value="MYW29838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="63" mass="6104" checksum="523A568A60D26130" modified="2021-04-07" version="1">AVPPPALAGAQGAYLHPGNLTRLPGLYLAGGWSHPGGGLAHAGMSGTLVAGLVVEGDGFRGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC91</accession>
    <name>A0A7K2ZC91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000553">
        <property type="protein sequence ID" value="MYW29991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7520" checksum="A7AD76C502F23240" modified="2021-04-07" version="1">VVRLRHRIADELRAALIARGDPGLLADWAYSPWGEDDLAVWRALAGAAPAERRAAMLERVRGLDAEQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCJ6</accession>
    <name>A0A7K2ZCJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000586">
        <property type="protein sequence ID" value="MYW30076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="6776" checksum="EA79A22B6493E18E" modified="2021-04-07" version="1">VNTPYGTGGRLDGYEIRTAAVARSVPCLTTVQALAAAVQGIDALNGGDVGVRSLQEHAEHLTAARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCQ6</accession>
    <name>A0A7K2ZCQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="9975" checksum="C2FE099B3A1B26A1" modified="2021-04-07" version="1">MSARENLLNAVGFADAMNLGSEPEVLVDAYRTEVLADAADRIEQRAAQLDAGWLRADQIVDALRRLAEPMQAPRTQDGNGTLPTPRPETGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCU2</accession>
    <name>A0A7K2ZCU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000593">
        <property type="protein sequence ID" value="MYW30085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7292" checksum="940E51B42643C4D7" modified="2021-04-07" version="1" fragment="single">ELSRADAVDLEGLRARLAARTRPDEALRHADRAVRASLLTDSPLVQAAAELDRARTLAALDRTAAAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCV0</accession>
    <name>A0A7K2ZCV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000604">
        <property type="protein sequence ID" value="MYW30180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029517037" evidence="1">
        <location>
            <begin position="50"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="408" mass="43638" checksum="1530A6A66916544A" modified="2021-04-07" version="1">MPIRSHAPSAPAAGPTAAPATRRRVLAAALAVGAGIALATPLTAGTAAAASTTCLNGTLAFDHNDAEAGTHKPLVTQRARNSNWELWGRRTASGQVERLSSGLTGATDGRFSACHTGTAAPRDVHVRFFSSAGTLWRVVGAGTAKQGDPNWKNTTQYTFTTATRNTPAATTDLGTVKVPKAMQQAWKITDTLNQLYGKRGTGSLCWTAHQTSACDQLTVAWRQDGSSGGYWDHPSFPGDTSDGTDWVVLKADDPDSKHLILHEAGHWFQWQLHNKQWPPVRDCNGHSLDKGASAACGWTEGFANAVAAYALGDSRYTFSTGDSYDLLDQRVVGGWGKGDWVEGRVAAALLELWGPNGPDGGNWNRTLKLMNTYVSGDFKQYFTQHRPLAGLSTTGAAKTIINRNTIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCX2</accession>
    <name>A0A7K2ZCX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ketoacyl-ACP synthase II</fullName>
            <ecNumber evidence="5">2.3.1.179</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_12890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000600">
        <property type="protein sequence ID" value="MYW30158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="2"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="35093" checksum="08C77F34374AA31E" modified="2021-04-07" version="1">VAAQRLMDRFAQLAVIAAREAVADAGLDPALWDSGRVGIVIGSAHGGLPFYDEQHATLAERGARRVSPKLAPLSVVNGAASSVSLDLGVQGPSQAVSTACSSGTVAIGTAHQMLRSGACDIVIAGGAESTCTRLLIASACSLKAVSTRREDPTAACRPFDTHRDGFVVGEGAGLLVLEHPEHARARGATVRAHVNGYGASSDAHSAVAPDPDGLGIERALRTALADAGISPADVGHVNAHGTSTLSNDLIEATMLRRVLGESPLVTSTKAMTGHTLGAAGGIEAALTVLALQHQLVPPTVNLDAPDPQIEMNVVAKEARSASFDCAVKTSLGFGGHNAALVLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD07</accession>
    <name>A0A7K2ZD07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000615">
        <property type="protein sequence ID" value="MYW30236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="224" mass="25050" checksum="0F7397B67F5C43E1" modified="2021-04-07" version="1">MSVHDVARRLPGISPLHDLCRSLAMLDAILCPEWDRRWHSFDAYWSPTEAMASMRDGAGGEYSLVFSAAGVYVRGFDHESPMSPYVDDGPWPGVLDEVPAVFRDYVDEPSFTDESGLPVATACLWRESTDDRWRAGSIEFPEEGADSDGADWLFQLLTTGTPESYQEWAEDYFEVRLDLEAVRHVYALRPLTDELVAALNPRRAPAELAEDIKEIGYPVGSGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD30</accession>
    <name>A0A7K2ZD30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000639">
        <property type="protein sequence ID" value="MYW30281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512512.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="18516" checksum="4381D4F07ACEBDFD" modified="2021-04-07" version="1">MTMLPRILLPGEGEAVQIGTTTKTTFKAVGHETDDRLGLFEHRMEPGAPGASPHIHREQLEAFYVLDGVVELHLDGETFAAPPGTYVNVPENMSHGFRNPYQDQATMLIIFTPAINREEYFRGLAELYADGNRPTEDELLDLMARYDQFELTLDGTTSRPGWGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD79</accession>
    <name>A0A7K2ZD79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutaredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000652">
        <property type="protein sequence ID" value="MYW30317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10935" checksum="2458EF0EC5579DD4" modified="2021-04-07" version="1">MSPLLRRTKKKPADRVVTLVGKPGCHLCEDARVVVSAVCEETGASWVEKDITEDEELYKEYWEQIPVVLIDDEQHTFWRVDPARLRKALGADVKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDW8</accession>
    <name>A0A7K2ZDW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CchlT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000714">
        <property type="protein sequence ID" value="MYW30544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045937">
        <property type="entry name" value="DUF6357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19884">
        <property type="entry name" value="DUF6357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="421" mass="46177" checksum="BD036A611BFCF69F" modified="2021-04-07" version="1">MSDIVFTRRSGWIPNVIREDGELKLMLGAGADANHDPRTFTFPIGEAHLAVIQEDLARHLLLWSAVLPLCDAAGTRGSLDENAAVALLDPILLSAPADVDALFRRIPWDRGRLIAHGARIDLLERGQVCAALRKATETSDGKRAQEYHANRRRAERGTVLGPLDAAILRYTGQYLHGSTIPKRTPDAVDPALLPEVVRVVATAEQACAGMRIGRDPRRGKRATDKRAWERMAAAVETAVRRAHAGLADDAVRSVSFLMCSEAAGRSRNAPMEDEEEAVGDSADGGGRARKTALSFTDDKGVEKKWRQGGPRSAGAEFWEFVGDRSASDNEVFTIEDEEMGEGVQLHFYADSIARVTTVREGRGGSEPEYRVEYGLVDGMDGYRKMVSTFVLGGCAALDRHGPWMSDVAEFERARRRRRDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE22</accession>
    <name>A0A7K2ZE22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000716">
        <property type="protein sequence ID" value="MYW30576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030572625.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000716.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="13365" checksum="4CEBA8664ABC36F5" modified="2021-04-07" version="1">MTELDVAELQRRLAAFAAARDWGQYHTPKNLASALSVEASELVEIFQWLTPEQSARIMDEPEAAHRVADEVADVLAYLLQFCEVLGIDPLQALAAKLDRNEKRFPVPNPPEPQDRHSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEG0</accession>
    <name>A0A7K2ZEG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000756">
        <property type="protein sequence ID" value="MYW30747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="50"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="34783" checksum="419DC776107CF59C" modified="2021-04-07" version="1">MPFTALATATTPTAHIGLGLAAVGRPGYINLHRDRDFPDGRDVEDLRARTHELLDAAYAQGVRYVDAARSYGRAEEFLGEWLDARPSFTDLVVGSKWGYTYTADWRTEAEAHEVKDHGLATFERQRAETRELLGDRLDLYQIHSLTPDSPALADKELHERLAALAADGVAVGFSTSGPDQADAIRAALALTVDGNPLFRTVQATYNALETSAAPALAEAHEAGLTVIVKEGMANGRLAGDEAPAVFREIAADAGVGGDAVALALVLHQPWAGVVLSGAATVTQLAGNLHAPVVDLDEEQRDRLEALVEEPESYWRHRAALPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEH3</accession>
    <name>A0A7K2ZEH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="43"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="31149" checksum="35741A3AB02FE9CD" modified="2021-04-07" version="1">MDEMRAREVLTAAGFSGAAELLALGENAVFGADGLVVKVGRDATGHPELAARAEREVAVAEWLAASGVPAVRAAEHGMRLVEGHPVTVWHRLPDPVRPTEPHDLAPLLSRVHALPAPADFTLPRRELLGGVERWLTLAGDTIDPDDADYLRGRRDGFAAAAATLTPRLPPGPIHGDALPRNVHVGPEGPVLVDLETFSADLREHDLVVLALSRDRYGLDPAAYDAFTAAYGWDVREWDGCAVLRGARETASCAWVAQHAPANPKALTEFRRRVASLREGDAEVRWYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEH7</accession>
    <name>A0A7K2ZEH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000758">
        <property type="protein sequence ID" value="MYW30767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511825.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000758.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15474" checksum="88A1457957810E28" modified="2021-04-07" version="1">MTTAKDIMHSGARWIPAHETLDRAAQLMREHNVGALPVSANGDSDRMVGIITDRDIVVGCVAKGHDPSKVTAGDLAQGTPRWIDAEADVNAVLEEMQNHRIRRLPVVENKKLVGMISEADLAQHLTEEQIAAWAEKVYSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEJ6</accession>
    <name>A0A7K2ZEJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000761">
        <property type="protein sequence ID" value="MYW30787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="23162" checksum="79CA82547946C624" modified="2021-04-07" version="1">MACDLWLVPLVDVLCHSPDNPFAEEIAVYDRALNDAGLPPVPVFAYMPGLNGDVAPVAGFDYDALHFLRRAYLLQLSGLAVTPVEGLGGDYEQLLEMFEQAAQQSHLVWHYDHAGAYVPVDFPHPLSNDALLEGGGPLGSAHGLLRELEYVAPSIGIDPANPPAAPQPPPGPTALEEPATPVPYDDSPFARERHVWLGLHAAATRSLAQGSMIIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEL4</accession>
    <name>A0A7K2ZEL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">16S rRNA (Adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA</fullName>
            <ecNumber evidence="8">2.1.1.182</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rsmA</name>
        <name evidence="8" type="ORF">GT040_15915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01000743">
        <property type="protein sequence ID" value="MYW30725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="7">
        <location>
            <begin position="40"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="29255" checksum="363947D11D5C1874" modified="2021-04-07" version="1" fragment="single">MSSTEPDALLGPADIRDLAAKLGVRPTKQRGQNFVIDANTVRRIVRTAEVRPDDTVVEVGPGLGSLTLALLEAADRVVAVEIDDVLAAALPATVQARMPERADRFALVHSDAMLVTELPGPAPTALVANLPYNVAVPVLLTMLERFPSIERTLVMVQAEVADRLAARPGNKVYGVPSVKANWYAEVKRAGSIGRTVFWPAPNVDSGLVSLVRRTEPIATTASRAEVFAVVDAAFAQRRKTLRAALSGWAGSAPAAEAALTAAGISPQARGEALTVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEP7</accession>
    <name>A0A7K2ZEP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000760">
        <property type="protein sequence ID" value="MYW30779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="339" mass="37135" checksum="1DA9C9E59E2BCE4D" modified="2021-04-07" version="1">PVPRAAPAPRTKPRRNRRTGKIAQRFVPHDLHPIALRDELIELGNLFRAYQERPEPDLEQLAELHSRKAEAFRTWAEVTGETELRLDAERAEQAAAAALLQHQQRTGQSPVGEGEVTNRLLPGLTQWEHARTVLAHVAEHTPLPGPEARLMAVMLTLRSALTGTGNLVGQDVRGLPLTEPEELIGRLVDSGWLSIPGTAEDLLASRPESPTPITIPSLMPDEDGQGPFDFGRKTRPKLSGWAQRVVGDKKLRKKKTVAATRLLALALAVRTTTDGRLGPEGEGVDLAVLTSWCTVEPDELEPLVEQLTVADWLEEAAVTDGRLTGRLAERVLQVSCPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEU9</accession>
    <name>A0A7K2ZEU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_16760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000775">
        <property type="protein sequence ID" value="MYW30880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="333" mass="37045" checksum="8661F073321B0810" modified="2021-04-07" version="1">MATRAVARRSSTTSGGTDRASSVRAGGGEVADRDLVGMYLDEIARTPLLDAAKEVDLSQSIEAGVYAQQILDGEVESDARGATREELEALVSEGERAKDIFIRSNLRLVVAVARRYPRAGLPLLDLIQEGNAGLVRAVEKFDYAKGFKFSTYATWWIRQAITRSIADQSRTIRLPVHLVEELGRIRRVQREFNRENGRDPEHAEIAAELDSNAERVGNVLDWARDPVSLNMSVDDNGDTQFGDLLEDTSAVSPEQSVMTLLRSEELEDLIGKLDNRTASIIKMRYGIEDGRERTLTEVGKQHGLTRERIRQIEKHALLELKRMAHDTGFDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF32</accession>
    <name>A0A7K2ZF32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Condensation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000809">
        <property type="protein sequence ID" value="MYW30971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="55"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="209" mass="22210" checksum="97F5C5A463C6B710" modified="2021-04-07" version="1" fragment="single">MNTSVGKDTMHLNPPPAPNTPRTVSVTYACGDERRGPLTMGQANMIRCILRDDPEHINNHDVWAVPSGTSVEGAIDALRTLALRHEGLRTTFPHAPGTAPVEQVVAAEGTFTVTVVDHTEFPEEPARYAESVARAARAGRFALDREFPLRISLLTLGGVPVHAALASSHAVTDGSALAVLREEFLALLAGEELPPPASFAPLDLAAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF33</accession>
    <name>A0A7K2ZF33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000805">
        <property type="protein sequence ID" value="MYW30942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029780335" evidence="1">
        <location>
            <begin position="33"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="26424" checksum="3D5E8B30024B1757" modified="2021-04-07" version="1">MTSFAPAVRNHRRTALAVVLCGGLVAALTACAGEDPDKGTNGVGKLSAEQIDTKARAAADSADGVRLAGTLVSKGGTYMLNMKLSDKGGTGSVSSKKRSFVLLRIEEALFIKADADFWRHEEDGKAGRSDQEAAEKLGGKYVKVPEDDPSYRQLRGFTDKKVLLDGLLTLHGTLNKGARDTVTGHRTIQLLGGKGEGGALDVSLEGKPYPVRVARGGGGGTVTLADWGRAVALEAPQDDDTVDYGGKLPKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF50</accession>
    <name>A0A7K2ZF50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_17325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000812">
        <property type="protein sequence ID" value="MYW30991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11574">
        <property type="entry name" value="GH99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CBM6" evidence="7">
        <location>
            <begin position="221"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="673" mass="71307" checksum="9AFA0065040471C8" modified="2021-04-07" version="1">FRHDSIPAGIAAIQQLGTANDFTVTATEDATAFTPQNLATYEAVVFLSTTGDVLNDTQQNALKGYVDGGGGFVGVHAAADTEYDWPEYEDLVGAWFQSHPAIQEARLTTEDHVHPATAHLDDTWTRTDEWYNYRSNPRGDVHILQSLDESSYSGGEMAGDHPITWCHPQQDGRSFYTGLGHTIESFADPDFRQLLLGGIQYAAGAVEADCSSTGDPGPGGDSAEAEAYTSSSGVQSAPHAAASGGATLGYIDDGDWAGYSSLDTAGATAFSATVSSAGAGGTIEIRSGSAAGPLLGSVDVAPTGGWETFTEVTTTLTAGTGPLFLRFTGGAGALFDVDRFTLTRAPATEDEGSSDVHLFYYPWYGTPEGPAGSWRHWQQGGHTPPASIGADLYPKLGPYDSGDIAGAVDQHMEWVQRSGAGVIVYSWWGQGSYEDGLAGDVMDAAARHGIEVAWHIEPYTGRTAASVVDDIADLEGKFGDHPAFYRDAAHGDRNAYYVFESLRIQDWSALDAVKDTAIVLAQTTDTTKVAHFGGIYTYDGIAGATAPGWKQAGDYAKANGLVWAPSVAPGYIDDRAVPGNTTPTLGRADGASYDRQWNNALDPAIGGDPTWVSVTSFNEWHEGSSIEPAASDPPPGHGYETFEGAYGKTGAAAETAYLDRTAYWTDRFEQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFB4</accession>
    <name>A0A7K2ZFB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lant_dehydr_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000824">
        <property type="protein sequence ID" value="MYW31051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="1">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="193" mass="20759" checksum="94538061A52578DA" modified="2021-04-07" version="1" fragment="single">MTNGSPDTWLSLHCFLRSAPEDVDAFLTEGVAPLLDGLGAGDWFFIRYDEGGHHLRLRVRGVSPARAASLPEALARLAERVPVAESVGGQEVGGQDAHGQAEHAEVRVEPYVPETARYGGPAALPVAEEVFILSSRVAVRAVRDTPRGSARLALAIDLAHATALACGMDRLSAAQWLRRHAASWRWAEDVPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFS3</accession>
    <name>A0A7K2ZFS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase (Quinone) flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ORF">GT040_18190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000859">
        <property type="protein sequence ID" value="MYW31149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="47"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="514"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="649" mass="71909" checksum="A6CA74D011568D96" modified="2021-04-07" version="1">MPDYTHYATGEPVVDTKAPEGPVAERWDTRRFQAKLVNPANRRKHTVIVVGTGLAGGSAGATLAEQGYHVVQFCFQDSPRRAHSVAAQGGINAAKNYRNDGDSIHRLFYDTVKGGDFRARESNVHRLAQISVEIIDQCVAQGVPFAREYGGLLDNRSFGGVQVSRTFYARGQTGQQLLLGAYQALSRQIATGGVELHARTEMLDLIVVDGKARGIVARDLVTGKIDTYFADAVVLATGGYGNVFYLSTNAMNSNATAIWRAHRRGAYMANPCFTQIHPTCIPRTGDHQSKLTLMSESLRNDGRIWVPKAKGDDRPADQIPEDERDYYLERIYPAFGNLVPRDIASRAAKNVCDEGRGVGPGGQGVYLDFAEAIGRMGRKAVEAKYGNLFDMYQRITDEDPYTVPMRIYPAVHYTMGGLWVDYDLSTTIPGLFAIGEANFSDHGANRLGASALMQGLADGYFVLPSTINDYLARNPHTEKVDDEHPAVAEVVAETEDRINLLLSVDGDRTPDSFHREIGELMWEHCGMARTEDGLRKALAKIPEIREEFWRRIKVPGTGEQFNQSLEKANRIVDYLELAELMCLDALHRAESCGGHFRAESQTPEGEAERRDEEFSYAAAWEFTTTGGAPVLHKEDLVFEYVHPTQRSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG56</accession>
    <name>A0A7K2ZG56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000905">
        <property type="protein sequence ID" value="MYW31351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6265" checksum="0B7B2C19BF10BDEA" modified="2021-04-07" version="1" fragment="single">MDSRSHTHVTAALRLCLHALLLGLLALVAVRAVGEGAPHAGAVVALTLVTAGVYGAGALAGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG77</accession>
    <name>A0A7K2ZG77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000903">
        <property type="protein sequence ID" value="MYW31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13114" checksum="D5732705C5F0623C" modified="2021-04-07" version="1" fragment="single">DLASAYTARAAGIAPEFTPLTGQYVDHAARLQQLLGTPADPTPLAEAQLAHWREALAGLPDQLELPTDRPRPPVATSAGDTVPFALDTATHEALRRLARAHGATVFMTVQAGLAALLTRHGCGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGP5</accession>
    <name>A0A7K2ZGP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000930">
        <property type="protein sequence ID" value="MYW31488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="425" mass="45010" checksum="9B88581C7E930F3D" modified="2021-04-07" version="1">MGEAVQRRFTVLTAVVAALGMTATLSGCGGDSGSGDVTLTLVAADYGNSAANSSEKYWSGVAAGFEKEHPGIKVEVNVYSWKDVDRKVAEMVKAGKAPDIAQIGAYADYAKDGKLYSADQMLSIRTQANFLPTLTDAGKVDGTLYGLPFVASTRLLFYNEKLFGQAGLDAPETWDDIQKDATALKAKGVKYPFALPLGQEESQAETLMWLLSNSGGYVDDVGLYDIDSAQNIATFSWLRDNLVGKGLTGPVAPGELDRAKAFEAFTKGEVGMLNGHPTLMEEAEAKGVKVGMVPLPGAEGPTKGSMGVADWMMGFKQNGNRKAIGEFFDYAYSDENVLAFADEYDLLPVTGSASAEMETDSKHAKLREFLAALPNSQLPPFGKTSWATVSESIKMNIGEAVAPGGSPERVLGSIAAEAAKAESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH09</accession>
    <name>A0A7K2ZH09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">purU</name>
        <name evidence="5" type="ORF">GT040_05255</name>
        <name evidence="6" type="ORF">GT040_20330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000245">
        <property type="protein sequence ID" value="MYW28689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01000964">
        <property type="protein sequence ID" value="MYW31559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="33410" checksum="F88B09B2F33F15DB" modified="2021-04-07" version="1">MTAPQPTASQADSDTALPEQYVLTLSCPDKQGIVHAVSSYLFMTGCNIEDSQQFGDHDTGLFFMRVHFSADATVTVDKLRASFAAIGEAFRMEWQIHRPAERMRIVLMVSKFGHCLNDLLFRSRTGALPVEIAAVVSNHTEFAELTASYGIPFRHLPVTKDNKPEAEARLLELVREEDVELVVLARYMQVLSDDLCKQLSGRIINIHHSFLPSFKGAKPYHQAHARGVKLIGATAHYVTADLDEGPIIEQEVERVGHDVTPDQLVAIGRDVECQALARAVKWHAERRILLNGRRTVIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHC4</accession>
    <name>A0A7K2ZHC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="38" mass="3165" checksum="BE8E8A5190441498" modified="2021-04-07" version="1">GGPQGGGQQGGGGGWGGSPGGSGGSGGSGGGYSDEPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHF1</accession>
    <name>A0A7K2ZHF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001014">
        <property type="protein sequence ID" value="MYW31745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="57" mass="6215" checksum="27A2F592ADC967F9" modified="2021-04-07" version="1" fragment="single">MKLSLPDFLTPSSSYEPPATVRTRREGPVLHVELYAPETGNAVTEAMLDELLEAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHI8</accession>
    <name>A0A7K2ZHI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001021">
        <property type="protein sequence ID" value="MYW31821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="26583" checksum="9B541DF8D7A9B5F4" modified="2021-04-07" version="1">MSAQSYVSDLFSLAGRVAVVTGGSSGIGRAITGALARAGARVVVVARRESELKTTVDELEAAGCRAGWVSADLATAEGVRAAADGAVAAFGEPDILVNCAGINLRPPMDELGEDVWDTTMAVNLKAPFLLGQRFGPGMAERGYGRIIHVSSQQAHRAFVNSGAYGVSKGGLESLARSQAEAWSPYGVTVNTLVPGFVLTPLNQRLAADPEKVASLAARTLVGRNGLAEDFAGAAVFLAGPSSAYVTGQALHVDGGFSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHJ1</accession>
    <name>A0A7K2ZHJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001016">
        <property type="protein sequence ID" value="MYW31785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7500" checksum="E465D4A4BB815E89" modified="2021-04-07" version="1">LRSLDELTARRPAETGHDLTASAVAGIFTGVLADWVHGQVTAQPEQLAGRIWRMLLAVHAAARLTQRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHL3</accession>
    <name>A0A7K2ZHL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CocE/NonD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001021">
        <property type="protein sequence ID" value="MYW31827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="275"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="492" mass="52407" checksum="2E098448516B3D2E" modified="2021-04-07" version="1">ASGASAPGLTFHDIPGSGGITLKGNVFRPSGASAGAKHPLIVFPTSWAMPQIEYLAQAQKLADSGYVVVSYTSRGFWLSGGKIEVAGPPDIGDASAVIDWALANTSADPDRIGMGGVSYGAGISLLAAGHDPRIKAVAALSGWADLIDSIYSGRTQHLQAAALLGGAGLITGRPSDELSQTLKDFLGSNLAKEPEMIAWGAKRSPATHLDKINANGAAIMMGNAWGDTIFPPNQYASFYEKLNGPKRLEFRPGDHATAELTGLFGLPNDTWTSTRRWFDRYLKGERNGIDTEQPVQLKSRTDKGYEGYADWKSVGAAKNRVQLDGTKKVWANVDSGANGGITLLSNALDQFLKLPPTVSVPLLPRTFASVWQSERYGSEQRVRGTAELHTTVTSTKSSGTFVAYLYDVGPLGVGKLVSNAPYTFHGQTPGRPFPVDLELFSTAYDVPAGHRLALVIDTVDPLYIEHNPTGAQLTFSSPASDPSHLSVPLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHU7</accession>
    <name>A0A7K2ZHU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_22310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="391" mass="40620" checksum="E31B6FDE11A6CDA6" modified="2021-04-07" version="1">MTRSPGTARLVRRALHAPEAGRSNALPAGAWWLWALGLATAASRTTNPLLLGLLVGVAGYVVAARRTDAPWARSYGAFIKLGLFVVALRLVFSVFLGSQIPGSHTVFTLPEVPMPDWAQGVRIGGRVTAEQLVFSLYDGMKLATLLICVGAANSLANPARLLKSLPGALYEVGVAVVVAMTFAPNMVADVVRLRTARRLRGRPTGGVKAVAQIGLPVLEGALERSVAVAASMDARGYGRTAQVPPAVRHTTNVLTLGGLLGVCAGTYGLLAAQGAVYGLPVLLAGLVAAMAGLRLGGRRSVRTRYRPDRWGVRAWLVAGSGAVVAAAMIWAGSVDPEALHPGVVPLTAPVLPLWPAAAVLVGLVPALAAPVPPSSRGRDFEEHGPRGKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHU9</accession>
    <name>A0A7K2ZHU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001060">
        <property type="protein sequence ID" value="MYW31924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029465525" evidence="1">
        <location>
            <begin position="28"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="18914" checksum="6592A7D29BA9734B" modified="2021-04-07" version="1">MRRVISIALSTAVLSGGFVALASPASAACDDTGTKFAIINKKTVWKNTNLHSDWGKPGVTLRYDKTKSATLSASGTAEVGADAGVIFAKASTSFGVTVGKSWTKGDTWSYSATVKKKKGKTRGRLMMQHEAKQFTAHKYKVFTGAGGVCKTKTVYKKKLTAPVKKDRQNLWGIQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI74</accession>
    <name>A0A7K2ZI74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">raiA</name>
        <name evidence="2" type="synonym">hpf</name>
        <name evidence="4" type="ORF">GT040_22875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001071">
        <property type="protein sequence ID" value="MYW32037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="25010" checksum="00456B8D5D04742A" modified="2021-04-07" version="1">MDIVVKGRKTEVPERFRKHVAEKLKLDKIQKFDGKVISVDVEVSKEPNPRQADRSDRVEITLHSRGPVIRAEAAAGDPYAALDLATGKLEARLRKQHDKRYSRRGNGRLSAAEVGDVVPGVASFDEDGELVGEQPSEPVPTTKVGSIEVQGEGPLVMREKTHTAAPMALDQALYEMELVGHDFYLFVDSETKEPSVVYRRHAYDYGVIHLRTDPLAADEAGGAGGALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIC8</accession>
    <name>A0A7K2ZIC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_23205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001088">
        <property type="protein sequence ID" value="MYW32101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="58"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="163"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="34148" checksum="EF881B59E5A7D499" modified="2021-04-07" version="1">PPTDAAIVAEELVRAGVPDTLHVNTIQIVGQFLLMAGTTAQKQRHLPRLARGERFASVLYTEPDAGSDLGALRTVAEPDGDGYRITGTKVFSLKTRFVDYGLCAARTTPDAGKYQGISLFLVGLDAPGVTVSLIPGISDEQFHQVDLDSVPVSGDDLLGARDQGWPLLNEALAIERTGLDYYLKAEHWLEAALRALVDREPRDPHDALPDLERIGRWEGTLMADHALAWEVLTQLASDRVDPVTAAVAKYHSSELAQAIAMWAAGIPDPGQRAARTGAAVTLDSAHREAPGLTLSAGTSEVMLQIITTAFDSIGQENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIU6</accession>
    <name>A0A7K2ZIU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001126">
        <property type="protein sequence ID" value="MYW32276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="31934" checksum="76E728EE5630F7A3" modified="2021-04-07" version="1">MRAEAGARYDQQGRNGQGGRFAWLGELSLVLLLVVVGILVISGIGAVLAAVLDAGPSSAESEVFFEDPVADMALQLVGIAIGIPIVLWGARYLGRRPAGTVSSVLGRLRWKWLGLCAAVAFPVIIVQFGVLFAWTWGDESAELTGGGFPGWTAFLVSLAVLVALVPFQAAAEEYVFRGWLVQVIGRAVRSPWPAVVLASLLFALAHGFGELTGFVLLLYSALWWGWLVIRTGGLEAVITLHVANNLLAFGLAAGFGELASTETAADAPWQAMVVEFVFAPLYCLGVAWLAKRRGVERVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIY9</accession>
    <name>A0A7K2ZIY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001136">
        <property type="protein sequence ID" value="MYW32304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12731" checksum="F654F8C2CCE5AF8B" modified="2021-04-07" version="1">EALSSARHMIRAAVRAWGAKERADEIELAADELTTNALMHTDGGAVVTIRVMAGSERRLRVDVEDRSSALPRRRDAGSDGVSGRGLMLVDRLADVWGVEARGSGKCVWCEFLIPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJN3</accession>
    <name>A0A7K2ZJN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029844014" evidence="2">
        <location>
            <begin position="30"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="66"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="311" mass="32224" checksum="490DE8C04CCA7068" modified="2021-04-07" version="1">MTQPLRRLTRAAAVAVAGTLLLSGCGSDKIDGVPGPGSVTGESRAAVSADPELVAMVPPAIASKGTVTIAVDATYAPGEFKDASGRIVGFDIDLGDAVFTRLGLKTQWQAADFGSILGGLTAKKYDLSISAFTITRERVKTLDMVQYFVAGEAIAVLAGNPDKVPDSPDGLCGLTVAVQTNTVAADKIRNTINPACTKAGKPQIPNDGDQFPAQTDAINAVIAKRDQVLLADSPVIDYAIRQNGRLEKLGENHNIAPYGIALPKGTGLTRAVQAAVKALIEDGTYGRILDKWGVSSGAVSAAQVLVNKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJU6</accession>
    <name>A0A7K2ZJU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BtrH_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026935">
        <property type="entry name" value="BtrH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14399">
        <property type="entry name" value="BtrH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BtrH_N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="350" mass="37552" checksum="379D5985D8FE4DF9" modified="2021-04-07" version="1">MTSDVTPRTYMITGPEPELWYRDLISCLQATFGTLVARAGADPLAVLGSGWSFLHLPGDVRSEEFYYPCPPGESDGADLGAALAPHHDLHARWWQPADQDDLWREMREALADDRPVIAAVDNFHLPFRPAYGDVHAAHLVVVYGLDEVRGLVYVSDAMPPAFRGAVPIEAFLRSWGSANPTDVQDAFFSDSRIDRRCLDVRLGASPPPLTPELLGGFLRADVDGFTTATAARTGLAGFDEFAAELADRTRAGDADALRDLYAFGWGMQAQASLHGELLRRCGREWDEPALAGAGRAVEAVAHAWTGLRITGAHGLGDPRAASSDIAHHSTVLRGAYAGAVDAVGAAAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJV1</accession>
    <name>A0A7K2ZJV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_25980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001207">
        <property type="protein sequence ID" value="MYW32628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029492783" evidence="7">
        <location>
            <begin position="26"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="546" mass="55222" checksum="75BE9DB1172FF2F2" modified="2021-04-07" version="1">MILIAVSVALMAVIASVSGLNVAQTDLAVEFGASQSTVLWIINIYTLALAALLLPLGAIGDRIGRKPMLIAGLIVFGVASVLAGLAPTAGIMLAARVLSGVGAAMIMPITLAVITSTFPEEERGKAIGVWTGVAGGGGVIGMFLSALLVDVASWRWLFLLPVALVGVALAMTLRSVPDSREHAGHSFDTVGALASVVAVTGLIFALQEGPEKGWGAPVTLSALAVGILAATAFVARELRRREAALLDVRLFRERRLASGSLTLLVVFGVQAGIAVVLFPFLQAVLGWSGLLSTLALMPMAVLMMLTSGLAPRLAARVGARTTMATGIALGGAGLALMALFVSVGGGYLSILPGMLAMGLGMGLAMTPSTEAITASLPRERQGVASALNDVTREFGTALGVALLGALLSAGYRSAVDDRLGGIPRDAADTAREGVANAVEAAGGAGPHREALLDAAQRSFVDGWQQAMWAGVAVMAALLLLVLLRGPKSPAPGAGADAPAPRTGAPSLQEAVRAGRTAPPTGRPVPPGRAADLPGSAPGSSPSRPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK21</accession>
    <name>A0A7K2ZK21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001231">
        <property type="protein sequence ID" value="MYW32702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="212" mass="21583" checksum="91C81E2F6652B09C" modified="2021-04-07" version="1" fragment="single">MSTTEQRVAIVTGAARGIGAATAVRLAAEGRAVAVLDLDEAACKDTVEKITAAGGTALAVGCDVSDSAQVEAAVARVAAELGAPTILVNNAGVLRDNLLFKMSESDWDIVMNVHLKGAFLMAKAVQAHMVEAKFGRIVSLSSSSALGNRGQANYSAVKAGLQGLTKTLAKELGKFGVTANAVAPGFIVTEMTAQTAARVGMGFEEFQAAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKA2</accession>
    <name>A0A7K2ZKA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_26805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001251">
        <property type="protein sequence ID" value="MYW32784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="807"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="842" mass="93109" checksum="7E3FB61D07C6ACBC" modified="2021-04-07" version="1">MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEAVRQQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYSGGKETAAAGGPAEGTPSTSLVLDQFGRNLTQAARESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVKGEVPETLKDKHLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDELHTLVGAGAAEGAIDAASILKPMLARGELQTIGATTLDEYRKHLEKDAALERRFQPIQVAEPSLPHTIEILKGLRDRYEAHHRVSITDEALVQAATLADRYISDRFLPDKAIDLIDEAGSRMRIRRMTAPPDLREFDEKIAGVRRDKESAIDSQDFEKAASLRDKEKQLLAAKAKREKEWKAGDMDVVAEVDGELIAEVLATATGIPVFKLTEEESSRLLRMEDELHKRVIGQKDAIKALSQAIRRTRAGLKDPKRPGGSFIFAGPSGVGKTELSKTLAEFLFGDEDALISLDMSEFSEKHTVSRLFGSPPGYVGYEEGGQLTEKVRRKPFSVVLFDEVEKAHPDIFNSLLQILEDGRLTDSQGRVVDFKNTVIIMTTNLGTRDISKGFNLGFAAQGDVKTNYERMKVKVNEELKQHFRPEFLNRVDDTVVFHQLTEEDIIQIVDLMLAKVDERLKDRDMGIELSSEAKSLLAKKGYDPVMGARPLRRTIQREIEDILSEKILFGELRPGHIVVVGVEGEGDDKKFSFRGEEKSALPDVPPIEQAAGGAGPNLTKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKF4</accession>
    <name>A0A7K2ZKF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_26960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001255">
        <property type="protein sequence ID" value="MYW32815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015609839.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001255.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="127"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="249"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW32815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="376" mass="39629" checksum="4346A3B8B7068097" modified="2021-04-07" version="1">MKIRVERDVLAEAVAWVARSLPARPPAPVLAGLLLKAEDGALSFSSFDYEVSAKVSVDAEVDEDGTVLVSGRLLADICRALPNRPVEISTDGVRATVVCGSSRFTLHTLPVEEYPALPQMPTATGTVPGEVFASAAAQVAIAAGRDDTLPVLTGVRIEIEGDTVTLASTDRYRFAVREFLWKPEDPEASAVALVPAKTLLDTAKALTSGDTVTLALSGSGAGEGLIGFEGAGRTTTTRLLEGDLPKYRTLFPTEFNSVAVIETAPFVEAVKRVALVAERNTPVRLSFEQGVLILEAGSSDDAQAVERVDAVLEGDDISIAFNPTFLLDGLSAIDSPVAQLSFTTSTKPALLSGRPAVDAEADDAYKYLIMPVRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLI7</accession>
    <name>A0A7K2ZLI7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Adenosine deaminase</fullName>
            <ecNumber evidence="1 3">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 3">Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">add</name>
        <name evidence="5" type="ORF">GT040_29160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:28190"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="1 3"/>
    <dbReference type="EMBL" id="WWKE01001355">
        <property type="protein sequence ID" value="MYW33227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00540">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028893">
        <property type="entry name" value="A_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="384" mass="42321" checksum="0A7E0BC8E2D8A408" modified="2021-04-07" version="1">MTSQTPNVPDSDQIRRAPKVLLHDHLDGGLRPGTIVELARAQGYDSLPETEADKLGVWFREAADSGSLPRYLETFAHTCAVMQTRDALFRVAAECAEDLAEDGVVYAEIRYAPEQHLEGGLTLEEVVEAVNAGFREGERIARANGHRIRVGALLTAMRHAARALEIAELANSYRDQGVVGFDIAGAEAGFPPTRHLDAFEYLKRENNHFTIHAGEAFGLPSIWQALQWCGADRLGHGVRIIDDIEVAEDGSVALGRLASYVRDKRIPLEMCPTSNLQTGAATSYAEHPIGLLRKLHFRVTVNTDNRLMSGTSMSREFELLTEAFGYTLDDMQWFTVNAMKSAFIPFDERLAMINEVVKPGYAELKSEWLFRQTAVTSGSAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM43</accession>
    <name>A0A7K2ZM43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="46" mass="4689" checksum="F0544A179F95EE42" modified="2021-04-07" version="1" fragment="single">MRLTVFGATGGVGQEVVGQALAAGHEVTVVVRAPARLPEAFDARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMC0</accession>
    <name>A0A7K2ZMC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001396">
        <property type="protein sequence ID" value="MYW33450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15841" checksum="E0BA9653138883BD" modified="2021-04-07" version="1">MDLTVVAYVLYLLISVALTVWVARTLSRNGRVFLADVLHGNEKLAEAVNHLLVVGFYLVNLGFVTLYLKNADGVANARELFEALSVKLGVVLLVLGVMHLGNVYALSRIRRRSALEREQTPPVAPQGWTKPGPTGPWAAPAPTPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMF0</accession>
    <name>A0A7K2ZMF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001429">
        <property type="protein sequence ID" value="MYW33543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="7532" checksum="7527CF8564613F8B" modified="2021-04-07" version="1" fragment="single">MRATVAYVKQRTQFGVPVGSFQAVKHRLADTLLGLEFARPLLYGAAVELAEGSPGAGAAVAAAKVAAGEAGYAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMQ7</accession>
    <name>A0A7K2ZMQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001437">
        <property type="protein sequence ID" value="MYW33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029636027" evidence="1">
        <location>
            <begin position="30"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="83"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="532" mass="57430" checksum="5EA3213805D60678" modified="2021-04-07" version="1">MNRKTLVLPAVVGLLAPVLAACGSTDSGAGGGNAIVVGTTDQLVASEENPAPLDPAIGYEAGVWNVLRQTVQTLTTVPNGGGEPVPEAAQSCTFTDNANESYRCTLRAGLKFADGTPVTAEDVKFSIQRVIDINSDSGPVGLLANIDTIETKGSDQVIFHLNTPDATFPYKLATPAAGIVPKGKYPAKEARDGFQVDGSGPYTMKPQVEDGRVTRIAFTKNPSYKGELKVLNDKVEMDLFPDADAMGEALEEKKIHMMTRAMSPEQARDMLVKPKEGIELTEMPGLAISYLGFNTKDPVVNKSVRQAMAQIIDRGEIAGKVYGTTAEPLYSLIPSSITGHTNAFFNKYGEPSAAKAAQTLKNAGVKTPVKFTLHYTNDHYGSATAKEFKALQAQLNGSGLFDVDVQGKEWSKYRPEQKRGDYAAYGMGWFPDFPDPDNYTAPFLDKNNFLNSPYRSQEAQNVLIPKSRRVADRSAAATTYEKLQDIVATDVPLLPIWQGKQYVASRSGVAGVERSVSATSELQLWELNKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN18</accession>
    <name>A0A7K2ZN18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001447">
        <property type="protein sequence ID" value="MYW33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="27081" checksum="7262F0E3DD649FA7" modified="2021-04-07" version="1">MAKLNQIIAVEKGVKSKAHQDLTAAHHGLQKAGLLAGISRTYQPKDEEGEQLPPESTLVQVKAEDVLRDTASTLTRLFDVTATKDWANCSARADVKVDGRVLVAEVPVSYLLFLEKQLTDLNTFIRKLPVLDAAESWVQDPSTDSWKTEPVRTLRTKKVPRNHVKAEATEKHPAQVEVYYEDIPIGYWTTVKFSGALPARRVNELLDRVEKLQQAVKFAREEANGADVTDQRVGDAVFGYLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN51</accession>
    <name>A0A7K2ZN51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_31590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="339" mass="39160" checksum="6F877D5D52D2CA3E" modified="2021-04-07" version="1">MSTTNNEKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLHSDVADLAKLSPGEQHMIGRLVAFFATGDSIVSNNLVLTLYKHINSPEARLYLSRQLFEEAVHVQFYLTLLDTYLPDPDDRAAAFDAVEEIPSIREKAQFCFKWMDSVEKIDRLETKADRRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMNFAFEVVDTVRKEEPELFDDALQQQVTDMLKEAVEAELQFGRDLCGEGLPGMNTESMRQYLECVADQRLARLGFPTVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGSVGFDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN73</accession>
    <name>A0A7K2ZN73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001482">
        <property type="protein sequence ID" value="MYW33806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="234" mass="24505" checksum="CD4F84B9E3A656FD" modified="2021-04-07" version="1">MTNFVLVAGAWPGSWAWSDVLPGLRAAGHTAHPLTLSGLADRRGAQAGQQTHVDDIVSHVERLDLRDVVLVGHSYAGIPAGQAAERIGDRPARVVFVDSSVPADGESFVSGWPEGRAQVEAAIAANDGFRPVLTADDCAGQELGDEETARIVGGATPHPGATLTEPAVLRGSLGELPATYVKCLFDGPEPGPEVAALLKGERWGLVTMETGHWPLFSRPDELARVLLDAAGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNC0</accession>
    <name>A0A7K2ZNC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="188" mass="21407" checksum="B5A585D76BAAECB6" modified="2021-04-07" version="1">MSDLWTGERVRLRGIEPADWEGFRALALHTVDARNADVVDPPRSDESFRTWAAERADRTPDPAAYQLVIETRFEHAFVGAVSVGETDARAGRFRTGIEVTREHRRQGYAAEATELVLTYMFAEQRSHKCEVEVYAFNDASLALYRKLGFVEEGRLRQHEFFAGAYHDVVLLGITADEYWAGRARPSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNR6</accession>
    <name>A0A7K2ZNR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GT040_33260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001522">
        <property type="protein sequence ID" value="MYW34011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="Complex1_51K" evidence="13">
        <location>
            <begin position="56"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="14">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="NADH_4Fe-4S" evidence="15">
        <location>
            <begin position="330"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW34011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="500" mass="51758" checksum="83DE8E10A93C5B25" modified="2021-04-07" version="1" fragment="single">MNAPLPDVPEVRVVGLPQLTTGFDLVERLDLAMHLKVHGPLEPMTGERLAELAEAISLRGRGGAGFPFGKKMRAVAKASIRRGVRPVVVINGSEGEPACRKDTVLLNRAPHLILDGALLAAEALGARTLVVAVTRNSTEVSVRAALAERGLSDRRGQQLRARVVRTPERMVSGEASSVIRAANGGPAMPPGRRERAAETGVGGSPTLLSNAETYAQLAVAARIGPRRYGHTGLPDEPGTVLLTVSGAVARPMVIEVPTGVPLRYILQLAGAPPLPQGVLTGGYHGNWIDAVASHNAVISRESLATVGGALGAGAILPIGPETCPIGESLRIVNWLAAETAGQCGPCKLGLPAAAGGLSDVLNGGGPAALEALREVTQAVKGRGACKHPDGSARFLMSTLSAFTDDLAAHVLDGGCGRETLGVLPLPASGYQDLEESIPSGEKLAVDWTLCQGHGLCADIVPELIRLGPDGYPAVADASVPMHLRGRAQRAVRRCPALALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNT2</accession>
    <name>A0A7K2ZNT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Primosome assembly protein PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001525">
        <property type="protein sequence ID" value="MYW34016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="20858" checksum="1550E398833F974C" modified="2021-04-07" version="1" fragment="single">LEAPDQQDLNCAWCGRAERAWHCAECGSNRLRAQIVGARRTAEELGRAFPAVPVRTSGRDHILDAVPAAPALVVSTPGAEPVAEGGYAAALLLDGWAMLGRPDLRAGEEALRRWTAAGALVRGQDEGGTVVIVAEPTLRPVQALVRWDPAGFARRELADRAELRFPPVSRMASVTGPAEALASFLAAADLPPEAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP52</accession>
    <name>A0A7K2ZP52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001550">
        <property type="protein sequence ID" value="MYW34154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="32"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="21913" checksum="D7E5EDDC68D7FF11" modified="2021-04-07" version="1">MALFTRKSTAATPTTVAEAPAVDPALAALTGVYTIDPAHSSIGFTVRHAMVTNVRGSFGEHEGTLTLDGTDPANSSAAIDVKIASVDTGIADRDGHLVSGDFFDAEKFPLMTFRSTRAEQLGGEAYRVTGDLTIKDVTRPLSIDLEFNGSATDVYGNERVGFEGSTDILRSDWGLTWNAALETGGVMVSDKVKLNFDISAIKAAAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPA4</accession>
    <name>A0A7K2ZPA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Condensation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001555">
        <property type="protein sequence ID" value="MYW34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="36475" checksum="D2C37A98FCB842E6" modified="2021-04-07" version="1">QLTLRSGRGARALASAAGRIGNPEATVLLAAWCALVAHRSGQDSCVTAVPTSNRFHPTIARSVNTLSQDALLCLDVRVPSFDTLVRKTWGAALNAYRHSQFDSVRLWEMIDRVTGERGSHFARDVVFNDVSVLPATLLSISPQESRAAELDLTWGPFQALPTRMLAFTYETAPQLHLSLWADPALFTPGEAEGFLTGLVRLLEAAAIRDVPLESLTGVTGVGQAVRGRDWTRVDGCWVSPSAVQDALGAAVGGLPVHIATDAGGSGLTAYIARGGDTAPTPTGVHEALMAALPAHGGSGVIAPARYVLVESPPAERDRSDAWRRLQIIEEGTGRSRQVRHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPM5</accession>
    <name>A0A7K2ZPM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001590">
        <property type="protein sequence ID" value="MYW34302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6880" checksum="F8CFDF7E56332909" modified="2021-04-07" version="1">MVSMEESGRTMVEEPTWAELLVMFLFVGAIPVVIGGAAILSLVGLTLWARALLRRRKHPSTGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPY7</accession>
    <name>A0A7K2ZPY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_35010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001598">
        <property type="protein sequence ID" value="MYW34348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="3">
        <location>
            <begin position="101"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="26587" checksum="858570EA7F46D57B" modified="2021-04-07" version="1">MSARRRPPARRAASRPRERQKRQGSGKRPQRHPAAVLIPLVIALWVVGRLLDWVAANRWVVVVALALAVAGGLLWHRHRAAQLRAEHERARALRYRVEQLDHLHHRAFEHAVRDLMFRDGCTDAVQVGGAGDHGADVKATDPYGRRWVIQCKHRKAGAAGAPVGTPDLHVLNGTGRPVHHGDVIVLVTNGRFSRPAVEFARSQRLHLVDRTSLAAWAAGGRPLWELLRAVPPPRSPSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQM0</accession>
    <name>A0A7K2ZQM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber evidence="12">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nuoF</name>
        <name evidence="14" type="ORF">GT040_36640</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="WWKE01001675">
        <property type="protein sequence ID" value="MYW34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="13">
        <location>
            <begin position="341"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="459" mass="49887" checksum="421D19BC0EDD7593" modified="2021-04-07" version="1">MTLAAEIDHNGTSPEKLLAPVLSSFWDQPESWTLETYRRHEGYEGLRKALAMSPDDLIAYVKDSGLRGRGGAGFPTGMKWQFIPQGDGKPHYLVVNADESEPGTCKDIPLLFANPHSLIEGIVIACYAIRSSHAFIYLRGEVVPVLRRLHEAVREAYEAGYLGTNVLGSGLDLELTVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPAILNRGKDWFKSMGSEKSPGFTLYSLSGHVTSPGQYEAPLGITLRQLLDMSGGMRAGHRLKFWTPGGSSTPMFTDEHLDVPLDYEGVGAAGSMLGTKALQCFDETTCVVRAVTRWTEFYAHESCGKCTPCREGTYWLVQLLRDIEAGKGEMADLDKLNDIADNINGKSFCALGDGAASPIFSSLKYFREEYEQHITGKGCPFDPAKSTAWADDKNTDGKNAHRGVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQV8</accession>
    <name>A0A7K2ZQV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-alpha-glucanotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001663">
        <property type="protein sequence ID" value="MYW34639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8115" checksum="1D360267D8ACD0FB" modified="2021-04-07" version="1" fragment="single">MGLSRLAALHGVATSYSPSPDVTVSVPDDTVIAVLAAVGVDAGTPEDVRRSLVAAESRSRLLPPTVVVWAGEPLPPALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR49</accession>
    <name>A0A7K2ZR49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SapB/AmfS family lantipeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001701">
        <property type="protein sequence ID" value="MYW34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015611153.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001701.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045825">
        <property type="entry name" value="RamS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19402">
        <property type="entry name" value="RamS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="43" mass="4534" checksum="85FD05FE2A1BD3D1" modified="2021-04-07" version="1">MALLDLQAMETPAEESFGELATGSQVSLLVCEYSSLSVVLCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR83</accession>
    <name>A0A7K2ZR83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001723">
        <property type="protein sequence ID" value="MYW34900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="21549" checksum="277A4C5CBB5F1408" modified="2021-04-07" version="1" fragment="single">MSSFPSSAPRVEEWRHLRITRDDGVVTVTLDRPEKLNALTFGAYADLRDLLAELTRERSARALVLAGEGRGFCSGGDVDEIIGATLAMDTAAVLEFNRMTGQVVRALRECPFPVVAAVHGVAAGAGAVLALAADFRVADPSARFAFLFTRVGLSGGDMGAAYLLPRVVGLGHATRLLMLGDAVRAPEAERIGLISELADEGQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRE7</accession>
    <name>A0A7K2ZRE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">hutU</name>
        <name evidence="13" type="ORF">GT040_38030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="WWKE01001726">
        <property type="protein sequence ID" value="MYW34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="136"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="346"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="552" mass="59643" checksum="C78C12E1D2306DA3" modified="2021-04-07" version="1">MSGPRPVRAPRGNALSTLGWQQEAALRMLQNNLDPEVAEHPDKLVVYGGTGKAARDWRSFDAMVRTLQTLKQDETMLVQSGRPVGVMQTHEWAPRVLIANSNLVGDWANWEEFRRLEALGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVAAKKFGGTLAGTITLTAGLGGMGGAQPLAVTMNDGVAICIDVDPRAIERRIEHRFLDVKADNLEHALQLAVEARDARRPLSIGLLGNAAELLPRMLAEGAPIDIVTDQTSAHDPLAYLPIGVDFDDMATLAAEKPADFTQRARESMARHVEAMVGFMDAGAEVFDYGNSIRGEAQLAGYDRAFDFPGFVPAYIRPLFCEGKGPFRWAALSGEAADIHKTDQAMLELFPENESLHRWIKMAGERVHFQGLPARICWLGYGERDKAGERFNDMVASGELAAPLAIGRDHLDCGSVASPYRETEAMLDGSDAIADWPLLNAMVNVASGASWVSLHHGGGVGMGRSIHAGQVTVADGTKLAGEKIRRVLTNDPGMGVIRHVDAGYDIAESVAEDKGVRVPMAEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRP7</accession>
    <name>A0A7K2ZRP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001768">
        <property type="protein sequence ID" value="MYW35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="23762" checksum="7FA23D76659A2A17" modified="2021-04-07" version="1" fragment="single">PEGRAARTALALREATAAGGWALLDHPMLALEVAGSPAYLEPDAVVVHPDGRWTVVEIKSFPMIDASADAAKVGAAARQAAVYVLALERVAAVTEGAEVGHQVLLVCPKDFSNLPTASVVDVRKQRAVTRRQLTRLTRIEDIAEALPEGTTFDPACSPQELESAVSSVTAAYAPECLAACELAFHCRARSRAEGAVETLGRSVRGELGGLTTVAGVLAAAAGKEGDPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRS1</accession>
    <name>A0A7K2ZRS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3040 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001765">
        <property type="protein sequence ID" value="MYW35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="15145" checksum="096070FB0167AA01" modified="2021-04-07" version="1">MPLSEHEQRMLEQMERALYAEDPKFATALEGSGLRTYTRKRVYQAVAGFLVGIALLMAGMVAQQIWISVVGFLVMLGCAVLAVTGWRKAPKPGEQQQAATDGGDGGSRRRPRQRRSVMNRIEQRWQRRRDEQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRT0</accession>
    <name>A0A7K2ZRT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-6y C5,15-methyltransferase (Decarboxylating) subunit CbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbiE</name>
        <name evidence="8" type="ORF">GT040_38405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001739">
        <property type="protein sequence ID" value="MYW34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="385" mass="40620" checksum="D8B78C82C49FC6E9" modified="2021-04-07" version="1">AGVRVAWPSPLRPAVPRLLAEHRERRIAVLASGDPMFYGIGRALAEELGPEALRVFPHPSSVSYACARLGWPLEDTEVVTLVGRPVSRLAVSLHEGRRLLVLSADASTPATVAALLTAHGFGPSRMRVLEQLGSEAEAYVEGVADSWAHAPGDRLNVIAIDCRASADALRLGAVPGLPDEAYEHDGQLTKRHIRAATLGALAPAPGELLWDVGGGSGSIAIEWMRTHPTCRAVSVERDPARAERIARNADRLGVPGLRVVTGPAPSSLSELSELSELSELEVPDAVFIGGGLTAPGLLDACWEALRPGGRLVANTVTLESEALLAERYRAYGGELTRLAVAHAVAVGGFTGWRQAMPVTQWSVRKPSFAAPVPAPAPVSVPGDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS43</accession>
    <name>A0A7K2ZS43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc ABC transporter solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001781">
        <property type="protein sequence ID" value="MYW35152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029454424" evidence="2">
        <location>
            <begin position="32"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="343" mass="36447" checksum="7A571AE4ECE36644" modified="2021-04-07" version="1">MNVRRLIPTTAVAGAVVLGLTALSACSTSDAADGGNGDKLKVTASFYPMQFLAERIGGEHVAVTSLTKPGVEPHDLELTPRQIGSISESDYVLYLKGIQPAVDDAIQQSGVKNTVDAATLTTLENHGAEVSGHDHGHEGEEEHADEHGHEGEEAHEEHSEGDGHNHGEEGGADPHIWLDPVKYAEVAKGVGKSLEKADPDHAADYKKNTEALVGELDKLNTAYETGLKNTATKTFITTHSAFGYLAERYGLTQQGIAGIDPEAEPTPARIQELHTIAEKEKATTVFFETLASDRTAKTLAKDTGLKTGVLDPLEGITKKSQGADYIEVMESNLAALQKALGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS53</accession>
    <name>A0A7K2ZS53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001767">
        <property type="protein sequence ID" value="MYW35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="7024" checksum="E37D91918C0EB73D" modified="2021-04-07" version="1">MPVPTSMVVGAHWVTADEYKAAHGLAPSRSLASSALRESFSARSVAQVGTAAWQRFEAARALPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSC3</accession>
    <name>A0A7K2ZSC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4229 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025323">
        <property type="entry name" value="DUF4229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14012">
        <property type="entry name" value="DUF4229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="10662" checksum="304AAFA7340C8021" modified="2021-04-07" version="1">MSAAKPSAMIRYTALRLLIFVGCFFIAGVAVHFGLVPSGLGGSNVVWVMLLGLVLSAPLSFVLLRKQRDEMSEQIVTKVDRTKARLDANRTREDLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSK1</accession>
    <name>A0A7K2ZSK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001834">
        <property type="protein sequence ID" value="MYW35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035214">
        <property type="entry name" value="DUF5324"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17258">
        <property type="entry name" value="DUF5324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="25384" checksum="32EF18CD12263C3D" modified="2021-04-07" version="1">MTRIDSVRAATDSARDSAQHAAEVVAPYADTAKKQAAHYAHEARVQLAPKVTKAAKQARVQYESHLAPRLEQALTHVPPKVDEAAQRAAHSTRKAARTAADYTAPRVEHAKAVAVPVAEQATARSAAALAALRSNVTAKEIQKLARKHERRARAGRATKGLLVLGIVAGGAYAAWRWWDKQANPDWLVEPPVATEVGDDRSPLSSVDGSGQAVLDPEVKAKQAEAEANGDTPGLDDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z691</accession>
    <name>A0A7K2Z691_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000034">
        <property type="protein sequence ID" value="MYW27859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="11753" checksum="52AD69758313A011" modified="2021-04-07" version="1" fragment="single">MRDSHRADAERLLVRAVEEEARRTGGRTDSGVLLARARAAFDTIAAGAGEEYAAYTQALDTAAAGDRPLAERLSRENLSTPLLVTGVAAVAAFGADLAFGTATAPALGAGAVVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6G7</accession>
    <name>A0A7K2Z6G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_01255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000057">
        <property type="protein sequence ID" value="MYW27935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003967102.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="63981970"/>
    <dbReference type="GeneID" id="66954941"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW27935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7103" checksum="2D31E72CE21F87EC" modified="2021-04-07" version="1">MATGTVKWFNAEKGFGFIAQDGGGPDVFVHYSAINASGFRSLEENQVVNFDVTQGPKGPQAENVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6N1</accession>
    <name>A0A7K2Z6N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000069">
        <property type="protein sequence ID" value="MYW28007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="34636" checksum="C3474BC0D946BE5D" modified="2021-04-07" version="1">MGPSSPPEAPDSTPVPDSDPVPDSALPTGSDLAGRVALVAGGTRGAGRGIAVQLGAAGATVYVTGRTSGSERSEMDRPETIEETAALVDAAGGRGIAVQVDHLVPDQVSALVARISGEQGALHILVNDIWGAEIEWNKSVWESSLDTGLHTLRLAVDTHAITSHFALPLLIETPGGLVVEMTDGTNEYNADNYRVSFFYDLAKAAVNRMAFALSHELAPHSATAVALTPGWLRSEAMLQAHGVTEATWRDAIAHAPHFAISESPAYVGRAVAALARDPEVARWNGRSLSSGQLAQVYGFTDVDGSRPDAWRYLTEVQDPGLPADVTGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6U6</accession>
    <name>A0A7K2Z6U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000086">
        <property type="protein sequence ID" value="MYW28067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511286.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000086.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="89" mass="10243" checksum="20AD8DECB5E712F1" modified="2021-04-07" version="1">MARDYDSQLLESVGVRRRRMRDALLFGVERARRTADERLGKVFAGIAITAVLCAGCVGWSFLQHTLDKQKAEQQKQQQRQAQQYEQPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7T3</accession>
    <name>A0A7K2Z7T3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="9">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gap</name>
        <name evidence="11" type="ORF">GT040_03715</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000155">
        <property type="protein sequence ID" value="MYW28401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="332" mass="34818" checksum="33AD5568304DFADF" modified="2021-04-07" version="1">MTRIAINGFGRIGRNVLRALLERDSALEVVAVNDLTEPAALARLLAYDSTAGRLGRPVTVDGDTLVVDGRRITVLAEREPARLPWAELGVDIVLEATGRFTSAEAARAHLDAGAKKVLVSAPADGADVTLAYGVNTDAYDPAAHTIVSNASCTTNALAPLAKVLDDLAGIEHGFMTTVHAYTQEQNLQDGPHRDARRARAAAVNIVPTTTGAAKAIGLVLPNLDGKLSGDSIRVPVPVGSIVELNTTVARDVTREDVLAAYSAAAEGPLAGVLEYSDDALVSSDITGNPASAIFDSALTRVDGRHVKVVAWYDNEWGFSNRVIDTLELLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7T4</accession>
    <name>A0A7K2Z7T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000159">
        <property type="protein sequence ID" value="MYW28417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21743" checksum="BC2E0E62F6AD5042" modified="2021-04-07" version="1">MRSHGYEHEHEHGPGHFGPGHHGRGGHDGRRAAFGPFGPPFGGGPFGGGRGRGGGRGRARRGDVRASILALLKDRPMHGYEMIQEIGERSGGAWKPSPGSVYPTLQLLEDEGLIVSASEGGKKLFTLTDSGRGEAESGPEAPWEEAGRGADWEGVNEIRQAGFGLMEAFGQVWKTGSADQRQKALTVINDARKKLYLILADEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Y7</accession>
    <name>A0A7K2Z7Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000160">
        <property type="protein sequence ID" value="MYW28423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14014" checksum="2E15EF8BA316E6BB" modified="2021-04-07" version="1">LARTVAYVKEREQFGRAIGSFQAVKHRLADLYVRVEAARSAAYHAAWDPAAGPLALAQALEAARTVAGEAVQLHGGIGFTWEHEAHLYVKRAAGDELLFGPVHRLRDHAAGQAGLFGDVTPDGLVHGVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z852</accession>
    <name>A0A7K2Z852_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS5/IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_04250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000194">
        <property type="protein sequence ID" value="MYW28502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="136"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="233" mass="25746" checksum="906A3EC044674BEF" modified="2021-04-07" version="1">MDIKQARVAIAHPAFCGISHQHLGKLIEELAPRCESGRHERRAGARQREIGAGPNDELVFVDRVLVTLVHLWTGLTHAALGVIYEVGSSTVGGAISEVRQLLAARGFAVPDHPGIRLRTLEDVFAYADAKGVCLRIDGMETQVRRPRTGRPGRRAFISGKRRQNTIKTTTISDHQGRTLWSGAERPGRMHDQTAVRTEGIAEQFRQYPQAKAEVDEGYRGLANEFPGQVSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8I4</accession>
    <name>A0A7K2Z8I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000233">
        <property type="protein sequence ID" value="MYW28670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="326"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="532" mass="57922" checksum="87055233EB9F9367" modified="2021-04-07" version="1">MITASGIELRAGARILIESASFRIAKGDRIGLVGRNGAGKTTLTKCLAGEGTPAGGTITRSGEVGYLPQDPRTGDLEILARDRILSARGLDEILRKMRENEERMANGKGATREKAMKKYERLETEFLTKGGYAAEAEAATIAAALSLPDRVLGQPLHTLSGGQRRRVELARILFSDADTLLLDEPTNHLDADSIVWLRDYLKNYRGGFVVISHDVDLVETVVNKVFYLDANRAQIDIYNMGWKLYQQQREADEKRRKRERQNAEKKAATLNAQADKMRAKATKTVAAQNMAKRADRLLSGLEAVRVSDKVAKLRFPDPSPCGKTPLMAEGLSKSYGSLEIFTDVDLAIDKGSRVVILGLNGAGKTTLLRLLGGAEKPDTGQIIEGHGLKLGYYAQEHETLDPDRTVLENMRSAAPDLDLVQVRKTLGSFLFSGDDVDKPAGVLSGGEKTRLALATLVVSSANVLLLDEPTNNLDPASREEILGALRTYKGAVVLVTHDEGAVEALQPERIILLPDGVEDLWGADYRDLVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8K3</accession>
    <name>A0A7K2Z8K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II toxin-antitoxin system PemK/MazF family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000240">
        <property type="protein sequence ID" value="MYW28680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="9512" checksum="1F3F8D74A543C957" modified="2021-04-07" version="1" fragment="single">MWWADVPYEDGPGSKDRPCLVLSVRGRGRGRTVIVAKITSKHHEERPGVIALPAGTVGDQRGRQSFLETDELREVALGGFRRRVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8N6</accession>
    <name>A0A7K2Z8N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000242">
        <property type="protein sequence ID" value="MYW28682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="7622" checksum="D221AEC67859B5A7" modified="2021-04-07" version="1" fragment="single">LRAARAGDPSYRTADLVTALAELLGTAHRVGTASGAELAAVRGRARRPYSPDGSLRLYGLFTEPVVTDSGHGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z949</accession>
    <name>A0A7K2Z949_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_05945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000259">
        <property type="protein sequence ID" value="MYW28825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241329.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000259.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="36939" checksum="80272CBEA0B2AFA9" modified="2021-04-07" version="1">MAAARVRNGGRPTLEEVAARAGVGRGTASRVINGSPRVSEATREAVEAAVAELGYVPNRAARALAGNRTDAIALVVPEPETRFFAEPYFSAIVRGVGAALADTDMQLLLTLAGNDRERRRLAQYLTAHRVDGVLLVAVHADDPLPELLEQLGMPCVISGARHANEPLASVDSDNFDGARAAVEHLITRGRRSVATITGRLEVYGAQRRLDGYRAALAAAGLPPDERLIAPADFTEEGGARAMRELLARRPHLDAVFAASDVMAAGARQVLREADRRIPEDVALIGFDDSVVARHMHPALTSVRQPIEEMGRRMAQLLLEEIAGRVGEERPTVVLPTELVVRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9B8</accession>
    <name>A0A7K2Z9B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000299">
        <property type="protein sequence ID" value="MYW28937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="21431" checksum="369292070D8E369F" modified="2021-04-07" version="1">MGLLDAILGRSKPVRPDLDQLFAVPSAALTLQAATGFTPTGLGSVCFAGVEGGGFARLQEDVRELLDADTERGGIPVEFSRDAYGYTWLLATHPADDTAGLVNDLHAVNTLLQDGGFGPHLLCSLIGFRDADTADAAEGRSLALVYLYKRGTFYPFAPLPGDAEKRDNQLELQVRGALGDDLRVEKDLSRWFPVWGAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9G8</accession>
    <name>A0A7K2Z9G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_06815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000305">
        <property type="protein sequence ID" value="MYW28993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PTHR21325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029689481" evidence="4">
        <location>
            <begin position="29"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="5">
        <location>
            <begin position="71"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="310" mass="32593" checksum="D1EFF39C3E74B02F" modified="2021-04-07" version="1">MTERATRPRMRTAGAALAALSFVGVAALAGCSGEGSGDGVSQRASAAASSSPSPSPSPASGWNPKPGSVAAVGDSITRGFDACSVLADCPEVSWATGSDSLVRSLAVRLIGPAKAVDRSWNHAVSGARMAQLPEQMALAAKERPELVTVMMGANDACRDSVGLMTPVADFRASFEASMRQLRAGAPKAQVYVSSVPDLKRLWSTGRLDEGAKRIWSLGICRSMLAEADDLGPAAAARRDAVQERVVAYNGVLRDVCAKDRHCRYDGGAVFGFRFTGAQLSPWDWFHPSRDGQARLAEIAYRNITAAEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9K1</accession>
    <name>A0A7K2Z9K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000312">
        <property type="protein sequence ID" value="MYW29023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="11256" checksum="2EE74F957DCE4083" modified="2021-04-07" version="1">MEPNDATTIPATCTHTHLFPGAHCRLQGLPDPTAFAATPHPIDIYLRFPDGAATDAELLTETPAGPALKVPAYTTGAGTAIDARTWTVRDVTATGDEVELTIGARSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9M9</accession>
    <name>A0A7K2Z9M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000324">
        <property type="protein sequence ID" value="MYW29066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="14544" checksum="0BA8034BC07ECC54" modified="2021-04-07" version="1">MSQDETDTTGDGEQPAELPEYAERVLDVADLIPPGRVMTYGDVAEWLGDGGPRQVGRAMALYGSAVPWWRVVRADGALLPGHELRALDHYRAEGTPLREASRQSDGHLPRLDMRRARWDGGPADGQGEETHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA16</accession>
    <name>A0A7K2ZA16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000359">
        <property type="protein sequence ID" value="MYW29179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561417.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000359.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14719" checksum="E9B8C07171767443" modified="2021-04-07" version="1">MTEKTALTPSTHTTPPAKFSHGVRKGNILQVAGQVGFLPAVEGQAPTPAGPTLREQTLQTFANVKAILEEGGASWDDVMMMRVYLTDVDHFAEMNEIYNAYFAEQNLKEAPSARTTVYVGLPKGLLIEIDALAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAG6</accession>
    <name>A0A7K2ZAG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="22121" checksum="A4548D1F33C6E164" modified="2021-04-07" version="1">MADMDAFREAVTAWAAGGPGEAARDLAGQLPVRTAVLLEGPSDAAAVNALAERRGRDLAAEGVCVLPMGGAMSVARFAGLLGPPGLGIRLTGLCDERERGFYERGWERAGAGAEQEFFVCAADLEEELIRALGVPRVEELVQAEGDLRSLQIFLRQPAQQGRSPQQQLRRFLGTKKGRKIHYGRVLVEALDAEQVPAPLDDLFATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAL8</accession>
    <name>A0A7K2ZAL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_08975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000410">
        <property type="protein sequence ID" value="MYW29407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="23285" checksum="ED36164B36A391DF" modified="2021-04-07" version="1">MNTLSETWSWLTTATHWSGPDGIWNRLGEHLFLTVVCLLISCLIALPVALVLGHLGKGGALAVNISNIGRAVPTFAVLVLLLLTPVGTYGQWSTIIALVLFAVPPLLTNAYVGMREVDRDVVRAARGMGMTGRQMLWSVELPLALPLILTGVRIAAVQLVATATLAALAGGGGLGRIITAGFNLASTPQVVAGAILVAAFALLVESLFEAGQRMAPSRGREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAR1</accession>
    <name>A0A7K2ZAR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000419">
        <property type="protein sequence ID" value="MYW29461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6509" checksum="0D2158EF151444E1" modified="2021-04-07" version="1" fragment="single">MTQNTPLSPLSARLPRPPHHVQDVTHRVLSAAQLRARGVSAAQTSAQCLPGGPWQHLLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAR2</accession>
    <name>A0A7K2ZAR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">sepF</name>
        <name evidence="6" type="ORF">GT040_09165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000417">
        <property type="protein sequence ID" value="MYW29440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="15884" checksum="B297EAB08C205421" modified="2021-04-07" version="1">MGSVRKASAWLGLVEDNDERYYDDEYAEGTETGTGNQAWVTDPRVQVAAEAAEEQDRRIATVTPDSFRDARAIGELFRDGVPVIVNLTAMDPADAKRVVDFAAGLIFGLRGSIDRVATRVFLLSPADTQVVAGEAAGRKADGFFNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAT8</accession>
    <name>A0A7K2ZAT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_09155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000416">
        <property type="protein sequence ID" value="MYW29438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="663"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="774"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="857" mass="91198" checksum="F7D7981717A8E3E4" modified="2021-04-07" version="1">DDFFDLGGHSLLATQVIARARKRLPEVGARPVSVMDLFTSRTVRELAALADLDESERGPRHLLHRLTRATPADARVLSYVCIPYGGGSAVVYQPVADELPPGHDLWSVAIPGHDMGVTEEHLPFDELAAKIAAEIRERVEGPIALYGHCAVGSALTVAVGRLLEAADREVEALYIGAQFPFARPRGRVLGLLSRVSALDPLLNDRVYFTWLRSMGAEVGDLDEAQMKFMIGNMRADSRAAEEYFTEVLAEVEEGGDLLRAPVISVIGNRDPATDFYQERYREWQLLAERSALAVLDEGGHFFLKYRARELVEIITSTHRAILAGTASRELPRQAEDGPWWFHGVSGGDGPDEAGADDVWTEESAPAGGEGSPDAAAGPDTGPAPGMGRFLAVALGQLVTITGSALTEFALPVWIYMETGSMGKYALYAVIGMLPGILVGPLAGAVVDRLDRRRVMLAASAVAGTTQGALLTLLLSGNLHSWHIYVLLGMLSVALTFQRLAYASSVPQLVPKRYLGHANGITQMAFGFAQFIVPLAAVALMAGIGLKGILILDVTGYAVAITVLMLVKFPKTLPWTRRESLIAEIRNGFAYSWKNRGFRAMLLWFAALNIFLSPLFLLVTPLVLSFDSLESVARVAVAGGAGAILGGIAMGFWGGPKRNRMRGMLTLAGLLALASALVGVRADLWIIGIGAFGMSCALSMVNGVYTTIVQIKVPQRFHGRVFALNTLVAWSTLPIGHGIIAPAGSAFFGPMFEDGGSLASTAGALIGTGPGRGIGFMYLLFGAAMLGLVVIGLRLPVLARFDLDVPDALPDDLVGIQERERRVAERAKRTPSGPGDAPPKDPAVPAGMVGAGGTGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAU0</accession>
    <name>A0A7K2ZAU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000418">
        <property type="protein sequence ID" value="MYW29454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7769" checksum="8EC5AC5B82C0FE66" modified="2021-04-07" version="1">MAKALLGYVGGSDPRLLAEMRRLQQRVQDLESELNRIQDENDALNAAAQHQESLLDSIDIDVHQGEPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBC6</accession>
    <name>A0A7K2ZBC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000464">
        <property type="protein sequence ID" value="MYW29633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="233" mass="25441" checksum="D3556811C0943748" modified="2021-04-07" version="1">MLDAVDRLRRAADEQHRTSRTVRLGTVFAATVPLLVPAIREFHALHSATEVEVIAAQQSVIHRSLLEGGVDLGLVNYLEGDDLAPDLHTTELLRGRPVVCLRPDSPLASLESVGVDDLLSEPLIVMRSGYLMHRFTHRLLKGRVPSFSYSADGAEMGKLMVAEGLGVTVLPDYSVVGGPLERTGAITCRPLKDDTTTVLLVVQRSRSGSVTRAARDLHRIFVERAEAHRTAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBN6</accession>
    <name>A0A7K2ZBN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046251">
        <property type="entry name" value="DUF6284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19801">
        <property type="entry name" value="DUF6284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="89" mass="9580" checksum="2C324CE86EAC0AE6" modified="2021-04-07" version="1">MKNIAALQAAVTATPSEREPSDAELDAIETESPLILADVALLDAQIMTIDRTPTELDQQRIRRARRRVLAARRDLANRAATVTVSGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBR8</accession>
    <name>A0A7K2ZBR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_11080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000501">
        <property type="protein sequence ID" value="MYW29811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030571706.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000501.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="313" mass="32702" checksum="A142C7C1A7C0C2EE" modified="2021-04-07" version="1">MGAGHDHGHTHGGPPPTGTAAAAYRGRLRVALGITLSVMVMEIVGGVLSDSLALIADAAHMATDALGLGMALLAIHFANRPAGPNRTFGFARAEILAALANCLLLLGVGGFLIFEAVDRFITPAETKGGLAIAFATVGLVANIVSLSLLMRGQKESLNVRGAYLEVMADTLGSLAVIVSAGIIMATGWQAADPIASLVIGLMIVPRTVKLLRETLNVLLEAAPKGVDMAEVRAHITALPGVLGVHDLHAWTITSGMPVLSAHVVVRQEMLDSIGHEKVLHELQGCLGDHFDVEHCTFQLEPSGHAEHEAHLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC64</accession>
    <name>A0A7K2ZC64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000530">
        <property type="protein sequence ID" value="MYW29898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16499" checksum="5690D65D3F3D5101" modified="2021-04-07" version="1" fragment="single">MPAEPAPRMTAREAIALLTDGTGFTEHRPPPRTLPPDGPLGWAGYDAARERAAERTGEEESVVYGAGVVGDRECVLLSFEFGFLGGSLGQLTGDRLEAAYELALSRRLPLLALVATGGSRMQEGMVALTQLQRVAAASTRLRAAGLPQIAVVRDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCD9</accession>
    <name>A0A7K2ZCD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000548">
        <property type="protein sequence ID" value="MYW29968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="444" mass="48575" checksum="CEC0B7B20075EACF" modified="2021-04-07" version="1">MTGMLDGGTLLTADDGDSVRVIDMLGAGGQGEVYRVATASGERALKWYYPSCATPEQSDIVRELVARDFDDDRFLWPTAYVPSGTGGAFGYLMDLRPDRFKGLPDLFRRRLRTTPRALLAAALYTVEAYQALHSRGIAYRDISWGNIFFDPATGEVLVCDNDNAVVEGDTTGISGTMEFMAPELVRGEKGARPGTQSDLHSLSVLLFMLLMNHHPLKGKRELEIHCLDEAAEKRLYGKQPLFVFDPADQANAPDPVEQSTVLHTWAAAPPALQDLFTHNFTVGLHQPTARVRESQWRDALRSVLDATVDCADCGRQNMTQPAATTAGTCWSCGSSLILPPRLSIVTPLPRSERHVRLRRDARVHEHHLAPEPSRHDYSDATLVAELTEHPSRPGKFGLANRSSTSWTGTRSDGTSQEIAPGQTVPLRAGLRLDLGGAQAAVHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCE4</accession>
    <name>A0A7K2ZCE4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000560">
        <property type="protein sequence ID" value="MYW30024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="10159" checksum="6E979BFA72EE3F06" modified="2021-04-07" version="1">MAYEIPVTQARAELADLINRVVYGGERVVVTRHGKPLVALVSAADLERLEGLDGEGAAGEQQVIGSVSSIRSAAPAAPGERQRFGIAAEHRGQGDPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCG6</accession>
    <name>A0A7K2ZCG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysE family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_12235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000560">
        <property type="protein sequence ID" value="MYW30029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="22125" checksum="71260FC1A7B74E4D" modified="2021-04-07" version="1">MDAQLIAFTGVAAGMVALPGADFTVVVRNALASRTAGLATALGVAGGLLVHTALAVAGLAAVLVTMPVLFRTVQLLGGAYVLYLGISALYAIRRRVSEEGRTPEQATGPEEPEGLGRALRQGFLTNALNPKAPVLFLSLLPQFVPAGQPPLPRTLLLAALVVALALVWFSALALLVDRLGRWLRRPRTARAIEGGSGVALTGLGLALVTGPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCS1</accession>
    <name>A0A7K2ZCS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19362" checksum="6B5995067689044A" modified="2021-04-07" version="1">MTKPSLSEGRSLARELDSARLRLRAAHKERRHAEDAIAIERRRIHLLEAQSLADPEHDFGDLSILLRDVEPEELKGFSPTCISCRAPMSSEAAVEPCPGDTHVCPAATEEGATPTAFEQYGRDGWWCGQSGSFNAAGTNWECASGHSTDRPCEGHPWSMRKCLGSCPCRDLGRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCW2</accession>
    <name>A0A7K2ZCW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000601">
        <property type="protein sequence ID" value="MYW30159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="435" mass="46500" checksum="BBE74BE078C94364" modified="2021-04-07" version="1">MDRALQGLVAQSVVQRDGTRYRMLDTLREYGRMWLAELGEEGAAADRHARSFLGLSRRAHEGWTGPDQITWYHTIADAHLDLCAALDHLLAHDVAGAQEMAGRVGFFWACCGHLSEARGYAQRALEAGPVEGPHRTRLQWVLGVAALLQGDFATAEKYGALCTAIALYDHDDEGMLGATYLSGLTQLMNGEPAAALEAAERVLRMTETAPPDGGPDGRRATATDCATDTTSESGACEPTASEPGACEPGASEPGWDSAPLESAHRLRCRLITVFALTALGRLTESGRAAAALRRSCERGGEYWTRSYADYQLALIALLQDRPEASAAHARAMLAGKHRLRDSFGIALGLDILAAALAAQGAGAQAARVYGTGHAYWRMVGHPQRGTPELGPVRETCELQARAAVGDEAYQRAFERGQADNAEVGLAAALHSDLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD10</accession>
    <name>A0A7K2ZD10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000618">
        <property type="protein sequence ID" value="MYW30247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="614" mass="66946" checksum="2DC307560DC5ED54" modified="2021-04-07" version="1">MPVIPFPAPRTLTTTPGGARLDAPVRTTVAPGLPVQGYRLRTGPDGVSIDHRDALGLRYALHTLDQLRAGQDYTGTGYDIGDHPDFPVRGFLLDISRDRVPTRRTLARWIEILALARYTQLELYTEHTFAFRDHQEVWRDASPLTADDLRWLDGRCAAAGIELVANQNTFGHMERFLRHPRHAHRAESPEGFERGGVHRPPSTLEPTDDNAAFATALVAEVAREVRSQHLNIGADEPFELGRGRSADRVARQGAGEVYFDFVTRLMEPWLASGHTVQFWADVFAGHPELMDRVPPGAVPVVWQYDGPRLLAEVTDGDTPEARTWQRLGADLDNLREGFRSRGRLLSEAGVPFWVAPGASNWNSLLGRIDNAVDNMIDAAETGRENGAEGFLLTSWGDHGHWDPPSVAYGPVIHGGAVSWCLEANRDLGIAAVLDEHVLLDEARLTGDVLMRLGRVHRDLEVPLLNASPIARALFPDPAVPLPSIPPPEALDRVAATLAACRDDLAAAAPAAADGDTVRRELQHAISLAEFALDVLRGRAVAAFAGAAAETGAEAAVAGADAIDGPTARRLLRRIEPLLTEQRACWLLRSRPGGLEDSIGELDRLRHQLLKAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDR3</accession>
    <name>A0A7K2ZDR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SWF or SNF family helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000682">
        <property type="protein sequence ID" value="MYW30476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="23245" checksum="112255C52CF9A976" modified="2021-04-07" version="1" fragment="single">MSEDDEYGTDVVDSGGGAERTFAPLPPPPGRGFATSWWGRAWLQALEDTALDGQQLKKGRRLAREGGVGAVSVRPGRITAVVRHRDGTGHRSDVLLQELGDEAWDRFLDMAVERAGHIAALLDREMPPHLVEDAAGAGVDLLPGIGDLEPECTCGAWDHCPHSGALCYQVARLLDEDPFVLLLLRGRGERRLLDELQVRSAARAVRGAGGDAPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDS8</accession>
    <name>A0A7K2ZDS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000683">
        <property type="protein sequence ID" value="MYW30478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029479698" evidence="1">
        <location>
            <begin position="35"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="32349" checksum="E61A319BB7DCD9DA" modified="2021-04-07" version="1">MKKTLLLATATALLVPAAVLAPQAAAGSASPAAAPTYKVNTFERPAAGNSYPLSQWAADGWNAPWQQGMETRARIDNTTPAHSGSKSLRIHYPKGKIGPEDSGAQAPFALTKAREYYLSFWVKFSGDFSWGTTEYAGKVGLGLAGGASCSGGQVCDGKNGFSSRMIWRQNNGQAAVYYYHMGHAGQYGDYAVLKNNGADIHWPKNQWVNVAQRVKVNSVSNGNANADGEIEVFYNGRSAAKVTGLRFVTNNDQVDRAYFSSFAGGATPSFAPNNNNSYIWYDDIKVSTDRNDICELNSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE05</accession>
    <name>A0A7K2ZE05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="33"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="24136" checksum="5967B8A2C20973CE" modified="2021-04-07" version="1">MGQPESREYRESEQSELPPGQRLQRGWPVTHYGPVPKFKPERWEFRVFGATADGDKHCWNHQDFSALPFSSVVADLHCVTKFSMIGAEWGGVLARTVLDLAPPAPDVTHVMVWAEYGFSSNLRLDDFASERTLFATHKDGELLTAEHGFPLRLVVPHLYAWKGPKWVRGVEYMTTDRRGFWEERGYHNIGDPWSEQRYSYQEEPGDGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE51</accession>
    <name>A0A7K2ZE51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000722">
        <property type="protein sequence ID" value="MYW30630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="27772" checksum="90FA1A778FF53776" modified="2021-04-07" version="1">MNDLGAGFGYLMKGQRWVLGHGRWFGFGLLPGLITLVVYAGALVGLGYGADDLVAWATPFADDWSSPWLGLLRTTLTALVFVFGLFLAVITFTAVTLLVGQPFYESLSEEVERGEGGEVHESGLPLWRELWISARDSVRILLRVALFGIVLFACGFIPVVGQTVVPAIGICVSGYFLAEELTGVALQRRGLHLKKRLGLLRTRRLLVLGFGVPLALSFLVPFVAVFLMPGAVAGATLLARELVDPAGSGDTAAPKTWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE62</accession>
    <name>A0A7K2ZE62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_15470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000724">
        <property type="protein sequence ID" value="MYW30641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03859">
        <property type="entry name" value="M14_CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033810">
        <property type="entry name" value="Carboxypeptidase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029510187" evidence="2">
        <location>
            <begin position="46"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="4">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="461" mass="50082" checksum="6320C4E995D1ED9E" modified="2021-04-07" version="1">MRLANTRKSRSAKARTKAGATRTKARRNATLAVLLALGLAAPASAVATAEPADRKTVVATAERPVQYEITGRTTPAVRTEILRAGVTIDEVHDHGIVISASTAQAKQLRAKGHLLEALPAPDAHAHGADGVGALDFPPADSRYHNYAEMTAAIDARIAANPSIMSKRVIGKTYQGRDIVAIKISDNVGTDEAEPEVLFTAHQHAREHLTVEMSLYLLREFATGYGTDSRITQAVNGRELWIIPDMNPDGGEYDIATGSYRSWRKNRQPNSGSSAVGTDLNRNWAFKWGCCGGSSTSPSSDTYRGTGPESAPETKVVADFVRSRVVGGKQQIKAAIDFHTYSELVLWPFGYTYNDTAPGLTADDRNAFATVGRKMAASNGYTAEQSSDLYITDGSIDDWLWGSQKIFGYTFEMFPRSASGGGFYPPDEVIERETSRNRDAVLQLIENADCMYRSIGKEAQYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEG4</accession>
    <name>A0A7K2ZEG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ORF">GT040_16005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000756">
        <property type="protein sequence ID" value="MYW30740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="402" mass="41195" checksum="7CE7F20B3E5851EF" modified="2021-04-07" version="1">MTGTGADTGLTSRWQGALMDNYGTPRLPLVRGEGAYVWGEDGTRYLDFVGGIAVNALGHAHPAVVEAVSTQVASLGHVSNLFIAEPPVALAERLLQLFGRPGRVFFANSGAEANEAAFKIGRLTGRGHMVATDGGFHGRTMGALALTGQPGKQEPFVPLPGDVTHVPYGDVDALRAAVTTDTALVVIEPIQGENGVVVPPKGYLEAAREITRATGTLLVLDEVQTGIGRCGQWFEHQAHQGVEPDLVTLAKGLGGGLPIGATVAFGPAADLLKPGHHGTTFGGNPIACAAGLAVLDTLAADGALDQVKRLGERIRDGVEALGHPLVSHVRGSGLLLGIVLTGPLAPQVQQAAQGAGLLVNAPAPDVVRLMPPLIIGDAEVDAFLEILPSALDAAHGDGRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEJ8</accession>
    <name>A0A7K2ZEJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000757">
        <property type="protein sequence ID" value="MYW30756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="268" mass="28637" checksum="809D99CB10C33941" modified="2021-04-07" version="1">MTYANAEDCSPQLRGALEAVIGGYMAAVAEVLLAEEIPVVSVSAYGDVHDPSQDDFEGDAEGSVEFTSAFGRALLGDGGEAGLLWCGVSGWCFFRIPEGSGRSLLDSARWMGSGLTPEPVRVAAFLSEVRLDPREAGSAERPFYRAPHSEPDILLRRLEAFGALDGGAEPWAWAGEGQAVAHLRSTACRRRAVEALTAADQEIAELALHTGELDALAGLLAYAEGDTPDDGLREPARRLARDLALRARDGVESVDERREAFSYAEEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEN2</accession>
    <name>A0A7K2ZEN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-II family nitrogen regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_16385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000764">
        <property type="protein sequence ID" value="MYW30810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006127894.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000764.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="112" mass="12267" checksum="98009B9C6BD826C6" modified="2021-04-07" version="1">MKLITAVVKPHRLDEIKEALQAFGVQGLTVTEASGYGRQRGHTEVYRGAEYTVDLVPKIRIEVLVEDEDAEQLIEVVVKAARTGKIGDGKVWSVPVDTAVRVRTGERGPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEW7</accession>
    <name>A0A7K2ZEW7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable M18 family aminopeptidase 2</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">apeB</name>
        <name evidence="12" type="ORF">GT040_16640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00467">
        <property type="entry name" value="Aminopeptidase_M18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022984">
        <property type="entry name" value="M18_aminopeptidase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW30858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="432" mass="46285" checksum="42FE206DA4E5CDFF" modified="2021-04-07" version="1">MSSRHRFDRAHTDDLMSFLAASPSPYHAVANAAARLEVAGFRQVEETAAWDASTGGKYVLRGGAIIAWYVPEGASAHTPFRIVGAHTDSPNLRVKPLPDTESYGWRQVAVEIYGGPLLNTWLDRDLGLAGRISLRDGTDRLVNIDRALLRVPQLAVHLDRSANTDGLKLDRQRHMQPIWGLGEVSEGDLIRFVAEEAGVDAEDVTGWDLMPHPIEPPSYLGRDRELVAGPRMDNLLSVHAATAALAAVAGQPDEELPYIPVLAAFDHEETGSQSDTGADGPLLGTVLERSVFARGGTYEDRARAFAGTVCLSSDTGHAVHPNYAERHDPTHHPVANGGPILKVNVNMRYATDGSGRAVFAAACEKAGVPLQTFVSNNSMPCGTTIGPITAARHGIMTVDIGVAILSMHSARELCGADDPYLLANALTAFLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF51</accession>
    <name>A0A7K2ZF51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3558 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000804">
        <property type="protein sequence ID" value="MYW30929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029861990" evidence="2">
        <location>
            <begin position="33"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="29174" checksum="A9B734F077F1DEAF" modified="2021-04-07" version="1">MHRSAPRLSRILACAAVPVMLVAVGCSSDSGSGSGSDAEKKAGSSSSSDSAGAEPTKPAVEPAKFTDLPDACTSIAKNTVKDLVPEAKKKGGTAGRSSDLAVRGSCSWNGLDDKGVKGSQYRWLSVAFTRFDSDQSLGSGAARATEDYTKQVAKEKASEGAQKAAAAAAPGIGDEATAITYKLNKTDEDFEYATVVARTGNVVVTLTYNGAGYAGAKTPSAADILKGAQKAAKEAVGKVDATAGAGSAEASPSAGDAKKDDKKEEKKDDKNGDEKGGEKPASEATPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF94</accession>
    <name>A0A7K2ZF94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VCBS repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000820">
        <property type="protein sequence ID" value="MYW31037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="396" mass="40595" checksum="D0040016B038F3AB" modified="2021-04-07" version="1">MRTRITHPKATATASTWAATTTRATTATRAAASLAAGCVGLLLVLTGCDSSSAADPAPSAAADAKNGDSAPVPAIPVPRGEGSRVPYDFNGDGHPDLVINDLVKAPEDPHGDDAGTGIVYGTEDSPLDPAARRLLNARANAAKSGDTRPAAFDAEAACDLDRDGFTDLIVSTDPPYNGVGAPPVPLQILFGSPEGLTGKAVTVRIPAQARFGKEWPEHPVCGDFDGDGSTDLAVTAGDGRISFLRGPFVRTGAPAGAALLPDGTPYLYAPEPKADTDGDGYDDLVATARPRTPGQAAEGTLLLGSADGPARPGGAYIFPAEELPEAPLRTKGTKGTKATEGTTRTTLLSHGDFDGDKKADTVVRTYRGGREDLVALYAAGNTDHPVLTFSTALFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFE8</accession>
    <name>A0A7K2ZFE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3152 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000838">
        <property type="protein sequence ID" value="MYW31081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3152" evidence="2">
        <location>
            <begin position="11"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="21167" checksum="74C3D33FC52CD7FE" modified="2021-04-07" version="1">PPADDDRPPKASDVPASGPGTFTVARAGITKSGKGEPYRVEVEDGIGVDPDRAAEDIAAILADPRGWSHGGERSFRQVIDKSAGLVVRIGTAATTDRLCGAYGLKTRGEVNCRGGEQVMVNLKRWQLGSPQFDGPVTEYRALIINHEVGHWLGRGHETCPGKGRPAPAMMQQIDGLKGCVANAWPYDAKGRYLGGPKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFH9</accession>
    <name>A0A7K2ZFH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">GT040_17835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000846">
        <property type="protein sequence ID" value="MYW31092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241705.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000846.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW31092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="84" mass="9413" checksum="00803F64B9E84429" modified="2021-04-07" version="1">MLINMVTEDALDWQETALCAQAGPEFFFPAPGSSTREAKQLCGACEGRVACLEYALANDERFGVWGGLSEKERERLRREERDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFM7</accession>
    <name>A0A7K2ZFM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_18050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000856">
        <property type="protein sequence ID" value="MYW31126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="25"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="52060" checksum="E9C88D18FD566E60" modified="2021-04-07" version="1">MSFFHELAHQYIDGEWRTGSGSWDIIDFNPYNGEKLAAVTVATALEVDQAYRAAERAQQEWAATNPYERRAVLERALRITGERADEIAEAITDELGGTRLRAAYEVRGASEALREAVRQSLRPTGRLLPAVSDGRENRLYRLPVGVVGVISAFNFPFLVGMKSIAPALALGNAVVVKPHQSAPVVGGGLIARIFEDAGLPAGLLNVLITDSAEIGDAFIEHPVPKVISFSGSDRVGRHIAATAAGFFKRTILELSGNSALVVLEDADIDYAVRAAVFSRFLYQGQVSMAANRILVDRSVAAEFTERFTAEVAALKSGDPRDPETRIGPVFNAFQADALTALVDRAVADGATALVRGRTRGNVVEPTVLTDLPDGSPLLTQEILGPVALLMTFDGEEEAVTIVNDSPYGLSGAVHTGDAERGVRFAQRIVSGMFHVNDSTVQDDPLVAFGGEKTSGVGRLNGEAVVEAFTTQKWMSIQHGRSVFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFV9</accession>
    <name>A0A7K2ZFV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uma2 family endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000866">
        <property type="protein sequence ID" value="MYW31216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="20846" checksum="FB0682227555A538" modified="2021-04-07" version="1">MGVRAVEPVPGHGQDWDDIVRIWEETDAPEGCKVEIIEEIVTVAPPPSDDHSATASPLQRPLCTVIPEGWGIYQTLGVALPGRGGIRVPDLVVLPRAAASGPGYHVPAVARLVVEITSRANADHDRVGKVNGYAKAGVELFLLLDPWHSGRPTATLYGEPESGTYRVLETVEYGGKISLREPFGLDLDTGVLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFW8</accession>
    <name>A0A7K2ZFW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000872">
        <property type="protein sequence ID" value="MYW31261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="21047" checksum="4D07D300F9E70269" modified="2021-04-07" version="1" fragment="single">MTGDYQELVDEISALLGAPATLENRDFGLVAFGAHDSDDDTAMDPVRTRSILTRRSTPAVRAWFEGYGITRATGPVRIPAAPEAGVFRDRICLPVRHRGVVLGYVWLLDTDPGPTDERLAAAMEVTARIGALLSDEARAGADLSREFGAVLTAGPGRQHDTAVAALREALGQDADGLHAVVCVTPWGADDTPSVRGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFZ0</accession>
    <name>A0A7K2ZFZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000870">
        <property type="protein sequence ID" value="MYW31252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="8469" checksum="0A63D1463C81F69B" modified="2021-04-07" version="1">MERDSQLKLYGQVADQLKEAHAKVRALQVPESVRMALSRKLLVVTAAAKHDLPDAARRLDRLMKDLDEGRFPEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGC7</accession>
    <name>A0A7K2ZGC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_19465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000910">
        <property type="protein sequence ID" value="MYW31392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="278" mass="29178" checksum="786CB97FBB8A16E4" modified="2021-04-07" version="1">MRTLRDLFAVRSRELPSPVAPGSPAVEAAGVSVRLGGRQVLDAVDIAAHAGEVVALVGPNGAGKSTLLAALAADLAPGSGEVLIGGRPATAWTAPELALRRSVLPQSAVLSFPFPVEDVVRMGRAPWAGTELEDEDDTAVAAAMSATEVTRFAARPFSELSGGERARVALARVLAQRAPLMLLDEPTAALDLRHQELVLRICRERAAAGDAVVVVLHDLGLAAAYADRVAVLHEGRIAVVGPPREIFDGELLGEVYRQPVEVFPHPRTGAPLVVPVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHD9</accession>
    <name>A0A7K2ZHD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dnaB</name>
        <name evidence="15" type="ORF">GT040_21385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030563034.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001015.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="14">
        <location>
            <begin position="226"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW31760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="492" mass="54111" checksum="6A8DDB90A45A1069" modified="2021-04-07" version="1">MSIPEPLDDPWTEAGPGDRLPVSRPRRGERKGNREDRHDRGSDDGWDGGSPGFERVPPQDLDAEQSVLGGMLLSKDAIADVVEIIKGHDFYRPAHETVYTAILDLYAKGEPADPITVAAELVKRGEITKVGGAPYLHTLVQSVPTAANASYYAEIVHERAVLRRLVEAGTKITQMGYAADGDVDEIVNSAQAEIYAVTEQRTSEDYLPLGDIMEGALDEIEAIGSRSGEMTGVPTGFTDLDALTNGMHPGQMIVIAARPAMGKSTLALDFARAASIKNNLPSVIFSLEMGRNEIAMRLLSAEARVALHHMRSGTMTDEDWTRLARRMPEVSAAPLYIDDSPNLSMMEIRAKCRRLKQRNDIKLVIIDYLQLMQAGGSKRSESRQQEVSDMSRNLKLLAKELEVPVIALSQLNRGPEQRTDKKPMVSDLRESGSIEQDADMVILLHREDAYEKESPRAGEADIIVGKHRNGPTATITVAFQGHYSRFVDMAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHS9</accession>
    <name>A0A7K2ZHS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_22205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001058">
        <property type="protein sequence ID" value="MYW31913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="302" mass="32953" checksum="80DF7602B232552B" modified="2021-04-07" version="1" fragment="single">QAFTMHGTIMLLMFATPLFAGFANWIMPLQIGAPDVAFPRLNMFAYWLYLFGSLIAVAGFLTPQGAADFGWFAYAPLNDAVRSPGIGADMWIMGLAFSGFGTILGSVNFITTIICMRAPGMTMFRMPIFTWNVLLTGVLVLLAFPVLAAALLALEADRKFGAHVFDPANGGALLWQHLFWFFGHPEVYIIALPFFGIVTEIFPVFSRKPVFGYIGLVAATIAIAGLSATVWAHHMFVTGAVLLPFFSFMTFLIAVPTGVKFFNWIGTMWKGSISLETPMLWSIGFLVTFLFGGLTGVILASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHU4</accession>
    <name>A0A7K2ZHU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001037">
        <property type="protein sequence ID" value="MYW31885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015607429.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001037.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="167" mass="18145" checksum="48FD62929AB64B0B" modified="2021-04-07" version="1">MGMSVIISAATAQDVEQIFRLQYLCFQREAELYDNYRIDPLVQTLDAVRGEVADDLVFVARLGDEVVGSVRGFTDPDGTGQIGKLCVHPRLQGHGLGTRLLNAAEAALAADRAATRFRLHTGHRSESNLRLYRRAGYAQVGDATGTDGVRLILLEKEAAAQEFVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI18</accession>
    <name>A0A7K2ZI18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_22670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001065">
        <property type="protein sequence ID" value="MYW32000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="28088" checksum="C0E500524A5679FF" modified="2021-04-07" version="1">MTTLRTEALSYGVGEGRHLVDAVDLTAADGETVGLVGPNGSGKTTLLRCVYGTLRPTHGRVLLDGDDLATLPVKARAQRIATVPQEGHAGFELTVGQVVAMGRAPHKRFWEADNAADTALVTEALARVGIAALEPRTFASLSGGERQRALVARALVQQPALVVLDEPTNHLDIRYQLEILSLVRDLGTTNLLALHDLNLAAYYCDRLYVLKDGRVVASGTPEEVLTADLLGEVYGVAAEVSTHPKTGAPTVIYLPEGPGRPAVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI91</accession>
    <name>A0A7K2ZI91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="14" type="ORF">GT040_22865</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01001070">
        <property type="protein sequence ID" value="MYW32035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="293"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="806"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="728"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW32035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="957" mass="105980" checksum="5048AAB13F2469B2" modified="2021-04-07" version="1">MSETNSAAETAAPHRYTAAMAADIEARWQDFWDAEGTYEAPNPTGDLAGDPELAAKPKKFIMDMFPYPSGAGLHVGHPLGYIATDVYARHQRMTGHNVLHTLGFDAFGLPAEQYAVQTGTHPRASTEANMENMKVQLRRLGLGHDNRRSFATIEAEYYKWTQWIFLQIFNSWYDAEADKARPIAELVEQFENGTRATPDGREWSGLSAAERADLLGQYRLAYASDAPVNWSPGLGTVLANEEVTADGRSERGNFPVFKAKLRQWNMRITAYADRLLDDLDGLDWPEAIKLQQRNWIGRSEGARVEFPVDTAGGITVFTTRQDTLFGATYMVLAPEHELVERIIPAAWPEGTHPVWTGGHASPAEAVTAYRKQAAAKSDVERQAEAKDKTGVFTGAYATNPVSGEKVPVFIADYVLMGYGTGAIMAVPAHDARDFAFARAFELPMRCVVQPSDDRGTDPSTWDDAFGSYDAKLVNSANDEISLDGLGVVEAKARITEWLQEHGVGEGTVNFRLRDWLFSRQRYWGEPFPIVYDEEGIAHPLPESMLPLELPEVEDYSPRTFDPEDADTQPETPLSRNADWVNVTLDLGDGAGPRKYRRETNTMPNWAGSCWYELRYLDPTNDRQLVDPAIEQYWMGPREGQPTGGVDLYVGGAEHAVLHLLYARFWSKVLHDLGHISSAEPFHKLYNQGMIQAFVYRDARGIAVPAAEVEERDGAFYYEGEKVSRVLGKMGKSLKNAVTPDEICAEYGADTLRLYEMAMGPLDVSRPWDTRAVVGQYRLLQRLWRNVVDEETGEVTVVGTEPGEDTLRALHKAIDGVGQDLEGMRFNTAIAKITELNNHLTKAGGPLSRSVAERLVLLIAPLAPHIAEELWRRLGHTDSVVHQDFPVADPAYVVDETVTCVVQIKGKVRARLEISPSITDEELEALALADAAVVAALGGAGIRKVIVRAPKLVNIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIU5</accession>
    <name>A0A7K2ZIU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001124">
        <property type="protein sequence ID" value="MYW32272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="346" mass="37765" checksum="F96C9290F3AD19CE" modified="2021-04-07" version="1">MTQHESTTPAESGAFRPSRRIFLRGAVAGTAATAGLIATGAGAAPAAAAPGGFPDYRYLKPLLTPSQLKYNPTGEIIFPCIRGVYDRLANPLGRYYLYYAPHDAPGGICLAYGDKLEGPFTEYTANPLVSNNWQPHYKVSHVSSPHVLWNEDVKELWLYFHGENHTTRLARSKDGISFTYDRTVLTKDMLPAGTTEASYARVFRHDLPARGARYVMLFMINNQSNRRDVGWGWSKDGRSWTFSQQPLIRHADVGANNISGGHLLTRGGSTYVVYHTGKESGGNILITEVGNDFSRRNHLGVFYDSGSAAPENGRAAAPSFGTDRGVPYMVYEAGERLGGSIAVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIY1</accession>
    <name>A0A7K2ZIY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_24245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001134">
        <property type="protein sequence ID" value="MYW32294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="317" mass="34450" checksum="CDD5973867182375" modified="2021-04-07" version="1">MSLFWRIFLLNAAVLVAAGALLLLGPITISTPVLLTEAMILTGGIAFMLAANAALLRLGLFPLQRVTRAMTTTDLLRPSPRPEVAGHGEIAALIETFNTMLDRLEAERATSSARALSAQEAERRRVAQELHDEVGQTLTAVLLELKRVADHAPEPLRGELRQVQEITRGSLDEIRRIARRLRPGVLEELGLVSALTALITETPTPDGLTIRRQMGKNLPELDTEAELVIYRIAQEALTNTVRHARASRLELSLRSSPCGVELRIRDDGRGLGDTPEGAGLRGMRERALLIGAELFLGAGPQGGTEVRLDVPVRNGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIZ2</accession>
    <name>A0A7K2ZIZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001148">
        <property type="protein sequence ID" value="MYW32326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="178"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="31279" checksum="3C11BE09E01D1538" modified="2021-04-07" version="1">MSVSVVSPGRGRTERLSATLLRWSEPSVGGPVVEAPYLLTTAVLDSPAPAGSSASGVHTHDDALLVWPHTGTTTLHTRNTVRRLVPGQAAWMPPGTPHASHPDPGSVACYTYVTRAAIPPHWNAPRSLRMGRALQEMLLHLDANSMPDDRRLRAQRLIIEMLEEDPHAAMEVPVPEDPRIRAMAEDIMRDPESDLSLEEWAALHALSVRTVTRAFGRDVGMPFTRWRSLVRMSAATTLLAQGRPVNLVAHRCGYSTTSAFSAAFRRVTGTSPTAYLREQSALAPVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJI2</accession>
    <name>A0A7K2ZJI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4031 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001196">
        <property type="protein sequence ID" value="MYW32520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510973.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001196.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025109">
        <property type="entry name" value="DUF4031"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13223">
        <property type="entry name" value="DUF4031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4031" evidence="1">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="89" mass="9950" checksum="3DAEF53D646C485D" modified="2021-04-07" version="1">MTLYIDPPTWPGHGRLWSHLVSDESFEELHTFAAAIGCPPRAFERDHYDVPEAYYADAVRAGAREIGSKELVRRLTAAGLRRPKGRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK78</accession>
    <name>A0A7K2ZK78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">GT040_26630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015610729.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001248.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="8490" checksum="66C401CB49F090E5" modified="2021-04-07" version="1">MSAGTKASELRELGDEELLNKLREAKEELFNLRFQAATGQLENHGRLKSVRKDIARIYTLMRERELGIETVESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKC5</accession>
    <name>A0A7K2ZKC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001251">
        <property type="protein sequence ID" value="MYW32778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="21166" checksum="F70669A89101BE2D" modified="2021-04-07" version="1">LFCVGCATGGTGTRDEGPAGTQPVVQVSPQPTISGTTPPTRRVNAVALLKGDPTVSERVREGLRPCAGKAYPVDTSYGSMTGGPSADVVVNVMSCADSVGMGTYVYRAREDGSYENVFMAEVPAVYGTIDRGDLVVTTQVYGSKDPLAYPSGSEVVTYRWADGRFTEHDRVHNDFSRAVDGGGDIEAPTQAEPVEPADPSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKI3</accession>
    <name>A0A7K2ZKI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 6">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfbA</name>
        <name evidence="8" type="ORF">GT040_27210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 6"/>
    <dbReference type="EMBL" id="WWKE01001265">
        <property type="protein sequence ID" value="MYW32862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="32810" checksum="5A9636921440C7A9" modified="2021-04-07" version="1">MKGIILAGGHGTRLHPITRGVSKQLLPVYDKPMIYYPLSVLMLAGVRDILIISTPADLPQFRRLLGDGSDLGVRFSYAEQAEPRGLAEALIIGAGHIGDDPVALALGDNVFHGPRFSQILRSRLPHTEGCLLFGYPVQDPERYGVGEADEHGRLVSIEEKPRRPRSNRAITGLYLYDNDVVAIARDLVPSARGELEITDVNLEYLRRGKAELVDLGRGFAWLDTGTHDSLLAASQYIQTIERRQGVRVACVEEVALRMGFIDPDQCHRLGAALSTSGYGRYVMEVAEAVRSERQKSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKK0</accession>
    <name>A0A7K2ZKK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_27250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001267">
        <property type="protein sequence ID" value="MYW32870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="465" mass="48527" checksum="753F8B195446E9EA" modified="2021-04-07" version="1" fragment="single">MENNTPGPRAGRKEWTALGVLMLPLLLVSMDISVLYFAIPYVSQDLEPSATQQLWILDMYGFVLAGLLITMGALGDRIGRRASVLAGAVLFGAASVLAAYAHSAELLILARALLGLGGAALMPSTLALIRNLFHDAKQRGKAVTLWTAVMTAGVSLGPVVSGLLLEHFWWGSVFLINLPAMVLLLALVPFLVPEFRSAQRERFDLLSSVLSLGAVLLVVYGIKEWARHGYEPLPAVTVGVGLVLGFVFVRRQKHLAHPMIDLGLLGRRTFGGPVFANLLAMFATVGMAVFLTQYLQSVLGLSPFRAALWSLVPAVGAAVAAPVAAVLAQRVDRAYVMGGGFLVSACGFLWMTQVRTDSALRFALVGAALYVGGLVAAMALANELALGAAPPERAGSAAAVLESGQELGGALGMAVLGSIGAAVYSREMADALPAGVPHAEAVRETLGGATAAAARLPDETADAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKK8</accession>
    <name>A0A7K2ZKK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001273">
        <property type="protein sequence ID" value="MYW32894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="10051" checksum="15F3A41CA2E458D5" modified="2021-04-07" version="1" fragment="single">MTEEWQGWREAAETALYGDGGFYRSPVRSPDGPAGHFRTSVHASPLFARAVAGLLARTAQELGLGTVALVDVGAGRGELLTGVLAAAPEGLEVVPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKL3</accession>
    <name>A0A7K2ZKL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001270">
        <property type="protein sequence ID" value="MYW32881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_C39_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="187" mass="20305" checksum="F0CFBD5B72421B14" modified="2021-04-07" version="1">GYGTPGTRLRVEAGRTGSARWLEIGYQVQETGYWCGPAATRIALSARTAPPSQGELAAQLGTTEAGTDHIGQITRVLNARLGGGWYETKEMPDDPPTQGQRDLLWADIVFDIDRDYPLVANIVAPPGNQPPGYPPGQTIYHYFTVFGYDAEDRTVLIADPASFGGNQIYWLSFDQLASLIPPKGYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKL8</accession>
    <name>A0A7K2ZKL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001272">
        <property type="protein sequence ID" value="MYW32885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="10947" checksum="3F5466B879937560" modified="2021-04-07" version="1">LRTHIRGHWTAAALLRAASADGHAALGRPDAGVLEPGAPADLTTIALDSVRTAGPVPRLAAETAVFAASAADVRHTVVAGRHIVRDGRHALIEDVPGALAAAVAALHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKM8</accession>
    <name>A0A7K2ZKM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_27375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001274">
        <property type="protein sequence ID" value="MYW32895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="476" mass="48138" checksum="E54D19B11BD55571" modified="2021-04-07" version="1">MTATAPGPAARPTAPPRSVTAVVGLLVFFEVMSGFLQVGLAPLLPDLADQLAIGSADLNWVVSVQLLAAAVCVPLFGRLGDLYGHRRMLRTALALIAVGTIVVALAPSYEVLLLGRVLQGPIAALLPLEIALVRDRLPVDDARRAIARLVGALTLGAMAGGVVMGLVDSAFGDLRLTLLVPAVLAVVCVPISFVAVPESEGRTGGRVDWAGVALLSTAMIALLGGVGGAEGGSWLTARVFGPLLLGAVLLGAWVVVELRATEPLVDVRALADLRTAPFYAAAFLFGVFFFGSQAPNSSFYAADPEVLGYGFGLSALAISLTLLPASVGSVIGSLGTAALARRIGYRPTLMAAFGLVAVSFLQFALLHTSVVEMAVGSAFLGLGIGLALGAMPTVIVEATEPSRTGIAAALYNNVKTLGGAVAGGVFASVLGAFTSGATGEPGEGGYVAVWLVGAGCAGLAVVMSAISRREESPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKM9</accession>
    <name>A0A7K2ZKM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001280">
        <property type="protein sequence ID" value="MYW32906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="18345" checksum="596C0012449E9AE8" modified="2021-04-07" version="1" fragment="single">MEHQVFVPVPVPALRRTLGDPARVARCVPGIQQDADASASPLAGRLKFRAGGHTITYRGELKLSSAGPDGDRFSVTGEGVEARGAGAVKLALTIGLTETDGGTTLAYSGTASGDGRLAELEEGAALAAAQRLLDRFTQQLVTETLAAQGEDGAGGGGAGNGGSDEAGAEDVSAEGLEGDVEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKU5</accession>
    <name>A0A7K2ZKU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001266">
        <property type="protein sequence ID" value="MYW32869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17352" checksum="279401B54AD8A22F" modified="2021-04-07" version="1">FFVSVLETVVLALVIPWPLVHLILLVVGVYGTVLIVALHAACVTRPHVVGADGSLRLRYGALFDLSVPASLITAARVERRYDGGGLVRVGADGVLDLAVGSRTTVTVELAEPVEFVRPLGRRGSARTLRFHADDPRAAVAALAPRPVTPVTPERTAPSSTPGPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLP4</accession>
    <name>A0A7K2ZLP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ORF">GT040_29445</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="WWKE01001362">
        <property type="protein sequence ID" value="MYW33277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="140"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW33277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="273" mass="30136" checksum="93EBD53E1BD7DA3B" modified="2021-04-07" version="1">MRLDVVTIFPEYLDPLNVSLVGKARARGVLDVHVHDLREWTYDRHNTVDDTPYGGGPGMVMKTEPWGDALDQALADGYESGAHTPVLVVPTPSGRPFTQQLAVELSAKPWLVFTPARYEGIDRRVIDEYATRIPVVEVSIGDYVLAGGEAAVLVITEAVARLLPGVLGNAESHRDDSFAPGAMADLLEGPVYTKPPEWRGRGIPDVLLSGHHGKITRWRRDQAFARTALNRPDLIERCEAGAFDKKDREILSILGFAPEPSGRFWRRPPAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLS8</accession>
    <name>A0A7K2ZLS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretion protein EccC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001371">
        <property type="protein sequence ID" value="MYW33315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="365" mass="41146" checksum="F0DB2B42BDBF35EA" modified="2021-04-07" version="1" fragment="single">MPEGQLTLQEPPVLAESVPDTSAVWTYLPMALMSVSMMLMFLRPGGGNGVFMYLAMGVMALSAGAMLLGQLMRRSSERKQRLKGERRDYLRYLAQTRKRVRTTIAEQQRALAWRHPEPASLRSLARTSRLWERRPADEDFGEVRLAVGEQQLALTLNPVSTRPVEDLEPLCAHALRRFIRAYSTIPEQPLGLYLRSSARILLRPEEAPEGEAAETQAPEQDDVRALVRAMLGQLAVFHAPEELWIALCVSDERRPDWEWVKWLPHVLDPHEEDGAGQARRITADLTELDDLLGAEFAERPGFDPDARPGRDEPYTVIVLDGVNVPEGHRWEGHGYRNALILDVSGALRWRPGRNTLRLTVGADQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM65</accession>
    <name>A0A7K2ZM65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_031124411.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001394.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029745515" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8413" checksum="BEBB9252486E8676" modified="2021-04-07" version="1">MRTRITALAVTAVAAAAMVLGTASTASATGPGFWLRSHHSSLAECQAVGNAGADNALWSRVFICNPYAGKPGVYELWVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMC7</accession>
    <name>A0A7K2ZMC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001392">
        <property type="protein sequence ID" value="MYW33419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="309" mass="33183" checksum="460E1AD23D3B0734" modified="2021-04-07" version="1">MEALRSEIAKAVVGQDAAVTGLVVALLCRGHVLLEGVPGVAKTLLVRALAASLELDTKRVQFTPDLMPSDVTGSLVYDARTAEFSFQPGPVFTNLLLADEINRTPPKTQASLLEAMEERQVTVDGTPRPLPDPFLVAATQNPVEYEGTYPLPEAQLDRFLLKLTVPLPSRQDEINVLTRHADGFNPRDLKAAGIRPVAGPAHLEAARAAVAKTTVSPEIAGYVVDICRATRESPSLALGVSPRGATALLSTARAWAWLTGRDYVTPDDVKALALPTLRHRIHLRPEAEMEGVTPDSVITSVLAHVPVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMQ2</accession>
    <name>A0A7K2ZMQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Murein biosynthesis integral membrane protein MurJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murJ</name>
        <name evidence="10" type="ORF">GT040_31020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001435">
        <property type="protein sequence ID" value="MYW33578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW33578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="720" mass="75788" checksum="66862125BCA8FD14" modified="2021-04-07" version="1">MNAPYDGDRGQGAGGAGSPSGPPVPPGPGQDGQVPPDPYLQHAYEDDPYRAQDLAAQDPVGEALYDRASHPPPPPGTYQEPQALYQQPPAAPHAPDPRIWAQTPPPEPSGPSRHLPYGDRPATTQFVGVDDLVTQASDDRREPDAFAHLFRDQEGAGKVPGPPEPEPAPAPVPPKSGGGKFSGVLKSSALMAAGTLVSRLTGFIRSLVITAALGAALLGDSFTIAYTLPTMIYILTVGGGLNSVFVPQLVRAMKDDEDGGEAFANRLLTLVMVALGLIVGIAVLVAPVLIQLMSNTIADDVAANSVAVTFARYCLPTIFFMGVHVVMGQILNARGRFGAMMWTPVLNNIVMIITFGLFIWVYGTSAESRMGVDTIPPEGIRLLGIGTLLGLVVQALAMIPYLREAGFRFRPRFDWKGHGLGKTVKLAKWTVLFVLANQAGVLVVTQLATAAGKLSGKDGTGFLAYSNAQLIWGMPQAIITVSVMAALLPRISRAAHDNDPGAVRDDISQGLRNSAVAIVPVAFTFLALGLPMCTLLYASSGAEAARSMGFILMAFALGLIPYSVQYVVLRGFYAYEDTRTPFYNTVIVAAVNAAASALCYVVLPARWAVVGMAFSYGLAYAVGVGVAWRRLRTRLGGDLDGAHIVRTYARLCMAAVPAAVIGGGIGFAILELLGTGALGSLAALICGGTLLMGVFFVAAKKMRIEEVNGLVGMVRGRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMS1</accession>
    <name>A0A7K2ZMS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">GT040_31345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001437">
        <property type="protein sequence ID" value="MYW33641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="272"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="514" mass="55796" checksum="19B5941EC869A061" modified="2021-04-07" version="1">MTDAHTTGTHGTGPFIAAIDQGTTSSRCIVFDKDGRIVSVDQKEHEQIFPKPGWVEHDATEIWENVQEVVAGAIVKAGITSADVKAIGITNQRETTLLWDKNTGEPVHNALVWQDTRTDALCKELGRNVGQDRFRRETGLPLASYFAGPKVRWLLDNVEGLRERAEAGDILFGTMDSWVIWNLTGGTDGGVHVTDVTNASRTLLMNLHRMEWDEKILSSIGIPAAVLPEIRSSAEVYGHAKGGILDGVPVASALGDQQAALFGQTCFAEGEAKSTYGTGTFMLMNTGSTPVNSYNGLLTTVGYQIGDKPPVYALEGSIAVTGSLVQWMRDQMGLIKSAAEIETLASSVEDNGGAYFVPAFSGLFAPYWRPDARGVITGLTRYVTKAHIARAVLEATAWQTREISDAMTKDSGVELTALKVDGGMTSNNLLMQTLADFLDAPVVRPMVAETTCLGAAYAAGLAVGFWPDTDALRANWRRAAEWTPRMDADTRAREYKSWLKAVERTMGWVEDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN29</accession>
    <name>A0A7K2ZN29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF839 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001441">
        <property type="protein sequence ID" value="MYW33669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="596" mass="65220" checksum="121C6ADDE86FBFA2" modified="2021-04-07" version="1">PPRKPAPSGARGLRFPPVAPNKNDKVTVPDGYNQNVVIRWGEPILRGAPAFNPEKQTAKAQAGQFGYNNDFLSLLPLRGERGRQVLVANHEYTDEILMFRGYDPANPTREQVEIAWAAHGLSVVVVQEESRTGKLGAVSRHPLNRRLTATSEFRVTGPAAGSDLLRTSADRTGSRVLGTLNNCAGGTTPWGTTLHGEENFNQYFANGTTAEHKRYGIGTGATERKWERFDRRFDLAKEPNEANRFGWVVELDPYDPDSTPRKRTALGRFKHEAAEPRLTSDGRPVVYMGDDERFDYLYKFVSSKRMKKGTSRAAREHNLTLLDEGTLYVAKLTGDSPASEIDGSGRLPDDGEFDGSGVWIPLATGTTSHVPGMTADEVYVYTRLAGDKVGATKMDRPEDVEPSPRTGRVYVALTNNTDRGKEGKAPADEANPRNLNKHGQILELAENWDDPTSDGFAWRLFLVAGDPNDPSTYFAGFPKDRVSPISCPDNVAFDDHGNLWISTDGNQLGSHDGLFGVATHGDRRGELKQFLTVPAGAETCGPVIQDRRVLVAVQHPGEVDGASVEKPASTWPDGPGKIVRPSVVAVWRKDGRDIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN57</accession>
    <name>A0A7K2ZN57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol system anti-sigma-R factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510074.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001443.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11865" checksum="DF438770A24A3C3B" modified="2021-04-07" version="1">MSCGEPHETDCSEVLDHLYEFLDREMPEGDCTKFEVHFEECSPCLEKYGLEQAVKKLVKRCCGQDEVPTDLRSKVMGRIDLIRAGEAVPEQDITVGGTDQAATARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN59</accession>
    <name>A0A7K2ZN59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001461">
        <property type="protein sequence ID" value="MYW33777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14233" checksum="F7180221885F8D96" modified="2021-04-07" version="1" fragment="single">MSATVLTASALLLDMDGTLVNSDAVVERCWRRWALKHGLDPEAALKVVHGRQGYATMAVLLPDRPVEENYADNRVMLAEETADVDGVVPIGGAPAFMAAIADLPHALVTSADSALAAARMGAAALPMPAVRVTAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN66</accession>
    <name>A0A7K2ZN66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_32185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001481">
        <property type="protein sequence ID" value="MYW33803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="76"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="246" mass="26104" checksum="3A1F5C66F2E19A46" modified="2021-04-07" version="1">MAGLELEGSNPDVSVLYGINGLAKAAPTWLDRVMEFVGEYGTMFGLVLVGLWCWWSMRKRGSAEDSVSTVAALVWAPLAAALAVVINIPIRGFVERPRPFNDHEGLEVLIHGKTDYSFVSDHSTLAMALAVGIFVANRKFGFVALGLAVFAGVSRIYMGVHYPTDVIGGFALGTAVALLLAPLAMALLTPLMAAVSRSDRVGWIVRSKKADAADAAYADERGDTHGIPEPRPGSGRGHPGEKDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNB0</accession>
    <name>A0A7K2ZNB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001462">
        <property type="protein sequence ID" value="MYW33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="454" mass="46743" checksum="C0D12F7D7260E2C0" modified="2021-04-07" version="1" fragment="single">PAGRSAIDDARALVERAEERLWALGAAPETLADGRTPSAPAPGDTDAPREPAPAVFLETEHRTWLLDQVTEADLPPTPVPPDDGETVTGADLRAAGVTLSPGTHAEMALLGDRLPANRLSAPDLTRVRLARTDDTTGVTAAVAAEVTRRLWARTYAALRATAPGARSDEETARAWAAAVVLVLPPQPHPVLADARFAGDGFRDAVRRIAGHLLTAEPGAEGVRESAAKLADTLREGLGLAPRWSVPPEGPTTGRAAPGTPALQSGQGGELPVLDMPDADPGQGHLPDPATDPATDLGMDLGMAMDLDGSGLPDAFLSVPDGLDLAVWGALGDMDTWGALGDLGDLGDLGDLGDLGDLGELPDLGFTFDPPAPVPVGPGEGDGQPVYAVPAAPPARPLTTLPALTLVPFAPHSTGTADSADGTTERLAHQVARTALRNRRNRVPLPRIDIAGYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNF9</accession>
    <name>A0A7K2ZNF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="18166" checksum="B86329ABD75B554D" modified="2021-04-07" version="1">MTTTEIKPNDRTATPAPTTRLNFAKAAPRVFRAVIGLDVAAREGLDPTLVELVQIRSSHLNHCAYCLHMHTTDARKAGESEKRLHMVAVWQEAPHFFTEREQAALALTDAVTRVADAGVPDAVYNQAAAHFDEQELGQLLALILTINTWNRIALATAKRAGTDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNS5</accession>
    <name>A0A7K2ZNS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001530">
        <property type="protein sequence ID" value="MYW34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="43"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="130" mass="13557" checksum="896A4F815D408237" modified="2021-04-07" version="1" fragment="single">ATAAFPPPAEGVLVTDHRLPGPDPLRVRVYRPREAAPLPLPCLVWIHGGGLVLGTPETDDARVSRYVLEAGCAVVSVDYRLAPEHPFPVPAEDCYRALRWTAEQAGALGVDAERIAVGGISAGGGLAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNW7</accession>
    <name>A0A7K2ZNW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001537">
        <property type="protein sequence ID" value="MYW34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16044" checksum="71A1A1E3074142CF" modified="2021-04-07" version="1" fragment="single">MADRETRPTTVWSRPERGARGPAPERSRYEITAAALALADAEGLAAVSMRAVAQRLGTGPASLYRYVGSRDELLDLMADAVAGELDLSAAPSGDWLGDLVGLALQSKAAHTRHPWLPELNDRRGEALGPHAIDYLDHALAVLAPAPGTSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNZ1</accession>
    <name>A0A7K2ZNZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF3817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_33555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001540">
        <property type="protein sequence ID" value="MYW34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="12030" checksum="BB2302C72EC9519B" modified="2021-04-07" version="1">MKQNVLTRYRVMAYVTAIWLLVFTVAIIAKYAFDTGDTMVISQIHGVLFIVYVIFAFDLGSKAKWPFGKLLWVLAAGCIPFASFFVEPKVSREAQALITKPAAEPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP37</accession>
    <name>A0A7K2ZP37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001547">
        <property type="protein sequence ID" value="MYW34131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="257" mass="27394" checksum="89B4EB3773568EBF" modified="2021-04-07" version="1" fragment="single">MDPVIVVGAGPVGLTLSLALAAQGVPCVLLDEGPGTEEVRLARTVVLREDTADLVGRLGAVHLEKDGLRWSGWRSMRRKQLVRDVPLGPGHDGSRDAGTSGDVRDVGDFGDADVRSGPSLSAPLHIPQHALASALRAAVAAAPLVELVPLSRVDTLEQDRDGVTVHTKGPGTTWWRGSYLVGCDGARSTVRKLLDIRFPGRTAVERHAVAALRAELPWPGEAVLHRQPPWRGGGAEVSARPLPDGVWRLDWLLPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPQ0</accession>
    <name>A0A7K2ZPQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnp</name>
        <name evidence="9" type="ORF">GT040_34870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001592">
        <property type="protein sequence ID" value="MYW34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014069">
        <property type="entry name" value="GPSI/PNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02696">
        <property type="entry name" value="pppGpp_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="651"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="737" mass="79537" checksum="826732ECBBAD832F" modified="2021-04-07" version="1">MENETHYAEAVIDNGTFGTRTIRFETGRLAKQAAGSAVAYLDDDTMVLSATTASKRPKENLDFFPLTVDVEERQYAAGKIPGSFFRREGRPSEDAILTCRLIDRPLRPSFKKGLRNEIQIVETIMALNPDHLYDVVAINAASCSTILAGLPFSGPIGATRVALIKGQWVAFPTHTELEDAVFDMVVAGRVLEDGDVAIMMVEAEATEKTIQLVKDGAEAPTEEIVAAGLDAAKPFIKALCKAQSDLASKAAKPVGEFPVFLDYQDDVFEALAKAVTSELTQALTIAGKQDREAELDRVKEIAAEKLLPAFEGREKEISAAYRSLTKKLVRERVIKDKVRIDGRGVTDIRTLAAEVEAIPRVHGSALFERGETQILGVTTLNMLRMEQQLDTLSPVTRKRYMHNYNFPPYSVGETGRVGSPKRREIGHGALAERAIVPVLPSREEFPYAIRQVSEALGSNGSTSMGSVCASTMSLLNAGVPLKAAVAGIAMGLISQEIDGKTHYVALTDILGAEDAFGDMDFKVAGTKQFVTALQLDTKLDGIPASVLAAALKQARDARLHILDVMNEAIDVPDEMSPNAPRIITVKIPVDKIGEVIGPKGKMINQIQEDTGADITIEDDGTIYIGAQQGSQAEAARATINAIANPTMPEVGERYLGTVVKTTTFGAFVSLMPGKDGLLHISQIRKLAGGKRVENVEDVLGVGAKVQVEIAEIDSRGKLSLIPVIEGEEDETKDDTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPT5</accession>
    <name>A0A7K2ZPT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001595">
        <property type="protein sequence ID" value="MYW34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="92"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="20851" checksum="474CC512505426A2" modified="2021-04-07" version="1">MALRHAVLAALLDEELSGYQLAKAFGMGVANFWHALPQQLYAELAKLEKEGLVAGREVVQDARPNKRLFRVTDDGLAELERFAAVAAKPSFIRDDLLVKVQAADHLDAVELIARLTERAEFAEVRAAQFEVLLKGMRGGRPEEEFLRYGERIGPYLTCRRGLAFERANRDWCREVIDVLRARSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPU9</accession>
    <name>A0A7K2ZPU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001604">
        <property type="protein sequence ID" value="MYW34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="304" mass="33564" checksum="01E15EC55775CCE5" modified="2021-04-07" version="1">MSNGSPGAPVVHGFPHLDTVRSAITALYRRLSPDGVHSYGTSLVPADAAFSDADDLHLGAQRVARALVQHLHLPDARMIVGFRTMEHAASVELTAGPEYFIELNDRFRTHRRDIGAALAHEITHVLLHRLGLEFPGTRDNEILTDTVTAYLGAGWLLLDAFREDAMSRQKLGYLTPEEFGYVLAERALVFDEDPSPWFTSPQAYTAYTKGRAQALHDLRRPPLTAAGWAGRRRYAKDRRYAQDHPGTAPGTGTDPGVPYAFEPGGEGLRVSFPCPTCHQRIQLPVRGRTVARCGLCRTRLECDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPV4</accession>
    <name>A0A7K2ZPV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_35250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001609">
        <property type="protein sequence ID" value="MYW34396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="22759" checksum="9590ED428AA91051" modified="2021-04-07" version="1" fragment="single">MRALHVITGLGVGGAEQQLRLLLRHLPVECDVVTLTNPGPVADGLRADGVRVTHLGMRGNRDVSAVGRLTRLIRDGRYDLVHTHLYRACVYGRIAARLAGVRAAVATEHSLGRAEIEGRPLTRGIRALYLSTERLGAATVAVSSTVAGRLRDWGVPAERIRLVPNGIDADRYRFDPDRRLAVRAALGVPDDAFVVGGVGRLVPGKRFDVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ48</accession>
    <name>A0A7K2ZQ48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gap</name>
        <name evidence="11" type="ORF">GT040_35780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001628">
        <property type="protein sequence ID" value="MYW34494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015607849.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001628.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="336" mass="36170" checksum="EB1B76EE7BF1D5EA" modified="2021-04-07" version="1">MTIRVGINGFGRIGRNYFRALLEQGADIEIVAVNDLGDTATTAHLLKYDTILGRLKAEVSHTADTITVDGHTIKVLSERNPADIPWGELGVDIVIESTGIFTKKADAEKHIAGGAKKVLISAPAKDEDITIVMGVNQDKYDAANHHVISNASCTTNCVAPMAKVLDENFGIVKGLMTTVHAYTNDQRILDFPHSDLRRARAAAENIIPTTTGAAKATALVLPQLKGKLDGIAMRVPVPTGSATDLVVTLDREVTKDEVNAAFKKASDDGDLKGFLTYTEDPIVSSDIVGDPSSCTFDSSLTMVQEGNTVKILGWYDNEWGYSNRLVDLTVFVGEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQV0</accession>
    <name>A0A7K2ZQV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-inositol-3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.250</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="7">GlcNAc-Ins-P N-acetylglucosaminyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">mshA</name>
        <name evidence="11" type="ORF">GT040_36915</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:26188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:58892"/>
            <dbReference type="EC" id="2.4.1.250"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase group 1 family. MshA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01695">
        <property type="entry name" value="MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017814">
        <property type="entry name" value="Mycothiol_biosynthesis_MshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03449">
        <property type="entry name" value="mycothiol_MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="10">
        <location>
            <begin position="51"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="9">
        <location>
            <begin position="243"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="7">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="1D-inositol 3-phosphate binding" evidence="7">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="450" mass="47780" checksum="48763FACDED9B970" modified="2021-04-07" version="1">MSQYVSRLGSTRTGPRIRFPGSFPGSSRKPRRIAMLSVHTSPLHQPGTGDAGGMNVYIVELAKRLAAINIEVEIFTRATTGSLPPEVELAPGVLVRHVDAGPYEGLAKEDLPAQLCAFTHGVMQAWAGQRPGYYDLVHSHYWLSGQVGWLAAQRWGVPLVHAMHTMAKVKNAALAEGDTPEPAARVIGETQIVHASDRLIANTAEEADELVRFYDADPSSVAVVHPGVNLDRFRPADGRAAARARLGLPQDALIPLFAGRIQPLKAPDVLLRAVAVLLDRDPSLRSRIVVPVVGGPSGSGLAKPEGLQKLAARLGIADVVRFHPPVGQDRLADWFRAASVLVMPSYSESFGLVAIEAQAAGTPVVAAAVGGLPVAVRDGVSGFLVPGHDPEAYARALERFAQAPELVERMGAAAAAHAQSFGWDTAASGTADVYTAALADHRRRARTHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR40</accession>
    <name>A0A7K2ZR40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001685">
        <property type="protein sequence ID" value="MYW34767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023100">
        <property type="entry name" value="D-aminoacylase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="539" mass="57668" checksum="D32738C1392FB21D" modified="2021-04-07" version="1">MDLVLRDALVVDGTGEPSYRADVAVDGGRIAEIHREGSPGPRPTATRTVDADGLALAPGFIDMHAHSDLALLRDPDHSAKAAQGVTLEVLGQDGLSYAPVDDRTLAEVRRSITGWNGDGSDIDFDWRTVGGYLDRLDRNFGGEGIAVNAAYLIPQGTVRMYAVGWDDRPATDAELARMKELVDQGMREGAVGMSSGLTYTPGMYADDAELTELCRVVARHGGYYCPHHRSYGAGALEAYEEMVQLTQSAGCALHLAHATMNFGVNKGKAPDLLALLDGALAAGSDISLDTYPYTPGCTTLVAMLPSWAGEGGPESVLTRLADPESAEKIRHHLEVLGSDGCHGVPIEWDTIEISGVSAPHLAAYVGRTVAESAALRGEEPWVTARRLLTEDRLGTTILQHVGHEENVQQIMRHPVHTGGSDGILQGDKPHPRAYGTFPQYLGRYARELGILSLEECVAHLTSRPAARLRLADRGLVREGYRADLVLFDPETVAAGSTFEEPRTLPVGIPHVLIGGRFVIEDGRRTSVLAGRAVRGAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRW7</accession>
    <name>A0A7K2ZRW7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">ligA</name>
        <name evidence="13" type="ORF">GT040_39100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="WWKE01001777">
        <property type="protein sequence ID" value="MYW35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="615"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="46"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW35130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="765" mass="79895" checksum="8BB4005923CE781D" modified="2021-04-07" version="1">MVGGRMVTMTNSAAVLADAAAYAAAVEEASQAAAAYYATGESTLDDDAYDRLARGIAAYEVDHPDEIHESSPTGKVAGGAAVGDVPHTVPMLSLDNVFSAEQFATWTASLERRIGRPVAAWSVEPKLDGLAVAARYREGRLERLITRGDGSAGEDVSHAAPAVTGLPERLSAPVTIEVRGEILMTNEQFDQGNATRTEHGGAPFANPRNGAAGTLRAKDRAYRVETTFFAYGALPLAGSGELAETLTELPHSELLAYVAGLGVHTAAATAVAPVRVTTVEEVQARVAEIAALRAELPFGIDGIVIKADLAADRREAGSGSRAPRWAIAHKLPAVEKITRLLSVEWNVGRTGIIAPRAVLEPVEIDGSTVGYATLHNPADITRRDLRLGDRVMVYKAGDIIPRIEAPVAHLRTGEETPIEFPASCPQCGSGIDTSEQRWRCTRGRDCRLVASVSYAAGRDQLDIEGLGTTRVVQLVDAGLVTDFADLFTLEREQLLALDRMGETSTDNLLAAIGTARSRPLSRVFCALGVRGTGRSMSRRIARYFATMDHIVAADTESLQRVDGIGKEKAAAVVAELVELAPLIEKLVRAGVTMTEPGATPPPEPGAEEEGGGGTGAELPLAGMKVVVTGAMSGALEKLSRNQMNELIERAGGKSSSSVSARTSLLVAGEKAGSKRTKAEELGIRIAAPEEFAELIAGFLAGETEEAPEAGAAVEIVAVTGGETAAVAVLAVEGKPAAAGPAAEAADAVEPVEVAEAVEVVEAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSA1</accession>
    <name>A0A7K2ZSA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VII secretion protein EccB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001808">
        <property type="protein sequence ID" value="MYW35236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="14833" checksum="27AB84B478CF1783" modified="2021-04-07" version="1" fragment="single">MQSKRDQVQAHGFMMGRLSSGLLTADPDAPESPLGRTTRGVVFGILVTVLIGAGTTVYGLLRPGGNETWRKGENLVVNRETGARYLWTGTDGVLHPVRNYTSARLIGGAQLKAVDVSTASLRDVPVGSPAGIPGAPDTLPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSC6</accession>
    <name>A0A7K2ZSC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001831">
        <property type="protein sequence ID" value="MYW35294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029712458" evidence="1">
        <location>
            <begin position="33"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="437" mass="46731" checksum="A14222594F5A9F57" modified="2021-04-07" version="1">MRQKAVRLALVGGVVFLALLLLLATCGGNPESQGNKDAVPVKRVMPSAGPVTRLTVPPQYATDRGWEIIGSSPEVAVSHATGRLAYLERLNGNRYRLRTVDTATGRLGWQGQAWRPPDPLHYPRLATVTAGDRQYFVTWSYGKVGDGLTPASTFVSLDVYDVTDGARQRVEVPWSGAPDVDTNGPEIVISDGKANSTLVDPVTGTVSELSADELKYPKGCPACKQLTEVYGQTAAGLLVGGAREFWVRGGWFSRNVAPRGADPGSGVVTSVAGERVLAKWALGKKAKRVATHELWTVHDTLTGKPLVSVECHRPAIKPGRYPQAVLSPSGDHLIAGNLAFDLAGGRGHCFEEEDGSSHLALASVTDDGIAYGAENARDASEALSGGGLPVAVDFANWTTERLSRNARLPGLETTGVGVFRWTDRQERTRLIGYPRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSC7</accession>
    <name>A0A7K2ZSC7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosyl isomerase A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8">5.3.1.16</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="8">PRAI</shortName>
            <ecNumber evidence="8">5.3.1.24</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">priA</name>
        <name evidence="8" type="synonym">hisA</name>
        <name evidence="10" type="ORF">GT040_29950</name>
        <name evidence="11" type="ORF">GT040_39480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in both the histidine and tryptophan biosynthetic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8"/>
    <dbReference type="EC" id="5.3.1.24" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001386">
        <property type="protein sequence ID" value="MYW33375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001789">
        <property type="protein sequence ID" value="MYW35198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010188">
        <property type="entry name" value="HisA/PriA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01919">
        <property type="entry name" value="hisA-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW33375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW35198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="241" mass="25072" checksum="11CC759EB079F006" modified="2021-04-07" version="1">MPKLELLPAVDVRDGQAVRLVHGESGSETSYGSPLEAALAWQSAGAEWLHLVDLDAAFGTGDNRDLIAEVTGAMDIKVELSGGIRDDASLAAALATGCRRVNLGTAALETPEWVAKVIAEHGDKIAVGLDVRGTTLRGRGWTRDGGDLYETLARLDAEGCARYVVTDIAKDGTLQGPNLGLLRDVCAVTDRPVVASGGVSSLADLRAISLLVPEGVEGAIVGKALYAKEFTLEEALKAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSH1</accession>
    <name>A0A7K2ZSH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_40005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001831">
        <property type="protein sequence ID" value="MYW35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="13853" checksum="150FA428E4B95950" modified="2021-04-07" version="1" fragment="single">MNVTLPTAQSLRAALAGLLDGLPPKQAAQAVDRLIASYRGETPTGAPILRDRSDVVAYAAYRMPATFEAVRSALDALDEAAPDWAPATHTDVGGGTGAASWAVAGAWEGAATTVLDWAEPALALGRELAEASGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSV2</accession>
    <name>A0A7K2ZSV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sheath polysaccharide-degrading enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001830">
        <property type="protein sequence ID" value="MYW35289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029584300" evidence="1">
        <location>
            <begin position="30"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="93"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="319" mass="32862" checksum="E79501CE16143DF4" modified="2021-04-07" version="1">MRPRTPLTALLAAALASGGLVLTAAPANAAAVIDVSTAAQLKSALTTVSPGDTIRLADGTYTGNFKATRPGTSGARIILTGSSRAVLTAGGGYGLHLNGASYWTVHGVTIKGGQKGIMADTANGVVIDSVTVHDLDMEGVHFRKSSRDGVLKNSRIYDTGQNGRGMGEGVYVGTANDLSDRSDNAQILNNTIGPDVRGENVDIKEGTTGARIIGNTFDGNGLTGANYDDSWVDVKGNDVLVEGNRGSRTTNNGYETHTQQSGWGCGTVFRNNTSNLSGATGDRQLAVNVTNNSATCRTTVYASNTVTGGRGLTNVPVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5U0</accession>
    <name>A0A7K2Z5U0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_00080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="101"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW27709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="166" mass="18796" checksum="BAFBC17D28C3D010" modified="2021-04-07" version="1">MTVEEFEEFYAQAVARLTGQLYVMTGDLQEAQDVVQEAFVKAWVRRGRLERDGQPEAWIRTVAWRLAVSRWRFRRRSADAWGRGSGAAEHVAPPDPDHVVLVDALRELPAQQRRTLTLHYLCDLTVEQIAGETGLSASTIKTHLVRGRAALAHRLQDPRTEEAPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Y9</accession>
    <name>A0A7K2Z5Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_00320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000008">
        <property type="protein sequence ID" value="MYW27754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="261"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="507" mass="54090" checksum="9D4E3B3DBD3DE356" modified="2021-04-07" version="1">MAPEPPLLTMSGITKSFPGVRALDGVDLEVQAGEVHCLLGQNGAGKSTLIKVLAGAHQPDDGEITWRGEPARLKSPIAAMRLGIATIYQELDLVEGLSVAENVFLGHEPTSAGFIVRTGEGRSAAKALLARLGHPEIDPARPVGSLSAAQQQIVSMARALSHDVRLIVMDEPSAALDPDEVDNLFRIVDSLTADGVAVVYISHRLEEIRRIGDRVTVLKDGRAVAVGLPAADTPTRDIVAMMTGRDVEYVFPPRPDDPHANTTEPVLRVQGLSRKGEFAPVDLELRPGEIVGLAGLVGSGRSEILETIYGARKASTGTVTVGGKQLRPGSVRAAVAAGIGLAPEERKAQALLMTESVTRNVSVSSLSRFARVGWIDRGGERRSARQATRELSLRPDNPDTPIRTLSGGNQQKAVLARWLLRGCRVLLLDEPTRGVDVGARAELYAVIRRLADEGLAVLLVSSEVPEVLGLADRVLVLREGQVVHTAPAQELDEHRVLDLVMEGSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Z9</accession>
    <name>A0A7K2Z5Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000010">
        <property type="protein sequence ID" value="MYW27767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22303" checksum="87118240B7BB6045" modified="2021-04-07" version="1" fragment="single">MGPVSRTASPARRRRSRLLRYAAGFTVLAALGGYLAVQYDSSTTESAPRCVVRAPEGDHTYEMSLHQAANAATISAVGTTRGMPERAVTIAIATAIQESTLRNIDYGDRDSVGLFQQRPSQGWGTVAEIMDPVYSAGEFYDHLAKVPGYSRLPLTVAAQRVQRSGFPQAYAKHEPDAALLAAALTGREPASLNCTPPKRAAGSPGDAAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z646</accession>
    <name>A0A7K2Z646_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name evidence="3" type="ORF">GT040_00665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000019">
        <property type="protein sequence ID" value="MYW27817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="31681" checksum="39E8E9AB067AFDF7" modified="2021-04-07" version="1">MSTNHPDPEATGAETPHLDFAGTTPYEDYVQADVLTHLQHLRSDDPGEMVFLVTTQVMELWFTVIVHEWETATRALREDRIPVARDALKRSLRELEALNESWRPLAGLTPAQFNSYRGSLGEGSGFQSAMYRRMEFLLGDKSASMLVPHRGAPRVYAELEKALGEPSLYDETLALLARRGYAIPEAVTTRDLTQRYEPSPEVEAVWAEIYSAADQNDELVRLGELLTDVGELVWRWRNDHLVATRRAMGSKTGTGGSAGVAWLEKRATKNVFPELWTARSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6I6</accession>
    <name>A0A7K2Z6I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000060">
        <property type="protein sequence ID" value="MYW27959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029465926" evidence="1">
        <location>
            <begin position="25"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="47"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="416" mass="43218" checksum="0CC44E7D5F372547" modified="2021-04-07" version="1">MKLRALTAVVAALTVTLVGCSGKATEGKGDGQDEGGIRTGPGVTSSTISLGVLTDMTGVYASLGKSVTQAQQLWAKQINAKGGICDRKIELTVRDHGYDPQKAIAGYTELEPKVLGFAQFIGSPFVAAVEQRIDGKDKGLVLPQAWSANLLGSPYIRVVGATYDVETINLIDHLLGEKRIAKGDKIGHVYFEGDYGENALTGSKHAAKEAGLTVVEQKIKPTDNDMTAQVAALKQAGVKAVVVSAGPRQAASLVGVAAATGFNVPVVGNNSAYAPQLLKTQAGPALLKDYYIASSTLPIGDPGDGPSLLAKEYASQYPNDVLDNGVVAGWTAASIFGEALDKACDNKDLTREGVDKALLTIKGYGTEFGVTHDFSDPAVPSTRESVIMKPDASVPGGLKVISPASVSDAAKSFTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6J4</accession>
    <name>A0A7K2Z6J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000057">
        <property type="protein sequence ID" value="MYW27923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="228" mass="24345" checksum="5FF04986DAB30FB2" modified="2021-04-07" version="1">MIRNVLGSLVALAGAASAVLSPFRDWYDGRAGQDYRVRDLFEGITATESGVLVSILLPFLFAALLVIAGVVLRSRIAVALAGLVVLGFTILWMVRQGQAAGSLTVGGDGAGLQVGVVNALAGGVLMLIGALLMRGRRRGVTRARREREREPVEPYGAPPADQVDTWPPTQEPGMSTNTSPWPEPEVDPYTGPDPHDPRTRSYPQAPPPPDRPGDPRDPVHPPQRPPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Z3</accession>
    <name>A0A7K2Z6Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000102">
        <property type="protein sequence ID" value="MYW28116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029525378" evidence="2">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="224" mass="23074" checksum="7CEC58B6890B8EB5" modified="2021-04-07" version="1">MGASVLALAVIGAGVWFFTSGSASNSDVADSTKGYKLTPAASVDDYAKDPAKPDRSGPLTGKSKADAEAAGVKDPQQAGAQYQSGSKDNPLTQKLLLLQGYWGEVQDPAKVINNSFSDAEKKMSESSNGAKVSLVGSPKDVKPAGFDGALMRCQDLKTVNDKADGTLAKGPKEVITPVCIWADYSTVGMVVAVDVGGALTGKGIAQDDVAALAAKLYNTSRTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z744</accession>
    <name>A0A7K2Z744_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000103">
        <property type="protein sequence ID" value="MYW28138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="487" mass="54831" checksum="638200552FE6E79D" modified="2021-04-07" version="1">MGAEAYRFKEDQLDRARWWIYITLPINVGETFDLRLDVLCLSASYERVEPRILTLVAERLHDRDARVDPDFAILLTSDPAAADLVKRRRGQLAILTINSDELISGSGVGLRDRIAEIMVTHDHYDLTRPITEPAAFYGRQAEVAELDFALDRGQSVGIFGLRKAGKTSLLNFVARQHERVGKPVIWLDISVLQTAEAFQLDLLEKCHKIIRQLGQKIPRLMTLTRDGNPNPTVQTSGYWIRDLNVLLDALPGRLELFIDEIDQAWPSRSNLGVEQAAAVMRCLIQLRGVVQSREAEGKHGIGIVSAGVDPAIFERPLLDGRDNLLYKFARLAFLSPMKRSEMGEMVRSLGKRMALRYSDHRAIDFLFEEFGGHPLLTRKACSVAARKRPRGEIPWHVPLSALEEASKMRGPNTPQSEVADVLASFTEWFGDEAAMLPLLWSDDPQESAEAKEWARNEPDMAAHLVSYGITDENWAPRIHAMRALVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z773</accession>
    <name>A0A7K2Z773_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_02660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000113">
        <property type="protein sequence ID" value="MYW28200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="247" mass="26358" checksum="2199467858CE81BD" modified="2021-04-07" version="1">MSSTTSTRTRILQVAAQLVGDSPDGDISTRAVCEAAQVGAPALYRHFGDKEGLLSAVVDHGFEQYLATKRERGASADPVEDLRRGWDSHVEFAVRNPNLYRLMNSPAMRTPPAAALESHRILTRDLERAAAQGRIRVAPELAAQMVMSATVGVALMLVARPATFDDPGLSRRVRDAVHASILTPDSDPDPDSDPGPGTGAREEAEVPSAAARLSALLRRAQGSGLSTAEAALMKEWLDRVANTGPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7A2</accession>
    <name>A0A7K2Z7A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000112">
        <property type="protein sequence ID" value="MYW28195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="295" mass="31408" checksum="7EF10607DC99CE3C" modified="2021-04-07" version="1" fragment="single">MIGAGTGAMAAAARLAVAGNKVTVYERSASCGGSLGRHEHEGFVFDTGPGLLHLPAVQRDLFVKTGREPLEQSVTLTQVDPASRHLFADGTAVSLPNASRAGVAAALDAALGAGAGERWTGFLERARDAWDRSRRPLLEEPLRADHQVLGRDPYPALKQRRLLRTRQAATVAEIGAWELADARLAALLDGYALSYGLDPRTAPSSAALLPYMEQSFGSWYVMGGMRELARAVYERCVARRVEFVFGAEVVRVVEKDGRAAGVELAGGQVAEADRVVLGVRPRPGLVPGGQVWGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7G6</accession>
    <name>A0A7K2Z7G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="509" mass="56426" checksum="1ED23E16B10EDC87" modified="2021-04-07" version="1">MPIDASKVESPGWWLQRLGKKLLDERDDRTGDDNEVTPGLTSLRHAAEGKPKLPHVPGVDPREIKEWMRDARTNWLSLVIDSPGERLGVEGFRFDDAGEGRDSADEARVSDSEANRIWQENSMDADSALVHYGAMSQRRAFVLVERGDDGRPVLTHETPTQVSVEHEQGNRRKLAAGLKLWRDDWTGDTRATLWTPTKVHEFTTKTSDPTFSGRAAELRGWDALALPTHADGVRTNDLGVVPLVPFINRRNRRPEGFAEHEDVLSIQNRINLSLINLIAAMKYGAFRQRWAAGLEVDEDPVTGKPLQPFQLDIRKLWTTDNPDVKFGEFAATDLMPYVRAVEAAVQDLAAISRTPPHYLIGAVVNVSGDALKAAETGLISKVRDRQRGFGESWENVMRLAFRVIGDEARATAWGAETIWRDPESRTISELADAAVKKASAGVPWRQRMEDMGYTPAQIARMEVDRAADALNAAPAEDPQPASLQAKRDSKNDERAVIGRGDADDAPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7K4</accession>
    <name>A0A7K2Z7K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="13369" checksum="D1BA0549AB465691" modified="2021-04-07" version="1">MLLFQTAELRALLGTPISDERAQLAHDLAEDAIVGEVGERISAPPQRGIKTVALSVAARILTNPQGVRSEQAGGMLVSYTDAQTGVVLSDDELRRLRRAVGMSAGAGMLSIAPEEASYPTSVWRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z948</accession>
    <name>A0A7K2Z948_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000274">
        <property type="protein sequence ID" value="MYW28869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="21253" checksum="8781A05C3034B463" modified="2021-04-07" version="1">MGGMTAPTPFGPREFQLVLLRRMADHQPGPVEEARQELSASLADMREANRRWQAMVRAPRGRGSLRRYRSVLGEPELTLKRRVGDLECEALLWPVPLWPDLRFEVMAAPGGAVWNEWLVRAPGAAGPELTSVPSLRPWSCTVDEVARAFPPARPMEGSAPTRWALAVTDPDSGEPYVAEFTWGLFQRLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z971</accession>
    <name>A0A7K2Z971_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000277">
        <property type="protein sequence ID" value="MYW28872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="717" mass="77754" checksum="54D7FE7B04CF8D53" modified="2021-04-07" version="1">MTDHERRQDTEAAPLRRIDRRTNGEIRPTERLAMNRTGSFDWDLDARTLDIDDAGLAVFGVDPATFDSRPGALVERLEPAERARLDVTIDEAITGGSNSYNVHFRVPLDDGTTQWTHVQARILRSKDGKAHRIVGVVRDATAEVTHSAFVLDLEKRRQRQTSIVERTTSAMSRAVTVDDVTAALTGPGGLARLGADGLALGLVENSGLNIVALSGESLEALDGLGSGDLERNLPLADAIRSGRPRFITSLAALARRYPVLEPHLGRLRFRAAAYLPLVAQARSLGGLALFYRERTVFNADERILCLGLAAIVAQSLQRAMLFDEEREFATQLQSAMLPPRIQDIEGGEIAVRYHAAWSGRQVGGDWYDMIALPKNRYGLVVGDVQGHDTHAAAIMGQLRIALRAYAAEGHPPATVLARASRFLSELDTDRFATCTYAQVDLATGAARVVRAGHLGPLIRHTDGRVGSPQVRGGLPLGISTEFEDEEYPETRLDLVPGETFVLYTDGLVEEPGADLDAGVEALRNEVSAGPAGAEALADHLSDRLWERWGSGDDVALLVLRRSPDVGSSHAPRLHQYIHQADPEGLSDARAIVRQALADWDMAEFADDAELVTGELLVNVLLHTEGGAVLTLEVLPEPVRRIRLSVQDRSSAWPRRRTPGETSTSGRGLLLLDAVANRWGIEPRGEGKAVWCEIGPAPPPATAPPPGAMEQVPPAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z976</accession>
    <name>A0A7K2Z976_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_06300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000294">
        <property type="protein sequence ID" value="MYW28893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6662" checksum="1F9F20740E3D80DB" modified="2021-04-07" version="1">KWFNSEKGFGFIEQDGGGADVFAHYSNIATQGFRELQEGQKVSFDVTQGQKGPQAENIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9A7</accession>
    <name>A0A7K2Z9A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_06105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000267">
        <property type="protein sequence ID" value="MYW28855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="36648" checksum="FBDCC0F14577F320" modified="2021-04-07" version="1">MDRTTRHSETRYGNRPTMKDVAARAGVGLKTVSRVVNSEPGVTPDTERRVQEAIDALGFRRNDSARVLRKGRTASIGLVLEDLADPFYGPLSRAVEEVARAHGALLINGSSAEDPEREQELVLALCARRVDGLIVIPAGDDHRYLEPEIKAGIATVFVDRPAGRVDADMVLSDSFGGSREGVAHLIAHGHRRIGFIGDQPRIHTATERLRGYHAAMTDAGITVEDGWVSLGTTDPDRVRAAAEAMLGGPEPVTALFAGNNRVTVTAVRVIAERERPVALVGFDDIELADLLGITVISQDAAAVGRTAAEHLFRRLDGADHAPARVELPTTLIPRGSGELPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9F8</accession>
    <name>A0A7K2Z9F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000302">
        <property type="protein sequence ID" value="MYW28968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514263.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000302.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8619" checksum="9098445C678F0E78" modified="2021-04-07" version="1">MSSAGIDKVRDWILGRHPERTELAADVDLIESRLVDSLAFVELVYTIEDAAGVEIDFDTIDIEDFQTLATIEKAFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9N9</accession>
    <name>A0A7K2Z9N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000305">
        <property type="protein sequence ID" value="MYW28995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="36"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="480" mass="50468" checksum="AE9A184696AB228A" modified="2021-04-07" version="1">ALSGALARDARVLGGGSALVFPDHVVSPLDGLAAALPEGTLTYSVGADPSDELAIAEAGFELTAVCRDAEGGVLAAVPLPSGQIQWIGADLPEGVTHDALDTVEITGTFTPRESGEHTFGTRGTGSFALTVDDRPLFDGTQDRAPGTDPLGAFFNEPVERGRVPLTAHTPVRVSLNHRPGPGTGHPLKGVAFSLVHLAPLRDPDELIAEAVEAARGADTAIVVVGTTERVESEGFDRTDLRLPGHQDALVHAVAAANPRTVVVVNSGSPVELPWRNEVAAVLLTWFPGQEAGHALADVLRGQEEPGGRLPTTWPVTLADVPVSATTPTNGELPYTEGVFIGYRAWEQAGTTPAYAFGHGLGYTTWEYDTVTATPDSVTVRARNTGPRPGSDTVQIYLAPKAVSGLPERPARWLAGFARVTAAPGGSVEVTIPVERRAYQVWDEEAYGWRTVPGTYEVQAARSLADIRATTTVEVTDGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9T1</accession>
    <name>A0A7K2Z9T1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_07335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000333">
        <property type="protein sequence ID" value="MYW29093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="384" mass="41051" checksum="A6292B2D8DBF380B" modified="2021-04-07" version="1">MTTTPVVPAVPRGLAGVVVTDTTLGDVRGSEGFYHYRQYSAIELAQTRGFEDVWYLMFHGELPDRAQAADFTARTASLRALPADVTEALPAIARAGAVSGPLAGLRTALSLLGASRGHRPVYDLDADRRRADALAACAAVPTILTALQRLGQGLEPVEPREDLPYAANYLHMLTGTEPEPDRVRAVEQYLISTVDHGFNASTFTARVVASTGADLAACLVAAVGALSGPLHGGAPSRALDTLDAIGTPDRIDGWIREQVLSGRRIMGFGHPVYRTEDPRSRMLKSIAQGFGGPLVDFAVEVERQVEAILAELKPGRELHTNVEFYAGVVMELCGLPRAMFTPTFAAARVIGWSANILEQAEDSKIIRPAARYIGTPPPQPVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9V1</accession>
    <name>A0A7K2Z9V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000351">
        <property type="protein sequence ID" value="MYW29114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="81" mass="8110" checksum="E998BB36510413E1" modified="2021-04-07" version="1" fragment="single">DAHGPDATEPDASEPGPASAGLPGPRLTGPWGSPPEDPYDDDDDDDDEGPRPPRRVHLAGTWDDGPGSGRSVPAGGSGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA10</accession>
    <name>A0A7K2ZA10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flp pilus assembly protein CpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cpaB</name>
        <name evidence="3" type="ORF">GT040_07755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000359">
        <property type="protein sequence ID" value="MYW29174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029599377" evidence="1">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RcpC" evidence="2">
        <location>
            <begin position="108"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="25580" checksum="4CAE8B85A381C1F3" modified="2021-04-07" version="1">MNSRQRRGVILLLLSVLCAFGAFAGVLSVISDVNSKVGPEVTAYQLKSDVAPYTALNSGQFEKIAMPKRWLSENAVTDLREVEGKIAVTELRGGSLLQSDMMVRKPELRAGEQEIAIMIDAATGVAGKITPGATVNIYATFAGEQQQENGEPAQSKVIVSNAKVLEVGKLTALNPSGDDRRTQMTEAVPITFALNTLDTQRIAYAESFAEHVRLALVAPGSDGTIRPGDRTYTLDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA26</accession>
    <name>A0A7K2ZA26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1-hydroxy-2-methyl-2-butenyl 4-diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000366">
        <property type="protein sequence ID" value="MYW29217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="76" mass="7249" checksum="87B54B7BB128D7EE" modified="2021-04-07" version="1" fragment="single">MAGAPESTAPRVPLLVACALGIEQLALRSGKRAGGPVWVLRTGMGPRAAEAAVAAALAPGGVPGAAVIASGFCAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAE6</accession>
    <name>A0A7K2ZAE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="426" mass="46759" checksum="1566C1A31A969ED3" modified="2021-04-07" version="1">IYTSGTTGRPKGCVLTHGNFFAEVDNAIELLHPVFKSVSKDPASTLLFLPLSHVFGRMVAIGCMRARVRLGHAPSIQTEDLLADLAGFRPTFLLAIPYVLEKVYNTGRATAEKMGRASSFDRAARIAQRYGKAVEAAEHGTGPGPGLGLRAARALYDPLVYRRIRAALGGKVRYVICGGSPLGRRLAAFYEGAGIGIFEGYGLTETTAAHTVTPPLKPRLGTVGWPLPGTSVRIADDGEVLLRGGQVFRGYWDTERAEPVPYLLDGDWFPTGDLGALDEDGYLTITGRKKDIIITSGGKNVTPAPLEDWLRAHPLVSQCMVVGDNRSYITALITLEPDGLQHWRQMVKKQDVPLRELVNDEELRTSLQKAVDEANRLVSRAESIRKFVVLPVDFTEERGHLTPSLKLKRDAIARDFAGEIEELYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAH4</accession>
    <name>A0A7K2ZAH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1416 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000376">
        <property type="protein sequence ID" value="MYW29265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="9879" checksum="57FB37B83F1DFD26" modified="2021-04-07" version="1">RETRQDIELAGGAVLRGVVRATGGRPVEDARVTLLDAAGNVVDTLTTGPDGSFRFVDLSSGEYTVIAAGYPPVATVLQVAGGGRTERDLQLGHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAQ6</accession>
    <name>A0A7K2ZAQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_08980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000410">
        <property type="protein sequence ID" value="MYW29408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="23919" checksum="4748D6BE4841E998" modified="2021-04-07" version="1">MTAPPDDCLARNEWICGAYLSSRREILMDAALQHLQLTALAVLIGLGLAVPLALAARRWRWAAGPVLGLTTILYTIPSLAMFSLLLPVYGLSAALVVTGLVLYSLTLLVRNILAGLRAVPEETRQAARGMGYGPLRLLLAVELPLALPAAMAGLRIATVSAVSLVTVGAIVGYGGLGNLIYSGMNTYFKAQVLTASVLCVVIAVAADLLLLGAQRLLTPWTRRGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAX6</accession>
    <name>A0A7K2ZAX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000420">
        <property type="protein sequence ID" value="MYW29462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="13708" checksum="7370318067FBCB3B" modified="2021-04-07" version="1">CRPTEALYAAAADLLAGLRRTAPVFVLSEEDVRRLVPGVAAWLERGMRPDAVRQALTDDPPVPLRHPAKLLRHRLIALLPPPLSVAAPVIPLQNCEDCDRAFRSPVAGVCRGCGDARAEGAEPFALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB42</accession>
    <name>A0A7K2ZB42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_09795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000453">
        <property type="protein sequence ID" value="MYW29559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="73"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW29559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="23964" checksum="236F5B7B184C0969" modified="2021-04-07" version="1">MSVTEQQQGGDHPAGGDPREALQDRIAADSLTTRRDYLRIVTTVSGGLAVGGIGVAAGILHRHGDDEDGKAPEAKRIAQRLPPGESIAFRYPGEEDRAVAVRLDDGTLVGYSAVCTHLACAVLWRKDRGREGELYCPCHEGVFDARSGEVTAGPPPRGLPKVVVIEETDGSIWAVGTTRSGESVEAGLCRQLGGERPDLAARIGCPDIGGGAESPPRAPGPAASGTPGGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB91</accession>
    <name>A0A7K2ZB91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000463">
        <property type="protein sequence ID" value="MYW29626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="19055" checksum="E40C55BC1C296E1B" modified="2021-04-07" version="1" fragment="single">MPLPRLLLRSALALYLDLHAHPELSGHEHRTADLLAARLTDHGLAVTRAVGGGHGLVGVLRNGPGPTVLLRTELDALPVTEATGLPYASTTPGVMHACGHDLHIAAVTGAVALLADDRDSWRGTLLVVGQPAEETLSGARPMLEDGRLYERFGTPDAVLAQHAAPLPAGTVAHAPGGAPLMAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB92</accession>
    <name>A0A7K2ZB92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000460">
        <property type="protein sequence ID" value="MYW29604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="47"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="232" mass="25475" checksum="1104651005B23A64" modified="2021-04-07" version="1">AGPPAGLPARPPAYRLQPMTAGTPPRFRPASPPVRTRPFEELPDLGHSMVLSFDDGPDARYTPDILATLRKHRVRAMFFVCGEMADAHPDLLREMADDGHVVGNHSWSHPLIPGLSRAAIRDELGRTSDVVERVLGTAPLWYRAPYGAWNRNSFEIGADLGMEPMAWTVDTLDWTTPGTGTIVRRVMEGAAPGVVVLSHDAGGNRSQSVAALRRYLPRLLDEGYRITVPQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBG9</accession>
    <name>A0A7K2ZBG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000471">
        <property type="protein sequence ID" value="MYW29658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="123"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="497" mass="55331" checksum="5CA9F9503B019CB4" modified="2021-04-07" version="1">LFRSLALAGRPEAAWGVQVGSVTASSALVWVRSDRPARMLVETAATESFRRARRWFGPLIGPGSDFTGTTPLYGLPAGEQVHYRVTLADPGDPRRTGRPVYGTFRIAPARRRDGVRFLWSGDIAGQGWGINPDIGGYRVYEEMRRLDPDFFLCSGDTVYADGPLQPSVTLPDGRTWRNVMTEEKAKVAETLDEYRGNFRYNLLDRNVRRFNAQVPSVVQWDDHEVRNNWYPGQILDDARYTEKNVDILAARSARAFHEYFPVSTPHGSYGTSSRRSRMYRTVHHGPLLDVFVLDMRSHRNRNSPGRQADDTTGILGAEQLRWLKRSLAESRAVWKVIAADMPLGLVVPDGATDFEAVAQGDPGAPLGRELQIAELLRFIKHRKVTGTLWLTADVHYTSAQHYAPERAAFKDFAPFWEFVSGPLAAGGFPANALDGTFGPDRVFVRAPDRANVSPMESPQFFGEVEVDGDSAELTVRLRAEGGGVLFTKVLRPGRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBV6</accession>
    <name>A0A7K2ZBV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maltokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000502">
        <property type="protein sequence ID" value="MYW29819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="2">
        <location>
            <begin position="40"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="292" mass="31037" checksum="0C1E5011C8E3B81D" modified="2021-04-07" version="1" fragment="single">MSEAASTHVALAKSTRNSATTSSTVDGALLPSLAPLLHEWLPRQRWFAGKGRPVTGFALVSATEMLPLDGTAGPGLLHLLVRAQQPSPSTRPGDDCYQILIGVRSSLPTTLAAALIGRVERGPLAGRTVYDALHDPRLADLLLERFRRPGTLGSLRFERTAAIPAGLAPRVLDAEQSNSSLVYGDAYILKIFRRVFPGTNPDLELPLALAREGCERVPAPIAWFEAPGPEPLTLGVLQPFLHGARDGWQLALTALTAGRDFVPEARALGRATAEVHTALAAALPTPALHGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC08</accession>
    <name>A0A7K2ZC08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000519">
        <property type="protein sequence ID" value="MYW29873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="241" mass="26629" checksum="2C3AC92CD8C70B5C" modified="2021-04-07" version="1">MMHWFEGPLAAFDTETTGVDVEQDRIVSAALVAQDTTGGRVRVTRWLVNPGIPVPPGATEIHGLTDDHLQRNGRWPAPVMDEIARTLAESCATGRPLVVMNAPFDLTLLDRELKRHRASSLAGYMADVPLRVVDPRVLDKHLDRYRKGRRTLTDLCELYEVPLDGAHDAAADASASLELVRAICRRFSSRLERLSPAELHTLQATWHAAQARGLEAWFARSGTPEPVDPAWPLRPELPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCD1</accession>
    <name>A0A7K2ZCD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1-hydroxy-2-methyl-2-butenyl 4-diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000558">
        <property type="protein sequence ID" value="MYW30020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7446" checksum="D70BAEEEE94F85C2" modified="2021-04-07" version="1">MESAATLRTALSRGPRPVAAVRVVVDAPEHELVRIGTVRGGISAFRVLRAVLPAFYEWHRSLLLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCH6</accession>
    <name>A0A7K2ZCH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000576">
        <property type="protein sequence ID" value="MYW30060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="15076" checksum="6276D30BA7E1EC08" modified="2021-04-07" version="1" fragment="single">MPVRSAPAPVQRAVDSERAHPRTPSGTGTVTGAGMGTGSGTATPAPRTSASPATPPAPVRIRNLGPRREGGQALATPSAGTAALTPTVQRSRTLLSGRDLKVNTGAAEGFSAAPTTTAGGSPARPVVAATWRRDVQQSQPGRGTAASGAPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCH7</accession>
    <name>A0A7K2ZCH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_12455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000583">
        <property type="protein sequence ID" value="MYW30071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="587" mass="62209" checksum="DF9D2958D3F61F11" modified="2021-04-07" version="1">MIDGRFTLVERLGSGGMGMVWRAHDDALHRDVALKEVRPPDPALAEYDPEGARTLRARVLREARALARLDHPNVVTVHHIVDPGEDGYPWIVMELVAGSSLHDRLAEGPMDPAEAAELGRGILSALNAAHASGIQHRDVKPANVLLRTDGRPVLTDFGIAAIRESTSLTMTGALIGSPDYIAPERIRGTEGDPSSDLWSLGMMLYVAVEGHHPLRKATTLATLAAVLDEEVPPPVRAGALAPVLTALLTRDIPARPDAGTLDRMLAEAARPQPAPDPRSAYGSPSATQPPQPPTGFGHPTPFPTPVDAPHNPYANNPYAGPSTPQTPSPPPPPATVPTVTGDEERRHRLLRRTRIISVAATVVSAVVLAGVFWMIDPSFFRGGGGGDDSAKGNNRPDTTASAPANGRSAAPPTAAGQPVADDEESGSDDGDDGVDAPADLLTPQGARQAIAALKPLMGGTKVTDFTLYGEHASAQAQLKSNSRLYDRFSYRDGQAKNDDMGGTLMSGDKAVDLNAVDWDALPALLRTARTSLNIPEPESSYVIVDPSSPFHDDRPVLRVYVSDSYGGAFLTAELDGRVIEKNSREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCI7</accession>
    <name>A0A7K2ZCI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VII secretion protein EccB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000579">
        <property type="protein sequence ID" value="MYW30064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="19994" checksum="C8875A5B91687F92" modified="2021-04-07" version="1" fragment="single">LPGPAQLDPGAWHMCVTGPDGALPSTSGGITGVGVDQAGATTLVAGAPLETQDVGADRGVLVRGPDRTEYLVWRGSRLPLDRPSDARNALGYGSERAMPVSAAFLDALAPGPALKPPEVTGRGEKGPVLGGEESRVGQLFEVSVPGGGSTYHLLRKDGLLPLSRLEAALVLGDPATQKDAYEGRSPEARAVGADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCP2</accession>
    <name>A0A7K2ZCP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIGR04222 domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000596">
        <property type="protein sequence ID" value="MYW30092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029569916" evidence="3">
        <location>
            <begin position="27"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="333" mass="33415" checksum="70C4C3F06382B253" modified="2021-04-07" version="1">MNLVAALSTVLLLAKVAVSRSRRPSADPSATVHDLYEAAFLNGGPARVADTALTALYADGRILIGGPGIISVQRAQANDPVERAVFQALSTSPSGALHAVREAVMHHPAVQEIGDGLAQRGLLVRPADGRPVRRWGLIQGVSCFVAFPLSILLTVLQYIAHDSPFDMPFPFVVKVLPGILLGGISGLVVAASGAKRITRAGRRAAQAFRAANAYLLTPPYLVANRGLHALPDPVLQAQLIAAAQQHLRTRRSRSGFSGGRSAGYVGGAAASGFAATTVWCADSGPGHTSCGGGGGCGGGSGCGSSGSGCGSSGSSCGGSSSSCGGGSSCGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCR6</accession>
    <name>A0A7K2ZCR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000598">
        <property type="protein sequence ID" value="MYW30122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="349" mass="37974" checksum="189E892728FFA6A6" modified="2021-04-07" version="1">MRYRTLGGTGIEVSTHCLGTMMFQAGFNPDHDDCARIVHAALDHGINFVDTADMYGQGESDEIVGKALRGRRDDVVLATKVHVAMGEGPNRGGNSRRWILKAVEDSLRRLDTEWIDLYQVHFPDHTTDIEETLSVLGDLVRDGKIRAFGCSNFQADEIVEAHHVSERRALGRFRTAQPPYSILARGIETSLLPVCERYGMGVLVWSPLAFGFLTGKHRKGRPIDLGAGRAAIRPAFFDPAIAENAAKLDAVEQLVELATSIGCTLPQLAVAFTVAHPAVTSAIIGPRTMEQLGGLLQGAPVTLDDATLDRIDEIVRPGVNLYNPATALPPRSLTETALRRRPLAERAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD18</accession>
    <name>A0A7K2ZD18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000631">
        <property type="protein sequence ID" value="MYW30271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21716" checksum="681E2048D6197657" modified="2021-04-07" version="1">VQLPPRGVWRTKAGVRNALVSSWLGREIDPLPTDDGSDPVGQELVRRYLAAYGPAATADVRAWSGLAGLPGAVAALRGELVTFRDERGRELLDLPDAPRPDPGTPAPVRFLPAFDNAILGYDDRTRIIDDADRGLSVAGARVVLVDGRVSATWDVEADTGAVVVAPLRRLSRAERDEVGEEGRELAGFLSDGESRRVRVASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDB6</accession>
    <name>A0A7K2ZDB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000656">
        <property type="protein sequence ID" value="MYW30357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="8838" checksum="CE2F049F67B995ED" modified="2021-04-07" version="1">AGRGVVLATGSRPRMPPGQVADGRRVVTSDDALYAPGLTTDGRGHVRSPWIRRAGAWTESSAGSSSGRSSPGPRRAPGSSRRAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDL9</accession>
    <name>A0A7K2ZDL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SigB/SigF/SigG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_14325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000667">
        <property type="protein sequence ID" value="MYW30426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="31605" checksum="3374CC461F0E4582" modified="2021-04-07" version="1">MKVRTGNPSAARAVTDDFLSGQNRPAPSPKDSREIGRLLFARLAELEEGTAEHQYVRNTLVEIHMNLVRFAARRYRTHQAGQFEDILQVGTIGLIKAIERFELSREVDFPAFALPYINGEIKRFFRDTTWSVHVPRRLKELRSSIKAAHEDLAVHLDRAPTTSELAHHLGLPEDDVAEALIAANGYTADSLDAPLGTGADGAGSTTPSWSETLGDQDGRLQHVENLHTLAPLLAALDDRQRTVLRLRYGQELTQTEIGAHLGVSQMHVSRILKRTLAVLRAGMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDX5</accession>
    <name>A0A7K2ZDX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_15090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000716">
        <property type="protein sequence ID" value="MYW30567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="355" mass="36234" checksum="E3D8651ACCDFA865" modified="2021-04-07" version="1">MTVTEPPRAPVKAPRGYLVVGRTVAVPMRRASVLAGAGLFVLLLLAAVATLTWGRLGLDLADLPAALLGDAEGKDRFVFNRLRGPRLTVAIGVGAALGLSGALFQSVTRNPLGSPDVIGLSAGAGAGAAICALMFPGTVPVAVGALLGAVLAMALVYVSTGTGFRNPARLVIAGIGVAAMGAAVTQYVVYALERDKASVLTAYVNGSLAARSWTDATTIWLVLLAVAPLTALISRRLDIGEMGDDIAEGLGSEPRKAKTLAVVLAIALSAAAVSVSGPIAFIALTAPQIAKRLSRGSGPHLLLSGLTGGLLLVAADLCAQQLPLFEDLPVGIYTMAIGGTYLGYLLVREWRRGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE19</accession>
    <name>A0A7K2ZE19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_15260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051104635.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000719.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="22975" checksum="98DFB07F838ECA09" modified="2021-04-07" version="1">MVVDDHPMWRDAVARDLAESGFDVVATAGDGPQAVRRAKAVNPDVLVLDLNLPGMPGVQVCKELVPSHPGLRVLVLSASGEHADVLEAVKSGATGYLLKSASTQELTDAVRSTANGDPVFTPGLAGLVLGEYRRLASDPVPAASNEPKAPQLTDRETEVLRLVAKGLSYKQIAERLVISHRTVQNHVQNTLGKLQLHNRVELVRYAIERGLDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE98</accession>
    <name>A0A7K2ZE98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malto-oligosyltrehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">treY</name>
        <name evidence="2" type="ORF">GT040_15680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013797">
        <property type="entry name" value="Maltooligo_trehalose_synth_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="3"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="795" mass="85997" checksum="206751D15B68F4B8" modified="2021-04-07" version="1">MTPTATYRLQLQPDFPFPAAEKAVPYLAALGVSHLHLSPVLEAVPGSTHGYDVVDHSRVREELGGEEGLRSLAATAREHGLGLVLDIVPNHMAAVPRHNRQLWEVLREGRSSPYARWFDIDWSAGGDKVLLPVLAGPLGEQLDAFTVDVGAEVLRYGEQEFPLRAGTADLPLPELLDAQHYRLAWWRLARTELNYRRFFTVSELIGVRVEHPEVFDATHAKVLELLRDGVLDGLRIDHPDGLADPAAYLRQLNEATGGRWTVVEKILTGDEPLPAGWAVAGTTGYDALHRIDGLFTDPAGAAELLGRYREFAGPTGDRGGYWKATVRRAAYRVATHELASETAWLTRLATSVCGADPALRDHAPWALRTAIRELLVRVPVYRPYVTAGVPPTRIAEETLPDDAVRDAKAVFSVPEEAAAVDVVRDLALGRLGDGEEQTSFCARFAQTASALHAKSVEDTAFYRYVPLISATEVGGDPGQPAVAVDAFHAFATRIARDWPATGTVLTTHDTKRSADVRARIAVLSECPERWAGLVAELTGATPVAAPDPQLAWQAWQSSYGCAPLPAEELGARLEPALLKAVREAGLFTSWTEPDEAYERAVTDFVAAGPGSASGSARRLVTGFAESLAPHVRANVLGAALVQLTMPGVPDLYQGTESEYLALVDPDNRSPFRRPEGPAEEKQEVTAAALGLRRELPEVFGESGTYVPLEARGAAAGHVMAFSRSGEVVVAVTRLSLRLAEDGGWRDTMVELPDGGPWRDALNREVGREFAGGAVAAGELFGERPVALLRRVREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEA0</accession>
    <name>A0A7K2ZEA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_15555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000727">
        <property type="protein sequence ID" value="MYW30656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="20335" checksum="040C48BC45CB6D4E" modified="2021-04-07" version="1">MPAARPAQLPSQRGGADETVAAGTTVDHLTETYRAHYRSLLGLAALLLDDTASCEDVVQEAFIRVHSARNRVREPEKTLAYLRQTVVNLSRSALRRRILGLKLLSKPMPDMASAEEGAYDQLERDALIKAMKGLQRRQREVLVLRYFADMTEAQVAETLGVSLGSVKAYGSRGIAALRVVMEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF09</accession>
    <name>A0A7K2ZF09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Magnesium transporter CorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_17080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000805">
        <property type="protein sequence ID" value="MYW30944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="375" mass="41897" checksum="86866567739ED24C" modified="2021-04-07" version="1">MSMIRDLRAAVRPSLRPSLRKNSAPHNAYDTTRDPSASSAVVDCAVYRDGSRLDGAATPTPHEAMLEVREKGGFAWIGLHEPTEEEFAGIAREFGLHPLAVEDAVHAHQRPKLERYDDTLFTVFKTIHYVEHAELTATSEVVETGEVMCFTGRDFVITVRHGGQGSLRALRHRLQDDPELLAKGPSAVLHAIADHVVDGYIAVAEAVQDDIDEVEIDVFSTPAKGGRRGSDAGRIYQLKREVLEFKRAVSPLLRPMQLLSERPMRLIDPDIQKYFRDVADHLARVQEEVIGFDELLNSILQANLAQATVTQNEDMRKITSWAAIIAVPTMICGVYGMNFDYMPELAWKYGYPLVLGLIGTVCFSIHRILKRNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF55</accession>
    <name>A0A7K2ZF55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000805">
        <property type="protein sequence ID" value="MYW30948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="30444" checksum="2899A6E53322DD7D" modified="2021-04-07" version="1">MRIDLHTHSTASDGTDTPAELVANAAAAGLDVVALTDHDTVGGHKQAIDALPEGLTLVTGAELSCRVDGVSMHMLAYLFDPADPDLERERELVRDDRVPRAQEMVRKLRALDVPITWEQVARIAGDGSVGRPHVAAALVELGVVDTVSDAFTPDWLGDGGRAFAAKHEFDPFEAVRLVKAAGGVTVFAHPAASKRGATVPEATIAALAAAGLDGIEVDHMDHDEPTRARLRGLARELGLLPTGSSDYHGSRKTVRLGEYTTDPEIYGEITRRATGAFPVPGAGGTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF70</accession>
    <name>A0A7K2ZF70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF59 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000814">
        <property type="protein sequence ID" value="MYW31004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015607822.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000814.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="112" mass="12316" checksum="C79BCF8264F3CF56" modified="2021-04-07" version="1">MSENETATMKPASEEEVREALYDVVDPELGIDVVNLGLIYGIHVDDANIATLDMTLTSAACPLTDVIEDQAKSATDGIVNELRINWVWMPPWGPDKITDDGREQLRALGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFB7</accession>
    <name>A0A7K2ZFB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000822">
        <property type="protein sequence ID" value="MYW31043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="173"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="310" mass="32875" checksum="1B125D807A681727" modified="2021-04-07" version="1">MGGYHRGERAVQERAGFARQAGQARGAIGNTVPDVAVAFLAQQPHLVVGATDERGRIWATQLTGEPGFLTVPGPHTLRIGALPPPEDPLAPLLTGAGSGSGSGPVPVGLIGIEPATRRRMRMNGRAVRDGDGLRVELDQVISNCPKYIQKRDHHRPAASTPPPRKAADSTELSPAQQRTLRAADTFFVATASDRGDADASHRGGNPGFVQVLSPRLLRWPDYAGNAMFLTLGNLELNPAAGLFVPGWETGTSLHLTGSARTVWDGEEAARTPGAQRLVEFEITAVREVASASPLRWSAPAYSRFNPPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFD6</accession>
    <name>A0A7K2ZFD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000843">
        <property type="protein sequence ID" value="MYW31087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="130" mass="14020" checksum="AE624FD41BE81D72" modified="2021-04-07" version="1" fragment="single">PWGHHLTAERPRSAADRVNLGSLYVRWARAAIAGRLDPDRRGVITLGGSGRWHGMGRQTADTARTATWPFDARTGLRLLHGAEFTADPARPVRSDDLAVPADTTSADRCLLLSPPLPRPLDLAGPATARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG00</accession>
    <name>A0A7K2ZG00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000869">
        <property type="protein sequence ID" value="MYW31248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515128.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000869.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="103" mass="10382" checksum="0C7E8CD98622B120" modified="2021-04-07" version="1">MSWASWTTSGVFAGTGGVRTEEAGILSGDLTVHTTWSDGQASVAVQYSGSSDWFTLTGSPVPCASEEESRAFHQSVVEAVRAGDGATVPPDGTAPAAPPAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG10</accession>
    <name>A0A7K2ZG10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000873">
        <property type="protein sequence ID" value="MYW31266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10082" checksum="1A11E001092DA771" modified="2021-04-07" version="1" fragment="single">MAPHKAPDSSRRSDRSRRAIYDAALALVGESGYRRTTIEGIAARAGVGKQTIYRWWPSKAAVLMEAFLDLAARVAEEAAPQAGGAGGRAGGTDPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGG8</accession>
    <name>A0A7K2ZGG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_19745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000921">
        <property type="protein sequence ID" value="MYW31447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="4">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="3">
        <location>
            <begin position="303"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="599" mass="67655" checksum="170206AA3E7E53CA" modified="2021-04-07" version="1">MPLTHLDLAGHPRPQLVREADWHDLSGPWRFAFDDADLGRSERWMDPPVTAPYTDVVTVPYPPESKASGLADSGHHPVLWYRRTLTLSAPADGRRLLLHFGAVDYRAEVWLDGRLVGRHEGGHTGFSCDLTDAVRHGTEQVLVVRAEDQPLDAAQPRGKQDWRERPHVIWYHRTSGIWQPVWLEEVPDQHLTQLHWTPDVAHARVRCALRLSRWPRRALRADVRLVLGDRVLAEQRVLAEDQETVFDIAVPALRHAQDLDALLWSPESPRLVDATVVITDAEDGHEIDRVASYLGLRDIGWEDGGFQLNHKPCFLRLALQQGYWPDSHLAASADELRRDAELAKEAGLNGLRVHQKLEDPRFLYWADRLGLMLWAEMPSAFAFGTVTMERVVREWTEAISRDLSHPSIVAWVPVNESWSTPNPALVPEQRHFIDALYHLTKALDPSRPAVSNDGWEISAADIWGVHDYTQQASVLRERYGHASLRQGEFTDPWPGAKRLLLPGVEHQGQPVVLSEFGGTTFEPAEGEAWFGYDTVATREEYAERLSSLVEAAVDSGLAGFCFTQFTDTEQETNGLFTADRTPKLPPAELRAILTRPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGL5</accession>
    <name>A0A7K2ZGL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000933">
        <property type="protein sequence ID" value="MYW31501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="16702" checksum="2D015207FC3258F2" modified="2021-04-07" version="1">AVPLDDPAAVRAAVAGRDAVLSGLGSRSRKADGVAERLTGRIVDAMEAEGVRRLVVVSAAPVGPIPAGEPLVDRLARKAIGAVLADLYADLARMEAALERSATDWTSVRPPKLTDGPCTGVYRTVVGGAPVSSRSISRADVAHAMLGLIDDPAAVRQGVGIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGM9</accession>
    <name>A0A7K2ZGM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000932">
        <property type="protein sequence ID" value="MYW31496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029574669" evidence="2">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="6112" checksum="73CBC332B122CA62" modified="2021-04-07" version="1">FLAAVYLGMVLFSPDSSSADTPTPGPSSGPASQEVQEGGEQPGEQGQGQNQEEDDEQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGY3</accession>
    <name>A0A7K2ZGY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000970">
        <property type="protein sequence ID" value="MYW31602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7420" checksum="41DD713ABD94EFEE" modified="2021-04-07" version="1">MADRPAEPEDDFPHGAGNPARSALRHAGYTRLAQLTDVTAAEVLALHGVGPKAIRVLREALSAEGLSFAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH86</accession>
    <name>A0A7K2ZH86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001003">
        <property type="protein sequence ID" value="MYW31723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="168"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="268" mass="27234" checksum="0E0F45803E39E8CB" modified="2021-04-07" version="1">QGAHGRTVNPWRADRTPGGSSAGSAVAVAAGMVELATGSDGAGSVRIPAAWCGVFGLKTTNGLLPSPDRSGLASAGVLARSAAGAERYLRHVLDGYEEPAAPSLPLPAVYSEDLGFADVDPEVAAVVRAAVDRLVAAGTVRLVDADCALLDPVRAWQAVRGGSPGDPEAVAARRGNDERLEHLFATAPLLLTPVTPNRPHGHEGPGDLYSTALTWAFNLSGHPAASLPAGFTGDGCPVGLHLVAARGADVSLLGMARAVENSLPTVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHN5</accession>
    <name>A0A7K2ZHN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001032">
        <property type="protein sequence ID" value="MYW31866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="2">
        <location>
            <begin position="39"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="264" mass="28207" checksum="AF5BA8A60FDDCC53" modified="2021-04-07" version="1" fragment="single">MSERQHQAHHPYDRLPDAVTDLFGEGATAESAYDLLTVDVPATEWITALRTARDELGCSYFDWLSAVDEPGTGFRVCAHVAALGDGTVRRLMLRTTVPHDAAVLPSAIDVYAGAAWHERETHEMFGVAFEDHPGLAPLLLPEGFEGHPLRKDFVLAARVAKAWPGAKEPGESEHGGPKRRTMLPPGVPDPNEWGPLKGQLPPATARPGRAARPAATATDRPPRRTRSATEGSAAQRPQTGPPEASGPGAPESEVPESRAPAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHQ2</accession>
    <name>A0A7K2ZHQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">tsaD</name>
        <name evidence="9" type="ORF">GT040_22035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001036">
        <property type="protein sequence ID" value="MYW31882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="8">
        <location>
            <begin position="28"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="367" mass="38453" checksum="F0BB0CE6EFD7D0A6" modified="2021-04-07" version="1">MAADEPLVLGIETSCDETGVGIVRGTTLLADAVASSVDTHARFGGVVPEIASRAHLEAMVPTIERALKEAGVSARDLDGIAVTSGPGLAGALLVGVSAAKAYAYALDKPLYGVNHLASHICVDQLEHGPLPEPTMALLVSGGHSSLLLAPDITADVRPLGATIDDAAGEAFDKIARVLDLGFPGGPVIDRLAKEGDPKSIAFPRGLTGPRDAPYDFSFSGLKTSVARWIEAKRAAGEEVPVRDVAASFQEAVVDVLTRKAVRACKDEGVDHLMIGGGVAANSRLRALAQERCERAGIRLRVPRPKLCTDNGAMVAALGAEMVARNRRPSDLELSADSSLPVTEPHVPGKHQHAHDHVHEISKDNLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHR7</accession>
    <name>A0A7K2ZHR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_22130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001043">
        <property type="protein sequence ID" value="MYW31900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="2"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="460" mass="47207" checksum="C06588D67A621BAF" modified="2021-04-07" version="1">MGLFTVLLGAALPLVDFFIVNVALPTIDHDLDAGPALLELVVAGYGLAYAVLLVLGGRLGDMMGRRRLFLIGMAAFGTTSLACGLAPDAWTLVGARVAQGAAAALMLPQVLATIQAATRGPRRARAMSLYGATAGLSMVAGQILGGVLVAAAPMSSVFGESAGWRSVFLVNVPVAVVGLILAARVVPETRSDRPAPVDVPGTLLLALSLVTLLAPLTEGRAAGWPLWTWVSLGLFPVAAYAFYRVERRADRLGRVPLVPPSLLRLDSLRRGLALVVPFSIGFGGFMFVIAVALQQGLRMGPAAAGLSLAPMALAFFGASLAGPRLIRRYGTRVVTAGGLIQAVGVVVLVLTVHSAWEGLGLWGLLPGVAVAGLGQGLQLPVLFRIVLSDVPPEKAGVGGGVMTTTQQAALALGVATLGTLFLALVPGLGMRDALAVTLLVQLAAVALTTGLSLRLPRTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIC6</accession>
    <name>A0A7K2ZIC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001083">
        <property type="protein sequence ID" value="MYW32088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="436" mass="46197" checksum="2FB4D71850314EEC" modified="2021-04-07" version="1">GEGPGADRPLLGIPVTVKESYNVAGLPTTWGMPLHRDYVPAEDALQVSRLKAAGAVVLGKTNVPLGLQDVQSFNEIYGTTNNPWDHGRTAGGSSGGSAAALASGFGALSIGSDLAGSLRTPAHFCGVYAHKPTLGLAPSRGMVPPEAPALPVDLDLAVVGPMARTARDLTLLLDVMAGPDPLTSGVAHRVTLPPARHERLRDFRVLVLDEHPLLPAGAAVRAGVGRVAEALADGGARVERRSPLLPDLTEAALIYMQLLASGSSAQFPDARYEQLRARAAGLAADDRSLDAARLRGTVLSHREWIEVNYRREAHRHGWRRLFSAFDAVVCPVTPTPAFPHDHHPDPLERLIAIDGVAYPYFDQLVWAGLPTMPGLPATAVPAGRSPEGLPVGVQIVGPMFEDRTPLRLAELLERETGGFRAPERGVPARTASPRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIH1</accession>
    <name>A0A7K2ZIH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="23190" checksum="A85AF6D847367BB8" modified="2021-04-07" version="1">MTNREIAESLRMSESTVSRAMSGKGSRRLHNLLLAMVFMADGSAEEAMDLMGRLGRRRRAHLGQPNEGILGSDPDLVSTPAELVRGMRVLRIQAGQPSLAELKRRSPGRALAPTTINEVLLGQRFPSALVLARFVAACGVAPPESDRWARAWQRVMLQEQQRGWRSKAPFSLMVRFHLVEMRAEAGATFVEPFREAHEAVNGHLATGPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZII6</accession>
    <name>A0A7K2ZII6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001108">
        <property type="protein sequence ID" value="MYW32148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015608571.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001108.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="140" mass="15907" checksum="170A5369F7BFB1D0" modified="2021-04-07" version="1">MARHIYSCPLRWSDMDAFGHVNNVVFLRYLEEARIDFMFRLAPGDGSPSFSGGSVVARHEIDYVRPLVHRHEPVTVESWVTKIGAASLTIAYEIKDPDQVYVRASTVVVPYNLEAERPRRISAEEKLFLQKYLAEEPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIQ9</accession>
    <name>A0A7K2ZIQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_23910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001114">
        <property type="protein sequence ID" value="MYW32232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="23457" checksum="BAA71204643D50E0" modified="2021-04-07" version="1">MISVHRSEDRYRGGEPDAGIETRHALSFGPFYDPDNLRFGPILACNEERLAAGAGFDEHLHSHTEIVTWVVEGELTHRDSAGHSTVVRAGDVAHLSAAAGVRHVERNDGEWPLTFLQMWLAPLESGGEPAYTVVPGIADSTPYALPQAGAMLHVRRLSEGGRTALPDAARLYVHVVRGRVALDGEELGTGDAARITDAEGLEAAAVAEAAELLVWELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIW8</accession>
    <name>A0A7K2ZIW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage tail sheath family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001123">
        <property type="protein sequence ID" value="MYW32265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="2">
        <location>
            <begin position="236"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="3">
        <location>
            <begin position="398"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="515" mass="55463" checksum="8B0B0FCD6DA07042" modified="2021-04-07" version="1">MPSYLTPGVYVEEVQSGARPIEGVGTAVAAFVGFAETGPFHQPTLVTNWDQYVQTFGTFTADTYLTHAVYGFFANGGGAAYIVRIGGPAQGASDATAPGAVGQAPAPVALGGFLVAAKSGTGADLSVEIADPEGENPPEDRFKLLVRQAGKVVETYDVSTRKNVKGYLVTQARDSKLVQVTEQPGTAQSRPEKQTVALAPAPASGTPGSGVARLDASEYVGDAAARTGFGGLESIDEITMVAVPDLMSAYQRGEIDAEGVKTVQLAVISHCEQMGDRVAVLDTPPGMNAQQVRTWRNDEAGYDSRYATLYYPWVKVFDPAAGRNSLVPPSGHVAGVWARSDGERGVHKAPANEVIRGAVDLEIRLSKGEQDLLNPIGVNCVRAFPGRGIRIWGARTLSSDPAWRYLNVRRLFNYLEESILIGTQWVVFEPNDDRLWSSIRRNVTAFLTEEWRRGALFGRTAEEAFYVRCDRSNNPQESIDLGQVVCEIGVAPVKPAEFVVFRLAQFSDSTSLIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ11</accession>
    <name>A0A7K2ZJ11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_24405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001148">
        <property type="protein sequence ID" value="MYW32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="358" mass="36786" checksum="78E418B76B99989A" modified="2021-04-07" version="1">MTMTTATASPPGQAGPDPRDPAGPVRRRHRHRLLILLAALALLSVTAVLSVMVGARPIAPGTVWDALLHFDNSDEHVMVRELRVPRTVIGLVTGTALGLSGALIQAFTRNPLADPGILGVNAGASLAVTFAVAVLGFTAASQFIWFALGGAFGLTVLVYTLGSIGADRGTPVKLTLAGVAFTAVCGGFTSAMVLKSTATFDVMRFWGVGSIGGRSLDILPIALPLIGAGLVLGMLSAGSLNALALGDDLARSLGTRLALTRVSLIVAVTLLAGTSVAVAGPISFVGLMVPHIVRWFVGPDQRWILPVTCVAAPAFLLAADIVGRIVLPSGELRVGLVTALVGAPVLIALVRRRKVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ41</accession>
    <name>A0A7K2ZJ41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001152">
        <property type="protein sequence ID" value="MYW32355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512642.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001152.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="23432" checksum="8BC0DDF7084BDCBD" modified="2021-04-07" version="1">MRYELVIFDNDGVLVDSEPISNTILAGYLTELGHPTSYEESLRDYMGAAVHRVHDLVEERGGEKLPADFEATLYARTFAAFQQELVAVDGVQDLLGKLVADGVDYCVASSGSHEKIRVGHRKTGIDQWFEEEWIFSSEDVGRGKPAPDLFLHAAERMGVAPERCVVIEDSPLGVEAARAAGMDVYGFTSMMPADRLAGVTGYFSDMAQLPELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJD7</accession>
    <name>A0A7K2ZJD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001175">
        <property type="protein sequence ID" value="MYW32457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23236" checksum="ACD72EEF62D3E46F" modified="2021-04-07" version="1">MAEARRPDVRLPPLVPYDGEGLEPDGDYDGVRFDGTDLADASGPGARFMDCALDGCALDRTELTRARFMDSVLTGVRGVGTDLAEASLRDVEVVDARLGGVQLHGAVLERVVVRGGKIDYLNLRRARLKDVVFEGCVLSEPDFGDAYLVRVEFRDCVLKRADFSAVRMESVDLRTVAELDIARGVERLAGAVISPAQLMELAPAFAAQIGVRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJE8</accession>
    <name>A0A7K2ZJE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_25275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="107"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="334" mass="36999" checksum="A14B92C1AD31DB14" modified="2021-04-07" version="1">MSAADTKAVGPPVPLPPDPQPTGKPSSDGEPRVQKRKRKKGELLPYFLILPAIVAIAAVYLYPLSKTVIMSFQDMGRRELWSGEPAPWVGFEQFTNILGDPDFWWVTFRTVVFMAICVTLTMGIGLLVALLMRRLSTWVRLVLTVALIAAWSMPLMVAASIFRFMADSDYGLINTLVAKVVGEDWLGHNWYLNPVQGFGIITLLVVWGAIPFVVVTLYAALTQVPQELEEAAALDGASGYGVYKFVTWPVIKPVFTMVATLSVIWDFNVFGQIWLLRGNKPEPEYETLGLYSYSKAFESTSFSQGSAIALITVLLLSGVAVYYLRQLMKTGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJF8</accession>
    <name>A0A7K2ZJF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001183">
        <property type="protein sequence ID" value="MYW32475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="698" mass="73994" checksum="6E839E92E1E36D8C" modified="2021-04-07" version="1" fragment="single">MRVVAVWAVSTLTMLALAGILPDFQLQSDDGDTITRTAFTAAWGAGAFGLLSALVWPVLVRALLIVPALVMGALVFFLNGSLLLIAVRLIPDGRGEAAPETAVLVAAVMSAVASATSTALAVRDDEAYRRRLSRLADRRRRRGSPDIVGPDRDAPPGTLFLQLDGVGHDVLVQAAAGGLMPTVAGWLADSSGHRLTPWRTDWSSQTGASQLAILHGSNHDVPAFRWYEKETGTVMVSSRPASALEMQRRAIARTRDGGLLTIDGASRGNLFSGGAGQLALVLSMAARRGKGRRSRSGYFAYFSDPANAVRTALSFAAEVGREIGQSTRARARKVTPRVKRGGLYPFIRAFATVVERDVVVSAVLGDMFAGRTAVYADLVAYDEVAHHSGPHSRDAEKVLQRLDRSLALIAKIADHTPRTYRIVLLSDHGQSPGETFAARYGLTLKDLVRAGCGLPVPRRARGTHSASEARDAVRIALHRPPVAVEPEAEQAAKRSEPIVLASGNLGLISFPDLEGRASREQIDRRNPALLSTLANHPGIGFLLVRSEEHGSVVMGPGGTEVPVAELADGEGPLAVFGTGAAAAVRRTDTFPHVADIMVNSMYDPESGTVHAFEEQIGSHGGLGGEQSRPFLLWPRGMTDPLDIVAAEAAEGAPTPPGGGLVGAEAVHRVLNRWLLEFSGPQVPVSTEGFTGAVRADEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJW3</accession>
    <name>A0A7K2ZJW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_26040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001209">
        <property type="protein sequence ID" value="MYW32640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="27"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="31374" checksum="B7B65D5EA2EE01D0" modified="2021-04-07" version="1">MTPPDAPQNRWSDLDRPPLNVTALRRGLLRPESLWSELEVVETAGSTNSDLAERARSGGLAEGTVLVAEEQTAGRGRLERSWTAPPRSGLFFSVYLEPGDDVPVERWGWVPLLAGVAAATGLAKAAGVDTALKWPNDLLVTVPKGSDKLRPGETPPGEERKAAGILGEFAGDGIVVGLGINVSLRADELPAPTAGSLALAGAVSTDRETLLRAVLRSLEHWYGEWKSAGGDAAASGLQAAYAAGCATLDRTVRAELPGGNSLVGQAVAIDGDGRLVLSTEDGLQQPVSAGDIVHLRGAAGGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK12</accession>
    <name>A0A7K2ZK12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001223">
        <property type="protein sequence ID" value="MYW32686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="11438" checksum="B73A2D93CC94763D" modified="2021-04-07" version="1">AAYAASKGALTSAMYSLARELGPHRIRVNTVLPGWMWGPPVQAYVQFTAHTEGVPESEVLARLTERMALPELATDGDVAEAVAFLASDRARAITGQSLLVNAGELMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK86</accession>
    <name>A0A7K2ZK86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3618 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001249">
        <property type="protein sequence ID" value="MYW32764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030567707.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001249.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="104" mass="11097" checksum="2A7B87A5F0824898" modified="2021-04-07" version="1">MSDARTPAQIEADIISRREQLAVVLDEIGVRVHPKTIIGDAKAKAAQTVDRTAGRAFVTVNRSVSQVKAQFVAVDGSPRLERVIPAALLVVGVVGLITLSKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKJ9</accession>
    <name>A0A7K2ZKJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001269">
        <property type="protein sequence ID" value="MYW32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="31913" checksum="15D6E7BA4E909D46" modified="2021-04-07" version="1">MAVRGILGGRNRRTYKTPEPHPSGATPPKIPGELVPQHVAVVMDGNGRWAKERGLPRTEGHKVGEGVVMDVLKGCIEMGVKNLSLYAFSTENWKRSPDEVKFLMNFNRDVIRRRRDEMDELGIRIRWVGRMPKLWKSVVQELQVAQEQTKDNDRMTLYFCVNYGGRAEIADAAQAIARDVAAGKLDPSKVNEKTFQKYIYYPDMPDVDLFVRPSGEQRTSNYLIWQSAYAEMVFQDVLWPDFDRRDLWRACLEYAQRDRRFGGAQEAAEAAKAAEAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKP5</accession>
    <name>A0A7K2ZKP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SWF or SNF family helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001289">
        <property type="protein sequence ID" value="MYW32915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15330" checksum="37F2AA8265C9D544" modified="2021-04-07" version="1" fragment="single">GPPSGIDPAALEVLAADSAVRAHRMLLEALAPGHGRQPVPAELTPEQDAVRMAADARPEPWIAKRLAEGSGRPRAELGAAVSAWRYGGAAALAVLDEEWDPDADSLARARARLAAAWEEGERPQLRAARARWTVAGADVQLRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKW9</accession>
    <name>A0A7K2ZKW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_27960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001302">
        <property type="protein sequence ID" value="MYW33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="183"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="744" mass="80941" checksum="220753B9923466C0" modified="2021-04-07" version="1">MSNREAVELREEQEFVDRVHARVHELRGVTARHVEEALTPVGTGLQAKLERDVLVTERSGLLAALNAVDGSLCFGRIDLSDGTAHHIGRIGIREDDAEHTPLLIDWRAPVARPFYLATGHVPMGLRRRRHITSEGRTVTELHDEILDLGDEDRTGFEDRNGDAVLLSALNSARTGRMGDIVRTIQAEQDRIIRAPHRGVLVVEGGPGTGKTAVALHRAAFLLYEHREVLAKRAVLIVGPNPAFLRYIAEVLPALGETGVLLATQAELFPGVNATGTDTLRAAAVKGSAQMAEALALAVRDRQQLPEPGAPLAIPHDDGDLVLDWEIAYEARQAARDTLLPHNLARPHFAFRVIDALTAQLTERIGADPYGGPNFLGPDDIAQLGKAVAMSGEVHEAIESLWPELAPEEFLAGYLAEPVYVGDADADALRRAPDSGAWTPADVPLLDEAAELLGADDSAARAAAEAERQERIAYAQGLLELSRGSETYEFEDEESEVLAAHDIIDAERMAERHEETDHRSAAERAAADRTWAFGHIIVDEAQELSPMAWRLLMRRSPTRSLTLVGDPAQTSEEAGVGSWEKILQPYVGDRFEHVTLAVNYRTPAEIMELAARVVRERNPSFVAPGSVRSTGEEPWVRDAGEDLAGAVAKAVAELTPQEGRLAVIAPRALHEEIAAPLEELTAGAEPDLTQPVVLLDPRQAKGLEFDHVLVVEPGRYGTSDLYVALTRATQRLGIIHREALPSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL50</accession>
    <name>A0A7K2ZL50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="30368" checksum="8EA5703E1A638E51" modified="2021-04-07" version="1">MRPRSGPTVQHRVLAARLRILREQAGVSLRAAADALDAHPATVRRIERAETGLDARQVAELLRRYGAPPAVADPILTGLGAANLPGWWHQWRDAMESWQQDVIGVESSASLVRTWHPALVPELLRTSAYAAGLYRMQYPDDTPARHERRLELLGERRRRLSECGTALWALFPAAALHTRVGDAETMAGQRRALTEAMEQQHITVQVVPLDHPPHALTAMPPLHLLRVPAPEIGDQAVLETPGVRVDLIDDPDAVMAHRIRLDAASAAAPPPGTPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMA6</accession>
    <name>A0A7K2ZMA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="294" mass="32973" checksum="AFA602851C1CC9C1" modified="2021-04-07" version="1">MLERLNEAMDHIESHLGERIEAAELARIAMTSEYHFRRMFSALAGVPLAEYIRRRRMTLAGAEVLGHPDRTLLDVAVRYGYDTGEGFARAFRSVHGIGPGEARRSGAVLRSQQRLTFRLVVEGSSAMRYRLVEKEAFRVVGRKARVPLIHEGPNQAIAEFIRGIGRQELDRIAALSDQEPAGLVGVSDQLDPSRAEGTGLDYYHGVVTGLQEPPEDLNSLHVPAGSWAVFESEGPFPQALQYLWRDVFTQWFPSNPYASRPGPEILRVRLYEEGERAEAELWIPVERTDRGPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMB1</accession>
    <name>A0A7K2ZMB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001404">
        <property type="protein sequence ID" value="MYW33487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="27241" checksum="6C97FB9E28A00D6B" modified="2021-04-07" version="1">MSAPDYLPGHGLLTGRTAVVTAAAGSGIGGATARRFLEEGARVVIGDAHARRLKESAHALAEEFGPDRVTALTCDVTDEDQVQALFAHAEEAHGRLDIVVNNAGLGGTAELTEMTDDQWTKILDVTLNGTFRCTRAALRSLQAAGTGGVIVNNASVVGWRAQRGQAHYASAKAGVMALTRCAALEAADYGVRVNAVAPSLAMHPHLAKVTSAELLAELTEKEAFGRYAEPWEIANVIVFLASGYSSYMTGEVVAVSSQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMT2</accession>
    <name>A0A7K2ZMT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_31470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001440">
        <property type="protein sequence ID" value="MYW33665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="556" mass="59633" checksum="A694B90B5C73D581" modified="2021-04-07" version="1">MQTLAEGLRLPTNGLDYAILAIYFVVVLGIGFAARASVKTSLDFFLSGRSLPAWVTGLAFVAANLGATEILGMAATGAQYGVAVVHWYWIGAIPAMVFLGLVMMPFYYRSKVRSVPEFLLQRFDRSAHLLSSILFAFAAILIAGVNLYALSIVVEALLGWPQWVAIVVAGLFVLVYITIGGLSSAIYNEVLQFFVILAALIPITVLGLKRVGGWDAMSDSLTKQHGGDFMTAWGGTGIGDANPLGANWLTIILGLGFVLSFGYWTTNFAEVQRALSAKNLSAAKRTPLIAAFPKIFIVFAVMIPGLVAAVIVPQIGTPDSDLTYNDAIPLLMQELLPNGVLGIAVTGLLAAFMAGMAANVSSFNTVFTTDIWQRYVVKDKPDTYYLRFGRLITAIGVLASIGTAFIAASFSNIMSYLQTLFSFFNVPMFVVFIIGMFWKRASMKSGVWGLIAGTGAAMVNYFWIYKGGVIDIPSDQGANFVSAIVGFVAGAVVMVVVTLFTAPKPDAELAGLVYGTESPDPDEALEEADKAWYRKPALLGWGAIVLAAACYIPYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMT3</accession>
    <name>A0A7K2ZMT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001441">
        <property type="protein sequence ID" value="MYW33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="21939" checksum="72B149EB88647DB1" modified="2021-04-07" version="1">MTDEGRETDDGGGPLRVAVIIGSTREGRIGDAVGRWFVERARVRSELDLAVLDLAEFDFPVHYPERATEQMTEFAGAIGRAEAFVVVTPEYNRSFPASLKQAIDFAYDEWQTKPVCFVSYGHGSSGLYAVEQLRSVFTELHTVTLRNGVALDFLHTPLEDRAGACARDRAVRLMLDQLGWWGWALREARAVRPYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMT4</accession>
    <name>A0A7K2ZMT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer protein TraB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="665" mass="70903" checksum="C11D7E78AB8A4825" modified="2021-04-07" version="1">MADSPKADLWKAAKHPRMRPWLTVAAEVPATFAAHHYWGDSVPAAIGLTVAAGVLTAATWWAAEGTRPGRRIHATLSTGLGTSYLVVGTVTGPFDPAMASTLVIGGAVAAGSWNIRQALRVNVDPQKTGGNAETGVLVKAIGDAKVALRGKPKIEPNKVTAPLQLAAGQVTSDDLGNRIKHIAGELGVSPTSIRVIPDPDDAARATLVVVPKDELKQPTPWPGPSSPGGSITEPVIPGIYEDGEEATLWFPAGPGRNATHFLTAGMNGSGKSAGQSVAITEALTRRDTIVWAVDPSKGMQTFAPFLPHLDWVEMTEAGGNEMIDALSQVITARANHLGQHGYKNWTPDAFDQLGMPYLIVWIEEAAKFFRNGTEMEGLVMEARSAGISVIISLQRPSATSMPTDVREQLGGVLCFGVKGSTTADMALPDDVRDAGARPEAWENRKPGYAYLVAPGVDEDRYATPLRTYLIEDDQITGALAILPRTPIDPVTANAAGDAYANRTRYDADSPLASNDTDRQEPVLMTKDDNEAAEKALLEKQVDREIDAMVGDDPDDDGYVPDVDAEQEIAPVQEVWSFGRAQAPLEEKTPEAGMEALMAMLDGFRAEGRESIGPKDFGPFGKGERIGRARSWVSGALGDLSDAGIHLSETDKPGVYRLLYPELAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMX3</accession>
    <name>A0A7K2ZMX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="8342" checksum="43C1871FCC6CF7A1" modified="2021-04-07" version="1">MEPPPPTVGTLLIDTSRGNRVGEFRGVAGLYWSLRPVGGGREWEVEPRHVRPALPIERLRARTARANARSRGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNA9</accession>
    <name>A0A7K2ZNA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lipA</name>
        <name evidence="8" type="ORF">GT040_32405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="325" mass="36466" checksum="72739859883CC1CA" modified="2021-04-07" version="1">MSAVAPDGRKMLRLEVRNSQTPIERKPEWIKTRAKMGPEYKQLQNLVKGEGLHTVCQEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPQALDRDEPRRVGESVVKMDLNYATITGVARDDLEDGGSWLYAETVRQIHTLTAEREAGATKVELLIPDFNAEPEQLAEVFSSRPEVLAHNVETVPRIFKRIRPGFRYERSLEVITRAREAGLVTKSNLILGMGETREEVSEALQDLYDAGCELITITQYLRPTVRHHPVERWVKPMEFVELKDEADAIGYSGVMSGPLVRSSYRAGRLFQQAMEARGAAAGSVPTAQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP73</accession>
    <name>A0A7K2ZP73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_34005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001550">
        <property type="protein sequence ID" value="MYW34156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029462531" evidence="2">
        <location>
            <begin position="30"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="71"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="35749" checksum="6F96829602081E70" modified="2021-04-07" version="1">MNPSASRRPRRTPVLMAGAVAALLVGVSACGTSDDSSDTSGSASPAASEGAFPAKVTTKFGEVTVDKQPKRIVALGWGDAETVLALGGQPVGASDWLPFGGEGVGPWAKGMYDKAPELIGTMEPEFEKIASLQPDLILDTKSSGDQTRYDTLKKIAPTVGVPKDGDQYKISWEQQTTMIAAAMGVPEKGKELIAETEKKFEAAAKAHPEFKDATIVLGSRTSEGYGAYVGGTGRVDFVERLGFKNSPAVEAKAGEGFSVSISKENLELLDADLTVMTPIGIPATDISNDPLYKAVPSVKAGNSLIFDDQIISQAFATDSVLSVSYALEKVVPLFAEKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP95</accession>
    <name>A0A7K2ZP95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyclic terpene utilization AtuA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001553">
        <property type="protein sequence ID" value="MYW34175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="575" mass="60232" checksum="54537DE53F10A77B" modified="2021-04-07" version="1">MSAPAPAPLRIGNASGFYGDRFDAVREMLTGGPLDVLTGDYLAELTMLILGRSRLKDPEKGYATTFLRQLEEGLGLAHERGVKIVTNAGGLNPAGLADAVRKLAAKVGVPVTVAHVEGDSLPVPDGFLTANAYLGGAGIAACLRGGADIVVTGRVTDAALVTGPAAAHFGWGPDDLDALAGAVVAGHVLECGTQATGGNYAFFGEHDVRRPGFPLAEIHADGSSVITKHDGTGGVVDLSTVTAQLLYETGGARYAGPDVTARLDTVRLTPDGPDRVRIDGVHGEAPPPTLKAGLTRLGGWRNEVVFVLTGLDIEAKARLVKDQLADALARGGARPPADVRWELARTDHPDADTEERASALLRLVVRDQDADAVGRTVSGAAVELALGSYPGFHVTAPPGKGAPYGVFEAVHVPAGEVEHTAVLPDGRREIAETPSTTRELTEVDEPPLPAPYPSGPTRDAPLGLIAGARSGDKGGDANVGVWVRDDDAWRWLAHDLTVERFRRLLPETAELTVVRHVLPNLRALNFTVHGLLGEGVAAQARFDPQAKAVGEWLRSRRLPVPVALLEGIDDPEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPM3</accession>
    <name>A0A7K2ZPM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001589">
        <property type="protein sequence ID" value="MYW34293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="399" mass="42770" checksum="A533C09668101C6F" modified="2021-04-07" version="1">MSTTAAGPLTGLKVIDLATLFAGPLAATMLGDFGADVIKVEHPRKPDPSRGHGPAKDGVGLWWKLLGRNKRTLTLDLSAPGGRDVLLQLAAETDVIVENFRPGTLERWGLGPDELHAVNPRLVLARVTGFGQFGPYAHRPGFGTLAEAMSGFAAITGEPDGPPTLPPFGLADSIAALATAYAVMAALAGREKTGEGQVVDLAIIEPILTVLGPQPLWYDQLGYVQPRTGNRSRNNAPRNTYRTADGHWVAVSTSAQSVAERVMRLVGRPELIEEPWFGSGTTRAEHTEELDGAVGHWISRHSREEVLNGFEKAEAAVAPIHDVREVMEDPQYRALGTIAEVDDPELGPLRMQNVLFRLSETPGAIRWAGRPHGADTEEILAGLGLSETRIAALRDQGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPR8</accession>
    <name>A0A7K2ZPR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">GT040_34700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001588">
        <property type="protein sequence ID" value="MYW34288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="52"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="567" mass="61414" checksum="317A08992F33A9FD" modified="2021-04-07" version="1">MAQVQRMSRLMIKTLRDDPADAETLSHKLLVRAGYVRRNAAGIWSWLPLGKKVLDNISNVVREEMDAIGAQEVLLPALLPKEPYEASGRWEEYGDLLFRLQDRKGGDYLLGPTHEEIFTQTVKDQCTSYKDLPVMLYQIQTKYRDEARPRSGVLRGREFQMKDSYSFDTTDEGLAHSYALHRAAYIKIFERLGLDHRIVSAVSGAMGGSASEEFLAPAAAGEDTFADCPNCDYAANTEAVTFALAPVDGSAHGAVEELDTPDTPTIETLAAHLGVPASATLKNLLVKVDGEIVAVGVPGHREVDLGKLGEHLAPAVVELVTAEDFVGRDDLVRGYVGPQGLEKVRYLADPRVAPGTAWITGANKDGKHAKNVVAGRDFEVDQYLDVVVVEEGDPCPKCGTGLTLDRAIEIGHIFQLGRKYADTFQLDVLGQQGKPVRVTMGSYGIGVSRAVAALTEQTADDKGLCWPREIAPADVHVVAAGKALQTELALDISEKLNAAGLRVLVDDRPGVSPGVKFTDSELIGVPKILVAGRRSADGVLELKDRRTGEREELTVDEAIARLTADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ21</accession>
    <name>A0A7K2ZQ21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF262 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_35665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001626">
        <property type="protein sequence ID" value="MYW34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="3">
        <location>
            <begin position="9"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="4">
        <location>
            <begin position="425"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="2">
        <location>
            <begin position="595"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="875" mass="97186" checksum="5289DDB04C467F8A" modified="2021-04-07" version="1">MHAQETTFSKLVHGEAQFQVPLYQRTYTWQRDELSQLWDDVLELVEDKRAGNEPAAHFLGSVVLAPERVAAGGMQRWLVVDGQQRLTTLMLAFTALRDRHRACRREKKAARIHDLILVNGYQDGHDHYRLLPTQADREAFVACVDSLPTAGGAGNIGGAYRYFLAVLTEGEEAAEQDGSGEQWIGAVESVLRDLLSIVSITAAEGDNVYRIFESINNTGVGLSQSDLLRNYLFMCLPRRGEAVYRNLWLPMQELLGPSRLELLVWLDLVVGGDSRAKQSEIYRDQKKRLEPLSSDEEALEAEVLRLRVRAGRLMRIVEPWRESDPRLRDVLERLARWSGQTHYPLALLLLDRLDEGDCAPGEAATALSYAESYLVRRLFAGNSTTGNNRTFMQLPKEVERELENGRPLADAVRQALSARTGTGVWPSDAVVRASIRSRPFYKSGRSNQRFEVLRRFEESFGASEPVDFTRARLTVEHVLPQRPAQQWFDLLAEEAGASESPEELHAQLVHTLGNLTLSGDNARLSNHPFHRKQQILDSSALRMNQRIAGVERWGRAEILSRADELAELALDLWPGPLDGVVHADAEWAGWGELRQALLSMPAGTWTTYGDLATLIGTHAVAVGNHISTRPALHGAYRVLMADGKISPGFRWPEGHTGASDPRAVLESEGVRFDDRGRARRSHRLTASDLATLVGRDDFGNEAPAPESDGAGAEGESAATRFEKLLHDNQTPDTVAGVLSCLRFWTERGGVLTYGRRSETSCSPTLPLAGSRARSVWPLALYPVTGTVEVVFQHLRRRPPFDDEQFRRELMARLNGVEGIDLAAAKLDLRPAFPLEVFAEHGEQLRGILEWFAHTVESAQARASAEEAARGDGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQA4</accession>
    <name>A0A7K2ZQA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_35930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001633">
        <property type="protein sequence ID" value="MYW34523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029660066" description="NlpC/P60 domain-containing protein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="228"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="36926" checksum="D1AE3D11BFB5C9E8" modified="2021-04-07" version="1">MASHRRPKQPGNGYASVLTATAAVSVALSASPASADPLPDPNKKGVQAQIDRLHEEATQATEKYNGAKENAEKLRKEADNLQEAVARKQEDLNELRRGLGSAAAAQYRSGGIDPSVRLLLSSDPDAYLDEAAVLDRLGARQSQALHRFLSEQRALQQQRTQAGAKLTDLQDTRKELGSRKKEIQGKLAEAQRLLNTLTAKERAAIAAKEERANRSSARVELGNEASASGITAAAFAAARTRVGTPYVWGATGPGSFDCSGLTSWAFRQAGVNLPRTSQAQANAGTRISSLSALKPGDLVIMRTDLSHVGFYAGNGQILHSPKPGAQVRYESMARSGMPFMWGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQI0</accession>
    <name>A0A7K2ZQI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_36495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001660">
        <property type="protein sequence ID" value="MYW34634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029471898" evidence="2">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="29903" checksum="287CF160DE5241BF" modified="2021-04-07" version="1" fragment="single">MLDLSRLRALHAVSVHGSVAGAATALGYTPSAVSQQITKLERETRTTLLERRGRGVSLTEEALHLVDAAQQLLAIVERTETVLEERRGLPTGRLTVGAFASAARGLLPGVLAELGRDHPALDVRLDEVDPHLSVDLVAKGVIDLAVAHDWDIAPLPAPDGLAQAVIGLDRCDLLVPAGHPLAGREAVRREELARERWICSPPGTVCHDWLTRTVRTAGYEPDIRHRAEEHHTQLALVAAGLGVAMIPRLGRGTLPAGVVAVRLDPVPERRLYALWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQK6</accession>
    <name>A0A7K2ZQK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_36215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001642">
        <property type="protein sequence ID" value="MYW34578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029778203" description="Histidine kinase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="261"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="482" mass="51808" checksum="C400B6F385F015E3" modified="2021-04-07" version="1">MRAFGLRTRLLAAFLLVAAVSAGTTSALTYREARNALLKTTQDTAVATFREQVQQTGFGLPIQGEGLEEVLRDLARKGKPRPWVVFAEYGSLRASSGENPVSSVITPQLRRAALANPYGGFERVVKDGVPYLTIAMPTVFKTGPYSTLPSGLVLYAVMRMTDEQINVDALLTAARDGALPGLAVALVPGLIAARSVLRPVRELRGAASSMGSGRLDTRIAVRGNDELADLAATFNESAAQLEDSVNELREAEARARRFASDVSHELRTPLAGMLAVTEVLDEDADHLDADTARAVRLVSAETGKLAVLVEDLMEISRFDARAAELNADEVDVAEAIRKTLQNRHWHEDDRVHAELPAGIRARLDPRRFDVVIANLVGNALRHGGEPVTVGLRTGERPKGTPVLIMEVTDRGPGIRAESIPYIFDRFYKADAARTRSAGSGLGLAITQENVRLHGGTIRAGNRPDGGAVFTVEIPLDTGEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQL1</accession>
    <name>A0A7K2ZQL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_36660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001676">
        <property type="protein sequence ID" value="MYW34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513484.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001676.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="29446" checksum="5D1A6E1E4674AF88" modified="2021-04-07" version="1">MSQPAKSPRATAASDAPETPAGTRAAAQRLKMRRELAAAAMELFATKGYEATTVDEIAGAAGVARRTFFRHFRSKEEAIFPDHDDTLVRAEAVLNAAPAHEHPLDTVCRGIKEVMKMYAAKPAVSVARYKLTREVPTLREAEIASVARYERLFTRYLLGHFDERDHHVGNDDPLLAEVAASAVVTAHNHVLRRWLRADGQGDVEAQLDRAFAIVRDTFGTGIGAGRTAPSEPATTPAATVASEGEVLVAVARTDAPLDEVMRTIQQALKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQM3</accession>
    <name>A0A7K2ZQM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001676">
        <property type="protein sequence ID" value="MYW34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="268" mass="28829" checksum="C354967FD0C89C68" modified="2021-04-07" version="1">MRSPEDVIETRDLFDREMRERARPDGPGVRVERAGPVVRQVGGPDDWNGVVWSDPGLDAAGADAAIAAQIEHCTALGLPDFEWKLYAHDRPADLGDRLRAAGFVPEEPETLLVAPTALPAGPMELPEGVTLRPVTDAAGAELMARAHGRAFGTDGTRLLHQVMKRLEEAPEDFVAVMAVDAGGEPVCSGRMELYPGTGFAGLWGGGTVAAWRGKGIYRALVAHRARIAAERGYRHLQVDATDMSAPILARLGFTELGTTTPYVYRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQU2</accession>
    <name>A0A7K2ZQU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoC</name>
        <name evidence="5" type="ORF">GT040_36625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001675">
        <property type="protein sequence ID" value="MYW34658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="4">
        <location>
            <begin position="100"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="241" mass="26785" checksum="553F22E311A8BB3F" modified="2021-04-07" version="1">MSDHTHGEGQNGNSVPAPRDTGGEVIRVRKGMFGANNGGDTSGYGGLIRTITLPGASSRPYGGWFDEVADELEGALEEQDLLPENAIERTVVDRDELTFHIAREHLVQVARTLRDDPALRFELCTGVSGVHFLGDKGRELHAVYHLRSLTHGRIIRLEVSAPDSDPHIPSLVEVYPTNDWHEREAYDFFGLIFDGHPALTRIMMPDDWQGFPQRKDYPLGGIAVEYKGAQIPAPDQRRSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQX3</accession>
    <name>A0A7K2ZQX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001685">
        <property type="protein sequence ID" value="MYW34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_9" evidence="2">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="SIP" evidence="1">
        <location>
            <begin position="60"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="177" mass="18776" checksum="C1EB9D92B7795821" modified="2021-04-07" version="1">MGQAMPVSYVRVTGVQRITPRTARVTFTGDALPRLMEDRPDQQMKLCLPREGRSVAEGLLPSTTSALVYAEIADAGEELELPAAAGGVEVRWVHRDRGGSLVAAVRGAGAGLDGVDAAWVAGEASAVRALRRHLVGERGLPKGAVEFSGYWRRALTQDDAPAEEDLAWAAERAADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRE4</accession>
    <name>A0A7K2ZRE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_38165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001731">
        <property type="protein sequence ID" value="MYW34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="226"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="747"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="769" mass="79590" checksum="95CE1397D019B57B" modified="2021-04-07" version="1">MPSSPASQARAGREAAPQRRGVLRRTGEWCARHFVTVLVLWVAALAGLQVLQHAYGGDYSDDFSLPGTQSQDGLDVLKAHAPQAGGYSAQVVLHDADKPLTSVSDQVATAVADLGKLPDVLSAQNPLPPSGSTPPPPPDPNTGPLSTDRKTAYITVRFSVQPSTLGASYLDGVDAAVKPLRSTGVEVEYGGPLGELARPEPSDRTSEAIGFGVAVIVLLIGFGSLLAAVLPLLTALICALCGLALLGLLAAAATFATVSPTLATMIGIGVGIDYALFLVTRHRQNLIDGQDPVTAAGNAAATSGHAVLLSGCTVIIALSGLWVSGIGFIGKLGLAAAVTVVTAVLGALTLVPAILGLIGRGIDRVRVRKPVAETVPAQDGAEVGGWHRYAQRVERRPWWFLAGGVVLLAVLSFPVFFIQLGHIGDGADPKSFTDRRAFDLMSSAFGPGSNGPLTLVIDQSKVPSSDRSALADQAQKALTNVPDTAVITPLTATSDGDVLTATAYSVASPQDERTTSLTNRLTDDVLPQAVSGTAADTYVTGTTAAQVDFLDIVAGRLPLIIAVVVALAFLVILAVFRGLLVAVKAAVLNVLSIAASYGVVVAVFQWGWGGPALGVSGKVPIESYVPMMMFAIVFGLSMDYEIFLLSRIHEAWVRTGNARASVAHALEITARVITCAALIMVSVFAAFIISDNIVVKMLGLGLAASVLIDATVVRLLLVPAVMTLLGRSAWWIPGPLDRILPHLDAEGGAQESGQSPGGVKDMTGGGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS00</accession>
    <name>A0A7K2ZS00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001776">
        <property type="protein sequence ID" value="MYW35123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="161" mass="17861" checksum="49F8E4F79A6EEDE1" modified="2021-04-07" version="1">MTEKTIPLLPCRTELIQSVVDFYTALGFETTHLQKSPYAYAVVQRGAVELQLYGMKDHAPATSHSSRYVLTEDVDGLHAALRSGLKAAYGHIPTRGLKPEDEQPTPVQRVQLVVLRGDIAQRLGDEEGARGWLEEAATVRLSAEERETAHDALARLSDLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSJ7</accession>
    <name>A0A7K2ZSJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="17032" checksum="C164B978BB83ED47" modified="2021-04-07" version="1">MTTNRGRKDVIRDRMAATGESYNVAARNLKAMKDTAATRDAVLVQRWAPADSFDVPCPCGGTCEPGETCDHCHARHRHVKRYPGSTTEVETWADRYECTGCSSSYTLTIHLAGRPWGVAETVVQGGSAEEVVQATVFPGVIHPLLRSEAAEDAQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZST4</accession>
    <name>A0A7K2ZST4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001843">
        <property type="protein sequence ID" value="MYW35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="16184" checksum="251745DC261609A1" modified="2021-04-07" version="1">AVAIVVAIGAGGSVYAFMNNKGGDTPTPGPSASASGHTAGTGADGGVPDDYLGTWSASLPGDRGASTRKLTIRQGDVGDQVLSLTAEGPLALGATYHCEFTAPLAARPADGEPVRIGPSTVSVGRPAASCSPGKATELTLLPDGTLRRTTTASGESLIYTRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z679</accession>
    <name>A0A7K2Z679_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000029">
        <property type="protein sequence ID" value="MYW27849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="10241" checksum="A709B05D8C696656" modified="2021-04-07" version="1">YPQIRPTSGYGDPRVRHTGPGPGAGTDQEPERSSKLTARLALAMTVVVGQLWGLTVLIDEWMEGNAGTAWWGAGFLCLSFLVVLGLWLMDPKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z680</accession>
    <name>A0A7K2Z680_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diaminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DABA aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ectB</name>
        <name evidence="6" type="ORF">GT040_00640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.6.1.76"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000018">
        <property type="protein sequence ID" value="MYW27813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047307">
        <property type="term" value="F:diaminobutyrate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012773">
        <property type="entry name" value="Ectoine_EctB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552:SF2">
        <property type="entry name" value="PTHR43552:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02407">
        <property type="entry name" value="ectoine_ectB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="420" mass="45908" checksum="1A047313CE3D228D" modified="2021-04-07" version="1">MTITPPALSVFETLESEVRSYCRGWPAVFDRAQGARLTDEDGHSYLDFFAGAGSLNYGHNNPVLKRALIDYIERDGITHGLDMATTAKRAFLETFQNVILRPRDLPYKVMFPGPTGTNAVESALKLARKVKGRESVVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARPEWLRALKELCERQDMLLIVDDIQMGCGRTGGFFSFEEAGIVPDIVTLSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALDAYWADGRVEQQTKERGLQVEQALLAICAEEPTAQFRGRGLVWGMEFEDPARASAVCARAFQLGLLLETSGPQSEVVKLLPPLTITTEELDEGLRTLARCVRETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z690</accession>
    <name>A0A7K2Z690_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_00850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000032">
        <property type="protein sequence ID" value="MYW27854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="171"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1146" mass="123029" checksum="C6342A7FDD295A55" modified="2021-04-07" version="1" fragment="single">VGVGGELYVGGLLLGRGYVGAPGLTASRFVANPFASDGSRLYRTGDLARYAPDGSLDFLGRADNQIKIRGMRLEIEDVEASLAEHPRVRHTCVVARKNSAGGTYLVGYVIPSGGGEELTADEVTAWATAHMVEYMVPAHLVVLTEFPLTANGKIDRAALPEPTRPTGGLVAPATENERLVCAAVAAVLRVDGVGVDQDFFQLGGDSILAISLLSALRDAGLHVTARQIFTHSTVGALAAVASRDDVSTVDHADTPTGSVVGSPIVQWLGETTGAIDGFVQSVVLNTPPELTPDALDAVLAALPDRHDMLRARLVRGERWSFDIPQAGHAVVEWQEGNGTLEECVERATEGLDPDNGVMLRAVWRRAAHQLVLVAHHVVIDGVSWRILMDDLATAWRQHTTGAPVELPPVGTSFRRWTQLLERAPFDADRTYFQRTLPGEDAPIGRRALTEADTVARERTRTFSAGPEETAALLGEIPAKFHAGVNDVLLTALAVALARWRRDRGQEQTFAHIELEGHGREGRFVADAAGFEPELSRTVGWFTTLFPVTVDPGAAPDLTDPAYLAAALKAVKEDLARVPGNGLSYGALRYLGDTGLTASAPQVLFNYLGRFDAGVAGDWQLVGATGQLGEKRDPRMRLPRALEFNAIAEPGDDGAYELVTTLSWPEGVFTDEDIATLGAYYGTALSALAALEEGGHTPSDFPLVPLTQADVGDLDGAVLRDVLPLTPLQEGLYFHSVFDDDATGSYVEQQLLTLEGEVDADRLAAAATRLLTLYPNLAARFTALADGRVVSVVESGTRAPFTALDRPGITDDEIRDLAERDRRTGFDLATGPLMRYTLIRAGAGRTVLVQTVHHIIADGWSVPPMLRALLAEYHAPGSVYPLGGYRDYVRWLAEQDQDESDRVWREELAELPGPSLVAEGHAPSEHFADIAADPADDVDVAARSAGFPVSVAVHSAWAVTLGSLLHGRDVVFGSTVSGRDAEVPGIRDMVGLFINTIPVRARWSATDTAYDLLTAVKEHQSAVLAHQHVSLARIGRQAGAGSLFDTLVVFDVATDVDALRGPDDTLAITAIVNEGAPHYPLTLVVERAGDGRPRFNLIYDGELLRRASAEAILHTFTRTLTELLSRQDARVDELARAADRVPERVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6I9</accession>
    <name>A0A7K2Z6I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_01375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000060">
        <property type="protein sequence ID" value="MYW27956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="27794" checksum="710EE4A29BB0F1DD" modified="2021-04-07" version="1">MSTAPAPETGTTTAALTVSDVTVRFAGLTALDSVSFTVEPGSVHAVIGPNGAGKSTCFNVLSGVYRASAGTVHLGTTELTGLPPHAIAALGVARTFQNIALPPHATVADSLLLGRHRLTRSGFLATGLRLPSAAREERRHLDRVREIAAFIGLEAALERPAGSLPYGQQKLVELGRALCMEPRVLLLDEPIAGMTADERRRTAAVVADVRDSLGISIVLVEHDMGVVMRLADAVTVLDFGRRIAGGTPAEVQNDPAVVQAYLGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6L7</accession>
    <name>A0A7K2Z6L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000061">
        <property type="protein sequence ID" value="MYW27962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6170" checksum="4C902C5C060215A0" modified="2021-04-07" version="1">AAWALGVSQGTLDPRTPPAWQGASAQVLEPGDELAVGRAVRQQYGATRDQIHPGAFGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6R2</accession>
    <name>A0A7K2Z6R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_01790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000076">
        <property type="protein sequence ID" value="MYW28034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="359" mass="37073" checksum="0E386B5DE07EC3DB" modified="2021-04-07" version="1">MSDAPTTTVRVRPSGYSVVKAGPRGRFLLHRRSSVVAAALVVLLAAVCVAYLCVGESFVAPGEVVKVLLGQPSSAELVVGTLRLPRMAVGLLVGAAFGIAGALIQTVARNPLASPDIIGISQGASALTVGAMTFGITSYTFLPYLSVIGGIAAAALVYVFAWRGGLHATRFVLIGIGFAVALRSVTTLFLTKGDYLVAQQAQIWMTGSLNGRGWPEAAPLAWTLLLLLPAVAWAARAQRTVAMDDDTATALGVRLGRVRLGLVALGVVLASVATGTAGPVDFVALLAPQIARRMTRTAQIPLVSSALLGAVIVVLGDLLARRLFSPTELPVGVLTAAVGAPYLIWLIIRGHRGRSGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z752</accession>
    <name>A0A7K2Z752_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF993 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000104">
        <property type="protein sequence ID" value="MYW28142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009334">
        <property type="entry name" value="DUF993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06187">
        <property type="entry name" value="DUF993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="384" mass="41269" checksum="BA12EE727587A4B7" modified="2021-04-07" version="1">MRTPVLLPQGPYAPRATPLDLAAGGAPPTSRTVFSAAHVVADPYADISPDDPAAVDWESTLAFRRHLWSHGLGVAEAMDTAQRGMGLDWAGAAELIRRSAAEAKAVGGRIACGVGTDQLRPSAEPTLAEVRSAYEEQLALAEANGVQPILMASRALAKAARGPEDYLATYAHLLRQSRVPVILHWLGPMFDPALEGYWGSADLDEATDTFLKVIAEHPDKVDGIKISLLDAAREIDVRRRLPSGVRCYTGDDFNYPELIAGDERGFSHALLGIFDPLGPLAAHAVRVLDTGDTAGFRALLDPTVELSRHLFRPPTRFYKTGVVFLAWLAGHQDHFTMAGGLQSARSLPHLAKAYELADGLGLFPDPDLAAHRMRALLTVNGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7H4</accession>
    <name>A0A7K2Z7H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000141">
        <property type="protein sequence ID" value="MYW28268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7746" checksum="6C3D67C1FE36C142" modified="2021-04-07" version="1" fragment="single">MAEARAGLSAARELAAHHRAQVTELAALQDAPPTVDRGLRGRLQQLLQSSAERQAAQRRLDHGRAEIARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7L4</accession>
    <name>A0A7K2Z7L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13530" checksum="1DAF915C7353C941" modified="2021-04-07" version="1">MGQSTDAILAYGFILPDDAQEDVDWLDEESPDCEGFEYEAEKKLKAAGIAGVHVTSHCSVDYPMYLLAASTTTAWRGGPKVVDPHAMAAHPEAGDWDAKLREGMELLGLTSEMVAPGWILCSDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7R8</accession>
    <name>A0A7K2Z7R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnA</name>
        <name evidence="3" type="ORF">GT040_03705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000154">
        <property type="protein sequence ID" value="MYW28399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="293" mass="30082" checksum="010FF82E378E1A1B" modified="2021-04-07" version="1">AEAAGLLEGARPTAVNLGYGVRRVATAYWAAAEKGAGVAEAAAVALAEARALHREDARASERMAEYGTALLEELLPGQGYQLLTHCNTGALVSGGEGTAFAVALRVHRQGRLRRLWVDETRPLLQGARLTAYEAARSGMAYSLLTDSAAGSLFAAGEVDAVLIGADRIAADGSVANKVGSYPLAVLAKYHHVPFIVVAPTTTVDMETAEGTSIIVEQRSGQEVTEVTSLGGVSEGAGGGKVVAPLGAPVYNPAFDITPSELITAIITEEGVISPVTGVGLAELCARSSQVTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7X9</accession>
    <name>A0A7K2Z7X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA polymerase III subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_03995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000173">
        <property type="protein sequence ID" value="MYW28457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="9">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="12915" checksum="F4AA6C33E14B2157" modified="2021-04-07" version="1" fragment="single">MEFRIERSALAEAVSWAARVLPVRSPVPVLGGLLLDTEGGRLRVSGLDYEASARIDVEAAEVLRPGKVLVMGRRLLDICKVLPDGPVECAVEGSRFTVSGDGARFGLSVLPLDDYPALPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Z9</accession>
    <name>A0A7K2Z7Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000174">
        <property type="protein sequence ID" value="MYW28461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="9697" checksum="70BD3A77E25951F1" modified="2021-04-07" version="1">MTQLEIIRVSRLTGSLVPMSVWIDSQQVGTLGSGGSLKHIVTPGVHRVACGLDQAGSKAGAEEFDVSAGRRLVIVVSLSKWNGKPSFSAEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z851</accession>
    <name>A0A7K2Z851_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000190">
        <property type="protein sequence ID" value="MYW28488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="12535" checksum="13E32BEDCE7C096B" modified="2021-04-07" version="1" fragment="single">MRALEAPEEAEPTGTADPAGGPEDAVPADAVPGTEAEAPEDAPATQTPTDPRATVATSNETPGTGTGTGTGTGTTNAAPGPATGTNTGDIGEDRGTTRFLNTGPKPPQSDRATTHLALPQGLPPAPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z872</accession>
    <name>A0A7K2Z872_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_04510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000200">
        <property type="protein sequence ID" value="MYW28550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="981" mass="104964" checksum="7FDCA4E386F9CBE6" modified="2021-04-07" version="1">MPLLEPDPEALRPGTARAPAPDRVTDGSAAGTPEPLRSELTALLGAGKVLWKISDLVRYASDASPYRFLPRVVLVPEDLDDVSAILSYAHGKGREVVFRAAGTSLNGQAQGEDILVDVRRHWTGIDVLDDGARARIRPGTTVLRANAALARYGRLLGPDPASAIACTVGGVVANNASGMTAGTTRNSYRTLASLTFVLPSGTVVDTADPAADEELAHAEPQLCAGLLALKAEIEADEELTARIRAKYAIKNTNGYRLDSFLDGATPVQILRGLMVGSEGTFGFISETVFDTLPLNRRITSALLFFPSLTAAAAAVPRFNQAGAIAVELMDGNTLRASVSVKGVPADWAALPRETAALLVEFRAPDEAGQEAFEEAAAEVTRGLDLVVPAASVTNTFTRDAGTIAGYWKARKAFVTAVGGSRPSGTTLITEDFAVPPDRLADACEALLELQSRHGFDAAVAGHAAHGNLHFLLAFDAARPDDVERYDAFMQEFCALVVDRFDGSLKAEHATGRNIAPFLEREWGPRATELMWRTKQVIDPEGVLAPRIVLDRDPRAHLRGLKTIPKVEAVADPCIECGFCEPTCPSEDLTTTPRQRIVLRREMMRQADGSPVEAGLLDAYGYDAVDTCAGDSTCKLACPVGIDTGAMMKGFRHLRHTPREERIAALTAKNFRVVEASARLAVAAGNAIGERGGDRLLESLTRLARRAVRPDLVPEWLPQLPGRAARELPRTAKVGASAVYYPACVNRIFAGPEGPPGISLAEALVAVSERAGKPVWIPEDVAGTCCATIWHSKGYDAGNRIMANRIVEAAWGWTAGGTLPLVVDASSCTLGIAEEVVPYLTEDNRALHRELTVVDSLVWAADELLPELTVSRRTGSAVVHPTCSMEHLGDTEQLRMLAEACADEVTVPDDAGCCAFAGDRGMLHKELTDSATAKEAAEVNSRTYDAYLSANRMCEIGMERATGHPYRSALIELERATRPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8B0</accession>
    <name>A0A7K2Z8B0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">nucS</name>
        <name evidence="3" type="ORF">GT040_04735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000207">
        <property type="protein sequence ID" value="MYW28590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="24570" checksum="B87E32932BDC8355" modified="2021-04-07" version="1">MRLVIARCSVDYAGRLTAHLPSAPRLILVKADGSVSIHADDRAYKPLNWMSPPCTLKEGTGEETGVWTVVNKAGEKLIITMEEILHDSSYELGVDPGLIKDGVEAHLQELLADRIEILGEGHTLIRREYPTAIGPVDILCRDANGGTVAVELKRRGDIDGVEQLTRYLELLNRDPHLAPVRGVFAAQEIKPQARVLATDRGIGCLVLDYDAMRGIEDDKLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8J0</accession>
    <name>A0A7K2Z8J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_04985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000219">
        <property type="protein sequence ID" value="MYW28638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="194"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="486" mass="52715" checksum="7AA5C1E1B4655E15" modified="2021-04-07" version="1">MDADVTDSAGTPADPDLPAGDTPQGRSQEEPGAPDPKEEPEPGAVPENDAPQDSGDEGKADADEGKADAGEDSEGGGRDGDQHGSDGKSAAGAQTWADHPKDGSASRRKRPWMRWAALGASFLVMISAGVGWWLYKKLDGNITTDTSAAAELKVYEKERPTPVAMDAQNILLIGSDSRSGDNRKYGRDDGGSQRSDTTILLHLAADRKSATAVSLPRDLMVEVPKCRTGDDKETREQFTQFNSAFEVGGTACTIRTVERLTGIRIDHHMVVDFNGFKDMVDAVDGVEICLKKPIDDKDARLELPAGRQTLNGEEALGYVRARKTLGDGSDTERMERQQKFLGALVNKMQSNGVLLNPTRLYPVLDAATKSLTTDPGLDSLRDLYDLVRSMRDVPTDQVQFLTVPRQPYRQNVNRDELVEPDASELFKQLREDKPVAVVPADELKKKEGEKEKAQDEKPDDAGSDSESPTPTPTYSGSSAADDLCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z915</accession>
    <name>A0A7K2Z915_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000265">
        <property type="protein sequence ID" value="MYW28850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="24364" checksum="C6C8052B85DC7882" modified="2021-04-07" version="1">PVPPPGPPTLPGSPAGERPVVLLHGFIDNRSVFVLLRRALARHGRRHLASLNYSPLTRDPRTAAELLGRHVEEICARTGQREVDIVGHSLGGLIARYYVQRLGGDHRVRTLVTLGTPHGGTAVAPGAGLHPIVRQMRGGSPLIEELRLPAPGCRTRFVSFWSELDQVMVPVVTACVDHPDLDAVNVRVTGIGHLALPVHPAVAAAVREALESQEAREGTAPSTGTSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z930</accession>
    <name>A0A7K2Z930_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000267">
        <property type="protein sequence ID" value="MYW28854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="15693" checksum="7E9C7318FE0C393C" modified="2021-04-07" version="1" fragment="single">MHTDLVAALDIGGTKIAGALVDGGGNLLVRALRPTPAREGAEAVMGAVDEVLGELTASVLWERAGSAGIGSAGPVDAAAGTVSPVNVPGWRDFPLVERVQKTIGGLPVALVGDGVAMTAAEHWLGAARGYDNALCLVVSTGVGGGLVLGGTLHPGPSGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9U5</accession>
    <name>A0A7K2Z9U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal phosphate-dependent aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000355">
        <property type="protein sequence ID" value="MYW29127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="388" mass="42260" checksum="68474D46053830A0" modified="2021-04-07" version="1">MTQGRPLLNRRLAGFGTTIFAEMSALAARTGSINLGQGFPDTDGPEEIREAAVRALRAGHGNQYPPGPGIPELRTAVADHQKRFYGLTWSPDTEVLVTAGATEAIAASLLALVEPGDEVIAFEPYYDSYAACIAMAGGVRVPLTLRAPAFRPDLDELRAKITPRTRLLLLNSPHNPTGTVLTPEELSGIAALAVEHDLLVVTDEVYEHLVFEGSHHPIAALPGMRERTVSISSAGKTYSYTGWKIGWVTGDAPLVTAVRSAKQYLTFVSGGPLQYAIAEALQLPDTFFTEFRASMHRKRDLLAEGLRSAGFRVYEPEGTYFVTTDISPFGEEDAYAFCRALPERCGVAAVPVSVFYDDPEAGRGQVRFTFCKREDVLEEAVERLRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Y2</accession>
    <name>A0A7K2Z9Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000359">
        <property type="protein sequence ID" value="MYW29181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="11799" checksum="0480D9B42A6AE790" modified="2021-04-07" version="1">GLRPGPRSSNAGGAEVVTPVPALRVDVVAAVGAGDAFAAGFLSATLRGLPVRDRVRHGHLMAAAVLTVPGDLTEPPARDHADRLVALDDEAWGRLRLGPGWTAADRAPEEVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAS2</accession>
    <name>A0A7K2ZAS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="19" type="ORF">GT040_09215</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="WWKE01000418">
        <property type="protein sequence ID" value="MYW29450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MYW29450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="32026" checksum="A6CD82B26DDCC86F" modified="2021-04-07" version="1">MPELPEVEVVRRGLERWVSGRTVTDVEVLHPRSVRRHLAGGVDFAARLRGVRFGTAMRRGKYLWVPIDEAASSLLGHLGMSGQLLVQPADAPDEKHLRIRLRFDDALGTELRFVDQRTFGGLSLHDLTPDGLPDTIAHIARDPLDPLFDDAAFHTALRQRRTTVKRALLDQSLISGVGNIYADEALWRAKLHYDRPTATLTRPKSAELLGHARDVMNAALAQGGTSFDSLYVNVNGESGYFDRSLDAYGREGEPCRRCGTPMRRRAWMNRSSYFCPRCQRPPRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB25</accession>
    <name>A0A7K2ZB25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4132 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000452">
        <property type="protein sequence ID" value="MYW29556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025406">
        <property type="entry name" value="DUF4132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13569">
        <property type="entry name" value="DUF4132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4132" evidence="1">
        <location>
            <begin position="25"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="31179" checksum="20DC128A4C00B7E4" modified="2021-04-07" version="1">MGWVPAGDYEVALEAGKVVCRNGKGRRLKSVPAKLKEDPAVVGLRQLTEWLERHEGRCLTDVEQWMVRSLPVPTAVLAQVWPDPAWRAALRDVVVTGADGGVAGFLRDVDPGRGLGLVDLDGDTVRIAPDVVSLPHPVLLDDLDDLREFAVELGVSQRVEQLFREVWRRPPSLAPDTVSVDTYAGGVFKELRFLHGRVTQLGYRSRGGYAVCPVVEDGATVEARIWIGEHDGYDEYGTETGPLGWTDPSGRALTAAEVGPVAWSEGMRMAAALYAGRDVEDEERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB47</accession>
    <name>A0A7K2ZB47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000458">
        <property type="protein sequence ID" value="MYW29591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="212"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="507" mass="54034" checksum="424409F0995B9106" modified="2021-04-07" version="1">TRPERVADEAASRPVPRTMVAERKEVSVLIARVQLMPDAAGVDPQRMDEAVEQVAATIRGEAECLGGTVAASIGPISLVLFGVPEAADDDAERAVHAALTIRDQLTRIADPGEPDGGCTRGVSVQVAVATGEALVRYQPDRSGVPPTVNGALLDECHTLLSDTRAGEIRVCDNTRRSTGFAVTYQHGSPSSGWTVGGFRQEYTALHAVPVIDREYDLDVLRGLLQRSRHQATPHLVTVLGEPGVGKTRFVMEFERRVAANADAVRLVVGRVRPGGGAHPLEALHDLLLACCGILQGDRVETMTAKLNATVRRLKASEEDCRWMLSCLAPLVDPAAAQAPPGEMLTAFREFLGAVAASTPLVLVFEDLHWADQALVDFVENLTASQAGLPIFVIVTAGPELLKRRPEWGEGSLNRLTITLEPISDAAIDRLLEFLMSTTEGGAKNSVGGLLEALLESGGREPDARRHQLRRILASGSASLRYERCSGGGGLSAAAPECTPRLSGHAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBF3</accession>
    <name>A0A7K2ZBF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000458">
        <property type="protein sequence ID" value="MYW29595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="209"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="31995" checksum="9EBBE9DADEBE27A5" modified="2021-04-07" version="1" fragment="single">MQACEVYETAIAYAVFGDAHLDLHDPWYDLRLCAVNESPGADAKGFSVRTPYGLDELVAADTVIVPSVPDAVVSHGEPLPAAFIEALREAAARGARVVSLCTGAFALAEAGLLDGRRATAHWTNTADLAKRYPKAEVDGSVLYVDEGQVLTSAGMSAGLDLCLHLVRRDLGAHVANQLARRLVVSGHRPGGQAQFVDLSVPATEDDSLGPVMDWAAHHLDQALTVDGMAQRAGMSTRTFFRRLQAATGMTPLKWLLNQRLSRAQALLETTDLPIERISEHSGLGTAANMRRHFTLHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBG7</accession>
    <name>A0A7K2ZBG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000472">
        <property type="protein sequence ID" value="MYW29662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="26173" checksum="E0C610D31A2F7FA7" modified="2021-04-07" version="1">MSTTSTTTPSAEFVGRTALVTGGASGIGLAVARLLATAGAAVVVADYDEESARKAAAQLESTGARAAAVRMDVTDPASVEAGVRFTVETFGALHLAVNNAGIAGPAAPTGAYPVEDWDRVVATNLSGVFYSMRHELPAIVASGGGAVVNMSSILGTNGFAGSPAYVAAKHGVVGLTKTAALEYAAQNVRINAVGPGFIDTPLLRNADPQAREHLISLHPAGRLGTAEEVAELTVFLLSDKASFIHGSYHLVDGGYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBN5</accession>
    <name>A0A7K2ZBN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000492">
        <property type="protein sequence ID" value="MYW29754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="48"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="18789" checksum="A2EB787DC1B54B59" modified="2021-04-07" version="1">MRAPIGTFEDASPASERLDLLPAPVVAALAAGWGDVTADRIIHVDSDPAVADTAVFVEHYGADLLDTSANCVVVAGKRGGEVTLAACVVLSRTRVDVNGAVRKHLGARKASFAAMDTAVGETGMEYGGITPIGLPASWPLLLDPSVVDQEWVLIGSGSRRGKLIVPGKALAALPGAVVVEGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCE9</accession>
    <name>A0A7K2ZCE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_12275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000562">
        <property type="protein sequence ID" value="MYW30037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="26403" checksum="A74E3C4F710A89FB" modified="2021-04-07" version="1">MPRKRPGPTTDGNGSTRAGGHDRNRTHPRLTAVRHWIATAPGTYIWLTVLFVTTVVLHRMSPAFEDEFLRDRSTNLHELSQNPVRVLISSAFWIDGGRWLPYAVLFTLFHATAEHWLGTLRWLAVATAAHVVATLVSEGVLAWAIRQDHAPQSAADARDIGVSYALAGVIAVLSYRVPRPWPYVYAFAVLVFYGIPLLADGRTFTDVGHFTAVLTGLACYPLARSRRKTQKTEHPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCG8</accession>
    <name>A0A7K2ZCG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dapA</name>
        <name evidence="11" type="ORF">GT040_12080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="WWKE01000554">
        <property type="protein sequence ID" value="MYW29998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW29998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="31300" checksum="A048BD17DD231638" modified="2021-04-07" version="1">MAPISTPQTPFGRVLTAMVTPFTADGALDLDGAQRLATHLVDAGNDGLIVNGTTGESPTTSDAEKDQLVRAVLEAVGDRAHVVAGIGTNDTRHSVDLARTAERTGAHGLLAVTPYYNKPPQEGLLRHFTAIADSTGLPVMLYDIPGRSGVPIDTETLVRLADHPRIVANKDAKGDLGRASWAIAQSGLAWYSGDDMLNLPLLSVGAVGFVSVVGHVVTPDLRALVEAHLGGDVQKATEIHQKLLPVFTGMFRTQGVITTKAALTLQGLPAGPLRLPLVELTAQETAQLKIDLAAGGVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCP0</accession>
    <name>A0A7K2ZCP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000598">
        <property type="protein sequence ID" value="MYW30127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="262"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="475" mass="50096" checksum="5D13009D95611018" modified="2021-04-07" version="1">MPNLNAGETGGAVGDVGAVGAAGAVEDVKAAWGVRLRAAVRRAPRVLYEDLWAAPADRVPRMGEVGAPVWRPVFLVMLVMIAVGVTVIRTFELSPHGDSVNKPTVLLAIAQSAVLVAGMGRPVGAWWAATALTVVSVLVVVAEAPSELPYPLVSMVPLSPQVLYPSPFAGAALQGGALFLLALRVRPRRAVVALVLSMALALFLALRTPPVPHIGLAASVLVFSTALVLGTALRSLRLARQDLVDQVELTADERARRTLLEERHRIARELHDVVAHHMSVISIQAQVAPHLVRDPSDELKENLTGIRENALEALAELRRVLGVLRSEEAPSQSTRHTPQPSLDRLGALVASVRSAGMAVTLATTGERRPLPPGVELSAYRIVQEALSNVMRHAPGASARVEIGHQAAGLTVRVTNTAPLRPSLAPLASHGVRHGLLGMRERTTMLGGDLATGPAPGGGWEVIAILPVTGDTEDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCT2</accession>
    <name>A0A7K2ZCT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1266 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000598">
        <property type="protein sequence ID" value="MYW30129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009677">
        <property type="entry name" value="DUF1266"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06889">
        <property type="entry name" value="DUF1266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="383" mass="42460" checksum="47780197DF294D76" modified="2021-04-07" version="1">MYPPPVPPTGIERALEAAVASGDGGAVVEVLARTRLYVLVARLHADIPGWTAPLPTIRDEASRRTCVPVLTPGMLPPWHPEWVFREVNLGELARTWPYDVRRLAVNHGTPYAAMVEARPKHLKAWLRADEHSGGPEHGVLLTDSGGPLSGPLAHGLALGTHLAVTNGLIWNRLGAVYEDYATDRARLRSPWGIPHRAEYRDRLASLMKNQLVGRVQEAVLRTRHVLATRLGRTPTREEWAEAVARTFAARDADDRALADRSLHYIALYENRLRADGVLAPDGRVDTLAAFDLGRAVNVVRLALGARYGDPHEAEQDVLRLGELARGAYPSWPDFSLGYLMARIVHRAEDDGPEAAEHTYRQSLAEHRILTQDPTSPYRNIPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD05</accession>
    <name>A0A7K2ZD05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage holin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000606">
        <property type="protein sequence ID" value="MYW30188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="18220" checksum="31294FEA2DDD91A7" modified="2021-04-07" version="1">MSDPGNYVGSADRSIGQLVAAATAEMSALVHDEIALAKAEVRQDVKRGAIGSAAFIAAGVLLLFTMPMLSFAAAYGIHNLGLGLAWSFLIVAGAFILLAALIGFIGLRKFKKIKPPEKSIASAKQTAAVLQKAKPHPRPAVEADAILRRSGSSLAAGTGVEALPAGKDKASAVARSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDN2</accession>
    <name>A0A7K2ZDN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_14525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000676">
        <property type="protein sequence ID" value="MYW30464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="9971" checksum="91CE6779FCA7878B" modified="2021-04-07" version="1">RADAGRHPSPNAGPVEAAFAGALGVRLGGTLAYAGRVEHRPVLNGESGREVQSSDIERAVRLSRRVSVLALGVCVVGRMAVGVVAGRSSTGQRRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDV2</accession>
    <name>A0A7K2ZDV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_14905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000713">
        <property type="protein sequence ID" value="MYW30537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="391" mass="44212" checksum="7C5197CC233213FE" modified="2021-04-07" version="1">MRTEQLVRTFVEFYEERGHRRITGSTLLSPPGDPVLFTTSGMHPLTPYLEGRPHPLGRRLVNVQRCLRTTDLDEVGDATHLTVFEMLGTWSLGDYEGPAGLEWGYELLTEGLGVDSGLLHATVFGGDERTGPDTASRELWQGLGVPVEATVEDNWWSNGPVGPCGPDSEIFLWSGEGPPQSTPTRDDRWVEVWNHVTMTHRRLGDGSLVPLPQRNVDTGLGMERLASLLQGKPSVFACDLFEPWRRLVPAVWELDEPSLRLVCDHLRSAVVILGDGVRPANTGRGHVLRRLVRRVLTVLRRDDPSRGVGDLPEELVRHTLDHFRQDTREMCPEYVLRMLREEEDRFGRLLEHGRQVLARARFQGPLSEEDFHYLHDTHGLPRELITSLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE32</accession>
    <name>A0A7K2ZE32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000720">
        <property type="protein sequence ID" value="MYW30610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="20131" checksum="52ABB1697A4CAF13" modified="2021-04-07" version="1">MTQTIGALLEAAAGRALPVVRGIDDGQLGRRTPCEEYDVRALLNHLFLVVVNFQALAAREEVDFGHQPEFVTGDWRAGFGAETARLVEAWSVPGAEEGTTGQMGLPARTVGLMVLGDLTVHAWDLARATGAEFVPDPGVVEEVGPGLAALAPQAREMKVFGEPFPVGEGATAFERVLAVTGRDPGWSGPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEJ3</accession>
    <name>A0A7K2ZEJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000758">
        <property type="protein sequence ID" value="MYW30771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="24351" checksum="234496898A0FB2C4" modified="2021-04-07" version="1">MGWTYGLIASDPAVRGVALVRLADAERNTRDALDRYNRTWRRRYSLRRKAAHRNYEEIRKHSLPDVLWDRPAGPDIVAWPGLPYALLFLEWEARYPQEWTRHAKAWGTKQGLIRDVAVAHHDETVRAKLADLIEIVVQRPYRCKDREYVRAARAVDGDDLRTRLQTAARSDNPWARRHAGYILWLLDRPEVPNTRHVWRTWLAAASGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEU0</accession>
    <name>A0A7K2ZEU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="605" mass="65394" checksum="0E913C3DFCF5FFA2" modified="2021-04-07" version="1">MASRARVRAPELIGKGGWLNTGDRQYTLSELRGRIVILDFWTFCCVNCLHVLDELRELEEKHRDTVVIIGVHSPKFVHEAEHQAVVDAVERYEVHHPVLDDPELATWKQYAVRAWPTLVVIDPEGYVVAQHAGEGHAHAIEKLVEELEAEHGAKGTLRRGDGPYVAPEPVATHLRFPGKALLLPDGGFLVSDTTRHRLVELEADGETVRRHFGTGERGLHDGGPDEARFSEPQGLAVLPDGRVAVADTVNHAIRALDLTTGVTSTLAGTGRQWWQGTPTSGPAREVDLSSPWDLAWFAGRLWIAMAGVHQLWTYDPEAQAVRVAAGTTNEGLVDGPAAEAWFAQPSGLAVSADGERLWVADSETSALRWVDRDEHVHTAVGTGLFDFGHRDGAAAQALLQHPIGVTALPDGSVAISDTYNHALRRYDPATGEVTTLATDVREPSDAVLVDGDLVVVESARHRLTRLRLPEEAVRVAEQAHRTQRAATEIAPGTLRLDVVFQAPAGQKLDTRYGPSTRLLVSATPPELLAEGSGAGTDLGRDLVLADGVTEGVLHVSAMAASCDDDPANEYPACHVHQQDWGVPVRVTAEGTPRLPLVLAGMDEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF44</accession>
    <name>A0A7K2ZF44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000809">
        <property type="protein sequence ID" value="MYW30973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="365" mass="42184" checksum="0BD9BAFD7946AE37" modified="2021-04-07" version="1">MNLMTTPTPRRRSRLHRAASDIPYFSADGEAYLAQTALRELDKSRPLRVLSEEDFAHWQTYGYVIVREAVPAPVARRLLDFTWDFQGLDPERPESWYEDRPLRSELDQQLHIYGFVEAYHHQLLWDNRQSRRVYDAFVDVWDCEELWVTLDRLNLNPPNRGNRDRSLIEPTDRGFDIELHWDIDTTLAVPPQRVQGIIALNDTRPETGGFQCCPELFRQFDTWKVGQPGDRDPLRPTIDRDELPVVRPDLRPGDLLIWNGLLAHGVARNLSQSGVRAVQYLSMMPALEEHERLRKSRVESWRHLRTPRWNRTLVGDPVLPESKRYPTAELNPLGARLLGLASWQDPVEDTAPAAQSGELSCDASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF77</accession>
    <name>A0A7K2ZF77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_17295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000811">
        <property type="protein sequence ID" value="MYW30986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="35636" checksum="EE95E21A0835489F" modified="2021-04-07" version="1">MTLTTPHTVPAPALRDHRIPADGLYEGPRELRRVPEGWTDRPYELFELVPRGRVIGAEIHGVDLSRPLGTAVRAELDRALLEWKVLFFREQHLTSLQQRAFAGHWGELETNPLLATGDDPEVARLDRSAVPTFENVWHADVTFRERPALGAVLQLREVPPVGGDTMWADMAAAYDNLPEEVKERIEGARAVHDFIPGFSRFYPPERLAPHQDRFPPVEHPVVRRHPATGRRTIFVNASFTTRIVGFAREESDRLLRLLFQQAHAPEFQVRYSWRAGDVAFWDNRATQHYAVNDYAPHRRVAERVAIAGDRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFC6</accession>
    <name>A0A7K2ZFC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_17675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000828">
        <property type="protein sequence ID" value="MYW31061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="71"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="5">
        <location>
            <begin position="326"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="390" mass="41354" checksum="44A995F7ADC89743" modified="2021-04-07" version="1" fragment="single">MTTDQTASTPAADASATPLTLAEKASLTSGGGDFVTSAVDRAGVPAVTLSDGPHGLRLPKEAGDGGQLDLHSAAPATCYPPAVALGSSWDPELAHRVAAALADEATAHGVRVLLGPGINIKRSPLCGRNFEYFSEDPLLTAELGGAMVRGLQESGVGAALKHYAANNQETDRMRVSADIDERPLREIYLRAFERIVRRDRPWSVMSAYNGVNGVTLSENTRLLTDILRTEWGFDGIVMSDWGAVRDRVAALRAGLDLQMPGTRGRTDAEVVAAVRDGSLDESVLDTAVERLVRFARRATAGDGRPEPRMSVDDHHRLAGEAAERCVVLLKNEDGLLPLSPDAGSVAVIGEPARTPRYQGAGSSQVTPTRLDVPLDALRDRAEGARVAFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFI0</accession>
    <name>A0A7K2ZFI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000855">
        <property type="protein sequence ID" value="MYW31113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10634" checksum="7CFD8234F0779709" modified="2021-04-07" version="1">MVHDGVGGVPIERSLVVYPVLKHALRHLRFVKSQQPSDGDSVEFADWRERIAEALDALAGVLVFEDDRARARAEATAAREQAAEVRRRGEIGASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFX5</accession>
    <name>A0A7K2ZFX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000862">
        <property type="protein sequence ID" value="MYW31195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="12551" checksum="C7188A39B195FA57" modified="2021-04-07" version="1" fragment="single">MADTVTDRPGYGQLLRTPGAWTFLLPGFAARQPFAMLTIGIVLLVQHTTGSYGTAGAVAAVAGVSMALVAPQGGKLADRFGQRAVLLPGVLLHTASVGALTALALADAPLWALFAAAVPTGASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFY3</accession>
    <name>A0A7K2ZFY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000863">
        <property type="protein sequence ID" value="MYW31199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="435" mass="47209" checksum="53743E6131C4EF99" modified="2021-04-07" version="1">MTPLDLAGYLIAGLMTAVALWRMPAALWGDEEDRRRRALWGCYAGFAIALWTKTEAVRTGLNNSAVTDLAVLIKHYTATVAILAILSYIVAIYGSYPEAGTVPRHVRFARLVQQVAAKASVATLILLTVLFFTVVDRSVPSDRFVSDHAGEWGATLYMSVFYLYLGAASAVCAFQWALATADAQRRHLRIGLGMMTFAMFIGVGYTVSRTLFLWVSVVDEPSEAFALRFDQVTEAAQLVLFAFFALGASVPAFSTGARRVRLWRAQVRLHALWYELMASFPDQPFDPPASLTRELTRFNAPADLRIDRWAADIADAVEKLRHYVPDELVAASEEAAARDAADTGRAAALGDAYWIRAALLAKESGAPAGPAAAVAAQQAADQDGEVARLERVAAAYKTVTAERAREVLGAATTRTAETTRTSATARTSETTEQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG01</accession>
    <name>A0A7K2ZG01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidase</fullName>
            <ecNumber evidence="1">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000871">
        <property type="protein sequence ID" value="MYW31256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7332" checksum="9A13F5AB457102E1" modified="2021-04-07" version="1" fragment="single">MEWNFESAENLVRALRAGDVTSAELTDAAIARIERDDQAINAICVPDFDRARAAARDADRARARGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG27</accession>
    <name>A0A7K2ZG27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000869">
        <property type="protein sequence ID" value="MYW31245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="35828" checksum="4953EEABE435508E" modified="2021-04-07" version="1">MPQPPTDPATPPGAVHRLVDTPGGRIHLVEQGTGPLVLLVHGFPESWYSWRHQLPALAAAGYRAAAIDVRGYGRSAKPAATDAYRMLAHVADNTAVVHALGEETATVVGHDWGSPIAANSALLRPDVFTAVGLLSVPYAPRGENRPTDGFARIGGDEEFYVSYFQAPGRAEAEIEQDVRGWLAGFYTGLTGGALTIEEHGRLFFVPPRAHLADRFPTGPLPAWLTEADLDVYSGEFERSGLTGALNRYRNVDRDWEDLAAWHGAPITQPSLFIGGSLDASTTWMADAIDAYPATLPGLSAAHILEGCGHWIQQERPDEVNRLLTQWLDGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG61</accession>
    <name>A0A7K2ZG61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_18870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000876">
        <property type="protein sequence ID" value="MYW31279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515783.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000876.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="519" mass="53617" checksum="57A15A5FE6613FF5" modified="2021-04-07" version="1">MAKTADTPLSRIAGTGLPDPSRWKALAFIALAQLMVVLDATIVNIALPSAQTDLGISEGNKQWVITAYALAFGGLLLFGGRIADLWGRKRTFVVGLIGFALASALGGAAQNEAMMFGSRALQGVFGALLAPAALSLLAVMFTDAKERAKAFGIYGAIAGGGGAVGLILGGFLTEYLNWRWTFFVNIPFAVVAAVGAYFVIREPSGTRNRSPLDIPGVVLSTLGLVALVYGFTRAESAGWSDGLTITMFIAAAGLLLAFVVVESRVKSPLLPLRVLTERNRGGVYLSLGLAIIAMFGLFLFLTYYLQIVKGYSPVRTGFAFLPMIAGMITGSTQIGTRLMTRVPPRLLMGPGFLVAAIGMLLLTQLDLNTSYAAVILPGMLLLGLGMGTAFMPAMSLATHGIEPRDAGVASAMVNTSQQVGGAIGTALLNTIAAGATTAYIADNAARATDPKLLELQAMVSGFASAIWWAVGILVLASAIAVVLINTGRPGTGAAGGTGGASGGNAEGAEDEFRIPVVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGF4</accession>
    <name>A0A7K2ZGF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_19725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000919">
        <property type="protein sequence ID" value="MYW31443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="249" mass="25105" checksum="99FE6A7DF780E63E" modified="2021-04-07" version="1">TRNPLGSPDVIGFTTGSYTGVVLTLLAGASSYSALAAGALGGGLITAFAVYLLAFRRGVRGFRLIIVGIAVGALLSSVNTWFLVKADVDTALRAAVWGAGSLSAIGWPAVTMAAVLTAVVATAAPVAQRRMRWLELGDDTAAMLGVPVERTKLLLVVLGVAATAAVTAAAGPIAFVALAAPQIARRLTGRGTVDLTGAALVGALLLLGADLVAQHAIPGVSLPTGAVTVCVGGAYLLVLLVRESRREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGI3</accession>
    <name>A0A7K2ZGI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000913">
        <property type="protein sequence ID" value="MYW31415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="48"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="180" mass="18997" checksum="F768104B9249D2CA" modified="2021-04-07" version="1">MSGVSGKRATAATETDGRPGDPPAQPTQPAPRGFGLNGNGYGSLSRQFPSTPQGAHEARHAVVRQLGHWGFGPMTDVSCTVALVVAELAANAVRHGSLPGREFAVRVDHEGVASRFRIEVSDARLGRTPEEAVLPPGDRESGRGLFLVECLATRWGWEPRHPIGKTVWAEVAAPGRPGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGK6</accession>
    <name>A0A7K2ZGK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000914">
        <property type="protein sequence ID" value="MYW31419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="127" mass="13565" checksum="08EB63A882885199" modified="2021-04-07" version="1">ERVPELAAAASPAEQSELLHDRLGGLARAEHVPAPPPARAVRTGSENKARLWTRAAIAFAALLIGATALTLHTAPTHYEQPLSPPERVGGVPPRGGPQKLTPQDIRLQKSLNEQLAHGPERLVPRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH20</accession>
    <name>A0A7K2ZH20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GT040_20585</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="WWKE01000971">
        <property type="protein sequence ID" value="MYW31608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="30"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW31608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="356" mass="37075" checksum="4EFDE635BA577A7C" modified="2021-04-07" version="1">MTSKGTHQWRGIIEEYRDRLPVTATTPVVTLREGGTPLVPAQVLSERTGCEVHLKVEGANPTGSFKDRGMTMAITRAKEEGAKAVICASTGNTSASAAAYAVRAGMVCAVLVPQGKIALGKMGQALVHGAKILQVDGNFDDCLTLARSLSDNYPVALVNSVNPVRIEGQKTAAFEIVDALGDAPDIHVLPVGNAGNITAYWKGYTEYAGDGVSTHTPRMWGFQASGSAPIVRGEVVKDPSTIATAIRIGNPASWDFALAARDESGGFIDEVTDRQILSAYRLLASQEGVFVEPASAASVAGLLKAAEEGKVDPGQRIVCTVTGNGLKDPDWAVAGAPQPVTVPVDAATAAQKLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHF0</accession>
    <name>A0A7K2ZHF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GT040_21500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW31782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="503" mass="56491" checksum="83DC661E1DA0B0DB" modified="2021-04-07" version="1">MDLALAPETLARWQFGITTVYHFLFVPLTISLAALTAGLQTAWVRTDNEKYLRATKFWGKLFLINIAMGVVTGIVQEFQFGMNWSDYSRFVGDVFGAPLAFEALIAFFFESTFIGLWIFGWDRLPKKIHLACMWMVSLGTILSAYFILAANSWMQHPVGYRINEERGRAELTDFWKVLTQDTAVTQFFHTITAAFLVGGAFMVGIAAFHLARKKHIPVMRTSLRLGLVTVVIAGLLTAVSGDQLAKVMFRQQPMKMAAAEALWDGQERAPFSIFAYGDVSEGHNSVEISLPGVLSFLADNNPNSYVPGINDINKAQEEKYGPGDYRPNIPVAFWSFRWMIGFGMASFGLGVLGLWLTRRKFLLPPALRTGEDEVPNLVLFRNKVLSPKFTKLYWLTALWTLLFPLIANSWGWIFTEMGRQPWVVYGVLQTRDGVSPGVSQGEILTSMIFFTLLYAVLAVIEVKLLVKYIKAGPPELTESDLNPPTRINGHDDEDADRPMAFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHR0</accession>
    <name>A0A7K2ZHR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="6" type="ORF">GT040_21960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001032">
        <property type="protein sequence ID" value="MYW31867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q6" evidence="5">
        <location>
            <begin position="70"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="24506" checksum="35522857F92AF5F4" modified="2021-04-07" version="1">MGLTSRPTPAGQQPEPSAGPQAATGPEPVLLPEPKRLGILSRLAPEPMKVVLNWGRRYSLWVFNFGLACCAIEFIAASMARHDFIRLGVIPFAPGPRQADLMIVSGTVTDKMAPAVKRLYEQMPEPKYVISFGACSNCGGPYWDSYSVTKGVDQIIPVDVYVPGCPPRPEALLQGILKLQEKIARESLAERYGDGPSGGAPSTAALRSGLVTAPAPVAKAPGTEPGEEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI21</accession>
    <name>A0A7K2ZI21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001066">
        <property type="protein sequence ID" value="MYW32012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="304" mass="31506" checksum="F2D2A08D85DED032" modified="2021-04-07" version="1" fragment="single">MTSTDAATEGHEAAALLERTRRLVDPHLRSAVESLPGGIRRIAMYHFGWENADGTPAAGQAGKAIRPALVLAAARALGGDSELAVRAAVAVELAHNFTLLHDDVIDEDTTRRHRPTAWAVFGVPDAIITGDAMLALAQRLLVEDTHPAAQRASARLSSCVIELCAGQQADCAFEERGPDEVTLDECLTMATAKTGALLGCACALGALYAGAGDRAVRAMDGFGREAGLSFQLIDDLIGIWGDPARTGKPVGADLAAHKKSLPVVAALTSGTPAAAELAALYRGPMTTAAEVDRAADAVDRAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI45</accession>
    <name>A0A7K2ZI45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4240 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001069">
        <property type="protein sequence ID" value="MYW32032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025334">
        <property type="entry name" value="DUF4240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14024">
        <property type="entry name" value="DUF4240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4240" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="190" mass="20176" checksum="033DD42483DB4DCA" modified="2021-04-07" version="1">MDIDTWWGLVGRAREAAGDRADDRDPPDDPLPGALTDVLAALGPAEIVDFAVTAYEVTASAYRWPLWNAAYLIEGGCGDDGFMDFRDGLVLLGREVFTRAVADPDSLAGLPVVVRMSRGRSGWIGYESLNVPVQAAYARAGGAADGFHAAVEVAGRGRIRSGEPGGENGDAEDADAMRRQLPRLAALFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI63</accession>
    <name>A0A7K2ZI63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001072">
        <property type="protein sequence ID" value="MYW32050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="10336" checksum="4E364689510F0A5E" modified="2021-04-07" version="1">MTLEFLGKDPDSPNGGSPTVWLEEEAAEIVVQGWLPDLEMYAKINETEWVPGHPAGVPDHEAVVRIPVRMIPILRKACDAAERAGLHRPVEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI98</accession>
    <name>A0A7K2ZI98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_22980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001074">
        <property type="protein sequence ID" value="MYW32058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1186" mass="126502" checksum="079BC6C22E53B7D6" modified="2021-04-07" version="1" fragment="single">PLVPTAWATVERLPLTPNGKLDVAALPPALPVASDGGTPRTAQEARMCAVFAACLDVPRVGRDDDFFALGGHSLLAMRLIGRIRGEFGAEVPISTLFSAPSPVGLVAALGEVAPARRPVTAAVPRPERLPLSFGQQRLWLLETLGDAGASYHLPVALRLRGALDRDALELALHDIVRRHEALRTVVAETPDGPCQRILPPARLPRPLLRVMAAGEPVGRDAAPFDLSREIPLRARLFPLGAEESVLLVTLHHIAADGWSMGPLMRDLSAAYGARRAGRAPEWNQLPVQYADFALWQRELLGDPDAPDSLARRQLSSWAASLAGLPEESSFPADRPRPARSSGRGGSVPVRVGAQEHRALVKLAVDCGASSFMVLHAALAALMSRLGAGDDVAVGTPVAGRTDEALTELVGFFVNTLVLRADTSGAPAFRTLVERVARTDLAAYAHQDIPFERVVEELAPPRSLARHPLFQVMLSLNNTPAPRPHLDGLTVGHESSVGRSGSKFDLSWDLSEHHDDQGRPDGISGELEYDEDLFDRTTAERFAEHFTRLLSALLATPDRPVTDAGFLTPSQRAAALDEPPCTARKPLGATPGTETGTGARSAADDWTVLDVLATRAAVQPDRTAVVAGDTRLTFGELRLLSDRLAVALRDRGVGTGDRVAVALPRTSLAIVAVLGILRAGAVYVPLDPAQPAARTSLILDTAAPRLVLATSATRAALPDTADVLLLDGAEERSNDVATLPVPPRGHDAAYVLYTSGSTGLPKGVVVEHRSLAALLAHHRDRLMGPAEADNNGLPLRVAHTAAMTFDASLDPLLWMIAGHELHLVDDATRRDPEALTDLLHERAIDVVETTPSFVEQLRSCGLFAPGRPRPRVLALGGEALSGPLWRELAALSDVAVWNLYGPTETTVDSVMGRVLPGVRPHLGHPVTGARARVLDRRLEPVAPGVTGELYLSGPGVARGYENRSGATAERFLPDPYGAPGSRMYRTGDLVRRVEGRLEYLSRADGQIKIRGFRVETGEVAAALDAHSDIAQSAVTVRTHSGSGSDPDSEFGSGEAQLVAWVVPAGHRDLSPQELRSFVARRLPAHMVPSLIVPVTALPLTPHGKVDFAALPLTTTAGSTEAAGRAPRTAQEEILCALFAESLEREQVVPDDDFFELGGHSLLATRLIGRIRSAFGVELPVRALFEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIJ7</accession>
    <name>A0A7K2ZIJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="12109" checksum="FEEDCDAE9148FDB6" modified="2021-04-07" version="1">MSNEAVQPYQRIVQDVRDKIRSGRWTAGTKLPSTRELAEEYGVAAGTVQRALTELRTAGLIYSHQGRGSFITETASESSEDSTARALKALEEQVADLAARLERIEKGRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIK9</accession>
    <name>A0A7K2ZIK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001087">
        <property type="protein sequence ID" value="MYW32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="29258" checksum="C4E8D15896A67B82" modified="2021-04-07" version="1">QRPPTSPATTRASITDVVPRRTLAVIAGVVVLAILGTVLALTLGDGDDKANAGNGKGDTTASAGAAAGGSDGEGDSKGGDSEGGQKEGQGTEDGKVPGDPSGDPSGDDPKTDDPGTDDPETGDPADGSLPAGYKKVADDRFHFTMGMPDTFRRTAIAGTNSGGIYNTERGAFPRVQVDFNGSPKDDAAAAWSGAVASVRLLSDNYKHIGIKKVEYNGYPTVADWTFERSHNGVRVRVLNRGFKVDAQRGYSIMISCKVDEWDGDACRTLRETAFATFTPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIL2</accession>
    <name>A0A7K2ZIL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="22031" checksum="BE926E0CF86F97A4" modified="2021-04-07" version="1">MALTLFARRPEPVEAPAPEPWPEIGETWKPEGVTIAQRYYNQAHAVVLVYTTDDGPHGTYYSVACLGCHYATRENGKRTYSTRYSLADAATVANEHATTCRALPRDIPARPDDDTVRERLHAWVRGARRRDEDRQLWVSDLDLIRLTLQRSNDWIVDVLNQLVVAEPEILRIERSQYSDYVSYYARRLPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIT7</accession>
    <name>A0A7K2ZIT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001115">
        <property type="protein sequence ID" value="MYW32235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="239" mass="26146" checksum="B7933606D3F9B592" modified="2021-04-07" version="1">MPHAGGTASRYHRWTSLVPPSIEIVPLELNGRGDRMSHGFYASFAEALDDLTRRAVSVLEPGDSFAIFGHSMGAYIALELERRLESLGVRADRLFLSGRGTPAYHNVLSRPARELSDQELIAGLDAYGGLPQAVAGHELMRTLFLPIIRADFHLLEDGARSIDERVPVRSPLVILNGKDDAAAQQAPPGVWEALSVSGVEFHSFAGGHFFVDEHLQSIIQLIVEKSKKELEKDGVPFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIU9</accession>
    <name>A0A7K2ZIU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="17561" checksum="D9B2F49BF273C61F" modified="2021-04-07" version="1">MAADDAIALDGFLDEETVPGDLHGETARFRLTVSPTDERTDEMILPCSVADPALAHAVIHDLVPGDKLRVTGYLRLPRTPDEPMWLVVTTLAVLETAPELSDPTAVATAVIERYGPYVCWFDADTTGVEVFTEGGTWVGTAPEPNDLGELLEAFEHRQAAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIV8</accession>
    <name>A0A7K2ZIV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001123">
        <property type="protein sequence ID" value="MYW32267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029533768" evidence="2">
        <location>
            <begin position="23"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="681"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="814" mass="85744" checksum="EF916D2A409903CE" modified="2021-04-07" version="1" fragment="single">MGAVVLLAPLLVVGSAATPHGAADAVAAPSTADPAEAGRIAFAGTEHRSLGRVADPQNTAPLFGDGPTHYDQDPSARRGVLVFTSLRDSVRPQVYVRGADGTVRRLTTDRDAANPELSPDGRTVVFDSAEPGPDGTVQRDLWAVGVDGSGLRRLSDTPDNEESPTFSPDGTRIAYACDGDTSRGWQIYEEPLAGGERTRISDGPPGDAKDPSWNPVDDDTHRSRVAYTHITDPDPETGYRLRVTEGIGSDRPLLAGGHAEWGSHSVSWLPNGDDVLFLSPFHVCGCDDFDHVYRGPAFSEQTPQQLLTENRDVASPTWTGGDSDSGDVIVSRISSSAANVVTLQDVRQDGSDPRDLGFTILDEDPAARTNTDPAIDPLFNPATGYDPWTERQNYTPDGRRIVVTRFEGPDDARIQRIWMVDADGTNGFALPLAGRGERDWDTDPTFSPDGTKIAFTRTSPGGVGEAAGPGRILIADVASGAILDEVRPPEGQQQGGDAQPTWSSDGVNLAFTRTQVINGNGGNKHIWVVPVSSLGQQRDLSATICPGDCEVIDDSPAFSPDGTRVAFNRKDGGGRINERAGIIVKPLRGGGCRVVLPSSERDDPDGCDQEIPDTTGTGPFQPRDVAWSPDGSRIVLSSRREQAVNSMEQLSVLDLASGELTPLDNEHAGRQKEPSYQQSVDLAVTAPPTGPAVEVGSSVEVKVTVVNRGPSPSPGTVFTADPPPGVRLEELTTPAGSCGAGSPQCDLGVVPPGASVEITAKLTGVTRGDQPIGWSVTGTVLDPNPTDNATGTLVPVQDVPPPTPTPTPPTPTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJU1</accession>
    <name>A0A7K2ZJU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="11" type="ORF">GT040_25920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001204">
        <property type="protein sequence ID" value="MYW32616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="263"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="380"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW32616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="452" mass="46674" checksum="F1AB6B7777BB19C8" modified="2021-04-07" version="1">MGRLFGTDGVRGVANADLTAELALGLSVAAAHVLAEAGTFAGHRPTAVVGRDPRASGEFLEAAVVAGLASAGVDVLRVGVLPTPAVAYLTGSLGADIGVMLSASHNAMPDNGVKFFARGGHKLADELEDRIETVYEQHRTGEPWTRPTGAGVGRVTEYAEGFDRYVAHLIGVLPNRLDGLKVVLDEAHGAAARVSPEAFARAGAEVVTIGAAPDGLNINDGCGSTHLELLRAAVVEHGADLGIAHDGDADRCLAVDAAGEEVDGDQILAVLALAMREAGQLRKDTVVGTVMSNLGFKIAMEREGIQLVQTAVGDRYVLESMKAEGFALGGEQSGHVIVLDHATTGDGTLTGLMLAARVAATGRSLAELAGVMERMPQVLINVPDVDKSRVTTSSELATAVTEAERELGSTGRVLLRQSGTEPLVRVMVEAADIEQARAVAGRLADVVKSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJW8</accession>
    <name>A0A7K2ZJW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_26055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001210">
        <property type="protein sequence ID" value="MYW32642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="497" mass="52403" checksum="B609D167E1C9600B" modified="2021-04-07" version="1" fragment="single">MFDTVLVANRGEIAVRVIRTLRELGVRSVAVFSDADADARHVREADTAVRIGPPPAAESYLNVPALLEAARRTGAQAVHPGYGFLAENAEFAAACTDAGLVFIGPPASAISLMGDKIRAKETVAAYGVPVVPGSSGSGLTDAQLESAAREIGTPVLLKPSAGGGGKGMRLVRDAAVLAEEIAAARREARASFGDDTLLVERWIDRPRHIEIQVLADAHGNVIHLGERECSLQRRHQKIIEEAPSVLLDEETRAAMGEAAVQAARSCGYVGAGTVEFIVPGNDPASYYFMEMNTRLQVEHPVTELITGLDLVEWQLRVASGEQLPYAQADISLTGWAIEARVCAEDPSRGFLPSGGTVLALREPQGGGVRTDSGLSEGVPVGSLYDPMLSKVIAYGPDRATAIRKLRAALADTVILGVPTNAGFLRRLLAHPDVVSGNLDTGLVEREAEGLVPDGVPDEVYAAAAAVRREALAPRPDAGGWTDPFSVPSGWRTGGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK28</accession>
    <name>A0A7K2ZK28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMC-Scp complex subunit ScpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scpB</name>
        <name evidence="5" type="ORF">GT040_26330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001226">
        <property type="protein sequence ID" value="MYW32693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="23753" checksum="9340EE200D8FAB39" modified="2021-04-07" version="1">MSEQPIQGDGTGAVASLDLKPALEAVLMVVDEPATVDQLAKVLQRPRRAVADALRELADEYTVQRRGFDLRLVAGGWRFYTRPEYAAAVEGFVLDGQHARLTQAALETLAVVAYRQPVSRSRVSAVRGVNCDGVMRTLLQRGLVAEAGAEPETGAILYRTTNYFLERMGLRGLDELPELAPFLPEADAIEAETLEGVPSFDPDAPDTPDTHADDKTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK30</accession>
    <name>A0A7K2ZK30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Export associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001237">
        <property type="protein sequence ID" value="MYW32712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="239" mass="25635" checksum="5709832656A1B822" modified="2021-04-07" version="1" fragment="single">APPAQPGQAAQPVAGDATGWSMDERLYNQIWGMFEDLARAAAAYRSAVDFAESRMGQELDRSLSDPRNRIGGAADRAREEARAKRDELTARAREVLDRDLAQLAAEAAVVEPALPAAYAGWDNPVWHAHRIPMELPMALRLGDLHLPERTGLRIPLLVRLPLERGIWVDSGRTASEAAALMDSDRLRLLAMETAVLHAARLLAVYPPGEFSVHVIDPAGSAAGPLAPLVDAGVLAGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK38</accession>
    <name>A0A7K2ZK38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coagulation factor 5/8 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001235">
        <property type="protein sequence ID" value="MYW32710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="177" mass="19554" checksum="FA7BF5A46F73281E" modified="2021-04-07" version="1">IVVNSDDVIIDHTWVWRADHGEGVGWETNRADYGVRVYGDDVLATGLFVEHFNKYDVEWYGERGRTIFYQNEKAYDAPNQAAIQNGDTKGFAAYRVDDSVDVHEGWGLGSYCNYNVDPTIRQDHGFKAPVKPGVKFHSLLVVSLGGMGHYNHVINNTGASTVPAGTSTVPSMVVSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK50</accession>
    <name>A0A7K2ZK50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_26510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001247">
        <property type="protein sequence ID" value="MYW32726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029626625" evidence="2">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="46"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="310" mass="32455" checksum="FAE55A91C41D72C2" modified="2021-04-07" version="1">MNRRTLLGGLFAAVTVPALASCSSGITSLDGEGSGGGGGGSSEGGVTIGTANFTENQVLGYLYAAALEAAGVTTKVRPNLGTREILIPALKGGDIDLLPEYQGALLHYLDAKAEATEEGTMQNALAIALPPGLQILPYGEAENADAFAVTKETAEKYGLKSLADLAKHNGKLIIGAAPEVKKRTVGSVGLKDVYGVEFKEFKSLDSSGPLVKGALKKGDVDVANLFTTDTDITAEGWVVLTDPKNLIPGQHVVPLIADRKADSTVRKALARLGSVLTTEDLTELNRLVDKDRKDPEDVAYDWAAEHGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKA9</accession>
    <name>A0A7K2ZKA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MmgE/PrpD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_26855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001252">
        <property type="protein sequence ID" value="MYW32794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="3">
        <location>
            <begin position="34"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="4">
        <location>
            <begin position="289"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="506" mass="54173" checksum="AEDE009DE4A6115C" modified="2021-04-07" version="1">MIDHHVRVHPSADRLPRQEQLAWKLAAVATGTQDASALDPQAAAMAVNRIVDNASVAVASLLRRPVAVARSQALAHRATPGAAVFGAAPGVRVSPEWAAWANGTAVRELDFHDTFLAADYSHPGDNIPPLLAVAQHTGRTGAELLRGIVAAYEIHVALVRAICLHEHRIDHVAHLSAATACGLGALLGLDTETTYQAVQQAVHTTTATRQSRKGEISSWKAFAPAFAGKAAIEAVDRAMRGEGSPSPVYEGEDGFLARMLDGPDAAYTVGLPEPGEARRAILDTYTKEHSAEYQAQAVIDLARRLRERTGPTEKIRSIVLHTSHHTHQVIGSGSGDPQKYDPAASRETLDHSVPYIFAVALEDGVWHHERSYAPERAQRPGTVELWQRISTVEDPEWTRRYHDPAPERRAFGGRAVVTLADGTVIEDELAVADAHPAGARPFDRTGYVAKFRTLAEGSVAAGDQDYFLAAAEGLAELPADGLDALFPAVDTAAVTAFDAGLPKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKU0</accession>
    <name>A0A7K2ZKU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_27760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001299">
        <property type="protein sequence ID" value="MYW32966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="316" mass="33627" checksum="0239C3E687A1E7EA" modified="2021-04-07" version="1">APGGASPTAAEADPVRGEPAPSAASPYWVDPDSDAARQVRAWDRQGREDDAKALRRIADRPVALWPAWDTPGPEIVAAAKAAAETKKSVLLVAYNIPHRDCGLYSAGGAKDADAYRSWLGEFTEAIGDAPATVILEPDALPHIADGCTPPEHHAERYQLLSEAVDTLKAKPRTKVYLDAGNPDWIKEPSKIAEPLRLAGIDRADGFSLNVSNFQSNVSVKKYGALLSDAVGGGAHYVIDTSRNGGGPLTGDRAEAWCNPPGRALGTPPTTDTRDDRLDAYLWIKRPGESDGTCRGGPEAGTWWPEYALGLAERATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLB7</accession>
    <name>A0A7K2ZLB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_28755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001345">
        <property type="protein sequence ID" value="MYW33154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="29891" checksum="22EDEAD00814CC5F" modified="2021-04-07" version="1">MSTAEPDLRAKDLHLGYDDRAVVTGLDLAVPPGRITAIVGANACGKSTLLRALARLLAPRAGAVSLDGRALHSIPTRELAQQLGILPQSPVAPEGLTVIDLVNRGRSPHQTWWRQWTKADEQAVHDALAATGTTDLADRAVDELSGGQRQRAWIAMAVAQGTPVLLLDEPTTYLDLAHQIDVLDLVVDLNRREGRTIVMVLHDLNQACRYADHVIAMKKGSIVTEGAPADVITAETVEDVFGLRCQVTTDPVSRTPLVIPVGRHHTPDPEEPRKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLC8</accession>
    <name>A0A7K2ZLC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FtsK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001334">
        <property type="protein sequence ID" value="MYW33140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="15444" checksum="2DF01F290C0CDC82" modified="2021-04-07" version="1" fragment="single">GAGRPVLVLGAGPRGALSVDLADEGPHLLIEGPAGSGRTELLRAIAASLASSARPDRLGILLVDGAGGKPEEHGSSAPGLLPCTELPHVSTHLVASDPVRMREFAQALGGELKRRAELLGPLDFAAWHARHAEAAQQEESRRVVGQRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLX0</accession>
    <name>A0A7K2ZLX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4389 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001368">
        <property type="protein sequence ID" value="MYW33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515120.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001368.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025498">
        <property type="entry name" value="DUF4389"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14333">
        <property type="entry name" value="DUF4389"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="262" mass="29542" checksum="79B87C82FA30F0FF" modified="2021-04-07" version="1">MADGRWSPGRKETDADEFRPVLDIVEPGRQRRLTVFFRLLLLIPHFIVLFFLHIAAFFTVIVGWFAALVLGRLPDPVFRFLAQFLGYDMRVSASQMLLIDRYPPFALTPPPDYPVQIDVRPTALNRLAVLFRIFLMIPAAIVQSLAVYGWWALCFVWWVITLVLGRMPRPLFEATAATLRYRMRFSAYAMMLTPAYPKGLFGDDDLAVAPEHSRSATRPLVMSSAGKWLVVLFLVLGLAGNVTTSVTTTTTSDDTTELTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM21</accession>
    <name>A0A7K2ZM21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001372">
        <property type="protein sequence ID" value="MYW33319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="140"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="27301" checksum="9063192B55EF3903" modified="2021-04-07" version="1">MTEAAARRTPGTPCWVSLIVHGLNATQDFYGALFGWEFRPGPDQLGPYVRGLLDGKEVAGIGQLPPDRHLPIAWTTYLATDDAGRTAEVIRSCGGTVAVGPLDAGEAGRLVIASDPGGAVFGAWQGSEHIGTMTAGVPGTPVWNELVTRETSMVAKFYQTVFGYETEAVVSADFDYQTLHLGGRPVAALHGVGQSLPRDRGPHWMTYFEVADVDESAARVVELGGHILQPPREGASGRLATVTDPEGAAFTIVRSSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMB7</accession>
    <name>A0A7K2ZMB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001407">
        <property type="protein sequence ID" value="MYW33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="16805" checksum="21581893FFB6CB69" modified="2021-04-07" version="1">EPVEGAAPRSVEVPSVGIDAPVVRRGLDQDGAIDPPPYDLPQTAGWYGKGTEPGAEGAALIVGHVDTETKPAVFYGLSAVQPGEKVKVTREDGSVAEFTVDDVQVVTRERFDAEKAYGPRVDGRAELRLITCGGKYDQKSRSYTANVVVSAYLTGARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZML1</accession>
    <name>A0A7K2ZML1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001427">
        <property type="protein sequence ID" value="MYW33538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="249" mass="26986" checksum="3D70D96A2C0DA888" modified="2021-04-07" version="1">MHGANTAAATGPAISLEKVRETAPGLVSLYKSAGVSLEKHGLNGRRAAVYLVLDYSGSMRDYYRDGSVQALADRVLGLSAHLDDDGRVPVVFFSTDIDGFGEAGLSGHRGIIDKIVANLGHMGRTNYHIAMDEVIDHYLDSGSTEPALVVFQTDGGPTSKLAAERYLCKAAKLPLFWQFVGFGDTRSTQFDFLRKLDELAVPAKRVVDNAGYFHAGLDPRKVPDSQLYDRLVAEFPSWLAAAEAQGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMX7</accession>
    <name>A0A7K2ZMX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="9597" checksum="2AC07C97ED1A79AF" modified="2021-04-07" version="1">AVLALSFPLHPPGKPEKSRADELLGTGVPTLVVQGGNDPFGRPEEFPPGAYELAEVPYGDHGFAVPKRSGLTEARAMEVLTGAVTGWLTSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMZ5</accession>
    <name>A0A7K2ZMZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_31665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001444">
        <property type="protein sequence ID" value="MYW33702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="223"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="418" mass="45188" checksum="A94618236BC57567" modified="2021-04-07" version="1" fragment="single">MSPFPIQELTLPVALSGSDVIGQAKTGTGKTLGFGLPLLERVTVPADVEAGRATPEQLTDAPQALVVVPTRELCQQVTNDLLTAGKVRNVRVLAIYGGRAYEPQVEALKKGVDVIVGTPGRLLDLAGQRKLDLSHIRGLVLDEADEMLDLGFLPDVERIITMLPPKRQTMLFSATMPGAVISLARRYMSQPTHINATSPDDEGTTVKNTVQHVYRAHNMDKPEMLARILQAEGRGLAMIFCRTKRTAADIAEQLEKRGFASGAVHGDLGQGAREQALRAFRNGKVDVLVCTDVAARGIDVEGVTHVVNYQSPEDEKTYLHRIGRTGRAGAKGIAITLVDWDDIPRWQLINKALDLKFPDPPETYSTSPHLFEELGIPAGTKGVLPRGERTRAGLRAEEVEDLGETGGRGRKSAAPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN48</accession>
    <name>A0A7K2ZN48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_31745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001446">
        <property type="protein sequence ID" value="MYW33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="278"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="34103" checksum="C5E6DC1EF3E5125E" modified="2021-04-07" version="1" fragment="single">MPLEVVICEPLRTPIGRFGGAFAQQTPASLAAHVIAEVVARTGIAPDRVDEVILGHAYPSSEAPAIGRVAALDAGLPSTVTGTQIDRRCGSGLQAVLDAAMQVRAGFSDVVIAGGVDVMSAAPYYTHDGRWGIKGPGLQLHDSLARGRVTAGGIHHPVPGGMIETAENLRREYGISRADQDALALRSQQRAATATAEGRYAAETVPVTVTTRKGETTVTADEHPRPDTTAEQLAALRPVMVKSDPDATVTAGNASGQNDAAAACLVTSAETAERLGLTPLVRLVSCARAGVPAATMGIAPVAATRTALDRAGLTLADLDLIELNEAFAAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN72</accession>
    <name>A0A7K2ZN72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001469">
        <property type="protein sequence ID" value="MYW33787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="31507" checksum="F1729CF0F9E1B8E0" modified="2021-04-07" version="1" fragment="single">MTTYDDRASLTDLTTTAERVRRSVEGVIEGKPEVVRLSLTVLLAEGHLLIEDVPGVGKTMLAKALARSIDCSVRRIQFTPDLLPSDITGVSIFDQQRRDFEFKPGAIFAQIVIGDEINRASPKTQSALLESMEERQVTIDGKTYELPDPFMVVATQNPVEMEGTYPLPEAQRDRFMARVSIGYPSPEAELQMLDVHGGVSPLDDLQPVAHAHDIVKLIDAVRTVHVADAVRRYAVELVGATRSHPDLRLGASPRATLHLLRAAKASAALSGRDYALPDDVQALAAPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNI4</accession>
    <name>A0A7K2ZNI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001496">
        <property type="protein sequence ID" value="MYW33915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030570852.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001496.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046306">
        <property type="entry name" value="DUF6421"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19985">
        <property type="entry name" value="DUF6421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="465" mass="52702" checksum="4A48DB534626E971" modified="2021-04-07" version="1">MTEILVHGAAEGAIATAPRVVEHPAWPALRDAVEEIRPWQSKDGSIDFEAEGAPSPATVERVVERVIGAVEELSPLLPHDAAYHRALVTDLRRWAADGFRVPDFLDALLAFQPARNRVDGLQHLVVFPMYTQNGNPDRNFEAVVLKMVWPEWLADLEATRYDNPLFCGITFEDFTAGYDTNSAVLFPETIAVREAPERFSWGGIFCDREAARFRRVTEASVELLGLELPEDIREMIGDQTRCEQAFVLWDMVHDRTHSHGDLPFDPFMIKQRQPFWMYGLEELRCDLTAFKEAVKLEAEGNTHGRDVQYAVLFDRMFRFPVTGDRVRNYDGLGGQLLFAYLHKHDVVRWTDNTLKIDWERAPQVTNQLCAEIEKLYRDGIDRPKLVHWFAAYDLVSEYLAPHPGSTWAKGPDALDLTQPPRKLVDDVLPDEFPLSMFYEALAKKLKHVIASAKGITAASAEQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNK5</accession>
    <name>A0A7K2ZNK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">GT040_32915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="WWKE01001501">
        <property type="protein sequence ID" value="MYW33943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="26537" checksum="D004427B85EAAF98" modified="2021-04-07" version="1">MVHIKTDTSIEAMRESGRVVARILARAQEVAAIGVTPRELDEAAREVLREAGASSPFLNYKPHFAPTPFPAVICVSVNDAVVHGIPSAEPLRDGDLVSVDAGALLGGWAGDAAVSFTVGEARPADTELIDAATTALEAGIAAAVVGNRIGDIAHAIGTVCRKAGYGILDGYGGHGIGRSMHEDPSVPNEGRPGRGMPLRHGMVLAIEPMLLAGGLDEFRHDPDGWTLRTTDGSRAAHAEHTVAITKDGPRVLTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNT5</accession>
    <name>A0A7K2ZNT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_33210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001515">
        <property type="protein sequence ID" value="MYW34002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="326" mass="34335" checksum="763E7E9F14DBDD3C" modified="2021-04-07" version="1">MVLGARKQGATISEETRRKVLDAVRALGYVPDPAASRLAAARNNLLGVFSFTSTFPTDVQHSYYPFLVGVEQEAAARGYDLVLFTGSSTGGAGAAGPNALARVRLADGCLFLGRHAPAEELRRLVADGFPVVHLGRRDELEGLAWVGADYISASQEVVARLAALGHQRIVLVREDDEAPASTDREHGFLKGLEEAGLPGGPAAVFRSADPERELTAERLRGWLDEGVTAFVAEETDTGDAWRALHGAAHFVGIDCPRDASLALLGSPPPDLAEEPAPTGFDIPRTQLGAAAVRMLAALVSGEEATEPLVACTFRPGSTAGPAPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNW9</accession>
    <name>A0A7K2ZNW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001539">
        <property type="protein sequence ID" value="MYW34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="372" mass="42907" checksum="ECB01584882DAC8B" modified="2021-04-07" version="1">MTAIDPTAHLTAEQIEELGRELDAIRDEVIADRGEKDAAYIRKVISVQRKLELVSRGVLLFSIFPPAWVLGTAGLSVAKIMDNMEIGHNVLHGQWDWMRDPKIHSTTWEWDHVSPSDQWKHSHNELHHTYTNVIGKDNDLGYGIMRVDEDQRWHPFHLGQPLWNFLNACFFEYGIAAYDLELGKNLHKRRRKNPEFRARAKAVGRKIRKQVLKDYVIHPLLSGPSFLTTLAATFTANLVRNLWTHSVIMCGHFPEGVQVFERRSIRGETRGQWYLRQMMGSANISGSKAMHFMTGNLSHQIEHHLFPDLPSNRYAEVAVKVRALFEKYELEYVTGPLPKQVFSAWHKVFRLSLPNRKPRAGTPDHERELVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNY6</accession>
    <name>A0A7K2ZNY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TOMM leader peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001513">
        <property type="protein sequence ID" value="MYW33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="544" mass="56477" checksum="2356EFA1BBD5282C" modified="2021-04-07" version="1" fragment="single">SAPAPAPAAPAGNGTGAFDALAGTRPRIRRDVLFTETPGGVLFHNADGGFHLTGRTAYRFASLVVPHLTGHHRLDELCAGFGPAQRAMAAELVKTLYARGFARDIPATDPDTTGDDGLSPEIAERFAAQIAYVDHYTDDAPARFARYRTTRVAVLGDDETARWCVLSLLRNGCARIGTTAAHTTAHSTAHAAAHTTADTFPHDDIAAEADGAGAEIGTVGAGTDAGWADLDGYDVVVVTGSGAGPRTHRLLAAGVPEGVTLIPAWLFGRRLIVGPLSTAASTGCWSCALLRLGGNVDAGAAEALWSEAAGAVPASGDALSGPVAAMVGNLIGYEIFRLTTGALPAETDGQVLVQDLESLDVMAEPVQPHPRCARCAALDAREPAPALPDSLALPVTPTVETARDAEALVEELNRVSTALVRPYTGIFRRYDDEELTQTPLKLSRVEVALGGGVRRRIAAFDVHHLAGARLRALYAAAEAYVEHVVPLTGAVQDDPVRALHPAALTTGGGTGAGPTAWVTAASLITKEPVRVPAAALRPFGPHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNZ8</accession>
    <name>A0A7K2ZNZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_33680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="134"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="249"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="404" mass="44718" checksum="F6CE37C6C6AEFCF5" modified="2021-04-07" version="1">MDFAFDARTEELRSRLLTFMDDYVYPAEKTDHEQRALLASPWDTPAVVGELKAEARRQGLWNLFLPDAEYGAGLTNLQYAPLAEITGRSPHLAPTALNCAAPDTGNMEVLFQFATDEQKKQWLEPLLAGEIRSAFAMTEPDVASSDATNIETRIVRDGDSYVINGRKWYISGAMNPDCAVFIVMGKTDPDGDDLRRQQSMILVPRDTPGLEVRRAMQVYGYEDHSHGGHAEVVFHDVRVPAANLIGEEGGGFAIAQARLGPGRIHHCMRLIGMAERAIELMCRRAVERTAFGKPLAQQGVVQNWIADARVTVEQLRLLVLKTAWLMDTVGNKGAHTEIQAIKIATPRAVVDILDSAVQLHGAGGVSQDFPLAELWASARTLRLADGPDEVHQRSLARREIKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP33</accession>
    <name>A0A7K2ZP33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001545">
        <property type="protein sequence ID" value="MYW34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="158" mass="17286" checksum="1066DC2913C686B0" modified="2021-04-07" version="1">MDMKTAAERSDAILDAVLGEIQPELRWAHGPTTVGSCDVSRRRVVMTDISAARRGNLLGVVDRFWRKSGYRMTAVNNDAEFPAVYARTPDGFGVRLRIGGKGQAFFQVDTPCVRESAVADPTAKATAPLYEGEFIPRPNIHSDFWSAETPEVGVTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP92</accession>
    <name>A0A7K2ZP92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA carboxylase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001553">
        <property type="protein sequence ID" value="MYW34176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="275"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="532" mass="56821" checksum="DD274B53BCE4169B" modified="2021-04-07" version="1">MTVLPTGLDTNSPEYAANRATLLAKLTELEAEHAKALAGGGQKYVTRHRKRGKLPARERIELLVDPDTPFLELSPLAAWGSDYAVGASLITGIGVVEGVECLITANDPTVRGGASNPWTLKKALRANEIAFANRLPCISLVESGGADLPSQKEIFIPGGALFRDITRLSAAGIPTVAVVFGNSTAGGAYVPGMSDHAVMIRERSKVFLGGPPLVKMATGEESDDESLGGAEMHARTSGLADHFAVDEQDAIRQARRIVARFNWRKAHADPGPAEPPKYDEDELLGIVPGDLKVPFDPREVIARLVDGSDFDAFKPLYGTSLVTGWARLHGYPVGILANAQGVLFSEESQKAAQFIQLANQRDIPLLFLHNTTGYMVGKEYEQGGIIKHGAMMINAVANSRVPHLSVLMGASYGAGHYGMCGRAYDPRFLFAWPSSKSAVMGPQQLAGVLSIVARASAAAKGMPYDDEADAGLRAMVEQQIEAESLPMFLSGRLYDDGVIDPRDTRTVLGMCLSAIHTAPVEGARGGFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPA7</accession>
    <name>A0A7K2ZPA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgB</name>
        <name evidence="12" type="ORF">GT040_33815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01001546">
        <property type="protein sequence ID" value="MYW34118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="232"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW34118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="710" mass="79635" checksum="1C5C83EAB1FD20E6" modified="2021-04-07" version="1">MAGDHHDPHSVLGARSIPGGVLVRALRPFARSVTVLADDVQAELHDDGDGFFSGVLPVKEVPAYRLRVAYDDNTIEVDDPYRFWPALGDLDLHLIAEGRHEELWRALGSEPMEHQGVAGTRFTVWAPNARGVRVTGDFTYWDGTALPMRSLGSTGVWELFVPGIGEGALYKYDICRPDGSHTVRADPMARRTEVPPATASIVTASHHEWRDADWMAHRGDRPAHEAPFSVYEVHLASWRPGLTYRQLAEQLPSYVKDLGFTHVELMPVSEHPFGGSWGYQVTGFYAPTSRMGTPDDFRYLVDALHRAGIGVIMDWVPAHFPRDDWALAEFDGRPLYEHADPQRAAHPDWGTLEFDYGRTEVRNFLVANATYWCEEFHIDGLRVDAVASMLYLDYSREDGQWSPNDQGGRENWDAVAFLQDMNATVYRRNQGVVTIAEESTAWDGVTRSTDSGGLGFGLKWNMGWMHDSLQYVSKEPIHRKYHHNEMTFSMVYAYSENYVLPISHDEVVHGKQALVAKMPGDWWQQRANHRAYLGFMWAHPGKQLLFMGQEFAQGAEWSEGHGPDWWLLDPTYEASGDHRGVRNLVGDLNAVYGAVPALWQRDTAPEGFSWVDGGAAEDNVFAFLRYDADGSPLLAVSHFAPVVRHDYRLGVPETGTEGWVEVLNTDADRYGGSDVRNEEPLKAETVPAHGRPASISLTLPPLATVWFRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPC7</accession>
    <name>A0A7K2ZPC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001572">
        <property type="protein sequence ID" value="MYW34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="17738" checksum="8AC20801AC62D25A" modified="2021-04-07" version="1">GARVQGAAQIVAVDPVASRREAALRFGATEAVAPDGLADAQQRITGGEGFDYVFEVVGKSATARTAYEHTRRGGTLCVVGAGAMDDHFQVNMFELFFDEKRILPSMYGGGDVLRSYERAIALWRAGRIDLESMITHRVRLEEVNDALDQMRTGESLRTCIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPJ7</accession>
    <name>A0A7K2ZPJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_34730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001589">
        <property type="protein sequence ID" value="MYW34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="4">
        <location>
            <begin position="16"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="278" mass="29042" checksum="5330E469304551DA" modified="2021-04-07" version="1">MPEGPPPPLGRPPLTWLYVPGDRQQVVAKALGCGADVVIVDLEDAVAPDRKEYARAATAELLADPVTAAPDAVPVHVRVHGEDDIRALMGLPGLSGLRLPKITHAVSVHHVAAVAPGVPLYPLLESALGIEHAYSIASADPAVRGIALGEADLRADLGVREDSGLDWSRSRLVVAARAAALPPPAQSVFPDVRDLDGLWASCVRGRGLGLLGRAAIHPRQLEVIERAFRPTDREIEAAEEIIAASAVEAGALALPDGRFVDAAVVASARRTLAIAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPS2</accession>
    <name>A0A7K2ZPS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">GT040_34935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001595">
        <property type="protein sequence ID" value="MYW34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13281" checksum="497D697FB5E55225" modified="2021-04-07" version="1">ERLRTIAAAGTPRVLALSPAGTDQAHVARPKMWPELRVLTELGVHLVEPAPGPGANWSTLDRADTFALRPDVILTDIRAHAAPLDELRGDGYGAAPVVPWNPEPLYGPRDHARFLGLVADALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPU2</accession>
    <name>A0A7K2ZPU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_35225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001607">
        <property type="protein sequence ID" value="MYW34391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="44" mass="4748" checksum="8E6821A52CB0B79F" modified="2021-04-07" version="1">ATAAQLDALGRGAGDHLAEARVHGQRPLERGRFGMCGRLDVYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ15</accession>
    <name>A0A7K2ZQ15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF541 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_35495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001623">
        <property type="protein sequence ID" value="MYW34440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="23885" checksum="8BB5E087E3E88484" modified="2021-04-07" version="1">VTVRGEAHLEVDPELAHIAITLTARGTDRRTTLDDLTHRNTTTLDLIKSYGDTIEKLETGTLTINPELTRHGRAERIRAYHGHIQLTATLNDFTTLGELITRLADHELTRIDGPWWSLRPTSPHHATARRQAVRETLQRAREYAEALDTRLGALLELNDTGTHHSPLGRAAFAESMPYAAAAGGAEASDAAPINLEPVRQTIDAQVEASFTLIPPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQY7</accession>
    <name>A0A7K2ZQY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001685">
        <property type="protein sequence ID" value="MYW34762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="404" mass="44373" checksum="D1526D1609C331B7" modified="2021-04-07" version="1">MQVIQSTKLANVCYEIRGPVLEEAMRLEAAGQRILKLNTGNPAAFGFECPPEILEDILRNLAGAHGYGDAKGLLPARRAVVQHYQTKGIPDLDVEDIYLGNGVSELIQMSMQALLDDGDEVLVPAPDYPLWTASVSLAGGTAVHYRCDEQADWMPDLADIERKITDRTKALVIINPNNPTGAVYDDEMLRGLTEIARRHNLIVCSDEIYDRILYDGATHTPTAALAPDLMVLTFNGLSKNYRVAGFRSGWLAVCGPKAHATSYIEGLTILANMRLCANMPSQHAVATALGGRQSIEDLVLPGGRILEQRDVAYDLLTSIPGVTCVKPKGALYLFPRLDPKVYKIKDDRQMVLDLLRAEKIMVVQGTGFNWPEPDHFRIVTLPATEELTDAMTRIGSFLDGYGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRX3</accession>
    <name>A0A7K2ZRX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001774">
        <property type="protein sequence ID" value="MYW35106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="SSF48056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="2">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="33295" checksum="340C24CDFEB75C64" modified="2021-04-07" version="1">MYTRKNQRDLTRTEKRRLVDAILKIKKSGRYDDFVVMHREYYVMDTENRPRPAHMTSSFFPWHRRYLLEFERALQAVDPGVSVPYWDWTKDRSTTSSLWAEDFLGGNGRAGDRRVTTGPFAYATGNWSVGRGVTDQNWLTRNFGRPGNNPVSLPTADDVARALKDPVYDTEPWNSISTEGFRNRIEGWGIHRVRDVGNHNRVHQWVGGPMAGAASPEDPVFWLHHSFIDLLWDRWRKAHPKAAYLPGRKPASPGRDRAYVFGLDDPMPPWDVTPRKLLDHSKIYRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS89</accession>
    <name>A0A7K2ZS89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001781">
        <property type="protein sequence ID" value="MYW35158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26260" checksum="60AA13C94F43501B" modified="2021-04-07" version="1">MGTYVLVHGAMHGGWCWRSVRDLLSRAGHRVFTPSLTGQGEHAHLLGPDVGVATHVQDVAGLLHYEDLSEVHLVLHSYAGVLAGPVAERAVGRLASVTFLGAFLVRPGECLLDVEPPETAQRYRALAAEKGDGRYLPADASFLAQWGITEEELAAWVAPRLTAFPLRCQTDAVDFDPAPLAALPTSYVRHTRPPLPSLERSEDRARAHGWDVHSLPTGHDMMLEAPGATTDLLTRITGREES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSA9</accession>
    <name>A0A7K2ZSA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_39675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001806">
        <property type="protein sequence ID" value="MYW35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="10465" checksum="78911B2446E15D97" modified="2021-04-07" version="1">MTVQDQTLARDLQSVAGLTELITVLYQEALGNEGLDEHADFFESGGDSLTAFQITGRIQEAVDTEIAIALVFTYPTPAELAEVVAEELADLPAGATHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSL1</accession>
    <name>A0A7K2ZSL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001835">
        <property type="protein sequence ID" value="MYW35333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26685" checksum="9AA8008A1AC96733" modified="2021-04-07" version="1">MGHGWEGVVLKLFRGRDFTFTVTGAEQVTDRFRRVHVTDGGLLAATGGAHPTMWVRLWFEKDGKPHQRAYTLVDPDSEAGTFSLEFALHEGPACDWAKETKPGDTIDATLQGTGFTLPDPAPKRLFVIGDPAALPAINSLLDAIPQTPATIWFESSDEDDRKLPFRLDEAHHTLHHVERREGGAHLVAEVKAALPGLLGDDHADAYVWVACDTSTTRTLAAYLRKELGLPKDRVNALGYWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZST2</accession>
    <name>A0A7K2ZST2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_40535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001843">
        <property type="protein sequence ID" value="MYW35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="421" mass="41807" checksum="FD20E0A9B8E0A88B" modified="2021-04-07" version="1">MKDLPVMDAPTRRWRAALFLFMFAAGVSLASWVARTPAVRDALDASTGAMGLVLFGLSVGSMGGVLVSGGLVRKYGGRPVIAVGAGLFVAGLLVIAGGTALEVSGGVFAGLALFGAGMGLAEVAFNIEGAAVERTAGRPVLPVLHGCFSLGTVFGALLGMGLTAVAFPVGWHLTGIAVAAAVAGLWTVRAIPSGTGREETEAGDDGERPGGLRAQLAVWSDRRLVLIGLIVLAMAFAEGSANDWLPLLMVDGHGTSATAGSLTFMLFAVAMTTGRFAGGPLLVRFGPAAVVRASAVVATVGVALVIFSSSALLAGAAVVLWGLGASLGFPVAISAAGEGEKEAAARVGAVATAGYVAFLVGPPALGFLADHVGLRLAMIVVLVLLAVAALVAGALRPAGAVRRTDAAGSSAEASSAQSDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSX9</accession>
    <name>A0A7K2ZSX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001846">
        <property type="protein sequence ID" value="MYW35408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16379" checksum="1DA72532E42DD98F" modified="2021-04-07" version="1">MTRTLSWKLVIDSADPHAQAGFWAEALGYLIEDNSALVEQLLAAGAIPGPITTQAHGRAAWRDLAAARHPDDPYDETSGTGLGRRLLFQRVPEPKTVKNRLHIDVHTAPGERDAQAERLVALGARILRAVDEPGGSWLVLADPEGNEFCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z616</accession>
    <name>A0A7K2Z616_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000013">
        <property type="protein sequence ID" value="MYW27784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="11803" checksum="07B3E08BC1508534" modified="2021-04-07" version="1">MSTSISDPVVERFVAAVNAGDEAAFTAVLTEDATMSDDGSERDLAAWTEKEIFSPKANGRMDVVQTSDDGRTLVVDYTNDTWGTMRTRWSFTVTGDRISRFETGQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6B8</accession>
    <name>A0A7K2Z6B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Resuscitation-promoting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000036">
        <property type="protein sequence ID" value="MYW27862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="48" mass="5059" checksum="3D9B675525EC28CA" modified="2021-04-07" version="1" fragment="single">MNGVNTSQNRRLDAFHEQLTVADRAWTAGPAAHAPTVVDVPLAAPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6F7</accession>
    <name>A0A7K2Z6F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000057">
        <property type="protein sequence ID" value="MYW27924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029754565" evidence="2">
        <location>
            <begin position="30"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="18584" checksum="FA4C9F744E499979" modified="2021-04-07" version="1">MMRRQMKLAAVLVVVVLALTGFSTSTSGGKSGKSRSGSSSGGGCSSSKKSNNGYRDTDYDDDYDDSSSSGSSGSYSTPTPTASDEALDVRVIRCAAPRKGKRKAVTSSLLEVRSNYPGTQAYEIDVRFVDARGRTVDTAEATTILDVGEEDTLTVRMDSPGQVSKVKRCEVTAKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6J0</accession>
    <name>A0A7K2Z6J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase /reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000059">
        <property type="protein sequence ID" value="MYW27948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029581673" evidence="1">
        <location>
            <begin position="34"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="22595" checksum="9B7A671CFDA1EF1D" modified="2021-04-07" version="1">MSRTRTRTAALFTVPLVVAGVLATTTAATPAGATTPRPGPSLTCQGQGVDAKALVRARAETVIDASSATVWKLQTDVERWPDWQAHVTGVDRLDHGRFRPGSAFRWTTPIPPNPATPATSLDITSTVGQLKPNSCIRWTGPAVGEGLHIDGVHVWSFTKVRGGVLVRTEETHTGEQVDANVPYATEILQQGLDAWLADLKTAAEARSCPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6P4</accession>
    <name>A0A7K2Z6P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000070">
        <property type="protein sequence ID" value="MYW28017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16093" checksum="2B93A1D363C23536" modified="2021-04-07" version="1">MSADSRRGTNLGPTDSGSTDTTAADPQSSRWYDAEAGPVVRPYAMTRGRTSSASRHRLDLIALVVPEPAAEDPGRDQTLAPEHVTIVELCSDAPQSIAELAAELDLPVGVVRVLVGDLVEDELVHVTRPVPPAELPDVNILREVINGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6V3</accession>
    <name>A0A7K2Z6V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000092">
        <property type="protein sequence ID" value="MYW28076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="11749" checksum="ED6334EF0980DB59" modified="2021-04-07" version="1" fragment="single">LLAGGAAIGSYALLVPLVLLQAVTAAGWFRLNGMWPARQGIALAFLGGLVADAALLAAGREHGPTALLGTLGVWVLLAVVLQLRSPATGEERMYGLMATVVSAALAVLAAGHLAAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z724</accession>
    <name>A0A7K2Z724_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000105">
        <property type="protein sequence ID" value="MYW28149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
        <property type="entry name" value="PTHR40053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="34065" checksum="55528DDA9276A2C4" modified="2021-04-07" version="1">MVFKKLLGALGVGGPSVDTVLQPDPALPGGPLSGEVRLRGGGTDVTVEQISLLLVARVEVEGHGEEHDSTVVLERFTVGGGFRLAQEAEHTVPFTVTLPWETPVTQLHGQPLGPVLGIRTELEVAGARDKGDLDALAVGPLPAQEAILEAFGQLGYGFKSADLELGHIRGTGQRLPCYQEIEIVPPVGQAHAVNEIEVTFLAAPDSLEVVIEADKRAGLFSGGQDTVHRFTTSHHAVPQADRNAEVDAWLQQVIGAHASHAAPYPYAQGGGHHDDHHHRSGPGTGAVVAGVAAGAAVGVVGGMVAAEVIDEIGDAFEGEDEGEGGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7A6</accession>
    <name>A0A7K2Z7A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_02625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000112">
        <property type="protein sequence ID" value="MYW28193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511982.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000112.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22346" checksum="B3B098054020E7A6" modified="2021-04-07" version="1">MESSGTTRRQATRQRLYEAAVTLIAEQGFSATTVDEIAERAGVAKGTVYYNFKSKTELFEELLRHGVGLLTASLRAAAEESEERGGTRVEALDAMIRAGLAFIDRYPAFTQLYVAELWRTNRAWQSTLLVVRQEAVAVVEDVLREAVRSGELSEEIDIPLTAAALVGMVLVAALDWQAFQPERSIDEVHSALSLLLHGRVSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7E3</accession>
    <name>A0A7K2Z7E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_03045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000143">
        <property type="protein sequence ID" value="MYW28276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="97"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="335" mass="35806" checksum="C06379A629C0B4CC" modified="2021-04-07" version="1">MSITATDVAVLDGAPAPEAPTRRARLRFLRGGKTRTGLLMLAFFVLLAVIGPWIAPYDPDAMSDQLLQPPSGAHWFGTTHTGQDVLSQILVGTRGVLIVGFVAAVIATVLSVLIGVTAGFIGGAVDEILSALANIFLVLPGLPLIIIVASFVPDTGDLLIAFAIALTSWAWGSRILRAQTLSLRRRDYVEAARATGESTWRIILFEIMPNLTAVIASGFVGTVIFAVLTEITLAFIGVADISHWNWGTVLFWAQSNQALAQGAWWWFVPAGLCIALLGTALALINFGIDEFVNPRLRTATGSSRKVKMRVGFTPVARKPLGGARPEPSTSKEPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7H3</accession>
    <name>A0A7K2Z7H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan DD-metalloendopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_03240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="947"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="4">
        <location>
            <begin position="1431"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="1568"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1746" mass="184112" checksum="9D5926F86FED93A2" modified="2021-04-07" version="1">MPDLDIVGGAAVDVVPVIPQFHTKLKALVLPIADKVGEEAGRKMGEAISKNIVISIPSAINQGGKAGVRAAGKQGDDAGGAFARSIRRKLQAAFKAMPKLDVKLGDTGVDAELARIRAKLEQLSNKRIGIDVSAEAAQAEVARLEEQLRRLGAAHPNVAVRADTATARAALAEIRSEISALTRRPGVIELEVDGALGAKMRAAIAQAQASLPEINVSADTSPARAEIQSLRERLATLADARIGIDIDAGEALAQISAVQERLLVLSLTTADVDVRVDAGAAAAELAALQAMADDTKTFRIDAVANTSGALMAMVMLTAQAAALVAIPIGPVLTAGLGAVLSMSTAAAVGVGAVGLAAIPAIKGVAEALKAKTAAEKEAAQATDDSAKKSVQAAQRALQMAGAQASLASAHRNAARSIAQANRGVEEAEKAVADAVQRAADQRKASADAIKRAQDGLSDSHRRLRGAQEGLTDAHRGLRDAQESLTDANRNARQAQEDLSRARVDAAQKLRDLNDELTNGALDQREATLRVQQATEDLNKTKADAAVGKATQLDLDQAQLAYDRAVARAKQQKQDYAELQKSADAQKKAGVEGSQAVKDASDRLADAQRTVVDRTEAIADAQRTIVDSTEAIADAQKGVRDAAVAVADAQSKAARDQVDAAEAIVEAQQGVSDAITTAADAQVSAAESIASAERGVESARLSGIDTTTEAITKSDEYREALAKLTPEGRDLFDALAGPDGLIGAFKDWSRELSPDVLPLFTTGVVSLKDSLPGLTPLVEGAASGIETLMDKASAQMKTPFWESFKADLAENVEPAVVGFGVAFGNVIVGIVGIIDAFLPKMDGIAAHSDRITERFAKWGTSLKGSPEFEKFLQYVKDTSPGLAEFIGEVLSTIVDLSKALAPLTQLLFETITPLLDAVQWLATNVPELIVTLWLLYAVQKAITVGMAAFAAAMMLYQSVMIIATIATSGWAVALNATGIVPIIRAIVLVVGLLVAAVIYAYKNWDWFRITVDTVAGAIKTAAVWIWEEGLKPAFSGIWTAMKAVGEAAVWLWENALSPTFDFLYEAGQLLATALIVTFLLPAKLAAEALGAVGKWLWEKALGPAFQSIADDATWLWEEVLSPVFGWIGEKAVWLYEKAVSPAFKWISDKFDDAGDDATWLWEKVIRPVFNWIGDKAEWLYEKGLKPAFDDIMEAVGEVADSFEDAKKFIGDAWEAIGGIARKPVKFIIDKVYNEGLVPLWGRVASITGADPLKPFKGFHTGGIMDGYSPGRDDRVIAVGGGEAIMRPEWTRAVGADTINSWNAAARSGGVGGVQRAISNGMPAFKDGGIVGWFKDKAGDVSDFLSGAADFVNPSKLFDKAKGYLSSKMEPILENRWSREVAKLPLKMLSGLKDTALGVLGFGGGGSGPWAKPVNAGYGTPFGKPGLMWSSGRHTGLDFPAAIGTAVKAVADGKVAMAKSGGPYGNHIMLNHGGGLTSLYAHLNSILTSVGDNVKRGQKIGTVGSTGNSSGPHLHLEARVNGKAVDPMTYLSGGGGAGGKGVQRWRPVVKAALAATGNPASYADLTLRRMQQESGGDPGVVNTWDSNAARGTPSVGLMQVIKPTFEAFAGMMRTQGPFKYGVSVDPMANIFSSMRYAKSTYGSLPRAYNRPGGYAKGGYPQVGEMAWVGEQGPELLEFLTPTRVYSNSDSTALARATQSIPAQSTTAPTIQADVRVYVGDREITDIVRVEVDARQNETAAALEIGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7L7</accession>
    <name>A0A7K2Z7L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14611" checksum="AD46EC1BA2818582" modified="2021-04-07" version="1">MIVPDGEIRGPELPEGVLGIDSKTGEPHEWHPMTVAWWQTWRESPQASTFTATDWSFLLDTALMHHNFWAKAQWTLGAEVRLRAAKFGATPEDRARLKLKVDDPTSAPQRPAQAPAGNVSDINSRRARLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7T8</accession>
    <name>A0A7K2Z7T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000149">
        <property type="protein sequence ID" value="MYW28373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="188" mass="20175" checksum="A7262EE26420D964" modified="2021-04-07" version="1">MTTTDPAPSEPRPEPRVPPPPRWAVRAARVAAWSTVPSGVWRIALVLGVPVGVMEREEFLAGFPDHSPLIALAYVLLIGAVAEAASYLTLGLVRPWGEVVPRWVPLAGGRPVDSRLAVLAASLGALTVTVLWWVLFFGGLLTAPSPDPGVPAGEALFVAAYSPLLLWGPLLAAVTWSYHRRHRARTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7U4</accession>
    <name>A0A7K2Z7U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trimeric intracellular cation channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_03765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000157">
        <property type="protein sequence ID" value="MYW28411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23228" checksum="61515D8824BDDC5C" modified="2021-04-07" version="1">MLTELFTPSVQHALDLVGIFVFAISGALLAVRKNFDVFGIAVLAEVTALGGGLFRDVMIGAIPPAAFTDLGYFTTPLFAAVLVFFLHPHVERIQVGVNVFDAAGLGLFCVTGTVKAYEYGLGLTASAALGLATAVGGGVLRDVLANEVPSLLRWDRDLYAVPAIVGATMVVLCIRFDTLNALTSGTAVIAAFTLRLLALRFHWRAPRAYNRSSARAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7V6</accession>
    <name>A0A7K2Z7V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000153">
        <property type="protein sequence ID" value="MYW28393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="22883" checksum="483864FC64422E0F" modified="2021-04-07" version="1">MAAVRLDGRIERGNQTRQLILGRAVQIASVEGLEGLSLGRLAAELKLSKSGVFALFGSKEELQLATVRAAVAVYVDHVLRPARSVPPGIGRVWRMCEAWIAYSRERVFRGGCFFYAATAEFDARGGKVHDALAAAQTGWVTFVEETIEEARAAGELAGDTDVRQLAFEVIAFLELANAESVLQNNSLGYGKAARAILGRLRAAATEGARLPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7W9</accession>
    <name>A0A7K2Z7W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000164">
        <property type="protein sequence ID" value="MYW28436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="12191" checksum="D30166EC6297C2F7" modified="2021-04-07" version="1">MSREGAARCGPELVSPEGIEAQTCVMTGGGETWARAYHRNTSGRELRAVLTLMGPGGRTVELHCVLAADDEPGSCETPRGVSAGGPGTYAAVAEYAGAGPVEEAPLLLRAGSHRAPGASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8A6</accession>
    <name>A0A7K2Z8A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_04500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000200">
        <property type="protein sequence ID" value="MYW28548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="40"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="360"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="607" mass="65444" checksum="8AB4176981865BE2" modified="2021-04-07" version="1">MKPDALTWTPPPDARAASGRPPGEVRRILRLFHPYRGRLAVVGLLVGASSLVSVASPFLLREILDTAIPQGRTGLLTLLALGMILTAVMNSVFGVLQTLISTTVGQRVMHDLRTAVYTQLQRMPLAFFTRTRTGEVQSRIANDIGGMQATVTSTATSLVSNLTAVIATVVAMLALDWRLTVVSLLLLPVFVAISRRVGRERKKITTQRQKQMAAMAATVTESLSVSGILLGRTMGRSDSLTQGFTEESERLVDLEVRSSMAGRWRMSIIGIVMAAMPAVIYWVAGLTIQPGGTAVSIGTLVAFVTLQQGLFRPAVSLLSTGVQMQTSLALFQRIFEYLDLTVDITEPEKPVRLEKIRGEIAFENVDFSYDADGAPTLSAIDVTVPAGTSLAVVGSTGSGKSTLSYLVPRLYDVTGGRVTLDGTDVRDLDFDTLARAVGVVSQETYLFHASVADNLRFAKPEATDEEIETAARAAQIHDHIASLPDGYDTLVGERGYRFSGGEKQRLAIARTILRDPPVLILDEATSALDTRTEHAVQEAIDALSAGRTTVTIAHRLSTVRDADQIVVLDGGRIAERGTHEELLDRDGRYAALIRRDSHPAPAPVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8C7</accession>
    <name>A0A7K2Z8C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000212">
        <property type="protein sequence ID" value="MYW28610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="560" mass="60022" checksum="9B279A3D12C7AB1E" modified="2021-04-07" version="1" fragment="single">MIFILTGEKLMDADEDLAFESRGPYSRLGRKVKQLSALIDKSVHDIGESMPDDLAESYRKAMGTLIDDGGKNYLKDFAGQLDKIAEGRRKTSMDIMESKWQVIAEIIRLLIEIAIYLAMSFFTGGASASQIMLAKMRSRFFILTTLSHLLQRLHLTPSLTEAFAEAFTTFAVRLAMMNFAPDGRRPDSIDWSDIGKAAAFGAAAGFFTSIFENVARNIVRSFDGKFLKNGPDLDFKNPNWRDTPNIDIKGNGPTPNPKPGPEVDLPKDRPGPELNPPGNGPGPSPNPVPVTFRDGPLAFRNNPELWRNSNILRFNLDRPGVLAGRYGIKGTVDFIAAGAGEVVGEILIKGAFEGDWSSSWTTFVGAGVSSRVESTLMGTALNSAAELRHVIDKMRLQQPPTVSGGASDSATRGAGNGPDRAEGPPRTDGTGGGGDAGLSSPPPVVQQTTGQGDFSGSQSPPPYVSQDPPPYFSADPPPYTPGPLPVTAAENALWQQVHQGPAEVREQALRELAALRGTQTPGPAEIGVRDGVHERLSQLPEIRVVPTGNTPAGQVDTDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8K8</accession>
    <name>A0A7K2Z8K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000226">
        <property type="protein sequence ID" value="MYW28658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="11"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="186" mass="20345" checksum="40C91694A55FBB13" modified="2021-04-07" version="1" fragment="single">MMTGSTGTPQRQGTFFISYSPADEAWASWIAWTLEEAGFRTVIQAWDFVAGSNFIDYMDRGVSESVAVIAVLSRNYQGSRYGRMEWQAALRSEPDQPDRRLLTVRVDEAPVEGLLATITYVDLVGVPDARTARGLLLTRVEQALDGHARPVDSPSYPGGGQTLSPAVPAQSWRQPLTGGAERGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8V0</accession>
    <name>A0A7K2Z8V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="6983" checksum="C281D049F232A630" modified="2021-04-07" version="1">MTRKTSGGDGSALEWFKSSYSSNDGPACVEIAAASSTVHVRDSKDLAGPQLGFAPAAWADFVPYASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9E8</accession>
    <name>A0A7K2Z9E8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acpS</name>
        <name evidence="10" type="ORF">GT040_06685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01000302">
        <property type="protein sequence ID" value="MYW28967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="14188" checksum="AFCCA0566F5D3D2C" modified="2021-04-07" version="1">MSQPLIGVDLVPLARVGELLDPGAGPVLGRFLSAGELAASRTPDGEPDRAGIAGRLAAKEAVFKLLGAVGRPVPWQGIEVLRGPGGRPGVRLSGAAAELAQHAGLGPIDVSISHDGGFAIAVAAATTSRTSPLDHLIPLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9K8</accession>
    <name>A0A7K2Z9K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase subunit DhaK</fullName>
            <ecNumber evidence="2">2.7.1.121</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaK</name>
        <name evidence="2" type="ORF">GT040_07060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.121" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000316">
        <property type="protein sequence ID" value="MYW29040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012736">
        <property type="entry name" value="DhaK_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02363">
        <property type="entry name" value="dhaK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="330" mass="34256" checksum="61A5F9D731F9FC25" modified="2021-04-07" version="1">MKMLINVPETVVADALRGMAAAHPELTVDVENRVVVRRDAPVAGKVALVSGGGSGHEPLHAGFVGPGMLSAACPGEVFTSPVPDQMVRAAAAVDSGAGVLFVVKNYTGDVLNFEMAAELAEDEGIQVTQVVVDDDVAVSDSTFTAGRRGTGATLFVEKIAGAAADEGAPLERVASVARQVNGSSRSFGVALSAVTTPAKGSPTFDLPSGELELGIGIHGEPGRERRPMMTSGEIADFAVDAVLEDLRPDGPVLALVNGMGATPLLELYGFNAEVQRVLAERGVPVARTLVGNYVTSLDMAGCSVTLCQVDEELLRLWDAPVETPALRWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9K9</accession>
    <name>A0A7K2Z9K9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="12" type="ORF">GT040_07005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="WWKE01000314">
        <property type="protein sequence ID" value="MYW29029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="11">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW29029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="21698" checksum="5A55565B40AF7ABC" modified="2021-04-07" version="1">MAATSRGTSPVPPDVRPRLTVLSGPSGVGKSTVVAHMRTVHPEVWLSVSATTRKPRPGERNGVHYFFVDDEEFDKLVANGELLEWAEFAGNRYGTPRRAVLDRLDAGEPVLLEIDLQGARLVRQSMDDARLVFLAPPSWEELVRRLTGRGTEAPDVIERRLTAAKVELAAEAEFDTTLVNTSVEDVARELLALMLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9L4</accession>
    <name>A0A7K2Z9L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000311">
        <property type="protein sequence ID" value="MYW29018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="12946" checksum="B0FC59F3F8E694D4" modified="2021-04-07" version="1">MTQSERNERQRLRPAPLLFEPSEAVADPEHFFDLESMDDPRELLARATELTQAFRAATDRSVEFQAIAAAQLADPRRFDRLTAADVAERAEWTEDYAKKMIEFGRSLLDASSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9V2</accession>
    <name>A0A7K2Z9V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000353">
        <property type="protein sequence ID" value="MYW29119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="177"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="31117" checksum="077716FB3D811B6A" modified="2021-04-07" version="1">MAGADRAKEWARHWTYAELPDLDLLRARYVRHTFPRHSHEGYVFGAVTGGVEDVGLPGGLVHAIPGTVVMINPEVPHTARPGQPEGWAYDTLYPSAQVINDIAAEVTPLRGTVGFGETRVTDPYAARLITQVHRAAEEGNALAADSLLRVLVVRLLTRHGSSLPGVTPRAGGARDAERARRALEGRMSAPPTLETLAAELGTSPFALLRAFKKEYGMPPHTWLTDARVRRARRLLDEGIAPAEAAVAVGFTDQPHLNRHFTRIVGVPPGAYQRERGVYRRGRDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9X9</accession>
    <name>A0A7K2Z9X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_07575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029807448" evidence="3">
        <location>
            <begin position="30"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="259"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="524" mass="54365" checksum="3EA848A3CB8C68F0" modified="2021-04-07" version="1">MRPSFRPTALALLISAAATGTLTLWAVTAAPDSVRTPLAWGAGAAAVLLSVCVAVTVHTLGTARTLRSLRAADSQRFTSETSRLVSASAAEAQRFTAETARIKAAASAETVRVATEARAEVERVSAEAAAERSRLSVTVDRLTARATRAETERSAAVAACANAAGRMQALATSMLADLREMEHRHTDESVLGDLLYLDHRTAQAGRLADSIAVLTGARSGRRWAKPIVMESILRGAMGRIGSYQRVRLHSTSDVAIAGHAAEGVMHALAELLDNAANFSPPTAEVHVYVEEVPAGIVITVEDSGLVMSEVQLRRAEKAVSADHQDLTNLSGTRLGLAVVGRLARKHGLTVSFRPSARGGTGALMMLPQDLISRATAPAPGPASALPAPAASAPVEPEPSHASAAGADTAGTTPTARTLTAVDSATPLTPAAGSERTDSGQPEAERPESESESTGTVPAFGESGLPKRRRGRTLAAAEARTGNATPGGADNPRARTTDPKVQAARFSTFSRAVRANSPHPEGNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA78</accession>
    <name>A0A7K2ZA78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_08105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000371">
        <property type="protein sequence ID" value="MYW29243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="246" mass="26364" checksum="EF76B5ED6F6FAA4F" modified="2021-04-07" version="1">MPVTSLGTVVAENAIRFLGHDTHEHDEPHLVYVVSGSALLTADGEEWRLGRNEALWLASRVPHALRIEPGGMALGPFLNPSDQPRCRVQPLGVVPAIVEVMTTTLGAAPTTAEQVQPFRQALGRVLSGLSRPYFPVVLPTHPAVRALAREALRAPAVTLEQLAERHRMSARQVQRVVLDETGLPFTRWRNRARMNAAVEHLRGGGELTAAARAAGYATRAGLLRALSRESGVPVSALTADAVGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAX0</accession>
    <name>A0A7K2ZAX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine/betaine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_09075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000413">
        <property type="protein sequence ID" value="MYW29425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029806861" evidence="2">
        <location>
            <begin position="22"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="46"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="322" mass="34499" checksum="396003DC182FEEB8" modified="2021-04-07" version="1">MRRRVLVAAASLVLLVGGCGLKSGSPMVDDVSPGSVGQGEPLKGATLTVTSKNFSENIILGQMTGLVFKAAGAEVLDRTNLPGSISAREAIINGDADAQWDYTGTGWITFLGHADPIADPQEQYEAVRDEDKGNGVVWLPPAPLDNTYALAISKKNNARYKLKTLSDVAALAKKDPGAVTICVENEFASRDDGLPGMEKRYGMKIPAGNIQKMDAGIIYTQVSKSDSCLLGEVFTTDGRIKAMDLDVLEDDKNFFPNYNASPVVHLATFEKYPVIAELLAPLAKKLTTEVAQTLNAKVDVDGEDPHEVAKDWLVAEGFIEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB50</accession>
    <name>A0A7K2ZB50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_09730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000451">
        <property type="protein sequence ID" value="MYW29548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="273" mass="29413" checksum="F7783F94D3305733" modified="2021-04-07" version="1">MPKEQTTKAPLPSSGVGAAAVRLADVAVRFRSKKRDVTALSDVSLDVAPGEFVAIVGPSGCGKSTLLKLVAGLLTASSGEVLLGGERVTGPRHDIGYVFQRAALLEWRSALRNILLQAEIRRMPAAQARGRADELIRMTGLTGFEDAYPHELSGGMQQRVALCRALLHEPPVLLMDEPFGALDALTREQMNTELNRIWRSTGTTVLLVTHSISEAVYLADRVVVMSPRPGTITEIIEVGLPAERDYSETLGRPEFRAAAAHIRDLLGAVSAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB87</accession>
    <name>A0A7K2ZB87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
            <ecNumber evidence="2">1.5.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ssuE</name>
        <name evidence="2" type="ORF">GT040_10155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.38" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000464">
        <property type="protein sequence ID" value="MYW29630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052873">
        <property type="term" value="F:FMN reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008752">
        <property type="term" value="F:FMN reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020048">
        <property type="entry name" value="NADPH-dep_FMN_reduc_SsuE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03567">
        <property type="entry name" value="FMN_reduc_SsuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="19118" checksum="F6B3780D3F990B2D" modified="2021-04-07" version="1">MATVLSVSGSPSATSRTARLLRHLDADLSAQGHEVIPLDVRTLPAEALLGADFAHPEIVRATELFARADGIVIGTPVYKAAYSGLLKTLLDLLPQYALTGKTVLPLATGGTTAHVLALDYALRPVLSSMGAAHIVPGWFVLDRHITAGDDGSVVLDPASAAPLDQVVAQFAAALDRTAPIPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBA2</accession>
    <name>A0A7K2ZBA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000458">
        <property type="protein sequence ID" value="MYW29592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="395" mass="43606" checksum="904EB1EC90BF4D30" modified="2021-04-07" version="1">MTIISDATAQDPTEELFSWFRTKLDTTPVYRDEEKGWQVFGYDDIARILADTTTFSSDTASAFNPPQPDLDFFDMGNLVTTDPPRHRQLRSLINSGFTPRAVAGLTPMIERITHTLLDAVDGKDRFDLIDSVAYALPITVICELLGLPMEDEPLFRVWGEALGTVDAATVPPDQLRDEVAPAVRDMNAYLMDQVGRRRKQPTDDVISKLANAEVDGKQLEDGEIVGITGLTMFAGHATTMALIANAVLLFDRHPESGAAVRADRSLLRNAAEEVLRLRPPFPRLARVVTADTEIGGHKIVAGELVTPWIGAGNRDASRFPDPDRFDIHRHTGSSLVFGQGIHFCLGAPLARLEGRIALDILMDRYADIAVDASEPVEFENPWQLITPKRLPVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBW8</accession>
    <name>A0A7K2ZBW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000513">
        <property type="protein sequence ID" value="MYW29860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="23173" checksum="53133C89674011EE" modified="2021-04-07" version="1">GAAHRGVLAVGGATAAVLACGVDIPYPRGHAELIGRVAQQGLLVAELPPGAHPTRSRFVLRNRVIAALTRGTVVVEAEYRSGSLVTARQAQRLGRFVMGVPGPATSGLSAGVHELLRGEGVLVTDAAEVAELIGEIGDLAPDRRGPVLPRDRLDPGAARVLDALPYHGPVSPRDLARGAGTSADETLARLYELHSLGFVEREGDGWRLTRPSPCGGDARRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC25</accession>
    <name>A0A7K2ZC25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000513">
        <property type="protein sequence ID" value="MYW29858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509621.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000513.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="19887" checksum="527308F1A2EB0F5E" modified="2021-04-07" version="1">MAEHRTMQRGALLDAARSLLSEGGTEALTFPALAERTGLARSSVYEYFRSRAAVVEELCAVDFPVWAAEVENAMQRAETPEAKIEAYVRRQLDLVGDRRHRAVVAISASELDAGAREKIRAAHGGLIAMIVEALGDLGHTQPRLAAMLLQGSVDAAVRRIELSVAEEPGVIADTAVAMILRGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCF5</accession>
    <name>A0A7K2ZCF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000562">
        <property type="protein sequence ID" value="MYW30036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="34"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="466" mass="50519" checksum="1CF673CA8A119E84" modified="2021-04-07" version="1">MSTVSTVNGGISFWYAQEGTPAPREPLPGDTSADVCIVGGGYTGLWTAYYLKKAVPFLNITVLEAKFCGYGASGRNGGWLYNGIAGRERYAKLHGHDAAVRLQKAMNETVGEVVRIAAEEKIEADVHRGGVLEVAHTPAQLARLKDFHSVEIAFGETDRVLRGARETAERVHITGAVGSTWTPHGARLHPAKLVKGLADTVEALGVTIHESTPVTEIKPKHAVTPYGTVRAPYILRCTEGFTAGLKGLKRTWLPMNSSMIATEPLPARVWDTIGWEGRETLGDMAHAYLYAQRTADDRIAIGGRGYPYRYGSATDNDGRTRPATIAALRDLLVRLFPTTAGVRIDHAWSGVLGVPRDWCATVTLDRSTGLGWAGGYVGSGVATANLAARTLRDLIQQDSGQAGPTDLTTLPWVNHKVRRWEPEPFRWLGVHGLYAAYRGADRRETTSPRPGTDPIAKAADRISGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDA9</accession>
    <name>A0A7K2ZDA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000655">
        <property type="protein sequence ID" value="MYW30340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7260" checksum="BC8BD4A204969BA3" modified="2021-04-07" version="1">MHATGACPSHGEKGLTAVDCSASAPQKWSFTTWPDDSVEVRSVATGACLDDSAAPGLRALPCTGRSRQQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDI4</accession>
    <name>A0A7K2ZDI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_14295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="37198" checksum="91021390FD0B1B02" modified="2021-04-07" version="1">MAKVTRDDVARLAGTSTAVVSYVINNGPRPVAPATRERVLAAIKQLGYRPDRVAQAMASRRTDLIGMIVPDARQPFFAEMAHAVEQAAAERGKMVLVGNSDYRDEREVHYLRAFLGMRVSGLILVSQGPSERAAAEIEAWDARVVLLHERPEAIDDVAVVTDDVGGAQLATRHLLEHGNAYVACLGGTEETPSVGDPVADHVEGWRRAMHESGRSTEGRLFQAPYNRYDAYQVALGLLAGPDRPPAIFCATDDQAIGVLRAARELRIDVPGELAVAGFDDVKEAGLTDPPLTTVFSDRPAMARAAVDLVLDDSLRVVGSRRERLKQFPSALVIRRSCGCGEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEC0</accession>
    <name>A0A7K2ZEC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000734">
        <property type="protein sequence ID" value="MYW30703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13624" checksum="BA24E5633606E7F6" modified="2021-04-07" version="1">MHRRVGHTERSAVGEVRRELREFLRHRSGPEQVEAAELLLSELVTNALIHTRHGAVVTATATPAALRVEVQDFESDLPAPYVPNADDGTHGRGLILVRSLADAWGVEARALGKVVWFELRGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEE6</accession>
    <name>A0A7K2ZEE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rod shape-determining protein MreC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_15975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000753">
        <property type="protein sequence ID" value="MYW30734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="105" mass="10700" checksum="01044744BD233DF5" modified="2021-04-07" version="1" fragment="single">LVLSSARAAAAYAGPRDAGPLLVVDMGAELTEVTLLVGGRIADARQAETGLSDLDPATLPATLVGTVLDMVKSMWRQDRHGAIRGALRKGPVLAGGGALLPDVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEF7</accession>
    <name>A0A7K2ZEF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000738">
        <property type="protein sequence ID" value="MYW30716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="7955" checksum="FACB2FE0DEBB584E" modified="2021-04-07" version="1">GAIGSVTAVPAGWREACRTLAGCALPRLAGLDLIELAGLLAATEPATPGGQSRHDAHNGHGSRARPRPLDTALPSRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEW3</accession>
    <name>A0A7K2ZEW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000773">
        <property type="protein sequence ID" value="MYW30872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="18411" checksum="A29FD1DCD98E8174" modified="2021-04-07" version="1" fragment="single">MPVALITGGSKGLGRAPAEAPARQGWDLVLDARTSVVLEATAKEVRERYGRRMAAVPGDVTDAAHRAELVAAAGEPGGLDLLVSNASVLGAEPLVRLEAQPLEGFRQALETNVVAALGLVQEALPLLRASASGAVVTVSSDAAAEPYGTWGGYGASKAALDRLAAVLGVEEPGLRPWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEY2</accession>
    <name>A0A7K2ZEY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000790">
        <property type="protein sequence ID" value="MYW30911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13417" checksum="CCCA833B930C9266" modified="2021-04-07" version="1">MANTEASLKEAMSSIEGTTGVALVDYTSGMALGTLGGGKDFNLEVAAAGNTDVIRAKLRTMEHLGLKEEIEDILITLGTQYHLIRLLRTRGSNGLFLYLVLDASRANLAMARHQLKKIEAELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEZ1</accession>
    <name>A0A7K2ZEZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000800">
        <property type="protein sequence ID" value="MYW30921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="8928" checksum="2DD9339A90466A55" modified="2021-04-07" version="1" fragment="single">AGDRAAELVRTLAAEARLAHGGVVLGPLEALAPERPEGARLLASLCTAVSGTPLIAYGKKNWDPLWTRDSPVPVAVLPPGPAGAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEZ3</accession>
    <name>A0A7K2ZEZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="entry name" value="PTHR31087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="18785" checksum="5EC2862245076C93" modified="2021-04-07" version="1">MRLLVRERLFAIGDDYWIEDAEGRKVFLVDGKAMRLRDTFELKDADGRVLVELRQKLISLRDTMLIERGGEELAKVKRKRLSLLRNHYRVTLVDGTEMDVSGKILDREFAIEYDGELLAQVSRRWLTIRDTYGIDVVREDADSALLIAVAMCVIVLADKEKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFD2</accession>
    <name>A0A7K2ZFD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathionylspermidine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000836">
        <property type="protein sequence ID" value="MYW31077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSP_synth" evidence="1">
        <location>
            <begin position="12"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="302" mass="34521" checksum="6A1AEDDC4C27C404" modified="2021-04-07" version="1" fragment="single">MERRTIEPRPGWQETVESQGLVYPLTRYPDGSLRPYWDESAYYVFSLPEVEALEETVEELHTMCLAAAAHIVEQDRFADLGITDPRLASLVAESWRRRDELPSLYGRFDLRYDGGGPAKMLEYNADTPTSLVEAASPQWFWMEERFPGADQWNSLHERLVDAWKRQARLLPPGPLHFAHSDGDEAGEDLMTVAYLRETADQAGLDTHALSVEDIGWDRLSGRFVDDRLRFLRSCFKLYPWEWLTTDRFGPQVLDTLDNGGGSGTTCWIEPAWKMLLSNKALLAILWELYPGHPNLLPAYLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFP7</accession>
    <name>A0A7K2ZFP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_18175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000859">
        <property type="protein sequence ID" value="MYW31146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="165"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="239"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="321"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="464"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="724" mass="79096" checksum="4F8405E7F5BEB561" modified="2021-04-07" version="1">MSIPAQASGEQDAEPDGPEGRLRRFATIWSRAIFPLTATSLTRPEFERHLLPLARELSLTLHAHPFDASPAARIGAALVDAHCTDPDALSSTLGVVDSYLVLYCGGNGPGELSTEDARARCARIQHTLASGFSQALRERTLAEQEAIARSALTARSNAEQALHATEARFRAVFKDAAVGIGIADLDGNILEINDTLTKMFGGLEHHVRSHRVNEWVHPEDSPQVWKFYNELVRGERDHYRVEKAYYRNDGTVLWTNLTVSLLRDPEGRPQYQLALMEDTTERRLLNLRLRYEATHDALTGLPNRTLFFERLEKVLAAKDGARFGLCYLDLDGFKAINDSLGHAAGDRLLVEVADRLQSCATAPGEMVARLGGDEFVALTTGPDTADAVDELAGRILNVLATPIRLDGRELSVRGSIGIVEGPAGERSAAEVLRSADITMYRAKAAGGNRFELADAEADARAITRHGLTTALPAALDRGEFFIEYQPLVHLGDGTVHGAEALVRWCHPQHGVLGPDRFIPLAEHTGLIVPLGRWVLEESVRQANFWQERHSDGGPLRINVNLSPTQLHHPRLVAETVDVLERSGLEPGALCLEVTESALIGADDDLLKPLRQLAEMGVDIALDDFGTGYSNLANLRRLPVSVLKLDRSFTRGMQQHPADPVDLKIVEGIVSLAHSLELAVTVEGVETGAQAEQLRRLGCDTAQGWYYARPGAPDRIHSLLLADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFY8</accession>
    <name>A0A7K2ZFY8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="14">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-IPM isomerase</fullName>
            <shortName evidence="14">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">leuC</name>
        <name evidence="17" type="ORF">GT040_18705</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="14"/>
    <dbReference type="EMBL" id="WWKE01000870">
        <property type="protein sequence ID" value="MYW31250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="16">
        <location>
            <begin position="7"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW31250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="475" mass="50301" checksum="E062F86EC45ACD45" modified="2021-04-07" version="1">MGRTLAEKVWDDHVVRRAEGEPDLLFIDLHLLHEVTSPQAFDGLRQAGRPVRRLDLTIATEDHNTPTLDIDKPIADPVSRAQLETLRKNCADFGVRLHPLGDVEQGVVHVVGPQLGLTQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVDGELPEDVTAKDLILAIITRIGTGGGQGYILEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAPDETTFAYLQGRDAAPKGEEWDAAVAYWKTLRSDDDAVFDAEVVIDATELAPFVTWGTNPGQGAPLSAHVPDPASYEDASERNAAEKALEYMGLTAGQPLRDISVDTVFVGSCTNGRIEDLRNAAAILDGRKVADGVRMLVVPGSVRVALQAVSEGLDKVFTGAGAEWRHAGCSMCLGMNPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLSDTRTPAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGA8</accession>
    <name>A0A7K2ZGA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046002">
        <property type="entry name" value="DUF5958"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19383">
        <property type="entry name" value="DUF5958"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="143" mass="16020" checksum="2A1E06434211E7C2" modified="2021-04-07" version="1">MAHPYLTLNELAQELRPMAQGVEWFGSLSAEEQSDTLRLLAHFCVQARATVEDGPEAIRRAGLHVTHTPAVLIARGRIEQQLRKIAGLTPRDERLKSFRLLIAVLAVADGLGSPSQAGRNARQVPAWDLRSGPWRRCRLRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGD8</accession>
    <name>A0A7K2ZGD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000915">
        <property type="protein sequence ID" value="MYW31424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029689063" evidence="2">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="71"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="317" mass="33822" checksum="1A710C13E2CF9365" modified="2021-04-07" version="1">MPRSRHSALFALITVAALALTGCADPAEPGAGTTGNGVEKGDTPTTDVVSSVKKVDAVAELLPEDVRKAGTLRIAAATGSPPGAFYEEDGTTLSGADIDFADAAAKVLGVKLKREVASFEAILPALGSGKYDLGTGNFGVTDERRKTIDFVTYINDGQGFAVREDSPLKEITDLTDLCGLNVSTGAGTTFEVALQENLPRCAEKGKKPYEVKTYADPAAVWLSLKQKRTDVNMSTINGLRYAVTQQEGLRFLNEYKRLDVGFAFKKGSPLTPAFQAAVNELKKDGTYDRILEKWGTTESAIEKSQISPPELKGPEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGN8</accession>
    <name>A0A7K2ZGN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000936">
        <property type="protein sequence ID" value="MYW31517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="9589" checksum="8E383C1016EE7689" modified="2021-04-07" version="1">LSSIVAVGASIAERSLATPADIDLAVTTGLGYPAGPLTWGERIGAPRLLELQRALHATTGDPRHRPTRWVSERADLGLALTDAGTSVGECWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGR5</accession>
    <name>A0A7K2ZGR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000954">
        <property type="protein sequence ID" value="MYW31544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="14321" checksum="D5B635D268BCE223" modified="2021-04-07" version="1" fragment="single">ARLVAVDGRVSHEGEGIYGGQAVAAGVAAAMVGAGLASVIAAALSVVPMDSWTARSLRRAVAAAQRTYPDRLTMERAVRSAVVIGGYPWTDLAPEAVGLAFGAFTAARGDFRTAVLTAVNMGRDADTTAAVAGALAGALHGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGU5</accession>
    <name>A0A7K2ZGU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000964">
        <property type="protein sequence ID" value="MYW31562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="21100" checksum="1C53D2932EE43D73" modified="2021-04-07" version="1">MAAVVVGCAVIGLGAGALLSGGDEPGKDDKQPVASQSSPVTTPTTEAAADPGKPQAEALDKLLADSNNSRAAVISAVEKIKSCKDLDQANTDLKGAAQQRRDLVTRLEGLTLDQLPQHEALNSSLTRAWKASAAADDHYATWARQAKKNKSVCKGGQARSTNETARANQQSGEATKAKQEASKLWNAIAGKYGLTKHTPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGV7</accession>
    <name>A0A7K2ZGV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OHCU decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000955">
        <property type="protein sequence ID" value="MYW31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="2">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="88" mass="9822" checksum="5D4824E6975F5323" modified="2021-04-07" version="1">EPAPCLHHDAPRAAHLALRAAHAAYESRFGHSFVICLDALPPSQHVDQVLAGIRVRLAHEVDEERAVTTDELRRLARSRLVELVTEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHI6</accession>
    <name>A0A7K2ZHI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_21705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001021">
        <property type="protein sequence ID" value="MYW31823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="247" mass="27127" checksum="93E1CA2A0267E952" modified="2021-04-07" version="1">MAVDPLIELRDVNKHFGELHVLQDINLTVGRGEVVVVIGPSGSGKSTLCRAVNRLETIESGSILIDGKPLPAEGKGLAQLRAEVGMVFQSFNLFAHKTVLANVSLAQLKVRKRKKEEADRRSRELLERVGLASQADKFPAQLSGGQQQRVAIARALAMDPKALLFDEPTSALDPEMINEVLEVMRQLAQEGMTMVVVTHEMGFARSAANRVVFMSGGRVVEDRTPEDFFTAPESDRAKDFLSKILKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI22</accession>
    <name>A0A7K2ZI22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M6 family metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_22720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001065">
        <property type="protein sequence ID" value="MYW32010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012300">
        <property type="entry name" value="Pept_M6_InhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007519">
        <property type="entry name" value="Protease_InhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029616108" evidence="2">
        <location>
            <begin position="33"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M6" evidence="3">
        <location>
            <begin position="102"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="803" mass="87269" checksum="9585C8465D35305E" modified="2021-04-07" version="1">MTNQRRALRAAAVVVAMAATAATASTFATAQAHDTTSSSTASAAPTVDRHDPAPGKGHVEHNLEGPFSEQQAAQREAALEQVLAGDKKVTTKAGSKVVKLGDKKYVELGREKTDKIFTILLEFGDKVDDTTMFDPDGDGPKPPVKKYGGTPGPAHNEIAKPDPKKDNSTAWKADYNQAHFEKLYFGEGKNVHSLKTYYEKTSSGRYSVDGQVSDWVKVDYNEARYGSNYCGQSNCANVWDAVRDGVNAWVADQKAKGRTDAQIKANLAEYDQWDRYDYDGDGNFNEPDGYIDHFQLVHAGEDESAGGGAEGENAIWAHRWYAYGTNAGATGPADNKAGGAQIGDTGIWVGDYTVQPENGGLGVFAHEYAHDLGLPDLYDTSGGGENSVGFWSLMSAGSWLGTGKGEIGNLPGDMTSWDKLQLGWLDYDKAKAGKTSLHKLGVSEYNTKDPQALVVELPAKAVTTTVVKPAQGTKQWWSDRGDNLSNTLTRSVDLTGKSSAKLDLSGWYDIEADYDYLYTEVSDNGGTSWTPLDGTADGKAIPRDASDKPALTDVSGAYQKLSFPLDAYAGKKVDLRFRYQTDGGAGGKGFAADEITITADGATLFSDNAEDGDNGWTAKGFSRIGESFTQDYPQYYIAENRQYVSYDETLKVGPYNFGFSTTRPDWVEHYAYQTGLLVWLWDTSQKDNNTSVHPGEGLILPVDAHAKPLKWKDGSILRNKIQPFDAPFSWYPNKGFTLHNADVPLKIQPSLGNPVFDDRKGTYWYKENPTGSVKVSDTNTRISILLEPASGSSMTVLVSPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIB0</accession>
    <name>A0A7K2ZIB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_22965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001073">
        <property type="protein sequence ID" value="MYW32055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="6">
        <location>
            <begin position="94"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="770"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="814"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="814"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="964"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="990"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1085" mass="117996" checksum="5EC8E46F07295FF7" modified="2021-04-07" version="1">MRRSNEGSAVQPERGNFTPPSHAAASPAQAPEPEPASGSTSRFSPRNWRVATRLNAILLIPVIIGLIMGGFQVKGSIDTWSEAQEAEKIARVVRAASDYGQALLNERDLTAQPLLSGDRTADIVEQTRATTDRARTAFDAAVKDMPAKPGLERRLKLFKVDEPKLPELRKAAYSQALDPVKTEEGYTQVQHSLMQFANELGLGTGNVTSYGRTVYAIELSKAAESLQRSIGMHLLVRPSQKPAVYNDQVKAFGSYNYLEQIALAEFNAGGTQADVDRLKQVMAGKAAEGARQLKAAREQADAAGQPFVAPPSIDGSVFNGMVQEIGKGQEPEELAKKGITPETWMAAATAKFEGYATVEKELVDKAVDEAARISSDAKSDAIVNGLIVVIALLAAFILAGLMARQMSRAMQRLRTAAFSIAEQRLPSLVDQLSRTDPGRVDTRVQPIPITTQDEIGEVARAFDQVHREAVRLAAEQAMLRGNVNAIFTNLSRRNQSLIEGQLTLITDLENNEADPDQLESLFKLDHLATRMRRNGENLLVLSGEEPGRRWDQPVPLVDVLRAASSEVESYERIELSGVPEAEIHGRAVTDLVHLLAELLENATTFSSPQTKVRVTATRLPDGRVMVEIHDKGIGLTAEDFADINHKLANPPTVDAAVSQRMGLFVVGRLADRHGIRVQLRPSGEQAGTTSLVMLPDAITHGGSGDSLPGQGDFTVSSIIPEQQSAFDPAPQHGQMRTAAELGFDDSRYEVPADPAQLDPVNRSLMREERRAALEAQTDPGSPFPEGSQEQQGYGQEGYAQDQYAGHDAYNGQQSYAQETYGQDQYAQDSAQQAQQDPYAGSYEQQGYGTGNGYPQPEQNGSQAQPQQGYAEAAYAAPENPQDLYAADRYAAPTDQSHQDDWPVQSGSQNTFEPVRQAEAESVPSVPAPSQERVGFERPGSTPNVGHELTEAGLPRRGGAQHWQPSGRGNDQPAPAPQRQPQQQERQAPQTDGDGTDDWRSTNDERWERAEKLREPKAGGITPSGLPRRVPKANLVEGTAEQTQQGGPQVSRAPEDVRGRLSKLRRGVQRGRNAGSDTSTTYNQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIC3</accession>
    <name>A0A7K2ZIC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001081">
        <property type="protein sequence ID" value="MYW32084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="314" mass="34324" checksum="250490DDD0C4166D" modified="2021-04-07" version="1">MRLITAYNPPASPTRTRAAERAPLRVAAVQQRWHRDPAEHRAALREGIRLAAAEGARVVCLQELTLSPYFAVVRRADHPAPAAPEELLTGPTFTFAAEAARAYGVYVHASLYEKAPAPGGEDDGLGYNTAILVAPDGTLAQRTRKTHIPVTEGYYEDDWFRAGPAGDDAFPLVTVDEARFGLPTCWDQWFPELARAYSLAGADVLVYPTAIGSEPGFPGFDSQPLWQKVITGNAIANATFMIVPNRIGAERGLTFYGSSFIVDPYGRVLAQAPRDEPAVLVADLDLDARRDWLELFPFLTTRRPDAYGPLTVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIE3</accession>
    <name>A0A7K2ZIE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001081">
        <property type="protein sequence ID" value="MYW32085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="13782" checksum="9B8811942A492461" modified="2021-04-07" version="1" fragment="single">MTSRTVTLLDVARTAGVSKSTASDALQGSGRVAEATRDRVRAVAEDLGYRPNSAARRLRRSSTGAIGLHLPQTATRLDYYMNLAFGAVARAQEEGFDMVLLAPEGAAGGPVASRVDGLLVIDPEVDDRAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIP0</accession>
    <name>A0A7K2ZIP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_23805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001112">
        <property type="protein sequence ID" value="MYW32211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="304" mass="31928" checksum="4C90D0A7D3E74166" modified="2021-04-07" version="1">MTDAAIEARGLTMAYGRGGGARTALDDCSFRLPAGRVCALVGPNGAGKSTLLGLAAGLARPSAGTLTVLGSADPSAVRERLAYVPQDKPLYPQLTVADTLWAGGELNPARWDADIGRRIAAPLPPKARVRTLSGGQRTRLALALALGKRPELMLLDEPMADLDPLARHELMGVLMAETAEHGTTIVMSSHILTELEGACDFLLFVDGGRVRLGGEAEDIVSAHALVTGRTDHDLSPHTVVESRTTGRQLTALVRKEGPVDESRWAATEPSLEELLLAHLRSPDAPPLLTPSAVAGEARKAVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIQ1</accession>
    <name>A0A7K2ZIQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001114">
        <property type="protein sequence ID" value="MYW32230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7041" checksum="8E294D13EA0CBE2C" modified="2021-04-07" version="1">MKLSDVLIIIGVLGAAAGLAALLGDGWARQALLPLAGGGVAGFVGERIKDRRKRHGGGTARRPRGRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIY8</accession>
    <name>A0A7K2ZIY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001142">
        <property type="protein sequence ID" value="MYW32311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15272" checksum="7333A4505CBD3751" modified="2021-04-07" version="1">PGGQRDLGDGVWESGPGAATAARIGRAELLAAAQVDEEQLEEWESYGLIVPAPEGGYDAEMVTVARLVADLGRFGLEPRHLRAMRASADREAGLVEQLVAPLRLHRNPQTRAHAEATANELAELSVRLHAALVQSALRSRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIZ5</accession>
    <name>A0A7K2ZIZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(Fe-S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001134">
        <property type="protein sequence ID" value="MYW32297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="256" mass="27015" checksum="2394ABAB85442A40" modified="2021-04-07" version="1">MRIGLFATCLGDTLFPDAVRSTAVLLARLGHEVVFPPEQTCCGQMHINTGYQREPVPLVRNFAEQFGDASIDAVVMPSGSCAGSVRHQHAIVADRYGDAALRAGVAVVAAKTYELSELLVDVLGVTGVGAYFPHRVTYHPTCHSLRMLRVGDRPLRLLRAVDSIDLVELPGAGSCCGFGGTFALKNAETSTAMLHDKLDSIATTGAEVCTAGDSSCLMHIGGGLSRIRSGTRTLHLARILAATRATPDVLTEAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ02</accession>
    <name>A0A7K2ZJ02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001144">
        <property type="protein sequence ID" value="MYW32314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="30474" checksum="8537F00FC4C8E492" modified="2021-04-07" version="1">SAPWIVGVVSAATLLLGTAAVAGSWASGEVPGLATDGAPAPVESLAEAAQSTGSWLIGFGFILFVAGGRRAYRDASARRTIGILWDVGTFWPRAAHPFAPPCYAERAVPDLASRMCAWTATTKGRLIISGHSQGSVLAAAAVWQLPDTARRRVGLLTYGSPIERLYGRWFPAYFGAVPLLGLNRSVHCWRNLFRATDPIGGPVRLSTDPDPGVDRGPLKDPLAYGRTTALPLPEPILGHSDYQADPVFAKERAALLEELGPLLPRQGGDALEKGQEGPASQKSSGRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJP2</accession>
    <name>A0A7K2ZJP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="14"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="474"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="624" mass="65835" checksum="CE32DC7FEF76B91F" modified="2021-04-07" version="1" fragment="single">MTDVPHTGAPTSTLRLTAAQRGVWFAQRLDPADPAYNIAEYADIRGAVEPELLRRAVGHTAAEMEALRTTFGERDGVPFQRVQEGTSISVPLVDLSGEEDPQAEALRRMRLCLAEPADVSAGPLVRVTLYRLSPSHHLFHQQVHHLALDGYAAALALSRIAEVYTALVLTPDVLPELRPAGSLAALIEEEDAYLASEQGSKDETFWAGHLVGALPPQAPAPSGGSKKYGTESVRRVYGPAETARLKAAAKRAGTGWPTFVMAALALCLHREKGLGEVVLGLPVTGRRTPAARSTPAMLSSILPMRLAVSPADRVADLARRASAEARSVLRHQRRPAEALRHQLGLTGTTTALTGPSVNILAFDDALRFGPHPATLHNLSIGPVEDLAVAVHASFGDGGMHVDLLGNAARYGQQDLVGPHERLCRVLDAFVADPDRTVGAVSPVDEDEQRRVLGLGAAQPSGSEVQEPPPLTEQFARQARTTPHLTAVVCDGVTLTFEELGHRVDSLAAVLASRGARPGTRVAVGLPRSTDLVVAMLAVMRTGAAYLPLDPSYPADRLAFMIEDSRPVALVATASSAETVDPRGAVPCVDPATAPAVAAGEPAGSEPGPQDAAYVIYTSGSTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJQ6</accession>
    <name>A0A7K2ZJQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029730287" evidence="1">
        <location>
            <begin position="39"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="71"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="349" mass="37720" checksum="58FC6ED5CA59F2EB" modified="2021-04-07" version="1">MLLHRTTPVKPWRRLAAALSVATLGVGLLTGCGSDTEAKKNDDAPAAEAGAFPVTVEHAFGSTKVERAPKRVVSVGYTDDQAILAFGIKPVGMVDQYPNPVGRTPDINTQWPWVKDQWGDTRPEVIMNNGDAGPNYEKIASLRPDLIIAVYSEVDQAAYDKLSKIAPTVGRTKAEKEPFSAPWQDNAVHIAKALGKESEGKELVKGIQDKLDTAKKDNPAFAEQKAVALSWYKGAVYPFTSTDVRGQLVTGSGFGYQTEIDKIADGKFSTELSPERIDLIDVDRIFVINDKADTEALKKFKLFANLPAVKDGKVSYLLDSEGPAIGAAMSQGTLLSLPYAIDELVKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJR2</accession>
    <name>A0A7K2ZJR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001200">
        <property type="protein sequence ID" value="MYW32588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="296" mass="30346" checksum="633764ED6135E9F9" modified="2021-04-07" version="1">MTSEITLFVNPTAGRGRGAHAAQPAASALRDAGFSVRTVLGEDADDALRRAREAVAAGTGALIAVGGDGLMSLALQAVAGTTTPLGVVAVGTGNDFARALGLPIRDPAAAGALAARALKEGGHRDIDLGRAGERWFGTVLASGFDSRVNDRGNRMRFVGGRFKYDLAILAELAAFKPIPYRIRLDGGEVREIEATLIAVGNGTTYGGGMRICAEAAMDDGLFDVTVVGECSRATLLKVFPRVYKGTHLSHPAVTVHRVASIELAAAAVTAYADGEPLGALPLTATCVPGAVQVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJS0</accession>
    <name>A0A7K2ZJS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001200">
        <property type="protein sequence ID" value="MYW32584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="10013" checksum="68A41C0993F5A081" modified="2021-04-07" version="1">MNPTYLTPTAVRTGPFPVPVPAAVRFRAACPDCRGRFELAAGALRLAIGATSRTTFYTFTCPECAAPVRKPAGERIIELLTGGGVRTLRLHATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK13</accession>
    <name>A0A7K2ZK13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001200">
        <property type="protein sequence ID" value="MYW32589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="330"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="670" mass="74663" checksum="FB770915FD247237" modified="2021-04-07" version="1" fragment="single">MTEDLSPAERYQASRARAAEMATALGPFREMYEFGLDPFQIEACQALEAGKGVLVAAPTGSGKTIVGEFAVHLALEQGRKCFYTTPIKALSNQKFADLVKRYGADKVGLLTGDNSVNSEAPVVVMTTEVLRNMLYAGSQSLSGLGYVVMDEVHYLSDRFRGAVWEEVIIHLPESVTLVSLSATVSNAEEFGDWLDTVRGSTEVIVSEHRPVPLWQHVMAGRKMYDLFEEATDHGGRGAGRREVNPDLVRLARQENQQGYNPRDRRRGKMIREADRERERRQRSRIWTPGRPEVIERLDNEGLLPAITFIFSRAGCEAAVQQCMYAGLRLNDEDKRRLVREIVEERTASIPGEDLHVLGYYEWLEGLERGIAAHHAGMLPTFKEVVEELFVRGLVKAVFATETLALGINMPARSVVLEKLVKWNGEQHADITPGEYTQLTGRAGRRGIDVEGHAVVLWQRGMDPTALAGLAGTRTYPLRSSFRPSYNMAVNLVQQFGRHRSRELLETSFAQFQADKSVVGISRQVQRNEEGLEGYKEGMTCHLGDFEEYARLRRDLKDRETELAKQGAAQRRAAAASSLEKLKPGDVIHVPTGKFAGLALVLDPGLPAGRANGHRGFDHHDGPRPLVLTAERQVKRLASMDFPVPVEALDRMRVPKSFNARSPQSRRDLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK54</accession>
    <name>A0A7K2ZK54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001247">
        <property type="protein sequence ID" value="MYW32721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="10673" checksum="4CDF88A8157B81B1" modified="2021-04-07" version="1">ARARVHAERFGTETAIGEALRCVSLFAPPEEAEQLLADAVRHLERSSSAYEHALARVDYGIAIGSHRELARAQKQAMACGAEGLAARAQKARTSIRSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK87</accession>
    <name>A0A7K2ZK87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_26715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001249">
        <property type="protein sequence ID" value="MYW32766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015608805.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001249.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="10983" checksum="BB83E880CBA904D9" modified="2021-04-07" version="1">MAWVLLLVAGLLEVGWSIGMKYTEGFTRLWPSVFTGLGIVASMVLLSHAAKTLPIGTAYGVWVGIGAAGAAILGMVVLNEPVTAARIFFVCLLLVAVVGLKATSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK92</accession>
    <name>A0A7K2ZK92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplN</name>
        <name evidence="6" type="ORF">GT040_26620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966950.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001248.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZK92"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="13401" checksum="497058A10C6E3784" modified="2021-04-07" version="1">MIQQESRLRVADNTGAKEILTIRVLGGSGRRYAGIGDVIVATVKDAIPGGNVKKGDVVKAVIVRTVKERRRQDGSYIRFDENAAVILKNDGDPRGTRIFGPVGRELREKKFMKIISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKA8</accession>
    <name>A0A7K2ZKA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trypco2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001251">
        <property type="protein sequence ID" value="MYW32782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045608">
        <property type="entry name" value="Trypco2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19631">
        <property type="entry name" value="Trypco2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="12501" checksum="575970E71EE4AE32" modified="2021-04-07" version="1">MTAENSHDLDGIELADAVESIRNQLMEAADRATDRPLAFAVGDIQMEFTLELRKEAKAGGKVKAWVVEAGADASRATGRTHKVAFTLSPRNAVTGQAWAIGTEDDGSTAGFGGGDGAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKC6</accession>
    <name>A0A7K2ZKC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_26885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001253">
        <property type="protein sequence ID" value="MYW32800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="332" mass="34530" checksum="6D7679A113F4BF68" modified="2021-04-07" version="1">MDTFALIVTIGVALGFTYTNGFHDSANAIATSVSTRALTPRAALAMAAVMNLAGAFLGQGVAKTVSEGLIATPVGQKGMGILFAALVGAIIWNLVTWYFGLPSSSSHALFGGMVGAALAGGTDVIWSGVLEKVVIPMFLSPFVGLIAGYLVMVGIMWMFRNANPHKAKRGFRIAQTVSAAGMALGHGLQDAQKTMGIVVMALVIADVEGPNDEIPVWVKIACAVMLSLGTYAGGWRIMRTLGRKIIELDPPQGFAAETTGASIMFGSAFLFHAPISTTHVITSAIMGVGATKRVNAVRWGVAKNIILGWFITMPAAALVAALSYGAVLLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL12</accession>
    <name>A0A7K2ZL12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001304">
        <property type="protein sequence ID" value="MYW33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="57" mass="6166" checksum="90C0C2DBE2CC144A" modified="2021-04-07" version="1">MESLIPGVPEQRITTASAPYAWRRLLNAYGEEPPGPAPAGMRVPPPAARWRMVPTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL21</accession>
    <name>A0A7K2ZL21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_28210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001310">
        <property type="protein sequence ID" value="MYW33054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="22216" checksum="92B263F2CC86E663" modified="2021-04-07" version="1">MSFEHVGNAHSTHGAHGDDAMALKILVAGGFGAGKTTLVGAVSDIRPLRTEEPLSEAGRGVDDTDGVARKTASTVAMDFGRITIHAGLSLYLFGTPGQDRFWFLWDELSEGALAAVVLADTRRLEDCFAAVDYFERRRIPFVVAVNCFPGARTYAAHDVSHALDLDRCTPVVLCDARDRDSGKDVLIRTVEYAGRVHTARLLDAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLB6</accession>
    <name>A0A7K2ZLB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001340">
        <property type="protein sequence ID" value="MYW33145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="89" mass="9483" checksum="6DCDE4944073510C" modified="2021-04-07" version="1" fragment="single">QERLHGALLYAGRPPASSRRTVPAPADAGFGEAMVTGIAALALHGFATVPDLGALHRIDVLVPRTRRLRSTRFVEVVRATAPPPVPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLK7</accession>
    <name>A0A7K2ZLK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001355">
        <property type="protein sequence ID" value="MYW33231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="317" mass="34521" checksum="AE9CF03F449759EE" modified="2021-04-07" version="1">MAHQRSSQPRLSPSSYEEDIRAVLAPRLAYFEAVARHEHVTRAAHELGVPQSTLSRAMVRLEADLGVALFARKGRTVSLTPAGRTFLGSAERALAEVEKAADSVRADADPTAGRVSFGFLHTMGSETVPALIRGFRADHPKVRFQLVQNYGEAMIERLRAGGLDLCLTSPVPDAPDLVTRRLDEQRLRLVVPDDHRLASRRRIRLAEAADETFVTLEPGYGLRRITDDLCTEAGFTPRVAFEGEEAETLRGLVAAGLGVALLPPPAVARPGVVELTVTAPRAVREIGVAWLDGHPDTPPVAAFKRFLLSRRGNLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLL8</accession>
    <name>A0A7K2ZLL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_29255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001357">
        <property type="protein sequence ID" value="MYW33242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029859498" evidence="2">
        <location>
            <begin position="27"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="87"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="530" mass="56148" checksum="6B8309551B16975B" modified="2021-04-07" version="1">MTKRAGILVAAGATVAGLLAAAPAPAAASGTGAPPAPKLAWTDCPTENHPTLQCAKVDAPLDHADPSGRRVTLALSRIPHTAKTFQGPLLVNPGGPGGSGLSMAGFVASALPKKVASQYDVIGFDPRGVGKSTPKLNCLPGHSDPVRPDSVPASYRDERINRDRAAAFARACGEKHGDVLPYMDTVSAAKDLDVIRRALGSQQINYFGYSYGTYLGAVYAKLHPERVRRLVLDSVVGPDDVWYEGNLNQDYAFDDRHKAFAAWVAKHDATYGLGTDPAGVEAAWYRMRAAVAAQPVGGKVGASELEDTFLPGGYYNGYWPYLAEAFAAYVNDQDNEALVTAYENFGATGTGGDNSYSVYTAVQCRDAGWPRHWSDWRNDTRRIHDKAPFMAWNNTWYNAPCASWPVAPLTPVQVTNDRLPATLILQATGDAATPYAGAVSMHRKLKGSSFVVEEGGGNHGITLSGNACLDKHLTAYLTDGTVPRGRGEGEADAVCAALPDPKPLPAAKAAAQSVDNSAGSRLHGLLGPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM36</accession>
    <name>A0A7K2ZM36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001390">
        <property type="protein sequence ID" value="MYW33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515543.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001390.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="166" mass="18113" checksum="A4FE0C3485DCCF02" modified="2021-04-07" version="1">MNSDSDLQIAGDILEVQHLLQPAREHPSTVSEFVGLARSIAADRTRWAGLVRYDTTTRWYHRLQTGPGYEVWLLSWVPGQGSGRHDHGRSAGVLTVLEGELTEHTERGHQALGAGAQRAFAPGYVHEVVNDSLEPAVSLHIYYPGLTEMPMHAAQCAPTAVDVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMC2</accession>
    <name>A0A7K2ZMC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_30500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001403">
        <property type="protein sequence ID" value="MYW33482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="350"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="506" mass="54331" checksum="B5C09C46449B96E7" modified="2021-04-07" version="1" fragment="single">MSSRITDPEQLKELLGIPFTPEQTACITAPPAPQVIVAGAGSGKTTVMAARVVWLVGTGQVAPEQVLGLTFTNKAAGELAERVRRALIAAGATDPEVIDPDNPPGEPTISTYHAFAGRLLTEHGLRIGLEPSTRLLADATRYQLAAKVLREAPGPYPALTRSFPTLVSDLLALDGELSEHLVRPGKLEAYDTELLRELERAKLSNADLRKIPETAEARRSLLALTERYRTAKRSRDLLDFGDQIALSAELALTRPEVGEILRDEFRVVLLDEYQDTSVAQRLLLSALFGSGTEPGAAGHAVTAVGDPCQAIYGWRGASVANLDDFPEHFPHADGTPATRYSLSENRRSGGRLLHLANGLAEPLRAMHEGVEALRPAPGAERDGMVRCALLSTHTEEIDWLADSLAHLVRTGTPPGEIAVLCRTAGDFGQIQAALVARDIPVEVVGLAGLLHLPEVADLVAVCEVLQDPGANASLVRLLTGPRWRIGPRDLALLGRRARLLVHRAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMJ8</accession>
    <name>A0A7K2ZMJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001427">
        <property type="protein sequence ID" value="MYW33540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="18009" checksum="E19001CE097C8049" modified="2021-04-07" version="1">MTSSAPLSWSGFAAAEPVFADTVRRRFQLYKHHVLATLRADGSPRVSGLEADFRFDELLLGMMPDSRKALDLRRDPRFALHANPGPDAEMNDGDVRVSGRAVEITDPEYLARFVEDATPPEPFYLFRAELTEAVRVGLDGDELVIQSWRPGQPLRTVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMX5</accession>
    <name>A0A7K2ZMX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">GT040_31640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="212" mass="23523" checksum="7F06B82EA1E55464" modified="2021-04-07" version="1">MSQQETDGRIDVDDEGFVVDTEDCEEREAAYRARGTSRPITTVGNPVLHKECKDVTEFGDELAQLIDDMFASQKTAEGVGLAANQIGVDLKVFVYDCPDDDGKRHTGVVCNPVLEELAPEARVLDDSNEGCLSVPTAYASLARPDYAVVRGQDAQGNPIKVRGSGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMEEGTPRYETVPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMY2</accession>
    <name>A0A7K2ZMY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhs family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001439">
        <property type="protein sequence ID" value="MYW33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1752"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1863" mass="201966" checksum="79F6CA80884B80DE" modified="2021-04-07" version="1" fragment="single">MYVDTTLPKIRYLAQVLVTIAIVTMVALLASLIPGMDVAQAAEQRTEPPGVRHEKSIPGKDFVPGKQDRSSGTDRNWKAPKATWPAGKQTERIAAASARSRSAAVDAGPVSVRQADGDRTENVAGTGLVEIEVLDRKAAEQAGVNGVLFTVTPTVPLMASRARSTVDAPPSGKVQVKLNYRDFEGSFGANWGSRLELVDTATGESLTQHNDTSARQLTGEIDLPQARAGRAAQPLALAAVAQAAGSGGDYSATSLSPSGSWMGGSSSGGFSWTYPVDAPEVPGGPEPEVALGYSSQAIDGRTASTNAQSSWIAEGWDYEPGFIERRYRSCSDDQGTGANNPDQAGKTGDLCFGSDQMVMSLGGSSTELVKDDASGTWRPADDDGSKLERKTGAENGARGGEYWMLTTTDGTQYHFGLNKLPGAAAQRTNSTLTVPVAGNHAGEPCHASAFADSFCDQGWRWMLDYVVDPRGDAMSLWWSKESNHYGKNNKPAGVKYDRGAYLKNIDYGQRADKLFTQNAAARITFTVAERCIPGSGFTCAEADRTPANARHWPDTPIDQQCNAGDQCKDKNSPTFWSTKRLTKITTQVNNGGFKNVDSFTLDQSFPATGDGTSPALWLKSIERTGHGQDGTTATMPKVTFRGEQMDNRVDGFEGLEPFSRYRIHAVDTENGGTIGVTYSPQQCKRGGTMPANAHTNTLRCYPQNWTPKGALEPITDYFHKYVVTQVREEDNVTDAVAKVTSYEYLGGAAWAYDDSENTEAKRRTWSQYRGYERVRTRLGSGTDVKQLTENRYFRGMHGDKLPSGTRSVEIEDSEGGRIADRLEFQGQLREEITYASDGGAIAAATKLTPSAVKTAERKRTGTTPLQAYMVSPVKSETREHVKDTTWRRSSETTTYDSAGLPTEVEETTGSGKKVCTRIEYARNTAKHILDTESREITTTGACGAPGGKVIDETRSLYDGGAYKAAPTRGLVTEVQELNAAGDGYLTVDRTEYDIHGRETKTFDVEGDETRTTFTPTTGAVPTKQVDTDPLGHTETTEFDHRGLPTAEIDANGKRVDMRYDPLGRLLKVWDIDRNPATQSPSAEYDYTIRRDGPTIVTNRTLKDDGSYATSYEILDGLLRTRQTQDAAVGGEGRIVSDTFYDSVGRAYKSNDGYFNDQNVAPSLLTVGDDVVPSQTRAVFDGLGEESAEVTYHYGDEKLRSTTVKDGDAVTVTPPKGETVTTTYQDTDGRDTKLREYTKADLSAWQDTVYSYDDLDQLTKVTEPGGGEHTFTYDARGRQTSATDPDGGTTRFEYDRGDNLTTVVDARGNKLVTTFDKGSRPTSLREGSASGPKRVEWTYDTLGKGLPVASVRYDKDGNAYRDEVTEYDANYRPRTTRTTIPAAAGKVAGEYTYTYSYTSTGNLSWVELPKVGPMAKERLVFRYNGDDLPISISGTANYVTDVTYSKYGEILRSEAGPAGKKLFSTYFYNDFTRRTDRVVHDRSVQPGRIDDTAYSYDEAGNVTGISRTPGEGMPDGQTGTDTQCFAYDQLRRMTSAWTAREKCAADGPSKATVGGPEAYWQSYEFDASGNRTKLVEHDPAGNVAKDITRTYSYGGDAGGPNRLREITSTGADGTTRSTFGYDTAGNTTTRQNGGTTQSLAWDAEGNLESVTEPREGGGEKKTSYFYDASGERLLRTGADGATTLYLGETELTVKADGTESVQRSYAHPDGATTVRSSDGGREILLADHHGSTQTSVDMAEVGMPVTRRLLTPFGEDRGAAPSTWPGHRGFVGGTRDQDTGLTQLGARPYDPATGRFLSVDPMVDYEQPATINPYAYSNNAPATFSDPDGLFFPILIGIAARIAIQAAIRAAARRAAQIAARKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN07</accession>
    <name>A0A7K2ZN07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001445">
        <property type="protein sequence ID" value="MYW33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029564537" evidence="2">
        <location>
            <begin position="22"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="456" mass="47636" checksum="9E120576171673DA" modified="2021-04-07" version="1">MRTTLSIRRAALVFTAVGALALTGCGDGGGDGGSKKSGGGTDKGTDSAPTVTLPKLDGENISVAAVWTGPEQANFTKVLGEFEKRTGAKVTFVPAQDPIVNFLGTKIAGGQPPDVAMIPQVGAIQQAVAKKWAKPVGDEAKAQLTKNYAKVWQDLGAVDGTQYGVYFKAANKSLIWYNAAAFDNAGAAEPKTWKEFITTAETISASGVTPVSVAGADGWTLTDWFENVYLSQAGPEKYDQLAQHEIPWTDPSVKDALTTLAELFGKPELIAGGADGALQTEFPTSVTQTFTGGDQPKGAMVFEGDFVSINIAQTEAKIGTDAKVFPFPAVGADSPVVTGGDAAVALKDSKGAQALLTWLASADAAKIWAEAGGFISPNKSLDTAAYPNDVQRTMAEALVEAGDDVRFDMSDQAPQSFGGTPGKGEWKILQDFLKNPKDVAGAQRKLESEAAKAYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN44</accession>
    <name>A0A7K2ZN44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_32040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001460">
        <property type="protein sequence ID" value="MYW33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029696522" evidence="6">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="24744" checksum="BA2E15541297FDEA" modified="2021-04-07" version="1" fragment="single">MSSLALSVLLSLVSAVAYAAGAIVQERVAARGGNSSHALVRNAVWWVAVLLNGVGAVLHVVALAYGPLSLVQPLGALTIVFALPMAALFVGRRAGARAWRGALMATAGLVGLLALTGDAEPHTLGGAEQLALATATFGAVGALMLLARTLHRPVLRSAVLATAAGGAFGMASVFTKTVAMEWTSGSVRSGLPTLLVIAGLAAAGLLLSQAAYRGAGLAAPLATVTVVNPVVAAAIGITLFGEHFRQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNP0</accession>
    <name>A0A7K2ZNP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDP-glycerol glycerophosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_32575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001489">
        <property type="protein sequence ID" value="MYW33879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="396" mass="44554" checksum="5269B536F0C524EC" modified="2021-04-07" version="1">MPTRASVKRYVRRQVMRAAYRTDLHRPLDPDLAVYGAYWNRGAACNPAAIHAKARELAPHIRGVWAVSSRHRDRMPAGVPYVIEGSRPYWRAMATATYLVNNSSFPGGFTKRPGQRYLQTHHGTPLKTMGLDQRAYPELARKADFAKILAHVGQWDFSLSANPHSTEVWDRVYPGSYQRLDLGYPRNDVYFTATAEDIAKIRAELGIHADQTAILYAPTHRDYREGFVPDLDPERLAHELGPDYVVLVRAHYFYGRSAGVGGSTPTGRVRDVTAHPRVEELCLAADALITDYSSLVFDYACLDRPIVVHAPDWNTYRTTRGTYFDLLSGRPGDSPGAVTVTSDELVEVFRTGEWRSPASAALRTAFRERFCPYDDGHAAERVVRRFFAVPFAPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP14</accession>
    <name>A0A7K2ZP14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="5" type="ORF">GT040_33575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001541">
        <property type="protein sequence ID" value="MYW34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="262" mass="27017" checksum="D4615B3C5B83E025" modified="2021-04-07" version="1">MSVRATARLRAEPDGRGSTALPLLESAGPLALRRTRSPLPTHARVTVVGAMSAPLNGDRIAIEAEVADGARLTVDAAAATIALPGPRAATGPSTYAIHLNVGEGATLHWLPEQLVSAHGSDLHQTTRVELAPTARLLLREEQILGRHGEPTGALTTRLTVRRAGRPLLDQQLAYGPGAPGGWDGPAVLGGHRAVGQLLLADPSFEDAPLPARLLGPTAARTPLAGPAVLVTAVAADARLLREILDGALHELLDGLKADTGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP31</accession>
    <name>A0A7K2ZP31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">M28 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_33675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029710499" evidence="5">
        <location>
            <begin position="34"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="6">
        <location>
            <begin position="326"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="445" mass="46042" checksum="3F9CC113956E2593" modified="2021-04-07" version="1">MRPNRLTLRRSPAAVAAVALAALLGTAAPTAQAAPATTTATAAVAAPDVPLAGVKGHLTQFSTIAANNGGNRAHGRPGYKASVDYVKAKLDAAGYTTSIQQFTSSGATGYNLIADWPGGDPNKVVFAGAHLDSVSSGAGINDNASGSAAVLETALAVSRAGYQPDKHLRFAWWGAEELGLIGSKYYVNNLPAAERSKISGYLNFDMIGSPNAGYFVYDDDPVIEKTFKDYFAGIGVPTEIETEGDGRSDHAPFKSAGVPVGGLFTGASRTKTAAQVQKWGGTQGQAFDRCYHSSCDTTANINDTALDRNSDAAAHAIWTLSAGSTGEPPTGTVFSNDTDVAIPDAGAAVTSSVTVSGRTGNAPAALQVGVDIKHTYRGDLVIDLLAPDGAAFRLKNSSSGDSADNVITTYTVNASAKAANGVWKLRVQDIARQDTGYIDSWKLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPI0</accession>
    <name>A0A7K2ZPI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1768 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_34515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001585">
        <property type="protein sequence ID" value="MYW34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="36"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="20229" checksum="9D6C04E24FDF2E14" modified="2021-04-07" version="1">MGPIDELLADVARGRRVKYLPFWGHRPRPDGRLGPSCLSQWWPSPFTVDGVTYASAEHWMMAGKARLFGDTEAERAAVTASSPAAAKKAGRLVRGFDEDLWIRERFALVVEGSAHKFGQDPELAGYLLSTGDRVLVEASPLDRIWGIGLAADDERVERPQEWRGLNLLGFALMEARERLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPJ2</accession>
    <name>A0A7K2ZPJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_34555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001585">
        <property type="protein sequence ID" value="MYW34260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029734110" evidence="5">
        <location>
            <begin position="37"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="181"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="274"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="608" mass="62710" checksum="60DC2F659F367FEC" modified="2021-04-07" version="1">MERTGPTVRFSGLLATCTAAVLAAGALVATAPAANAADVDVARNGTFEAGLDGWSCTAGSGSVVSTPVHGGTKALKGTPAGNDNAKCSQAVTVKPNSRYTLSAWVQGSPVYLGATGTGTTDVSTWTQSTGAWKQLTTSFTTGPSTTSVSVYTHGWYGTPAHYVDDLTLVGPGGDPVVVPAVPAGLGTTAITSSSVALSWNAVSGATGYNVYRGGTKVASATGPSATVTGLTASTAYSFQVTATNAAGESAKSAAVTATTTAGGGGGGDTKLPARALVGYLHSSFANGSGYTRMADVPASWDVINLAFGEPTSVTSGDIRFSLCPVAECPNVESEAEFKAAIKAKQAAGKKVLISIGGQNGQVQLASTAARDAFVTSVSKIIDTYGLDGLDIDFEGHSLSLNTGDTDFRAPTSPVIVNLISAVKTLKAKYGSGFVLTMAPETFFVQLGYQFYGSGPWGGQDPRAGAYLPVIHALRDDLTLLHVQDYNSGPIMGLDNQYHSMGGADFHIAMTDMLLAGFPVAGNTSRVFPGLRPDQVAIGLPASTNAGNGHTSPAEVNKALNCLIKKTDCGSYQTHGTWTDLRGLMTWSINWDRFNNWEFSRNFNSYFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPN6</accession>
    <name>A0A7K2ZPN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001593">
        <property type="protein sequence ID" value="MYW34326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="20329" checksum="6DFBC3FA024E9482" modified="2021-04-07" version="1">MSERHALTRRIRRWLVFFIVCLVLSGITAFPLVTELRWAEDLLSASASPVPEHLPSLMEWITRVREGLDTIERDQPFMLYGTDWLAFAHLVIAVAFYGPYRDPVRNIWVIEFGMIACAGIIPLALICGPIRDIPFWWSVIDMSFGVFGVIPLLIVRRMIKRLEVLEQAPVLATPVAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPS7</accession>
    <name>A0A7K2ZPS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001604">
        <property type="protein sequence ID" value="MYW34374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14500" checksum="3A10D2F3325616D5" modified="2021-04-07" version="1" fragment="single">MYHTWMRFFTPSPLHHRLGLVCLGVGLQHGALPTVGPRTLDHHVAVIVNSGTGWFAGPDGRRTPVTGPTLIWLTPGTPHHYGADPGTGWDESFVDFTGPATTTYTELGCIEPDRPLVPLSDTAAPRAAVGRIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPY3</accession>
    <name>A0A7K2ZPY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_35460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001623">
        <property type="protein sequence ID" value="MYW34434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="609" mass="63977" checksum="1E36DF032A84DD40" modified="2021-04-07" version="1">MTTTQTTTTVTAPAPTAPTTRGPLTLPPHTARATATAGGALTVVSAFLAWTWTSAFPGDLTVYGYPGGLQWLVLVSGALLALFGLSSYGIKGLGWLTPQGADPAIRLASYAALATAWFSIIAISVSLGGVVNLEPGAYVALVATLISWIGARSLPYERPENHPADPEDSGFEQFKHNLSNRWTTYKSAFATDGARPAKPLPSYIEILIVAVVLALGLVVFTYGISTEYDELFIGFLITAGFGFAAIQKAGLIQRVTTLTARHRNVTLVGAFVAAAAFPFTQSDDQYATIGVNILIFATVALGLNIVVGLAGLLDLGYVAFLGVGAYAAALVSGSPTSPLGIHLPFWQAILVGAAASMVFGVLIGAPTLRLRGDYLAIVTLGFGEIFRIAVLNLDGTSGPDVTNGSNGISSIPNLSLFGFDFGATHTIGGFTIGRFANYFFLMLLVTLIVVVVFRRSAESRIGRAWVAIREDETAAEAMGINGFRTKLIAFALGATLAGLAGAVQAHVTYTVTPEQYQFAHAVPPNSAFLLAAVVLGGMGTISGPLIGGALLFLIPNKLQFMSDFQLLAFGLALVLLMRFRPEGLIANRRQQLEFHEKDEAPATLTKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ23</accession>
    <name>A0A7K2ZQ23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RyR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001627">
        <property type="protein sequence ID" value="MYW34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RyR" evidence="1">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="13338" checksum="77E0602D0476019A" modified="2021-04-07" version="1">MSDQPIADIARVCHDANRAWQMATGDPAVSPPWDEAPEWQRESAVDGVRQAQKGATAEQLHQSWCDFKAADGWVYGPAKDEAQKTHPCLVPYSELPVEQLRKDDLFAAIVAALTTKEPHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQU3</accession>
    <name>A0A7K2ZQU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001682">
        <property type="protein sequence ID" value="MYW34741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="6073" checksum="0FAFB13D8E1E1267" modified="2021-04-07" version="1">ATAVEPELTTVRLPAEQVGERGMEALLAVLEGRPAEPGSLPVRLVVRGSTAPPPAASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQW3</accession>
    <name>A0A7K2ZQW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_36975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003968183.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001681.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="25101" checksum="5D038A2967C48F65" modified="2021-04-07" version="1">MTRVLVVEDEESFSDALSYMLRKEGFEVAIAATGPDGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRSRSNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRGEPEEVTPAALEAGPVRMDVDRHVVTVSGGKVDLPLKEFDLLEMLLRNAGRVLTRMQLIDRVWGADYVGDTKTLDVHVKRLRAKIEPDPGAPRYLVTVRGLGYKFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR39</accession>
    <name>A0A7K2ZR39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001695">
        <property type="protein sequence ID" value="MYW34822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16406" checksum="441055BB4DD97BAA" modified="2021-04-07" version="1">MLAGSRHETTVWAVQPVDVRRPSTGVRTAEMVCDSCGDVIEVRVSSAEIARRHRMRWLALTIAELSLTALAAAMTIRSVEADFSSRSTGGLGPQTYFWTLTTSLLTAGGSLLFRQWKREDGVRGPGDDWRTFLYRGRSSNQHNLLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRL0</accession>
    <name>A0A7K2ZRL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001733">
        <property type="protein sequence ID" value="MYW34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="5778" checksum="9372686FFCCBF84E" modified="2021-04-07" version="1">AERADVDRVTAAARAALGAAAFSEAYERGARLDPEEAGRQARTAPTAPGGVRPIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRM9</accession>
    <name>A0A7K2ZRM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RloB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001757">
        <property type="protein sequence ID" value="MYW35041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025591">
        <property type="entry name" value="RloB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13707">
        <property type="entry name" value="RloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="22473" checksum="0A8158398C6933C8" modified="2021-04-07" version="1">MASKFRSTKTTRRRAGAAHREIKKRLLVVCGGARTEKDYLEALKDHYRVSTVTVKVRTETRSPLHVVNTAADLFADAKDDFDECWAVFDVDDFDVAESIRVARRRDVSLAISNPCFEYWLLLHFCKHVGHLAEYKAVRDKIKAHLPNYDKAGIRIGDYLGGVNDAVDRARKRDENQTPPGINPNTAVWKIVKQMISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS51</accession>
    <name>A0A7K2ZS51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_29965</name>
        <name evidence="6" type="ORF">GT040_39495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001386">
        <property type="protein sequence ID" value="MYW33378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001789">
        <property type="protein sequence ID" value="MYW35201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033595501" evidence="4">
        <location>
            <begin position="47"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW35201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="307" mass="32505" checksum="10DF3DB7C2B1FC11" modified="2021-04-07" version="1">MQQHLLARRQAPRPSRSRTLTGLLTAAAATAGLLLTGLAPGAQAVAANPYERGPAPTNASIEASRGSYATSQTSVSSLAVSGFGGGTIYYPTSTADGTFGAVVISPGFTAYQSSIAWLGPRLASQGFVVFTIDTNTTLDQPDSRGRQLLSALDYLTQRSSVRTRVDASRLGVMGHSMGGGGSLEAAKSRTSLKAAIPLTGWNTDKTWPELRTPTLVVGADGDTVAPVATHSKPFYESLPGSLDKAYLELRGASHFTPNSSDTTIAKYSLSWLKRFIDNDTRYEQFLCPIPRPSLTIAEYRGTCPHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSS0</accession>
    <name>A0A7K2ZSS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_40690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001848">
        <property type="protein sequence ID" value="MYW35421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="268" mass="27349" checksum="D27EB7C72A664A85" modified="2021-04-07" version="1">MSSPSSEIFRRGVQIQKRTLIAWSAALVLLALSVVGAWPSMESSGALEDFSTGLSPELAAALGVDQIASASGYLKGNLYAVLLPLLLGLMAVTATAALTGGDEEAGRLELLLALPVARRQVFLVRFLCVASGLALTSVLVWLSVYGSVVSYDMDVSTGGVAAVTLTVALLAVLHAGIAYAIVGFGLGRGPALGVAAGVLVVGYLLHGIAPMSDALEPLANLSPWEWALGSDPLVNGVPWGGVALLVAVSAVVVAAGTYAVDRRDIKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSU8</accession>
    <name>A0A7K2ZSU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001840">
        <property type="protein sequence ID" value="MYW35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="106"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="311" mass="32542" checksum="426A2CA16053598B" modified="2021-04-07" version="1">MITGLAVLMAGVVGLHGVIPNSLGRMGSLVESFLPWCGVVVVLLFVVALSRRSGVGLVALLLPVGAWVHSFGGLLLPPTDVGARELVVVQHNVSDENPDPAGTARALLAAGGDLVALEELVGPALAVYEDVLGADYPHHVVRGTVGLWSKYPIREDQLVDIRPRAFEAGWSRGLRAVVRTPYGDVAAYVAHLPSVRVGVRGLASSPRDESARMLGDIVRGEKVGAVILMGDLNSTVDDRGLHPLTSQLNVAERGFAFSYPAALPVARIDQILARSAGVSHVRTLPATGSDHLPVAARVTLGPLPPSGRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z622</accession>
    <name>A0A7K2Z622_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_00530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000015">
        <property type="protein sequence ID" value="MYW27795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW27795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="390" mass="41512" checksum="AD51C86D20530C3C" modified="2021-04-07" version="1">MSDRAPQPVERRLPTEESRQLVALVRDIVSKEIAPRAAEEEDAGHFPREVFTLLSESGLLGLPYGSAHGGGDQPYEVYLQVLEELAAARLTVGLGVSVHSLACHALAGYGTEEQQAAHLPAMLSGGLLGAYCLSEPASGSDAASLRTKAVRDGEDWVITGTKAWITHGGVADFYTVLARTGVDGPRGITAFLVPGDAEGLNAALPEKKMGMKGSPTAQLNFDGVRVGDDRRIGAEGQGFAIALSALDSGRLGIAACAIGVAQAALDEAVRYATDRRQFGRPIADFQGLRFMLADMATQIEAGRALYLEAARLRDAGETFSRQAAMAKLFCTDAAMRVTTDAVQVLGGYGYTLDFPVERLMREAKVLQIVEGTNQIQRMVIARHLAGPETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6D1</accession>
    <name>A0A7K2Z6D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shikimate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_01060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000053">
        <property type="protein sequence ID" value="MYW27896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="4">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="28864" checksum="000610EB0067095C" modified="2021-04-07" version="1">MPSADAHRAAVLGSPIAHSLSPVLHRAAYAELGLDDWSYDRFEVDEEALPGFIEGLDRSWAGLSLTMPLKRAIIPLLDEVSPTAASVEAVNTVVFTEDGRRTGDNTDIPGMIAALRERGVEKVESAAVLGAGATASSALAALAVICAGPVTVYVRSRERGDEMRGWGQRLGVDVRVADWAEGAGALEAPLVIATTPAGTTDSVAADVPQSPGILFDVLYEPWPTALASAWSARGGAVVGGLDLLVHQALLQVEQMTGRRPAPLAAMRQAGEAALAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6I7</accession>
    <name>A0A7K2Z6I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_01370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000060">
        <property type="protein sequence ID" value="MYW27955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513504.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000060.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="27756" checksum="B0DCD2E3E38812FB" modified="2021-04-07" version="1">MATLEIRALSVGYGPVRALRDISVDVPDGAITAVLGGNGAGKTTLLRAVSRTLGFHRGTGTGTIRFDGRPLEGLRPAQVVAAGVVQVPEGRQVFARMTVADNLRAGALGARGGRKRTSAALARVHELFPVLSDRAHQRAGLLSGGEQQMLAMGRALMAGPRLLLLDEPSLGLAPLMAARIAETVQEINASGTSVMLVEQNAAIALRLASTAYVLDVGEVALHGPADELAASDEVRRRYLGVVDEEAAADADVASRNRRTLSRWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6M8</accession>
    <name>A0A7K2Z6M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000066">
        <property type="protein sequence ID" value="MYW27990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="457" mass="49427" checksum="D8D45C45B842DED7" modified="2021-04-07" version="1">MTTVGIADHNRAVVLGASMAGLLAARVLADSYTEVLVVERDGLEDLTGPDGSAETRRGVPQGRHVHALLARGRHILEELFPGFTDELVTAGAITGDVTGNVRWIMDGHRMPKPHSDMLLLSMSRPFLEQRVRARVRSLPNVRFLERHDVTGLLTAESGRGDGKAVVGVSVTEDGTDRTLSADLVVDAGGRRSRTPAWLKELGYAEVPEDQMAISVGYATQFYRLPDDVMPDEISIDVVASPQLPRGAICAKIDRDRTVVTAYGYLGDYPPSTSAGFLDFLKSLSGTDIYDAVRDHRPLGDPVAYRFPANLRRRYERLPALPDGLLVLGDAVCSFNPVYGQGMTVAALGATVLRDHVTGPQAPDPRAYFADLAARAVDDVWEMTTGADLAFPGVEGERTEEWQAEQGYVADLLTAATRDHSLLTAYARVVFLVDPPSALAAPEIQEAVRAALASQTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6W1</accession>
    <name>A0A7K2Z6W1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lepB</name>
        <name evidence="8" type="ORF">GT040_02060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="WWKE01000098">
        <property type="protein sequence ID" value="MYW28087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="37"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="37210" checksum="F02B9EE3EAA1A58D" modified="2021-04-07" version="1">LPTGSRPTTPRSLPTRAERRRLAKKVRRKRRRSAVKEIPVLIVLALLIALVLKTFLVQAFVIPSGSMEQTIKIGDRVLVDKLTPNFGSKPQRGDVVVFKDPGGWLQQENAADKEDPPIGVKQATEALKFIGLLPSDDEQDLIKRVVAVGGDTVKCCGTDGRVTVNGVPLNEPYLHPDDRPSAVQFEVEVPTGRLFMMGDHRSNSADSRFHLDEPDRGTVSEEEVVGRAVVIAWPFSNWTTLEERETFAAVTRASGSEAAVPGPSHRVATPDRDGMVRLPTPAELPLVMGVVGLHRIGRGQWHVLRSGCGGFGGRRTIRTRRTRGPAGARRVSRGRGGGAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z754</accession>
    <name>A0A7K2Z754_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4180 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000105">
        <property type="protein sequence ID" value="MYW28148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025438">
        <property type="entry name" value="DUF4180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13788">
        <property type="entry name" value="DUF4180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4180" evidence="1">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="12936" checksum="26E1C88C37A05C03" modified="2021-04-07" version="1">MPDLLVDHHGTAVLACSTDGPSIATVQDALDQLIGPAFQGAEVVAVPAERLDDRFFDLSTGVAGAILQKFSNYRLRLVVIGDITRHLAASSALPDLVREANQGRDIWFVADLDALAARLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7D9</accession>
    <name>A0A7K2Z7D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_02790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000118">
        <property type="protein sequence ID" value="MYW28225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="43"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="22279" checksum="CD10E0B3A83FFFD7" modified="2021-04-07" version="1" fragment="single">MTPPEPASLSAPVKTTAPHDTGALRSLLPVLGAHRVTVLRTCLAALVDQAALVALVTLAAHTVGIAVIEHRAPSPTTVAVLIGLVLLRALATWREMDLSHDLAYRVLAELRVRVFDGLARSAPARIAGRRSGDLAATALGDVEALEFFYAHAIAQLLASGLVFAVAATLLGVLGPWLLLAVVPAALLLLWSPLLEARGRAERGARTRAALADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7F4</accession>
    <name>A0A7K2Z7F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_03035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000143">
        <property type="protein sequence ID" value="MYW28274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="365" mass="40446" checksum="2772B8C9E777D229" modified="2021-04-07" version="1">MTTDQSETVRTGTDVVLEARGVTKHFPLRRTARDLFARERRSVHAVDDVSLRLRRGTVTALVGESGSGKSTVARLLAQLYPLTSGEIRLGGKPVVAGRGRSFRRYVRRVQLIFQDPFASLNPVHTVRYHLTRALKIHDRAGNGDKELEQALTDLLNRVQLTPPHQYLDKFPHELSGGQRQRVAIARALGADPQVLLADEPVSMLDVSIRLGVLNLLRDLKERLHLAILYITHDIASARYFADTTLVMYAGRIVEGGDSERVTQRPAHPYTQLLIASAPDPDRIVAEEEQEETGTGEPPSLIAPPAGCRFHPRCPKAMERCRTELPPRFDLADGQWAACWLYEGVGARSYENEGTGAVAAGKEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7L6</accession>
    <name>A0A7K2Z7L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7045" checksum="A74C17780433F0A9" modified="2021-04-07" version="1">MEQEACGWLIATVTAVNSGGTVDIATSRGPVEAVRRLKSYAAPAVGDRVKVDFKPDGNWIVVDALAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7R6</accession>
    <name>A0A7K2Z7R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000153">
        <property type="protein sequence ID" value="MYW28394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="158" mass="15864" checksum="1E45292E4193FCC7" modified="2021-04-07" version="1">MVNNAGISVLGPIAELPDPEVDRDLAVNVRVVFLACRAADRLADGGRVISVGTALSRYGGGPGSTLYGMSKSALIGLTKPLARELGPRGITVNLVQPGPVDTDLDPAGGPFAEGQRAVMALGRLGTADEVASLVAYLASADAGFITGAEVVVDGGHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7X6</accession>
    <name>A0A7K2Z7X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000174">
        <property type="protein sequence ID" value="MYW28459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="449" mass="48160" checksum="A07C18FAAD141182" modified="2021-04-07" version="1">MEPNVLLESLIDEAGMSRAGLAGHVNRAGRARGLSLRYEHTAVSRWLKGQRPRGQVPDLICEVLGGRLGRPVVLDDIGMGVPGGYGTDTAPHSAALSGFVERATALWRSDEQQRPHLATVPAVTGTTAVMPVWEWENPPEDTDVSRPGPGRVSAADIETLRSARDHYEQMYRKAGGIATRPRIVRFLNAEAAPLLRGGYSDELGRRLHRATAALVAMAGICAYDSDAHGLAQRYFHQALRLAKSSGDRALGGYVIALLVTQSLFLGDHRRSIAFAEAALRAAGDHITPALAADLHAMQAKAYAQLGDAASARACIRRAEAQAGRIHTGREPDETGYVQPGLVDVQVAEALLSLGDLPAAREHAASAVRAPAHDRGRVHRLAMLSHIELLQGEPERAAGTAAEMAERARGMESQRLRDRLRQVRRELAESGCADAVQTAGLIDGALRVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Y1</accession>
    <name>A0A7K2Z7Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000159">
        <property type="protein sequence ID" value="MYW28418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="145" mass="15350" checksum="FC0941A1396D6FE8" modified="2021-04-07" version="1">MAEVSAEARMEAPAGKVWAQLTDFSSYGEWNATHTSFPKGGPAPLELGASYEENMKLMGFPAEVVWTVDELEDGRLLTTRGKGPMGVNLAMRYTLAPAQDGGATTVRIEGEFTGAAVSLMGGKLKDSATAALQESLRKLDGLVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8L8</accession>
    <name>A0A7K2Z8L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000233">
        <property type="protein sequence ID" value="MYW28668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14251" checksum="E01DDBDE911BDA1D" modified="2021-04-07" version="1">MAGVAKGVPTIYPTLLYDDAKAAIRTLTQGFGFTEEAVYEDEGGGVVHAELSCGNGRVMLGSKGRDGVFARAMAGAGPAGVYVVVDGVDEHFARARDFGVEILMEPTDQDYGSRDYMARDAEGNVWSFGTYAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8M5</accession>
    <name>A0A7K2Z8M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000247">
        <property type="protein sequence ID" value="MYW28709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="380" mass="41799" checksum="B6887D44320B2647" modified="2021-04-07" version="1">MASGRTVGAVEEHWTVGRVAELAGVSVRTLHHYDEIGLVRPSAQTAAGYRAYAAGDVERLREVLAYRRRGFGPREIAELVDDPSADAVAHLHRLRGLLLERRDRADAMVTAIDRELRTRARGLKVTPEEQLEVLGAQLYDVIGDAYRATRRTDPRIAAQIWDALGDARTVLNVGAGTGPYEPADRQVTAVEPSAVMRGQRPPGSAPCVDAAAESLPFADGSFDVAMAISTVHHWGDPIGGLREMRRVDRRVVVLTFDTDEPGWQERFWLTRDYLPEFTGVLAKFPSLTGMTDAIGARAEPVLVPWDCADGLFEAYWRRPGAYLEERVRRAMSVWTRVGPEAEERAVRSLGDDLASGRRAERNGDLAGLDAADLGLRLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8T1</accession>
    <name>A0A7K2Z8T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1707 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000249">
        <property type="protein sequence ID" value="MYW28733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="121"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="235" mass="25182" checksum="468C064AA24BDEBD" modified="2021-04-07" version="1">MDLEKQPQQPARPAAPPAQVSPAEAAPGDSIRASDADRDRIADILREAMAEGRLTADEHAERVDLVYRAKTVGELQPLVRDLPAASSGAAPGPGPQPYAYGPEPQDGPTDNLVAIFSSATRKGRWRVGPRTNAFSLFGSVEIDLTEALFSQRLTVINATAIFGSVEIRVPENVTLRGSGTGVLGDFDVRTLESMDPEAPVVVVNGYAVLGSVEAKPKRGKFVTDLQRRLRKHLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8W7</accession>
    <name>A0A7K2Z8W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000254">
        <property type="protein sequence ID" value="MYW28791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="46" mass="5189" checksum="DC4D723203FCF2FC" modified="2021-04-07" version="1">AYLHERDGDLERAAQLYAEAARKAPNLAERDHLTRQAARLNSGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8X8</accession>
    <name>A0A7K2Z8X8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rplV</name>
        <name evidence="12" type="ORF">GT040_05730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000252">
        <property type="protein sequence ID" value="MYW28783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004571827.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000252.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2Z8X8"/>
    <dbReference type="GeneID" id="63982129"/>
    <dbReference type="GeneID" id="66955245"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW28783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12720" checksum="5327BDC40A3DB652" modified="2021-04-07" version="1">MEARAQARYIRVTPMKARRVVDLIRGMDATEAQAVLRFAPQAASVPVGKVLDSAIANAAHNYDHTDASSLVISEAYVDEGPTLKRFRPRAQGRAYRIRKRTSHITVVVSSKEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z905</accession>
    <name>A0A7K2Z905_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_05690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000252">
        <property type="protein sequence ID" value="MYW28775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029917004" evidence="3">
        <location>
            <begin position="18"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="411" mass="44479" checksum="B5C118615A46BEA7" modified="2021-04-07" version="1" fragment="single">MPRRTLLLTATATAALAGCAVPAPRRRGPVPDPAPGLAIASTRRALVMQLLAHPDDDLYFMNPDTRQALDAGTPLVCVYLTAGEADGVNKVPGAPRPAPDRAAYSSSRHQGLRQAYAELLGLDRFTPWETSVLPLHGGHRAERDVLADGARRVELVFLNTAMHTGRGRLGLPSLWQDRRLVLRTVVADDSPLDRAGSYTYDGLVEVLTGLLEQYRPTLVHTLDPDPDLQFSSEYERRRDSEQRGYSDHADHTAAGCFAWAALIHWVARATAAGEPVPGFTVSSFRGYYNRHWPKNLPPEVLERKAAHLVPYGGSPDWECGNPSGCGDYNVGGDRPLTNRKGWVRSTHHRYPGPRPTLSSGADGRLTAYGVLGLRAVRWRESAPGSGVWDAPDDLGGGPLAPVLGSAMTADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z919</accession>
    <name>A0A7K2Z919_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000260">
        <property type="protein sequence ID" value="MYW28837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029539073" evidence="2">
        <location>
            <begin position="33"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="20255" checksum="6E446A10A71E9896" modified="2021-04-07" version="1">MTRRLHTGRRAATAVLGLSLLLALAGCGDAGADADGKASVPEGWSTLDTDSLSVGYPKDEGYAEQPAAEGSRSNAAVALKMEDGIRTGMVSVQLNFATGVSDAAEAAAAAGAGIGLGATRKATEDVRLAGPSTARDARRIDYDFTADGKEDTPTRGTPMTGVLVAGVDSGGVPFVVRLNAVRDAVDGEDLDAFVASITVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z954</accession>
    <name>A0A7K2Z954_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_06160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000272">
        <property type="protein sequence ID" value="MYW28866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="3">
        <location>
            <begin position="30"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_DH" evidence="2">
        <location>
            <begin position="397"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="912" mass="94666" checksum="5BB55B24F69CB7B4" modified="2021-04-07" version="1" fragment="single">LAALDALAEGAASPQVVRGSAAEPGRTAFLFTGQGAQRAGMGRELHAEFPVFAEAFDAVCAAIDPHLDRSLRELVFAGEDDPDAALLHRTRYTQPALFAVEVALFRLAEHQGLAPDLLAGHSVGELAAAHVAGVLSLDDAAALVAARGRLMEEARSDGAMLAIQAGPDEVVATFGADADAVSLAAVNGPRSVVVAGDEAVVERIETEWRERGHRVRRLRVSHAFHSPHMDGILEEFRTVARSLTFHAPTVPVVSTVTGAPAAPELLRSPDYWVDQIRATVRFHDTVRSLYDEGATLFVELGPDAVLTAMARESLTDAGAEAATTCVALARAGRPEADTYTAALATVQAAGAAFDLAARYPGAERIGLPTYAFHGTHYWLAPGARTDVPGLGLDASGHPLLGASVEVAGGDGETVLTGLLSLRAHPWLADHVVAGSTLLPATAFLELAFAAGEPTGADTVDDLTLEAPLALTGRDSVRVQIKVAAPDADGARPFAIHSRPVGASGQPWTRHATGLLSAATEAAATSEALSPDADQGSWPPAGAVALPTEDVYRELDGLGYAYGPAFQGVRAVWRLGDELLAEIALPEGQQEHSGRYGVHPALFDAALHPLLPGAAEGGSPAEIRLPFAWDGVRLHAAGAASARVRITPAGPDTVSLAVTDRAGEPVVTVASLTLRPVARAAFAEAAVVREPLHVLDWPVVAAGEVPEWTRTELTGPAGLSAQDPAAVEPADLVVLNLTQVPAETRGDVPGTARTTTAYAAAFLREWLEAERFERSRLVLVTSGAVAAAPGEDVTGLVHAPLWGLVRSAQTEHPGRIVLVDLDGHGDADALVAGAVATGEPQIAVRDGEFRAPRLARAAARTTPPVRFAAEGTVLISGGTGGLGAVLARHLITEHGARRLLLLSRRGPDSPGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9B6</accession>
    <name>A0A7K2Z9B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000299">
        <property type="protein sequence ID" value="MYW28936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9238" checksum="390FDE49C1E23373" modified="2021-04-07" version="1">MSHGPALTWFKSSYSGNTGEACIEVAYGWRKSSYSNNEGEACVEVATCPHTVHIRDSKVTDGPTFAVAPGAWTAFLDHATVTTTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9I9</accession>
    <name>A0A7K2Z9I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000302">
        <property type="protein sequence ID" value="MYW28962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="45" mass="4600" checksum="FF0FD4FA4AFB4390" modified="2021-04-07" version="1">ALALRRIGAAHRESGRDHPALARELTRHGGAAGSPEGVAGLDLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9N1</accession>
    <name>A0A7K2Z9N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000318">
        <property type="protein sequence ID" value="MYW29049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="17697" checksum="073F51C61DDA4B11" modified="2021-04-07" version="1">MTWTVTAERFDSPDATALRRDYYDEVASRYWQRPATAAEMAEGLADDGADLLAPPTGQFVVGRHEGKAASCAGLVLTEEAAPGSAELTRVYVRPAFRSTGGGGLLLAAIEEEARALGVRLLRLDTRLDLVEARGLYAKHGYGEVPAFHRRNPYAEVWFAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA51</accession>
    <name>A0A7K2ZA51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YhfX family PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000365">
        <property type="protein sequence ID" value="MYW29213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="34"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="387" mass="40681" checksum="546058711EE5AB90" modified="2021-04-07" version="1">MFLDTVLHRNPGLVDAAAGLHDRGDIPPDTYVMDLDAVEENAALLAGEAERVGVGLWFVVKQLGRNPELIRAVARHIPRAAAIDVGEARTLRSAGALLGNVGHLSQIPRRALPGILAHRPDHVTVFDLANARAVADAARAAGRRQDVMIRIEGAEGTVYPGQEGGVPLEHLDAFAEAAEDLDSVRIAGVTAFPCVLCDPATGLPTATPTFDLLVKAREVLAARGHRDLVLSAPSATSAASLPLLAERGATHGEPGHALTGTTPLHALDPTQPEKPAYVYVTEVAHTLDDGRPALFGGGFYARSHIRSALLPRTGARLGVQEAPARNIDYYRLLDAPAAGTDVRAGDTALLAFRTQIFVTRSTVAVVSGLSSGTPRLSGLYDAQGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAV3</accession>
    <name>A0A7K2ZAV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000432">
        <property type="protein sequence ID" value="MYW29497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029665552" evidence="2">
        <location>
            <begin position="31"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="183" mass="17033" checksum="BAFF098E6886DB7E" modified="2021-04-07" version="1" fragment="single">MVVTTGPVPQRLAVTTIVARAVTTAGRPVAAPEAVSAAMTATATGIVGRVVMTTGAVAPVVVSVAMTIGAVAPAVGSGVTTTVVVASVAMTVVVAAPAAGSVVMMTVVAVPAVAASSGVTIGRVGRVGTTTVPAAAASPVMTVAARPGVASVAMTTAAAAPVVASAVTIVVAVPLVVGSSGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAX1</accession>
    <name>A0A7K2ZAX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000425">
        <property type="protein sequence ID" value="MYW29489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="257" mass="27582" checksum="1500820D49CF6443" modified="2021-04-07" version="1" fragment="single">MKTERTPRTEAAESTRPSSPDAPDPRTTDPGPESTDHRPAHRRDLIAAAAAVLLVTAAILIGRYVQNRTGTLQVQWPPLLASWDPHLGPGTPAALTMAALVVAYGPPLATRLPWRGLLAAAWAGSTAWVFSMALIDGWYRGVERRLTTKHEYLRVIDRFDDIPATLRDFTNHIVIGEPGNWPAHVAGHPPGATLTFVWLDRIGLGGGAWAAVWCVVVGSSAVLAALITVRVLADERLARRAAPFLVLAPAAVWAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB19</accession>
    <name>A0A7K2ZB19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PaaI family thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000448">
        <property type="protein sequence ID" value="MYW29523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="13411" checksum="486403C4D3491FA3" modified="2021-04-07" version="1">AHQGAPGLAHGGVLATALDETLGSLNWLLRTIAVTGRLETDFVRPVPVDTVLHLDARITAVHGRKIYSTATGRIGGPEGPVAVRADALFIEVKVDHFIENGRSAEIQAAMADPDQVKRARAFEVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB39</accession>
    <name>A0A7K2ZB39_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="13" type="ORF">GT040_09710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="WWKE01000450">
        <property type="protein sequence ID" value="MYW29544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="188"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW29544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="364" mass="38708" checksum="A32B996EAA5FA4D3" modified="2021-04-07" version="1">MHVVLAGGGTAGHIEPALALADALRRQDPTVGITALGTERGLETRLVPERGYELALIPAVPLPRKPTPELITVPGRLRGTIKAAEQILERTKADCVVGFGGYVALPGYLAAKRAGVPIVVHEANARPGLANKIGSRYAHGVAVSTPDSKLRDARYIGIPLRRTIATLDRARVRPEARASFGLDPNLPTLLVSGGSQGARHLNEVVQRVAPLLQRSGIQILHVVGPKNELPRIDNMPGMPPYIPVPYVDRMDLAYAAADMMLCRAGAMTVAELSAVGLPAAYVPLPIGNGEQRLNAQPVVNAGGGLLVDDAALTPEWVQGNVLPVLSDPHRLYEMSRAAAEFGRRDADDLLVGMVYEAIASRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB79</accession>
    <name>A0A7K2ZB79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000455">
        <property type="protein sequence ID" value="MYW29572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="220" mass="24169" checksum="98867DADE29DC655" modified="2021-04-07" version="1">MVGAEVNGKGPGGRRIRGLDAEERRARRREDLLDAALELFSAQGYQDTSIEQICKQAYVGTKSFYEVFTGKENLYLALLDRIVVDVTGRLTTALDALGDDEDGTEAARRLIRHFADAFVEDVRVARVTFGEGRAVTPLAEVHRRTNRRWAATFVETVWQRLGLPVAPHAHVVAMGLIGGLFDIIADWLLDGDTARPDDRAALQAGLDRFYTVISAGLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBC5</accession>
    <name>A0A7K2ZBC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_09825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000454">
        <property type="protein sequence ID" value="MYW29565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="376" mass="39588" checksum="69EE44401C613830" modified="2021-04-07" version="1">MSPQSLAATVTPSGIRFDGVSVAYGENTVLDRLDLTVEPGEVMALLGPSGSGKTTALRAVAGFVRPASGRVFIGGRDVTRLPPHQRGIGMVVQQYALFPHLKVKDNVAFGLKAHRTPKAEIAGRVTEALELVGMAAYATRHPRELSGGQQQRVAIARALAIRPGVLLLDEPLSALDARLRSGMLAELARLHRELPDVSILYVTHDQVEALTLADRIAVMDRARLQDCGTPEELYRRPRTEFTASFVGNANLLPVTVTGPGRVDLAGAALDAPTDTATPGATATLCVRPHLVGLGPGPNALTGTVTEVQWRGSTHRVHADTAGHRLMADLRELRDPPALGDPVTLHFAAEDAVLLPAGAVPEGPETAPAKAQAVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC05</accession>
    <name>A0A7K2ZC05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000531">
        <property type="protein sequence ID" value="MYW29901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="47" mass="4804" checksum="A19155A8873F2AF7" modified="2021-04-07" version="1">ERADGDRTEGAPADGARDGLVVGYATPAEHAYPEALEALCRALPPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCD4</accession>
    <name>A0A7K2ZCD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XdhC/CoxI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000557">
        <property type="protein sequence ID" value="MYW30014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="8893" checksum="10B8CF9A995622AA" modified="2021-04-07" version="1" fragment="single">MLDIADALHRWTAEGREFAVATVVSVDGSAPRGPGAALAIDSEGTAIGSVSGGCVEGAVYELCAQALQDGRSVRETFGYSDEDAFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCH3</accession>
    <name>A0A7K2ZCH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 2-phosphosulfolactate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_12255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15597"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58738"/>
            <dbReference type="EC" id="3.1.3.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ComB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.71" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000561">
        <property type="protein sequence ID" value="MYW30033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050532">
        <property type="term" value="F:2-phosphosulfolactate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005238">
        <property type="entry name" value="ComB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036702">
        <property type="entry name" value="ComB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37311">
        <property type="entry name" value="PTHR37311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04029">
        <property type="entry name" value="2-ph_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142823">
        <property type="entry name" value="SSF142823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="23976" checksum="D14EF7DC95694186" modified="2021-04-07" version="1">MKARFLGIPELVETPPVAVVVDVMRACTVAAWAFAQGAEKIVLAESLDEALALKARHPDWVALKDGPPAPGFDAVNSPGLLRSLDLDGRTVVQKTTAGTVGALAVKDASLVLCAGFVVAEATARFLRERGGDSVTFVVTGEDGRADEDLACAQYIARRVTEDATDADGFLRRAGASRAARELAEGVRQGVHPDDIDLCLELDRFPFAMVATSEDSLMVLRPHPGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDC1</accession>
    <name>A0A7K2ZDC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4253 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000652">
        <property type="protein sequence ID" value="MYW30308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4253" evidence="2">
        <location>
            <begin position="164"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="273" mass="29364" checksum="6DA3E14D4F77BBA8" modified="2021-04-07" version="1">MATLPNPLPSLASSGLDLPPGSLVDATLDGPWHEPLLWYADGPAAPRDWTALRTAGRRLGLLPVLVNGGSHGQWPEEWDLCPDSTTYPGDHDADEVLAGYWTDYADDEVGEVGEADDGSERSAGSWPGLAPTPQEAGEDPDEAAAGLAGVITADPDSWLGGARMALVPARRSADIPATIGWSGPVNHENDVARLCAVLRSWEDRYDARVVVLGFDTMIVSVGRPPTTPEEARALAAEHYAFCPDNIDQSPPYDLGAYAEKHVLDQEVWSFWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDE3</accession>
    <name>A0A7K2ZDE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000656">
        <property type="protein sequence ID" value="MYW30356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="188" mass="20798" checksum="559C1B4687BA5C26" modified="2021-04-07" version="1">MTSSFEFHTYPARLSDAQRDRVLGVLRDGAAQGKLSHDTFMRRMELALVARRPEELAALTSDLDTGSRFSQGLVKAVGGISAFPGRLRRAWQTERLPKLLLPAPSRYPLLIGRDPGNGLRLNHETVSRLHAELTVQHGRWVLRDLGSTNGTCVNGQRLVGSIPVRDGDQVSFGRMSFRLTTPSMRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDK4</accession>
    <name>A0A7K2ZDK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000667">
        <property type="protein sequence ID" value="MYW30431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="29673" checksum="F762C6326DD7088E" modified="2021-04-07" version="1">MRIGIGIPNQVRDVNAQVIPAWARRAEEAGFATLGTTGRIAYPGVMDTVALAAAAGATTRIGLLSQVLVATTWPGTLLAKEAASIDAVSGGRLTLGIGVGIREDDFVVPGHGPRDRGARMDRDLETYRSVWAGEPVPGSPNPAVPAGGRQVPLLFGGTTPAAYRRMVQWSDGYIAGSVPASLAAGAFDTARTAWQEAGRPGQPRLVGVNYFALGDPDRARATVADYYGATATAGFQDLVVNNVHTGAAAIRDAVRQFEDLGADELILGPGTDDLDDVSRLADIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDQ3</accession>
    <name>A0A7K2ZDQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000684">
        <property type="protein sequence ID" value="MYW30481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="158" mass="17516" checksum="BE71BF4199ED16A9" modified="2021-04-07" version="1">MHHHGYAWLGEKRTFDKESIRRPPGQAPTPTSDPDVHERYREAVAVFPASDVPPIQTAHWLMKPASTIRGTWEEPKEAGGWLGLQLAEFAPRFASEQDREATRLVLLVRAAVERLAWGGDVSLGHYLRGTVHHSVALVTCSPNRNAPDLPCPARQIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDT2</accession>
    <name>A0A7K2ZDT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000708">
        <property type="protein sequence ID" value="MYW30517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="16571" checksum="69A6350041BC87A7" modified="2021-04-07" version="1" fragment="single">AALAKTPEQLAVLGRAGVVDAGGRGLVAVLGALVEAVTGQAPVRGPRTEPGKAAAPVDGGSVVGLPVGGVPVPAGGALVEGPLDCPEDLDGGGPAFEVIYLLEARDEQVDRLRTRLDALGDSLVVVGGDGLWHVHVHVDDAGAAVEAGVEAGRPYRIRITHFATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF84</accession>
    <name>A0A7K2ZF84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_17255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000810">
        <property type="protein sequence ID" value="MYW30978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076966778.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000810.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="10191" checksum="14FC054434886D3A" modified="2021-04-07" version="1">MKGTAVSEHHFTIDDLKRILFEGAGADESAALGGDILDTDFENLGYDSLALLETGGRIEREYGITLDDEVLNDNRTPRALVEAVNDNLRRVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFF1</accession>
    <name>A0A7K2ZFF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000829">
        <property type="protein sequence ID" value="MYW31062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="39" mass="4501" checksum="573EC26C6B3B22E0" modified="2021-04-07" version="1">ITARRYLEHLVTVGSAARRPHYGQVGRPELHYRWLAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFS8</accession>
    <name>A0A7K2ZFS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_18410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000862">
        <property type="protein sequence ID" value="MYW31192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="6"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="20260" checksum="6FA6E97BEB23C781" modified="2021-04-07" version="1">MKVPAKASLRRELLAARALLTKNDVTEAAVVLAAGASALPELADARTVAAYVSVGREPGTRALLDALRERGVRVLLPVLLPDNDLDWAVYRGAEHLLPAGRGLLEPDGPRLGPAAVVEAEAVLLPGLAVDGAGMRLGRGGGSYDRVLARLSAAGADPALIVLLYDNEVVARVPVEPHDHPVDAVVTPAGARRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFV2</accession>
    <name>A0A7K2ZFV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="173" mass="17835" checksum="6D7FE37B7762D47C" modified="2021-04-07" version="1">MTLRTRHLGGWAVLLAAALVCGLGTWSYAQARGDRTLAYAKARDAALAQGKRHLATLNSLDGKDATSVSAGLRAWRDSSTGPLHDQLKRTSAADAKTLTTAGDTASGKVTSAALTALDDRTGTAELIATVDIEVTPRTGGPGTQRKRFTATLARTGDGWKVKALTAMAAGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFX4</accession>
    <name>A0A7K2ZFX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPP34 family phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000867">
        <property type="protein sequence ID" value="MYW31230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="222" mass="23610" checksum="842284813259CC15" modified="2021-04-07" version="1">MPSKLLIVEDLTLLLMDDASGAIPTAGTLYYTQGGAVLVELGLAGHVRVDEGDQGLTGIRVHAVVGRPPEDPLLRDAYKKVSEKVRGVQTLLIEIGTGLREPVFDRLVERGTLRRETKKTLGLFRTTSHTIADSAYKKALLEQVRAVLIDGAEPDARTASLIGLLSASGSLPNLHRTVPWSGKVYHRAKELERASWGAEAVNSAVLRTVAAIAAGSAAAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGF0</accession>
    <name>A0A7K2ZGF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH family NRPS accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000917">
        <property type="protein sequence ID" value="MYW31434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7160" checksum="E220A5A3AA6E1805" modified="2021-04-07" version="1">MSDAPANPFDADGEFLVLTNEAGQHSLWPLFAAVPAGWSTAHGPCARQEALDWISAHWAGPVSASTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGI8</accession>
    <name>A0A7K2ZGI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000925">
        <property type="protein sequence ID" value="MYW31467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029742579" evidence="1">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="84" mass="8526" checksum="77B77DEEA4744C1E" modified="2021-04-07" version="1" fragment="single">MRRTGTTRRGALTATGALALGAVLTGCGDDDKSQGRSGPVRTEAEAVRVEKALRTAAARTAALTLAHYDLAAEAHPALAEGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGN2</accession>
    <name>A0A7K2ZGN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000934">
        <property type="protein sequence ID" value="MYW31502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="20491" checksum="1484A888863EA3F8" modified="2021-04-07" version="1">GGRARVTFDWPAEAGEVAATVEQDGASTVRRVVARSTYVREGLYVDVAPSAFSVTLSAAPRTPDAVVVPPPGGAVRVPEDIAVSYRIVPGARRALRRGPSLLRVTLSCPGEVPDDLPEFVLVARSGNGRDPVRPRTPTDGTTLLRVGGATLSPGSPVELPVPSGLRPPYALRGFLLGEGAADVRLDEPSPTTLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHH3</accession>
    <name>A0A7K2ZHH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001017">
        <property type="protein sequence ID" value="MYW31794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="44" mass="4966" checksum="2F8DA2ABCA20D67F" modified="2021-04-07" version="1">HGGYGFMNEYPVARMWRDSKILEIGEGTSEVQRMLIARELGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHP2</accession>
    <name>A0A7K2ZHP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001033">
        <property type="protein sequence ID" value="MYW31870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="11908" checksum="45512A407CA35D95" modified="2021-04-07" version="1">ASAVSRAWAAASGDPGADAADCAKAVESGDPAAIAVWQDAVDALAAGLVTALTLLDPSTLIIGGGLAEAGETLFTPLRAAVEERVTFQKLPHIVPAALGDTAGCLGAGLLAWDLLSTEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHQ3</accession>
    <name>A0A7K2ZHQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001037">
        <property type="protein sequence ID" value="MYW31886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="88" mass="9299" checksum="3FFE3D89A0F36B4C" modified="2021-04-07" version="1">PAAGSPERAALGAAERRALRAAMARLPGRCSRLLDAMLAPTDPTYREIAGELGMSQGSLGPIRSRCLGCLRRMLAAEVVAPELRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHW8</accession>
    <name>A0A7K2ZHW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511753.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001061.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8847" checksum="76AE9BC0BE175E36" modified="2021-04-07" version="1">MADILAFIIILWILMYLLDANRGNDFVQWVHDAATWLAGWSYDLFTFDAAWARVVAGYGLAAVVYLFIGHAIAGRIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI73</accession>
    <name>A0A7K2ZI73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_22830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001068">
        <property type="protein sequence ID" value="MYW32028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="697" mass="73404" checksum="680295BE07BDC736" modified="2021-04-07" version="1">MTTASEQAPAAQSAAAPPPVLDRRRRNIVFATIVLGMLLAALDQTIVGTALPTIVSDLGGAAHMSWVVTAYLLAETVATVLVGKFGDLFGRKLVFQVSAIVFITGSFLCGLASDMLLLIIWRGMQGIGAGGLMVTSMALIADVIPLRERGKYQGAIGAVFGISTVIGPLLGGLFTDHLTWRWAFYVNVPIAIVVVIAAARNIPSVKAAGRPVIDYSGIALVAVGASALILATSWGGNEYAWGSPMIIGLFVAGIIALTLFCRVETRAKEPMLPMRLFRNPVFTVCSVLSFIVGFAMLGSMIFLPTYLQYVDGDSATLSGVRTLPLVAALLVASIFSGTVVSRTGRYRVFPIVGTLVMAAGLFLLSRMGPESGVWVESLYMVVLGLGIGLAMQVLTIAVQNTVDYADLGTATSGVTFFRTLGSAFGTAVFGTIYANALKPNLTDGVGQAVAAGGDPAVLARASESPQALHALPAAQVEPLAQAYAQTLHTVFLWTVPVALIGFVVALFLKEVKLRDSARLASTDMGDGFAQPGSGDSEKLLEIAVAQILHGAGPDTARRITAGSDTRLDMAGAWAVMQVDLFTRLVGHAGLRLIAARHRIPPEVLVPVFDRMIEEGYLTGDGRIFSHTAAGRREANVISDAWGRWLNERLAEDGARPDDAQLRTAVDMIAKRLLAEDLAQELSPAPHPGGSTRVGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIW5</accession>
    <name>A0A7K2ZIW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="13" type="ORF">GT040_23795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="WWKE01001112">
        <property type="protein sequence ID" value="MYW32209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="10">
        <location>
            <begin position="70"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="9">
        <location>
            <begin position="185"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="12">
        <location>
            <begin position="390"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="11">
        <location>
            <begin position="563"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW32209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="750" mass="83749" checksum="A491D279D4172C9C" modified="2021-04-07" version="1">MSQQPSSEVPVQPAQPSVGALAAHRPHAVAHPSSGNAGFSTAADLDPDLDADADAYEPDRDGDELPQGRFLDRERSWLAFNERVLELAEDPATPILERANFLAIFASNLDEFFMVRVAGLKRRIATGVATRSASGLQPREVLDLIWTRSRELMARHAACFQQDIAPALSDESIQLIRWPDLTEKEQARLFTFFRQRVFPVLTPLAVDPAHPFPYISGLSLNLAVVVRNPVSGHRHFARVKVPPLLTRFLEASPQRYVPIEDVIAAHLEELFPGMEVLAHHMFRVTRNEDLEVEEDDAENLLQALEKELMRRRFGPPVRLEVEESIDPYVLDLLVRELKVSDAEVYPLPGPLDLTGLFAIASLDRPELKFPKFIAGTHRDLAEVESASAPDIFAALRERDVLLHHPYDSFSTSVQAFLEQAAGDPDVLAIKQTLYRTSGDSPIVDALIDAAESGKQVLVLVEIKARFDEQANIKWARKLEEAGCHVVYGLVGLKTHCKLSLVVRQEGDTLRRYSHVGTGNYHPKTARLYEDLGLLTADPQVGADLSDLFNRLSGYSRRETYRRLLVAPKSLRDGLIARINKEVAHHRAGRPAYVRIKVNSMVDEAIIDACYRAAQAGVPVDIWVRGICAIRPGVAGLSENIRVRSILGRFLEHSRVFSFGNGGEPEVWFGSADMMHRNLDRRIEALVRVTDPAHRAALSRLLETGMADTTSSWHLGPDGNWTRHATDAEGQPLRHVQEMLIDARRRRRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIX0</accession>
    <name>A0A7K2ZIX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF3390 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_24265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001134">
        <property type="protein sequence ID" value="MYW32298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="LUD_dom" evidence="8">
        <location>
            <begin position="87"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="328"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3390" evidence="9">
        <location>
            <begin position="416"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW32298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="526" mass="56650" checksum="DB9932FE47B79C8A" modified="2021-04-07" version="1">MSTFLGMPARPPRSPYGTGNLRGDEPFPRAAHQELGNGQLRRNLHKATTTIRAKRLNVTGELPDWEALRDAGSAIKTDAMNRLPELLEQLERKVTEHGGTVHWARDAAEANGIVARLVRATGSSEVIKVKSMATQEIGLNEHLESAGITPYETDLAELIVQLAHDKPSHILVPAIHRNRDEIRQIFLDRIPGVDPELDNVPAHLAAAARAYLRQKFMTTKVAVSGANFGIAETGTLSVVESEGNGRMCLTLPDTLITVMGIEKVLPRYQDLEVFLQLLPRSSTGERMNPYTSLWTGVTHGDGPQDFHLVLLDNGRTAALADAIGRAALNCIRCSACLNVCPVYERTGGHAYGSTYPGPIGAVLTPQLAGMHAADDDPNSSLPYASSLCGACFDACPVKIDIPSLLVELRHQHTEQTGTTPEKLAMKAAAAVMKRPALYTGAQKAAGLGRAVAGRDGTISRLPPPFNGWSDSRDTAAPPRQTFRAWFASDEGRATLRAAADEHDRNQAGSDRGPAGSDRNQGEDGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ73</accession>
    <name>A0A7K2ZJ73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001161">
        <property type="protein sequence ID" value="MYW32410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19016" checksum="A4B67557C87091F9" modified="2021-04-07" version="1">MPPQDMTTAASPSGGAAPEHPGPDRLLDSLQHQVAVFARRAEQTRLGGVGQVRNSMDRAAYLLLNRLDKEGPMGVKALAAGMGIDSSTVTRQVAPLVDTGLVKRTSHPEDGRAVVLQLSPRGEARLEEVRASRRELMSQVTDGWTQEERDTFCALLTRFNGSLAARQAAYQPPQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJA2</accession>
    <name>A0A7K2ZJA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001172">
        <property type="protein sequence ID" value="MYW32440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="245" mass="26289" checksum="206C749FCE3A54CB" modified="2021-04-07" version="1">ASLVVTALAGPLVHLLSGTALPVRGPVAAVVARRVAGRLEEKGRLTARAEEPWTSRAAVEARRKLHRRPVQDALTAPTRIGDSFAAMGERILGRHRLDAQLCWPLLQQLFDEPARRDLEHASDQVLGRARNLVWAVLTVVTALPLALLDRVALWPAALAALAGAAVGALLLAGLGDGVDDYADTVEAALLRHRDPLYAAAAWPLPANTADEKRTGEAFTAYLRRTGHPAPQITFERPPPEEPSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJB6</accession>
    <name>A0A7K2ZJB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentachlorophenol monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001166">
        <property type="protein sequence ID" value="MYW32431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="538" mass="57525" checksum="F211A1AE6ECFBA07" modified="2021-04-07" version="1">VLIAGAGPVGLTLAAELRRSGVSCRIVDRLPARLPYAKAVGIQPRTLELFDRMGLVRDVLDAAVPMRGQLTYVNGAKQGRIELVLPPEVPYGFAALPQYETERVLEEFLGRFGTRIERSTELVAFAQDPVGVTSRLRSSDGGEEELRSRFLVGCDGAHSVVRKGLGLTFEGGAFPEEYMLADVEVGWGLPPGYGVRSMHRGEDGAVDDLLVCIPLPGRGRYRMSMLVPPELSASRPSEPSAGDGVAHGLEGGTAPALADIQKVLDRLAPEPVTASALRWSSVFRISHRLVDRYGEGRVFVAGDAAHIHPPTGAQGMNTGVQDACNLAWKLALAVEGAADPGLLPSYDAERHPVGEEVVGRTVRHAAEGVQADPEAPETLLLREAQLLVNYRESPLVTPLPPGDEAALRPGDRAPDCGGLTGDIAAYPVRLFDLLRGRGHVLLVYGHHPAGDTPSDLAAAARELTGGRMETCRILPADAPPDEATGFPHHHDSRGEFARQYRVEEGAAFVVRPDGYLGACLQPPTAGRLKEALGREFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJF7</accession>
    <name>A0A7K2ZJF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="2">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001186">
        <property type="protein sequence ID" value="MYW32478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14317" checksum="796B81F580DADE06" modified="2021-04-07" version="1" fragment="single">LDRMLDATAARALDAVTFTSAPAAASFLGRAEARGLLPEILGALRDDVLAACVGPVTALPLQARGIPTVQPERFRLGPLVQLVCAQLPTTARVLPIAGHRVEIRGHAVLVDDGLRAVPPAGMALLHTLARRPGWVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJY4</accession>
    <name>A0A7K2ZJY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001214">
        <property type="protein sequence ID" value="MYW32654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="76" mass="8185" checksum="82A5568892844926" modified="2021-04-07" version="1">DAEVLLLPDAALRTAASIPELEEALGKPVLTANQVTVWEGLRLTDRRVWAPTLGTLFATRPPAPGTVEPKGIEVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK66</accession>
    <name>A0A7K2ZK66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">rpsE</name>
        <name evidence="12" type="ORF">GT040_26580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966944.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001248.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZK66"/>
    <dbReference type="GeneID" id="6211238"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW32740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="201" mass="20336" checksum="B5718F61BE454C9A" modified="2021-04-07" version="1">MAGPQRRGSGAGGGERRDRKGRDGGASAAEKTAYVERVVAINRVAKVVKGGRRFSFTALVVVGDGDGTVGVGYGKAKEVPAAIAKGVEEAKKNFFKVPRIQGTIPHPITGEKAAGVVLLKPASPGTGVIAGGPVRAVLECAGVHDILSKSLGSSNAINIVHATVAALQGLQRPEEIAARRGLPLEDVAPAALLRARAGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKR4</accession>
    <name>A0A7K2ZKR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001291">
        <property type="protein sequence ID" value="MYW32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="12076" checksum="4DA6DC0AF4FAD29E" modified="2021-04-07" version="1">LGRLVRGQRLAVLDPARRAEYPVAPGYAPGEHHFPHDYARTPGSLARRWFTDEELERSLDHLAAEQQEDGGWPVNWRQWAPGTALEGRPLVTLRALETLRAYGRPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKR6</accession>
    <name>A0A7K2ZKR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001297">
        <property type="protein sequence ID" value="MYW32941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018516017.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001297.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9732" checksum="C05C8C1508268EBB" modified="2021-04-07" version="1">MATIPDPHLAMVRPVTPRTPQGCEECLKEHSPWVHLRLCLTCGHVGCCDSSPLKHARRHAGSAGHPIVQSFQPGEDWRWCYVHEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKV6</accession>
    <name>A0A7K2ZKV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_27295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001269">
        <property type="protein sequence ID" value="MYW32879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511565.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001269.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="31249" checksum="30415B36C4B3560F" modified="2021-04-07" version="1">MFLEFLNPPFMQRALIAAVLVGITAPAIGIYLVQRRQALMGDGIGHIAMTGVGLGFLLSTSPVWMATAVAVAGAVVMELIRWYGHTRGDLALAMLFYGGMAGGVMLINLSDTGSNANLTSYLFGSLSTVSESDVIAICVLAAFVVLVTVGLRRQLFAVSQDEEFARVTGLPVRVLNLLVAVTAAVTVTVAMRVVGLLLVSALMVVPVAAAQQITKSFKVTFVLSVVIGTGVTLAGTVTSYYQDVPPGATIVLLAIAVFVALTALAAPLARRRARASEVKGAECTLEVPAARRGTDDLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL17</accession>
    <name>A0A7K2ZL17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3117 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001306">
        <property type="protein sequence ID" value="MYW33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966491.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001306.1"/>
    </dbReference>
    <dbReference type="GeneID" id="61439316"/>
    <dbReference type="GeneID" id="63982596"/>
    <dbReference type="GeneID" id="66960892"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021465">
        <property type="entry name" value="DUF3117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11314">
        <property type="entry name" value="DUF3117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="55" mass="5702" checksum="9A970F625EE97662" modified="2021-04-07" version="1">MAAMKPRTGDGPLEVTKEGRGIVMRVPLEGGGRLVVELTPDEADALGDALKKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL68</accession>
    <name>A0A7K2ZL68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="65"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="431" mass="46668" checksum="0E4582F0807ECD5E" modified="2021-04-07" version="1">MKLHEVLTAAASEGAEAPSRLSADLRRVVAVDNALSGIDVWGGDYGSLVAAYESGGPDPSVTGVVLSLDEEESIGRCIGSAARDCTGIVLLDSGSTDSTLEIARSSSAAVKISSRPWPGSFSEQRNHAITLVDDGWLFFIDADEYILPEDQGKLRPVLRVLDFLLPGQDFLVSPRLANCERGDVATNTRKIFRRGSPFRFMGDIHERPYFPDGSSPSWIELDFGMEHTGYLPEVVTAKKKAGRSKEMIKACRSAEPQNPKWVYYEARDVLLPAVRSPQDARAAYDHLHSSLPWYGRSGIPDCEADQLLDATILLCDLALRFGGREEIANHASALTDLGRPVEAAYYAAVVEFGSAMTVLNRIPSRLEPVLDVATPDTAMTLGKIRELQALVAFSSGDYAGGVAYYHQAEALGCGESVRDSMDRARAALAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL73</accession>
    <name>A0A7K2ZL73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001313">
        <property type="protein sequence ID" value="MYW33091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="7248" checksum="C162AF34D9B86657" modified="2021-04-07" version="1">MKIDWAALASVFGVSLVVTVALVGVFTLGIVALSKLSAPAGGATGGSAALARTGAYAAFTACVAAVAYGIYLIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL74</accession>
    <name>A0A7K2ZL74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_28415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001313">
        <property type="protein sequence ID" value="MYW33090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="422" mass="42747" checksum="8AB936736DFE3E99" modified="2021-04-07" version="1">MEHITLLLAIVVVTALVFDFTNGFHDTANAMATTISTGALKPKTAVAMSAVLNLIGAFLSVEVAKTISGGIVNEDGIRTEVIFAALVGAILWNLLTWLVGLPSSSSHALFGGLIGAAVMSAGWSSINGGTVVTKVLLPAIAAPLVAGLAAMLATRLTYRINRNVTDPNQQKSTAKGYRAGQIASAGLVSLAHGTNDAQKTMGIITLALVTGGVLAPGSNPPMWVIVSAGIAIALGTYLGGWRIIRTMGKGLTDLQPPQGFAAQTSAATVILASSHLGFSLSTTQSCSGAVMGAGLGRKGGVVRWSTATRMFVAWGLTLPAAGLVGAGAEFLTKQGPWGIAVTAVILVGGSFAIWVASRRQPVDHTNVNDTEDATVDEPQGVVTTAMAAVAPPPTAGAVAELSTTIPAPAQAPDDTARPAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL84</accession>
    <name>A0A7K2ZL84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_28490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001317">
        <property type="protein sequence ID" value="MYW33103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="306" mass="32763" checksum="F15666CDB838A59A" modified="2021-04-07" version="1">MTMTSPTPTAPVKLAPPPKGSAPHGPRRFRMGAGQQMKGGPFAYIALAVVGFGSLLPLYWTLVAASRTQDEVLASTPPFLPGAKLLENVQTAWEQANLGKAIVNSIIVSSSITAATLFFCTLAGYAFAKMRFRGRGWLMTAVIATLTIPPQLSVVPLFMMMSGLGWGGQLESVIFPTLVSAFGVFFMRQYLIEALPYELIEAAKIDGANNFRIVVSVVLPVARPAMMVLGMLTFVQAWNDFFWPYLALNQQNPTLQVALGQLSASYTPDQSIVMAGALISTLPLLAVFVLFGKKIVGGIMSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLE3</accession>
    <name>A0A7K2ZLE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001333">
        <property type="protein sequence ID" value="MYW33138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="23584" checksum="B282B0116AF23EEC" modified="2021-04-07" version="1">MAQQERAVRTRQALIRSAAAVFDSHGYAEATLGLISAGAGVSPGALHFHFANKAVIGAAVERAAAGTLRDIAGQAASGRGSALQALIDASHLLARTLASDVVMRAGLQLCREARYEPSGDLRDAWPRHVRRRLAVAADEGTLLPGLGLHRAAALIVAATTGFQVLGKDDPEWISGRSLTDFWEMALPCLATAATVRRLEPGGTFRVGEEGPGCRGRDAVLCAGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLF2</accession>
    <name>A0A7K2ZLF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4135 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001343">
        <property type="protein sequence ID" value="MYW33148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025410">
        <property type="entry name" value="Lant_dehyd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13575">
        <property type="entry name" value="DUF4135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4135" evidence="2">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="7385" checksum="0377CEB1EDAE01EF" modified="2021-04-07" version="1" fragment="single">LLTAYPVLARILARTSLAAADAFTEMLGRLADDRELLASSGVLGDRGHGASPGTLAAGRGPGALTGVEAGAGDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLL2</accession>
    <name>A0A7K2ZLL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001352">
        <property type="protein sequence ID" value="MYW33208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="112"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="284" mass="29412" checksum="6999C5316BBB5CE7" modified="2021-04-07" version="1">TTGRPLTGRRVLILGGTHPAAAAARTRVVELGGSAAINLSRTVTDAVLLPGGEADRRLRRMPELGLPVHDEHWLSAPGAGPGAAPGAASPAIAPSSPEREADRPPSPLVLPRGGVVDLPAPQRDPAPLWHITAAWEPQEAADIDVVAFVLDEDEQVAFDEDFVFYGAPENPAGTVRLLTDGPAEQAIAVDLASLPPASRRVAVAAAMDGEATFGDIGAVQVTAGPGTGAAPLARATLDAATTERTLLLAEFYRRGPVWRFRAVGQGYDEGLANLARGYGVDIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLM2</accession>
    <name>A0A7K2ZLM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_29110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001354">
        <property type="protein sequence ID" value="MYW33218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511919.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001354.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="28482" checksum="6C1B490BE12B13A7" modified="2021-04-07" version="1">MKRMGMLFRAKANKALDRAEDPRETLDYSYQKQLELLQKVRRGVADVATSRKRLELQLNQLQGQSSKLEDQGRKALALGREDLAREALSRRAALQQQVTDLETQHTTLQGEEEKLTLAAQRLQAKVDAFRTKKETIKATYTAAQAQTRIGEAFSGISEEMGDVGLAIQRAEDKTQQLQARAGAIDELLASGALDDPTGTAKDDIAAELDRISGGSDVELELQRMKAELAGGSSSSQQAIEGGAQDGTQQSQQSPHKFDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLR9</accession>
    <name>A0A7K2ZLR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_29405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001361">
        <property type="protein sequence ID" value="MYW33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011408">
        <property type="entry name" value="Aldehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699:SF211">
        <property type="entry name" value="PTHR11699:SF211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="34"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="478" mass="51050" checksum="40F967E64ACB5063" modified="2021-04-07" version="1">MASAFEYAPAPESRSVVDIAPSYGLFIDGEFAEAADGKVFKTVSPSTEEVLSEVARAGAADVDRAVKAARKAFEKWSALPGSERAKYLFRIARIIQERSRELAVLETLDNGKPIKETRDADLPLVAAHFFYYAGWADKLDHAGYGANPRPLGVAGQVIPWNFPLLMLAWKIAPALATGNTVVLKPAETTPLSALFFADICRQAGLPKGVVNILTGYGDAGEALVTHPDVNKVAFTGSTAVGKAIARSVAGTDKKVTLELGGKGANIVFDDAPIDQAVEGIVTGIFFNQGQVCCAGSRLLVQESVQDEVLDALKRRLSTLRLGDPLDKNTDIGAINSAEQLARITALVETGEAEGAERWSAPCELPSSGYWFPPTLFTDVTQAHTVARDEIFGPVLSVLSFRTPDEAVAKANNSQYGLSAGIWTEKGSRILAVAGRLRAGVVWANTFNKFDPTSPFGGYKESGYGREGGRHGLEAYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLT2</accession>
    <name>A0A7K2ZLT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001354">
        <property type="protein sequence ID" value="MYW33219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511920.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001354.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="10037" checksum="34FEDA6E5D2CB2EB" modified="2021-04-07" version="1">MIVRIMGEGQVKLADSHFVELNELDDVLLKEMDSGDGPGFRTTLHALLDKVRELGTPLPDDSLEPSELILPAPDATLEEVRAMLSDDGLIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZME8</accession>
    <name>A0A7K2ZME8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001416">
        <property type="protein sequence ID" value="MYW33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="58" mass="6017" checksum="DC8D8806540227F8" modified="2021-04-07" version="1" fragment="single">MRYCILGTTRALRDDGTAVALGGARLRALLTVLALQPGRTVPAGVLVGEVWDGDPPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMG7</accession>
    <name>A0A7K2ZMG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L,D-transpeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_30900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001434">
        <property type="protein sequence ID" value="MYW33555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029894107" evidence="4">
        <location>
            <begin position="31"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="75"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="259"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="422" mass="44367" checksum="DAFA3ABA7E52692B" modified="2021-04-07" version="1">MEKRVMTDSKRRRGLAAVSALLGGVLVLSACTDDGGEKKAGAGSSESSQAQEVDKAAAEDASEAQIAIKPENGATNASINNAAQVSVKKGKLTEVVMTTADGTAVEGTLAADGSSWKPAGQLERSTTYKIDATAEDAKGRKAHENSSFTTVSPDNSFIGNFTPEDGSTVGVGMPVSINFNKPITDKKAVQDGITVSSSSGQEVVGHWFNGQRLDFRPEDYWQGGSTVTLKLALDGVEGADGVFGVQQKTVTFKVGRNQVSTVDAKTKMMTVTRDGKTIKTIPISAGAPENPTYNGEMVISEKHKETRMNGATVGFTDDDGKGEYDIKDVPHAMRLSTSGTFIHGNYWGKGIFGTANTSHGCVGLADVKGANDPSAPGAWFYDNSMVGDVVIVKNSPDKTIKPDNGLNGWNMDWAQWKAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMY3</accession>
    <name>A0A7K2ZMY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoadipate--succinyl-CoA transferase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001446">
        <property type="protein sequence ID" value="MYW33715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="27637" checksum="B78EE595B6E04771" modified="2021-04-07" version="1">MNEERTRVAGAVTSAELLSVVAARELAGRRTVFAGIGLPTLAAELAHLTVAPEIEVVYESGVCGAHPSRLPETIADAVLITGAEAVLPMAALFGSVLQGGHIDVGFLGAAQIDRWGNLNTSVIGEWERPSVRLPGSGGAVEVMANAREVFVVMRRHTPRSFAEELDFCTTPGPDRALADGIRPLGTGVTRVITELGILARDGVGDELRLVAVHPGVTVEQVRAATGWELKVADTVTTVEPPTGAELRLLRDDVDPDRVYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMY6</accession>
    <name>A0A7K2ZMY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001444">
        <property type="protein sequence ID" value="MYW33707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510125.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001444.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7802" checksum="A22684515C578B91" modified="2021-04-07" version="1">MTVDPSDPDTFESTEPDTPGPEAPEADAAEQRTDVRPEGDEQVEDADLATANEADVAEQRRVIPLDEDDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN46</accession>
    <name>A0A7K2ZN46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2064 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001465">
        <property type="protein sequence ID" value="MYW33783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="11107" checksum="3187243E21F84BB3" modified="2021-04-07" version="1">ITPALLAPALAPDTWEGCDAWFGPAEDGGFWALGLARPDPALLRGVPMSVPETGAVQRRRLVEAGLAVRDLPVLLDVDTASDAHRVAADAPGGRFAAALGRLTGAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN88</accession>
    <name>A0A7K2ZN88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_32275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001484">
        <property type="protein sequence ID" value="MYW33821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="8"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="506" mass="52251" checksum="8A0CBDA5606FD961" modified="2021-04-07" version="1">MSAAPVWSVDPRSGNPREQVAVEATAEEVDRVVRAAHSVRDALADRTARAAFLRAAAELLEKSGPHIIEAADAETALGPARLTGELARTAAQLRAFAEVVDEGAYLDIRIDHEDGSRTPPWPDLRRWKIPLGVVAVYAASNFPLAFSVPGGDTASALAAGCPVVVKAHPGHPATSELCVSVLRRAAARTGLPEDVVTLVHGFDAGIELVRHPLVSAAGFTGSVRGGRALFDAAAARPAPIPFHGELGSLNPVVVTEAAAAERAPEIGGGLGASMTLGVGQFCTKPGLVLAPTGDTGDRLVRALTETVSSAGSGVMLDHRMRDAFLAGVRERAALPDVETPVTPGAGGQHTVSAGFLTVPAAALTAEGPHDALLEECFGPVTVIARYGSEDEVAAVLARLPGNLTATLQTATEGDDPEAAGLLAALTSLAGRILVNGWPTGVAVAPAQHHGGPYPATTSPSTSVGATAIERWLRPVTYQNTPDPLLPPELRETNPLDLPRRVDGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN90</accession>
    <name>A0A7K2ZN90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001482">
        <property type="protein sequence ID" value="MYW33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029809570" evidence="1">
        <location>
            <begin position="34"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="450" mass="48903" checksum="6B2A2614E536C2ED" modified="2021-04-07" version="1">MRSSVLRRTCTAAVATALAVTGLAACNSEGENAADGKTRITVNCWPQPSAKIDHQRFDEDVKTFEKQNPDIDITAHDAFPCQDPKTFDAKLAGGQMEDVFYTYFTDTERVVSINQAADITEYVKDLKAYKDIAQPLRDAYTVDGKIYGVPRTNYSMGLLYSKALFTKAGLDPEKPPATWPEVQAAAKKIAGLGNGTVGFAEYSAQNQGGWHFTAHIYSQGGSVVSEDGKKATVDTPEGKAVLQNLKDMRWRDNSMGAKQLLIINDTLQMMGSGKLGMYLAAPDNVPRIVKEAGGKYEDLAFAPMPGGKGTLMGGDGYMFNKKATPEQIKAGLKWLEWTFLTPGQGYMNDYARAAEDKSPVGLPEPRLFTGATDAKDQELKKASANVPVENYQAFIDGGQQLDMKLEPKHGQQIYAVLDGAVSAVLTKKDADIDQLLKDAQSKIDGILTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNA5</accession>
    <name>A0A7K2ZNA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="34"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22556" checksum="2586E47B5B52EFD3" modified="2021-04-07" version="1">MTSSVPWQERLSAGTEAVQDEVIRWYQETPEGQAYVPTMIWGTLQTEAYATVILGQVVDFLGVPDDVPAGVAKRMQRQQVLHDGEHHYDVVLGEQALYTNIGGPDVMREQMDRILRDIDLPSLTLGVIPATAPVDMLPVHAFNLHGDEVHVELVSSGLNVTEPSELDLYRKAFSQLRDAALYGEGAKELLQKAWSFWSGARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNB3</accession>
    <name>A0A7K2ZNB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nuoI</name>
        <name evidence="8" type="ORF">GT040_32430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001486">
        <property type="protein sequence ID" value="MYW33851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="224" mass="24166" checksum="4E8E71F57919A641" modified="2021-04-07" version="1">MSEKPELTGSSGSAGSSGESGAAAEKFQNPVAGFGVTFKAMFKKRLTEQYPETPKVTAPRFHGRHQLNRHPDGLEKCVGCELCAWACPADAIYVEGADNTEEERYSPGERYGRVYQINYARCILCGLCIEACPTRALTMTNEFELANTTRESLIYTKDELLAGLEEGMVDSPHAIFPGMDEQDYYRGLVTEAAPGTVPQPALSKGEEPKSDESAGAQQGRGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNI0</accession>
    <name>A0A7K2ZNI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_32720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="29018" checksum="A5CB04D019CA2FD7" modified="2021-04-07" version="1">MSDVLELVDVSVVRDGRALVDDVSWSVKEGERWVILGPNGAGKTTLLNLASSYLYPSKGTATILGEQLGGVGTDVFELRPRIGMAGVAMADKLPKKQTVLQTVLTAAYGMTATWHENYEAVDEERARAFLDRLGMTEYLDRKFGTLSEGERKRTLIARAMMTDPELLLLDEPAAGLDLGGREDLVRRLGRLARDPYAPSMIMVTHHVEEIAPGFTHVLMIRQGKILAAGPMETELSSRNLSLCFGLPLIVEHTGDRYTAHGLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNL1</accession>
    <name>A0A7K2ZNL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001498">
        <property type="protein sequence ID" value="MYW33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7462" checksum="6A02FDEF22601A87" modified="2021-04-07" version="1" fragment="single">MTRTPSAVARALERIARLDPALNAFTEVWPEEGLAREPAALHLPLRGLPFAVKGPSGIRSYAARRLIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNU4</accession>
    <name>A0A7K2ZNU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001538">
        <property type="protein sequence ID" value="MYW34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="19948" checksum="1F0FA6DBA955FAC5" modified="2021-04-07" version="1">MLWLGTETCALGPYRADLVETYWRWEQDPALLVGYGRQQPESLEARTEGMVHQLRGDNIRFTVYDLTTGSPVPAGVATLLPDPSVRTAEYVVMLAPEARGRGLGTAATRLVLDYAFHITNLRMVWLKVLAPNKAGLRAYEKAGFRTAGTLREAGYWLGTVCDEILMDTLAGDFTGPSVIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNX1</accession>
    <name>A0A7K2ZNX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001507">
        <property type="protein sequence ID" value="MYW33978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18613" checksum="DB647C8FD4ED74EC" modified="2021-04-07" version="1" fragment="single">MVAGVSVVGASGAWFLAEPLALRGLVVAVAAAALTGAYLMRSWDRAAGLQVAELTRARTRDEWRAEERIAELEQDLEESRELRTRLETKLRRKRVELAGLRGEHAGLLRRYANAETERASALEGRRQLAIEAAATPAELPAGRSTPTPEAYRRADEALLNLTRNAALQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNY0</accession>
    <name>A0A7K2ZNY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001539">
        <property type="protein sequence ID" value="MYW34052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18443" checksum="08FAFF8C5206502D" modified="2021-04-07" version="1">MSEPLTTAGEGFHPHLHETPGDRPTTPLHTRLHHIRADALDGDTAQTGGMRRFAAISGKTTGSEKLWMGQTHVAPATSSSDHHHGASETAIHVVSGHPEFVFLDDSGEEPQEVRLRTSPGDYIFVPPFVPHREENPDPSEEAVVVIARSTQEAIVVNLPRLYALPAEDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNY2</accession>
    <name>A0A7K2ZNY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MTS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_33415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001538">
        <property type="protein sequence ID" value="MYW34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022446">
        <property type="entry name" value="CHP03704_MeTrfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03704">
        <property type="entry name" value="PrmC_rel_meth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="4">
        <location>
            <begin position="81"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="270" mass="28285" checksum="D4C20976AC3817C5" modified="2021-04-07" version="1">MSVHPLSSFSVTVAALRRAGCVFAEDEASLLHEAAASPDHLASLVEGRVAGLPLEHVLGWAEFRGRRLAVDAGVFVPRRRTEFLVAQAAALAPERAVVVDLCCGSGALGVALATEAAASLGRVDLHACDVEPAAVRCARRNIGGLGQVYEGDLFEPLPVGLRGRVDVLLANVPYVPTADVELLPAEARVHEPRVALDGGGDGLDVMRRVAAEAPGWLAPGGSLLVEASERQRDAAVHILRCAGLVPRVVVCEELYATVVIGTRSAGHVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPB9</accession>
    <name>A0A7K2ZPB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001554">
        <property type="protein sequence ID" value="MYW34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="12343" checksum="1EE5269B78BA58C0" modified="2021-04-07" version="1">MARSLDGLVLSPVADQAPGQVGTRTRFTYHEQDGAIWAGYAGGDVVRGHLVGTREGDFLDFRYVQLKQDGTTSSGHCLSTVTDLTDGRVRLDERWEWESQEGSGTSVVEEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPL2</accession>
    <name>A0A7K2ZPL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">GT040_34675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001588">
        <property type="protein sequence ID" value="MYW34283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="192"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="33628" checksum="6FCA47B75FCD8D67" modified="2021-04-07" version="1">YGAGEPLPELLAGPDAAATLAASDCHTVLNGITGSIGLAPTLAALKAGRTLALANKESLIVGGPLVKALAAPGQIIPVDSEHAALFQALAAGKRADVRKLVVTASGGPFRGRTREELADVTREQALTHPTWAMGPVITINSATLVNKGLEVIEAHLLYDIPFDRIEVVVHPQSYVHSMVEFTDGSTLAQATPPDMGGPIAIGLGWPERVPDAAPAFDWSKASTWEFFPLDTEAFPSVGLARHVGTLGSTAPAVFNAANEECVDAFLAGQLPFNGIMDTVTAVVSEHGTPAPGTPLSVADVLEAETWARARARELSAKATAEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ59</accession>
    <name>A0A7K2ZQ59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001611">
        <property type="protein sequence ID" value="MYW34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="49" mass="5052" checksum="0FC3C508E31BFCCF" modified="2021-04-07" version="1">AALVDASRSAGLLVVGRRSRRSPVGPHLGHVAHAVIHHSPAPVAVVPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ80</accession>
    <name>A0A7K2ZQ80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001627">
        <property type="protein sequence ID" value="MYW34477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13495" checksum="FBB855E76EB98DA6" modified="2021-04-07" version="1">MPYATVPDLAAWLAPEPAPPNAVRLLTLASQRVDRALLGAYYDLADAEVVEVLRQATVQQVHWMLERGDETEAQSDLQSMSTGSRSFTRRTVGQGAGQTPQLAPSVVDLLRTCGLFRFDPLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQM2</accession>
    <name>A0A7K2ZQM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_36710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001677">
        <property type="protein sequence ID" value="MYW34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="736"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1036" mass="108892" checksum="E4989E92FA164E63" modified="2021-04-07" version="1">MPFLLAPGPRRKTPGPHRKRSAPASTPPPAPPARRSGGESGPSPHRSAFRPDIEGLRAVAVLAVLAFHAAIPGLAGGFVGVDVFFVISGYLITGLLVREAISTGRIRLGDFFSRRARRLLPSAAVVLAAVAVAGAWLTVPLRRTDLEYDVLAAALSVANWRFVSQRTDYLAAGHDQSPLLHFWSLAVEEQFYLFWAPLLAVVVLFAARAVRRGRAVRSVVALVTGALVVGSFALSLHWTEHSVSLAYLGTPSRVWQFGVGALLALLPWHLLRGPRPLRLLCGWGGAAAIGWCVVAYDASTPYPGYAALVPTLATAAVILAAIPGRGERNVQGTYGVGRLLAGRAPRAVGRLSYNLYLWHWPVLVLAEARLGTLGWPARTALTLAAVLPALATMRWVEQPLRRSRTVSELPRRGMAVGVSAIVLPVALALVVGTATLHLMGPATPVDVKGLPPGAASGPSLLARAAGASGASGAPSGDGPVVPNPVQARKDFPPDRNCQVAPEVTRSPECLFGAVDSPDRIVLLGDSHAGQWFSPMLAIASQRGWALQELVKQGCPLPELAVDSPQLGRAYRECDTWRADALERLRTGPKPRLIVIASLNRYTTDPELLSAAWEKTLKPLRAIGAPVVYVEDTPVPGKDIPACVSGAPGYAAGCAFQRAEAVPADPLARRIAAGAVPGVRAIGVNQVLCPGDGPTCPAVRDRILLYRDDAHLTDVAAVVLTPRLERLLTDSGALPAATAPGAPVGDGWTELLRDDFDGPAGSRPSPANWQYDLGTCYPGCPAPQWGTGEIETMTDSTDNVRLDGRGALEIVPTRKGDAWSSGRIETVRSDFAPPPGGVLRIEASIALPDVTGPKAAGYWPAFWTLGAELRDGYTGWPGVGELDVMESVNGRDTVLGSMHCGVLEGGPCKEPVGLTSGPRACATCRTEFHAYAVEVDLGVGEVRWYLDGRVYHRVSAGQMDAGTWKRAVDHGVFLILNVAIGGKLPAADGATAGPGTEPGHPMRVDQVTVKVKRGGKGGTVRSGATRGGSSGPVSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQS8</accession>
    <name>A0A7K2ZQS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_36970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="164"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="426" mass="45125" checksum="D70E25440407D999" modified="2021-04-07" version="1">MDVNAAVAAAAAIAGLLTGVIAMLAFRWSERDLKRPTRTSLRPDSNAALPPGVDTVLSVLSSSAVVLDESDSVVKASSAAYALGLVRGGRLAVEPMLNMARDTRRDGEIRQGELDLPRRGTGRGDTLAVSARVAPLGSRLVLLLVEDLTEARRIEAVRRDFVANVSHELKTPTGALSLLSEAVMDASDDPEAVERFAGRMQIEATRLTNLVQELIDLSRVQNDDPLEDAEPVKVEVLVAEAIDRCRQQAGSKQITMASGGAEGLTVWGNRGQLVGALGNLVENAVNYSPARTRVGIAARRTTGPGGDLIEIAVTDQGIGISEKDRERVFERFYRVDPARSRATGGTGLGLAIVKHVAASHGGEVTVWSSEGQGSTFTLRLPESGAVRERTTGGPLIVNGVNGVGDKDQPPFETDSYDPFPAPEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR67</accession>
    <name>A0A7K2ZR67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">prcB</name>
        <name evidence="5" type="ORF">GT040_37060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001682">
        <property type="protein sequence ID" value="MYW34739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5029988587" description="Removed in mature form; by autocatalysis" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029988588" description="Proteasome subunit beta" evidence="3">
        <location>
            <begin position="54"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3 4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="30165" checksum="78292565C6393F3C" modified="2021-04-07" version="1">MEANTRSTGRLPAAFLTPGSSSFMDFLSDQSPEMLPGNRSLPPLQGAIEAPHGTTIVAASFPGGVVLAGDRRATMGNMIAQRDIEKVFPADEYSAVGIAGTAGLAVEMVKLFQLELEHFEKVEGAQLSLEGKANRLSTMIRSNLAMAMQGLAVVPLFAGYDVDREKGRIFSYDVTGGRSEENGYAATGSGSIFARGSMKKLYREDLTEEQTLTLVVQALYDAADDDSATGGPDVARRIYPIVTVITDEGFRRLGDQESADIARSILERRLEQPDGPRAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS21</accession>
    <name>A0A7K2ZS21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001779">
        <property type="protein sequence ID" value="MYW35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="315" mass="34229" checksum="2E9F46FDFD5A11AE" modified="2021-04-07" version="1">MELEVRHLRALCAIADAGSLHQAARRLGVSQPSLTTQLRRIENSLGAELFRRERTGCRPTPLGRAVLSRARPLVDGMSALVTDALAEADASRGPRLRVGSTASRVVGSWLRRLREALPGTEISLRVDVSAHALLRSVEAGRLDVAFVHEVEGSPLTLPDGLVQRVLLDREPQFISLSRDHPAARRRVVELGDLAGDRWMVDPTVDGEWDGVRRVLGAAGIDPPVLHGDYLTAASLVVLGEAVAPCQPTSGPRDDMAIRPLRGDPLAVRLLLASRPETDTSVVYGELEAAYVEAARRSSGYYAWLLRHRSPLARTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS33</accession>
    <name>A0A7K2ZS33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001781">
        <property type="protein sequence ID" value="MYW35155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046210">
        <property type="entry name" value="DUF6243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19756">
        <property type="entry name" value="DUF6243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="73" mass="7833" checksum="113A4B398548C10D" modified="2021-04-07" version="1">MAKSRNNLLGVGGQRKKLSRAEQQGAGSARGADRKVAEDKKQELVRKMRERAEAQAATTGAEPGEQDARPAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS39</accession>
    <name>A0A7K2ZS39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001782">
        <property type="protein sequence ID" value="MYW35163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="24677" checksum="9B5040EE84814763" modified="2021-04-07" version="1">LHLAWPAGSPVRDIFAACVRGAGITGPAFTGNDVNLTALAEHRHGAGRGAQHLLCVATGHRGVGGALVLDGRLHSGSSGLALEVGHLTVNPEGRPCHCGGRGCLDVETDPLAFLTTARRDPGPEESLLKQAGDLLRTEYEDADVRNAAEALIDRLGLGLAGLVNILNPDRIILGGLHRDLLEADPERLRAVVADRSLWGRSGSVPILPCTLTHNSLVGAAELAWQPVLDDPLAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSP6</accession>
    <name>A0A7K2ZSP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001834">
        <property type="protein sequence ID" value="MYW35318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045925">
        <property type="entry name" value="DUF6344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19871">
        <property type="entry name" value="DUF6344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029546513" evidence="2">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="12537" checksum="067564A0CFE7E854" modified="2021-04-07" version="1">MSTFQPKSIWTAFITAFFALLASLGLATATASAANATNAAQPSATTQEHTGATAATPLAPSVRWTLPRDRALPPTMKQRIRAEAHGSSPATRHLSADPASATRATTASHHTAPEGDSPAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSQ2</accession>
    <name>A0A7K2ZSQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF881 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001834">
        <property type="protein sequence ID" value="MYW35327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029670531" evidence="2">
        <location>
            <begin position="29"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="239" mass="25313" checksum="282C9C32685C7AAF" modified="2021-04-07" version="1">MWAARGLTAAVFALAGLIFVTSANTAKGTNLRSDSSLLKLSDLIKERSENNAELNDSVASARADVDALAQRDDGSTEAEDAKLKALEKAAGTTKITGDAVSVTLNDAPPDATANPGYPEPQPNDLVIHQQDLQAVVNALWQGGARGIQVMDQRLISTSAVRCVGNTLILQGRVYSPPYKVTAVGDPGKLKQALNNSTAIQNYQLYVKAYGLGWKVDEDDAVTLPGYSGTVDLHHAKPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z607</accession>
    <name>A0A7K2Z607_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000012">
        <property type="protein sequence ID" value="MYW27774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="19139" checksum="BB021D78FC24A0F2" modified="2021-04-07" version="1">MSEYDEEAAGEALRKAAELLPDDGTDDGAEAAQQAAQEALRALPGTPEPGWTPEQEKQIQAMVHELRTVRQMDRPGAGLLRRRRQDQARKRYVALAMFSDPQLVDEAELRMWKQNMTVAVLLEFAVSDMGRDDVQSAVTRLEIVHAATYADLTEFKQKMADGEQDDNPDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6U1</accession>
    <name>A0A7K2Z6U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000085">
        <property type="protein sequence ID" value="MYW28065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16474" checksum="803302F82CD54F64" modified="2021-04-07" version="1">DVGVTGWADRPVDALSGGERQRVRLAMALAQDAPVLFLDEPTTYLDLRHQLEVLQTVVRLRAERRLTVVMVLHDLNHAARFADRIVALREGRIAADGPPGEVVTERLLAEVLGVQGRVGIDTEGGWPVCYPDHPLDPLQLLWNENHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Z6</accession>
    <name>A0A7K2Z6Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2469 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000098">
        <property type="protein sequence ID" value="MYW28083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003965949.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="63983096"/>
    <dbReference type="GeneID" id="66958244"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="12305" checksum="BD50D73EAF19370E" modified="2021-04-07" version="1">MSAEDLEKYETEMELKLYREYRDVVGLFKYVIETERRFYLTNDYEMQVHSVQGEVFFEVSMADAWVWDMYRPARFVKQVRVLTFKDVNIEELNKSDLELPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7G4</accession>
    <name>A0A7K2Z7G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Head decoration protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004195">
        <property type="entry name" value="Head_decoration_D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02924">
        <property type="entry name" value="HDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="13935" checksum="054D08709FE44B79" modified="2021-04-07" version="1">MDLNLKVESFTQDRRDWLGSAHGTDAPVSITLDVSKFTKGTHYPDGYLKSGIPLGKVTSGGKYGPYDDAASDGRQALVGFLFTAVDVDARKVASTSVVGSMLIHCFIRTDKLPVAVDANGKADVAGRVIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7N0</accession>
    <name>A0A7K2Z7N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.75.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044930">
        <property type="entry name" value="Homing_endonuclease_His-Me"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="18708" checksum="030DDA66751E97CB" modified="2021-04-07" version="1">MQRSGPTIVQRFWAKVALPADEIGCLLWTAHLKSSGYGEFTAYGRRNVPAHRFAYELLVGPIPSGLHLDHLCRERRCVRPDHLEPVTPGENVRRGEGVSAINARKTVCPQGHPLSGENLYRKPDGRRVCRACRRDREGGPEFRARRREYLRGWRRRRQQGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7R1</accession>
    <name>A0A7K2Z7R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="12427" checksum="5E0AC61AD4169754" modified="2021-04-07" version="1">MATNGSLNDMEQWRSVVEYRRRKRNPAYTHQTRHSVPAYLDEWEEAILTDVRGPYQSAENARRQASRDASDRGRSARIVRVYVERASLAWEPFDERDPETKKWGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z841</accession>
    <name>A0A7K2Z841_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000194">
        <property type="protein sequence ID" value="MYW28492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073876661.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000194.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046193">
        <property type="entry name" value="DUF6221"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19730">
        <property type="entry name" value="DUF6221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="14667" checksum="93D6C0F914F6E40A" modified="2021-04-07" version="1">MAGNADMVAFVRARLADEEQVALAAGGDRWRCPADVPGEVHDRRGGVAFTVRDSGFDHHIALQDPARTLERIETHRVLLGEYVEVAELDTDRPAQDFRSGRAVGLGFAVRQLAAEYAGHPDYQARWLPRFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z889</accession>
    <name>A0A7K2Z889_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl hydrolase family 109 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_04515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000200">
        <property type="protein sequence ID" value="MYW28551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="3">
        <location>
            <begin position="100"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="499" mass="54757" checksum="94F1006E909F6057" modified="2021-04-07" version="1">MNDDARPGQAPQDLPPHHSGDDTGRPDRQDPSRRSVLWTTAGVAGAGLGLSALTGGTASAAAAATPEAAGAAEAVAAATAVPARQGRTMADVPFDRRSTVRVGIVGLGNRGDSMIDLFLAVPGVRVVAVCDPVRDKTEKAAAKVTAAGQPAPAVYAKGEDDYVNLCRRGDIDFVYVATPWELHFPMAKTAMLNGKHVGVECPIAMRLEELWQLVDLSERTRRHCMQLENCCYGKNEMRVLRMAHAGLFGDLLHGAGAYNHDLRELMFDPDYYEGPWRRLWHTKLRGDLYPNHGFGPVANYMDVNRGDRAVSITSIGTPALGLAAYRKEHMPAGDPSWKESYIGADRTISLIQTAKGRVIRLEHDVSSPHPYSRINSLGGTRGVFEDYPERIYLEPTNTDHQWDDFKKYAEWDHWLWKEHANPPGGHGGMDYIMIFRLMQCMRLGLVPDFDVYDAAVWTAPVPLSHLSIKAKGAPLPIPDFTRGAWKKARSGMDSEKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z898</accession>
    <name>A0A7K2Z898_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000197">
        <property type="protein sequence ID" value="MYW28525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="76" mass="7307" checksum="7961593845C43E6A" modified="2021-04-07" version="1" fragment="single">MTPTVTSGASTTPTVLAVIPARGGSKGVPAKNLAEVGGIPLVARAVRAALAAPEVTDVVVTTDDAAIAEAARTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8C5</accession>
    <name>A0A7K2Z8C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_04535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000201">
        <property type="protein sequence ID" value="MYW28555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="384"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="532"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="639"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="831" mass="89875" checksum="F2EB31D7B1200440" modified="2021-04-07" version="1">MKAVVMAGGEGTRLRPMTSSMPKPLLPVANRPIMEHVLRLLKRHGLNETVVTVQFLASLVKNYFGDGEELGMELTYANEEKPLGTAGSVKNAEEALKDDTFLVISGDALTDFDLTDLIAFHKEKGGLVTVCLTRVPNPLEFGITIVDEDGQVERFLEKPTWGQVFSDTVNTGIYVMEPEVFDYVQADTSVDWSGDVFPQLMKEGKPIYGYIAEGYWEDVGTHESYVKAQADVLERKVDVELDGFEISPGVWVAEGAEVHPDAVLRGPLYIGDYAKVEADVEIREHTVVGSNVVVKTGAFLHKAVVHDNVYIGQHSNLRGCVVGKNTDIMRAARIEDGAVIGDECLVGEESIIQGNVRVYPFKTIEAGAFVNTSVIWESRGQAHLFGARGVSGILNVEITPELAVRLAGAYATTLKKGSTVTTARDHSRGARALKRAVISALQASAIDVRDLENVPLPVARQQTARGSAGGIMIRTSPGVPDSVDIMFIDERGADLSQAQQRKLDRVYARQEYRRAFPGEIGDLHFPSSVFDSYTGSLLRNVDIAGIADSGLKVVVDASNGSAGLVLPSLLGRLGVDALTINPGLDESRPTESADTRRAGLVRLGEIVSSARAAFGVRFDPVGERLSLVDELGRIIEDDRALLVMLDLVAAERRSGRVALPVTTTRVAEQVAAYHGTQVEWTTTSPDDLTRVGREETTIFGGDGRGGFIVPEFSSVFDGTAAFVRLIGLVARTQLTLSQIDARIPRAHVLRRDLATPWAVKGLVMRSVVEAAGDRSVDTTDGVRVVEADGRWIMVLPDRAEAVTHLWAEGPDDASAQALLDEWSAVVESAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8I6</accession>
    <name>A0A7K2Z8I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000217">
        <property type="protein sequence ID" value="MYW28632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="7875" checksum="003FD0E799DF146E" modified="2021-04-07" version="1" fragment="single">MDITRSSPAPMRVVTAPPEAPDRTVLPAAVPLPGSPETVLPATVPLPKPLETVLPATAPPPEPPEIVLPAAVPSPGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8I9</accession>
    <name>A0A7K2Z8I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
            <ecNumber evidence="3">5.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mce</name>
        <name evidence="3" type="ORF">GT040_05000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000220">
        <property type="protein sequence ID" value="MYW28641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015611400.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000220.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15738" checksum="DD200C7144470BB0" modified="2021-04-07" version="1">MLTRIDHIGIACFDLDKTVEFYRATYGFEVFHSEINEEQGVREAMLKINETSDGGASYLQLLEPTREDSAVGKWLAKNGEGVHHIAFGTADVDGDAADIREKGVRVLYDEPRTGSMGSRITFLHPKDCHGVLTELVTSSPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8K0</accession>
    <name>A0A7K2Z8K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000236">
        <property type="protein sequence ID" value="MYW28676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="109" mass="10528" checksum="0B397DCB4B1D6BA4" modified="2021-04-07" version="1" fragment="single">TDAVRRALESFGTPVTVDTPIPGPGAQPSDVGSPGGVQGPVGSPTTGTPGGAGTAESPVTEPPSVPDRQNQPGPDGRTTAPPQVDTSGSYGDTRAPGEADGGPGTRDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8U1</accession>
    <name>A0A7K2Z8U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="494" mass="52947" checksum="2D2EB8EEF3A436E0" modified="2021-04-07" version="1">MASSLTKDSASSGEKTFFGHPRGLATLFMTEMWERFSYYGMRALLPLYLIAPGGLDMNPATATAIYSVYLSLVYLLAMPGGWFGDRVWGPRKTVAIAGGVIMAGHLVLALPWEGTFFGGLGLVAIGSGLLKSNISTMVGHLYDGPDDPRRDGGFTIFYMGINMGAFAAPLVIGTVGENVNWHLGFALAALGMGLGVLQFLLGTKHLDEKSLIVPKPLSKDERASTLRKSMIWLGIAAVFYIGTVVTGVYTLNWLLVPITIAGLVIPVMVLVRIKRDKELSATEQSKMSGYIWFFVAAAIFWMIYDQGGSTLAIFAESSADNSVFGWDFPVSWYQSVNPVLIMALAPVFAAFWLALNRRGKEPSTIVKFSSGLVLVGASFFVFLMPLTIAGDGHKAAAMWLVAIYFIQTVAELTLSPVGLSVTTKMAPAKYASQMMGVWFLAVTAGDCTTGLLSLAGVGLNGTGVVALEATLAVVAGIAIFMYRGKVKQLMGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z947</accession>
    <name>A0A7K2Z947_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_06185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000276">
        <property type="protein sequence ID" value="MYW28871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="37934" checksum="8019E470D811E461" modified="2021-04-07" version="1" fragment="single">MTRAISLHHVSKSYGRDRRAVDRFTLSIEPGEFVVLLGPSGCGKSTVLRMIAGLEEISEGELLLDGEFANHIPPRTRGMAMVFQNFALYPSMTNRANIGFPLKLENPREDNRARIEATARMLGIEHVLDRYPAQLSGGERQRVAMGRAISRRPSVFLMDEPLSNLDAKLRNHLRAEIALLTRELGVTTVYVTHDQAEAMSLGDRVAVMRGGVLQQVSPPREVYALPENVFVAAFIGTPRINLLQAVVHAPLEGRMSIDLGRQRLALPEPLSPDHQLLRIQQGRRIIVGLRSEAVRIAPPSHARPGEVALSGIVEHVEYQGHEALVHLNTGSRPAVVPDLESAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z960</accession>
    <name>A0A7K2Z960_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000295">
        <property type="protein sequence ID" value="MYW28900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="30343" checksum="C310443DB6FD72A5" modified="2021-04-07" version="1">MLTTAAATGVGAAALHAAHGLRKQVAGLRTELAEGCAPGASVPPQSRSAATPPEEIRAAVAEALAEERERELAEARAFWAAQEARDAADAPSLLGGMPVLGEDAPFYLPRQADFAGLESLDLESAEAMEELAELSERTLAEHEAGEFAGEFMDLPEIADHPEDSPELAAARRRHPSHPDFVPVQTPVVTDHERTVSRLEELADLATELTDVRPGPLGTLDVYVFADGTTLCMTPGHRETAERLADALRAGRQPVLLGGSGVSGAYALTFSCGEDNVYILADRVIASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9A5</accession>
    <name>A0A7K2Z9A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000297">
        <property type="protein sequence ID" value="MYW28913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="17418" checksum="CCA4F0CC591750CB" modified="2021-04-07" version="1">MIITYDHTDKAGRPVTLHAVDADNWRAVADCAPHDDQRAWVPALAARYLVLTAREDTWNSLAVLAGDEVTGHIMWARDEDGSYWIGGMLIDAAHQGRGIGAAAVRTLATWLSAQEGCTAVRLSYAPSNEAAAHLYAALGFRPTGVEEDGEMVAEWGGAMVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Z2</accession>
    <name>A0A7K2Z9Z2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gatA</name>
        <name evidence="9" type="ORF">GT040_07840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000361">
        <property type="protein sequence ID" value="MYW29191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="500" mass="52515" checksum="1A77126FF8EA59E5" modified="2021-04-07" version="1">MTDHSTIIKLTAAEIAAKIASGELTAVEVTEAHLARIDAVDEKVHAFLHIDREGALAQARAVDAKRAAGEKLGPLAGVPLALKDIFTTKDMPTTVGSKILEGWVPPYDATLTQRLRAADVVILGKTNMDEFAMGSSTENSAYGPTGNPWDLTRIPGGSGGGSSAALASYEAPLAIGTDTGGSIRQPAAVTGTVGVKPTYGGVSRYGMVAFSSSLDQGGPCARTVLDAALLHEAIAGHDPLDSTSIDAPVPPVVEAARNGSVQGMRVGVVKQFRGEGYQAGVLQRFDESVELLKSLGADIVELDCPSFDLALSAYYLIAPSECSSNLARFDAMRYGLRVGDDGTKSAEEVTALTREAGFGDEVKRRIILGTYALSSGYYDAYYGSAQKVRTLITQDFEKAFEQVDVIVSPTTPTTAFPIGERADDPMAMYLADLCTIPTNLAGNSAMSLPCGLAPEDGLPVGLQIIAPAMKDDRLYKVGAAVEAAFVEKWGHPLLEEAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA11</accession>
    <name>A0A7K2ZA11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000362">
        <property type="protein sequence ID" value="MYW29197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8061" checksum="3EC0F97C3B57D554" modified="2021-04-07" version="1">MYATQALTHVVPLAAELDKNKVTPGVLGFLVFAALAVGVWQLMKSMNRHMGRVNFEEAPEPGAASAAEGTPGAPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA76</accession>
    <name>A0A7K2ZA76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septum formation initiator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_08055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000369">
        <property type="protein sequence ID" value="MYW29234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="17955" checksum="E4DD8547B41B9E03" modified="2021-04-07" version="1">MAGKDRDRFSTATRLRLLGEQTAARVYRSQNRRQARRSRLTGRAAFLALVVCSLVVALAYPMRQYVSQRDEIAEQERLSQEAKARTEELRDEKARLQDDAYIMRLARQHLHYVLPGETGYIVADPDAAEDRRGESGENHRPWHSNVWDGVDSADRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA81</accession>
    <name>A0A7K2ZA81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000365">
        <property type="protein sequence ID" value="MYW29212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="60"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="372" mass="39640" checksum="DD02D078B784BDD3" modified="2021-04-07" version="1">MEPPVLPETFPLATVGLEDAVARQFRLLEATAAHFEGDQLFSADAGVVPGLGRPRTTARVEAVLADFFGAEDAAFVQGAGTGAIRAALTGAVRPGEELLIHRAPVYRSTEVTLRGLGVRTVEADFNDLGALREALASGRFRWAYVQHTRQRLGDSYDPAEVIAACRAAGVRTVVDDNYAVLRTPAAGVEMGADASCFSLFKLHGPEGVGLVTGARDLVARVRGDNYSGGGQVQGHQALDALRALTHVPVVWAVQSRVGAEVAERLAAGEVEGVAQVRIANAQDRCLLVRLDRPVATRLPAVAARFGAAPYPVGSNSRYEIAPLFYRMSSSTLDDAPELADWTVRVNPMRAGADLVIDILRRSLAALNEPKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA87</accession>
    <name>A0A7K2ZA87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000372">
        <property type="protein sequence ID" value="MYW29248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="105" mass="11114" checksum="1DB72E03905E0F1B" modified="2021-04-07" version="1" fragment="single">MEPLRSTDPARIAGYRILGRLGAGGMGVVLLGRSPGGALVAIKLIRAEYADDAGFRTRFRREVAIARQVRNRWAVPVVDADTEAAAPWLATEFVPGPALSEAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAA2</accession>
    <name>A0A7K2ZAA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000369">
        <property type="protein sequence ID" value="MYW29232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="313" mass="33065" checksum="BFB81DD5AE4C1828" modified="2021-04-07" version="1">MTRVAAVDCGTNSIRLLVADADPATGSFTQLDRRMTIVRLGQGVDRTGRLAPEALERTFAACREYAAVIEELGAERVRFVATSASRDAENSEEFVSGVRDILGVEPEVITGDQEAQLSFDGATKELTGGDHLAKPYLVVDIGGGSTEFVLGSDEVEAARSVDIGCVRMTERHLTVDGTVMDPPTHDRVAAIRTDIDAALDVVAGTVALTEAATLVGLAGTVTTIAGIALELAEYDSEAIHHSRVSRGQVRAITEHLLQATHEERAAIPVMHPGRVDVIAAGALVLLAVMERTGAHEVVVSEHDILDGIAWSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAB7</accession>
    <name>A0A7K2ZAB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000379">
        <property type="protein sequence ID" value="MYW29269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="96"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="28437" checksum="8EE1CA1FCE295B51" modified="2021-04-07" version="1">MGLRAQVRTRDGWAVQHAVVTVTDMTGTQVLRAAADEDGAVRTDGPLPAGAYTVIVTAVGYAPAASTALVTASGRIEGGQIVLARQGGVELPPPGAWSLDPVHSSVGAVAQHLGISSVHGRFTDFGGRITIAEDVSRSRVDAVIAATSIDTGNGMRDKHLRSPDFLDVDRYPEITYRSTGLAPAGPDRWTVHGELTMHGLSRPVDLDLTYLGTGPDPWGGVRAAFHAAAQLRRDDFAMNYNQVVQAGISAIGTTLRVELDIQAVQGDALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBF5</accession>
    <name>A0A7K2ZBF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000473">
        <property type="protein sequence ID" value="MYW29663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="73" mass="8106" checksum="173E71C7D0E5EC6C" modified="2021-04-07" version="1">LVGEPPMAYLTGWRLALAADLLRESDATVEAVGRKVGYSAPFAFSTAFKRVRGVSPQEYRGNLPERQQNLPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBJ5</accession>
    <name>A0A7K2ZBJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046218">
        <property type="entry name" value="DUF6251"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19764">
        <property type="entry name" value="DUF6251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="12602" checksum="258A2410A38A48FF" modified="2021-04-07" version="1">MNNLPEPVRVVQLPDGTPAYSDHLPATYQPINTAPQVIHVHQAPPDRTVQRLALGSGMGAGAVAAGVYFGPLLVGVLTAIAANLALLALVASVCAWGVVTVVKSVSGSDGKAATSSPRKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBP8</accession>
    <name>A0A7K2ZBP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000492">
        <property type="protein sequence ID" value="MYW29759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="247" mass="26485" checksum="5314819E749644BD" modified="2021-04-07" version="1" fragment="single">MRLHRLTLTAFGPFGATQEVDFDALSSAGLFLLHGPTGAGKTSVLDAVCYALYGAVPGARQSPGATLRSDHAPADLPTEVLLELTVGGRRLEVTRSPAQPRPKKRGGGFTQEKAQSRLRERDPKGDWQGLSKSHQEIGEELAQLIGMSRDQFCQVVLLPQGDFARFLRSDAEARGKLLGKLFDTRRFAAVEERLAELRRAAEARVRSGDEQILALAQRIAQAGGPAATEAAPPTVRAGEPGLAEAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCB2</accession>
    <name>A0A7K2ZCB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000534">
        <property type="protein sequence ID" value="MYW29905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7113" checksum="9CA72FB579286DA5" modified="2021-04-07" version="1" fragment="single">MRVYVPLTLSGLAAAHASGEVGPGPLTAYAVTPGLREWYVSDDIEELEYAALNRAAAASLRLIAGNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCV7</accession>
    <name>A0A7K2ZCV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000603">
        <property type="protein sequence ID" value="MYW30173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="16454" checksum="5180725CB45A52D0" modified="2021-04-07" version="1">MAPGSALIPRLMDLSPGTEALRYCFALPAHPESVAGARQLTRARLESWKLGADVYDAAVLIVSELVTNAVVHTASTRVVCELRCLGRRLRIAVQDQGHQPGGPRLRRCSDDEHGRGLLLVDTMSSSWGSHDAGDHSGRIVWAELPHGVEQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD14</accession>
    <name>A0A7K2ZD14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="5" type="ORF">GT040_13285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000614">
        <property type="protein sequence ID" value="MYW30233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="402" mass="42396" checksum="869817762B0BC380" modified="2021-04-07" version="1">TARSTGVGELDRVLGGGLVPGAVVLLAGEPGVGKSTLLLDVAAKAASEDHRTLYVTAEESASQVRMRADRIKAINDHLYLAAETDLSAVLGHLDAVKPSLLILDSVQTVASPEIDGAPGGMAQVREVAGALIRASKERGMATLLVGHVTKDGAIAGPRLLEHLVDVVLSFEGDRHARLRLVRGVKNRYGATDEVGCFELHDEGITGLADPSGLFLTRRDVAVPGTCLTVTLEGKRPLVAEVQALTVDSQIPSPRRTTSGLETSRVSMMLAVLEQRGRISALGKRDIYSATVGGVKLTEPAADLAIALALASAASDTPLPKNLVAIGEVGLAGEVRRVTGVQRRLAEAHRLGFTHALVPTDPGRVPSGMKVTEVADMGDALRVLPRRSRQETPQPRQEENARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD16</accession>
    <name>A0A7K2ZD16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Baseplate protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000607">
        <property type="protein sequence ID" value="MYW30198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="158" mass="17004" checksum="4E28BF2D103FEECA" modified="2021-04-07" version="1">MSGDGHTGALRGSGSGFIGRGWGFPLRTGATGGIALVERDKEIEEAIGLILGTAPGERPMRPEFGCGIHDYVFAPGDGATAGRIAQEVRMSLERWEPRIEVTDVVIAFDAIEEGTLYIDVRYTVRATNDLRNLVFPFYTIPSEEGSSQASQGSQAEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD73</accession>
    <name>A0A7K2ZD73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilus assembly protein TadE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000651">
        <property type="protein sequence ID" value="MYW30303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029607715" evidence="1">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="10923" checksum="A866959F8D255D4B" modified="2021-04-07" version="1">MTAEAAVVIPVLVAFAMALLWALAAASVQIRCVDAARAGARAAARSEPEAAVLTATRDAAPHGARVAVGRAGELWRVTVEAPTPGPAALAVTLRAEAVALAEDTVGGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDA4</accession>
    <name>A0A7K2ZDA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TauD/TfdA family dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_13850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000655">
        <property type="protein sequence ID" value="MYW30343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="10"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="272" mass="30189" checksum="CFC7CF73E55E6F3E" modified="2021-04-07" version="1">MTTATTALEIRRVGPRIGAEVIGVDLTRPVGEATADRLREAFEEHKVLVFRNQHLTPDQHVEAVRIFGEPFDHPTAVKDSVNPLVYPYNVRQTGKASQWHIGGLWRSPVFAIESLTYEEVPELGGHTLWADLQAAYDDLSEPFKVLLASVSAAYDADPQNYAQGKERTAVGETVEHPVVLEHPVTGRKGLFISTSALRLTGVTPEEGKVLLDHLLRHASSPDYTIRFGWNPGDFVLWDNQATWHYAVDDYGDGARVYRKVIGVERPQAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDB7</accession>
    <name>A0A7K2ZDB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ORF">GT040_13745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000654">
        <property type="protein sequence ID" value="MYW30322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="136"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="462" mass="51154" checksum="FB48B0DE66EDD076" modified="2021-04-07" version="1" fragment="single">MTLPTETAHPELEGLGTYEFGWADSDAAGAAAKRGLSEAVVRDISEKKNEPEWMLKLRLKGLKLFGKKPMPNWGSDLSGIDFDNIKYFVRSTEKQAASWEELPEDIKNTYDKLGIPEAEKQRLVAGVAAQYESEVVYHQINEELEAQGVIFMDTDTALKEHPELFKEYFGTVIPVGDNKFASLNSAVWSGGSFIYVPKGVHVEIPLQAYFRINTENMGQFERTLIIVDEDAYVHYVEGCTAPIYSSDSLHSAVVEIIVKKGGRCRYTTIQNWSNNVYNLVTKRAVAYEGATMEWVDGNIGSKVTMKYPAIYLMGEHAKGETLSIAFAGEGQHQDAGAKMVHMAPNTSSNIVSKSVARGGGRTSYRGLIEIGEGAPGAKSNVLCDALLVDTISRSDTYPYVDVREDDVSMGHEATVSKVSEDQLFYLMSRGLTEFEAMAMIVRGFVEPIAKELPMEYALELNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDN7</accession>
    <name>A0A7K2ZDN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5133 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000667">
        <property type="protein sequence ID" value="MYW30428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033457">
        <property type="entry name" value="DUF5133"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17196">
        <property type="entry name" value="DUF5133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="10251" checksum="080CA842F350A9DA" modified="2021-04-07" version="1">MLLPRPDTIRTLLARYYELQLEHSQDSHYELQRSLEDVTYTLCVSTGTRTVQDALLAAEAILRTSPADQQPALQIPEQRNTPPGPASHPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDS9</accession>
    <name>A0A7K2ZDS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000685">
        <property type="protein sequence ID" value="MYW30482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="31783" checksum="976852692FAB1CBE" modified="2021-04-07" version="1" fragment="single">VRRLADRGIAALVVELGPRFSRLPASIVDAARAAGLPLVQLHREVPFVAVTEEVHTEIVNGHYALLQQAEEVHRRATRALLDGGGVPQVLGILADFTANPVFLETPDGQLLYAASTGTGPVGADPLQVWEGMRGDRAARESPPVGALLVDVPGGGPDTGAVRARLVLLAVSGPLATVHRMAAERAAGLLAVVLMQARQEEELAARGRGDFLTDLAEGRITPEDAPAQARVLGFRPGDTPLLPVVMRLAPELSPSGNWALLARAVLEELASVGVPVLLGVRPVEGRVPLLLGLRSEGERTAVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDW1</accession>
    <name>A0A7K2ZDW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000714">
        <property type="protein sequence ID" value="MYW30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="33046" checksum="861A8D7D2B83820E" modified="2021-04-07" version="1">MRDTPGGRLTHHARGAPLRGRVAVVTGAARGIGEALAHSLSDAGMDVALIGRERETLQVVADSLPGRSICVEADVTDRTALADAALRVETELGPASVVVANAGIAVSGPFDHTAAELWQRVIDVNLTGSANTVRAFLPQLTAARGYFLQIASTAAFGAAPMMSAYCASKAGAESFALALRGEIEPDGVQVGIAYLHWTGTDMLTGIDDHPVLEALRRNQPRPARRVHSPDRVARWLTQGITHRAPHIYAPPWLRWCQPLRPLFPALVARVARRELRDRPGEQLSSPAEVLGAGGRADWYSYQAAPRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEA3</accession>
    <name>A0A7K2ZEA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AfsR/SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000729">
        <property type="protein sequence ID" value="MYW30662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="660" mass="72153" checksum="35058135F517AA63" modified="2021-04-07" version="1">FRTDTDEETAAACAEICRRLDGLPLAIELAAARLRMLTPRQIADRLDDRFRLLTSGSRTVLPRQQTLRAVVDWSWELLDAEERAVLRRLAVFSGGCSLAAAEEVCALPGRDGTVAVDSLDVAGLLGSLVDKSLVVAAPGDDGEMRYLLLETVGEYAAERLDEAAEREAVARRHLVHFRELARITGPKVRGAGQRDAIAVFQREYENLRTAFRHAVALRDEHEALCVVLSMAWYWMLRDLRADARQWGEAAASLGPDPFAPGVRAPSLPERATDRPPPMDDEQLAEARRGVGLIQLAGQDLALSEWSTPEGERRLRIIVDTYRPGQPQTCRMPGTLWMYAVLLSGDTARLYELLHETVRACQELGYEWELGSALHTRANFLANDPERVAEARADADESLEIFTRLGDDWGAAEALSSRGEANERAGGFTAALRDYAEAVEYAQKIGAQSQVALLRARYAGALIELDRLQEAEAILRDITENGRQSGHEATPMARMHLGFALGLQGRVGEARRETELVREDFGSRDVAIFGGFVFGVLAWLDNLEGAHASALSNALTALDSSRDRLSMMVAPQMRSAHLTTAARALAGLDASGAAEDAARLLALQAALLPKGHVPTMMERRTLAHAEEAVRARLDDAAFTEAYEQGGGLTLDEATALAEAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZER8</accession>
    <name>A0A7K2ZER8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_16445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000766">
        <property type="protein sequence ID" value="MYW30822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="283"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="424"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="682" mass="73241" checksum="4A50DB422759AAE2" modified="2021-04-07" version="1" fragment="single">MKPTESAAPVSRLQGFVGLTSPVGAAAIGIAALLLAAGFYRTVQDGHALFPGGTVGWSIAVLTGIIVGHLVALGRDRWWGGTGSGAALTLAVLLLYGWLPAGLVSLVVVVLVGSARRHRWWQGLLHGAVDILGIAAAALVLAAFGEVPTVERPWLPLDWGIAAVPELLLTASTYLLVTRVLLWYAGAPQNGGLPTIARTALLRQGLVAVALLGLAPLICVVAMSMPVVLPLFAVPLIALDSTLWIARARAEEQLRDPLTGLPNRQWLLERTWSALEDAESVGTRSALVLIDLDRFRAVNDTLGHLAGDRLLLQIAERLRLALPPGAEAARLGGDEFAVLLPQADSTTSAQRVARHLVAELSSPLDLDGLVLVLEASAGVAVYPDHALDAEGLLRRADVAMYQAKRDRTGVEVYESKRDSNTPDRLGLLGDLRRALDAGDVELHYQPKVRFDGQVAGLEALVRWVHPERGRVPPDEFIAIAESSGLMPHLTEYVLETALAQVARWRAQGLFVPVAVNVSPRDVHTPGFAGGVAARLARHGVPASALQLEITEHVLLEDPQRAADTLAGLTAHGVKMSLDDFGTGYSSLVHLRRLPVSELKIDRSFVARLALDHEDGEIVRCTIDLAHSLGLVVVAEGVEDDETWERLRDLRCDAVQGWLVAAAMPPQETTAWLRARGRHGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF17</accession>
    <name>A0A7K2ZF17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl Co-A mutase-associated GTPase MeaB</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">meaB</name>
        <name evidence="2" type="ORF">GT040_17130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000806">
        <property type="protein sequence ID" value="MYW30954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030566206.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000806.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="35453" checksum="6948D912A52A7047" modified="2021-04-07" version="1">MAAKIDIDSYVQGVLDGKRAFVARAITLVESTRAEHRVLAQELLSRLLPHAGKARRIGISGVPGVGKSTFIDALGTMLTGLGHRVAVLAVDPSSSRTGGSILGDKTRMERLAVDPAAFVRPSPTAGTLGGVAKATRESIVVMEAAGYDVVLVETVGVGQSETAVANMVDTFLLLTLARTGDQLQGIKKGVLELADAIAVNKADGPHERDARSAARELAGALRLMHPVDAAWTPPVLTCSARESTGLDTLWERLEQHRTVLESTGRLAAKRRDQQVDWTWTMVRDELLDSLRNHPAVRKLAPELEQRVREGTLTATLAAEEILGVFRGDEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFI7</accession>
    <name>A0A7K2ZFI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000842">
        <property type="protein sequence ID" value="MYW31086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="31592" checksum="7C29F84ECF190A31" modified="2021-04-07" version="1">QRPQAANWGADAPRGHEEHDATGQFARPTGPGQDQAFNAPLNQDPGATSQFARPDFNAPLQQNQHQGQSYGHQAQDPAATAQFARPDFNAPLQQNQGQQLPAPRQRGPEGNGFGAPRPSASPAGEAPYRPALPQQPEALPPAGPGDGRTPLYDTLETNWFHGPGQGGQQGAEPQAPAAPEPTGVPVPPMPQRGAAEAPVTSSWRASPNDELVRQAERVKKPAAGGVTTSGLPRRVPRANLVPGTAQQQNHQSGPQVSRAPDDVRGRLTNLRRGIQQGRQANNGPSTGSIHLGPTHQQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFK0</accession>
    <name>A0A7K2ZFK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18095</name>
        <name evidence="2" type="ORF">GT040_27580</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000857">
        <property type="protein sequence ID" value="MYW31133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001296">
        <property type="protein sequence ID" value="MYW32935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="416" mass="45788" checksum="7671CC62BB63E48A" modified="2021-04-07" version="1">MWHTGYGIEINLSLPDLGHPYRPDLLREITARVSERDPQLLECLAHHDNRACLSESGGKSPWMFIRRGRAGGRRPLVAAHLPLTHKATPQESAQHKATKERVVATAGRYGLDAAAEVPVANRRSVSDAVVTGPAGLRIGWEIQYHHLSPSSVHRRSVNAVENGVTPLWVAKDRTASLIDRAPRARVDDMPWRDIADGKEMVIRGGYRHLEVWRCVPSSERHCLVSEGAGHCGAIHADWFVPALCLPERKPVLIEDLVLRSATGESVPVYVPSRGSGRAGRHMWVSAADRALWEEIVDEKTPLPMAPADDDDDVITFAEQEIDRSCRAGEDGWFASDARPLRDLAQPTGGFTLPRLPPQRPGDATRITPVERAAASAALGCPPWELGLCAGCDQMMRRYGPYAAMYCNVCRATLNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFL1</accession>
    <name>A0A7K2ZFL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin-antitoxin system HicB family antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000858">
        <property type="protein sequence ID" value="MYW31141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15040" checksum="F7906ABA392E9330" modified="2021-04-07" version="1" fragment="single">MDLTPYVDSLRRELAVAAEAGGDEARALAERLTAPLESATRLTMLHVLSAAMDEITRELAPGSVDVRLRGLDPDFVVTLPQTGDGATPEPAEPVQPLKAPADGDEGAAARVNLRLPAHLKARAEEAAAGEGLSVNAWLVRAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFW0</accession>
    <name>A0A7K2ZFW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000871">
        <property type="protein sequence ID" value="MYW31257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="343" mass="36801" checksum="C13CA82333919B8A" modified="2021-04-07" version="1">MAKPGYGKRTASDQHPRTPNDFSFLPTRERYLAGFIDRLPDEAAMGVKVLAQQLPLYGQQAIGSALRALSVAGHLRRVRCEVGREGQVRWVSRTFWSRTARDNEWWNAYLATERARFTAGSEQASPAAASATAPPPPPWVPEEPPPTGHQHPDAEAKAESVSVSVPQQRTTTPPTQPQAPAPEPPHAPGPSPAYVALAQLGQVDHRVGLSAADCAALEGLAAAWLERGATAEYVVHALTAGLPQAVDSPIGFVRRRLETKMPSHQPTTGPAHPPPPGAPAPRVLVECAECGAPGRPEALPDGLCRPCRSGTDSPEERTRYDGLPGQSDITTYVSELRNRLKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGZ0</accession>
    <name>A0A7K2ZGZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1304 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000972">
        <property type="protein sequence ID" value="MYW31617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009732">
        <property type="entry name" value="DUF1304"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38446">
        <property type="entry name" value="PTHR38446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06993">
        <property type="entry name" value="DUF1304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="12690" checksum="28950C0B820889DB" modified="2021-04-07" version="1">MHITAQVLVALVALIHAYFLVLEMFLWDTDRGRRAFGTTPAFSRESATLAANQGLYNGFMAAGLVWGLIAADPVAFQAQVFFLSCLIVAGVYGAATVSRKILYVQAVPSALALGAVLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGZ6</accession>
    <name>A0A7K2ZGZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000974">
        <property type="protein sequence ID" value="MYW31631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029724786" evidence="1">
        <location>
            <begin position="30"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="436" mass="46824" checksum="16ABE6673004EE50" modified="2021-04-07" version="1">MARPGISRRRALSAGLWTALAGVTATACADGAPDDADGPLTLWSALRGTDTLVAAWNELHPDDPVDFSPMTSGLAGGNAKLSNAARAGNAPDIVTLVDADLPSFAIDGVCADLTDFVTPRLRERLGPQAWTNGVLGGRTYGIPVDLGPMLFAYREDILIRHRIEPPTTWEEFGGAAGRLKRDAGVDLTTFHPNAYNVLAGHTMQSGGQWFAIEDDTWVLDFLGGPTRRVAEFWQGLVDEKLLMFAPGSSQQWLSALARGQVASHLVGPWGLAALVRSVPGTSGRWRVAPLPRWEGGEDVVGTDGVSVHAITAGSRRKRRAMRFLEWMTTSPQAITARLSGGRSSILPADAGLVANASREFDTAFYGGQDVYRLVADQARLLRTGWTWGPRMQATATSLHQGLARLEYGTTITEALRTAQSETLPDMRSLGLSVRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH50</accession>
    <name>A0A7K2ZH50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000984">
        <property type="protein sequence ID" value="MYW31674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="19654" checksum="FA3B0E86FE6CED12" modified="2021-04-07" version="1">MDELTAPEGFLLRPWLPADASAVLRAFAPAEMDRQSDRPVADRADALAWIADRTRERGARTGYSWAVVGEEGEAIGCVAVRAVNRAHDTGWVSYWTTEAARGRGVAPAGVRAVARWAFGELGLYRLELGHRTDNPASCRVAVRAGFAPEGIERGKLRYGDVRHDVERHARLADDVVNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHD8</accession>
    <name>A0A7K2ZHD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ComEA family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001010">
        <property type="protein sequence ID" value="MYW31735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="8611" checksum="F9BB70CAD6C585EA" modified="2021-04-07" version="1" fragment="single">RATGADPVPRPVAGAPPSPPPEPAGEIVVDVSGKVHHPGIQRLPVGSRVADALRAAGGVRAGTDVTGLNRARVLMDGEQVAVGLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHK0</accession>
    <name>A0A7K2ZHK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001017">
        <property type="protein sequence ID" value="MYW31795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="450" mass="48763" checksum="44EC72DEB7503C1A" modified="2021-04-07" version="1">MDRHHHFVEQDAVTRLSLPPAVASARCGWVGTPDSLSRSTTPIGSACVRDVSAFVRGRIMESGHLGRPESAVSDRFATAAAYAVAGAVHLLTAGLFIGSLMMIVLKFDTFIQPLLGLIPLGLALALRPRLGRLAPELPVLREADAPALFALLHRTADSAGARRVDTVQLTAEFDMRVISYGVRRRRCLVLGLPLWSAYSPQQRIAAVTQAFGEGGPRNLRSGVFVGSVLRSVTAGAHTLRSGDAAAATPSADAHFLYTGEIAAASRRFNARSRRSDWALWIPRVTAAATSRLLLRCTRSAARRAQFEADDAAARTASSPAALAALRDRDLARATYLEMHRLAVEKKTLVKANASEKPQDDLWENIGRHAAVLREQRETSRPLVPAPRTGLPDPASHDVVAQRITRLTEAPQHPATITLDESGRALIEDELRRPKQEVERLVLRDGMPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHN1</accession>
    <name>A0A7K2ZHN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001023">
        <property type="protein sequence ID" value="MYW31838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511058.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001023.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="239" mass="26066" checksum="8E370EF35B51D7E9" modified="2021-04-07" version="1">MHTYPTQAVILAGGQGSRLRPYTDDRPKPMVEIPGTGTPIIGHQLSWLAAEGVTDAVVSCGHLAEVLQEWLESAVLPLRVTTVVEKEPLGRGGGLKYAAQRLPDPEQPWYATNGDIWTRFSLREMAAFHGERDATATLALARPRIPWGAVETDAFGHITDFIESPPSPYLINAGVYVFSPAFTGMLPDQGDHERTTFPRLARERRLAGYPLPHGAYWRAIDTAKDLTEAARELGAQGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHQ5</accession>
    <name>A0A7K2ZHQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyamine aminopropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_21915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001030">
        <property type="protein sequence ID" value="MYW31858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="226"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="461" mass="48823" checksum="39E4457EA418E48A" modified="2021-04-07" version="1" fragment="single">MIDQQVSLRGGAARLPVRPRTGRFLVLAAVFVCAACGLVYELELVALASYLIGDSVTQASVVLSVMVFAMGIGSLLAKRLRCHAAVGFGLIEAALALIGGSSALVLYASFAWLGESQYALVGFSLAIGVLIGAEIPLLMTLIQRVDRQDAGGAVADLFAADYVGALVGGLAFPFLLLPMLGQLTGALLTGAVNAAAGGALVLWVFRRDLTPRSRRLLVVVNVSVIAVLATATVLVDDFEQAARRAVYGDQVRVAVQTGVQEVVLTGADRDSLGLYLDGRLRVSARDEHRYHEALVHPAMDGPRARVLILGGGDGLAAREVLRYGDVRSVTLVEIDPAVTRLARTDPALSELNGHAYRDPRLTAVGADAFTWLRADHHRYDVVVSDLPDPGITASTKLYSAEFYGLIAEALAPRGRLVVHAGPPEVRPRTFWTVDASVRAGGLATRPYRIPGRPSGHPSGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHT9</accession>
    <name>A0A7K2ZHT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenosylcobinamide-GDP ribazoletransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001059">
        <property type="protein sequence ID" value="MYW31914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6231" checksum="EF2FA0D8712CE93D" modified="2021-04-07" version="1" fragment="single">MTSLNSHGLRFAFGTLTVLPVHVTRWDRATARAGMLCAPLAGLVVGLLAAGLGALSLLAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHW2</accession>
    <name>A0A7K2ZHW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="10900" checksum="95518C122F836C5A" modified="2021-04-07" version="1">MSWVVGTALLLGMLLIAMGTLTLGTGWIVPTARRHVTRPQLHGCGALLMGASLVLQSLLYFGALPSVSWETRFYGGNALLLGGMLLLLVSQLLPLRSSRDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIN5</accession>
    <name>A0A7K2ZIN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001112">
        <property type="protein sequence ID" value="MYW32212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15829" checksum="1297B44A8FBE3CD5" modified="2021-04-07" version="1">MAESAAVEFRIDRRSGIATYLQIVQQTKQALRLGVLEPGDRLPTAREVVEATAINPNTVLKAYRELEREGLVEARRGLGTFVRRTLGGAGEASAADSPLRGELADWARRARAAGLERDDVGALFSAVLESTYDTTPGDTDQGDQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIQ2</accession>
    <name>A0A7K2ZIQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001113">
        <property type="protein sequence ID" value="MYW32218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="55" mass="6404" checksum="993379B1B685D044" modified="2021-04-07" version="1">MPECVRSAVRRRPSVPRPARVRGPVDRHQQRRLFRIRIYTERPSDPQPVPGDGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIS8</accession>
    <name>A0A7K2ZIS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001118">
        <property type="protein sequence ID" value="MYW32248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="170"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="302" mass="31081" checksum="89AEEADD3D9243DC" modified="2021-04-07" version="1">MTSDLPDPAELGALVVGVDASPPARAAALWAAAEADLRGQPLTVVHAADIEGRSVLTSAETLQALWDAASDVLAETVEAVRGKHPDLTVTKELSRGEAVASLHAAAGDRGTIVVGSRGLGGFASLTLGSVGLGVAARTEVPVIVVRGEPDRAATGVVTAAVHGTSDLDWLLIAAAEAHVRNASLRLLSVRNVLTYVGRFTTMLDSVGEITEEKVHETAAMADRIRKRYPGLTVTHDVETGTSVPGILVEATSITDLLVMGARHRVIGGGSALGRVAHALLHHGHCPVQIVPPGYAATDDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ83</accession>
    <name>A0A7K2ZJ83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001158">
        <property type="protein sequence ID" value="MYW32398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="51"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="27468" checksum="738C08509622B139" modified="2021-04-07" version="1">MKDPSFRRSLTLFRAFLREGEDPTTVYTLLARDAADQVERYEPLQGKIVADIGGGDGYFTREFRRRGAQSYLFEPDVGELGDPRSRGPRDTVVADGYLLPLADGVADVAFSSNVLEHVADPHTFISEMARVTRPGGLIYVSFTNWYSPWGGHEWAPWHYAGAERARARYERRTGHPAKHRLGENLFRIGVGPTLRHVRGRTDVDLVSARSRYWPVLPELVTRVPGLREFATWNLLLILRRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJG3</accession>
    <name>A0A7K2ZJG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001182">
        <property type="protein sequence ID" value="MYW32471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="23195" checksum="5081A05220F27F15" modified="2021-04-07" version="1" fragment="single">PARALPSALRLADLTPDQADRAKERLGIPPHALAPGHDRHPLTLRLLAEVREALPPGVPGRPDTEDVFGAHLDLMCVRIAVRITAAAGEQPRGTAVRRLAARVAGQVHEAARRCLGPGQGELDRAAFEEVFPWRTGWASAVLTEGLLVPAGAGYRFAHEELGDWVQGAHLDLDAALRSLVHRWHRGSGAVVRLPSAGTEGEPRSLPVPRHRIGPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJH7</accession>
    <name>A0A7K2ZJH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="15100" checksum="4B6995AC0F59FAC7" modified="2021-04-07" version="1">MSTEATPSTPSPAATERPRRITALAGINALEGAALAVGGLYLLVMGVLGRPESPQQAETVGITLIALGAIPLIAARGLMLLRSWSRGPALITQIMALPVAWTLLRSQGALIPAGIVLAAVAVTGLVLVLNPATTQILGLRRGAGADPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKF8</accession>
    <name>A0A7K2ZKF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmD</name>
        <name evidence="7" type="ORF">GT040_26575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015610734.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001248.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6939" checksum="F27CEEFB21C96FEE" modified="2021-04-07" version="1">MARLKITQTKSYIGSKQNHRDTLRSLGLKRLNDSVVKEDRPEFRGMANTVRHLVTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKI1</accession>
    <name>A0A7K2ZKI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rdgB</name>
        <name evidence="8" type="ORF">GT040_26675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001249">
        <property type="protein sequence ID" value="MYW32759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="20855" checksum="5BA0BBD0C3A65E4F" modified="2021-04-07" version="1">MTRLILATRNAGKITELHAILADAGLDHDLVGADAYPDIPDVKETGVTFAENALLKAHALAQATGHPAIADDSGLCVDVLGGAPGIFSARWSGTHGDDQANLDLLLAQLGDIADAHRGAYFTCAAALALPDGTERVVEGRLNGTLRHAPSGDHGFGYDPILQPEGETRTCGELTPAEKNAISHRGKAFRALVPVVRELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKZ4</accession>
    <name>A0A7K2ZKZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_28070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001305">
        <property type="protein sequence ID" value="MYW33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="427" mass="43767" checksum="B9ABB687E66E2118" modified="2021-04-07" version="1" fragment="single">MTAPAAPRPDLAPQGHPQRWLILGVICLAQLTVLLDNTVLNVAIPSLTTELDASTADVQWMINAYSLVQSGLLLTAGSSADRYGRKKMLVVGLALFGIGSLAAGLAQSSGQLIAARAGMGVGGALLITTTLAVVVQIFDDSERVKAIGLWATVNSLGFAAGPLVGGVVLNHFWWGAIFLINIPVAVIGLVAVVRLVPEFKNPRGERPDLLGALLSTIGMTSVVFAIISGPEHGWTSGRVLLMAFVGVAVLAGFVRWELHIPHPMLDMHFFRNQKFIGAVAGAVLVAFGMGGSLFLLTQHLQFVLGYGPLEAGLRTAPMALTVVALNLTGLGARLVRRTGTPATIAAGMSALAAGLAAIAVLGRDGYTGMLLGLVVMGAGISLAMPAMANAIMSAIPPEKAGVGAGVNGTLAEFGNGLGVAVLGAVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL43</accession>
    <name>A0A7K2ZL43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001309">
        <property type="protein sequence ID" value="MYW33048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="32853" checksum="84383044E010AE59" modified="2021-04-07" version="1">MTNPAERLVDLLDLERIEVNIFRGRSPEESLQRVFGGQVAGQALVAAGRTTDGERPVHSLHAYFLRPGRPGVPIVYQVERVRDGRSFTTRRVTAVQEGRTIFNLTASFHRPEEAGFEHQLPPARIVPDPEELPTVAEEVREHLGALPEALERMARRQPFDIRYADRLRWTQDEIKDADPRSAVWMRAVGPLGDDPLVHTCALTYASDMTLLDAVRIPVEPLWGPRGFDMASLDHAMWFHRPFRADEWFLYDQESPIATGGRGLARGRIYDRSGQLLVSVVQEGLFRRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLA6</accession>
    <name>A0A7K2ZLA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001330">
        <property type="protein sequence ID" value="MYW33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="232" mass="24639" checksum="31E089A4CA30D684" modified="2021-04-07" version="1" fragment="single">GAAPGGGALRAAPAAFTGWIARLLLRACREHAAEMERCVAATASMRAQGVDYALRIAAQEQVGLAYAGWDRLLTRVALPAWRMGRWPSRLDAGVVSALTELSRRDRLADGFTSRLGERPACDLLEEPGIADEATSLLAARLFHGGPAESGPDWAPVDWQQYPDEVVDRKWRTEAARLHRVLDAMGVPPASVADPAVPTLARVMEHLAGPGGPREELAAGIGAAVARDDAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLG2</accession>
    <name>A0A7K2ZLG2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpmI</name>
        <name evidence="7" type="ORF">GT040_29000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001351">
        <property type="protein sequence ID" value="MYW33197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003970213.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001351.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZLG2"/>
    <dbReference type="GeneID" id="63978856"/>
    <dbReference type="GeneID" id="66957287"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6992" checksum="AE5797675E8BC7E4" modified="2021-04-07" version="1">MPKNKTHSGASKRFKITGSGKVLRERAGKRHLLEHKSSKKTRSLTGTVVVAPADAKKIKKLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM64</accession>
    <name>A0A7K2ZM64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="6">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sdhB</name>
        <name evidence="9" type="ORF">GT040_30345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="6">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001396">
        <property type="protein sequence ID" value="MYW33453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="29410" checksum="6EE721D57299F8A7" modified="2021-04-07" version="1">MATPTLDKTDGTAKPEAGFGDSPFITATFRIRRFNPEVSDEVQWQDFQIEIDPKERVLDALHKIKWELDGTLTFRRSCAHGICGSDAMRINGKNRLACKTLIKDINPEKPIMVEAIKGLTVLKDLVVDMDPFFQAYHDVMPFLITKGNEPTRERLQSPEDRERFDDTTKCILCAACTSSCPVFWNDGQYFGPAAIVNAHRFIFDSRDEAGEQRLEILNDRDGVWRCRTTFNCTDACPRGIEVTKAIQEVKRALITRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMI6</accession>
    <name>A0A7K2ZMI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001428">
        <property type="protein sequence ID" value="MYW33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="11994" checksum="1F6ED038D15951D3" modified="2021-04-07" version="1" fragment="single">MRAAAVAAAEERVAEAVREAEGVLAAARKEAEEVRGAAETAMAQTRSRTASVLSHQDQEHAERHQAAEAGIAAAEAESEARHKELTDRAEALLAEASRALAETREAARHGQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMQ0</accession>
    <name>A0A7K2ZMQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6774" checksum="4E9D4B760999660A" modified="2021-04-07" version="1">MIQPGQTCDPDGDVVVTKKGHPLYALTVSRDHMARYKLTEADVRATRDGAPRRTGYVLEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMU2</accession>
    <name>A0A7K2ZMU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_31225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="9596" checksum="080C0B6014C7FE38" modified="2021-04-07" version="1">MKKPQSLPVEQARKEFADLLDGSQHKGEHTEITRRSKRSGVLVPPDWYDAVTAEQAELRELRRENTELRRENAELRLAVDDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMZ4</accession>
    <name>A0A7K2ZMZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PQQ-binding-like beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001440">
        <property type="protein sequence ID" value="MYW33668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="486" mass="50753" checksum="758D25BAFC87212C" modified="2021-04-07" version="1">MQIIVAAAVAVVLIIGAAVVYTSTKDDGDQGNQASTSGSSGGGEGKGGEGKDGEGKDGGLAGGSEKAPGNTGSKVAFQLPQPEVADVTSVKGSWLTDKAYVKTGVNEIVAYDRDKGTKLWSLPVPAEVCGASRHITKDFKAAILFKEGKPTKEKKYPACNQVGAVDLASGKLLWSKSVTSATGGDRPVQFDEVTLSGSTVAAGGTSGGAAFKLDNGAELWKPKVSADRCYDMGYGGGEALAVVRKCGSYDSPQLQIQALNPATGAPLSSYQMPAGVDYASIVSTKPLVVAANVGDTANDGSGISDFFSIDAATGKLIVRISADAEKYAARCGSTDVESCRGAVVGNNRLYVPTEDHDGTSEYGDTNEVVAFDLTTGKLLGGRADAGDRYSLTPLRMDGTNVIAYKRPPYDKGGQVVSIDGETFKQTLLMENPSDESVRDAETAFTADRSEVLYAEGRLFFSKQLISERRDSQADEKLYLAVAFRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN93</accession>
    <name>A0A7K2ZN93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029774648" evidence="1">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19883" checksum="543F94ED4654E7C4" modified="2021-04-07" version="1">MPLAVLLLGITGSGKTTLAQALADHGYTRLSVDEEVHRLHGRYGVDYPEHTYFERQRPVVEAIRHRFAKELEAGNDIVLDYGLWLREERDAWQQAARDAGGHPVVVYLPASREELLKRLAERNMRDDANALTVTPEALDDFFARFDPPADDGHIIVYTGDLAVLMAALSTKRYRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNE6</accession>
    <name>A0A7K2ZNE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001489">
        <property type="protein sequence ID" value="MYW33876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="904" mass="99771" checksum="8325B1C0E9D41574" modified="2021-04-07" version="1" fragment="single">MAPRLTVVVPLYNVEEYLGACLTSLAEQTMADLEVVLVDDGSTDNGPSLAQEFVDRDPRFRLIRQENAGLGAARNTGVREADPKGEFLTFVDSDDVVPPGAYARMLAELDSSGSDFATGNVLRLRANGALEQSPMFRKPMEKARPATHVTRDWILLGDRIACNKVFRRTFWDEHAFAFPTGVLYEDIAVVLPAHFLARSVDVVEEPVYHWRDRDGSITTRRAVPKGIRDRVTAVTTVSRFLAGRDGMAEAKQRYDAHALSGDLWLFIEALPDGDEEFHTAFLDHAGAFASTVEPAVFAGLPLDLRVKWQLIRERRIAELLALLQEEKTDRDAFHVRGLLRPRAHLPALRDPLPPATTALAPADLPVHAHLTEAVWRDGLLRLTGYAYVRNVPGGPPPRLGWLRAGKRLIPLRLRPTGGPRGSGGSGGDEATARSGRSLHRYERAGFEAVVDPRAIATKSKNKSKSKGGRTTWKLEAALFGAGRVRRGPMRLTGTPAPPAPLYTDERNRVVPVLSGNKLELRTERVAAVLTGRSAVDDDTLRLEVQVLDDDGPVALRLTEWRTKETQEFALRGSLGSRAADVPLSAFRGQDEIWGVQLVGGKGRLTVAARTDAEAGRYPLPGVPGGREVYVAPNPSGDLVLTDRAVQPVVTSVQWAEGGELVLEGAFPEPSGTIGELVLRHGGHHEEATVDVELAESGHFRAVVRPTAVDGPAGPLPLAEGRWYLFLREPGERDPDAYRPLRLDTPLHTTLPLQQASLVRPFTLQRRYHDRLVLESGSALPVTEQGPYGQRIQRERYAALRAADRDQLRQAVLYSSFDGRQFSDSPRAIHRELASRKTDIEHLWVVRDQQAAVPEGVRAIALHSAEWYEALARSRWVVTNTHLPQWFERAEGQCVVQTWHGTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNF2</accession>
    <name>A0A7K2ZNF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_32660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001492">
        <property type="protein sequence ID" value="MYW33893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="55"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="3">
        <location>
            <begin position="306"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="458" mass="48094" checksum="C1005026ED17C884" modified="2021-04-07" version="1">MEAAITDSGRTTQTPTPPFARPAVRFDAAVRAAVGQGLLSESRPVAGFIDTDGVRSSVTELREAFAHSPRVLHTFAAKASSLIPVLRLLADCGMGCEVASPGELRLAVEAGFAPGTIVLDSPAKTREEIRLALALGVAVNADSIDELRRIDTLRHRGAPSVLGLRVNPQVGGGAIGPMSTATDTSKFGVALRDPVAREAVVRAFEARPWLTRLHAHVGSQGCPLELIAAGVAQMYELAEEINERLGTRQVTSLDIGGGLPVNFTDDSTHPTYAAYVDALTAAAPGLFSGRYALVTEFGRSLLAKNGFIGARVEYTKDAGGRRIALTHAGAQTATRTVFMPDSWPLRVGAFTEDGSPKGGRPLAQDVAGPCCFAGDVVAHGRELPELAEGDFVVLYDTGAYYFSTPWAYNSLPRPAVYGFRSTAPGGEVVFATVREAQTMDAIAAESGLAYADALTGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNL2</accession>
    <name>A0A7K2ZNL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001486">
        <property type="protein sequence ID" value="MYW33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molydop_binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="10668" checksum="C3E05D19E868387D" modified="2021-04-07" version="1">MLLDLGRLQEGDTALAGTRHAAVARLSATTAAETGVKDGDPLAVTGPAGTVELPLQVTDMPDRVVWVPLNSVGRGIPADTGANPGGLVRIGPAAAPGAPVEPSEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNR9</accession>
    <name>A0A7K2ZNR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Betaine/proline/choline family ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_33110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001507">
        <property type="protein sequence ID" value="MYW33982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514317.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001507.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="388" mass="42333" checksum="DBEC77A994E084FA" modified="2021-04-07" version="1">MIRFEHVTKRYADGTTAVDDLSFEVAEGELVTLVGPSGCGKTTTMKMVNRLIEPTEGTIFLDGEDISAVDPVELRRRIGYVIQQVGLFPHKTVLENTATVPHLLGWKRGKGRERAAELLDLVGLDPSVYGDRYPEQLSGGQRQRVGVARALAADPPVLLMDEPFGAVDPVVRERLQNEFLKLQAQVRKTVLFVTHDIEEAVRLGDRIAVYGSGRIEQFDSPATVLGAPATPYVADFVGADRGLKRLSVTPIEESDLDQPPVVHLDDSLAEATARLRSEGARWAVVLDGRDNLHGWIPAEAATAAKGTVREHARRMEAWLPLGAPLKQAFATMLQHDAGWIAVIDKESEGRFLGVLTPARLHEALRRSIDADAQAVPRAEVAVETVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNU5</accession>
    <name>A0A7K2ZNU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001535">
        <property type="protein sequence ID" value="MYW34026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7517" checksum="E31131AAFEED5294" modified="2021-04-07" version="1" fragment="single">VTEGLAPSVGPRPELDGLPCDFFYSVTDCDPRELLGVAAQRLMDRFAQLAVIAAREAVADAGLDPALWDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNV6</accession>
    <name>A0A7K2ZNV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3099 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001502">
        <property type="protein sequence ID" value="MYW33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="85" mass="9825" checksum="95CD0ADC85FDF069" modified="2021-04-07" version="1">MYARRRRGYFWMMGGCVALFVSAWAVVRLWSIPAAVAMCLVAMVIPPVAAVLANRRGPEDRWWDDPSGDPKSDEWWDELDGRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPS9</accession>
    <name>A0A7K2ZPS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001598">
        <property type="protein sequence ID" value="MYW34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6334" checksum="7E03546584C726B5" modified="2021-04-07" version="1">MDDASYCATPAPAPAGPEADAGPPFAECVLCREPTEYPESTRGATLCPVCAWQEAGRSACSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPX6</accession>
    <name>A0A7K2ZPX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_34855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001591">
        <property type="protein sequence ID" value="MYW34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="241" mass="24740" checksum="8C20A210AB27E47A" modified="2021-04-07" version="1">FYLMTIVLGFGAAAILKPGDIIASNKAGNTAAPLAALEIGGGSGSTGGAILLAVISAVAFATILAVVAGLTLASSSSFAHDIYANVIRKGKATEKEEVRAARWATVAIGIVSIALGALARDLNVAGLVALAFAVAASANLPTILYSLFWKRFTTQGALWSIYGGLSSSVLLVLFSPVVSSKPTSMFPSVDFAWFPLENPGLISIPLGFLLGWLGSVIGKEKPDTDKYAELEVKSLTGTGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ28</accession>
    <name>A0A7K2ZQ28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001603">
        <property type="protein sequence ID" value="MYW34369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7278" checksum="93DF6DCBF41D4A34" modified="2021-04-07" version="1">VIEVRAQDAPGLLHRIGNALEGCAVRVRSAHVSTLGANAVDAFYVTGTDGEPLPEIRAAEVARVVEKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ44</accession>
    <name>A0A7K2ZQ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001625">
        <property type="protein sequence ID" value="MYW34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="8"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="291" mass="30299" checksum="2E2EB636B08C492E" modified="2021-04-07" version="1">MNEYLRQALELVELGIPVLPLREGKGPFGNCDACAKNHCGGRPNMKSAGTCACPRPCHAWAAASNSVDVVTSAAWAAAWRQAGAVAYHPGGTGVTVVDLDNAHAVSWAHDALPATRTVATTRGEHWIYLGTMQSSNGVRPGVDIKSLMSYARWLGPGVGEMIRLPETVTALPRYVVPTGAVASSPMPRASWTRAVASGCRHTERYVRTGLDKGVAMVVGHREQGAASQAFGVARFLGSLHGECPGPCGLETLGGEIIAAAASVGVPESYAARAVDRGFAEAGAQVPTTQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQH6</accession>
    <name>A0A7K2ZQH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001641">
        <property type="protein sequence ID" value="MYW34575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="13033" checksum="B9BB838301966E3E" modified="2021-04-07" version="1">PVAGSGVSLLACTPGESHTLALEALAAGLGQQGLPVRMFGAALPMAAMEEAVRRTGPAAVVLWAQSRSTASRALVARVESIEWGVRGARRRPVVLVAGPGWAGQLPPGARHPSGLAEALDALAAISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQI4</accession>
    <name>A0A7K2ZQI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl-ACP synthase 3</fullName>
            <ecNumber evidence="4">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_36480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001659">
        <property type="protein sequence ID" value="MYW34631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="150"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="26590" checksum="2D3D507868FB05E1" modified="2021-04-07" version="1">ATAPALAARLGLGTVPALDIAAVCSGFVYGLALSHGLVASGLYERILLVGADVYSTWLDPDDRSAGVVFGDGAGAALVAAGRTGDPGELLAFDLGSDGTGNGLITVPGGGARTRADGKPPALSDAYFRMQGQTVYQHAVERMTGSCRVLLERVGWDPAEVDHFVPHQANARILRAVADRVGIASQRCVTHLERVGNTGAASIPLALADAAGRGLLQGGDRVLLTAFGGGLTWGSAALRWPGTPQTNSTISTEGTQHVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQJ1</accession>
    <name>A0A7K2ZQJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Presqualene diphosphate synthase HpnD</fullName>
            <ecNumber evidence="3">2.5.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hpnD</name>
        <name evidence="3" type="ORF">GT040_36260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.103" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001644">
        <property type="protein sequence ID" value="MYW34587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017828">
        <property type="entry name" value="SQ_synth_HpnD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03465">
        <property type="entry name" value="HpnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="313" mass="34397" checksum="617EC00AE995400F" modified="2021-04-07" version="1">MEGQTTYMSPPVQAAYSYCEAVTGQQARNFAYGIRLLPYEKRQAMSALYAFSRRVDDIGDGELDPGTKRTRLESTRELLDRIRHGKVEEDDTDPVAVALADAARRFPLPLEGLDELIDGVLMDVRGATYETWDDLKTYCRCVAGAIGRLSLGVFGTEPGAPGSERASEYADTLGLALQLTNILRDVREDAANGRTYLPADDLAKFGCSAGFHRTTPPPGSDFAGLIHFEVRRARALFAEGYRLLPMLDRRSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGHEKAYVAVRGLSGLDARHVSRLTSRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQL8</accession>
    <name>A0A7K2ZQL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001640">
        <property type="protein sequence ID" value="MYW34559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="20470" checksum="1A8CEFFC1415B16C" modified="2021-04-07" version="1" fragment="single">MPSLRASRPASPAAGMACGLRAGSLAVLCVSLPLAAHLLARCQAPVWAVVAAVAVVAVPAAVVLTRRRLSDNQVVGVLAVSQLAYHLVYALPGVCRAVGADGVPLWAEHAASTHVPSGVLLSGQLVALLVAARALGLTELLLGHGRPLLAAVGRLLAFVRPSACEPRAHGPRRGHRERTRRLRSAVLARLRSGRAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQP5</accession>
    <name>A0A7K2ZQP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001642">
        <property type="protein sequence ID" value="MYW34579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029744969" evidence="2">
        <location>
            <begin position="27"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="187" mass="19120" checksum="F8FB275D59D298AC" modified="2021-04-07" version="1">MSRTRVASLAVATASVPLLLAGCGIQETDPIEAGGPATVEAFYNRDDDMMLFFRTPDGGLNPVLRTVRPSAGFGGDYAESDPGSTPGPPSTEKTVLALLAGPREEDRAAGLTTALPPARPGTTVTVRTTPGGTVTTDLPFPLKALNTTARRQLTCTIAYSQAADGKAVVKLTGQDGASSSDTCGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQX0</accession>
    <name>A0A7K2ZQX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fasciclin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_37215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001686">
        <property type="protein sequence ID" value="MYW34770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029705907" evidence="2">
        <location>
            <begin position="35"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="82"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="21868" checksum="7F57546F2382B74F" modified="2021-04-07" version="1">MNALRHRRAAVAVVAAVMLPLSLAACSDSGSDKASDSSSAAGSTPEESKPAAGDDAMTDKPFGPACAGVPKDGAGSFDGMAKDPVATAASNNPALSTLVAAVQKAGLVDTLNNAENITVFAPTNDAFAKIPKADLDAVLNDKAKLTEILTYHVVGQKLTPQQLESGTFDTLQKSTLTTAGSGESYKVNDSANVVCGNVPTANATVYIIDTVLMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR04</accession>
    <name>A0A7K2ZR04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001690">
        <property type="protein sequence ID" value="MYW34804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="17895" checksum="682DAEAC7B345F83" modified="2021-04-07" version="1">MIIDIPEGQEPIGYVWGEMVPGIGMAAATFSMSVYEHTTLGLREFEAARLRIAQVNGCLFCLDWRTERDGAKVEEEFAQAVTEWRTTDAFDARTRLAAEYAERYALDHHGLDDAFWQRMTAHYSQVEIVELSMSIGSWLAFGRLNHVLGIDAVCVLPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRA7</accession>
    <name>A0A7K2ZRA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001697">
        <property type="protein sequence ID" value="MYW34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="17621" checksum="1073247326AF55FA" modified="2021-04-07" version="1">MLLALVTAAIAVVGTLLGSFISGRFQERAAERSVRVSHGETIRRDRLEAVTALACAASDHRRTMWMRGDALLKGAEAELIQSLRRESHQTRSQVTRPLVAMRVLITDPAVRTAADHMITLTYAIRDHFGSTEELTAAREAAMVAHDQFVDTAARYLAQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRC1</accession>
    <name>A0A7K2ZRC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_37870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001722">
        <property type="protein sequence ID" value="MYW34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22345" checksum="D01576FACD6645B5" modified="2021-04-07" version="1">MARVRLNVAERREEMLRATVEQIEIRGASSVRIADVASALGVSNALVLYHFSTKEKLVAAAFGYAAEADLAQLRKLLARRTSAVRRLRAAVRWYAPTGQAKGWRLWIEGWAVSLREPALREVAGDLDRRWKAELAEVIAEGAAAGEFRCEDPESAAWRLTALLDGLAVQMTSYAGPLSRSTMLRWTDDALARELGLDHAALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRG4</accession>
    <name>A0A7K2ZRG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_38265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001733">
        <property type="protein sequence ID" value="MYW34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="138"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="35796" checksum="40D2A644EC64393C" modified="2021-04-07" version="1">MLTTEEEPGTRADAPTPHPAPTKATPTPAPTPPQRAPGRLLALAALLSAALMALHVHLPNTALNLGSLFQTLLPWTGLAVPALLALAAVRRSRLAAIAVLAPALVWATLFGPTLTDKGNDGGKGTGATGHGLTVLSHNVDEANPDPAGTARALAGAKADVLALVELSEESTPVYERELATAYPHHAVLGGVGLWSRHRLTAVAEVEIMPWTRAMRATAATPEGPVAVYAAHLASVRVSGAGFTTARRNEAARALASAVRAEPAPRVVVLGDFNGTYQDRALAPVTSQLRSAQREAGDGFGFTYPAGFPVVRIDDILVRGMDPRASWTLPATGSDHRPVAATLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRG9</accession>
    <name>A0A7K2ZRG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001732">
        <property type="protein sequence ID" value="MYW34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="20466" checksum="48904B12907E38E7" modified="2021-04-07" version="1">MGVTLAKGGNVSLSKVAPNLTQVLVGLGWDARSTTGADFDLDASALLCRSGRVLGDEWFIFYNNLTSPDGSVEHTGDNLTGEGDGDDESVIVRLDQVPAHCDKIVFPVSIHDADNRGQAFGQVGNAFIRVVNQADGQELARYDLSEDASTETAMIFGELYRYQGEWKFRAVGQGYASGLRGIALDFGVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRM6</accession>
    <name>A0A7K2ZRM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001749">
        <property type="protein sequence ID" value="MYW35024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="247" mass="26736" checksum="FAB3D6EB36726983" modified="2021-04-07" version="1" fragment="single">MGVAGSFPSFAGRPPGPVMDREEADRALARLGAEHEAIETSLLALQDHAGRRLLEGAELTGLTRERWATTEQSITVLWGYFDAYAGALEEARDIRARRRHPNREDLAALTELLRGEAVTVANSGAVPPSSVTGPARLSERFSLQELVVRMNELYARSLDMVVASDSVWSALPARIDLLAAELHRTRSLAHSVGVRPGEHPAGDDLEEITEELTTLRVQVISDPLAFWLPGPGSAAPGGGRPDTSRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRN8</accession>
    <name>A0A7K2ZRN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_38200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001732">
        <property type="protein sequence ID" value="MYW34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="539" mass="55435" checksum="0B3AB7D5872B54A4" modified="2021-04-07" version="1">MTSQTTVEKAPREPEDRPAPAAAKGLRGHPWLTLFAVAIGVMMVALDGTIVAIANPAIQKDLGATLADVQWITNGYLLALAVALITAGKLGDRFGHRQTFLIGIAGFAASSAAIGFSKEIGLVVLFRVLQGLFGALLMPAALGLLRATFPAEKLNMAIGIWGMVIGASTAGGPIVGGLLVEHVSWQSVFFINVPVGIVALIFGLVILKDHRAANAPRSFDILGIVLLSGAMFSLIWGIIKAGESWGWGGAWTWFFLGLAIALFLAFGLWQTRVREPLVPLAMFRSIPLTAGAILMVLMAFAFMGGLFFVTFFLQGVHGLSPVDSGLHLLPLTAMMIVSSPVAGLLITKFGPRVPLVGGMVCTATAMFGMTTLSESTGTFAMSLWFALLGCGLAPVMVGATEVIVGNAPLELSGVAGGLQQAAMQVGGALGTAVLGAVMSSKVSSEFAGNWTDAGLPGTPDPKLEEAAEFGMVPVDALSKAPGMTPDVIDTIGGVIHDTFMSGMGLAFTVAGVVAVIAAGVATLTKRGANAEAGAGVGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRT8</accession>
    <name>A0A7K2ZRT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_38700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001763">
        <property type="protein sequence ID" value="MYW35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="7">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="320" mass="32379" checksum="5BC125C80DBA632D" modified="2021-04-07" version="1">MAEVLVLVDHVDGAVRKPTLELLTLARRIGDPVAVALGAGAEATASVLGEHGAVKVLTADAPEFGDYLVVPKVDALQAAFDAVGPVAVLVVSSAEGKEIAARLALRVGSGIITDATDLEAGEQGPVATQAAFAASYTTKSRVSKGVPVITVKPNSAPVEPAAAAGAVEALPVSFGETATGTKVTSRTPRESTGRPELTEAAIVVSGGRGVNGAENFPLIEALADSLGAAVGASRAAVDAGWYPHTSQVGQTGKSVSPQLYIASGISGAIQHRAGMQTSKTIVAVNKDAEAPIFDLVDYGVVGDLFTVVPQLTEEINTRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRV0</accession>
    <name>A0A7K2ZRV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001750">
        <property type="protein sequence ID" value="MYW35027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="293" mass="31701" checksum="7079C193E3D32AAB" modified="2021-04-07" version="1" fragment="single">MPQVVRTRIAVPHGAHPAAPLPRSFRSLADRAAVEVLHRAARVLVASLPVLTDRLVEALYAQEPGYRAAIDSDRAEVWQEVHHSLRHNVGSLIQPREFRDAAHRTSRWIGEIRAEQGVPLDAVLHAFRMGGAMVWQDLVDETARRDPDDVRLLVHVAADVWNFVDEHCGIVADAYRQAERRLSWRRENQQRLMVAALLDGTARIADIGEAAAMLGLPEQGRYAVLAVASAPGGPQQHDPAQPPLNLPAALSPGEGLSTAPGAAPLWHTGPDTAFAILRLAGGAGDPGDPGELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS81</accession>
    <name>A0A7K2ZS81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001816">
        <property type="protein sequence ID" value="MYW35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="10103" checksum="707257C61B3EA899" modified="2021-04-07" version="1">AQLRHGPASDDPGPSGALGDRAALVAALRELRPDQRRAVVLHHLLDLPVEEVARETGSTSGAVRTRLSRARRQLGERLADMDTYEDEGMARHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSE0</accession>
    <name>A0A7K2ZSE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxybenzoate octaprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_39840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW35263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="310" mass="32922" checksum="C62324CF09CC0439" modified="2021-04-07" version="1">MSSAAEAASVPGSAPSGSTSGSKVKSFLRLVMIEHSVFALPFAYIAALTAMFQLDGTIHWGVLLLVTLAMVGLRTFAMAANRIIDREIDARNPRTAGRELVTGAVSVRSAWTGALVALAVFLGAAALLNPLCLMLAPLAVVPMVVYPYGKRFTNFPHAILGLAQAIGPIGAWLAVTGSWSWDAVILGLAVGIWIGGFDLIFACQDVQADRAHGVLSFPARFGIPAALWGARVCHAVTTGLLVWFGLATGAEIFYWIGMVIVAVAFVYEHRVVRPHDLSRLNRAFFSVNGFIGMALFACALLDLLVRGLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSK5</accession>
    <name>A0A7K2ZSK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_40435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001839">
        <property type="protein sequence ID" value="MYW35374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Germane" evidence="3">
        <location>
            <begin position="69"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="17619" checksum="9E9D1E4A4AFCBCE2" modified="2021-04-07" version="1">MRVQRGAVVLAVLGVLGALLAGCGVGVRPTGVIDAGEPASGLTRGARLYFASGSGLRAVPLIDRDVSDLDAVMKLLSQGPSSAEQREGLTTLIQGVSGYAVTGDGPRVTVRLEGPYWAAERDQATGQLVCTLASFQSVREAEVRADDVEVTVRPGEGPTLGPLRCAEFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Y8</accession>
    <name>A0A7K2Z5Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_00335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000008">
        <property type="protein sequence ID" value="MYW27757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="168"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW27757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="414" mass="43921" checksum="EE116B210C7CCC08" modified="2021-04-07" version="1">MARSQEQETEPQTATATPPPQPGRGTLGVGMVGYAFMGAAHSQGWRTAGHVFDLPVRPALAAICGRDRAAVDAAAARHGWAAAETDWRALIARDDVQLIDICTPGDSHAEIAIAALEAGKHVLCEKPLANTVAEAEAMVRAAEAAQARGQVAIVGFNYRKVPAITFARQLIADGRLGTLRHVRASYLQDWLVDPASPLTWRLKREHAGSGALGDLGAHIVDLAQYLAGELLTGVSAVSETFVRERPLLSGASAGLLGGADAVARGEVTVDDAAIFTGRLASGALASFEATRMAAGRKNALRLEINGELGSLAFDLERLNELSFHDHTEPAATAGFRRILVTEPEHPYLEAWWPPGHALGYEHTFVHQARDVVRTIAEGLPPRPSFADGLQVQRVLAAVEESAAKNSVHTPVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z643</accession>
    <name>A0A7K2Z643_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000012">
        <property type="protein sequence ID" value="MYW27773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="20561" checksum="381653EFFE3B6B45" modified="2021-04-07" version="1">MDSLGDSLDRALEGAFTRRIPQSAQAQMKYLVKQLKGTKAAAQALGISQRTVERYASGKLKRPRQDLRGRLEREVKKRWQPQIRAKARKQAASTGGLVVSTRARFGFEAAGGTTDDARIRDITQALPPEYADKLFTAREQGKTEDQLRQIAADGLARMYFRANNSRAHGLGVEFTDVERLDIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z663</accession>
    <name>A0A7K2Z663_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_00735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000022">
        <property type="protein sequence ID" value="MYW27831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="442" mass="47365" checksum="AE98B3BCA9EB5227" modified="2021-04-07" version="1">ARAAFDDGPWPGTPAAERGRLLLRVAELLERDKGIFARAESLDTGKRLVESAYDMDDIANCFRYFGNLVAAGDGGRVVDTGIADVDSRIVHEPVGVCALITPWNYPLLQTAWKVAPALGAGNTFVLKPSELTPHTAVLLMGLLVEAELPEGVANLVLGAGAAVGAPLTEDPRVDMVSFTGGLTTGRAIMAAAAPTVKKVALELGGKNPNIVFADADFETAVDYGLMAVFLHSGQVCSAGARLLVQDELHDRFVDELVARARRIRLGGPFDEDARSGPLISAAHRDKVEAYVAEGIAEGAVLRCGGARPDDPALADGFYYPPTVLDECTSSMSVVRDESFGPVLTVERFRDEDEAVRLANDTVYGLAGAVWTQDGGRAHRVASRLRAGTVWINDFHPYVPQAEWGGMKQSGFGRELGPAGLAEYQEAKHIWRNVAATPQRWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z675</accession>
    <name>A0A7K2Z675_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">GT040_00760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="WWKE01000024">
        <property type="protein sequence ID" value="MYW27836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW27836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="310" mass="32778" checksum="4F26304185A0DE47" modified="2021-04-07" version="1">MKLVFAGTPEVAVPALDALIASDRHEVAAVVTRPDAPAGRGRRLVASPVAERAAEAGIEVLKPARPRDEEFLARLREIAPDCCPVVAYGALLPKVALDVPARGWVNLHFSLLPAWRGAAPVQHSVMAGDEVTGASTFLIEEGLDSGPVYGVLTEEIRPTDTSGDLLTRLAFAGAGLLAATMDGIEDGTLHAVPQPHDGVTLAPKITVEDAQITWSAPALRVDRVVRGCTPAPGAWTLFRGERLKLIQATPVLDRTDLAPGELSAAKNNVYVGTGSHAVELLWVQPQGKKPMKAADWARGVRIVHGELLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z682</accession>
    <name>A0A7K2Z682_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_00855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000033">
        <property type="protein sequence ID" value="MYW27855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW27855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="434" mass="48852" checksum="C5830CDA16A0321D" modified="2021-04-07" version="1">RPLAATFYEQRPAFHWHPGLLLDGASLQVPFLADLVTLADPSSPWSFLNYLRTRDRLFPFYFAERFHIQRAEYDAYCRWVTEQLPGLHFGHQVDAVRWNTERALFEVDFTQLDPDGEAEALGRAYARHIALGIGTEPFVPEPLRPLAEAPSVPVLHSADYLRHREQLLAADHITVIGSGQSGAEVFLDLLRARPEGAEKLHWLARTQAFAPMEYSKLGLEHFTPDYSRYFHALPETARDELVPRQWQLHKGIDADTIAAIHDELYRRTLHGGWPDATLTPGVHVRTAGRLANTRVELHLEHTQQGTRSRLTTDAVILATGYRERPLDALLGGLDPYLRRDTSNRPRIDDQYRLILDRAVTGHVYVQNAERHTHGVGAPDLGLAAWRSATILNNLTGTTPYPLPERTAFTTFGLTTGHPRVPAQAPALIPLSQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6B5</accession>
    <name>A0A7K2Z6B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zf-HC2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000052">
        <property type="protein sequence ID" value="MYW27889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="65" mass="7109" checksum="E1A8C748A449E01E" modified="2021-04-07" version="1">MSADPGDDPHVRLLLGAYVLDALDAQETCRVARHLQLCDACARDYVEVAEASALLALLRAEDLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6J1</accession>
    <name>A0A7K2Z6J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_01240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000057">
        <property type="protein sequence ID" value="MYW27932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="987" mass="105410" checksum="B3A83FD2B4F4ED5D" modified="2021-04-07" version="1">MDRDHGPRVRVPEQRAPEEPGAADSLRFTVLGPVRAWRGAEALPSGSPQQRALLAALLLREGRTATANELIDAFWGEDPPSQAKATIRTYASRLRKILGQETLVSESGGYALRIGRGALDLTLAQDLAAEAEKARASGDRCQARTLISKVLGLWDGEALASVPGPYAENQRTRLEEWRLQLTEARLDLDLEVGSHAEAVSELTALTAAHPLRERLRELLMVALYRSGRQAEALAVYADTRRLLAEELGVDPRPELAQLQQRILRADEELARPADEPAPAAAPVKPAQLPATVPDFTGRDSFVRDLGAQLATAEGSVMAVSALAGIGGVGKTTLAVHVAHQARPHFPDGQLYVDLQGAGARAAEPETVLGSFLRALGTADSAIPDTLDERAALYRSTLDGRRVLVLLDNAHDAAQIRPLLPGTPGCAALVTSRVRMVDLAGAHLVDLDVMAPDEALQLFTRIVGAERVGAEREAALDVVAACGFLPLAIRIAASRLAARRTWTVSVLAGKLADERRRLDELQAGDLAVKATFELGYGQLEPAQARAFRLLGLADGPDISLAAAAALLNLEPHTAEDLLEALVDTSLLESAAPGRYRYHDLVRLYARACAERDEQPPVERELALSRLLDFYLATAAGVYALERPGERVLDHFTRTAYPGLVFPHRDTALDWLFTESSGLLACARQSAAIGMPKRASDLLMAVVDLGESGANSHQFATAAKAVSDAARAAGEAQAEARARTMLSHVHSVSGRFAEADAEASRALALGQRAEDPVSLGQAPNQRGIIALYENRHEDAEAHLTQAMAAFRADGNKPGEAAALCNLSRVHLATGRTTSAVHLAQQGVAIYEGDATDLALRLANGKYALGLALIGSGQMPRARDALLAALQIFRESRQQLWHGMTLFRLAELHLAEQDGAQAAAHAEQALAVLRGIGGDWRRAGVLAVLGRGLTAIGQRDRAQVCWSEALAIFEELRSPEAASVRALLNPAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Y4</accession>
    <name>A0A7K2Z6Y4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000101">
        <property type="protein sequence ID" value="MYW28109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="10775" checksum="F297908305FB40A0" modified="2021-04-07" version="1">MATNDGTTVVTYASLDLAAASIDRQAKQLDQDLRAIKTMIASVSELWEGEAKTAYRAAQGRWDTQATGIKENLAQISRAVRDAETAYRSGDKRAAANFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Y5</accession>
    <name>A0A7K2Z6Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family 16 glycosylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_01985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000089">
        <property type="protein sequence ID" value="MYW28073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029715833" evidence="1">
        <location>
            <begin position="32"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="34"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="292"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="36277" checksum="CE75190F60882A2F" modified="2021-04-07" version="1" fragment="single">MRTPWRHRSLTWLAAAACLSLAALSPTAVQAAPAPDSGTVAPAAITFDENFDGPAGSGVNTSRWQLETGDNVNNHERQFYTSGTNNAALDGQGNLVITAKRENPANYNCWYGRCEYTSARLNTAGKFTAQYGRVEARMKLPRGQGIWPAFWMLGNDFGNVGWPASGEIDIMENVGFEPGTVHGTLHGPGYSGSGGIGAGYTLPGGAAFADAFHTFAIDWSPNSIRWSVNGNVYQTRTPADLGGRQWVFNKPFFLILNLAVGGYWPGDPDSSTRFPQQLIVDYVRVSTDTTTPPPGARTIRGIGGKCLDVAGASSANGTAVQLYDCNGTGAQQWDVRSDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z796</accession>
    <name>A0A7K2Z796_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000116">
        <property type="protein sequence ID" value="MYW28214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="6329" checksum="BC4BFC13BB54377B" modified="2021-04-07" version="1">MLDLAELSGLTGLLLLHRTDEMELLNAAGLYRAPGWDSCPLALADVDTADAYGLLIKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7G2</accession>
    <name>A0A7K2Z7G2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_03020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000143">
        <property type="protein sequence ID" value="MYW28271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="535" mass="57796" checksum="373FC628924330C7" modified="2021-04-07" version="1">MTTTANATDDSFHVFDTTLRDGAQREGINLTVADKLTIARHLDTFGVGYIEGGWPGANPRDTEFFARAQQEIAFENAQLVAFGATRRAGGSAAEDPQVQALLNSGAPVITLVAKAHDRHVELALRTTLDENLEMVRDTVSHLREQGRRVFVDCEHFFDGYRANAEYAKSVVRTAYEAGAEVVILCDTNGGMLPAQVQAVVSTVIADTGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVGNANLFPVVAALELKYGMKVLPEGALAEMTRISHAIAEVVNLTPSTHQPYVGVSAFAHKAGLHASAIKVDPDLYQHIDPELVGNTMRMLVSDMAGRASIELKGKELGVDLGDDRALVGRVVERVKERELQGYTYEAADASFELLLRGEVEGRARRYFRTESWRAIVEDRPDGTHANEATVKLWAKGERIVATAEGNGPVNALDRALRVALERIYPQLAKLELVDYKVRILEGRTGTESTTRVLITTGDGDADWATVGVAENVIAASWQALEDAYTYGLLRAGVEPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7W0</accession>
    <name>A0A7K2Z7W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000151">
        <property type="protein sequence ID" value="MYW28388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113265" checksum="457E0011B21406A2" modified="2021-04-07" version="1">FAQVRLQNLLAPKQESHLAAQLLDLESADHDLRFHRRLEQVRDMVAQLNARVSEKTDQLRAQLAGLNLGEADLARISGLIDRGDVATAEELLSFARKGESIPEQAAETGAEMAAFLEGVRHLGAPKPSSTGVSARWWFDHYAEGRFGQAETDAVTVALEAWDSLGRPNERRNSFQKHVPSVLRMLGLSVKGPVRLGDQDRKDWQVMTLSITAEISDNVPGYVSRLGSRAGGVYRVLVVANPELGPDALLRHLPEAALGANIILYLQPLGISGRRRLAQASYQKPQQAIVVDPAVLGWIAAGEVRSFRAVQRVTLPWAAYRPYEPFQAGQVSAEVFKGRDDEKSAIMAREGGLFLYGGRQLGKSSLLRQVADSFQAGHGGNQVAVYTDLRIVEIGLSRLPGEIWNVLAQELKAVGVLDHSTSGNVGPATVAAQVRQWLDENPERRILFLADEADAFLNADARPVDTAGAQSTFRTLASLMQLMADTERRFKIVFAGLHQVQRYNRLTNSITGHGGEPVLVGPLRPKAAVDLVVEPLAAVGLVFDNPDLVWHILALINNQANLVQIVCEGLVEEMQSRALSPDGGRPRITAADVQKVVASGGIRDKIRDRLRLTIDLEDRYRVLTLILALRSLTDGYARGYTPQELQEQAHGVWPEGFPEQNGVDEVRTDLMEMEGLGLVLPLQGRSNSFVMRSPNIVNMLGTRDELDAELRTSEFTQKYDYNPRVARRSIGVDARQIMRMSPLTDEQWHDALSRRITMITATTALGAEFLGKAARQHAGEHRQFVAVQAAELARTITKWARERTPHLLFVDLRGLPAAEVRDAVERLSKYAAASEEDGKEIPRRRTLAVVDPLTVPGLDLPEVFRVQPRRWNTTSLRAWPEQPFVSAQERRNLIEATGGWPAIVEQAIAQYLRGAPREDLFEAMRVRMDDPGPAVDHLRRVGLSDRHVRQMAAWADMFSLEEHRQGKAHAVPQDLAVVLDDDLDEAEALLTDLEALGVLDDGNEVLTVDSVTFRALRAVAGLQDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z806</accession>
    <name>A0A7K2Z806_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000179">
        <property type="protein sequence ID" value="MYW28471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="6679" checksum="9B287B2AD30FD2AB" modified="2021-04-07" version="1" fragment="single">MTLLLPALQSPTGPAASREAVRFGVLSLTYGELAAASTALAARIADAGRVAVWATPTAETVIAVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8D7</accession>
    <name>A0A7K2Z8D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">QacE family quaternary ammonium compound efflux SMR transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_04860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000213">
        <property type="protein sequence ID" value="MYW28614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510081.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000213.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="11067" checksum="7F05282352C3F4C5" modified="2021-04-07" version="1">MAWLLVVVAGLLETGFAVCLKLSHGFTRIWPTIAFAAFALSSFGLLTMALKKLDVGPAYAVWTGIGAAGTAIYGMVFLGDVVSTLKLVSISLVIIGVIGLQLSGSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8K2</accession>
    <name>A0A7K2Z8K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Topoisomerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000215">
        <property type="protein sequence ID" value="MYW28625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045970">
        <property type="entry name" value="DUF5926"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19348">
        <property type="entry name" value="DUF5926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5926" evidence="1">
        <location>
            <begin position="56"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="28437" checksum="5C510BA197C8E808" modified="2021-04-07" version="1" fragment="single">MAKKRPQTKAGKQQLKDGEIPVVGAREPCPCGSGRRYKACHGRAAAQAVTELVHRPFEGLAGECDWVALRELVPAATVELTLKGGLPEGVPSVTLATVLPMAWPALRRDDGSVLLALQNDTSSGDLSRDLADTLQRALEVEPGTPVTARRVPADGPRLQDLLDPDAAFEPVVRTGFEFWVPDAENATPEVAASLERANAAAIPTVLLSGADAAYWCETPEKNHLRWVMPHPEEQLLDALARLHAAGTSSLGEDTRLVGSFRAHGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8U2</accession>
    <name>A0A7K2Z8U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance/dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16070" checksum="89188C1F1AF90F9C" modified="2021-04-07" version="1">MSRAQLALNVADLEASVAFYSKLFGVEPAKRRPGYANFAITTPPLKLVLVEGEPGQETRLDHLGVEVDSTDEVAAATVRLKDAGLATFEENDTSCCYALQDKVWVHGPGREPWEVYVVKADADRMGKSAALEGEGCCAGQGGTAEVEAPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8X7</accession>
    <name>A0A7K2Z8X7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular small neutral protease</fullName>
            <ecNumber evidence="5">3.4.24.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Snapalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_05820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000255">
        <property type="protein sequence ID" value="MYW28801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029915537" description="Extracellular small neutral protease" evidence="8">
        <location>
            <begin position="27"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="193" mass="19580" checksum="F77B7C3CE548A716" modified="2021-04-07" version="1">MLNSIVLKAAGIAAAITLTTVTAASATQAPAPHVTEGAAAVVTLRYDDSRAGGWEAAIAAGVASWNSNVDNVKLVEAAPGVRAEIQIVATGGWPQAILGPVRPGGQVRVELGSQAVTEGHDKTRIAAHEIGHSLGLPDTKPGPCSQLMSGSSAGISCRNSVPNATERSRVESFYANGLASRTPADGRILVDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Y2</accession>
    <name>A0A7K2Z8Y2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsS</name>
        <name evidence="8" type="ORF">GT040_05725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000252">
        <property type="protein sequence ID" value="MYW28782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966956.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000252.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2Z8Y2"/>
    <dbReference type="GeneID" id="63982128"/>
    <dbReference type="GeneID" id="66955244"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="10511" checksum="C1C7DE45BDD89185" modified="2021-04-07" version="1">MPRSLKKGPFVDGHLIKKVDVQNEAGTKNVIKTWSRRSMIVPAMLGHTIAVHNGKIHVPVFVTESMVGHKLGEFSPTRTFRGHVKDDRKSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Z3</accession>
    <name>A0A7K2Z8Z3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_05640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="328"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW28765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="447" mass="48087" checksum="B47AF7493E2A4194" modified="2021-04-07" version="1">MALRITVIGTGYLGATHAAAMAELGFEVLGLDVVPEKIELLSTGRVPMYEPGLEEMLQRHVAGIEGSTGRLRFTTSWEEVGEFGDVHFVCVNTPQKHGEYACDMSYVDSAFESLAPHLTRPALVVGKSTVPVGSATRLAARLAELAPAGDGAELAWNPEFLREGFAVNDTLHPDRIVVGVESERAEKLLREVYAGPVAEGSPFVVTDFPTAELVKTSANSFLATKISFINAMAEVCEAADGDVVKLAEAIGHDERIGKKFLRAGIGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRRRGHMVELAREAVGGGSFLGTRVGVLGAAFKPDSDDVRDSPALNVAGQIHLQGGQVTVFDPKGMENARRLFPTLGYADSALEAVRGADVVLHLTEWREFRELDPAELGEAVSRRIILDGRNALDSAVWREAGWTYRAMGRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9T6</accession>
    <name>A0A7K2Z9T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AzlD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000353">
        <property type="protein sequence ID" value="MYW29117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="46" mass="4953" checksum="14323AEDBD2EDDAD" modified="2021-04-07" version="1" fragment="single">MNIWIAIGLTAVGCYLAKYAGLLVPAGVLERQIVRRMATLLPVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA23</accession>
    <name>A0A7K2ZA23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-dehydro-2-deoxygluconokinase</fullName>
            <ecNumber evidence="2">2.7.1.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolC</name>
        <name evidence="2" type="ORF">GT040_07830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.92" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000360">
        <property type="protein sequence ID" value="MYW29189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047590">
        <property type="term" value="F:5-dehydro-2-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030830">
        <property type="entry name" value="Myo_inos_IolC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04382">
        <property type="entry name" value="myo_inos_iolC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="29598" checksum="359F44A6F565CEA1" modified="2021-04-07" version="1" fragment="single">MPEPYDVITMGRIGVDLYPLDIGVPLARVETFGKFLGGSPTNVAVAAARLGRRTAVITRTGRDAFGEYLHQELQGFGVDDRWVTEVEEYPTPVTFCEIFPPDDFPLHFYRQPKAPDLEIHPPELDLDGVRDARIFWMTGTGLSAEPSRAATLSALQARSESPAREFRTATVFDLDWRPMFWDGGDHSAVAPARYREALAHATVAVGNIDECEVATGEREPHAAARALLAAGVELAVVKQGPKGVLAVHRDGSTADVPPLPVEVVNGLGAGDAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA73</accession>
    <name>A0A7K2ZA73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000373">
        <property type="protein sequence ID" value="MYW29250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="50" mass="5625" checksum="F84C4A19CFB1D629" modified="2021-04-07" version="1">MLRDACQRLAGTDARFATARFTAHDFRRLFATELVNNGVPFISAPRSWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAD2</accession>
    <name>A0A7K2ZAD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AfsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000386">
        <property type="protein sequence ID" value="MYW29306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="291" mass="30545" checksum="43C1BE0A38F67A0B" modified="2021-04-07" version="1" fragment="single">GGRPLTVLVSGAPGIGKSALAQHVAHLVRDSFPAGRLLVRMTRADGHPRTADEVAAEVAAALGPGRAGERALLVLDDVVDADQVRPLLTPPDLAVVVTSRMGLGGLIATHGGWVHRLTAFTEAESYALLLAALGTERVEAEPRAARRLTSLCGHFPVALRILTARLLTRPGLRLGDAVDWLGDDPLARLTLTDSPDHSVSGLFDRALGRLDPRLSEALLRIGAGPPALLGGADIADGPDGAAGPEGRKDHPPVPEDVLEQLADAGLLEDGPPGPYRIHDLLRAHLRRTVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAG1</accession>
    <name>A0A7K2ZAG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000396">
        <property type="protein sequence ID" value="MYW29318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="11383" checksum="9A4521919F7FAC24" modified="2021-04-07" version="1" fragment="single">DAGALVVDAAFRNPGRARAAGVRHALARAEAAAPVTWIATTDADSVVPHDWLAHQLARAREGWQAVVGTVVLPSTSPLAVPHRIRYEATRPPTGTPWAHPHVHGANLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAL2</accession>
    <name>A0A7K2ZAL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000404">
        <property type="protein sequence ID" value="MYW29368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="18"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="564" mass="63138" checksum="AE22AD56BBEA46B4" modified="2021-04-07" version="1">MRLTRTSDLWWKNAVVYCLDVETYQDGNGDGTGDFAGLTQRIDHLVRLGVTCVWLMPFYPTRERDDGYDITDFYAVDPRLGTLGDFTEFVRTARDRGIRVIADLVVNHTSDHHPWFQDARSSRTSAHRDWYVWVDSPPEDGPEGVVFPDAEHSVWELDETTGQYYLHRFFKQQPDLNIANPAVRDEIARIMGFWTQLGLSGFRVDAVPFLLETDGQQDADRLPDPHEYLADLRAFLGRRNGEAILLGEVNLPYPDTATFFGEPESGRGDELTMCFDFIGMQRMYLSMARGEAGPLAAALRERPAAPRDAHWATFVRNHDELTLDKLDDDERAEVFAAFGPDEDMQLYGRGLRRRLPPMVEGDRRRVELAYSLLFTLPGTPVLFYGEEIGMGENLAAEGRQAVRTPMQWTADKGGGFSGADAGALPNPVVEGAFGPKRVNVHDQAHDADSLLGRMRTLIERYRETPELAWGTYEVLDADDPGVLAHISSLPEGAVLVVHNFSDRAVRAATTVPGLKGGRLLTDVFTGSTVKSAAGGLVRTELEPYGYRWLRVNTPLDDPERVTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB48</accession>
    <name>A0A7K2ZB48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000452">
        <property type="protein sequence ID" value="MYW29554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="2">
        <location>
            <begin position="118"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="407" mass="43074" checksum="812D5C558C32071D" modified="2021-04-07" version="1">MTNSTTSAMDDTTAPGIPEQAAAPGREHRQITPPEDRYATELAFLAAHDTGPRPPGWRLTPRAVVTFVTGSAGEALSLPKGARPGADVPPRLVIEQKFVGERALVERCVVTLAGERGLLLVGEPGTAKSMLSELLSAAVCGTSALTVQGTAGTTEDQLKYGWNYALLLAQGPTEQALVPSPVLTAMTRGAVARVEEVTRCLPEVQDALVSLLSERRIAVPELAGSEGAQVHAAPGFALIATANLRDRGVSEMSAALKRRFNFETVGPIGDVDAETALVRSQSRAAVERAGAAYQVDDAVLEALVTAFRDLREGRSTEGWEVERPSTVMSTAEAVSVAGSLGLAAAYFPGDRDVLSLLPGHLLGVVRKDDPADAARLLGYWDGPVRRRAEQGSATWRALWDLRAVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBJ1</accession>
    <name>A0A7K2ZBJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000486">
        <property type="protein sequence ID" value="MYW29699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="257" mass="25377" checksum="54BE7EE607ABBA43" modified="2021-04-07" version="1" fragment="single">GARLDLAGALLATAGTTLLVLGLVRASDDGWGSAVTLSTLGAAVLLLTAFVAVELRTASPLLRPGLLRGRPVLTANLFCLLLASAQFGAFYFVSLYMQLVLGYGPTAAGFAFLPFCVGVVAGAILATRAVAVLGIRRLMSVGGTLAALGMGWFAATATVDGSFLASILGPSLLCSLGIGLCFVPLGTAATTDVVPGETGMASGLLNSSRQVGGSLGLAVLVTVAAQVTGGGTGTRDLSAGYAAAFWVAAGLLAAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBP5</accession>
    <name>A0A7K2ZBP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glsA</name>
        <name evidence="7" type="ORF">GT040_10905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="WWKE01000495">
        <property type="protein sequence ID" value="MYW29776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="332"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="427" mass="45092" checksum="884B513570A77E7D" modified="2021-04-07" version="1">MRPIIPDYLAEVLGQVEPDASGEPASYIPELAAADPERLGAAFATVDGQVHGAGDIDVPFTIQSISKPFAYALALADRGFGPVLAKVGVEPSGEAFNEISLESGTGRPLNPMINAGAITVHSLVAQAGSGPAERVRRVLDGLSAFAGRRLEMDERVCASEMEHAHRNLAIAHMLRSHDILTEDAGAVVDGYTRQCSVLVTTRDLAMMAATLANRGVNPLSGEQVVPEGVVRQVLSVMFSCGMYDAAGDWTTQVGIPAKSGVAGGLIGALPGRIGIATFSPRLDSHGNSVRGVSLFERFSSDMGLHVMEVPSAGRAVVRSSHVLGSGPDALRVLELQGGIGFAGAERVVREVLDTDPQETRVAIDLTRVHTIDDVARRMVLEIARRLTLDGRQVYLVDPEVVVPDPEPGDGGRVTVIREVRQAVLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBR6</accession>
    <name>A0A7K2ZBR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000496">
        <property type="protein sequence ID" value="MYW29784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="25785" checksum="95B1C49170B6AF20" modified="2021-04-07" version="1">MLDTNRRPGWSPARVNASHFCSVSSRSQPIPTRVVLLAGPSGSGKSVLAARTGLPVLRLDDFYKEQDDPTLPRVPGSTDIDWDSAASWDADAAVAAIAELCRSGRTDVPVYDIATSSRTDHETFHIERSPLFVAEGIFAADIVGRCQELGLLADALCLRGRPSTTFRRRLVRDLREGRKSVPFLLRRGWRLMRAERRIVARQTALGAYPCGKEEALGRFAAAAAGRCRRATVGAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBU7</accession>
    <name>A0A7K2ZBU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000501">
        <property type="protein sequence ID" value="MYW29809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="10114" checksum="FFB31EE592518C7E" modified="2021-04-07" version="1" fragment="single">MSTAILTGTPVPGSSLADDLRALGFDVVSAADAGDAAALLTDVPAEHRVALVDPRFLGHLHALRLGLTDPRFPAATVPGALTVQPQARPALLRALERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC29</accession>
    <name>A0A7K2ZC29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_11575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000533">
        <property type="protein sequence ID" value="MYW29904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="22047" checksum="59D09C9BB00D1311" modified="2021-04-07" version="1" fragment="single">STPWPGRLERAALRGGAGGRNADRDLDAVCALFETAARAEERTGGRGALNFLEEVDAQDIAADTLSRRTARPDAVRLMTAHRSKGLEWRLVVVAGVQEGLWPDLRRRGSLLEADRIGRDGLAEPLTPGALLAEERRLFYVAATRARERLVVTAVKAPADDGDQPSRFLTELGVEPRDVTGRPRRPLAVAALVAELRATTVDPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCB4</accession>
    <name>A0A7K2ZCB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000547">
        <property type="protein sequence ID" value="MYW29952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029831292" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8093" checksum="970C12DCB82786DF" modified="2021-04-07" version="1">MKKIMIAALPVLALSLAAPVAHADNDSNFGGGVNAANNWNFTAASVCLQEVAVVPVTGDYVSDHVNNCSNGNVIDHSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCD0</accession>
    <name>A0A7K2ZCD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000561">
        <property type="protein sequence ID" value="MYW30031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="127"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="29926" checksum="D7DD5232F99238D8" modified="2021-04-07" version="1">MASPVLRSVHLYPVKSLGAQTSDEIAVEPWGLDGDRRWMLVDKAPRVITQRQQPFLARISAVPLSGGGIALSAPGRPPLRVEVPGPERLVDVELHRDTVTVAEASDEAHTWFSEILGSETRLVHLDDPARRRAVDPAFARPGDMVSFADGYPLLLTTTASLDALNALIAEGDRPHEGPLPMDRFRPNLVVGSTEAWVEDGWRRIAIGDVPFSVVKPCGRCVITTTDQRTAERGKEPLLTLARHRRVGNQLLFGQNLIPDGTGVIRVGDPVKILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCE7</accession>
    <name>A0A7K2ZCE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">GT040_12220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000560">
        <property type="protein sequence ID" value="MYW30026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="23292" checksum="3433317268702EB8" modified="2021-04-07" version="1">MIRPDARYVLPEFTERTAAGTRTQDPYSKLLSERIVFLGSPIDDTAASDLIAQFMYLEHAEPERPLSLYINCPGGSFGAMAAVYDTMRFLTCEVETFCLGQAGSYAAALLAAGTPGRRHALPGARVVIQQPALAEPLRGQPSDLEIHARELVRTRELFTDMLVRHTGRTAERVTADIERDTILDAEAARAYGLVDHVVENRTLSQPPHDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCQ4</accession>
    <name>A0A7K2ZCQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="407" mass="43784" checksum="4C4DAD9F88C40FB6" modified="2021-04-07" version="1">MPPKPSNTRLKSARLAAGYHSQQALADALKVGVRQVRRWESEAPPWPHPDLQQALTRVLGQDLEALGFTPPAGHDPVRRTIIAGTAAAVGLAAVPSQAAAIIQPASVAADYEAVTRSHRRLYWSVAPATLHPAAVAHATLGCALLPESAGRTRQAVAAALAETWLLAGRIEFFDLREADRASTTWHRALQAAGEADDSLLGAAILAHTAFIPAWVGRRDNAVERMTAARTYARRGPASAQLLAWLDAVEAECETRCGNTQTALHLLGHGEDVLAAGSEHESPAWLDWFSPVRLAAFKGNTQLKAGHLPQARATLQGVLDSLPASEEKQRSVILGDLAAVEVAAGNPDTACRYACEALDQLEATWYATGMDRVREVRRALVPHQHQQCVRDLDERLYGWSTTVSALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCX7</accession>
    <name>A0A7K2ZCX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000607">
        <property type="protein sequence ID" value="MYW30193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="11829" checksum="5C3A831B1982A468" modified="2021-04-07" version="1">MLQRAAAQAGITGVPVTAVPPKGTRKGTQKGAQRSTQTGAPRPVQRAADDTSGFAPTSETPTENAASTTSRISGAEIEELARRLLDPVSRLIRADMRRGRERAGRLHDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDL5</accession>
    <name>A0A7K2ZDL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="26836" checksum="86B8E87FA2BA7DA3" modified="2021-04-07" version="1" fragment="single">MLTDDGVPVEAVYEPCTAGFGASAGARAEPAADTPVIVVAHGFTGSVDRPAVRRAARVFSQRAAVITFSFRGHGRSGGRSTVGDREVLDLAAAVAWARTLGHRRVVTVGFSMGGSVVLRHGALYTDGSEARDAAVRVPVRERRTGEHSGAHVGAHADVVVAVSAPARWYYRGTAPMRRLHWVVTRPSGRLVGRYGFRTRIATEDWDPVPLSPVAAVPLIAPAPLLLVHGDRDPYFPLDHPRMLADAAGEGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE35</accession>
    <name>A0A7K2ZE35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000722">
        <property type="protein sequence ID" value="MYW30627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="75"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="356" mass="37574" checksum="E4EC3989A9B96AAD" modified="2021-04-07" version="1" fragment="single">MAAASSTSNSKALRREAVDTALAALGLDDKARLLAGQDLWSLPALPAIGLRSLVMSDGPIGVRGVRWTAADPSIALPSPTALAATWDPELARHAGRLLAQEARRKGVHVLLAPTVNLHRTPLGGRHFEAYSEDPYLTGEIGTGYVRGVQDGGVGTTVKHFVANDAETDRFTVNNTVAPRPLRELYLAPFERIVRNAHPWGIMAAYNQVNGSTMTEHRYLQNAVLRGEWGFDGFIVSDWLAARTTVGAITGGLDAAMPGPRTVYGEALADAVRAGEVDEKIVDIAVRNILLLAARVGALESAPPAVAPADLPATVDGEALAREIARRSFVLVRNEVRDGAAALPLAPGTTVALSGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEB2</accession>
    <name>A0A7K2ZEB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000733">
        <property type="protein sequence ID" value="MYW30697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018488026.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000733.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="118"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="372" mass="40350" checksum="36A7A01E1EDF124B" modified="2021-04-07" version="1">MPARGLSPIGLEAVGSVAVRTFATQQHMTTAPQMMDGLHVNATAGNESGRNTDRFADFAEVPEGHFYDPDAEYEPDPEYAATLAPDAARQRRERIGPTGRPLPYFPIPGPLTDHGPAKIIAMCNQKGGVGKTTSTINLGAALAEYGRRVLLVDFDPQGALSVGLGVNPMELDLTVYNLLMERGMAADEVLLKTAVPNMDLLPSNIDLSAAEVQLVSEVARESTLQRALKPLMADYDYIVIDCQPSLGLLTVNALTAAHKVIVPLECEFFALRGVALLTETIEKVQERLNPELELDGILATMYDSRTVHSREVLARVVEAFDEHVYHTVIGRTVRFPETTVAGEPITTYASNSVGAAAYRQLAREVLARCHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEC7</accession>
    <name>A0A7K2ZEC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000730">
        <property type="protein sequence ID" value="MYW30668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029528851" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="52" mass="5032" checksum="5186326D7062FD99" modified="2021-04-07" version="1" fragment="single">MMTMIEVLLVQASLSRLASRAGARPAAATLLAVALAAVTLGPAASPAAAATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEL3</accession>
    <name>A0A7K2ZEL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000762">
        <property type="protein sequence ID" value="MYW30793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="14624" checksum="0FA151774526D84E" modified="2021-04-07" version="1">MGDGAALVDRIAERRAGVGDPRALVGELRRALVLVPYDRGGLWTAELGGIRWVCGFTDEAALARFAEERAAVEGAGAASRSWEYATFRGARLLDEVIPAMGVPAGVAVNVADPDGSMLFPPGVGIVPDSYAVDADVPSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFD4</accession>
    <name>A0A7K2ZFD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000829">
        <property type="protein sequence ID" value="MYW31063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="59"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="207" mass="22512" checksum="178B8C5AC91D87F9" modified="2021-04-07" version="1">MAPGHVAYGLAAQYGLRIPAETVVAWERGLATPGERELTALAGVLWCAPGELLAAAATLREHRMSRELSVDDLARQLGMTGASYLRMEETGRWKGNERQSAALCRALGLSPAQFLTATGRDEELAELLTSAVTTRWQAYVRPVAKIVPLDRGQIQDILEQLHADYQALMVSTLSWSSTGQERSATTGDAGRAFLARVVDQFWRTAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFQ6</accession>
    <name>A0A7K2ZFQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000865">
        <property type="protein sequence ID" value="MYW31207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="21907" checksum="4E1A282CCECB0DC6" modified="2021-04-07" version="1">MNDQLMVATALTVADWNRRQGATERPLRITMPVDDRTRGPEMPIGNGTRLVEVGFDAAEVAAGRDIAGLLRLTAERTRALKGQPRPQLGRSTSLLTTPLLPVAVRAAYTRGLRVLAGPWTSTTLLSNVGRIPYPLDFGDAGSSQALWISAPARMPRGLTFTTASTNGRLHLALRWSRTLLGDADGEALLGLFTRHLAATSSEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFX7</accession>
    <name>A0A7K2ZFX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000873">
        <property type="protein sequence ID" value="MYW31267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="30209" checksum="972EB68BFDBC553D" modified="2021-04-07" version="1">MNRDATPRRYLMCAPTHFRVTYSINPWMDPSKPVDLPLAQTQWEDLRDRYRSLGHTVELLTPRPDLPDMVFAANGATVIGGRVLGALFAYRERFEEAEAHREWFRENGFTDIREPDHVNEGEGDFAVTASYLLAGRGFRSSPLSHDEAQEFFGLPVIGLDLVDPRYYHLDTALCVLDAAADEIMYYPDAFSPGSRAVLRRLFPDALLAREPDAAAFGLNSVSDGRHVLLPQAATGLLDPLRDRGFEPVPMDLGELLKGGGSVKCCTQELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG38</accession>
    <name>A0A7K2ZG38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000892">
        <property type="protein sequence ID" value="MYW31324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="221"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="29247" checksum="A2994016B95D32AD" modified="2021-04-07" version="1">GNGYYGGLQFSQETWSAYGGDAFAERADLASRSQQISVAEKVLDDKGPQAWPSCAVISGLAVDGSLPGVDPGTAPSSDPTQDPTTAPADEADEKGEAGGSGNTGSTGTTGRTGTTDSTDKTDGTGKGEKKGGADTLDPSAKPSTPPATGKTGTSGSPDASQPSTSAPDASQGTDRTGGKHRGAPAPEEAGAVGQEGGPRESGRHASRGEGDARDGSAVTDGGYTVQPGDSLWAIADAQELPQGWTGLYEANKDLLGSDPDLILPGQSLDLGLGQSASEGAETGADAGAGTGAEAPAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG45</accession>
    <name>A0A7K2ZG45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000872">
        <property type="protein sequence ID" value="MYW31265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12711" checksum="9754CDCCEE6EA47C" modified="2021-04-07" version="1" fragment="single">MTELPAVHAAHTFELTAAVRDEIRTLLDSAFEGDFGDDDWEHSLGGVHALVRDTGGLLIAHGSIVQRRVLHDGRSLRVGYVEAVAVRPGRRRQGLGHRVMGALERVVDGAYEFGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGF7</accession>
    <name>A0A7K2ZGF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,2-phenylacetyl-CoA epoxidase subunit A</fullName>
            <ecNumber evidence="2">1.14.13.149</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">paaA</name>
        <name evidence="2" type="ORF">GT040_19495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.149" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000911">
        <property type="protein sequence ID" value="MYW31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097266">
        <property type="term" value="F:phenylacetyl-CoA 1,2-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011881">
        <property type="entry name" value="PaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02156">
        <property type="entry name" value="PA_CoA_Oxy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="353" mass="39163" checksum="611A9B453B0842A0" modified="2021-04-07" version="1">MAAVTADQKTQSTSGTAKAAGQAAGTAPDVADAARLAVFDAAVAADDRIEPRDWMPEAYRATLVRQMAQHAHSEIIGMQPEANWITRAPSLRRKAILMAKVQDEAGHGLYLYSAAETLGTSREELLDKLHAGRQRYSSIFNYPTLTWADVGAVGWLVDGAAITNQVPLCRCSYGPYARAMVRICKEESFHQRQGYELLLALSRGTEAQHAMAQDAVDRWWWPSLMMFGPPDGASSHSEQSMAWKIKRHSNDELRQRFVDICVPQAEALGLTLPDPDIRWNEERGQHDFGAIDWTEFQEVLKGNGPCNEQRITQRRRAHEEGAWVRDAAAAYAAKHTTPSTRTAQPAQHVEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGH0</accession>
    <name>A0A7K2ZGH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_19815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000924">
        <property type="protein sequence ID" value="MYW31461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029724967" evidence="6">
        <location>
            <begin position="23"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="49"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="468" mass="50436" checksum="25968178A3CF0FB1" modified="2021-04-07" version="1">MPRRNLSRLTIAGVTIALLASAAPAAVAGPDRGQSSGGDRSKGHHRPAYKNIGYFTQWGVYGRDFQVADLQTSGSAAKLTHINYAFGNVSAEGKCFTGNIAGQADAWADYARPLDAANSVDGVADTDTQPLAGNFNQLRKLKAKNPGLKVMISLGGWSWSTHFSDSVRTAASRKALVASCIDLYIKGNLPQDGVRGGQGAAAGVFDGIDVDWEWPGSAANEGTVFRPEDKKNFTALISEFRTQLDAYAKSRAKSAKSAKGKGHGHHKPKPKHYDLSAYVPANPKAIDAGFDVKRLMKDFDFVNLQGYDYHVSGEKKTAQQSALYAKNDFSVDQTVRDWVKRGAPKHKLVVGMPTYGQGWTGVSGGGKGLGQPATGPAPATWANGYEDYKVLKKLAASGTFKVHRDTKNGHAWLFDGTTLWTYDDPQVLRAKTSYIRDKGLGGAMFWSLDGDTDDGELVTTVDRGLNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGH2</accession>
    <name>A0A7K2ZGH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000923">
        <property type="protein sequence ID" value="MYW31454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="85" mass="9185" checksum="FDB023C934019D01" modified="2021-04-07" version="1" fragment="single">MTEAVTARAPGGAQAVRRALDVLHCFHDNGPDLSASDLARRLELSVSTAHRLARTLLGAGFLEQDPRTARYRLGPAVTELGRLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGH9</accession>
    <name>A0A7K2ZGH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_19795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000923">
        <property type="protein sequence ID" value="MYW31457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="284" mass="30225" checksum="5BA04BF7C2C29270" modified="2021-04-07" version="1">MSDTRVVAQAADPPLPGLVTPRPQLRKPRSRPYALTVRALGPFVLLGLWWAASATGLITPDVLASPAEVLKAVGELWGNGQLPDALATSLTRSGLGLVIGLAAGLTLGITTGFTRLGDELLDSSLQTLRTIPFLSLVPLFMVWFGINETAKILLIAVATTFPMYVSASSGVRNTDPKLVEAMRSFGMSRLAIVREVVLPGALPSLLAGLRLSMTLSVIALIAAEEINATAGIGYLMSQAQSYARTDILAVCILVYGLLGLTADVLVRLLEHFLMPWRTPQGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGJ2</accession>
    <name>A0A7K2ZGJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_19630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000915">
        <property type="protein sequence ID" value="MYW31425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076967928.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000915.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="31511" checksum="77F13342B4A9E901" modified="2021-04-07" version="1">MPPQTDLLPPSSSAPPVKNDGDSAVPRIVPVRRTGRWTAAVAVLVLLALALNSVIRNEAFEWDVVVSYFATVSVLRGLWLTLWLTAVVMVLGFALGALLAVLRLSGNPVLQAVSWGYVWLFRSTPILVQLLFWFNIGALYPQILGVNTVTLMGPVTIAVIGLTLHEAAYAAEVVRGGILSVERGQIEAAQSLGLGPWRRFRRIVLPQAMRSIVPPAGNMLIGTLKGTSIVSIIAVQDLLYSVQLVYHRTYQVIPLLLVATIWYALVTSLLSIGQRYVERYYARGTAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGT7</accession>
    <name>A0A7K2ZGT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidyl-Asp metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000942">
        <property type="protein sequence ID" value="MYW31525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029481324" evidence="1">
        <location>
            <begin position="30"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="30697" checksum="422AFD45F4B06F68" modified="2021-04-07" version="1">MRAPLLKVVLAVGIAASLCAAPFLTDTSASAPATPAAASGSTSAAASGVVRCPVVDVLVVHTPRAAERLGGEHRVPASAQRIATRMNRSLAADGLCGIIRVVHPYTAKDYDGSEEFRAAYAVLKDHTSGLGRQVHEQRERYGADLVTLVVERAERGGGTADYTPALDSSTHEYAYAVVEVDGIELDSASHEIGHNLGLAHDRTTLATDGGGAMNVSRTRPYNTGWITEDGRHYTLMAYRAACGTHCKRISRFSSAEGLWKGHRLGDASNDSVRVLRETMPIVAGYRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH96</accession>
    <name>A0A7K2ZH96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001008">
        <property type="protein sequence ID" value="MYW31733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KR" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="17840" checksum="D59DEAE3232056F6" modified="2021-04-07" version="1" fragment="single">LAPFVFPHDGDVPAGVREATGRALALAQRWPTDDRAADTPLVVVTRGAVSAGGSGVSDLVAAPLWGLLRSAQSEMPGRIVLVDLDDDPASVAALASVIASGEPQVAVRGGAAFVPRLERTTLPGEGQAEAGPWNPRGTVLITGGTGALGALFARHLTRVHGVSHLLLVSRSGPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHA0</accession>
    <name>A0A7K2ZHA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001007">
        <property type="protein sequence ID" value="MYW31732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12136" checksum="FA826825C02E37C0" modified="2021-04-07" version="1" fragment="single">MPADRSEALPAARRPHRFAGGQPGLLEPGASTDPYRLRLYRILRTDFPLGYDPGLGAWLLSRYADVALALTDPRFTGYPRDGAPRGPVPAPLGLCRGSLVCTPLPGSGTAPVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHB7</accession>
    <name>A0A7K2ZHB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_21160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001002">
        <property type="protein sequence ID" value="MYW31718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="27169" checksum="6086C7DD4F9CDD60" modified="2021-04-07" version="1">MASVPAVLNSEWTKIRTVSSTTWTLISAFVVTVAMGAGVSALVNSTFDDLSESEQLTFDPTLISFSGTVLGQLAMIVFGVLVVGTEYSSGMIRTSLAAVPQRGTLLFSKITVAGVLALVVGLLTSFVSFFLSQAVLGDRGTDLGAENVLRAVIGAGLYMGLIAIFSMGVAAMLRSPMLAMGILIPFFLLISNILAAVPYAKDVIRYFPDQAGSKIMQVVPEAMGSDPSPYGPWAGMAIMVAWVVAAVLGGYLVLKNRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHN4</accession>
    <name>A0A7K2ZHN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage holin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513841.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001015.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13433" checksum="05AA2A3C91254102" modified="2021-04-07" version="1">MKNFAVKTIANAGALAVAIWLIGNITLEGGSTGRKILTLILVALIFGLVNFLVKPLVQLLTFPLFILTLGLITLVVNALMLLLTSWLAGVFDLSFHVEGFWTAVLGALIISVVSWALNMVLPDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHT3</accession>
    <name>A0A7K2ZHT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001054">
        <property type="protein sequence ID" value="MYW31911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="12273" checksum="F54B4E8B3C5E0CBC" modified="2021-04-07" version="1" fragment="single">ARLAGLARATVAQLAALHSPFDLEIVLISTDRARSPEERRREWSWLGWLPHLRPMHGQDCRLLLAYDREQAAARTAELVRRLDEGPLGPGWPNLDRTGVADAARAHTGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHX4</accession>
    <name>A0A7K2ZHX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_22330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="489" mass="52716" checksum="9718B02E04C06B55" modified="2021-04-07" version="1">MTEHTELVEHGKLFIGGEFTDPLGTGVIEVISPHTEQVIGRVPHASEADVDRAVAAARHAFDEGPWPRMTLDERIAVITRIKDAFAVRYEEFARLISAQNGTPYSASVMVQALAAMMVWDSAITVARTFPYEERRDGVLGPLLVRREPVGVVAAVVPWNVPQFTAAAKLAPALLAGCTAVLKVSPETPLDAYLLAEIAAEAGLPPGVLSILPADREVSEYLVAHRDIDKVSFTGSVAAGRRVMEVASRNLTRVTLELGGKSAAVILPDADLEAAVAGIVPFAWMINGQACVAQTRILAPRSRYDEMAEAFAAAAGALRVGDPLDPTTELGPLVAQRQQQRSLDYIKLGQEEGAKILTGGSRPASQERGWYVEPTLFGSVDNSMRIAREEIFGPVICLIPYADEAEAVRIADDSPYGLSGSVWTADTERGIDIARRVRTGTYSVNTFSLDMLGPFGGYKNSGLGREFGPEGYGEFFEHKMIHLPAGYREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI72</accession>
    <name>A0A7K2ZI72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001075">
        <property type="protein sequence ID" value="MYW32060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="20997" checksum="7C4F412B4A104B5A" modified="2021-04-07" version="1">GRPSRQAAAEGPDARTRILQAARTEFAERGYDKTSIRQVAKAAGVDAALVHHYFGTKDEVFAAAVELSFEPALVIPAVLGGPPEGLGERLARYFLSVWENPATRAPLLAVLRSALTHEAAAKVLRGFVLRRLLERIAADLDIPDATFRAELAASHMIGIAMLRYVIRAEPLASADPEDIVAMVAPTLQRYLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIB9</accession>
    <name>A0A7K2ZIB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14180</name>
        <name evidence="3" type="ORF">GT040_23155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001083">
        <property type="protein sequence ID" value="MYW32091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="17704" checksum="A7AAE946F66F8CDE" modified="2021-04-07" version="1">MADESIAPLDRLTVERACERLIVRFVHELDLGEPDRVAELFTADGVWEWPEGDRRIEGRDALRGYFGARPADRLSRRICTNILVTLTSASTATATTYFTTYRVDGHSGGMLPPRPPTQVGHYEDTFRNVDGRWLLSRRVLFLAFGGPTENVTMYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIM9</accession>
    <name>A0A7K2ZIM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001111">
        <property type="protein sequence ID" value="MYW32201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="187" mass="20775" checksum="61B44DABD04EAE6A" modified="2021-04-07" version="1">MRDQAFELLLLREEDLDESFFGEEPSAAYDPAYVSGDASGRVIVDLTNMLTHGTHPETLRHGSALFTNVVGSVVFHHVAQFGNDAAQKIYEELHTAVQDCASYRMELNDGVQIDITRVALETAEIGDDGFLVRWLSTVDHFRVDTSWVVARKGDVLTFVNTRVPDQEEALKLARVSVARLENPDGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIX4</accession>
    <name>A0A7K2ZIX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_24305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001137">
        <property type="protein sequence ID" value="MYW32306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="12299" checksum="BD35BCB850005562" modified="2021-04-07" version="1" fragment="single">MDQMALLLLLLLGAVVTVPLGARLGLPAPVLMTLAGVAMAFAPFVPNVDIPPEIILPALLPPLLYASVQRTSWRQFAANKRPIFLLAVALVFVTTAAVAAVANSVVPGLPIAAAVALGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJC2</accession>
    <name>A0A7K2ZJC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prepilin peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_25115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001176">
        <property type="protein sequence ID" value="MYW32460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="4">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="14353" checksum="2173FE5D6D26ABA8" modified="2021-04-07" version="1">VLLASVDRRVHRLPDPLTLPLAAAAVLLLGGAALLPGHAGSWVSGLLGGLVLGGFYLLLFLINPNGMGFGDVKLALAMGVALGWYGWEVLFLGGFAGFLFGAAYGLGLVLLRRAGRRTGIPFGPFMIAGALTGVLLGALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJJ1</accession>
    <name>A0A7K2ZJJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030560950.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001194.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="9400" checksum="04D8C03D4C6F001E" modified="2021-04-07" version="1">MSECAHVADLPRPEPVPLGETCPECLAAGTHPVQLRLCLTCGHVGCCDSSPLRHATGHFRETGHPVMRSFEPGESWRWCFEDGSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJK9</accession>
    <name>A0A7K2ZJK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="21627" checksum="A724F0D425D7F9FE" modified="2021-04-07" version="1">MTDIPLSSALTRLCDPVDISGHRNNTAISAATETKAGAFNVWGNSFAAEYLPAGESLVHVDGIPFRFPPVCEGPDNVRCAGQFFGVPEGRYDWLHLLAASERRCEDTVELHFADGTLDAEPLRISDFWSAPAWFGEVKAFESLVMHYPHHVQRSVSAVMWAQRVPVTRRAVLTGVRLPRNVAVHVFAATVQRTEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJS1</accession>
    <name>A0A7K2ZJS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001202">
        <property type="protein sequence ID" value="MYW32602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="97"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="399" mass="44895" checksum="342E7C0153AB07A7" modified="2021-04-07" version="1">MTDTELPRIVSVDDHVIEPAHLFSTWLPAKYRERGPQPLTAGIGELAYTGGKYVITMDPDGPPTDWWIYEDLRFPYKRNIAAVGFDRDDMTLEGITRAEMRPGCWDPAERLKDMDLNHVEASLCFPTFPRFCGQTFAEAHDKEVALACVRAYNDWMVEEWCGDSAGRLIPLCIIPLWDIGLAVAEIKRNAARGVRAVTFSEIPTYLGLPSIHTGYWDPFFAVCQETGTVVNMHIGSSSQMPAASPDAPPAVQASLSFNNAMASMMDFLFSGVLVKFPTLKLAYSEGQMGWIPYALERADDVWEEHRAWGGVRDLIPEPPSTYYYRQMFCCFFRDKHGIASLDVVGRDNATFETDYPHVDSTFPHTKEVALDHVKGLDDETVYKLMRGNAIRMLGLDLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJV3</accession>
    <name>A0A7K2ZJV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">rbfA</name>
        <name evidence="3" type="ORF">GT040_25960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001206">
        <property type="protein sequence ID" value="MYW32624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="17386" checksum="981F494D16405218" modified="2021-04-07" version="1">MTDNARARKLADRIQVVVAETLDRRIKDPRLGFVTITDARVTGDLREATVFYTVYGDDEERAASAAALESAKGVLRSEVGRQTGVRFTPSLAFVPDALPDNARTIEDLLDKARARDAEVREVSTGAKYAGDADPYRKPEDEDDEAETPGSTDKNEGPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJZ3</accession>
    <name>A0A7K2ZJZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001218">
        <property type="protein sequence ID" value="MYW32672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="155"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="294" mass="31772" checksum="E06EB016B6867AF1" modified="2021-04-07" version="1" fragment="single">METEPQTQAEETAEVPGALPEALTGFVGYLLRRVFARFAACSDGPEDGSRDFLVLDALTGGDWASQLDLAERLGINRTLMVGVVDRLEGRGQVLRTRNPDNRRQYILSLTGEGRSAVEAGRRAVAERDARLTAALTAEQVPRLNTLLARLLPPGAQDLVRGTEHLVAQAHHRLRRLGDEKLAGTGLRVRHYGPLSLLATSGPCPQQRLARELAISGPATSQLVDELVAGGMVHRGRDPHDRRRHALELTELGHTQLKRVAEAVGLLAAETAELLGPGGADELRALLGRLLEPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK52</accession>
    <name>A0A7K2ZK52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001207">
        <property type="protein sequence ID" value="MYW32629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="22759" checksum="D290C44FC4922AF6" modified="2021-04-07" version="1">MLLMEQNNDELDSLVRKRIRALRVAQGWSLEELAGRANLSQSSLSRIENGQRRLALDQLVTLARALDTTLDQLVETASDDVITSPMIDGAHGLMRWTVKGDPGMTVVRQRMTEPPPDNPARMRAHPGREWLVVLSGTAVLMLGHRRFRVETNQAAEFPTMLPHAIGAEGGPCEILGIFDRDARRGHLRENRSTGNDCAPDLPHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKB7</accession>
    <name>A0A7K2ZKB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001253">
        <property type="protein sequence ID" value="MYW32796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="292" mass="30141" checksum="2CD6268251CAC9BA" modified="2021-04-07" version="1">MVVQQYRDGGGARAARALAVAGVIAVTAGCVGGGGGNGGSDGSGQRAVAAERPLDVLGRAAGVLAEAGGAEARTSMETAAGGTRVTIRGEGTYDFRTQMGRLKVVLPTDAAGADDRRPITELLAPGALYMKHRGAGVPDDKWVRIDTTALEDGNLVTGGVTDPMAAAELLRGAADVTYEGKSELAGVTVHHYRGVADLNRAARAASPQSRGALSAAAKGFSKDAVPFDAYLDEEGRLRKVRHRFSFASEGREGQEAAEVTVVSTLLLYGFGAPVTVKLPDEDDIYTGEIRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKS1</accession>
    <name>A0A7K2ZKS1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">grpE</name>
        <name evidence="7" type="ORF">GT040_27645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001297">
        <property type="protein sequence ID" value="MYW32946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="201" mass="21623" checksum="D4AD424B94361885" modified="2021-04-07" version="1">MTRHPEEPDRAASVGPAPKDAVSPPGEAAHQPGPPLRPQATADEARPDADVPASAAAEHAAAVRELEDRWRRALADLDNLRKRHARELERERMVERSRTAAAFLPVLDNLELALSHADADSGAVVEGVRAVRDQAVGVLEQLGYPRHAETGVAFDPAHHEVVSVVDDPDIEPGTVVQVLRPGYGDGDRQLRPAAVTVAKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKW8</accession>
    <name>A0A7K2ZKW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl Co-A mutase-associated GTPase MeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">meaB</name>
        <name evidence="3" type="ORF">GT040_27830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001299">
        <property type="protein sequence ID" value="MYW32980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073879148.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001299.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="47"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="320" mass="33229" checksum="5E2EE0618B619DDA" modified="2021-04-07" version="1">MDVDVPTLVEQARAGRPRAVARLISLVEGASPQLREVMAALAPLAGHAYVVGLTGSPGVGKSTSTSALVSAYRRAGKRVGVLAVDPSSPFSGGALLGDRVRMSDHASDPGVYIRSMATRGHLGGLAWSAPQAIRVLDAAGCDVVLVETVGVGQSEVEIASQADTSVVLLAPGMGDGIQAAKAGILEIGDVYVVNKADRDGADATARELNHMLGLGESRGPGDWRPPIVKTVAARGEGIDEVVEALEKHRAWMEEHGVLAERRAARASHEVETIAVTALREKIADLRGDRRLHALAERIVAGDLDPYAAADELVAGLTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL87</accession>
    <name>A0A7K2ZL87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001318">
        <property type="protein sequence ID" value="MYW33106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="442" mass="45510" checksum="AF53163EDA48A3E5" modified="2021-04-07" version="1" fragment="single">MRSTAHHADVIIIGAGIAGLSAAHLLTGAGVGVSVLEAASTVGGRLATHEVDGFRLDQLGPLLCTSWPELTSTPGLGTPELRKFAPGVLVHSEGRRHRTGDIRSARGALRAVRSRSSAPQASPGGYGGQLRIASRSGLGAKTPGLRSSTTMSEAIDRARLGSALSRLAATPTARLLARPERTALAALRAGQMPARTVDGVLRPLLTALLGDPGLTTSSRYADLALRDYARGGLCVPAGGSGTLPDLLAAALPPGTVRTGVHVTAADITTVRTKEHGELGCRSLLLATGAGAAAELLPGLRVPAFRPVTVLHHTAPAPPPTGRSLVLDGDRSGPVAYTAVMSEVDPSRAPEGRTLITSTVLGTPPPDLDRSVRTHLAALYGTPTGDWELLAAHHDPEAVPAMEAPHDPRRPVRVLAGLYVCGDHRDTSSVQGALHSGRRAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLN8</accession>
    <name>A0A7K2ZLN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_29360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the phytochrome family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001360">
        <property type="protein sequence ID" value="MYW33262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHYTOCHROME_2" evidence="3">
        <location>
            <begin position="187"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="396" mass="42391" checksum="7CACC70F73CACE9E" modified="2021-04-07" version="1" fragment="single">MGRSGDVRGSDDVHGSDDVRGWLSPKAVAAEAGVSQEFDLSQCVREPIHLLGGVQSYGALVAARLHDAVVDTVSRNAGDVLGRAAGELVGRPVTELVGDEQWALARESTEAAGAGEGTPDGPAASGVLSLSLESDDGRVRLFDVTVHRVAELLVLEFEPRAADGPFVFQNFYPRVRRALHRLQGATSVTECCAAAVREVQALTGYDRVVAYRFDGAEGPGQVIAEVRNEGREPWLGLWFPASDIPPQARRLYARNWIRVIGDVDDATVGLLPELREGTGEPLDLSGSILRTVSGYHLEYLRNIGVASSMSVSLLRDGGLWGLIACHGDEPRRLTPEVRAACEFFGIALSLQLAAVAEREQADELSGRRRALAALLARLSSQEPDALLRPGSGMAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLQ6</accession>
    <name>A0A7K2ZLQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_29465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001363">
        <property type="protein sequence ID" value="MYW33281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="356" mass="36436" checksum="F9BF17D681A6A5F3" modified="2021-04-07" version="1">MSGSTLLAKEKPADGGTKEARARRSRPVLALGLLAALGVLVLVVVASLAIGSGDVPFRDVLPGVFDPDLTVKGQLVIQEVRIPRTVAGLLAGAALGLAGTVMQGVARNPLADPQLLGINAGASVAVVCSITLLGFTVATQFIWFGFLGALLAALLVYGVGSLGREGATPVKLALAGAATSAVLTSVTSAILLQDRGSYDQFRFWQLGALTARSSEVLWQVAPFILVGAVLALGLGPQLNALSLGDDLARGLGQRVGAARMVSAGAVVVLCGAATVVAGPIGFVGLAVPHAARLITGPDYRWVLPYSMVLAPIMLLVADIIGRVIAPPGEVQVGVITAAIGCVPFIWLVRRRKLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLX5</accession>
    <name>A0A7K2ZLX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_29660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001372">
        <property type="protein sequence ID" value="MYW33318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="158"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="276" mass="28367" checksum="0FEACACA82452EA9" modified="2021-04-07" version="1">MKPIITASEYASESAGPRPPVLLDVRWQLGGPHGRPDYEAGHLPGAVFVDLDTELAGPAGSGGRHPLPAPEAFGAVMRRAGVGQDTPVVVYDGGQGWAAARAWWLLRWTGHPDVRVLDGGLAAWNGDLSTGIPDPAEGDFRPKPGALPTLDADAAAALARTGLLLDARAAERYRGDVEPIDRVGGHIPGAVSAPTTQNVAEDGCYLPAERLAERFTGLGAGKSGEAVGVYCGSGVSGAHEVLALEIAGIPAALYPGSWSEWSADPARPVATGPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM88</accession>
    <name>A0A7K2ZM88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_30505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001403">
        <property type="protein sequence ID" value="MYW33483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
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            <begin position="52"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="315" mass="34144" checksum="DBC79127A9579A1E" modified="2021-04-07" version="1">DAAAHRLARLAALTDDEGQALVPAAHPSRWWGLDEPTRSAVPLRDRDQPVTLSGSALDQLANTCALQWFLGREVKADAPATAAQGFGNVVHVLADEVASSRTPADLDVLMERLDSVWNGLAFDAPWKSEQEKDQARAALERFLKWHVLDRGGRTPTASEHDFDVTLEAGEYAVRIRGSMDRVEQDAEGRAYVVDFKTGKSAPTKDEVAAHPQLAVYQLAVREGAVDEVFDGRRPEPGGAELVQLRQPAPKKEGGDALPKVQAQEPLAGEWVSDLLATAAGKVLDERFTPTTGTHCTHCTFRASCSAQPEGRQVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM92</accession>
    <name>A0A7K2ZM92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6153" checksum="AA701E8631EB3DC7" modified="2021-04-07" version="1">AALVAFRPLLTAVAVVSGTVRSAPRLPRAAGRVHPLSPARFPVHSVGRRGPPLTAYATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMD2</accession>
    <name>A0A7K2ZMD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ethanolamine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eat</name>
        <name evidence="7" type="ORF">GT040_30550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001406">
        <property type="protein sequence ID" value="MYW33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004757">
        <property type="entry name" value="EtNH_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00908">
        <property type="entry name" value="2A0305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="198"/>
        </location>
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        <location>
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            <end position="240"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="489" mass="51115" checksum="5FA7B6A10BCC21ED" modified="2021-04-07" version="1">MAQGTETPAGPPDSTSPGATGSAAYLRRRTLRRGSAGWLLLTGLGVAYVVSGDFSGWNIGLSKGGFGGLAVAMVLMGVMYACLVFALAELSAILPTAGGGYGFARRALGTWGGFLTGTAILIEYILAPAAISLFIGDYVESLGLFGLTSGWPVYLACFAIFIGIHLWGVGEALRFSLVVTAIAVAALLIFAVGAFTEFDASRLNDIPADPSAFGSNSWLPYGLLGIWAAFPFGMWFFLGVEGVPLAAEEAKDPVRSMPKALAISLAVLVFLALITFVSATGAQGADAIKEAGNPLVVALQGDGEPTALSRFVNYAGLAGLVASFFSLIFAGSRQLFALSRAGYLPRFLSLTNRRKSPYPGLLIPGVIGFTLAAWSGNGGRMLNVAVFGATISYALMALSHIVLRRREPDLPRPYRTPGGARTSGVAFVLACSALVATFLVDRDAAFIALGVYAVALAYFAFYSRHRLVAAAPEEEFAALAAAEAELKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZME4</accession>
    <name>A0A7K2ZME4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001409">
        <property type="protein sequence ID" value="MYW33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="164" mass="16452" checksum="908BE98C1FF4E91B" modified="2021-04-07" version="1">MLAGAIGDGAFKVVLGAAFAGGSAWLDDLFGVEAWLVLIAGAALLIGGGIEVVHVRRRPMATCLRLMIGYDIGWAVASAVALVVAWQGGTAGGEIGVAYLVVAPLALAALLVAAAATDVRPPATDVRLPTTAVQPPATDAQPTATDIQPPATHVRPPARDTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZME7</accession>
    <name>A0A7K2ZME7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_30490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001402">
        <property type="protein sequence ID" value="MYW33480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="58"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="563" mass="57764" checksum="4D0FC0B64C67A547" modified="2021-04-07" version="1">MGGTEARDGTDGTAAGNSAGGTEAGNDAGGTDGARGTHGTAEPGAPGALTTPRGRRPVVAALMLGMALAAIDGTIVSTAVPQIVGDLGGFTVFSWLFSGYLLAVTVTLPVYGKLSDTFGRKPVLIAGIILFLVGSLLCAAAWNMGALIAFRVIQGLGGGALQGTVQTIAADLYPLKERPRIQAKLSTVWATSAVAGPVVGGLLAGYADWRWIFLINLPVGAIALWLVVRHLHEPARPRPKTRPRIDWAGALAVFATGALLLTALVQGGVAWPWLSGPSLGLFAASAALAALTVVIERRAAEPIIPGWVWRRRTIASVNLALGAMGLLMVAPTVFLPTYAQSVLGLGPIAAGFVLSVMTLSWPVSAALSDRVYNRIGFRLTAIIGMSAALLILLAFPLLPYPGEPWQPALIMLLLGAALGLFQLPLIVGVQSTVGWAERGTTTASVLFCRQVGQSIGAAVFGAVANSVLAARLLDAPAPGLPDDLDAVARALEDPGALSAAATDHLRRAVDAAVDYVYIGAAGAAALALLALVVLAPRRFPVITETDGSKTDGTETDGKQDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMM8</accession>
    <name>A0A7K2ZMM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="10543" checksum="4E2C9A898257DF73" modified="2021-04-07" version="1">MSFSTVTDLFSGDLATVSAEIHNLRAALLTSDVQVTWEEAEGLSPGEIVTRYVAARGDHGMRHWLRSLAIEHDAAQRFGPRLVDELDGIDGVHTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMP9</accession>
    <name>A0A7K2ZMP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001437">
        <property type="protein sequence ID" value="MYW33643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="352" mass="38880" checksum="A74AED4B882C1D14" modified="2021-04-07" version="1">MRFSVLSLIGHDPHPLTGELPSPADRFEEVIATASVAEELGFDSYSVGERHAGAFLSSGPSVVLGAIAARTRTIRLLTGVTVVAILDPVRVAEDFATLDQISRGRIELVVGKGAEAGHFDLFGLDEERQWDLQKEKYELLRRLWTEEGVDWEGEFRPPLKNVTTVPRPYDGLPRIWHGSATSLNSPELAAEHGDPLFTANAIQPREAYAKLIAHYRERFEAYGHDPADARVAAGSGGLLIADSSQAAVEQYKELYEARVRQTFKPHLAGKAGYNTPFRTIEDAIAGGPQLIGSPQQIIDKILGWHTVYRHDLQSITVDGFGLSRPEQLETLQRFAEEIAPVVRREAPSTLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMR7</accession>
    <name>A0A7K2ZMR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="389" mass="41836" checksum="876972E1CA4025C8" modified="2021-04-07" version="1">MTDTTPTPADRPADQLRAAAAKLRAAAAAVPSDDWGTRAWHVEECSDTDTMESCPCIVAQGERKEFDQPQVPLIQYVADAETTEHAAWIALMHPGVGLALAAWLDTEAATWAGDEVHNSCSTQSCTFDAALAVARQLLGTSETAECGCDPAPHREDDGTYSHWAGCPIADEQQAADAGLEPDAGLRDRIAAAIRAESSRVDDLALADAVMPVVTDRLRRNWGQMRDRVAALETEAQRLVAAAPPAPADRAAVLRELAEEFRATFGEIIVCGTDGDWANVADWTATGARIPACGSFYPHHTDTRCVLHKGHRGSHRAPWGRRTMAWPYDRRETQPAAPAAPEEPTPAPQCSAGLLPATDEAVDRCVRHGAHDTHVTAAGVRWPNEDDPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNE0</accession>
    <name>A0A7K2ZNE0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nuoH</name>
        <name evidence="8" type="ORF">GT040_32425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001486">
        <property type="protein sequence ID" value="MYW33850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="466" mass="51040" checksum="EC6EAD489A6F7AC8" modified="2021-04-07" version="1">MGLTALTTAPQGAVIAAEDLSMFGTDPWWLVLVKAVFCFAFLMLIVLFSIVWERKVVAWMQLRIGPNRHGPWGLLQSLADGVKLMLKEDVIVKRADKAVYVLAPILAAIPAFMAVAVIPFGPAGNEVSIFGTRTTMQLTDLPIAALYILAVGAVGVYGFVLGGWSSGSTYPLLGGIRSCAQMISYEIAMGAAFASVFLYSGSMSTSTIVEAQGDRWYIILLPMSFLIYMVTMVGEASRAPFDMPESEGDLVGGFNTEYSSIKFAMFMLAEYIHMVTVSMIAVTLFLGGWRAPYPISAFWEGANHGWWPMLWFFLKLQALIFFFIWLRGTLPRVRYDQLMKLGWKVLIPVSVGWLMLVATVRALRNEGYDFSRIVLYVGGAVLAILLISLVVDMFRDRRVRAHEAEAGPEPAFDPMAGGFPVPPLPGQTLPPVPRRVPRRERELVVSGGPDTQSDGNASDGKEAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNG8</accession>
    <name>A0A7K2ZNG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dyp-type peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_32670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001492">
        <property type="protein sequence ID" value="MYW33895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="362" mass="39030" checksum="2FC386564A6B4EB0" modified="2021-04-07" version="1">MSAAVPDPVSVQPVVAPLTNAALFLVGTVEPGGEDAVREVLPDLAAVARSLGFRYPDAGLACVTGFGSAVWDRLFGGGRPAHLHPFQELRGRLHHAPATPGDVLLHIRAERMDVCFEWAAQLLTKLGGALRIVDETHGFRYLDHRDLLGFVDGTENPVGDDARSAALVGAEDDPEFEGGSYVVVQKYLHDLTSWNALSVEEQERVIGRTKLDDVEFPDDEKPADSHLALNTITDPDGTERDILRANMPFGNFGQGEFGTYFIGYAADPDVTERMLRNMFLGDPPGTHDRILDFSTAVTGGLFFAPRAEFLDDPPPPPDQVGAEDRPEPVSAPVRQGTLGTGTRTDGSDHGSLRIGSLQESAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNQ7</accession>
    <name>A0A7K2ZNQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001508">
        <property type="protein sequence ID" value="MYW33985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="14845" checksum="2FD4F1780121FDE5" modified="2021-04-07" version="1" fragment="single">MLTIHAAPLVLPVGAAAVAGGSGGGAVAVDGDRIAAIGPYEEVVAAHPAARVRRWPGLLTPGLRQDRARELLTRCYHPDPREADELGELPLSGEEFERLAATMDTARRSGSVRRGLQRMLRHGTTHVVGPFGADEPGLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP07</accession>
    <name>A0A7K2ZP07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001541">
        <property type="protein sequence ID" value="MYW34082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="18534" checksum="16AA0A9E44105F00" modified="2021-04-07" version="1">MTEIVHVSGPELVTYADEMAELLVETVEEGSSVGFLAPLDREKAAVWWRERAGAVESGEVSIWIAREGGRVAGTIALVRAPLPNARHRAEVAKLMVHPAARGQGVGRALLDAVEAYAQVESITLLILDTESGSLAEQVYCKAGWTEVGSVPGYAADPAGSLKPTTFYYKELAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP74</accession>
    <name>A0A7K2ZP74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001553">
        <property type="protein sequence ID" value="MYW34174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wyosine_form" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14661" checksum="E0F155A41C0D4C5F" modified="2021-04-07" version="1">TARLMETWAHGQDIADALGAARTPTARLRHVARIGVRARNYAYAVRGITAPETEFRVELRTPEDELIVYGPEGAAQRVTGPLLDFCLLVTQRAHRTDLAVTAEGPEADQWLSIAQAFAGPPGPGRLPRAERGGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ45</accession>
    <name>A0A7K2ZQ45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001624">
        <property type="protein sequence ID" value="MYW34455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="23211" checksum="C63EB29F1CEC0DED" modified="2021-04-07" version="1">MRQHTPVIATFCGARPGRDPAYAALAEDFGAALGRRGCGLVYGAGGVGVMGAVAGAALAHGAAVTGVVPHDLHERERSQKAPGQIFVVQSMHERKALMYRLSSAFAVLPGGFGTLDEFMEVATWNQLGMHRKRLVLLNTKGYFDSLLDFLDTVMREGFMTVEDRNLVCATDDVEEALDLLMSEPLEGVTAVTVPSPQARVPHEVIRPVPELRVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ64</accession>
    <name>A0A7K2ZQ64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4184 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001623">
        <property type="protein sequence ID" value="MYW34428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025238">
        <property type="entry name" value="DUF4184"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13803">
        <property type="entry name" value="DUF4184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="292" mass="31482" checksum="44C3CE32E6FCA60D" modified="2021-04-07" version="1">MPFTLSHAAAVLPVVRRNGTARWGLYPSALIAGSFAPDVTYFADTVIPGAMRFGDFTHTFLGVVTVNVLIAAVLVAVWAALREPLVALLPVRLRGRVHTFVRGQRWTRASFGPSAWLCFVRSAALGAATHVVWDAFTHHSRWGTELLLLDRSVGGFPLYQFAQYGSSALALVVLGWFLFTSLRRTVATPVPEALPELGRGERWGALGLLAGCAVLGIVHRCLRFYAHFGGIENPLDIIPTACFGAGAGLAAGLLLYGVWMRLLRGRGRPVESPEPVPVPEGSRAEESAADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQR9</accession>
    <name>A0A7K2ZQR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YbjN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18596" checksum="FD27CC1C3F79CAAB" modified="2021-04-07" version="1">MADVPDETAAAQVIEATLNEAGLSWESPAPGNYVVTLPGTRKLSTTCSLIVGKHSLSLNAFVVRHPDENEAEVHRWLLERNLRLFGLSYAIDSLGDVYLAGKLPLAVVTPEELDRLLGTVLEAADDSFNTLLELGFASSIRKEYAWRVSRGESTRNLDAFSHLIKRSSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQX7</accession>
    <name>A0A7K2ZQX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_37090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001683">
        <property type="protein sequence ID" value="MYW34745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="545" mass="57587" checksum="16874877492EBC1D" modified="2021-04-07" version="1">MGTDTSKGDGPESAPSGPAASGRRAGSPNQSLALAAMLFAVSMTFIDQTIVAIAAPDIIHELGLTSTQMQWVVNAYLLTLAAFFALGGRLSDIYGHRRVMLIGTLVFVISSAMCGAVPAGDFAQAWLIGFRAVQGIGAALMFPAALAVVIAVFPVERRGRALALFFGLSGALTAVGPLLGGWLTSWTWRAIFWVNVPVAVIAIVLTLLARIPDRSRREPLDLPGAALVAVGMGLTVLGLQQASTWGWSSVITWACIVVGLLVLAFFCWFELRARFPLIKLQVFRDRAFQIDNAVLFFSMMAFVPVFFFASVYAQVSLSASPNQAALYLLYFFIGFGLASQWGGRILDKRGARPALKLGTALGAVGFFLWAQKLTTLSMHDQWLYAAMAGAGIGLLLAPASTDAVNRAIGASYGEVTGITQTVRNFAASIGLAVFGTVLTHRTVTNVEGTLVGKGVPEGAAGDAAESVAQAVTGQADTRGPSGSGPVADAVKDSMQAIRMDFAQANQWVFYGMAIVLAIAFLFSLRHPGTRVTQDSPKDAEPAQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRG7</accession>
    <name>A0A7K2ZRG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S1 RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001737">
        <property type="protein sequence ID" value="MYW34990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="653"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="751" mass="81478" checksum="3D600BD1EBAC0834" modified="2021-04-07" version="1" fragment="single">MTTSIEGRIAEELGVRERQVRAAVELLDGGSTVPFIARYRKEATESLDDAQLRTLEERLRYLRELEERRTSILDSVREQGKLDAALEAAIRGAETKARLEDIYLPFKPKRRTKAQIAREAGLEPLADGLLADPSADPLAAAAAFVDGDKGVADAAAALEGARSILTERFSEDADLTGELRERMWTRGRLAAKVREGQEEAGAKFADYFDFAEPFTALPSHRVLAMLRGEKENVLDLVLEPEEPEAAERPGPSTYENMIARRFEIADRGRPGDKWLLDTVRWAWRTRIQVHLGIDLRLRLRTAAEDEAVRVFASNLRDLLLAAPAGTRATLGLDPGFRTGVKVAVVDATGKVVATDVIHPHVPANKWDQALATLARLAKEHAVDLIAIGNGTASRETDKLAGELIDKHPELKLTKVMVSEAGASVYSASAFASQELPDMDVSLRGAVSIARRLQDPLAELVKIDPKSIGVGQYQHDLSEVKLSRSLDAVVEDCVNGVGVDVNTASAPLLSRVSGISSGLAENIVTHRDTNGPFRSRKALKDVARLGPKAYEQCAGFLRIRGGDDPLDSSSVHPEAYPVVRRMGKTAGGEVASLIGNAEALRSLRAADFVDDMFGLPTVTDILRELEKPGRDPRPAFRTATFKEGVEKLGDLEPGMVLEGVVTNVAAFGAFVDIGVHQDGLVHVSALSKTFVKDPRDVVKPGDIVKVKVMDVDAQRKRISLTLRLDDEPGAGGGQGRGEGRGERGARPPKQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRH3</accession>
    <name>A0A7K2ZRH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001727">
        <property type="protein sequence ID" value="MYW34933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="23073" checksum="1575D014D4A55593" modified="2021-04-07" version="1">MSNPAQPPVSDAEATRATIEVTIWSLEQTSPADLRPAAVPEGDLRIVRSEVVLPEFSRFLYTAVGGDIRWTDRLGMAYEQWREELERPGAETWVAYVNGTPAGYVQLDAQDGGVVEIMYFGLIPAFRGRRIGGHLLSYGVERAWDLAERWPERRPTERVWLHTCSKDGPYAMDNYLRRGFRLFDTKTEVEPDVATPGPWPGAYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRV3</accession>
    <name>A0A7K2ZRV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001774">
        <property type="protein sequence ID" value="MYW35104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="175"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="382" mass="42460" checksum="7AC3CFD7A26F9EF7" modified="2021-04-07" version="1">MTADRAGSLTVTLCRDFREFGALAGEWDALHRRCATATPFQSHAWLHSWWISYGQEGRLRVLLVRRSGRLIGAAPLMLVHRPMPLLVPMGGAISDFFDILLDEEEAGYAVGALQRGLDRAARHTVVDLREVRPDASAQLLFGRWPGARSRLTDSTCMELPARPLGDLVGRLTGSRGQRLRAKLRRIEALDVEARKVPQDGVPAAIGTLLRLHELQWRDRGVNPEHLRARFSDHLVRSVDRMVGDGTAAVTEFRMGGEVVAANLTLQSGHLAGGYMYGADPGLRGQKVDVSTMLLREVSQQASDTGREVLSLLRGAEQYKNHWQPVTVVNQRLLLARPGLEPLLRLRESQVAVRERAVETVKTRFPAARDWHGRLTTLPVIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS97</accession>
    <name>A0A7K2ZS97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001799">
        <property type="protein sequence ID" value="MYW35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="24416" checksum="339DDEA8E8FE7344" modified="2021-04-07" version="1" fragment="single">MTGEAARVRQMWHLLEPLHAVLYYAPEAFEEAAALGYGTEERWASYFAWRAAPLGAVDAPEVVRAFHSFAPAMVDRYVPAVWAAAGPDAVLAARLRAVDRAYRALFGDRRVEGAGFAEAAALARRAAEATTPGVLGALGPANSALPWPDAPHLMLWHAATVLREHRGDGHIAALGAAGLDPVESLVSFAGVGAARPEVFASRGWGEQEWSAARQRLQERGLLAADGTATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSD5</accession>
    <name>A0A7K2ZSD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001829">
        <property type="protein sequence ID" value="MYW35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="31089" checksum="86D106F9D3A62996" modified="2021-04-07" version="1">MSIGEFRNDKARERFNAVYGRLLGRLWPDPRDTFDLPTSFGTTRVHRAGPPCSDPVVLLSGANGNSLMWHRYIEPIARRRTVIAVDTVGEPGASIQSAPLTGAEDGARWLEEVLAGLEATAAHLVGCSYGGWLALGHHLHHPGRTAALTLVEPAGFADPGRRFYAWLIAGGLAGMAPRALRPRLSRWVGNSAILETELMELGRASVGFRRALPPARVFSDEELRRVRVPSLFLLGEQSSLHDARQVAERVGALMPAAEVEVVPGASHALPTDDPELVAARILRRAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSE6</accession>
    <name>A0A7K2ZSE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_40090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001833">
        <property type="protein sequence ID" value="MYW35310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW35310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="31142" checksum="565FBFD33995FDE7" modified="2021-04-07" version="1">MVTLLRVKRPGRLAAEAAALLIAVAVAFPLYWMVLSAFKPAGEIQSTEPRPWTLAPSLDSFRRVFEQQDFGRYFLNSLLVAGTVVLLSALVAFLAATAVTRFRFKFRTTLLIMFLVAQMVPVEALTIPLFFLMRDFGQLNTLGSLILPHLAFSLPFAIWMLRGFVRAVPEALEEAAYIDGASRTRFLWQILFPLVFPGLVATSVFSFITTWNDFLFAKSFIISDTSQSTLPMALLVFFKPDENDWGGIMAASTVMTIPVLVFFVLVQRRLVSGLGGAVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSN9</accession>
    <name>A0A7K2ZSN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_40590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001845">
        <property type="protein sequence ID" value="MYW35401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="183" mass="19118" checksum="B0CF079CCC8466F7" modified="2021-04-07" version="1" fragment="single">MPDDAFEPGPPHPATVPPALPPAPATARLRVVVADDNPVVRAGLGVLLSGRADIQVVAEAADGREAYEKTLHHRPDVVLLDVRMPGVDGISALPHLVGIAPVLMLTYSRESEIVHEALRLGAGGYLVHGEFTADQLVQAVRDTRNGRAHFTATAADALLAHMRHGTAPNRAALPDGLGAALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5V1</accession>
    <name>A0A7K2Z5V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000002">
        <property type="protein sequence ID" value="MYW27719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="200"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="454" mass="47960" checksum="2F144FE86F94B6C7" modified="2021-04-07" version="1">MTARPISETVASLMPRARAELAELVAFPSVADPAQFPKSGCEAAANWVADALRADDFTDVALLDTPDGTQSVYGYLPGPEGAPTVLLYAHYDVQPPLDESAWLSPPFELTDRDGRWYGRGAADCKGGFIMHLLALRALKANGGVPVSVKVIAEGSEEQGTGGLERYAEAHPELLAADTIVIGDTGNFRVGLPTVTATLRGMTMLRVQLDTLEGNLHSGQFGGAAPDALAAMIQLLASLRDENGTTTVDGLAGDADWDGLQYPEAEFRQDAKVLDGVELIGTGTVADRIWARPAVTVIGIDCPPVVGATPSVQASARAQISLRVPPGHDAAEATKLLTAHLESRAPWGARVAVEQVGQGQPFRADMTSPAYTAMASAMRDAYPGQEMQSSGMGGSIPLCNTLASLYPQAEILLIGLSEPEAQIHAVNESVSPEELERMSVTEALFLRNYAESKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z611</accession>
    <name>A0A7K2Z611_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000013">
        <property type="protein sequence ID" value="MYW27777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="263" mass="28083" checksum="88A109059AE661B4" modified="2021-04-07" version="1" fragment="single">MYVQGLPEDDRDKALSEHARDLHFTGRRYQKAKTELVASGYLHEKRETVAGGRWRTVQVFSNFPLTDDQAARLRAGVPADGYELVSTGPVPTAHFPTVGAPSGPAVGGLLPADEELGKNESHPPTEADSGDGEQGERGQQGGPEGPGGLEEPEGSESLEGPEGLEGEASEEAFEGLVEEPSDGPEVALAERVLLSLRHEQRQLHLGVREARTLAGLAAEWLRRGVTAADLRRALCSGLPVEGVRTAVGFLAHRLREKLPAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z652</accession>
    <name>A0A7K2Z652_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000019">
        <property type="protein sequence ID" value="MYW27821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26830" checksum="6FC6D8A716F4F8C8" modified="2021-04-07" version="1" fragment="single">MTETQTKTSSPEIRAAAGAMDGLREDLIRPVFAYRPLPPLSPEGRFIRRLPDGLKRAVVWTPHALVLFAAFIVMMAGFANWHFRLFMGLVPAIAVAMTLVRPIAAFWASWIATLFCALLGSEGLWGPGAFMAQAVVMVVVAARTRPRTALWMWLLTLLFGVVLEGGDPSITAPMAVLTAFALLVVTVFQVRRAAEQEVRDAEREITVQRTVTAVERDRRTLLEERTTIARELHDVVAHHMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z656</accession>
    <name>A0A7K2Z656_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">kynU</name>
        <name evidence="7" type="ORF">GT040_00670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>H2O + L-kynurenine = anthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="WWKE01000019">
        <property type="protein sequence ID" value="MYW27818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="43"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW27818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="415" mass="44273" checksum="FAD7696A17037BF6" modified="2021-04-07" version="1">MSETSRDTVRDASRETFRERALKLDAADPLAAQRELFALDDGVYLDGNSLGALPLHVPARVQDVLTRQWGELRIRSWGESGWWTAPERIGDRIAPLVGAAAGQIVVSDSTSVNVFKAVVAATRLAALAGEGRDEILVDATTFPTDGYIAASAARLTGHRIVPVDPDGVPSALGDRTAAVLLNQVDFRTGRLHDLPALTAAVHAAGAIAVWDLCHSAGALPVGLDEHGVDLAVGCTYKYLNGGPGSPAYLYVAERHQAAFDSPLPGWNSHADPFGMTPDYAPADGSVRGRVGTPDIVSMLTLDAALDVWDGVSVDAVRAKSLALTDFFLECVEAYVPQGRVVSVTPVAHAERGSQVALRCAEAEPVMRRLIERGVVGDLRRPDVLRFGFTPLYVGFADAERAARVLAEVLEETRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6D4</accession>
    <name>A0A7K2Z6D4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_01020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000052">
        <property type="protein sequence ID" value="MYW27888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="8">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="9">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW27888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="190" mass="21144" checksum="31FDC581DDBE2B2A" modified="2021-04-07" version="1">MKTTTTTDERAIAELQREHGPALFHFLLGLTFGDRQRAEDLVQETLVRAWQHPEAFDAPYESMRPWLFTVGRRLAIDARRSRQARPTEVSDLVLESTPADQDTADSAVRALDVREAVRTLSPEHRAVLVQIYFRGLSVGETAEALGIPAGTVKSRSYYALRLLSRTLPGYSRRSSARNSASRAEASATST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Q1</accession>
    <name>A0A7K2Z6Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000072">
        <property type="protein sequence ID" value="MYW28024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="758" mass="82075" checksum="45D952717097EB27" modified="2021-04-07" version="1" fragment="single">MLVRCEAESTPAVERHLTGADDDPESWLVSATGLLRASWSEGGRDCAVAAVAVLEYALDMGDREHPQRPRWVLHLWLAERTLARRFEDHRLSDEVQHHLAAQTQGRSADDPVAVAADYLEEPPPRHFEPPRRSHPNALRLADGLPADDLVRPCLLARLAQSAYFRLESGDATALEDAGRWADAAFTGITADHPEAALVCRTAVHTALTRFRDRPSDGRSVRLGLRAGRSALRAVEHSRRYGTGSVDVDAASAHLMFSLALTAFLPFDPDEEVVEEAIAQLQAFQACAPPDDKGVYAGNMPALLAVRAVLTGSPDDFRRSDELWAALQRDLPPDHPLSSHISDKRAACAKMAQMLERLPFNPGRLLQLARPLLRPLVIGVQLPPIRMSVPPGRPGVRSPGPGPEDFAPFVGASRPASADARTDRTGPVAVWPPGPPTDAGPAQPVSAADVDGLPADAAAMRSALLGAGASDPRRLALAVDQLHALLAEPLSDGRRGFAASILVQLLGAQFMFSEDLEDLERAVRCGDEQLALLPPTSSRYIELLCAVERHRHAYGELHQDESTVARATDALAWAVGRLPEMSASWLGCVLPYAHALAFVSRLRRDVTGTQKAVRLVELAARSLEGLPDRPEYAPELAALRAQLRPALATVTDLVRQAHDQVRWDVEADGTGPWDPAADRVLPPGARLENARIALGEAVKVRDWDRATEAGAAALEALPLVVSQALHREDRQAVLRTALLGRRYPAPPGRSRTPDLPDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6V6</accession>
    <name>A0A7K2Z6V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfonate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000082">
        <property type="protein sequence ID" value="MYW28052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="112" mass="11859" checksum="7489037DC3518FBC" modified="2021-04-07" version="1">DEPFGALDALTRIKAQRLVAELWQRRGCAVLLVTHDVDEALLLADRVLVMREGGIAYDTAVGLGRPRDVGAPGFAGLRSRLLSELGVEDGGAEDAGADHQQEEVTAAAHSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6X7</accession>
    <name>A0A7K2Z6X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_01980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000089">
        <property type="protein sequence ID" value="MYW28072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029658155" evidence="2">
        <location>
            <begin position="33"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="59"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="241" mass="25197" checksum="3D0C9568201A0BA9" modified="2021-04-07" version="1" fragment="single">MHRRLTRPVAALACALLAAAGALTAQQRPAAAAPEPVASVAADEFQQVTLAKGVAETGEPMTLAVLPDRSVLHTSRDGTLRLTDAAGTTKTAGKLDVYSHDEEGLQGVGVDPAFTTNRFVYLYYAPKLTTPSGDAPAGGSAADFAPFDGVNRLSRFVLRADGTLDTASVKKVLDVPASRGLCCHVGGDIDFDAQGNLYLSTGDDSNPFASDGYTPIDERANRNPAYDAQRSSGNTNDLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7B1</accession>
    <name>A0A7K2Z7B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000124">
        <property type="protein sequence ID" value="MYW28240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515632.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000124.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029844641" evidence="1">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="23233" checksum="08682D44B941BEF9" modified="2021-04-07" version="1">MHRRRRTALAVSAATLLAAPLLAACGNEAHPGAAAVVGGERIEVSAVQAQAADVRAAQESSPEAAQLVNKSGQLNRAKLHGLIFGRILDKAAEDAGVTVTRKEIQEARTAGRAQYGGEEQLRAMMLQQRWVAPDQIDGDMRQEVLLPKLAKALGADLGTPAGQQVVGEALTKASKQLKIDVNPRFGAWDDQKMQLGNYKAPWITQVTEFAPQEPEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z839</accession>
    <name>A0A7K2Z839_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000182">
        <property type="protein sequence ID" value="MYW28475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="14172" checksum="FB3CAFFFA723D3BE" modified="2021-04-07" version="1" fragment="single">RAGDHGGADLLPALAARVLDTPVTVITGEGRQQVFVPRGADPAVADTSSGPVLFAADGFFSAALPPGTTPPPATALPATSAPSSGTETAPKPPAHRSHPTPPWLPPADDTDAPRYRLDRDGVLTAPDGATFTQGPPAGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z884</accession>
    <name>A0A7K2Z884_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000203">
        <property type="protein sequence ID" value="MYW28567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045661">
        <property type="entry name" value="DUF6389"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19926">
        <property type="entry name" value="DUF6389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14613" checksum="4DDB5CE4240F91B2" modified="2021-04-07" version="1">MLDTASPDVARRLAAIRDTATERTDGVVMDVFPDQDGEGTFAVWARFEGGDAFALDRRLGDERQLLAIVHSERGWTPPVPDRPASWSTAHLGDVLFDVVAEWLDALVPPDGNGLYWEVTTPDGTQERRPVGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8B6</accession>
    <name>A0A7K2Z8B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000199">
        <property type="protein sequence ID" value="MYW28545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="406" mass="41548" checksum="DDC72C7E492CFE57" modified="2021-04-07" version="1">MSAERSPGTGRFTAPQGFLLAGSFLITLGSFAVLPYMSVLLHQRLGLGLGTVGFVLAVASLLQFAGGVVAGPVAARIGLRRSMLLALALRTAGFAAFVPGLTSPVLAIGALLLVSAGAALYLPANKAYLVDGSPDADRPRLLSASSSAFNAGMALGPPAAAPLVMGSPGVLFTCVAGLFALVGVGHAFLPREKARPETVASQEPTPGERLSRLSPFLVTVVSVYAFMFFQHYLALYAVPRTSAGFYGVVLMGYAALLVVAQPLLAEWIAALSYPAALRWGFGAMAAGMAAIAGGGHTGIAVGGALLCLGEIVLFLKNDLEALARSSAPPATVFGRQRLAAGIGAFASGVVGGQLYAAAESAGSARAFWVVVCLQCMLLPVLLMYGGRRTARGRPEPRAETASELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8D8</accession>
    <name>A0A7K2Z8D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000205">
        <property type="protein sequence ID" value="MYW28578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="172" mass="19061" checksum="E468F2AB4611E7BE" modified="2021-04-07" version="1">MSVETPRRIVLLRHAKAEWSQSSDHERPLAERGRKDAPVAGRRLADSGIDFDLALCSSAVRTRETWKLAVHEFAQRPRTVYEERLYEASLGELIALFNETPDDVRSLLVIGHNPGMHGAADALSGSAEGDTLARMTRDGFPTASYAVVEFPGSWKSVEHGAGRLTEYWTPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8E8</accession>
    <name>A0A7K2Z8E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_04935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000216">
        <property type="protein sequence ID" value="MYW28629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="390" mass="40441" checksum="C67D50B8F8977040" modified="2021-04-07" version="1">DALAARKDELAETITAELGAPLPLSQMVHAAVPVMVAASYAELVASYAFEERIGNSTVLLEPVGVVGAITPWNYPLHQIVAKVAPALAAGCTVVLKPAEDTPLTAQLFAEATEAAGLPAGVFNLVTGLGPVAGQALAEHEGVDLVSFTGSTAVGKQIGATAGAAIKRVALELGGKSANVILPGADLAKAVNVGIANVMTNSGQTCSAWTRMLVDSERYDEAVELAAQAVLRYAPGERVGPLVNAKQQARVSGYIQKGMDEGARLIAGGPSAPLPTGYYISPTVFADVTPDMTIAQEEIFGPVVSILRYEDVDDALRIANDTVYGLAGAVWAADDEEAVAFARRMDTGQVDINGGRFNPLAPFGGYKQSGVGRELGPHGLAEYLQTKSLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z928</accession>
    <name>A0A7K2Z928_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_05790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000254">
        <property type="protein sequence ID" value="MYW28795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029611494" evidence="6">
        <location>
            <begin position="38"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="7">
        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="366" mass="38828" checksum="041EAAE1CEA156AA" modified="2021-04-07" version="1" fragment="single">MDRIRSSAPGRALLTGLLATLVAVCWLAGPAAVDARAEDPVQLSRDGQITDRVGALQDRADAVEDALDRLYAERRIQLFVVYVRDFSGRSGQTWSDETANRNGLGQDDVLLSVATHDRQYAYSVDAGSELTDGQLRAVASTAIEPALRGHDWAGAAIGAADGYVSVLAGRPVTAPAITPGPADPGSGASGPSSGAGDFLLPVVVVGGAGALALFAFTRRKRRSTTRTTPAATGWGRPSEAADAPVPLEELDARAKQVLVDTDDAVRTSEEELGFATAQFGEEAAKPFTKALARAKDELTRSFRLRQQLDDAFPEDDATRRRMLEEILARCAAADEGLDAVAEDFDRLRALERDAPEALATLEPVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z952</accession>
    <name>A0A7K2Z952_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000273">
        <property type="protein sequence ID" value="MYW28867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="25"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="432" mass="46072" checksum="0DD13F1F8850D369" modified="2021-04-07" version="1" fragment="single">GREAERARLNALQSPSGDATGRAAVAVIEGTAGVGKTTLALHWAHEVRARFPDGQLYVNLRGFGHEAVMDPGEALHTFLQALGVTPTAVPADTAVASGLLRTLLADRRVLLVLDNARSADQVRPLLPTCPGSAAVVTSRNRLDGLVVREGALRLALDVLPRYAARVLLERQMGAERVALEPREADELVDLCARLPLALSVAAARTATAPVGSISALVRELRCARAPLDLFGAQDADVDLRSVFHGSYALLPAPAAHLFRLLGCHPGPEFDALTCAGLIGAPDPPLPLLDTLASAHLVHQHTPGRYTLHDLLRLYAVELLDDGPPQERVDGTERLLRHFLGTARLADHHLEPWRPTPGDPPKPTAVQPAIGDNATAADWFETELPSLQAAIARAADTPGLGAYAWRLADACAVHLRRSGRRAQRAALHALARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z972</accession>
    <name>A0A7K2Z972_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000287">
        <property type="protein sequence ID" value="MYW28887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="10398" checksum="6370B5C250E929D4" modified="2021-04-07" version="1" fragment="single">MTPRQPTTEPDARYSSALDPRPGAENVTATDWAEAERRLSGAEVFWITTVRTDGRLHVTPLMAAWYDGTLFSSTGPGGQKARDLAGNAHCALTTGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9A0</accession>
    <name>A0A7K2Z9A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ECF transporter T component CbiQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbiQ</name>
        <name evidence="6" type="ORF">GT040_06425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000297">
        <property type="protein sequence ID" value="MYW28917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23684" checksum="673B137E6323BAE3" modified="2021-04-07" version="1">RGRSPPREAMWAFGLYAALLAAVAAVAGIPPGFLLRRLVIEVPFVAFALLMPFVVPGEQTDVLGVSVSVPGLWGAWNVLAKATLGVAASVLLASTTELRAVLLGLQRLKLPPLLVQIASFMIRYGDVITDEMRRMSIARRSRGFEARGVRHWGVLATSMGALFIRSYERGERVHLAMVSRGYAGTMPVIDEVTADRTQWAYAAALPVLALAVCLLGWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9G9</accession>
    <name>A0A7K2Z9G9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">proC</name>
        <name evidence="6" type="ORF">GT040_06905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="WWKE01000309">
        <property type="protein sequence ID" value="MYW29011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="269" mass="28046" checksum="D4001058661E9293" modified="2021-04-07" version="1">MTQTVAVLGTGKIGEALLSGMIRAGWRPADLLVTVRRSERAEELHTRYGVESVSNAEAAKAADILILAVKPQDMGKLLDELAPHVSTDRLVISAAAGITTTFIEDRLTAGTPVVRVMPNTPVLVDEGMSVISAGGHATGAHLTTTEEIFGGVGKTLRVPESQQDAATALSGSGPAYFYFLVEAMTDAGILLGLPRSQAHDLIVQAAIGAAVMLRDSGEHPVKLREAVTSPAGTTISAIRELENHGVRAALIAALEAARDRSRELASGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAC4</accession>
    <name>A0A7K2ZAC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000382">
        <property type="protein sequence ID" value="MYW29279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="270" mass="28344" checksum="535C05160ED36551" modified="2021-04-07" version="1">MSTAAPSSTSVVTAPEVQDIGYGRAFADFYDRLLPHDGSAERTAEVLASWHPGGGTLELGVGTGRVAVPLARLTGEVVGVDSSPEMLQRLCETVDATGAPVTPVHGDIRTYADDSRYGLVYCVCATLSLVCDPTEQRTAVARAARQLAPGGTLVVETHNPGFVTALHEGRARTSFFIPYAEPGTGVQTYSTLIPGGLWHASHLVHGGGRVSIGTEITRLTTAEDVDSYAADAGLVLVSRQGDWAGGPFLPEGSGVHISRYRRPASGEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBH3</accession>
    <name>A0A7K2ZBH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein spdB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="30491" checksum="25B2C80737D5412D" modified="2021-04-07" version="1">MRTKAAKTVLPAVAMTAVSMVLTLAVVVMWLGTAMPWPIALVVGLGIDGGWLATLAYERRLAAQGDHSTPVTAVGWGFGLVATGVLVAHAVTADESAGAWLAVAWLPLAAKALWLVHGLWERTALTGSALEAIQGIQQEARDEAAVARARLRAEAGTEETRLTAVTQAGARVARVQAKTATTLARAWSTLESTRSGKDTGRALTSVTARVTPGVTPTWELPIWGPTNPLPALDAAPPLSDAELDRLVDEIRHSETPALSYREMSTRFRAAGHAASEFRLRAAWKRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBX5</accession>
    <name>A0A7K2ZBX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000514">
        <property type="protein sequence ID" value="MYW29861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="23220" checksum="AC22F8E9D448F6D1" modified="2021-04-07" version="1">MGAVKSKRMPRAVRERQMMDAAVQTFGQRGYRAASMDEIAELAGVSKPLVYLYLHSKEDLFSACIRREAEALVAAVRAGVDPELPADGQLWSGLRAFFTHTAENPDGWSVLHRQARSHGEPFISEVVVMRDEIVAFVTGLIGAAAREAHRDPALADRDVAGLAQALVGAAESLAGWANDTPGVSAKEAAATLMNFAWAGLENLMHARPWQAPADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBY6</accession>
    <name>A0A7K2ZBY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000497">
        <property type="protein sequence ID" value="MYW29785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="275" mass="29120" checksum="F17A6FC8C9C4555A" modified="2021-04-07" version="1">MNRRRTPRSVSAEDLLTTLQSLTARARREVELHQARVELAQALQRDMLPATLPELPGLRSAARYAPARDGLDIGGDWYDGFPLADGSLGFAIGDVQGHDVEAAAFMGQVRIAMRAIAGTVSDPGEVMGRTNDLLLSVDSGLFATCTFLRLDPHTWELHSARAGHVASVWATVDGRSGVTEDPGGLPLGIQTGEKYPVTRRTLDADGAIVLLTDGVIEGPSLLIEDGLERVRRLVAAHAGESADALADGVLGAAELTGHEDDAAVLVLRHAPARAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC31</accession>
    <name>A0A7K2ZC31_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_11355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000514">
        <property type="protein sequence ID" value="MYW29862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15229" checksum="DA3E9CCB46793558" modified="2021-04-07" version="1">GAKGEEGAKGEEGAKGEEAQAPALPAVAEWRLPGDLGRRYGAVSGDRNPIHLHPLTARLFGFPRAIAHGMWTVARCLAEADEQPGELRSVRVDFRAPVLLPATVVYAADPAGNTFVLRSESSSGSSSGRGTRSGQVHVTGSVTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC40</accession>
    <name>A0A7K2ZC40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sec-independent protein translocase TatA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_11570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000532">
        <property type="protein sequence ID" value="MYW29903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="7851" checksum="C9D6994AE19DD8F5" modified="2021-04-07" version="1">MFGIGELTILLLVIVAVLAVKRLPDLVRSAGKAARILKSEKQALKDEGKSEGGGPSQPAPRVIRGETTERDTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC97</accession>
    <name>A0A7K2ZC97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000545">
        <property type="protein sequence ID" value="MYW29932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="106"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="34962" checksum="56B1AF0C45BB1A86" modified="2021-04-07" version="1">MRGRRKASAGPLPQRDGIDAVRVRLPEDPEGRWGCVEEYLVARFGGAIGAERVAAMFDAGRFVGADGGAVRGGEPYAAGLGLWFHRDFAAEEPVPFPIGIVYRDAHLVVADKPHFLATTPRGRHITETAVARLRRELGVPSLQPAHRLDRLTAGLVLFVVRPEERGAYQTLFRDRLVSKEYEAVAPYDPGVALPRIVRSRIVKERGVLAAREEPGEANSESRVELVEACGGLGRYRLVPATGRTHQLRVHMNTLGVPILHDPLYPVVEAAGAEEDFSRPLQLLARRLEFTDPVSGEPRRFVSGLRLSAWPEGDVRGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCD2</accession>
    <name>A0A7K2ZCD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_11920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000549">
        <property type="protein sequence ID" value="MYW29972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07496">
        <property type="entry name" value="Peptidases_S8_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034176">
        <property type="entry name" value="Peptidases_S8_13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="149"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="465" mass="47470" checksum="F8BF84B8B4D021D6" modified="2021-04-07" version="1">MGTGVAFAGSSGTARPTGPAQTSAPASADSTALTQRFIVGYKSHADEATSNTAFVKDAKAKAATTGERISFERRLGTGAALVDLPDTEKPQDAQEAMAAFRADPDVAYVVPDRRVHPTAVDPAEYRYQWDLYESQAGMNVPSAWKQATGKGVTVAVIDTGITKHTELGSRLVPGYDFISDSWTATDGGGRDNDPSDTGDWANRGQCGRDRNGNPVPARDTNNSWHGTHVAGTIAATANGYGTVGVAHEANIQPIRVLGKCGGSTSDIIDAITWASGGTVSGVPANKYPAAVINMSLGGEFTCDQAYNTAIKAAVGRGTSVVVAAGNDNADASAYSPAGCANVITVAASDREGNRAAYSNYGTAVDVTAPGGETAVRADDGIWSTINKGTRSVGSEGYASYQGTSMATPHIAGLAALLKQKAPSLTPAQIEQTVKNNARSLPGSCSGGCGAGLADATKTLTAATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCJ4</accession>
    <name>A0A7K2ZCJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000584">
        <property type="protein sequence ID" value="MYW30074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="21225" checksum="546A6966B09D69F0" modified="2021-04-07" version="1" fragment="single">DAWRAGPRDAEDIAHLRATAAAMPSEGYATPLPELDPPRLPDPEALIGSFLDAVADTLPRTPAAAFALGAPFAAREPQHLPHATAWAVEVASGLDAGVRVSIRLDLSAYELFDTADTYAVTASREGPDEGAPDVPAHPDDPAVRHAAAAVVQVHSLADPTYVVDAAGLWNGLAGEPFGPRARVDTVLALRRAARVWAPLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCR5</accession>
    <name>A0A7K2ZCR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="8808" checksum="1B9D7AAF294D1267" modified="2021-04-07" version="1">MRLRVEFTTEPFDLDEAPAHAVVAREVIQSAELDAVDVGPFGNTAEGGADEVLTAVDSLLRRALASGATRVSLQVNVIGEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCX1</accession>
    <name>A0A7K2ZCX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_13130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000608">
        <property type="protein sequence ID" value="MYW30204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="62"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="123"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="358" mass="38907" checksum="3C410FD2CB1885CB" modified="2021-04-07" version="1">MTRPGSGMRPFSIKAKLGTLVVVSVFITTGLLIVALRTRTEFQFITMFSVIATLLITQFVAHGLTAPLDEMRAVARSISHGDYTRRVSGAGRRDELGDLAQTINRMADDLEAEDRHRKELVANVSHELRTPIAALRAVLENVVDGVSAADPETMRTALKQTERLGRLVETLLDLSRLDNGVVQLKASRFEVWPYLSGVLKEANLAASQRRLSSGSGNHSRTDVHLHLDVSPPELTAHADAERLHQVVANLIDNAVKHSPPHGRVTVLARRGAYPESLELEVIDEGPGIPEAERYRVFERFNRGQAPSPHGPGSDGGTGLGLAIAHWAVDLHGGRIGVAESARGCRIQVTLPGLSERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDX2</accession>
    <name>A0A7K2ZDX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000700">
        <property type="protein sequence ID" value="MYW30509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14491" checksum="3C776CB7275AD5A5" modified="2021-04-07" version="1" fragment="single">DIAGYGADARGAGTARDRDQAAQAQGDLRAQAVRDLFVRHLDHALRTLQAGLPAGVTPLRRQDFTISARGRSRVPGQGAAVALTGQIGREELGRQATIGVTSPRHAAALDALDALRRTDPALRSGPLDVDAVARRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDY9</accession>
    <name>A0A7K2ZDY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_15110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000716">
        <property type="protein sequence ID" value="MYW30571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="353"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="592" mass="62991" checksum="03050B30739C4694" modified="2021-04-07" version="1">MEHEEKQADAEEVKARARAGRAALAAMLAPVRARTRLAMGLQIVGAAATVVPYIAIAELAKALLAPGPTDEGDVRRAVLIAVFGLSVRALFGGVALAVTHFADVALQASLRRRIVERLGRAPLGWFTANSSATVRKAAQNDVHDLHYLVAHSAVETTAAVTVPVVGLGYLFWLDWRLALLALATLPLYAGAYAYMMKDFGPQMGRLDAGIAAINKAIVEFVTGIGVVKTFGRAGEAHAGYREAATRFGEHYSGWVRPMLKLEAFSSMAVSPPVVLLVNLAGGVWFVHTGWVSPVDVLTASMVALVIPSVLVTLGFGAQARREATAAAQRIAAVLETSVLPEAVHPRAPEGHAVVLEDVAFSYDGSTDVLKGVSLRLTPGTVTALVGPSGSGKSTLASLVTRFHDVTGGRITIGGADVREIASERLYRHIGFVLQDVQLLRTSVRDNIRLARPDASEEEVREAARAAQIDRRIEALPRGYDSVVGEEAVLSGGEAQRVSIARALLADAPVLVLDETTAFADPESEAAIQDAIARLVRGRTVLVIAHRLPTIVEADQIAVLSEGRIVARGRHPELLAEDGLYARMWASHERAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDZ6</accession>
    <name>A0A7K2ZDZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_15195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000718">
        <property type="protein sequence ID" value="MYW30587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512010.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000718.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="93"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="313" mass="33768" checksum="69D979C07F50BF39" modified="2021-04-07" version="1">MSTHPEIRTLPVPDGLEGERVDAAISRMFGFSRTKAAELAAAGKVQVDGSVAGKSERVHGGAWLEVEMPQAPAPVQVVAEPVEGMEIVHDDDDIVVIMKPVGVAAHPSPGWTGTTVIGGLAAAGYRISTSGAAERQGIVHRLDVGTSGLMVVAKSERAYTLLKAQFRDRIVDKKYHALVQGHPDPMSGTIDAPIGRHPNHDYKWAVTAEGKPSVTHYDLIEAYRAASLLDIKLETGRTHQIRVHMSAHRHPCVGDLTYGADPTLAKRLGLTRQWLHAVRLGFEHPSDGSWVEFSSTYPADLQHALDTIAAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE40</accession>
    <name>A0A7K2ZE40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="10" type="ORF">GT040_15200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000718">
        <property type="protein sequence ID" value="MYW30588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="20646" checksum="CA3C253E84D01682" modified="2021-04-07" version="1">MAEAERIIGTPDNPEAEHKDEGGSTAADAGVNAGTGRRKILALVGVAIVAYLLDLVSKLIVVAKLEHQPPIDIIGDWLQFRALRNPGAAFGFGEAFTVIFTIIAVGVIVVVIRLARKLYSLPWAIALGLLLGGALGNLTDRIFRAPGVFEGAVVDFIAPKHFAVFNLADSAIVCGGILIVILSFKGLDPDGTVHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEN1</accession>
    <name>A0A7K2ZEN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000764">
        <property type="protein sequence ID" value="MYW30813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="49" mass="5180" checksum="AA43E7ABC51FFDDA" modified="2021-04-07" version="1" fragment="single">MGFTIGGIREKRSGVRRRGRGAEATAVAEYTGLWGWAVAPGTRARDGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZES2</accession>
    <name>A0A7K2ZES2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="170"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="30162" checksum="D99785687CD49F14" modified="2021-04-07" version="1">MTVHPSLQTYADSATHSIEAIADLVKPLAEGEWNRRTPCPGWSVRDIVSHVIGMECEMLGDPRPIHTLPRDLYHVQSDFARYMEMQVDVRRHHTAPEMTSELEYVLIRRARQLRNESRSPETTVRAPLGAEQTLEVALNMRAFDVWVHEQDLRTTLGQPGNLDSPGAHITRDVLLAALPKVVAKDAGAPANSAVVLDVHGPVEFLRTVRVDAEGRGSIDGSPSLGPAVTLSMDWETYVRLACGRVRPAAVADRIKAEGDQELATAILDNFAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEV0</accession>
    <name>A0A7K2ZEV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_16590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029631469" evidence="9">
        <location>
            <begin position="37"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="40"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW30848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="31648" checksum="1BEBF08728D94ADB" modified="2021-04-07" version="1">MKIGIKRINRVTITSTVALTAGAVLASGAFASTAQAAAAPPAPKIVAKGGFVMNSGTGKSLFSKAADTRRSTGSTTKIMTALVVLQQKNVNLKTKVTIQKAYSDYIVSKNASSARLIVGDKVTVGQLLYGLMLPSGCDAAYALADKFGTGSTRAARVKSFIGKMNATAKSLKLKNTNFDSFDGISSGKNYSTPRDLTIIARQAMKNATFRSVVKAKSTKQKVTTKSGGYRYMSWTNTNKMLSSYSGAIGVKTGSGPTAKYCLVFAATRNGKTVIGTVLTSTNETTRTADAKKLMDYGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF07</accession>
    <name>A0A7K2ZF07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1003 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000805">
        <property type="protein sequence ID" value="MYW30940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="187" mass="21970" checksum="8831B8BDE27D8277" modified="2021-04-07" version="1">MAEREERSKAASTGASGLMRPPRTRIDQPKSPRRRLLPEYDPEAFGRFSERIARFLGTGRFIVWMTLIIIVWVAWNVWAPKELRWDEYPFIFLTLMLSLQASYAAPLILLAQNRQDDRDRVTHEQDRKQNERSIADTEYLSREIAALRMGLGEVATRDWIRSELQDMVRDMEDRRILLTSESDEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFD5</accession>
    <name>A0A7K2ZFD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">dapD</name>
        <name evidence="6" type="ORF">GT040_17415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000814">
        <property type="protein sequence ID" value="MYW31009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_M" evidence="5">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="304"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="332" mass="34227" checksum="FFB8177C78C9EA12" modified="2021-04-07" version="1">MTDTTSQATSRTTGAVAAGLATVAGDGTVLDTWFPAPELKPEPGPAGTQRLTPDEAVNRLGEGAAKAIGVDARRGVEVVAVSTVISSLEDKPLDAHDAYLRLHLLSHRLVQPHGQNLDGVFGLLANVAWTSLGPVAVDDLERVRLNARAEGLHLQVTSVDKFPRMTDYVAPKGVRIADADRVRLGAHLAAGTTVMHEGFVNFNAGTLGTSMVEGRISAGVVVGDGSDIGGGASTMGTLSGGGNVRIVIGERCLVGAEAGVGIALGDECVVEAGLYVTAGTRVTLPDGQVVKARELSGASNILFRRNSVTGTVEARPNNAVWGGLNEVLHAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFI1</accession>
    <name>A0A7K2ZFI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000855">
        <property type="protein sequence ID" value="MYW31111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8844" checksum="256FC9CA1C3FCFDB" modified="2021-04-07" version="1">MAKVHERGKEPVDEDHAVLRTGADRTLPRPGRKPGPVPLVPQQPYLSDEFRYHRRRQARDPPVADNRCARRVPTTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFN9</accession>
    <name>A0A7K2ZFN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-lysine 6-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000857">
        <property type="protein sequence ID" value="MYW31138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016641">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001695">
        <property type="entry name" value="Lysyl_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01186">
        <property type="entry name" value="Lysyl_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029811866" evidence="2">
        <location>
            <begin position="33"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="609" mass="64278" checksum="7ADDF28705566A81" modified="2021-04-07" version="1">MTRSQQSRTSRLTRPSVAIAAAVAVTAGVVAAAPDAKTAAVAGPKLSLIAASKSVTLDSWKEDPGVYLDLGTYLTSEKGAFEFKVTRKSYKDPVVASQIIRNGKKTTTKALPAGLVKDFTGLPNFMEVSVVDAAGKSVLKKTESFCPNNASGRVRPDAPANSRYPQSCPVNPFTLGSVWGVENGWAANTYAGYYSAPVQLAAGTYTAKISVTKKYRDLFGIANKPQSVKVTVRERSWEEEEGGSGGAAAKVAPRSLHAGHAGHQAAAGHAGHQAAADPAPSGHAGHGAPVRTDAPATATTGAGATFNVGHGPYPPAPPALPWALKKQAAEKQAGKDAFGAQGFSAARVGDRAGQTDGSRQAPGAQPNAKRPTGKAAVPDVPKPDLRSLPAYGITVSDGYEDVPGKDYLAFSANVWNAGPAKLVVDGFRSPGKELMDAYQYFYDAKGKQVGYTPTGTMEWDPRPGHEHWHFTDFASYRLLKADKKETVRSGKEAFCLANTDAVDYTVKNANWHPGNTDLSTACGQENSISVREVLDVGSGDTYTQDLPGQSFDITNLPNGTYYIQVLANPENRLKETNHKNNSALRKVVLGGKKGARTVKVPAHHLVNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFP1</accession>
    <name>A0A7K2ZFP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029456925" evidence="1">
        <location>
            <begin position="25"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="18140" checksum="0911A74FD57DAB4D" modified="2021-04-07" version="1">MARATTRNPLVIAATALAVVAAGAAGWGGWQRYDAAHDDAASYAQARDDALAAGEQAVQNMNTLDHRTLAKGLDSWEESTTGDLHRQLLDGRDAFAKQIVAAKTVSTAKVLSGAVTELDERAGRAGVMVALRVTVTAPKGDPAVKESRMLGTLTRTSEGWKLSALGQAPVGSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFT8</accession>
    <name>A0A7K2ZFT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000863">
        <property type="protein sequence ID" value="MYW31202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076967167.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000863.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="12004" checksum="AF65F3ECA21A3C76" modified="2021-04-07" version="1">MPPETPSHAIDRLDDDDYPAYTMGRAAEMIGATPGFLRAIGEARLITPLRSEGGHRRYSRYQLRIAARARELVDAGTPVEAACRIVILEDQLEEALRLNEELRGGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG29</accession>
    <name>A0A7K2ZG29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000877">
        <property type="protein sequence ID" value="MYW31286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6310" checksum="7741EFD15DA42F55" modified="2021-04-07" version="1">MPASRERVPDLPLVAASPPGPVTSEDRSRLGCPSCGSSHVAQVLGDNGGVSYVCTACGHSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG35</accession>
    <name>A0A7K2ZG35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000892">
        <property type="protein sequence ID" value="MYW31323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029909474" evidence="2">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylas" evidence="3">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="7718" checksum="117C05C0D39D6BD3" modified="2021-04-07" version="1" fragment="single">MLLNSKGKHRRPSKTIRFATLAGITGAAVAVPLMGATNASAASVSTWDAVAQCESGGNWSINTGNGYYGGLQFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGI7</accession>
    <name>A0A7K2ZGI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000922">
        <property type="protein sequence ID" value="MYW31452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029505241" evidence="1">
        <location>
            <begin position="26"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="58"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="27451" checksum="29A52A653DC7EB82" modified="2021-04-07" version="1">MSKKMTLFGGGLAAALVTTLTLALSGCSMETTAPGSARQDAASDAKGSFGRADCRKAKCIALTFDAGPGKDTPELLDILKEKKVHATFFLLGKHHVLKHPDTVRRIQDEGHEVANHTWTHKILTDEEPDAIRAELEKTQVAIEKVTGTKPRLMRPPQGRTDDKVSGISKELGLSQVLWSATAKDYSTNDSALITKRIVDQASKDGIILLHDIYQGTVPAVPGIIDTLQKDGYTFVTVPELMAPAVPEPGTIYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGL3</accession>
    <name>A0A7K2ZGL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pepN</name>
        <name evidence="16" type="ORF">GT040_19910</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000928">
        <property type="protein sequence ID" value="MYW31480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="90"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="223"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="535"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW31480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="714" mass="78112" checksum="39FD61F23F4D579D" modified="2021-04-07" version="1" fragment="single">MSVLTRDEAQTRAQIIDVERYTIALDLTTGEETFDSRAAIRFTARAAGDTFIEIKPATLRSIALDGQPLDPALLDGNRYPLTGLTPGPHELHVDAAMSYSRTGEGMHRFTDPADGETYLYTQLFLEDVQRVFAAFDQPDLKSVFAIDVTAPAGWTVLGNGVAERTGDGRWTVAPTPLISTYLVAVAAGPWHSVTTEHAGLPFGLHCRRSLAPYLDADADEILGITRACFDRYHEKFDEPYPFDSYDQAFVPEFNAGAMENPGLVTFRDEYVFRSAVTDTERQSRAVTIAHEMAHMWFGDLVTLSWWDDIWLNESFAEYMGYQTLTEATGPQALNSVRAGETLFPDTWVDFGVARKGWGYDADQRPSTHPVAPDPEAVPDTASALLNFDGISYAKGASALRQLVAWLGEKDFLAGINTHFARHKFANATLADFIDNLASATDRDVHAWAEQWLRTTGVDTLTADVHEPTAPTEAGQSWALAVDRAGSRPHRITVSTFDHALNTQAGPGHLAPRDRFALDIPGDGTPLVRPGRRPALVVLNDGDLTYAKIRLDAASWETALGHLSAIPDALTRAVIWNAARDMVRDGELDPTRYLTAARTHLPYESDLALVQGVLSFAGGQIAARYATPEARPAALATLTSLCRDLIRRTEDGSHPGLRLTAVRHFIDAATQPDTLQSWLTEGTVHGGPELDPELRWRILTRLAALGATDEAAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGM0</accession>
    <name>A0A7K2ZGM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000923">
        <property type="protein sequence ID" value="MYW31455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="1">
        <location>
            <begin position="76"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="341" mass="36485" checksum="D35CEACF313B0BC6" modified="2021-04-07" version="1">MTSAPVLPATLWFTRCPVPTATGIAADRQWLTDEFAPDGITVRSLQDAEPDADREAHFTHALPGLFREGGNVPALWARSRGERTRLIGLTWIEERQVVLVAPGSGIRSAGDLRGRRIALPVHPIAIDFWRAMALRGFEGVLASAGLGLADTVPVDVPADGHPGQWAAELAALRRGDVDAVYVKGALAVEAARRSGAEVAVELDDLPDRRFRINNGTPRPITVHQDLLDEHPALVDRFLAVLLRAADWAAKSPAEVDRILGAETGAGAEGVAGAYRPGTHLTLHPDLSTERLALLAEQESALRAHGFLPDPVAVSAWADPEPLRRAAELNDAHPKSPLPVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGS7</accession>
    <name>A0A7K2ZGS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000936">
        <property type="protein sequence ID" value="MYW31515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="256" mass="27492" checksum="7F65F390DB1913CE" modified="2021-04-07" version="1">MPQEQQRYRERPSRLPGAVVWTWDAPDHLPREPRSVLPDGCMDLIWTGGRIVVAGPDTHAFQVEPRNRASCAAIRLAPGTAPVLLGVPAHELRDHRADLADLWPSSTVRRLTDRIDEASDPAEALERFALDRIADTGPPDLRTVAVAEGLRRGRTVAAMAAEAGLGARQLHRRSLAAFGYGPKTLARILRLQRALELIRTGLPYAEAACAAGCTDQAHLAREMRDLAGTTLGAYFGAGGADANSETPQPSGSSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGV4</accession>
    <name>A0A7K2ZGV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydropyrimidinase</fullName>
            <ecNumber evidence="4">3.5.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hydA</name>
        <name evidence="4" type="ORF">GT040_20495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="2">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000968">
        <property type="protein sequence ID" value="MYW31591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="55"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="466" mass="50477" checksum="0F6AB0015F81B0F1" modified="2021-04-07" version="1">MSRTVIRGGLVITASDEIHADVLVEGGRIAALAAHGTDAADSWSADRTIDATGKYVIPGGVDGHTHMEMPFGGTYAADTFETGTRAAAWGGTTTIVDFAIQSVGKSLREGLDAWYAKADGNCAIDYAFHMILADVNPSSLKEMDRLVAEGVTSFKLFMAYPGVFYSDDGQILRAMQQASGNGGLIMMHAENGIAIDVLVEQALASGRTDPRYHGDVRKVALEAEATHRAIQLARVAGSPLYVVHVSADEAVEEIAAARHKGLPVFGETCPQYLFLSTDNLAEPDFEGAKYVCSTPLRPKGHQETLWRGLRNNELQVVSTDHCPFCFSGQKEMGRGDFSKIPNGMPGVEHRMDLLHQAVVDGHITRRRWIEIACASPARMFGLYPKKGTIAPGADADIVIYDPQAEQTLSAETHHMNVDYSAYEGKRITGQVETVLSRGELVVDSRKFTGRAGHGMYTPRATSQYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH43</accession>
    <name>A0A7K2ZH43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nickel-type superoxide dismutase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sodX</name>
        <name evidence="3" type="ORF">GT040_20970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000984">
        <property type="protein sequence ID" value="MYW31683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014124">
        <property type="entry name" value="Pept_S26A_Sod_Ni_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02754">
        <property type="entry name" value="sod_Ni_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="2">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18647" checksum="EE1FEEACBFE6F7DF" modified="2021-04-07" version="1">MYGAERGTRDGVPEEDREVAEVPEWGRVSGGGRAGRRRPLRVVEVTGPSMVPTLYHGDLLLVQYGALVSPGDVVILRHPFQQDLLVVKRAVERRPGGWWVRGDNTFAGGDSTDYGVVPEELVLARVRARYRPLPKGPTSAKGQRSVTELLGWAVSAVRPVRSASARLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHP8</accession>
    <name>A0A7K2ZHP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YihY/virulence factor BrkB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_21910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001029">
        <property type="protein sequence ID" value="MYW31857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="315" mass="32845" checksum="18271316F6F41D26" modified="2021-04-07" version="1">MDWLKKLPVVGPLVSRLMETHAWRSYERLEKVHWARLAAAITFISFLALFPLIAVGAAIAAALLSDKQLDTIKDKLAEQVPGISDQLGIDTLVANAGTVGLVAGALLLFTGVGWIGSMRECLRAVWELDDVQEANPVVAKLKDAVLLVGLGGAALATLAVSTVGTTAVGWSADRLGISHGGVGGILLQIAALAVAVLADFLLILYLLSLLPGVEPPRRRLVVAALIGAVGFELLKLLLGSYMKGVAGKSMYGAFGVPIALLLWINFSAKLLLFCASWTATGSKEEELGEDRAEDAPETGTGDTAGAVAPGGSTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHU0</accession>
    <name>A0A7K2ZHU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_22260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001060">
        <property type="protein sequence ID" value="MYW31923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029741370" evidence="2">
        <location>
            <begin position="20"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="82"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="543" mass="59263" checksum="71F4D0922AA61743" modified="2021-04-07" version="1">MRGATRTRWAACAVAVALAATACGGGGDDSGGSGADGIVSSSWGDPQNPLEPANTNEVQGGKVLDMVFRGLIRYDPKTGEAQNMLAESIDSDDAQNFTIKIKDGWTFSNGEKITAKSFVDAWNYGAALKNNQKNAYFFQYIEGYDKVHPESGSASAESLSGLKVVDDLTFTAKLSQKFSLWPDTLGYAAFAPLPKAFYDDHDAWLSKPVGNGPYTIESYAKGSSMNLRKWDDYPGDDKAKNGGVDLKVFTDNNTAYTSLTSGNLDLVDDVPASQLRNVEQDLGDRYINTPAGIIQTISFPFYDKEWDTDNARKVRQGLSMAINRKQITDQIFQKTRTPASDWTSPVLGEDGGFKKGLCGKECTYDKAEAKKLIDEGGGIPGGQLKISYNADTGSHKEWVDAVCNSINNVMGNNQACVGGAIGTFADFRSQVSTQKMTGPWRAGWQMDYPLIQNFLQPLYYTNAPSNDGKWTNKDFDDLVDKANAETDKAKAITTFQDAEKVLVEQMPSIPLWYQNGSAGYSERVSNVELNPFSVPVYTEITVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHV0</accession>
    <name>A0A7K2ZHV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="31"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="351" mass="37883" checksum="24144120B18EDD1E" modified="2021-04-07" version="1">MTQVTQVAHVADHGGGVHSIKVPIPDNPLGHTLVHLVDTDRGPVLIDTGWDDPASWDTLVAGLTALSTAVTDVHGVVITHHHPDHHGLSGQVREASGAWIAMHEADAAIVRRTREAAPGTWLDYLARKLAAVGAPDDHLAPLLAARSSGRLRTLPGLRPALPDREIVPGELLPLAGRRLRAVWTPGHTPGHVCLHLEERHPANLPGHGRLFSGDHLLPGISPHIGLYEDPDDTAVTDPLGDYLASLERIGRLGVAEVLPAHQHAFTDAGGRVRELLDHHEERLTGLLALLATPLTPWQLAERMEWNRPWEQIPHGSRSIAVSEAESHLRRLVKLGRAEAVPGADPVTYIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI06</accession>
    <name>A0A7K2ZI06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001064">
        <property type="protein sequence ID" value="MYW31992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016291">
        <property type="entry name" value="Isochorismatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001111">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01398">
        <property type="entry name" value="ISCHRISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22756" checksum="D82C843A3C61FD53" modified="2021-04-07" version="1">MALPAITPYPMPAADELPANRVDWTVDPARAVLLVHDLQNYFLSAYDRQAAPVPELLSHVAELKKEAARLGVPVLYTAQPGGQSAEERGLQQDFWGPGLPADEHAAAIADEVAPGDGDTVITKWKYSGFVRTDLLERLREQGRDQIVLTGVYAHIGVLMTACDAWMQDIQAFVVADAVADFSADDHAMALRWAAGKCAVVTTTRAVFEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJD0</accession>
    <name>A0A7K2ZJD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001181">
        <property type="protein sequence ID" value="MYW32470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="27267" checksum="4F95244690789CE9" modified="2021-04-07" version="1" fragment="single">MSNPQGADTAGEPGARGRPARGAATPAPATRAVELRHLRAFLAVADEGNVTRAAAHLGLTQPAVSRTLAALERHLGIRLVDRSTHHLALTPEGVAFRDKAAAAVAAFDEALDTGRLRHWPLRLGHAWSAFGPYTTPLLRGWQERYPATPLELLRIDDRTAGLTRGEVDAALLRGPVEAPGLVTEVLFTEARVAAVTADGPLASRTSLRLADLAGGPVVLNTVSGTTTPALWQPEARPAATLTVANTDDWLTAIAAGRGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJM4</accession>
    <name>A0A7K2ZJM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="29584" checksum="CB06CF6370E6B1AC" modified="2021-04-07" version="1">MTTTQVPARDTLESIASRIRSHVVDMCAGPEGGHLGGAFSCVEVLSALYFSVLNVDPRHPDDPDRDRFLLSKGHAAVALYATLAERGFIPVGELAEYGRPGSRLMGHPVRAVPGVEMPTGSLGHGLALACGFALANRYAGRDARSFVLLGDGELQEGSVWEAAIAAASLRLDRLVAVVDRNGLQLTGSTERIAPMEPLAERWRSFGWAVRDVDGHDADGLAGHLAAAPWEPGRPSVLIARTVKGQGLPFLAGRAASHYVTLSERNHARALGALRTTGGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJU2</accession>
    <name>A0A7K2ZJU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_25855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001202">
        <property type="protein sequence ID" value="MYW32603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="385" mass="42519" checksum="5ABB4FA1753C3C8F" modified="2021-04-07" version="1">MDLAYTEAEEEFRGRLREWLAGVLPGLPPKPSPDDWPARRAYDTTWQRMLYDAGYAGLHWPADVGGRGATPTQHLIFLEEAERAGAPYVGANFVGLLHAGPTIAAEGTAEQRARWLPPVLRGDEIWCQGFSEPDAGSDLAALRTRAVRDGDDYVVSGQKIWTSHAEVADWCELLVRTDPGAPKHRGISWLAMPMDAPGITVRPLRTLAGSTEFAEVFLDEVRVPVRNRVGAENDGWRVTMVTLSYERGTAFVGEVVACRRTLEALAAEARRNGRWDDPVLRRRLGRLNAEFRALWRLTQANVSESERTGGVPGIGGSVFKLRYSGVRQELYEAAAEVLGGIDAFDLDREWALDRLSSLSYTIAAGTSQIQRNIVAERILGLPKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJV2</accession>
    <name>A0A7K2ZJV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001207">
        <property type="protein sequence ID" value="MYW32630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="30176" checksum="D5944AB56F2A0E58" modified="2021-04-07" version="1">MTHTHTHDHHGEAEILDLDAQVLADHLTALTGWLPVQAPPRRIVDLGCGTGTGTFALLDRFPEAHITAVDTSAAHLQRLREKACARGAEGRVRTVQADLDAVGWPDLGTPDLVWASASMHHMADPDRALKAVHDLLAPGGLFAVVELSGFPRFLPAGAPEDRPGLEERCHEASDRFHAEHVPHRGADWGPKLTGAGFTVEDERSITVDIGTTDGSRSEAVGAYALGSLRRLRHSVAGTLAPEDLAALDRLLDTEGPGSLLRRDDLTVRTERTVWAARRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJX9</accession>
    <name>A0A7K2ZJX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANTAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001198">
        <property type="protein sequence ID" value="MYW32559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="164"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="25442" checksum="0997CB1E20E0C6EE" modified="2021-04-07" version="1">MTDGLTPGTPDLVSLLLDSDTLDEFLQVLAESALAQAPGADGCGITLERQHRPLTVVSAGISAPALDEAQYGQDDGPCLEALREGHEVSVGDMQLENRWNGYPAFAVAAGTRSSFSLPIAAHSHTAGALNLYSPKVDGFEEADLGALRDLAAQATGAIALAQRLSDTQTFTADLQAALTSRTVIDQAAGIIMNQRRCTAEEALATLRSASQHRNVKLRDLCAQLVGSISGSMPPGGPQVRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJZ0</accession>
    <name>A0A7K2ZJZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="17221" checksum="4433052DE3E9CBD8" modified="2021-04-07" version="1">MSRLGAPRRATAAQLASLALLGDVGRPATLTVGDLRDGWRQHRAEVVFDCATSGPQRHVFEGPLLREVALTSQPLFDALRRKDRSRFALAVSGGDGHHTVLAWAEIDADFGNAPVLLATRLDGEDLDVAGSQLVVPVDRCGARYISAITRVWVGAWPGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJZ7</accession>
    <name>A0A7K2ZJZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_26185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001217">
        <property type="protein sequence ID" value="MYW32667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029680537" evidence="2">
        <location>
            <begin position="33"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="272"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="362" mass="36324" checksum="45E9655499C09BCF" modified="2021-04-07" version="1">MDASPSRRSARRLLPLIAGVCAIALAAGCSGAEPAASPAPEASPSGTAQGSVTRDSAELENAYKAVINDVLPSVVQIDASDSLGSGIVYDDKGHIVTNAHVIGDEKTFKVTVATGEAVLNASLVSSYPEQDLAVIKLDDVPDGLKPAKFGDAEKVEVGQIVMAMGSPLGLSSSVTQGIVSALGRTVSESRAGGGTGATIANMVQTSAAINPGNSGGALVNLSSEVIGIPTLAATDPQMGDSAAPGIGFAIPVSMVRTVADQIIKDGRVTDSGRAALNITGRTVVDDSYRPAGVALVSVERDGAAGEAGLRAGDIITKIGDTAVTTITSLSEALAGDQPGDKVTVTYTRDGDSRTAEVTLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK94</accession>
    <name>A0A7K2ZK94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001250">
        <property type="protein sequence ID" value="MYW32774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="296" mass="30950" checksum="D054F4E1A25A7172" modified="2021-04-07" version="1">MIEARHLRVLRAVATTGSFSAAARELGCTQPAVSQQMKALESSAGTTLLIRTGREMRLTQAGEALVRHASGILAGLTAAEEEVAAIAGLRAGRVRLVSFPSGSSTLVPGALAALRAEHPGTRVSLVEAEPPRSVDLLRDGDCDIALAFRYGTTGGEWDDLVVRPLLTDRLIGLVPDGHRLADAEGVSIGELADESWIAGCPRCRRQLVEVCEASGFTPRIDFATDDYPAVMGLVGAGLGVAVLPELAVESVRPKGARTVAVEPAIEREIVALTLPDLARVPAVAATLDQLSLAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKD8</accession>
    <name>A0A7K2ZKD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">dnaA</name>
        <name evidence="14" type="ORF">GT040_26965</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001255">
        <property type="protein sequence ID" value="MYW32816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="44"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="13">
        <location>
            <begin position="258"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW32816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="351" mass="39241" checksum="02F2119177B56C35" modified="2021-04-07" version="1">PAPGPGEPHARLNPKYLFDTFVIGASNRFAHAAAVAVAEAPAKAYNPLFIYGESGLGKTHLLHAIGHYARSLYPGTRVRYVSSEEFTNEFINSIRDGKGDTFRKRYRDVDILLVDDIQFLASKESTQEEFFHTFNTLHNANKQIVLSSDRPPKQLVTLEDRLRNRFEWGLTTDVQPPELETRIAILRKKAVQEQLNAPPEVLEFIASRISRNIRELEGALIRVTAFASLNRQPVDLGLTEIVLKDLIPGGEESAPEITAPAIMAATADYFGLTVEDLCGSSRSRVLVTARQIAMYLCRELTDLSLPKIGAQFGGRDHTTVMHADRKIRALMAERRSIYNQVTELTNRIKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKI8</accession>
    <name>A0A7K2ZKI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Keto-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="1">4.1.2.14</ecNumber>
            <ecNumber evidence="1">4.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="1"/>
    <dbReference type="EC" id="4.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001266">
        <property type="protein sequence ID" value="MYW32866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="51" mass="4868" checksum="B21E1E20ACAFE08A" modified="2021-04-07" version="1" fragment="single">MTSSPASPPPAAPSDTSALDLAPVVPVVVLHDAADAVPLARALVAGGLPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKL6</accession>
    <name>A0A7K2ZKL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_27360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001273">
        <property type="protein sequence ID" value="MYW32892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="224" mass="24221" checksum="A32BFB04EB8731B3" modified="2021-04-07" version="1">MAIRVMLVDDQVLLRTGFRMVLAAQPDMEVVAEAGDGAEAIEILRATAVDVVLMDVRMPRLDGVEATRRICAQPNPPKVLILTTFDLDEYAFSGLKAGASGFMLKDVPPAELLSAIRSVHSGDAVVAPSTTRRLLDRFSPMLPSSEKEPKNKHIQKLTEREREVMLLVAQGLSNGEIAARLVLSEATVKTHVGRILTKLSLRDRVQVVVLAYETGLVRAGGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL75</accession>
    <name>A0A7K2ZL75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001319">
        <property type="protein sequence ID" value="MYW33107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="2">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="235" mass="25202" checksum="68EF89A1949B5563" modified="2021-04-07" version="1" fragment="single">MNRQNGAARPLDVVLFGATGFVGVLTAEYLAAHAPEGLRWGLAGRSRAKLEQLRERLAAIEPECAGLPLLETDADDEDALRELAESARVVATTVGPYILYGEKLVAACAEAGTDYLDLTGEAEFIDRTYVRHDARARETGARIVHACGFDSVPHDLGTYFTVKQLPEGVPLTVDGFVRSNAVFSGGTFASALTAMGRGPQMLLAARERRLHEPRQVGRRVRTPAGTPHFSGATGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLH7</accession>
    <name>A0A7K2ZLH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3043 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001354">
        <property type="protein sequence ID" value="MYW33217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="38" mass="4292" checksum="628CCEC578D63A9B" modified="2021-04-07" version="1" fragment="single">MFRSRAKTEKAPTDKVTADLSQQPRDPQAPKGRPTPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLR2</accession>
    <name>A0A7K2ZLR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CocE/NonD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001366">
        <property type="protein sequence ID" value="MYW33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="291"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="664" mass="74772" checksum="B401A87188FCD16D" modified="2021-04-07" version="1">MNITTEFPYETTREDVYIPLPGGTRLYARIWRPLTDEPVPALLEYLPYRLGDWTAPRDWQRHPWYAGHGYASVRVDVRGHGNSEGLPGDEYDAQELTDGVAVIHWLAQQEWCSGRVGMFGISWGGFNSLQIAALAPEPLKAIVTVCSADDRYDNDVHYMGGSVLAVDMHAWAATMLAFVSRPPDPAQIGDDWKEMWLKRLEAVEPPIHTWLAHQSRDDYWKHGSVCEDYGAIKANVLAVGGWHDPYRDTVLRLVEHLDPGQVRGIIGPWSHQYPDRGLPPGPAIGFLQETLRWWDQHLKGKETGVMREPLLRSWISGSHPPATVYETLPGRWVGDASWPSENISPVAYALQGGERIVASPQQTGLDAGRFFPFGNEADLPPDQRDEDAKSVSFEFPVEEAPIEILGRPRVKLRLRMDVPRGQAIARLCDVAPDGSSTLVTRGVLNLAARHGRERTDDWTPGDTEDVVFDLNGIGHTFPPGHRIRIAISSSYWPWIWPQAGSAGFTLDADGSFVELPVRRHTEDPAITFGEPEQSEPLGVVYPVTLEEPRPERLVVRDVAKGEWRLEVDPRYGGTRVYPDGLEFTEDALETYTIQQDDPLSARTRSDWRIRLHRPEMSWDVEVETRSEIAADDNDFITSNEVICKDGGEVVFHRTWEKRIPRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLU2</accession>
    <name>A0A7K2ZLU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AfsR/SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001378">
        <property type="protein sequence ID" value="MYW33335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="BTAD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="24048" checksum="6B2547F3DFCEBDB7" modified="2021-04-07" version="1" fragment="single">AVWRGPAFADFADEEFARTARDRLDEQRLTALEEQAEVRLELGEHALVADELGDLVALHPLRERLRAAQVRALYLAGRQAAALGSYAELREQLAENLGVDPGPGLEALHRSILGQDPRLTAAPSPATSAVRPATNIPAALTELIGRSGAMDQLRTLLAANRLVTLTGAGGVGKTRLALAMASEVVDRFPGGVRLAEFAVLDPTPVPAGRAGAAASPAGVHEVVGAVLGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLZ2</accession>
    <name>A0A7K2ZLZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="26939" checksum="00B0FB3F27A64B5A" modified="2021-04-07" version="1">MSDPVNSTILLLDIERYSDRDDVEQSYLRRMLFGLTDRVLLAAGIEETLRRRADRGDSVMELIDANASLTALLRSLLAVVPAELHALNRLASSSARMRLRCVVTSGYVAVDPDGGWVGSDLNHACRLLDADVLRNELKKSSGDFALCVSEPVYSGVVRHNHLGVVAEEFHAVTVESKNGDLPARVHRPYSRAEPSEPMAGPRAADRPSGPVPPGAAGFPAGTVQGGVFGGSNHGIGGGIFHGDVHIGGASGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM25</accession>
    <name>A0A7K2ZM25_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-ribose pyranase</fullName>
            <ecNumber evidence="2 5">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rbsD</name>
        <name evidence="6" type="ORF">GT040_30150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodecamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RbsD / FucU family. RbsD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2 5"/>
    <dbReference type="EMBL" id="WWKE01001391">
        <property type="protein sequence ID" value="MYW33414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01661">
        <property type="entry name" value="D_rib_pyranase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023064">
        <property type="entry name" value="D-ribose_pyranase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37831">
        <property type="entry name" value="PTHR37831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="13798" checksum="8DBBCD8459F7CB2B" modified="2021-04-07" version="1">MKKSGILNRHLAGAIAELGHGETVLICDAGMPIPPGPRVVDLAFRAGTPSFAEVLDGLLDELVVEGATAALEVRDANPEATRLLDDRFPDLELIPHDDLKARTASARLVVRTGEARPYANALLRCGVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMD9</accession>
    <name>A0A7K2ZMD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001399">
        <property type="protein sequence ID" value="MYW33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="6"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="20880" checksum="5BC6488FEFCAD14B" modified="2021-04-07" version="1">MGLMNIMLFHSTYGLTPAVHAAAARLRDAGHEVRVPDLFEGHTFDTVEEGMAFKEELGKEELLKRAVLAAAPYSDQGLVYAGFSLGAATAQTLALGDAKARGLLLLHGTSDIAGNATVDELPVQLHVADPDPFESHDWLNSWYLQMQRTGADVEIYRYPGAGHLFTDPDLHDYDQAAAEQTWKVALGFLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMF3</accession>
    <name>A0A7K2ZMF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF393 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001396">
        <property type="protein sequence ID" value="MYW33449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="143" mass="15472" checksum="FAAC5E0CE44BCFB6" modified="2021-04-07" version="1">MSPVTAAAPVRRLTVLYDAQCPLCTHLRHWLGRQRQLVPLDLVPAGSAEARRRFPELDPAATYAEITVVGDLGQVYQGTSAWIVCLWALAKYRSKAHWLTTPAGAPFARGTVLAAARYRAATAARCGPQQACPVPPGGQWAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMX8</accession>
    <name>A0A7K2ZMX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001445">
        <property type="protein sequence ID" value="MYW33713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="8208" checksum="9DAE59F635AA9128" modified="2021-04-07" version="1">PFQGGRVTGRIPRTATLRPTVVPLEWERMGDPPTRRPVRELGNGPTDLALLASALERAARSVNAERLPPLIPFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMY7</accession>
    <name>A0A7K2ZMY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="456" mass="50062" checksum="CC35AFA191399D0B" modified="2021-04-07" version="1">MTTSAPNQRLRDLISESGLTYEALAKAVRQVAAECGVELATNKGMIRHWLNGVVPQETTARFLAAALSRHLGRLLRPTDLGLPVPDGAEDDSMGLSLGADPIDALVPMWRAELDRRTFLTSSAYSVAAAALPLDYVQEVADRSAAARTGHIVGMAEVRAVRDMVRMFSEMDERHGGRHGRSALVQHLRDDVAPLCRARFHNEEMRRHMLSAASRGVHLLGWKSYDAGQQGLAQRYYLQSYALAVESGITGQDGFIMRTMAMQGLKLHRPEHCQGLAETGLNRAKGKVDNATMALFRVVHAHTLAKSGQRRAAVVEADRARELLATDKGDETPFWALAWGPPAASVYSRTAKVHETLGDFSAAAGQYARAATARPSTTYARIVSLDLVAGAEMQLKRGRIEEACETWNRAIDHMDGVQSARTRKAVKNMRKDLARFRARGVRCAAELDERALDFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN05</accession>
    <name>A0A7K2ZN05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2191 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001448">
        <property type="protein sequence ID" value="MYW33727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513508.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001448.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="7129" checksum="555C66B7E6BFA6DB" modified="2021-04-07" version="1">MAKVSVSLDAELVVEVMVLAGVGSPQDAVELVVRDYIARGHRTEALVAEREESVRDVEPKPQAQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN21</accession>
    <name>A0A7K2ZN21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 12">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpE</name>
        <name evidence="15" type="ORF">GT040_31935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 12"/>
    <dbReference type="EMBL" id="WWKE01001453">
        <property type="protein sequence ID" value="MYW33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="14">
        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="13">
        <location>
            <begin position="228"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="497" mass="53915" checksum="0785DE113B965933" modified="2021-04-07" version="1">MDLDTFRKLAVDRRVVPVSRRLLADGDTPVGLYRKLAAERPGTFLLESAENGRTWSRYSFIGVRSDATLTARDGTAHWLGTPPVGVPVDGDPLEALRATVETLHTPRDLVSDAGLPPFTGGMVGYLGYDVVRRLEKIGEHGGDDLKLPELTMLLTSDLAVLDHQNGTVLLIANAINHNDLSTGVDEAHADAVARLDAMEQDLRRPVENAPAVLPPSELPPYTALWGGEAYQEAVEDIKERIRAGEAFQVVPSQRFETPCSASALDVYRVLRATNPSPYMYLFRFDGFDVVGSSPEALVKVEDGRAMVHPIAGTRHRGATPQEDQALAEELLADPKERAEHLMLVDLGRNDLGRVCEPGSVEVVDFMSIERYSHVMHIVSTVTGRVTEDRTAFDVLTACFPAGTLSGAPKPRAMQIIEELEPSRRGLYGGCVGYLDFAGDSDTAIAIRTALLRDGTAYVQAGAGVVADSDPVAEDNECRNKAAAVLRAVHTANRLHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN28</accession>
    <name>A0A7K2ZN28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferric iron reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001460">
        <property type="protein sequence ID" value="MYW33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF_C" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="234" mass="24993" checksum="3ADDAEBA2BC2A083" modified="2021-04-07" version="1">MDLERTASVGGFFALRTAPVPGGSHRPLAELYAGGTAPLTARVDKVAARLVAPERRVAASIAHLGLAARLWSIALGPAALYGRIPALVPDTLHWDPQRTSPEDLWLADPEELPGTADRIREQVQYGHLVPLAEAVRRDGNISPQLLRGNAGSALAGAVRELVIWARGQDRPDVAQRARALAAELFDHPDLRSTGSPHGPAFRRRTCCLYWRCPGGGLCGDCVFDRAPGPSGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN39</accession>
    <name>A0A7K2ZN39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001444">
        <property type="protein sequence ID" value="MYW33708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="57"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="34314" checksum="A43AD10B4D1F4BB4" modified="2021-04-07" version="1">MSSTELPGTRAIAAAVAPTVSAVRVAEGERLRSVALPGLTLTVRSRPADRTGLPPALFVHGLGGSSQNWSALMPLLTDVVDPDAVDLPGFGDSPPPDDGNYSITGHARAVIRLLDASGRGPVHLFGNSLGGAVATRVAAVRPDLVRTLTLISPALPEWRVQRPAVPTGLLAVPGVAPLFARLTKGWTAEQRTRGVMALCYGDPARISDEAFRHAVAEMERRLELPYFWDAMTRSARGIVDAYTLGGQHGLWRQAERVLAPTQLVYGGRDQLVSYRMARRASAAFRDARLLTLPDAGHVAMMEYPEAVAQTFRELLDDGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNG6</accession>
    <name>A0A7K2ZNG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gndA</name>
        <name evidence="10" type="ORF">GT040_32675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="WWKE01001492">
        <property type="protein sequence ID" value="MYW33896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="181"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW33896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="480" mass="51529" checksum="CC5CC76DB7A6F430" modified="2021-04-07" version="1">MSGTAQIGVTGLAVMGRNLARNFARNGFTVAVHNRTGSRTDALVKEFGHEGTFVAAHTPEEFVAALERPRRLVIMVKAGDPTDAVIQEFAPLLEDGDVIIDGGNAHFEDTRRREKELRERGIHFVGAGVSGGEEGALHGPSIMPGGSAESYASLGPMLEKIAAKAEDGTPCTAHIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRRIAGYSPAQIADTFRSWNTGRLDSYLIEITAEVLAHTDAATGKPFVDVVQDRAEQKGTGRWTVQIALDLGVPVSGIAEAVFARSLSGHADLREASRELPGPVAKPLEGADASAFADRVEQALYASKVVSYTQGFHQIRAGSEAYDWDIDLGSVAAIWRAGCIIRAAFLDRIRAAYDSRPDLVSLLSDEEFGREIGAAQDDWRAVVAEAAHQGVPTPGFAAALSYYDGLRADRLPAALTQGQRDFFGAHTYRRTDREGSFHTLWGGDRSEAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNU1</accession>
    <name>A0A7K2ZNU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001532">
        <property type="protein sequence ID" value="MYW34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="10313" checksum="E5654AD2EBAAFFD3" modified="2021-04-07" version="1" fragment="single">ALLASEVPLAPGTTGRGAEALLEPAERAEQRLIGAVAALPPDASAEPYNEAQDAPWHQTRLLLRLHRYAHEVVLGAADPVLTGAGHALDLHRDAAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP81</accession>
    <name>A0A7K2ZP81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="476"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="561" mass="59692" checksum="F01679DABA21A2E6" modified="2021-04-07" version="1">MTDTGSAPSHYAAKPWLALLSDAQRAEVHPAETVLHAFRDTVARAPEDHPALAYFDGRLTYRETDTLSDSVAGHLAARGLRHGDRVAIMLQNSPHFVLALLGAWKAGATVVPLNPMYKSGEVGHVLKDAGVTALICSDRAWAAYLRETAEAAPGLTIALTACELDLQSVDDPRVLGFERLPAPGPDDLADDLLTVARAGHTPPDGRELTAADVALISYTSGTSGTPKGATNSHANIMVNAERQRTGHPVAEGSAYFALAPLFHITGMVCQLAACIANAGTLVLAYRFEAGVVLDAFAAHRPAYTVGPSTAFMALAAHPDVTPDHFASFQVISSGGAPLPPALVEKFRAGFGPYIRNGYGLTECTAPCASVPPEREAPVDPVSGTLSVGVPGPDTVVRILDESGQEVPFGEQGEIAVRGPQVVSGYWNLPEATEAAFPDGELRTGDIGFMDAAGWLYVVDRKKDMINASGFKVWPREVEDVLYTHPAVREAAVVGVPDAYRGETVRAYVSLRPGTSVEPGELGTYCEERLAAYKYPREVEILAELPKTASGKILRRELRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPB1</accession>
    <name>A0A7K2ZPB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001559">
        <property type="protein sequence ID" value="MYW34201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="39" mass="4040" checksum="580F80D1E806A689" modified="2021-04-07" version="1">PRFSATPVSVRSGPARPGADTDAVAADWDVPGLRPTPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPB6</accession>
    <name>A0A7K2ZPB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001544">
        <property type="protein sequence ID" value="MYW34109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="564" mass="62933" checksum="C559651B5C57C4D8" modified="2021-04-07" version="1">MTSTVPNAVQHTDAAAPPITMFGPDFPYAYDDFLAHPAGLGQIPATEHGQEVAVIGGGLSGLIAAYELMKMGLKPVVYEADRIGGRLRTVGFDGCDPSLTAEMGAMRFPPSSTALQHYIDLVGLETRAFPNPLSPATPSTVVDLKGESHYAETIDDLPQVYRDVANAWNACLEEGADFSDMNRALRERDVPRIREIWSQLVERLDNQTFYGFLCESEAFRSFRHREIFGQVGFGTGGWDTDFPNSILEILRVVYTEADDHHRGIVGGSQQLPLRLWDREPQKIVHWPLGTSLASLHGGEPRGAVTRLTRTAGNRITVTDATGDIRTFRAAVFTGQSWLLLSKIDCDDALFPIDHWTAMERTHYMESSKLFVPVDRPFWLDKDETTGRDTMSMTLTDRMTRGTYLLDDGPDRPAVICLSYTWCDDSLKWLPLSPQERMEVMLKSLGEIYPNVDIRSHIIGNPVTVSWENEPYFMGAFKANLPGHYRYQRRLFTHFMQDRLPEDKRGIFLAGDDISWTAGWAEGAVQTALNAVWGVMHQFGGATDPTNPGPGDVFDEIAPVELPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPC3</accession>
    <name>A0A7K2ZPC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001557">
        <property type="protein sequence ID" value="MYW34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="27700" checksum="C122F6EEBA8DDB61" modified="2021-04-07" version="1">MTVDPSHGCRISSLRIGSTELLRQGERYGCFPMVPWCGRTGYGQFRNGDVAHQLPLNSPPHAIHGTGRDTAWRTAHVDKAQAAFYYDLAEPWPYEGRVTQTFELTGDGLTLGLAVETYGTSFPAQAGWHPWFHRNLGGRDAQLSFDAAWQEERGEDHLPTGRRIDPVPGPWDDCFGMPDGVDVKLTWPEQLELTVKSRSEWVVVYDEQAEAVCVEPQSGPPNGLNTAPRLVTPIDPLEITTTWSWTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPT4</accession>
    <name>A0A7K2ZPT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001599">
        <property type="protein sequence ID" value="MYW34353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="532"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="919" mass="101453" checksum="8703551284A984AA" modified="2021-04-07" version="1" fragment="single">GRRRPDAAPHYPPAVPGGARQEAVNILHLAGPEFGRGREPEELLRDVQSGLIELRDGGAPSPDLVLVSGDVTASGSPRNCAQALDFLTGLRAQLRLAPHRVLVVPGNQDVSDAACQAYFHSCEADEIRPQPPYWQKWRHFSRLFEGLYQGLDTVFGSDQPWTLFPVPELRTVVAGFNSSIARTHRLEDRYGLVGRAQAAWFAETLRQYEEEGWLRVGLIRHPLLPHARGGGGSGTGSGTGEAPGPLRDTDVFQRLLAPRLHLLLHGPGGDGRDPDATPTHAELASATGALPLLGAAGPGRFSLLRVDAQGVKRWTPHEEGSSAEPVVHPVDWHSAPRFPDDTGDEEIPAHGPAHSDNRTVNDPGAQLAERVKDVLRARRPDVRLRDVRPLAPEDLTQIVAAWDEDDVVRLLRLAVQPGTPTDDDLDRLLALVHADDSGTDAELVYAGERPEPGLRERAARRGVRVRSFLELQGLIDLRGYVATQTAELSADGPYAPELYLPQRYRDEVHPGDGEGDDLVDEMLRLLETDQGRVLLLLGSFGHGKTFALRELARRIPERLPHLAPLLIPLRSLDRSHSLEGLVAAHLANRGVDVIDLRALRYMLRQGRVVLLFDGFDELVNRVSYERAAEHLHTLLKAAVDHAKIVVSGRTQHFRSDEQVLTPLGEQVGLLPQRRLLSVEGFAPHQIRRYLINYYGDEEAATRRYELLFGIRQLLDLCSNPRLLSFVAALDEQQIRAVARSGGTLSAARLYEDVFSTWLRFEERRGQGGPGAVPGLELDQLWRSVTVLALRLWESGRGSLPLAELTQIVAETFGQRDDRALFTHEAQAVGAGTLLVRVDDGVFRFIHESVLEWLVAREAARRLGRGDDTLLTKRELSPLAVEFFCDLADSQQITEWVRQTLESPGQDPDERAGGTTGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPU0</accession>
    <name>A0A7K2ZPU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001587">
        <property type="protein sequence ID" value="MYW34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="27926" checksum="B0FE155DDEF170C5" modified="2021-04-07" version="1">MTVHGMETEEADGRPLHERIAADLRDDIMSGELAPGDSLPSTAQLKERFGAANATVQKALQLLKAEHLVVGRAGASVTVREHRQRTIRPAAYMAPSSSGEPYRWLTEAANSGTSARSTLLDVTVAEPPADVADALALPAGGSAILRYQLLSIDDEPAELVASYYPLDIAEGTAISEPRRIPGGTPTLLASLGYPPRLSVDRVSARVATQEQYRLLRLSGGLPVLRTLRVVFSDDDRPIEATVMVKAGHLYEVQYEFTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ12</accession>
    <name>A0A7K2ZQ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_35455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001623">
        <property type="protein sequence ID" value="MYW34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512094.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001623.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="309" mass="32417" checksum="51815B7552F1C43D" modified="2021-04-07" version="1">MNELPQQLVNGLLLGSMYGLVAIGYTMVYGIVQLINFAHGEIFMTGGFGALTVWLILPSGTSVLLALPLMLIGAILVATLIAVGAERFAYRPLRGGPRLAPLITAIGLSLALQQAVWAWYPGAKSARTFPEIPGGPFELGPVTIQTGDVFLLIAAPISMAVLGYFVIKTRTGRGMQATAQDPDTAKLMGINTDRIIVVAFALGATFAAIGAVAYGLKYGEVQFRMGFLLGLKAFTAAVLGGIGNIYGAMIGGLTLGVAETMAAAYIAEVPGLEQLGGQSWANAWAFVLLILVLLFRPQGIMGERVADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQD9</accession>
    <name>A0A7K2ZQD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_36010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001636">
        <property type="protein sequence ID" value="MYW34537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="305" mass="32794" checksum="CAFFA50BA5778127" modified="2021-04-07" version="1">MAIIEVNGVRKTYAGRHVVDGVSFSVEEGEIFGILGPNGAGKTTTVECVEGLRIPDAGTIKVAGLDPVADHDRVTHLLGAQLQESELQAKLTVREALELYASFYPAPADWRPLVERLSLTDRLATRFAKLSGGQKQRLFIALALIGDPKVVVLDELTTGLDPRARRDTWKLIEEIRDGGVTVLLVTHFMEEAQRLCDRIAVIDRGKVVALDTPAGLIRQATGSTVISFVASRALTGPDLTRLTALPGVASVTPPDREGTLTVHGTDETVTPFVALLAELGVTARQLRITETSLDEAFLDLTGQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQE7</accession>
    <name>A0A7K2ZQE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001632">
        <property type="protein sequence ID" value="MYW34518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="91"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="20939" checksum="026FE5F15A55D1AD" modified="2021-04-07" version="1" fragment="single">MSIRHGLLALLERGPRYGSQLRTEFESRTGSTWPLNVGQVYTTLSRLERDGMVVQEGADEAGHDLYAITGDGRAELRSWFETPVDRTSPPRDELAIKLAMAVGAPGVDIRDVIQSQRHHTLKAMQDYTRLKAQALADVPANRDEVAWLLVVEQLIFQAEAEARWLDHCESRLVRLAGAAATDPSPEPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQS5</accession>
    <name>A0A7K2ZQS5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">GT040_36955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511069.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001681.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="28469" checksum="90D30DE3B4FAF9E3" modified="2021-04-07" version="1">MADAPYKLILLRHGESEWNAKNLFTGWVDVNLTEKGEKEAVRGGELLKDAGLLPDVLHTSLQRRAIRTAQLALESADRLWIPVRRSWRLNERHYGALQGKDKAQTLAEFGEEQFMLWRRSYDTPPPPLARDDEYSQFDDPRYADLPPELRPDTECLKDVVVRMLPYWFDSIVPDLLTGRTVLVAAHGNSLRGLVKHLDGISDEDISGLNIPTGIPLSYELDADFKPLKPGGTYLDPDAAKAAIEAVKNQGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQX6</accession>
    <name>A0A7K2ZQX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001687">
        <property type="protein sequence ID" value="MYW34781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="65"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="492" mass="52747" checksum="38E64B037C6C9414" modified="2021-04-07" version="1">AALLVPALSACGSDASSTTGNTTLKWASSYFPAHWDPVVSGSGAQFRQLALVYASLTRTDEQGKAVPDLAESWEYNDRGDRITFKLRPGQKFSDGEPIDATAVKAAIERAQKQKNSALFGDLTSIGKVEADGLEATLNLTQVDYQIPQLLGQRVLQIASPKAAEDPEKLDQNPVGAGPFVVQQLIPGTKAVLKKNPDYWDAENIHIDNVELVSAPDTSTVVSGLRTGVYNFADIDPSQADAAKKAGLDVFVQPGFNAANLSLNINKAPFDDDKVVDAVRHAVNREEFVQKLTFGYGEATDQPFPKGYVAYDPKSEDVYPYDPAKAKKLLAEAGHQPGDLKIDLVIPSEDPQAEIVQSQLAAVGIKVTIKIDKNWSTPFFAKDLTFSLYGTTGRDSAAQTLTAHFGPNGPLNLSTPYEPAGFEEAVAKVRQTPLDSPDYAATLQAATRAGLESKALVFTYASPNLFAKTKALSALPKNPGHIDWTGVKLSGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR82</accession>
    <name>A0A7K2ZR82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001693">
        <property type="protein sequence ID" value="MYW34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="244"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="421" mass="45723" checksum="CBC4BE5B9BD54BB1" modified="2021-04-07" version="1">MTRHGPLDEFCWMDLKTHDPSGTAAFFSSVLGWDFAVDEQDWRKAVTISAGDHRIGGLSDLARPAYPPGSPAHTAYYLAVDDVDRRTAVAAENGAQILVPPFDAGGQGRIATLIDPVGAVVSLWRPQGFAGWPVSPPDGAVAVPRSMVLACEDPERARHFYTGMTTGAPPARAAFAEAATITAPQWELALAVADLDGVAARARALGGELVTVAEGLARLSSPEGLTFRLQVPETSPAFLETDRLALRPFTDADAPALLALDNDPEVMQYINGGRPTTARSIRERTLPRLLHDHPCTGTRGFWAAEERATGTFLGWFELRPVDDQDRTVVELGYRLNRAAWGRGYATEGARALVRKGFTDLGAERVTANTMAVNAGSRRVMEKAGLTFLRAYTEDWPDTIEGSEHGEVEYVLTRAEWEKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRK6</accession>
    <name>A0A7K2ZRK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001735">
        <property type="protein sequence ID" value="MYW34985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16649" checksum="9ED28E487EEFC305" modified="2021-04-07" version="1">MSAPRPDVPALPVTFRPTLTRVVLLSVGLAMFLVITVIALMLERLNPGERITFIFVAALFLGVLALLSRPRVTADDTGVTVVNITRTRRLAWEEILRVNLRSGDPWVFLDLSDGTSMPALGIQPGMAKEQAIRDARALRALAESRSTAGDDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRM4</accession>
    <name>A0A7K2ZRM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001742">
        <property type="protein sequence ID" value="MYW35005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="19605" checksum="7209028113526AF3" modified="2021-04-07" version="1">LMRLRDVLSRADRTLTEARAARGEVLAKIAASEVPAVSGPATALQERLEIAAEYRRRAQWNRLSPLLESLEQEAEEELLRARESLTSVTAPLAVRAELRGRLDAYKAKVARHGLAEDPLLIERYDAARRMLWSAPCDLRVAEQNVLRYQQAAAELLTPRPADGPEDRRGDQGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRQ6</accession>
    <name>A0A7K2ZRQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_37995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001725">
        <property type="protein sequence ID" value="MYW34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="PTHR10909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="147"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="289"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ACOX" evidence="7">
        <location>
            <begin position="510"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="653" mass="71107" checksum="CC6433E72652CED9" modified="2021-04-07" version="1">MSTDRTPTAPAGYVQPELDVRALTEVLDGEYAEIRDLVRTNLVTYASVLEDAEELSIDAYRERVRDIVVEMAATGQTGMGFPKRYGGGGDVGASIAAFETAAFGDLSVLVKTGVQFGLFGGAILHLGTERHHDVYLPDLITGKLMGCFAMTETGHGSNVQALGTVARYDAAAQEFVITTEGEQARKDYIGNAARHGELAVVFAQLEVGGESEGVHAFVVPIRSGGEAVPGVDIEDDGRKMGLNGVDNGRIRFDGVRVPREALLNRFADVTPEGVYKSTIDNPDRRFFTMLGTLVQGRVSVGGAGVNAAKVALTVATKYALRRRQFAAGSQEEEQLLLDYGLHQRRLLPLIAQTYALHFAQDVLRAQLHNVFSGLEDDPQARRRLEARAAGTKALGTWHATRVIQECREACGGAGYLAVNRFAALKADSDIFTTFEGDNHVLLQLVAKGLLTDYASEFEDLDQLGMVRYVTGLAVETVIEKTSAHKLLERVRDLLPGGDEWDQEAGLLDSEYQLAMFRYREEHMLAGVARRLKAGVDRKGDPGAVFSEVQDHVIAVAHAHVERLVLEAFVEKMRTLPEGGDKVALGLLCDLYALSTIEADRAWFMEHGRLTVQRSKAITREVTDLCRKVRPLAGDLVDAWGVPSAMLRAPDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRW4</accession>
    <name>A0A7K2ZRW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001751">
        <property type="protein sequence ID" value="MYW35028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="8786" checksum="57695E9BE6890A46" modified="2021-04-07" version="1" fragment="single">MGIESDQLVYDYLSRVGDLAQQQQLSSGARMRLVSTLRGEIDRRRASEGADSPAAVRRIIGRLGSPAELVSAAAESGDGSVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS94</accession>
    <name>A0A7K2ZS94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_39500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001790">
        <property type="protein sequence ID" value="MYW35202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="327" mass="34862" checksum="08995C7605AF6EF4" modified="2021-04-07" version="1">MCAVRDLVKTYPAVRGRRGAPATPEVRATDGISLDVERGEIFGLLGPNGAGKSTLVRQLTGLMRPDSGSVEVLGHDLVRHPERASRLIGYLGQESTALDELTVSLAAETTGRLRGLHLREARAERDAVLEELGLTELAGRPLKKLSGGQRRLACFAATLVGDRPVLVLDEPTTGMDPVARRAVWAAVDRRRAERGATVLLVTHNVIEAETVLDRVAVLERGRVIACDTPSGLKEKVAGEVRVELMWRERAPLDVPEVAALRLSAQESGRRWVLRLGPDEARAAVAAVTGGAAFAALDDFTLATPSLEDVYLALGGDAANASKGLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSY3</accession>
    <name>A0A7K2ZSY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001852">
        <property type="protein sequence ID" value="MYW35442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6167" checksum="789221F22A174DBE" modified="2021-04-07" version="1" fragment="single">MPPAFRLVARPLPLWLGHVLRTQRGPVHGGAVVRGALAMLPLLLAAVADRPTAGVPAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Z3</accession>
    <name>A0A7K2Z5Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000008">
        <property type="protein sequence ID" value="MYW27758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="334" mass="37606" checksum="8E112E7F961C59DA" modified="2021-04-07" version="1">MPRPFTLFTGQWADLPLEEVCKHARDFGYDGLELACWGDHFEVDKALADPGYLDSRHQLLDRYGLKCFAISNHLVGQAVCDNPIDERHQGILPARIWGDGEPEGVRQRAAAEIADTARAAAAFGVDTVIGFTGSSIWHLVAMFPPVPPHMIERGYEDFAERWNPILDVFDAEGVRFAHEVHPSEIAYDYWTTKRALEAVGHRPAFGLNFDPSHFVWQDLDPVGFLYDFRDRIYHVDCKEARKRLDGRNGRLGSHLPWGDPRRGWDFVSAGHGDVPWEDVFRMLRSIGYEGPVSVEWEDAGMDRLHGAPEALANLKRFDFDPPSASFDAAFGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z655</accession>
    <name>A0A7K2Z655_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_00730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000022">
        <property type="protein sequence ID" value="MYW27830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW27830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="523" mass="56204" checksum="6C992B43B28FBC56" modified="2021-04-07" version="1">MTGTGPGPGNGERTQTQHDDDALGELGYRPELKRTLGNFHTFAAGISYISILTGTFQLFYFGVSFGGPAYWWSWPMVFCGQLMVALCFCELAARYPVAGSVYNWAKKMGGPHVGWLGGWMMMTATMVTLSAVALAYQITLPQIDGWFQFVGDGSGKNDQAANAVLLGSVLILFSTLVNAFGVKLMARINSAGVFIELVAAVALIIFLGAHITRGPSTALTETYGLGSGQSLGYFGAFLTASLASAYVMYGFDTASSLGEESHNPGRNAPRAILRALIASFLIGAFILLFALLSVPDLKAEELSTGGLQYVVLATLGDTIGEIFLWAVVVAITVCVLAVQAAGIRLMFAMARDNNLPAGSVLARVSPRFKTPVVPAVLIGVVGVVILVVNINQPQIFSVITSIAIIMIYVAYLLVTVPMLLRRLRGTWEPREGAFSLGRWGLPVNVLAVLWGTAMSLNLAWPRAEVYNATGPQHWYLRWGAFLFIGVVALGGFAYYWFVQRHRTGVLAGHRFEAEAPTAPPPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6A3</accession>
    <name>A0A7K2Z6A3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000036">
        <property type="protein sequence ID" value="MYW27864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="13206" checksum="08500006FA547500" modified="2021-04-07" version="1">MSEIAANTVHEAYAFACMRCGFGWEQSYEIEHHVDIHGHEFVVYTAGGERVPSPLSTPTCTNCGGHVVRIMRAGRVAGAQQFLHASKSAKRDPEKVPAARSADRHWRLSDLLHPFHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6A9</accession>
    <name>A0A7K2Z6A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prepilin peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000027">
        <property type="protein sequence ID" value="MYW27843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7137" checksum="FF5BBF1C939DF3D0" modified="2021-04-07" version="1" fragment="single">MDLVLLAVAAVWGGATGLLIPRAAYRFAVQPEEPWRTACPAGHAFTGPLGGWWGPARCTPCASRAQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6K8</accession>
    <name>A0A7K2Z6K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000062">
        <property type="protein sequence ID" value="MYW27970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511737.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000062.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="416" mass="46270" checksum="7B60EA9402B8E5F8" modified="2021-04-07" version="1">MRCPHLPDGFDFTDPDLLQARVPHPEFALMRQTAPVWWCTQPANISGFGDEGYWVVTRHADVKYVSTHPELFSSNTNTAVIRFNETISRDQIEVQKLIMLNMDPPEHTRVRQIVQRGFTPRAVRSLEQALRARARSIVETAHASAGADGSFDFVTNIAVELPLQAIAELIGVPQEDRSKIFDWSNKMAAYDDPEYAITEEVGAEAAMEIVAYSMNLAAARKECPAQDIVSQLVAAEGEGNLSSDEFGFFVILLAVAGNETTRNAISHGMHAFLTHPEQWELYKRERPKTTAEEIVRWATPVVSFQRTATQDVELGGQRIRKGERVGLFYSSANNDPEVFDAPEAFDITRDPNPHLGFGGGGPHFCLGKSLAVMEIDLIFNAIADVLPDLRLLEDPRRLRSAWLNGIKQLQVSASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Z7</accession>
    <name>A0A7K2Z6Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000099">
        <property type="protein sequence ID" value="MYW28092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="48"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16534" checksum="46A3553587221464" modified="2021-04-07" version="1">MVSHAQWKLARDRKVAESISEGEDSAESAERVRRRLELDLAWDLGQAVYDRRTALGLAQTELARRARMSQPQVSKLELGGSMPTVPLLARLARALDADFSLTPLGEGVRVSFIPHDPARTEAGTEPPSSEHASTSASTPDAEADASAERTAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Z9</accession>
    <name>A0A7K2Z6Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000102">
        <property type="protein sequence ID" value="MYW28121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241379.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000102.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6743" checksum="856B4432428B7A73" modified="2021-04-07" version="1">MAISLSMVLLFAVILVVLIRGGSIKPGPALVAVLFGFFLASTGMAPSINRFMNSIADTINQISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z711</accession>
    <name>A0A7K2Z711_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IucA/IucC family siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_02155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000100">
        <property type="protein sequence ID" value="MYW28105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="174"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="445"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="633" mass="70382" checksum="74C91679E81A8AE3" modified="2021-04-07" version="1">MPTYPASPDSVEPHPLLSPPELNRQVWDRAAARLLAKMLGEFAYEEIIEPERRPGDSHLHSLSLDDGTELRFSARRGVYGSWRVDPDSIETAHPPASPLSNGASSSHAAVNGTSDGTARPFRDPLRFLVRARGLLGLDGATLGHLIRELTLTLSADARLDHTALTARELADIGYAELEGHQTGHPWLVASKGRLGFSAADAARFTPETRSPLQLPWIAVSTRIAQYRGVGRLTTPEHLYAQELDPSVRASFTAELHARGLDPASYLFLPVHPWQWDEWIVPLFAPAIADGDIVALHTDGDARLAQQSVRTFANVSRPDRHTVKLPLSILNTLVWRGLPTERTLAAPAVTAWVQGLCEADPFLRDTCRVILLGEVASVAVEHPLYDHLPEAPYQFKEILGAIWREPLPPRLAPGERARTLASLLHTDPAGRAFTAELVERSGLAPEAWLTRLFAALLPPLLHFLYRYGTVFSPHGENAIVVFDENDVPVRLAIKDFVDDVNVSAHPLPEHDTMPEEVRTVLLTEAPSFLTQFIHSGLFVGVFRYLSPLCEEQLGVSEDAFWSLVRAEIVRHHARFPELKERFELFDMLTPEIERLCLNRNRLHVDGYRDRSSRPHAAIHGTVANPLHPSARIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7M6</accession>
    <name>A0A7K2Z7M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000147">
        <property type="protein sequence ID" value="MYW28360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="48" mass="4854" checksum="E5D354137157DA0E" modified="2021-04-07" version="1" fragment="single">MRDPAEGPESGPAATPARPGALGLFSGLRPVTLGVWVLAQALAIAWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7T6</accession>
    <name>A0A7K2Z7T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_03810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000159">
        <property type="protein sequence ID" value="MYW28420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="186" mass="19860" checksum="D1E9F6DCE8E6D67E" modified="2021-04-07" version="1">MQNRTPRIPEQPTPNPVDADAGLTVELASVVTGARRRALRDGDRQIDTAHLLHSLIESDPEVREAFDGGPQLAKVLGYLVQRSIGYGLRWQGSVEDSGAVPVVRDPAADVVREPAAEGWSPSAVTAMEDALHRAGLRGESRARGLDLLAALAADGECRAVEVLGRAGVDARWLSGRAVERTAEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7U6</accession>
    <name>A0A7K2Z7U6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_03635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000150">
        <property type="protein sequence ID" value="MYW28385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007452441.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000150.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="20713" checksum="E41327CA1FD0BC19" modified="2021-04-07" version="1">MLTVGDKFPEFDLTACVSLESGKEFEQINHKTYEGKWKIVFAWPKDFTFVCPTEIAAFGKLNEEFADRDAQVLGFSGDSEFVHHAWRKDHPDLTDLPFPMLADSKHELMRDLGIEGEDGFAQRAVFIVDQNNEIQFTMVTAGSVGRNPKEVLRVLDALQTDELCPCNWTKGENTLDPVALLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7V2</accession>
    <name>A0A7K2Z7V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000165">
        <property type="protein sequence ID" value="MYW28439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="183" mass="19684" checksum="959C58806322032C" modified="2021-04-07" version="1" fragment="single">MRAVRRPFRPARALTPTARVRRLRRRITVLFALTSAAGLVAMAVLAVRSDGVRWREQLDQGMSADTNWALGLLETDEDGRLDTEVLLDNAGTACPPLFLLSVPAVPGEPSVTPAPGELVVEHAPRRPCLTMPAGAVRQAAATAVRADEPRSRDARTADGEPVRMFALPFYPPNAEEDAAPQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8M3</accession>
    <name>A0A7K2Z8M3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">pdxS</name>
        <name evidence="6" type="ORF">GT040_05290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000246">
        <property type="protein sequence ID" value="MYW28696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030574184.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000246.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="306" mass="32381" checksum="B75783A406AEEDE1" modified="2021-04-07" version="1">MSTLPSTPQSAESPAIGTARVKRGMAEQLKGGVIMDVVDAEQAKIAEDAGAVAVMALERVPADIRKDGGVARMSDPNMIEEIIGAVSIPVMAKSRIGHFVEAQVLQSLGVDYIDESEVLTPADEVNHSDKFAFTTPFVCGATNLGEALRRIAEGAAMIRSKGEAGTGNVVEAVRHLRQIKNEIARLRGFDNNELYAAAKDLRAPYELVKEVAELGKLPVVLFSAGGVATPADAALMRQLGAEGVFVGSGIFKSGDPAKRAAAIVKATTFYDDPKVIADASRNLGEAMVGINCDTLPESERYANRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8P7</accession>
    <name>A0A7K2Z8P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_05325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000246">
        <property type="protein sequence ID" value="MYW28703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="49"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="143"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="186" mass="19898" checksum="396499A756BB7325" modified="2021-04-07" version="1">MLIGMTSEPEQQIGVGTPDAFQRLWTPHRMAYIQGQDKPNGPGAEDGCPFCSIPAKSDEDGLVVARGEHVYAVLNLYPYNGGHLMVVPYRHVADYTELDGPETAELADFTKRAMAALRAASGAHGFNIGMNQGSVAGAGIAAHLHQHLVPRWGGDTNFMPVIGHTKVLPQLLGDTRAMLAGAWPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8S2</accession>
    <name>A0A7K2Z8S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4245 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000249">
        <property type="protein sequence ID" value="MYW28736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025339">
        <property type="entry name" value="DUF4245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14030">
        <property type="entry name" value="DUF4245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="190" mass="20283" checksum="3FB49B2760877377" modified="2021-04-07" version="1">MDAVAESKRGKQTARNMFLSTMVTAACAGVIYIFVPHDENLDPVKAVDFTVELATVRTTAPYPVAAPEGLPEKWKPTSVSYDATAGKAWHIGFLDPDGKYVAVEQSTAAARTYVAQVSQKAKDTGTTAKVAGREWQVWEGEKYDALVLPEKGHTTVVTGSAPRERLVEMAEALKTQPVGGMVPSASPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8X4</accession>
    <name>A0A7K2Z8X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000250">
        <property type="protein sequence ID" value="MYW28745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515422.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000250.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="209" mass="22884" checksum="77509A299710D946" modified="2021-04-07" version="1">MSTAEETSGDDAPWGEVTPEAARRLLVAAVDAFAERGYHATTTRDIAGRAGMSPAALYIHYKTKEELLHRISKIGHDRALYVLQAEADRDGTAADRLAGAVRSFVRWHAERHTTARVVQYELDALGPEHRTEIVELRRRSDAVVRRIISEGVAAGEFDVPDIPGTTLAVLSLCIDVARWFNAQGSRTPDEVGALYADLVLRMVGAPPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z925</accession>
    <name>A0A7K2Z925_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000258">
        <property type="protein sequence ID" value="MYW28822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="21985" checksum="BDDDA0F0EDD70442" modified="2021-04-07" version="1">MRSSGDGTAAGGPYPQHGSGADHAIRQPVQPAAMAAGGVAAASDAGDIGYRGPTACAAAGITYRQLDYWARTGLVEPSVRPAYGSGTQRLYSFRDVVLLKIVKRFLDTGVALQNIRTTVQHLRARGFQDLERMTLMSDGATVYECSSPDEVVSLLQGGQGVFGIAVGVVWRDVDAALSQLHGERVDTGETLIGNNPADELARRRNRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z933</accession>
    <name>A0A7K2Z933_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_06060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000263">
        <property type="protein sequence ID" value="MYW28846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="26970" checksum="7C4CC74BAD637ADB" modified="2021-04-07" version="1">MESPHGAAVGAEDFGLKGPRGWVFRHVGFSAPSGSLIAVEGPSGSGRTCLLLALTGRMRATEGSAETGGLELPRKAAAVRRIAALGPVPGVSELDPAFTVAEHLRERALLQGRYGASLRTLLRPRAERRATARARIDTALEAAGLDTATLPKAERTSVRDLERLEALRLSVALALIGTPRLLALDDADLKLSPAERADAWALLRSVADSGTTVLAVCSEAPEDVQVVRTAPATAEEAPTSPTTEEEETADAIAETGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9F6</accession>
    <name>A0A7K2Z9F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylyltransferase/sulfurtransferase MoeZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moeZ</name>
        <name evidence="5" type="ORF">GT040_06730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000303">
        <property type="protein sequence ID" value="MYW28976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561087.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000303.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="300"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="392" mass="42618" checksum="76033D2183F4F959" modified="2021-04-07" version="1">MSLPPLVEPAAELTVDEVRRYSRHLIIPDVGMDGQKRLKNAKVLCVGAGGLGSPALMYLAAAGVGTLGIVEFDEVDESNLQRQIIHSQADIGRSKAQSAKDSVLGINPYVNVVLHEERLEAENVKEIFAQYDLIVDGTDNFATRYLVNDAAVLLNKPYVWGSIYRFDGQASVFWSEHGPCYRCLYPEPPPPGMVPSCAEGGVLGVLCASVGSIQVTEAIKLLAGIGDPLVGRLMIYDALEMQYRQVKVRKDPDCAVCGENPTVTELIDYEAFCGVVSEEAQEAAAGSTITPKQLKEWIDGDEKIEIIDVREPNEYEIVSIPGAKLIPKNEFLMGNALQDLPQDRRIVLHCKTGVRSAEVLAVLKSAGFADSVHVGGGVIGWVNQIEPEKPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9K5</accession>
    <name>A0A7K2Z9K5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ORF">GT040_06620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="WWKE01000300">
        <property type="protein sequence ID" value="MYW28955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="290"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="462"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="609" mass="66095" checksum="F25DA70E872F0243" modified="2021-04-07" version="1">MCGIVGYIGKRDVAPLLLEGLQRLEYRGYDSAGIVITSKTAAGKPGTLKMVKAKGRVRELEAKVPKRFAGTAGIAHTRWATHGAPSDENAHPHLDADNKVAVVHNGIIDNASELRAKLTADGVVFLSETDTEVLVHLIARAQADTLEEKVREALRHVEGTYGIAVMHADFNDRIVVARNGSPVVLGIGEKEMFVASDVAALVAHTRQVVTLDDGEMATLKADDFRTYTTEGSTTTATPTTVEWEAESYDMGGHDTYMHKEISEQADAVDRVLRGRIDDRFSTVHLGGLNLDAREARGVRRIKILGCGTSYHAGQIGAQLIEELARIPADAEPASEFRYRNPVVDPDTLYVAVSQSGETYDVLAAVQELKRKGARVLGVVNVVGSAIAREADGGTYVHAGPEVCVVSTKCFTNTVVAFALLALHLGRIRDLSVADGKRIIDGLRRLPEQISEILAGEDEIKRLAAEYAEAKSMMFIGRVRGYPVAREASLKLKEVSYIHAEAYPASELKHGPLALIEPAMPTVAIVPDDDLLEKNRAAMEEIKARSGRILAVAHQVQEKADHTIVVPKNENELDPILMGIPLQLFAYHTALAMGRDIDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9P3</accession>
    <name>A0A7K2Z9P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000321">
        <property type="protein sequence ID" value="MYW29059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="209" mass="22373" checksum="F5A0B2906752FB3D" modified="2021-04-07" version="1">MPSPDSVPESALASRRSKITPERAQELYTAVLDLVRESGYESLTMEGVAARTRCGKSTLYRQWGSKPELVVAALHGTRRMRLPDIDTGTLAGDLLEAARAIGEASGRDTPLMHALSHAALQTPELLCALREALILPEIAAIDAMVRRAQARGEIAADLPGAEYVAAQLLGVMRARPLLEGRYADAAYLTRFVEKAILPGLGLTAGTPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9U7</accession>
    <name>A0A7K2Z9U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015610481.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000356.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13385" checksum="1DAE216A7133F120" modified="2021-04-07" version="1">MTTAPRPRPGRDDDPDRLYTLTGGRSRSDSAAFDLVTLVVAECDPAPGMQSEHVAILRMCQGPTAVVEISATLNLPVSIVRIMLCDLLDTGRISARHPRTSRVADRLPDPDILEQVLVGLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9W0</accession>
    <name>A0A7K2Z9W0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microbial collagenase</fullName>
            <ecNumber evidence="4">3.4.24.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GT040_07490</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'.</text>
            <dbReference type="EC" id="3.4.24.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.3" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000354">
        <property type="protein sequence ID" value="MYW29123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013661">
        <property type="entry name" value="Peptidase_M9_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002169">
        <property type="entry name" value="Peptidase_M9A/M9B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01752">
        <property type="entry name" value="Peptidase_M9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08453">
        <property type="entry name" value="Peptidase_M9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00931">
        <property type="entry name" value="MICOLLPTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029584852" description="Microbial collagenase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M9_N" evidence="15">
        <location>
            <begin position="103"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PPC" evidence="14">
        <location>
            <begin position="688"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW29123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="768" mass="82650" checksum="87DB12290656D5ED" modified="2021-04-07" version="1">MRRRAATLAALALCMCLGTASFAAPSFASAPRFQESQESSQSAQAPVAAMAPAAAADAPEPDHLRASALPVDERGPAPASDAARQQDYDEPAEGPGAAPAAACDPADFTSRTGSALVQQIKASDTACVNTLFGLTGENARLAFREAQMVTVASALRDASAAYPGNGSTSVPQLVLYLRAGYYVQWYNEPAVGPYGPALTTAIRSGLDAFFASPRSRDVTDANGEALSEAVILIDSSQENARYLPVVNRLLTGYDTSYNALWNMRAAVNNTFTVLFRGHQLPAFVAAVTADRSTADTVHSFAARNLALLGAEHAFLVTNAGRELARFLSYEALRAGVRPQVKGLLDRTSITGVTAPLWVGLAESANYYDTGNCAYFATCDLPARLDRAALPVRHDCSASLRIRAQEISAAQLASTCASLAGQDAFFHSIARDDGPVAGDLNTRLEVVVYNSSDDYGTYAGAMFGIDTNNGGMYLEGAPSAVGNQPRFIAYEAEWLRPDFQIWNLNHEYTHYLDGRFTMAGDFADGMTTPTVWWVEGFAEYVSYSYRRLTYDAAIAEAGKRTYPLSTLFDTTYDNGDSTRIYRWGYLAVRYMVQSHRADLDTVLRHYRAGNWNAARTHLKTTIGTRYDAGWNAWLTACAAGDCGEATNPPDPTDPTDPPDLPECTLPERTRLDRDCARSGISARAGDYAYLTLYVPAGTTKLRLSTHGGTGNADLYHRAGSWPSKTDFTHRSAKPGNAETVTVNNPTPGWNYVSIAAEQAVSGLVVSAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA56</accession>
    <name>A0A7K2ZA56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000375">
        <property type="protein sequence ID" value="MYW29261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029811865" evidence="2">
        <location>
            <begin position="28"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="435" mass="45683" checksum="742E7663AE8F6886" modified="2021-04-07" version="1">MSCTHRTTRLALVASAASLALLTTACGGGSGSDASGPGDGKPVTLTFWSATAGAKETAEAFNKTHSGITVKFSLVPAGPEGVTKLSNAVKGGNAPDIATMDYSALPEYASEGNLEDLTPSSGELVKKEFPEAVQSLVNLGGSTWAVPFDVTPIQLYYRKDLFKKYGVEVPRTWAEYRKAAEKIHQGDPDLTITNFGGGDPALLSGLAWQAGAQWYGTKDDAWKVNIDEPASQKVAAYWDGLLKDGLASKTPLWGEGETKERATGKVATIIGAAWSAGNFPVSYPDSKGKWGIAPLPTWDGTPSTGMYGGTSYIVPKGSKHTEAAAEFIKWVTTDPKAMTARLSSLKTPSSALPANESMRAAAAKEFDSSYFGDQDVYRLAGEAAGTIVPGWTWGPVQQQVTSAQMAAGGDHTKMLSAGQTKGESAVTDRGLKLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAS6</accession>
    <name>A0A7K2ZAS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000421">
        <property type="protein sequence ID" value="MYW29467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="29439" checksum="1D79F5A0AC174B2F" modified="2021-04-07" version="1">MKILISADMEGATGVTWPADVLPGTPQWERCRPMFTSDVNAAALGFYDGGADEVLINEAHWSMRNLLLEQLDDRVQMLTGRHKSLSMVEGIQHGDVDAVAFVGYHTGAGTEGVLAHTYLANSITGVWLNGARASEGLLNGQVAAEYGVPVVLVTGDDLTCVDAEGYAPEARKVAVKDYVSRYAAVCRTPARTAADIRTAAREATALAGRQAPVTRGTYTVELEFDAEHLAAAATVVPGVAPSGERRVAYTSATMYEGIRTFKAVTTIVSAAVEEQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAY7</accession>
    <name>A0A7K2ZAY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000424">
        <property type="protein sequence ID" value="MYW29488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="212" mass="23488" checksum="1BEB47A56F82BBC5" modified="2021-04-07" version="1">MSRPAGILRPYRPEDRDALFDICVRTGHEGGDSRHLYEDPDLLPNIFAAPYVVLEPELGFVVEDGGRAVGYILGTADTASFVARYRTEWLPGLADRYPAPVQPQSPSTPAEMMTGLMHDPERMVLPELDAYPAHLHIDLLPSHQRYGYGRRLMETFLDALHARGVPAVHLSMLTSNTPARAFYDRVGFHEIAVPDPGPVTYLGRSTAATPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB49</accession>
    <name>A0A7K2ZB49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000457">
        <property type="protein sequence ID" value="MYW29580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="136"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="212" mass="22405" checksum="7F1086A9522E220A" modified="2021-04-07" version="1">ALPAALSEGRAEPLARLIGALRSYHDAAVEPYWPHIRASIEADRAVRGRALLDGGADGLLAALPPMIRWRAPVLEADYPVDRDLYLDGRGLLLQPSFFCRGTPVVYRDPSLPPVLVYPVTHPGAPEFAEPGPWLGRLVGHTRSAVLQSIGNGCTTSELARRAGVSLASASQHASVLREAGLVLTLRHGSSVLHTLTPLGGSLLRGGAPLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB70</accession>
    <name>A0A7K2ZB70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000453">
        <property type="protein sequence ID" value="MYW29562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="398" mass="43459" checksum="CD1FE8508BBD43A6" modified="2021-04-07" version="1">MTEPPEDPAAPAAAEPRPPSGPAGALADGSGSGGEVLGGSGAATHGDFADASPAATGPRSVTTRATLAGVVVSALLIVAIVLGSRMLRNFDSALLPYAVATVFLAFGVAYRYTVWISAPGARRLFRQGWRSLFSYENFRQAPTALPKMIATYLGFQKFLGARSHARWAAHQLIFWGCILAALITFPLTWGWFTFTSGSGSGPGYEMRIWGVKILGFDSLSVFGWLMFHGLDIAAVLVIPGASYFLWRRMKDRGASTGQRFAYDLVPLIALIVISVTGLLLTFSSIFLHGGGYQFLAILHMVSVVFTLIYIPFGKFFHIVQRPAAVGMQLFKYTGRQDDQVFACRRCEEPIDTGPYVENLRGTMRDLRLDFDAWAEYCPRCKRVLRGSAYLSHVKKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBD5</accession>
    <name>A0A7K2ZBD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000455">
        <property type="protein sequence ID" value="MYW29575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="84" mass="8303" checksum="B74BCFDBB545FF29" modified="2021-04-07" version="1">RGRLAVTTPDAADAARILDGHGLTGLNVAGDRLTADAPPTTVDLADLNAALVGGGVRVRSFGIEGGSLEDAFVALTGEGFDVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBJ2</accession>
    <name>A0A7K2ZBJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_10675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000490">
        <property type="protein sequence ID" value="MYW29730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="12">
        <location>
            <begin position="26"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW29730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="212" mass="23299" checksum="A333E3A5C3A21F4E" modified="2021-04-07" version="1">MTTAAVDHHSPSDQDEDGGKPTFGAGRGLALLLVITGAAGLLASWVITIDKFKLLEDPSFTPGCSLNPVVACGNIMKSEQASAFGFPNPMLGLVTYGMVIAIGIGLLAGARYRSWFWLGLNAGTLFGVGFCTWLQYQSLYNINSLCLWCCLAWVATIIMFCYVTTHNVKHRILPAPAWLRSGLTEFHWVPPVLWIGIIGMLILTRWWDFWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBJ4</accession>
    <name>A0A7K2ZBJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein GT040_10535</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510616.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000489.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="18025" checksum="71B1FCA8034442A5" modified="2021-04-07" version="1">MADSSFDIVSKVERQEVDNALNQAAKEISQRYDFKGTGASISWSGEKILMEANGEERVKAILDIFQSKLVKRGISLKSLDAGEPQLSGKEYKIFATIEEGISQENAKKVAKIIRDEGPKGVKAQVQGDELRVSSKSRDDLQAVQALLKEKDLDFAIQYVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBL4</accession>
    <name>A0A7K2ZBL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF349 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000490">
        <property type="protein sequence ID" value="MYW29734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="409" mass="46037" checksum="42FBA83A8AF500C4" modified="2021-04-07" version="1">MSSDPWGRVDETGTVYVRTADGEQVVGSWQAGSPEEALAYFERKYDGIVVEIGLLERRVKTTDLSAKDATTAIDHLRRQVDEHHAVGDLDALRKRLDALVATVEARREERKVLKAKQTDEAKHAKEALVAEAEELAQSEQWRSAGERLRALVDTWKGLPRLDRKSDDELWHRFSHARSAFSKRRKAHFAALDAQREDARKAKEKLVTEAEALSGSTDWVTTAARYRDLMTEWKAAGRAQREAEDDLWNRFRGAQDVFFAARSEVFAERDAEQGENLKLKEELAAEAEKLVPVKDLKAARAAFRSINERWEAIGHVPRDARPKVEGRMQAVERALQESEESEWRRTNPEARARAAGLTGQLQAAVDKLRGQIDTARAQGNNARADKLAKELEGRQALLDQALKGLEEFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBX4</accession>
    <name>A0A7K2ZBX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000512">
        <property type="protein sequence ID" value="MYW29856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="209" mass="22828" checksum="9C5636D1CCCE98DB" modified="2021-04-07" version="1">MSVHLQTSLFDQGDEVAVRPLHGLRREHLGHGAWIDVLPQWLQGADALFETLAREVAWRAEERVMYERVVAVPRLLAFFGGGDPLPHPALDAARTALSAHYAAELGEPFTTAGLCYYRDGRDGVAWHGDTIGRGSTEDTMVAILSVGAPRHLALRPRRPGPVPVRRSLGHGDLIVMGGSCQRTWEHAIPKTARAAGPRISVQFRPAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC10</accession>
    <name>A0A7K2ZC10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000531">
        <property type="protein sequence ID" value="MYW29900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="19255" checksum="6132885F6E6D5DDC" modified="2021-04-07" version="1">KTEVASVVFCTLRFAPETAAWIAEQAAVDGWFTARAQWLGSLYAEGSASEYADSPWRREKGGLWDVGPHALSVLIPVLGEVEHLTAARGPADTTHLILRHTSGASSTVTLGLSAPPAAAGMDIELRGEHGTAAIPGWDGAEAAFRGAVDALAEAVRTGVPHACDARFGLRLTELLAEAETQAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCG1</accession>
    <name>A0A7K2ZCG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000547">
        <property type="protein sequence ID" value="MYW29955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="252" mass="27992" checksum="1F9F7603DA9280B0" modified="2021-04-07" version="1">MSFPPPGRHSGAAHHEYCNTGLCCRCQMRTWTTKAGNERLCGPCAACCQECGRAPAPHLDGLDGGLCAECRGLCERCHAPRRLDGSCACDRWRENAKSNPRGYVLQALPQQLLQALGGRVPSTVHDLIHDELGRNRSAGLLRERIERRWNLRWAHALNEKDEDGRRRWSAQDIAEQLLMPGSCSDPECEDGHLATTDAPCTRCRQPLHRFVTSVADHTATPEHAHAAAARIRRAMLENRSRKKLPPRGRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCN0</accession>
    <name>A0A7K2ZCN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="23579" checksum="B8BA2C3227427F54" modified="2021-04-07" version="1">MTVHEELAEGVWEDIQESPEAVAAMFRLRNRHIRGEMDEGGLYGTGYADALGSSARFPPKKWPLAQHAAFINIHAMIGAGDVTFTCISTGGTPGPDADRAGNAAKLAMTHERFKAELDMDQNGADADGMLSWQGPLVASRPTGDFFYPSSCRDVQQAPLTRLGEVPEGSAPLEVGDSWPSRTLMHLHQYGAVARWPYGSSLIWLFIRLKHQAITDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCX4</accession>
    <name>A0A7K2ZCX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000603">
        <property type="protein sequence ID" value="MYW30172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15481" checksum="AC78CF59F335B704" modified="2021-04-07" version="1">MLRNALSRLRGAPRPRTPEEPRGVRVRLSLPPSMSASLGCDAVGVPARHGFRLMSHLPRTGCVFADADRWWWIVPAGSDLDLDWPEQVMYARGADVPAVRPRLIHSPDSLTPYTPPIPLFLMVCQVAGVAPTWARSVVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCZ1</accession>
    <name>A0A7K2ZCZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000606">
        <property type="protein sequence ID" value="MYW30192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="18820" checksum="BC2364DBA0211EFE" modified="2021-04-07" version="1">LFGEGARGPELLLMERAGTLRSHPGQPSFPGGSLDPDDGDQATTGPLRAALREAEEETGLDPRGVQLFGVLPRLYIPVSSFVVTPVLGWWRAPSPVGVVDPAETARVFTVPVADLTDPANRATAVHPSGHSGPAFLVESALVWGFTAGVIDRIVHYAGWERPWDRARQVPLDWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD01</accession>
    <name>A0A7K2ZD01_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-oxogl_dehyd_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000608">
        <property type="protein sequence ID" value="MYW30202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-oxogl_dehyd_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="9678" checksum="D29CBF775B7C1FAF" modified="2021-04-07" version="1" fragment="single">MSSQSPSNSSISTDQASPGTNPAAAFGANEWLVDEIYQQYLQDPSSVDRAWWDFFADYKPGSSGTADKPVPGAAASGAAATETPAAAAPAQAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDH0</accession>
    <name>A0A7K2ZDH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS glucose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_13925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000657">
        <property type="protein sequence ID" value="MYW30358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512548.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000657.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="15302" checksum="E6A3ADBAD14A9F4C" modified="2021-04-07" version="1">MTNVTSPLAGRAIGLTAVPDPVFSGAMVGPGTAIDPVREPSEAVSPVDGIVVSLHPHAFVVVDADGHGVLTHLGIDTVQLNGEGFELLVNKGDTVTRGQSIVRWDPAGVEAAGKSPICPIVALEATAESLSDVREDGDVKVGDTLFGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDL0</accession>
    <name>A0A7K2ZDL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000670">
        <property type="protein sequence ID" value="MYW30443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="22890" checksum="02A2EB2B64423B79" modified="2021-04-07" version="1" fragment="single">MGTQQVSAPLRAPSSGVVHINIRLTDGYSIISNRLSQHRDLSLLAIGLGTHIQSLPAGKRIGIKVLAAIFPESEAAIAAGLRELEQHGFLRRTRERVRGGRVATRTESYNHPEAAARSAAPAPVREPEAEPVREPEAASVRQPEAEPVREPEAEPVREPEAEPVPESEAASVRESETEPVPEEPAPVPRLVPPRTAPKPPPPPLPGPCRPTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDY4</accession>
    <name>A0A7K2ZDY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000716">
        <property type="protein sequence ID" value="MYW30577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046081">
        <property type="entry name" value="DUF6099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19594">
        <property type="entry name" value="DUF6099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="166" mass="17304" checksum="F1F61A83EB60160F" modified="2021-04-07" version="1">MEAERLIEAGRRALAESRGALDVMAEAWQAQALARTVGSRLALFGPMELRGEARALGEIGGGCAAPDHPAVLSRGTRAAQLSQIADVRAALAGLALLLGEAGIALVSVACDTGEDGLYWQCIEAMDAADESLDRVQGLLRRLTERERERDGPYGGIRGPAPSAAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE75</accession>
    <name>A0A7K2ZE75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000729">
        <property type="protein sequence ID" value="MYW30667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="33" mass="3557" checksum="93A9DE97F42AE78F" modified="2021-04-07" version="1" fragment="single">MRDQDDGEQRDRVMRDDGTPDPAPDPDPASGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEA7</accession>
    <name>A0A7K2ZEA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_15515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000725">
        <property type="protein sequence ID" value="MYW30648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="383" mass="40179" checksum="7D0EF86FFD6F3502" modified="2021-04-07" version="1">MSASLSSQKTAAALRRSARVSLELLLVLLMAAVALWLLGRTWPVVWPLIVGLLLTTLTWPFARFLRRHGWRPAPAAALVTVLFLLVGTGIVALIAIPVASQSGQLADGVIEGIGRLREWAAGPPLNISDDQITGAFDAAVDRIENSAGSVVTTAVTGVSTVFSGLITAVLALFLMFFFLKDGPRFLPWLSRQLPGRLATDVPVVAERCWDTLGSFVRSQAFVGLLDAVFIGIGLWILGVPLVLPLAVLTFVSAFVPIVGAVFAGFVAVLIALVSNGLTDALIVLAIIIAVQQLEGNVFQPMIQSRGLGLHAAVVLLAVTLGGSLAGVVGSLLAVPVAALIAVIWNYLREQLSDPREGPEQGDREPEPEPAPDGGPDADAPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEG5</accession>
    <name>A0A7K2ZEG5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argR</name>
        <name evidence="13" type="ORF">GT040_16010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000756">
        <property type="protein sequence ID" value="MYW30741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515284.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000756.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="11">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="12">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW30741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="19017" checksum="6926662113EBE139" modified="2021-04-07" version="1">MTEAQETEHGGPSVPQTRTARHRRIVDILNRQPVRSQSQLAKLLADDGLSVTQATLSRDLDELGAVKIRNTGGELIYAVPSEGGFRTPQAPLGGSAKEERMRRLSAELLISAEASANLVVLRTPPGAAQFLASAIDQAELHDILGTIAGDDTLMLISRDPAGGQALADHLLRLAQNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEW2</accession>
    <name>A0A7K2ZEW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16816" checksum="C30B489151B9C56B" modified="2021-04-07" version="1">MEFVDTSILCNLLEVPGKCQDRKQVIDELKSKRERRGTDLLLPVTAIIETGNHIAQVSDGRARRSCAERLSGVLTTVIEGKAPWALNEVEWDAAHLQALVDGGNTGSSLIQHACNKLGCGDLNILIERDRYLARTSGVRATIWTLDELLSSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF21</accession>
    <name>A0A7K2ZF21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16735</name>
        <name evidence="3" type="ORF">GT040_38015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000773">
        <property type="protein sequence ID" value="MYW30875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001725">
        <property type="protein sequence ID" value="MYW34922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033595422" evidence="1">
        <location>
            <begin position="25"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="33" mass="2968" checksum="A0EC817B3E7FA0E4" modified="2021-04-07" version="1" fragment="single">MKNLKKAAAVTMIAGGLIAAGAGAASATGHSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF58</accession>
    <name>A0A7K2ZF58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_17280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000811">
        <property type="protein sequence ID" value="MYW30983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="10303" checksum="444D59371C1338C9" modified="2021-04-07" version="1">ARAIGAKRGQVVTSVVLPSALPEILVGVRLAFGIAYSSVVAAETVNGLPGIGGLIRDAQRYNQSDTVVLGLFAIGISGLLIDAGLRVLSDRLAPWRRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFC3</accession>
    <name>A0A7K2ZFC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_17460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000815">
        <property type="protein sequence ID" value="MYW31018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512006.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000815.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW31018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="382" mass="40682" checksum="E5667B8A40C73511" modified="2021-04-07" version="1">MPLTPEDVRNKQFTTVRLREGYDEDEVDAFLDEVESELTRLLRENEDLRAKLAAATRAAAQNQQQQQQQGMRKPPEQQDRPGAPVPAAISGPPQQQQPPQMGPPQLPGGAPQLPAGPSGHGPQGGHGGPQGQGPMQGGPMGGPMGGPMGQHPQQQQMQQMQQMQQPQMQQQGQGPGGDSAARVLSLAQQTADQAIAEARSEANKIVGEARSRAEGLERDARAKADALERDAQEKHRVAMGSLESARATLERKVEDLRGFEREYRTRLKSYLESQLRQLETQSDDSLAPPRTPATASLPPSPSLAPAGAGAMGHSMGSSNHGGHGGQQMGGGQSMGGAPSYGGQQQMSPAMTQPMAPVRPQAPQPMQQAPSPMRGFLIDEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFG4</accession>
    <name>A0A7K2ZFG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_18005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000856">
        <property type="protein sequence ID" value="MYW31117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="263" mass="26580" checksum="9B15CB7DF6D6E7C5" modified="2021-04-07" version="1">GTIGALFGTPIAAALILSESLASQPGPGAFWDRLFAPLAAGTAGALTMSLLAEPSFDLSLPAYSGPHWGDLLSALLIASAGALLGMVAVYAFPVAHRAFQALRYPVLALTAGGLVLGLLGALGGHLTLFKGLDEVKEIAADPDGWSAGEFAVMAVVKMAALVIAATCGFRGGRIFPAVFAGVALGLCAHALVDAVPPALAVSCAVLGVLLAVTRQGWVSLFTAAVLVSDASVLPLLCAATLPAWLLVTGRAQMQLDEEGKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFN4</accession>
    <name>A0A7K2ZFN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="302" mass="31696" checksum="56A2152948D82B76" modified="2021-04-07" version="1">MQRTADGHSGYAAELAVALAAAEEAGRMLRGRFGDVWRIGVKGEDGDVVTELDLAAERIVLDRLREGFPEDRVWSEEAGILAGAADRTWLVDPLDGSNNVAVGLPVYAVGIGLCVEGAPVLGVVHEPHTGVTWHAVRGGGTHRRGGGPDGGAERPAPAPEAVTVAGVPLPDTPVPASAPRLVVAWTQGHSVRKDDPVASALRIALERQTRRVLALWAPLIGWSMLARGTIDGFVGYCAEAVDFPPGALLAREAGCEFRTLEGGPFRIGFTGPDTTRCFVAGRPDVIDRLVALTREATGASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG03</accession>
    <name>A0A7K2ZG03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000879">
        <property type="protein sequence ID" value="MYW31293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="15899" checksum="EB024ED37FAC39BF" modified="2021-04-07" version="1" fragment="single">MPLPAEHIPPGTADWRTPDAERWLAAVPARWAHPLWAVLALVVSMFWYMGEALDPCTSAEPCGTDWSGLGMTVVLVVTPYWVWRQPRLALVGLAAGLVGFAEDGGFTASFGEPYALAYPVAAAFTTAGIVHRLTLAGRQRALALEAAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG54</accession>
    <name>A0A7K2ZG54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000904">
        <property type="protein sequence ID" value="MYW31343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="82" mass="8317" checksum="E17F405DF308E240" modified="2021-04-07" version="1" fragment="single">GIGFYGRGWTGVTQSAPGGTATGPAAGVEPGNQYYKVLKTTCPATGTVGGTAYAHCGNDWWSYDTPATVGTKMAWAKSQGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG89</accession>
    <name>A0A7K2ZG89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">holA</name>
        <name evidence="2" type="ORF">GT040_19070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000888">
        <property type="protein sequence ID" value="MYW31315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="31469" checksum="D0200CD302FC10A0" modified="2021-04-07" version="1" fragment="single">MATRKNSTDDPLAPLTLAVGQEDLLLDRAVQQVVAAARAADADTDVRDLASDQLQPGTLAELTSPSLFAERKVVIVRNAQDLAADTVKDVKAYLGAPVEEITLVLLHAGGAKGKGLLDAARKAGAREVACPKTTKPAERLSFVRSEFRTHGRSATPEACQALVDSIGSDLRELASAVSQLIADVEGTIDEAVVGRYYTGRAEASSFTVADRAVEGRAAEALEALRWSLSTGVAPVLITSALAQGVRAIGKLSSARGGRPADLARELGMPPWKIDRVRQQMRGWTPDGVASALRAVAAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGC6</accession>
    <name>A0A7K2ZGC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000910">
        <property type="protein sequence ID" value="MYW31390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="364" mass="37324" checksum="2BA44EEA5728CA1C" modified="2021-04-07" version="1">MRITQDFAPSGPQGPGSGRTFGRRPVRGRAGAALTATMALALLLTGCGGGNDSASARPKGAQSSADADRVEPLAAAPAPKLPVTVDSADGTKVMVDSTDRIVPLTGSLSEIVFTLGFGKQVVARDITATFEQAEKLPVVTRAHDVSAESVLSLKPTVVLADTTTGPSEAIDQIRDAGIPLVVVEPAKELADVGRRIDTVAEVLGVPAAGTELKKRTESRIAAVQKTIPDHADGKKPRVAFLYLRGSASVYLLGGAESGASSLLEAAGAVDAGKTSGLNKDFTAITSEALAKAAPDAILLMSKGLDSVGGMDGLVKIPGIAETPAGMDRRVVSIDDGVLLNYGPRTDRVLAEIVEQLYPKGGKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGD3</accession>
    <name>A0A7K2ZGD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000914">
        <property type="protein sequence ID" value="MYW31423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="20166" checksum="1B5F4FACC9B61A84" modified="2021-04-07" version="1">HSAIGLLVAGATPAEGLRDRWGAVLRKLAGRDTVAGIIRGRATRLLLDEGRLTEDEAARLMGLALSPGTPPTDAAAWIEGFVGGASGGGMLLVHDERLLSLVDAWLTGVPADTFTDVLPLLRRTFSAYEPGVRRTLGELARRGPVPEGARNDGPDHAYPGFGPGLDQERADAMEPVLHLLLGRTPVPAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGF6</accession>
    <name>A0A7K2ZGF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000914">
        <property type="protein sequence ID" value="MYW31422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="259"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="435" mass="46123" checksum="B6F1BBE002AC2FF2" modified="2021-04-07" version="1">MTAHATRHATQDHATHDHDRTGKTVNTETAAETARPSAPPADGERMRRWRMVLGADSAESTGCTLTGQDVAMDGALNALYGGGGGKKPGGRGGGGRSAGLGASAPSVARWLGDIRTYFPSSVVQVMQRDAIDRLGLSALLLEPEMLEAVEADVHLVGTLLSLNKAMPETTKETARAVVRKVVDDLEKRLESRTRATLTGALDRSARISRPRHRDIDWDRTIRANLKNYLTIPGTDGGPDTGTVVPERLIGYGRASQSVKKDVILCIDQSGSMAASVVYASVFGAVLASMRTLDTRLVVFDTAVVDLTDQLDDPVDVLFGTQLGGGTDINRALAYCQSKITRPADTVVVLISDLYEGGIRDEMLKRVAAMKASGVQFVTLLALSDEGAPAYDHEHAAALGALGAPAFACTPDLFPDIMAAAIEKRPLPIPDKETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGY5</accession>
    <name>A0A7K2ZGY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000972">
        <property type="protein sequence ID" value="MYW31614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018775">
        <property type="entry name" value="RlaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34817">
        <property type="entry name" value="PTHR34817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10127">
        <property type="entry name" value="RlaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="28299" checksum="53761B5D6B4EBB79" modified="2021-04-07" version="1">MNTSPLTLARAGLPVADLRPDLAHAPGPLVFATVSGAHLYGFPSRDSDVDLRGVHVLPAEDLVGLHQPEETRTRMWERDGIEMDLVTHDLRKFVRLMLRPNGYVLEQLLSPLVVHTSGLHAELAALVPGVLTRNHAHHYRGFAGTQWRLYAKTGELKPLLYTFRALLTGIHLMRGGSIQAHLPTLLGEVEAPAYLPGLIEAKAETEHAAATDLDGGAVARDIEELHRVLDEAQEGSRLPEAATALEDLHDLVVRARLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH75</accession>
    <name>A0A7K2ZH75_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpC</name>
        <name evidence="10" type="ORF">GT040_21065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000992">
        <property type="protein sequence ID" value="MYW31700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW31700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="27878" checksum="11798909B3DF58E7" modified="2021-04-07" version="1" fragment="single">MSVLDEIIDGVRADLAERQARVSLDELKERAARAPQAKDGVAALRGEGVTVICEVKRSSPSKGALAAIADPAALAADYEAGGASVISVLTEERRFGGSLADLEAVRAKVDTPILRKDFIVTSYQLWEARAYGADLALLIVAALDQEALVSLIERAESIGLTPLVEAHDEEEAERAVDAGAKIIGVNARNLRDLKVDRSTFERVAPEIPDHIVKVAESGVRGPHDLIAYANAGADAVLVGESLVTGRDPRAAVADLVAAGAHPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHA7</accession>
    <name>A0A7K2ZHA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000995">
        <property type="protein sequence ID" value="MYW31705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="32370" checksum="AE2431CAFA00BA70" modified="2021-04-07" version="1">MARERSGRTAQHLVLVARLRHLREGAGLSVPQAAKLLGWHPSTLRRLEQAQTSLDVGQVSALLDRYGAGASETDDIMGRLNAANMPGWWHPWRDAMDPWLMDLMSVESAASIVRTWDPALVPLLLRTPAYAMAVDAALRPGLDPAVRRRRADLLVMRQRRLREQQARVWAVLPVTALRSRVGDGEVMREQLAALQEAAERRDVMVQLHAEDAPPHPLTGVPALSQYRVEIREIADHVVREGGLPGTAEVWDSGPPVQEYQAMLDVSCVMAMRPDRTREVLQDEYDRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHA9</accession>
    <name>A0A7K2ZHA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001013">
        <property type="protein sequence ID" value="MYW31741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561350.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001013.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="28709" checksum="3685B6759DE86CD6" modified="2021-04-07" version="1">MNFRDLVYRLYARRVEGRLDHDQVPKHIGVILDGNRRWAKASGGSAVQGHQAGADKISELLGWCSETDVEVVTLWMLSTDNFDRPEHELKPLLGIIENTVRNLAADGRWRVHHVGTLDLLPAETQTVLKEAEQSTSHVDGIIVNVAVGYGGRQEIADAVRSLLLEHSERGTTFEELAEIVSTDLISEHLYTRGQPDPDLVIRTSGEQRLSGFMLWQSAHSEYYFCEVFWPAFRKVDFLRALRDYAARHRRYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHC0</accession>
    <name>A0A7K2ZHC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001000">
        <property type="protein sequence ID" value="MYW31715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="10644" checksum="E506F63356271A26" modified="2021-04-07" version="1">GRTGGSAPGALGVLDRLKGRAGARLSGPVVTLDEPAPDPTAVRTPDRPSVISGDLVVRTGPDMRLRTGGQVPLLVDLAHLYVFDHYGRRICPLPQDVPGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHC3</accession>
    <name>A0A7K2ZHC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001012">
        <property type="protein sequence ID" value="MYW31737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8129" checksum="069D7634F4880FC7" modified="2021-04-07" version="1" fragment="single">ARTLGFAADQGVRAVLTNAVRYADPGQGPIADVLDSARRLVPVDPRRSPLDSGERWLKGEDAMREAAERIASAAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHE0</accession>
    <name>A0A7K2ZHE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020246">
        <property type="entry name" value="Uncharacterised_SCO3924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17260">
        <property type="entry name" value="DUF5326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7709" checksum="E977A8DE20717286" modified="2021-04-07" version="1">MREIVAGMPWWVKWIAVPVIAIVVFGGLIASVLSFVISLLFKVLIFVVLVGGLIFVVRKFTSSSSSRGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHK3</accession>
    <name>A0A7K2ZHK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoadipate enol-lactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001021">
        <property type="protein sequence ID" value="MYW31817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="59"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="16193" checksum="5D3CF0FCC46C1EA4" modified="2021-04-07" version="1">TPATPFAPLAEIAPAPDEPEAAGPQRESRHERGVKVRREVLGDAHVDAVNASADPFTEDFQELVTRYEWGEAWSRDGLDRRTRSCVTLTALVASGHLEGLAAHTRAALRNGLTPAEIKEVLLQSAVYCGIPAAGAAFAIAQSVIQEETTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHZ6</accession>
    <name>A0A7K2ZHZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001035">
        <property type="protein sequence ID" value="MYW31879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="16604" checksum="8DEA09C0F2634D3D" modified="2021-04-07" version="1">GDGAPALLAEGIGSPVAAVRERAVRSLAVLPGGEAAGHLREALAHPDPVVRGHAALAIGARGDTDAVPALVDLLEEGRNDTDAADTLSVLASDTATADRIAHRLVERLARSTTRAPARGRLTQALGGIPGTRASQALAELSHDAERAVALTATYLLHLRDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZII7</accession>
    <name>A0A7K2ZII7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="6764" checksum="9C57DE59D9F97C2F" modified="2021-04-07" version="1">MIALPLFLLAGGATWLFWRSDMRAGVLIAALVCGYALATSPLANAIDGIGTGIGAAISNANDSAAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIK5</accession>
    <name>A0A7K2ZIK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="13330" checksum="2583587E78C1533D" modified="2021-04-07" version="1">MNTISRPAAGLATENFDAETLALLEAVEVPLPDFGGLDLDVAFGMPLEMFEAGALPHERLDGLDITAAVAAIEARENRMLAARDIVATDPTATELVRERLVDVLLPYAAQLRITRPAAAAPLPIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ00</accession>
    <name>A0A7K2ZJ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001118">
        <property type="protein sequence ID" value="MYW32249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="35465" checksum="5923EC4FDB075033" modified="2021-04-07" version="1">MTTTDHLVETVTSLVEDAVTAPSMHNAQPWRFVHRAGTRVLTLYGDPSRALPAGDPDGRGLHLGCGAALFNLRVSAAHHGWDAAIELLPDPRDPWHLADAVLQEPGPAEPGPADLYPAVRQRHTSRFPFSDERIPGEIVDGLRGAALLEGCRLIVPGSWHSDAVLDLVRDAALFESADAALREEIASWTHTGRPGEGPATEGIPSYALGPRQYGVSAPARDFDAPRDLPGRAVAAFETRPQIALLGTMDDSPADWLRAGQAMERVLLQATLDGLSTSLMSQPLEWPELRALTREPGSLTGFVHMVFRFGYGPRGVATPRRPVGEVLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ04</accession>
    <name>A0A7K2ZJ04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001149">
        <property type="protein sequence ID" value="MYW32328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="92"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="260"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="327" mass="34290" checksum="5815B9769CE5EFFB" modified="2021-04-07" version="1">ERLRDRPAPASVVVGDSEDRVELQSLGTGRRARGALAVGTGAALGTAERYAVHSAVALLTLTTARSRSLQGAEQRLGAAVLRMLLAGQPDHARAVAGDLYGGLLDAPFRLLIAEAAAPAGFDLLTETMEAAAARSGEALLMVPEGERVVVLAADGGTAVAACASYAEAQDDRAPREGGAEDSDVVVGLSAPCGPIAVSAAYKQAEQALSVARRRGRALVEHEELAAGSVLPLLADDAVRAFADGMLRALYEHDAKGRGDLVASLRAWLSRHGQWDAAAADLGVHRHTLRYRMRRVEEILGRSLDDPDVRMELWLALKATEAATPSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ82</accession>
    <name>A0A7K2ZJ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001163">
        <property type="protein sequence ID" value="MYW32420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="12293" checksum="C064CA9B3D23F5D2" modified="2021-04-07" version="1" fragment="single">MSTKDFVEKDYYKVLGVPKDATDAEIKKAYRKLAREFHPDANKGDAKAEERFKEISEANDVLGDTKRRKEYDEARALFGNGGFRAGPGGAGGNFNFDLGDLFGGGAPGGGQGGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJZ5</accession>
    <name>A0A7K2ZJZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001216">
        <property type="protein sequence ID" value="MYW32663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="33259" checksum="EC44917803BF3458" modified="2021-04-07" version="1">MTHEAAGVPPTRNDDDRQDDDRPAEPQQPAPEGAASAGDAAPRPEARLAKAVQAAEQALIEFEIAVETFRVEVENFSRLHHQKLGPMYARLDELDAQIAEARAAKTGDPEDLRKAKEARDIVMPMPGVDELFHDWMDGDGLSPEASAMLTEQPVRPPKRVRPSEEARKLYRELARKAHPDLAQDEPERERRDEFITRVNAAYGRGDVELLKELAAEWAAGPAQPLAPLSESEELYARLEWLSRRKELLTVLAKELEEGAIGSMLRMAPDDPDQLLEDIGEQLLGEVSRREAELAEMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK02</accession>
    <name>A0A7K2ZK02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoacid:acceptor oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_26235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001221">
        <property type="protein sequence ID" value="MYW32676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="55"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="298"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="553"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="654" mass="69790" checksum="8998003D2DCDE63F" modified="2021-04-07" version="1">MTSQVSSAAEKADEANDAVLGGQRAPLSGTTGTTEGDGKEVRRLDRVIIRFAGDSGDGMQLTGDRFTSETASFGNDLSTLPNFPAEIRAPAGTLPGVSSFQLHFADHDILTPGDAPNVLVAMNPAALKANIDDVPRGAEIIVNTDEFTKRPMAKVGYATNPLEDGSLEAYNVHPVPLTTLTIEALKEFGLSRKEAERSKNMFALGLLSWMYHRPTEGTETFLRQKFAKKPQIAEANVAAFRAGWNFGETTEDFAVSYEVAPASQAFPTGTYRNISGNLALSYGLIAAGQLADLPLYLGSYPITPASDILHELSRHKNFGVRTFQAEDEIAGIGAALGAAFGGALGVTTTSGPGVALKSETIGLAVSLELPLLIIDIQRGGPSTGLPTKTEQADLLQAMYGRNGEAPVPIVAPQTPADCFDAVIDAARIALTYRTPVFLLSDGYLANGSEPWRIPETDSLPDLTTPFATGPNHTLADGTEVFWPYKRDPQTLARPWAIPGTPGLEHRIGGIEKQDGTGNISYDPANHDLMVRTRQAKVDNIEVPDLVVDDPAGAATLVLGWGSTYGPITAAVRRLRAAGQPIAQAHLRHLNPFPSNLGEVLKSYDKVVVPEMNLGQLAMLLRAKYLVDAHSYNQVNGMPFKAEQLATALKEAIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKA3</accession>
    <name>A0A7K2ZKA3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_26710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001249">
        <property type="protein sequence ID" value="MYW32765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="12997" checksum="3C79707DE929CF57" modified="2021-04-07" version="1">MSEKTQGNTHDDDKLPIRMLHDRVLVRNDTAEGERRSGGGILIPATAAVGRRLAWAVVVAVGQNVRTVEPGDRVLYDPEDRAEVEVRGVAYVLMRERDLHAVAADRFEGSVDSTGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKH4</accession>
    <name>A0A7K2ZKH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001258">
        <property type="protein sequence ID" value="MYW32833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="463" mass="48551" checksum="DE99C637B7B06C61" modified="2021-04-07" version="1" fragment="single">MTLLDVLLGAVREAPGQVVVHVRGDGSELTVTLRELLDDALHVAGGLRETGVVPGTCLPLLADRSEDFQPMFWGALAAGLVPVPLAPDARRILPVWEHLGRPPVLVDAANGPVAGELAGGVRVLRLDVLRQGPLLREPVVAGPDDVAFVQFSSGSTGAPKGVEVTHRSVLANLEQIRAASALAGDDVLVSWMPYFHDMGLIGTHLAPLAARAKQVKIGPLSFAKRPRIWFEVADRHRATVLSAANFALALAVRRVPDEVVARLDLSAVRLMLVGAEPIAPVVWREFARTMRPAGLDPAAAQPVYGLAEATLAVTFPPPGEVAEPLVLDREALSRGVAVDSVVDSVVDSGVGSVAGEGAVELMDVGLPVAGCAVRIVDDGGAELGDRRVGHILVSGPQLARGYHGLPGVSADVFADGWLRTGDLGFLRDGRLCVTGRHKDVLFLNGRTFHAPDMEAVAAATPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKP1</accession>
    <name>A0A7K2ZKP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_27390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001276">
        <property type="protein sequence ID" value="MYW32898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="22501" checksum="81C090E78A411EBE" modified="2021-04-07" version="1" fragment="single">MRIPAHSVCTAIRDEIVSGVYERGSRLTEELLARRYGVSRVPVREALRTLESEGFVVTRRHAGACVAEPTEQEAADLLEVRMLLEPLGAARAAQRRTEAHLKVLRGLVRLGQERARRGEGEDLRSLGGWFHDTLAQASGSPGLIALLTQLRHKIAWMYAVEQPARPADSWAEHGAIVDAVARGDAERARALTAQHAERAAGAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL71</accession>
    <name>A0A7K2ZL71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_28445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001315">
        <property type="protein sequence ID" value="MYW33095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029709935" evidence="6">
        <location>
            <begin position="36"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="58"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="160"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="406" mass="40423" checksum="588B2562D030B6EB" modified="2021-04-07" version="1">MAAVRTTKRRIAGAIAAATTLALAVGAGAALPAQAAPAPAPEGRVLHAGAAGAVPGSYIVTLKETAGFGASATQGKKLIAGYGGQITRTYTSALNGYAAKLSSTEAKRLAADPAVASVEQDRQVHSTATQTNAPWGLDRIDQPNLPLNGTFTYPDSGGGNTTVFVLDTGVRITHQDIAGRASYGWDFVDNDATAQDGNGHGTHVATTAAGTTYGVAKKAKIVAVRVLDNSGSGTTAGVIAGVDWITANRTSSSVANVSLGGGASTTLDDAVRRSIAAGVTYAIAAGNSNALASNYSPARVDTALTVGATTRTDARASYSNYGPRVDLFAPGSDITAGWATSDTATYTGNGTSFAAPHVAGAAAVYLTNHPGASPAAVGAALVNGATNNVLTGIGSGSPNKLLRLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL72</accession>
    <name>A0A7K2ZL72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_28485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001317">
        <property type="protein sequence ID" value="MYW33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="334" mass="37263" checksum="8B2A5BD4AF319152" modified="2021-04-07" version="1">MATSTPTRDAHTTPPREPQKEPPSERRQLWRSRLWRFDDKASPYAYIAPFFLIFGAFGLYPLLYTGWIALHRVSMTGLDSMEWVGWENFDKILHDPEFWTSVSNTFLIGVISTVPQLLVALGLAHLLNYRLRASTFWRTIILTPYATSVASAALVFALVFRADGGLLNWTLGLVGFDPVNWANGHWTSKLAISIIVIWRWTGYNALIYLAAMQAVPNDLYEAASLDGASRWQQFRKVTIPSLRPTILFTIVISTIGSMQLFGEPLLLEGGAMGATGGNENQYETLSIYLYNYGWNLGHLGPAAAVAWAMLALLLLIAGVNWLIGRYVRTSDSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL89</accession>
    <name>A0A7K2ZL89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hybrid sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_27985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001303">
        <property type="protein sequence ID" value="MYW33009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="66"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="33139" checksum="680E66C8AD5CCEEA" modified="2021-04-07" version="1">RAQREELRRLNDELEETNRGVLALYTELSQELEETNSGVVALHTELEEKSHRLRETSEAKTRFWTNISHELRTPVNAVVALSRLLLAAGSAPLTEEQRRQVSLIDASGQTLFSLVNDLLDMAKAEAGQLEIAAAPVDLRALVGQLGAVMRSTGMPDGVVLVTPGPGTLPVAVTDEALLTRILRNLLSNALKFTEKGEVRLEFAVDPEAAGAWMTFTVADTGVGIPESELKRVFEEFYQVRGPLQRAHRGTGLGLPYARALTELLGGTLRLSSTPGVGTRVEVRLPHRPGPASAAPPAPPAPSAPEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLC0</accession>
    <name>A0A7K2ZLC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001336">
        <property type="protein sequence ID" value="MYW33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="1">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16672" checksum="7F21294FB9D2F6D1" modified="2021-04-07" version="1" fragment="single">RARDEVAAVWRVAELPSRHGRDTGQIIEAAATGELGALLVAGVGVEDLPDPARALKALDEVGFLVSLELRPSEVTARADVVFPVAAVAEKSGTFLNWEGRVRMFQAALKPEQMPRTLAPVDSRVLHMLADAMDVHFALPDLTAARRELDRLGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM47</accession>
    <name>A0A7K2ZM47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001387">
        <property type="protein sequence ID" value="MYW33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6474" checksum="2CC57EC6D04A1C7E" modified="2021-04-07" version="1">MTEQGTPPFYVPVAVLLLVAAVVVSVIAGDAHSGVRTAAIIAGGAIAVGLAFYKARSILKKCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMS5</accession>
    <name>A0A7K2ZMS5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">galT</name>
        <name evidence="16" type="ORF">GT040_31465</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="WWKE01001440">
        <property type="protein sequence ID" value="MYW33664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="194"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW33664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="347" mass="38742" checksum="D6CA2D520E069C57" modified="2021-04-07" version="1">MKKTVTRLADGRELIYYDSADGTVRDAVDRRPLDAVSTSSEIRRDPLLGDAVAVASHRQARTYHPPADSCPLCPTREGRLSEIPDSHYDVAVFENRFPSLAGDSGRCEVVCFTSDHDASFADLTEEQAALVLAAWTDRTAALSALDQVTQVFCFENRGAEIGVTLGHPHGQIYGYPFVTPRTELMLRSAARHREETGGNLFDDVVAREEKEGNRVVLATDHWIAYVPYAAHWPYEVHLHPRRRVPDLPALDEAARTEFPQVYLELLRRFDRIFGPGEPPTPYISAWHQAPFGVDGRDEFALHLELFTIRRTSGKLKFLAGSESGMSVFINDVPPEAAAERLREVASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMT1</accession>
    <name>A0A7K2ZMT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001440">
        <property type="protein sequence ID" value="MYW33666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10436" checksum="0BDD543B491E17AB" modified="2021-04-07" version="1">MSDLHKEVSELERKSATAARLFDIRRIIGGLFVVYGVIVTIAGISPSDADLEKAEGVHINLWTGLAMLALGLFFLVWMKLRPAEAPAAPVEETDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNL5</accession>
    <name>A0A7K2ZNL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LmeA family phospholipid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001502">
        <property type="protein sequence ID" value="MYW33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029860858" evidence="1">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="23904" checksum="A402E482798F2CBA" modified="2021-04-07" version="1">MRALRILLVLLVVVGALFVAADRLALHFAESEAEDRVRISGGSAGTTEVSIKGFPFLTQLAASEFDRVDVTLKDMKTEAAGRAIRVGEVRAQLHDVKLGSGYSSATAARATGTAVVSYADLTAAAEDGVTVAYGGDGKVKVTGTVEILGRPISRSVVSTVTRVDGHTIKVRADEVPGEGIPGVEQLVRTRTDFEGDIDGLPKGLELQKVQVTESGLEIALDGSDVSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNX2</accession>
    <name>A0A7K2ZNX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase</fullName>
            <ecNumber evidence="5">2.7.7.42</ecNumber>
            <ecNumber evidence="5">2.7.7.89</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_33425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.42" evidence="5"/>
    <dbReference type="EC" id="2.7.7.89" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001538">
        <property type="protein sequence ID" value="MYW34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047388">
        <property type="term" value="F:[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="3">
        <location>
            <begin position="89"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="4">
        <location>
            <begin position="337"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="536" mass="58811" checksum="AC337B3925B50A74" modified="2021-04-07" version="1" fragment="single">MTTVPGRRSSTFTRLLRHGFTDPSAAEQLLDLDDLASVRSDPVLLEALGATADPDLALRGLVRLVEAEEEGERQVLLDTLVTAKPLRDRLLGVLGASEALGDHLARHPRDWQALVTYEAVDLHPGVAEFERGLAEAVDPDSLRVAYRRCLLTLAARDVCGTTDLAQTAAELADLATATLRAALAIARTAAPEDAAQCRLAVVAMGKCGGHELNYVSDVDVIFVGEARDGVDENKAMQAATRLAAHMMRICSDNTPEGTIWPVDANLRPEGRNGPLVRTLTSHLAYYQRWAKTWEFQALLKARAVAGDPELGQEYVDAVSPLVWQAADRENFVPDVQKMRRRVVDNIPADRIDRELKLGPGGLRDVEFAVQLLQLVHGRSDASLHSGTTLEALRALAEGGYVGRADAAQLDEAYRFLRSMEHRIQLYRLRRTHLVPEDEADLRRLGRSLGMRTDPVAELNKAWRRHASVVRRLHEKIFYRPLLDAVAQLAPAESRLSAKAAAIRLEALGYADPGAALRHLEALSSGVSRKAAIQRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP11</accession>
    <name>A0A7K2ZP11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="32"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="36773" checksum="E201B84C141C0A9C" modified="2021-04-07" version="1">MSSVPPPGLDPELLRGHLDRERPGLVSGPLEARLIEGGRSNLTYTVTDGTGRWVVRRPPLGHVLATAHDMKREHRVISALHPTAVPVPEPVLLCEDDAVLGAPFYVMEHIEGTPYRTAEQLAPLGPERTRAAVLALVDTLVDLHAVDPEAVGLGDFGRPEGFLDRQLRRWGKQLDASRNRALAGIDELHASLGRELPASPAPTVVHGDYRLDNVLLGPDDRINAVLDWEMSTLGDPLTDLGLLVMYSSDLDLPHSPVSTTSGAAGHPSPAELIERYAAGSGRDTSAISWYTAFAWFKLAVILEGIHYRYTLGQTVGAGFDQIGDLVPVFIEHGLTTLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP34</accession>
    <name>A0A7K2ZP34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001544">
        <property type="protein sequence ID" value="MYW34105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="28830" checksum="4F84901B7DEBDF60" modified="2021-04-07" version="1" fragment="single">MPASPSTARAINDRLALQLLQQHGPLTATQLKTLTGLSRPTVADLVERLQGAGLIHVVGESGAVRRGPNAKLYGIVADRAHLAALDVRTGSVSVVVADLLGATLAEATLPIADGTGTGPAVDQAVALLERTAREAGSVPLHSVGIGAPGLIDPASGELRDSSGLPAWHRSLVRVLQQRLPATVLVENETNLAAVAEHRAGAALDRETFVLIWLGQGIGAAVMLDGKLRQGASGGAGEIGFLPVPGVAGLPSAVDCEGGFFSLAGSAAVRELAARHGIAGEGPTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPE0</accession>
    <name>A0A7K2ZPE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_34385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001575">
        <property type="protein sequence ID" value="MYW34226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="168" mass="17009" checksum="0C76A542E821D37A" modified="2021-04-07" version="1" fragment="single">VTAAGAVAGVLLPLGAVTGLLLIDPWTAAAFLLGAPLLVALLHTFTRRTADAGADYQRTQSVIAHRLTEALDGADTIRAARTGAREYRRILEPLGALADHGRRTWTVYGRAAGQSALLLPLLMLLVLAVGGLRLGAGAIGVGDLVAASRYAALAVGIGALTGALGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPZ3</accession>
    <name>A0A7K2ZPZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001615">
        <property type="protein sequence ID" value="MYW34405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="16102" checksum="624789F969EE2106" modified="2021-04-07" version="1">GVGQGTFYRNFPHREALVLEIYRYEMQQVADAAGELLSTREPEAALREWMDRLAGFAMTKAGLADAIRLVTSAPGGPAKPGPAPVLEAAGTLLRANEEAGTIRPGVTPDDFFLAIAGLWQLDPQEEWEPRAARLLDFVMDGLRAGAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQA1</accession>
    <name>A0A7K2ZQA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_35795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001629">
        <property type="protein sequence ID" value="MYW34497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="104"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="367" mass="38792" checksum="D32A125D2BC570A3" modified="2021-04-07" version="1">MSEQKKTPGRIRGTGTRRRKPTRRKRAKAVTAWTVAGVVVVGGAGLGYAYVTLDGNLSSIDIDAKLGTDRPDDVDDGSQDILVLGSDSRSGDNGKYGTDEGAARSDTAMVLHVDKGHKSASVVSIPRDTLIERPSCASDTTDETVPAEHRAMFNTAYEVGGPACAVKTVESMSGIRMDHYVEVDFTGFEKLIDELGGVEITTKTAINDSKSHLDLEPGTHTLDGEESLGLVRTRKSVGDGSDLGRIQLQQAFIKALMEQAKSVGVFSSPKKLFGLADAATKAVTTDSGLGSVKKLTGFANGLKGLGADNVHMVTLPVEYDPADPNRVLPQEKAGKQVWAALKQDRPIPASATEKSAGDKGDAGQVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQH1</accession>
    <name>A0A7K2ZQH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001641">
        <property type="protein sequence ID" value="MYW34567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="170"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="351" mass="38060" checksum="8D435FBA5EB4830A" modified="2021-04-07" version="1">MKIEKWVVREHVEGVPDVDRVYEKVVENVDVTLAPDEMLLRTLYVSVDPYLQGIALDTPIGTHMGADSIMEVVEAGPRAAHGVGDLVQGFGGWRSHVVSTGEAELWQTGTFPMVFPAYRRLDPQWYDDALPLPTALSVMGGPGMTAWGTLAKYMTVTPGDTFVISGASGAVGALVGQLAALAGARVIGTTSSPQKAEYLLGLGFDTVVVYRHTDSAGTVREALTRAAPGGVDRYFDNLGGTVTDVVFSMLNVGSQVAVCWQWATQVGNEDTGPRLLPYLMFPRATVRGIFSLEWFTEQNWKDLHAELGGRVRRGEVVCDHTLHHGFDAIPAAYGSLYRDRSDHRGKVLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQK8</accession>
    <name>A0A7K2ZQK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_36070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001637">
        <property type="protein sequence ID" value="MYW34549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="96"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="371" mass="40100" checksum="D45F029B9188230E" modified="2021-04-07" version="1">MPTTLTTDRPRATTLFRPATTVLGHQERQVLSAIGCGLRDDEIAAELGVPEDTVSEHLARILVKLGLRDRAAAIVHAFDCGLAVPGRGPRIRSAGPASLTVAARAPGPAPKVRISLLGPVRAWRDGRLLDLGHLRQQAVLAALSLGTGRSLSQQQLLDDVWGMEPPVTNVVPVYVYRLRKALHDGAGPRTVIERGLRGYQLVPGAVDVDVTHLRELATGIGKAARAGEPLEAVRLCAQALKLFHGEPLAGLPGPLAELERLRLTERRIAIVRRKVEWQLRLGQDDEVIDELFALTAAHPVDEPLAAMLMRALYRDGRQAEALTVFERARRRLADDLGVSPSRMLRRAHQMILRGDEAGLGPTPPVGAGTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQW4</accession>
    <name>A0A7K2ZQW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phoU</name>
        <name evidence="5" type="ORF">GT040_36965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511067.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001681.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="24980" checksum="87B179259F2E3F9B" modified="2021-04-07" version="1">MRDAYHEELDSIGEGLVEMARLVGSAIGRATTSMLDADLKLAESVIAGDQKVDDLQHDLEARAIALLARQQPVATDLRIVVTSLRMSADLERSGDLAQHVAKLARLRFPQSAVPHDLHATILEMGQLAQRLMAKAAEVIITKDVDLALQLEQDDDEMDLLHRTLFQHLMDDRWKHGIETAVDVTLLGRYYERFADHAVSVAKRVVYLVTGEHADEIQAATTPAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR47</accession>
    <name>A0A7K2ZR47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001697">
        <property type="protein sequence ID" value="MYW34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037664301.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001697.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="76" mass="8031" checksum="1F00B2EA6B3FE243" modified="2021-04-07" version="1">MSQQPAPAPARQPLDEHAAESVLAYAAAERAKTDVLASVLEDIAANGYPAPESGVPWETARDAHLARLADEQPRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRH2</accession>
    <name>A0A7K2ZRH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_38140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001730">
        <property type="protein sequence ID" value="MYW34946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076965488.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001730.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="189"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="397"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="547" mass="60712" checksum="5CD96B1331B71B89" modified="2021-04-07" version="1">MTGPLIVQSDKTLLLEVDHELADACRRVIAPFAELERAPEHIHTYRVTPLGLWNARAAGHDAEQVVDALVEYSRYPVPHALLVDIAETMARYGRLTLSKHPVHGLVLTSTDRPVLEEILRSKKVQPLVGARIDPDTVAVHPSERGQIKQTLLKLGWPAEDLAGYVDGEAHPIELAEDGWALRPYQRQAVEGFWHGGSGVVVLPCGAGKTLVGAGAMAEAKATTLILVTNTVSARQWKHELVKRTSLTEDEIGEYSGTKKEIRPVTIATYQVLTTRRKGIYPHLELFDSRDWGLVVYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDSERLAYATAEAEEKYRFCATTATKRKVTEALVRKHQGEQTLVIGQYIDQLDELGEHLDAPVIKGETSNAQREKLFGAFRNGEISVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHEARFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIVDADELLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRJ9</accession>
    <name>A0A7K2ZRJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001726">
        <property type="protein sequence ID" value="MYW34927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="21561" checksum="43BFB297D79DDBF0" modified="2021-04-07" version="1" fragment="single">MSAIAADPGAPETDRLPVLSPMLQRLAAERATGALMRDRGTLYLADGQVVHAESPATPGIDVLLTTGGTLRHEGWWDAVAQAGAGQRVGRYLVDSGHVPGGALELCHLGALYDAAFFALAPTGTPARFRYGVSHWIGPVRPVPVAAVQRETLRRRELLDRIWPDAACDSAPVVRAAAHPGDSPVPARQRAVLELADGVRTASDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRK8</accession>
    <name>A0A7K2ZRK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001728">
        <property type="protein sequence ID" value="MYW34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="420"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="516" mass="56197" checksum="8C425B293195B0ED" modified="2021-04-07" version="1">MNQPPNGFWAQAAADPDRTVLVAPGGEEWSAGRLHTDVNRMVHGLRAAGMSEGDALAVVLPNGTELLTAHLAASQAGFYLVPVNHHLVGPEIAWIVADSGARVLITHERFAAAATAAADEAGLPESHRYAVGTVPGCRPYADLLDGHPATPPEDRTLGWVMNYTSGTTGRPRGIRRPLPGKLPEETYLGGFLGIFGIRPYDDNVHLVCSPLYHTAVLQFASAALHIGHPLVLMDGWAPDEMLRLIDTHRCTHTHMVPTQFHRLLALPDEVKARYDVSSMRHAIHGAAPCPDHVKRAMIDWWGSCVEEYYAASEGGGAFATAEDWLKKPGTVGKAWPISELAVFDDDGNRLPAGQLGTVYMKMSTGGFSYHKDETKTRKNRIGDFFTVGDLGVLDADGYLFLRDRKIDMIIAGGVNIYPAEIESALLTHPAVADAAAFGIPHADRGEEVKAVIEPAEGYEAGDALAAEILAHCEERLAGYKRPRSVDFIAAMPRDPNGKLYKRRLRERYWEGHPRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRL9</accession>
    <name>A0A7K2ZRL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001745">
        <property type="protein sequence ID" value="MYW35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003970432.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="63978667"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6442" checksum="20022CB1959D1B8F" modified="2021-04-07" version="1">MILSISGVVLLAIVVFLFFKKDGLKASHAIVCALFGFYLAGTAIAPSITAGGASLAGLLGGIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSE2</accession>
    <name>A0A7K2ZSE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001796">
        <property type="protein sequence ID" value="MYW35218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="54" mass="6112" checksum="BE10404521586005" modified="2021-04-07" version="1" fragment="single">MTVPRTMHLAAHFPGVNATTVWADPRSRSQIDFSSFVHLAQTAERGKFDFFFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSN1</accession>
    <name>A0A7K2ZSN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="12967" checksum="8A2DFC3D6A7675AA" modified="2021-04-07" version="1">MPATGPDFISFQVRDLDVSQAFYERYLGLVRSQAGPPHAVVFATKPIAFAVREALPGTDLASIPQPGIGAAIWLHATDVQAIHDALAADGHAIVSAPVDGPFGRTFTFADPDGYQVTLHDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z666</accession>
    <name>A0A7K2Z666_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000026">
        <property type="protein sequence ID" value="MYW27840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="25822" checksum="A2681DB22A9E6D38" modified="2021-04-07" version="1">RRLASLPPEAHYPAGGWARLVDRMAGHARGLGAAVETGARVDTRTLGELARTGPVVVATSLDAARVLLDEPSLTWESGRTVLVDLALRTRRGDAFVVSDLDAPGWVERFTAQDPGLAPAGEQLLQGQFPIGPDARKAEGTARAEELLDLGFPGWRQRTTWRTEALADGRTGAVDRPGTTWRDRPSVIRGDGIFLAGDQVAAPGLLSETSFTSGIEAALLAVKAAGRHSGPGAGPGSAQPSGRPSPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z673</accession>
    <name>A0A7K2Z673_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_00785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000027">
        <property type="protein sequence ID" value="MYW27841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029505677" evidence="11">
        <location>
            <begin position="22"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW27841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="364" mass="37678" checksum="C300BE47C9C760DB" modified="2021-04-07" version="1">LAVYAAVRALGLLGLWVAAQASGKDPLARLAGRWDSVWYQRIAENGYGYTVTLPDGALHSDLAFFPLLPALERGISEVTPLTLGGAGLLVAWTAGLLAAWGIFAVGAELYGRRTGVVLAALWGVYPTAFVQSMAYTETLFTALAAWALYAALRGRWLVAGALCVLAGLTRPSAAALIAALAITAAVTLVREIRAGSGPGPVLRRNARMIAGVALAPLGWLAYVVFVAVREGSPFAYFDVQAQWGNSIDGGRALAAFIAGLPLPAALGLCAALGLLGRLVVLCVRQRQPLPLLVYGIAIVVISLIGAGYFGSRPRLMMPAFPLLLPPAAALVRLRGTGRTAAVIAVLACASAAYGAWTLLGAGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z698</accession>
    <name>A0A7K2Z698_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF348 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_00925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000039">
        <property type="protein sequence ID" value="MYW27869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029652246" evidence="2">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="196"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW27869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="29041" checksum="78AD03FF4F9BB397" modified="2021-04-07" version="1" fragment="single">HLKLRRLVPQALVVAFLAGGTTAFVAHDKAVRLDVDGTPRTLHTFADDVTELLADEGVTVGAHDHISPAPGTELDHGDQVTVRYGRPVDLTLDGHHRRVWTTADTVGGALRVFGVRAEGAYLSASPSARIARTGLTLTVRTERTVTFMADGQERTVRTNAATVHEALAQAGITLHGLDTTSVGPTSFPRDGQTVSVLRITDTREVHEESVPYAVERSEDPELFRGIERVERAGRNGVRRVTYAVRTVNGVRQTPRRTGEELVHRPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6J2</accession>
    <name>A0A7K2Z6J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000060">
        <property type="protein sequence ID" value="MYW27961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="31968" checksum="DBC8BF4C7AF61EE2" modified="2021-04-07" version="1">GGVEARATAAVRRFAEDPLLVAAIGATGADAAREALVAYDEAALPLLSVVDGDTRNLNRIFLCARPRNDMQMLPVAQFLGANGLDTVALVDDGTEYGRQTTRFLDAGLRGNGRTVLPETVREGTRDLDAEAERIVAKKPGAVVYGGGWRDAGRFARALTKAGFLGPKIGTQAVHDPRFLAEAGEDAAGWLVVSTAADPASVPSVRPFAAAYRKRFDSAPPLLAAEAYDAVGLIAACAEGLGRESVTRQDMLPVLRSTRYKGVSKSYAFEPANGMYAGNGVFIYRVERGRFRYIGMDGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6V4</accession>
    <name>A0A7K2Z6V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000088">
        <property type="protein sequence ID" value="MYW28071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="46"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="26224" checksum="8309CAD5184DF3C0" modified="2021-04-07" version="1">PALSGILLAPLTTPGAPDAAGAVPRPVTFWPYGTPVDPRDPDAAPWADAAVLLARLHRIVSPLPLPVPPMRGPVKAARAVARMVAALPGDAAVLSVQAAWHALPAWARGEAAPPAARSGFLCHGDLHLGQLVRHPAPDGPWLLIDVDDAGLGDPAWDLARPAAWYAAGVLAPEDWVLFLDAYRSAGGPAVPAEGDPWPQLDVPARALTVQTAAVAFAKCAAEGREPDEMEQLMIDSCARIATFPPELAAGPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6W6</accession>
    <name>A0A7K2Z6W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1254 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000084">
        <property type="protein sequence ID" value="MYW28062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1254" evidence="1">
        <location>
            <begin position="53"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="183" mass="19338" checksum="E0EC747650AF7D8C" modified="2021-04-07" version="1" fragment="single">MPETTGTSSDSTGADLVDLAAEAYVYGYPLVCDLSMVGTSLRDGFGALAAAPFNRFAHSERLADHRTEFVSVNNDTVYSIAQLDLSGGPLRLHVPDSGGAYYVLQFVDAWTNNFAYVGRRATGTAEGEWLIVPPGWAGSAPDGVRGVIDAPTSVVTVAGRYACDGPGDLPRVRALQERLTLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z784</accession>
    <name>A0A7K2Z784_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000113">
        <property type="protein sequence ID" value="MYW28201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="18058" checksum="2B67F884ED631EEE" modified="2021-04-07" version="1">TGSPCALLAGTPLARGFAVGSTTDSADPDAREDIGENGARPRYRQTGCLADLTDPDGALWRLSTTAAVYEDVGPAHHAYRVKEDLDRAHGRGPQRVHDAAYAKPADDQGRPGRTLLLWNGDLLLSVTAYAPYGSKEDEVRDDLGSIVENTARLMEDGLRDRDAPSPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7U7</accession>
    <name>A0A7K2Z7U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family deazaflavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000160">
        <property type="protein sequence ID" value="MYW28424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="161" mass="18181" checksum="CF524EF86F34F712" modified="2021-04-07" version="1">MTGTRGARLIQKVSSTRAFARIAPHVVPVLDRTVHRLTRGRVLPSARMLPGLVLTVPGARSGRLRVTPLACMPEGESESTWILVGSNFGRTGHPAWTANLLARPEEAVISWRGRDIPVRARLLEGAEREEVWRVALTFWPPYAAYQARVERQIRLFRLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7X8</accession>
    <name>A0A7K2Z7X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_03940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000168">
        <property type="protein sequence ID" value="MYW28446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029622586" evidence="3">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylas" evidence="4">
        <location>
            <begin position="42"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="15549" checksum="2645B50E232ECAB8" modified="2021-04-07" version="1" fragment="single">MAANGRHRRYQPSRINRASLTVTAGGAGIALPLITAASAGAASGEVWEKVAACESSGNWAVNTGNGYYGGLQFSGPTWAAFGGTQYAPRADLATRDQQIDIAERVLDGQGPGAWPACSVKAGLTRGGDAPDTTPQSAGTRPVQAAAPQSAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z886</accession>
    <name>A0A7K2Z886_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3048 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000203">
        <property type="protein sequence ID" value="MYW28569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3048" evidence="1">
        <location>
            <begin position="34"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="2">
        <location>
            <begin position="187"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="305" mass="32508" checksum="B112EEB3DC7D4713" modified="2021-04-07" version="1">MLTALLLVLLTAGCTGGDGSEPESRSSSPSDTGADAKVLAVKIDNVAPARPQTGLERADIVYVEQVEAGLSRLLAVYSSDVPPVIGPVRSARETDLELLRQFDRPVLAFSGAQSRLLPAIERAPLDAVPPSAAPRAYFRGAERPAPHNLYLRPERIPYTASGTEAVEALGLRFGPAPPGGSAEDNRTVRFPSARTTFTWSAERERWLVSMDGSPARTSEGEPLGASTVIVQDVAVRPSAFGDRSGNNTPFTETVGSGTAHVLRDGKAYEARWARTAADADTRFSTPDGERIDLAEGPLWIVYAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8B7</accession>
    <name>A0A7K2Z8B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TauD/TfdA family dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_04770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000209">
        <property type="protein sequence ID" value="MYW28597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="4">
        <location>
            <begin position="35"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35840" checksum="22E2074B5F6B0EAA" modified="2021-04-07" version="1">MFTPASAGSRTSGQTLPHLMTAAPGGSAADRLAGARPEIRARLREHGAVLLRGFGDDGVDGFERTVRAIGGEPLTYAERSSPRSTIKGQVYTSTDYPPSEEIFLHNENSYQATWPLTLFFLCVTPPDTLGSTPLADTRRVLAAIDPQVREEFAARGWMVVRNFTDGFGVPWQHAFNTEDRAEVEAYCARNGVVAEWTPGGLRTRARREAVHRHPVTGERVWFNHLTFFHVTTLGPDLCGALREMYEEADLPTNTYYGDGAPVPDEVVAHLRDCYRAEQRRFDWQQGDVLVVDNMLAAHAREPFTGPRKIAVAMAEPSSGPVEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8V6</accession>
    <name>A0A7K2Z8V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000248">
        <property type="protein sequence ID" value="MYW28725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="252" mass="26830" checksum="E54D424BD4D62D34" modified="2021-04-07" version="1">MSEQQLLNGKTAVVAGGAKNLGGLISRTLAEAGANVVVHYHGENTAADAEKTAEAVRGTGARAVVVREDLTRVEGVRSLFDQALDAFGGVDVAVNTTGMVLRKPIGETTEEEYDRMFAINSKAAYFFLQEAGARLNDGGRIVSLVTSLLAAFTDGYATYAGAKAPLEHFTRAAAKEFAPRGIAVNNVAPGPMDTPFFYPQETPERVEFHKSQAMGGRLTEIEDIAPLVKFLVTEGGWITGQTIFANGGYTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9F0</accession>
    <name>A0A7K2Z9F0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_06695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000302">
        <property type="protein sequence ID" value="MYW28969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="30385" checksum="E9AC651D879BCD9E" modified="2021-04-07" version="1">MDAVSYTAQWMAAARAQESEREDPLFVDPLARDLAAPRGFELVERYVGGGVLPFISIRTRFMDDAIKEIVAGSGIQQVVLIAAGMDTRAFRLDWPDGTELYEVDHAALIAEKRRRLDALGAEPRTDRREVSADLTTEWLPDLEAAGFDRGRPTLWVAEGLTFFLTEEQVGGLLELLASASAPGSHLAFDMLGRAMLRSPFSQRFLDALAADDTPWLFGTDEPEEFLTAHGWKTTDLREPGQPGAGEGRWPYEVQPRGRRGANRLWLIRAEVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9G4</accession>
    <name>A0A7K2Z9G4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">vWA-TerF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000304">
        <property type="protein sequence ID" value="MYW28986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="vWA-TerF-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="19489" checksum="9022C1CD668EE61D" modified="2021-04-07" version="1">MRPFYRDGSAQHLGDRAVALAAHLDADATVPVVFFSTDIDGTGTIELAAHEGRVDELNAGLGRLGRTNYHRAVEEIVAHHEKAQDAGPALVIFQTDGPPDAKQLARQALADAARLPLFFQFVAFGEQDGKGFDFLRRLGAPNAAFFQAGPAPREVADAELYRAILAGLPAWLAAREERSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9J6</accession>
    <name>A0A7K2Z9J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000302">
        <property type="protein sequence ID" value="MYW28972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="270" mass="28559" checksum="78A516843DF64960" modified="2021-04-07" version="1">MSGLALRAAASVRSPQGRAPEGVPAALDYFRDLLTPFGEKPDEELLSRGPHVHHRDLVDLLVADEAVGRSRPELAIVAHALPDVVPFTAVAPHLTEQLGGRAVNFAIGQQGLAAPFTALRIASAYHRSGRAAEVVIAVLEQTTLPTPYPLPQETPLTDSAAALVLGASTGEGPVFVRAHAAGSAAAALGRELGENGEDGTLLVLGPWVTGNVPDHRAVHRVAPGSYCTSLWLELADHWQGWQRDFRRIVLCDTDPRSGRSHVALFAATDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9K2</accession>
    <name>A0A7K2Z9K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_06990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000313">
        <property type="protein sequence ID" value="MYW29027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010058144.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000313.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="22166" checksum="7BA5C2A8726419B4" modified="2021-04-07" version="1">MDFRSSDTITGPRTEDVLPTTATAAVKVVIVGGFGVGKTTMVGSVSEIRPLTTEETMTQAGVGVDDNAGVETKTATTVAMDFGRISLSEELILYLFGTPGQERFWFLWNGLFEGALGAVVLIDTRRLEVSFDVIGRLEERGVPFVVAVNTFPDAPHHPVEALRRALDLPDEVPMIDCDARLRASSRDVLMTLMRYLHSLAVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9P2</accession>
    <name>A0A7K2Z9P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_07105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000318">
        <property type="protein sequence ID" value="MYW29048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="23"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="659"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="713" mass="76958" checksum="9314798F98153DB3" modified="2021-04-07" version="1">MAQQLSPPMVPGEGQSRRTVLVAIGALLLGMLLAALDQTIVSTALPTIVSELGGLDHLSWVVTAYLLAATAATPLWGKLGDQYGRKKLFQTAIVIFLIGSALCGMAQNMPQLIGFRALQGLGGGGLMVLSMAIVGDIVTPRERGKYQGLFGAVFGATSVLGPLLGGFFTQHLSWRWVFYINLPIGVVALLVIAAVLHIPVHREKHTIDYLGTFLIASVATCLILVASLGGTTWAWASAQIIVLAVLAVVLLIAFVAVERRAAEPVLPLKLFRIRTFSLVAVISFVIGFAMFGAMTYLPTFLQVVHGITPTMSGVHMLPMVLGLLLTSTASGQIVSRTGRWKVFPLAGTALTAAGLLLLHRLTPDSSTWEMSLCFFVFGAGLGLVMQVLVLVVQNAVSYQDLGVATSGATFFRSIGASFGVAIFGTVFTNRLTGQLESALAGRSVPPGADAERLAADPRAIQMLPTELRPTILEAYSTSITDVFLYAAPVVLIAFVLAWFLREDKLRGSVTAPDTSQTLASNPVERSSYDECARALSVLATREGRREIYEKITARAGYDLLPAASWLLLRIKRHGTVEPARLAEVTPVPLRVITEAARQVEGRGLARREGLQMILTESGAEAVVRLSQAREDSLAELLGDWWGPERPTDLVKLVAELTAEVSGSSKERPHMPAPPRDHAADRHHDVDHPDHRRYGEHREHREHGDARDHPDHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA09</accession>
    <name>A0A7K2ZA09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000365">
        <property type="protein sequence ID" value="MYW29211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="33776" checksum="E4BAC6C6C3301DE1" modified="2021-04-07" version="1">MNHPPPRTLRTVTGELAADAVRGPVLPHEHLVLDLDRQGDGAAVLDAAHHAAAVTGELSGLRQRFGLSLVVELTCRGMGRDVRALARISREAGVPVVAATGWYYEPFHTPEIDTADVDRLAAVLVREIEDGIGATGIHPGVLGEIGSHGDLPSPAEAKVLRAAGRAALATGLPLATHAQLGRGGLAQLDLLMAEGLPAERICVGHQDLLDDRGVHRELAERGAYVAFDTVGKESYQSDATRLRLLSALVEAGHGDRALLSCDISRHGYLRGEGGQGYGHLFEDFLPALRAAGADDELIDLLTRRNPLRFLTGADVEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA25</accession>
    <name>A0A7K2ZA25_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ORF">GT040_07885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000362">
        <property type="protein sequence ID" value="MYW29200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561462.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000362.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW29200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17863" checksum="0EA5C1341AC851A6" modified="2021-04-07" version="1">MTQTSENVTWLTQEAYNQLKAELEYLSGPARTEIAVKIAAAREEGDLRENGGYHAAKEEQGKMELRVRQLTQLLEHAKVGEAPADDGVVEPGMVVTIAFDGDEDDTTTFLLASREYASGDIETYSPQSPLGIGVNGKRTGDNAEYELPNGKTATVKILAAKPYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA65</accession>
    <name>A0A7K2ZA65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000379">
        <property type="protein sequence ID" value="MYW29271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="108"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="33090" checksum="E6EBB325F8CEA65F" modified="2021-04-07" version="1">MVPGPELLARARLLVAPELNGSLVRELERITGRGAEPLADEVPGGGPLLCVGAALPGPVRAAERLVWFHSVNAGTDPLLAAGPWPAGALLTRTVGRMGERIAQYVVGWVLAECQAVPEYVGQHARAEWRRLPTELVAAQTALVYGTGRIGGAVAGLLRRCGVRTVGVGRTAGSGPPPVGFDRVIGAGEDAEAEELAGARWVVAALPSTGATEGFFGARRFAAVRGATFVNVGRGATVDLGALEGALRDGGVRRAVLDVLAEEPAAPDDPVWRLPRTVITSHSAGITADEDVAQDFAACWEAVREGRRPELAVDVGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA66</accession>
    <name>A0A7K2ZA66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_08065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000369">
        <property type="protein sequence ID" value="MYW29236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="18272" checksum="B336510824C26B46" modified="2021-04-07" version="1">GNGYYGGLQFSQSSWAAAGGTQYASRADLASKDQQIATAEKLLDMQGPGAWACAGAGGLTNDGVDPGVNTGSGRSAGKSEQAQPERKAEQPTTRSEQRTAPAAPKAESSKKTVTTPTGEKVQKGDGEYKVKTGDTLSKIADKEGVKGGWSKLFKLNDDIVKDADLIFPGQQLHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAJ2</accession>
    <name>A0A7K2ZAJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_08880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000408">
        <property type="protein sequence ID" value="MYW29391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="391"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW29391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="607" mass="65643" checksum="9C713AC3C6666169" modified="2021-04-07" version="1">MTLTVAYAATDIPENLNSYATQQDTVYFWADGTPMARAGWVQRQEMELGDVPEDVRWAVLAAENESFYSDPGISAKGLTRAILRTFGQGSTQGGSTITQQYVKNVYLSQEQTYSRKFTEAMMALKLDNKMSKDEILEGYLNTSWFGRGTYGIQRAAQAYYGKDVSELNASEGAFLATLLKGAGLYDPTLGAANRTRAQERWRWTLDRMVKIGKLSPEERAGYRTFPKTLESNPLYNTGEQSDYLVELATQHAKKAADISDKDFDRGGYQIYTTFDKKRVDQLTKAVGAARDKARKDNPKAAKHIHYGAASVAVDGRILAIHGGPDHRKQGYNESNATTVPAGSAFQPFVYAAALEHGVRKSRDGAPEPVTGETVYAGDDKVPVTTPEGPYWDRSGRKVAAKNDGGRSYGQISLHRALASSVNTTFMQLGLDTGLDKVRATAQAAGLLRSSLGAQVPALAAGSSTPSAIRMASGYTTFAAEGRHTEPYTILKVTRNGHKVATDTPDPRRAMDADTAAEVQSALTDAFRTAYPETAAKAGGEVAGKRGTTEGDTAAWYVGTEKKVSTAVVVYRIDLTKSLEPLPLEGLGGTIADSVPYGIWSEALRPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB03</accession>
    <name>A0A7K2ZB03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000451">
        <property type="protein sequence ID" value="MYW29547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029745513" evidence="1">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="339" mass="35573" checksum="A248D117835E4EAB" modified="2021-04-07" version="1">MHARRLLIGAVPLVLVATACGGNDASTTTSDSGKKLDRVTLTLNWYPYGEHAPFYYGKQQKIFEKHGIDLDVRAGQGSQKTVQATAAGQSDFGWADTPALLAGVDQGVKVKSLGVFLQTTPASVQSFDAKGIAAPGDLKGRTIAGTAGDALSKTFPIFLKKNGIAESDVKVQNTDPAGKIAAVISGKTDGLLGYASDQGPTMQDKAKKPVSYLRFSEHGLNFYSNGLLAGQKILTAKPELAERMVKAVSEAWAAAAKEPGPAVEAMEGASEQLPPKSVLSEQLATTLTLLHTEATEGKAPGVNTEADWQQTIDVFAEAGLVASPKAVADYWDTKTALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB86</accession>
    <name>A0A7K2ZB86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_09970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000458">
        <property type="protein sequence ID" value="MYW29593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="451" mass="50375" checksum="C8289BC082BE1233" modified="2021-04-07" version="1">MRRDFDVIIVGAGLTGVTAARELRKKGKRVLLLEARDRIGGRTWTDTWRGSQIERGGTWVDQLQPHIWRELVRYRIPIVADSGVERAILPTLTGFQEYDPVEAYTRQNELFTPFFDGSRDHFPRPYEPFARENLVKPLDRLSLRDRLDQLGYAPEDEIRLTSTTSLYGGSSTRGAFTHLSQWWALSGWNFDGFHGVNTYRPKDGTIALLRAILKDAAPTLRLNSPVKSVVQNSGRVQVTTRSGEQFSAPEVIMAVPVNVWRTIQFSPPLPKAHKAASTAGIGVPHEKKLWLDLKRPADTFVAEAPEGYPICIMGRLNEGDHAVAFSVKDTFDVNQRRQVQNAVRQIIPEAQLLDYTATDWHADEFALGVGAFRQPFQLTRLHRQIQQPHGKVKFAGADIADGWSGYMDGAIESGLRIAGSPTLTGPLPAAVRNSLGAPPVDRRAYRPLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBD9</accession>
    <name>A0A7K2ZBD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CsbD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_10255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000468">
        <property type="protein sequence ID" value="MYW29649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018516358.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000468.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="6004" checksum="4F5472FB2A28AEE0" modified="2021-04-07" version="1">MDKLKGKGKEAVGKLTGDRRKESEGKADQAKATAKDKVDEAGDRAKGVTDSLRDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBL8</accession>
    <name>A0A7K2ZBL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000493">
        <property type="protein sequence ID" value="MYW29761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="140" mass="15409" checksum="7A22F12B1E954418" modified="2021-04-07" version="1">MRALTIRQPWASAIAHGSKRTENRSWPAPAKHLGTRILIHAAASEDRTPRPSRDVPLELTRDMDIWPDTRSAIVAVATLAGCHFDNRCCTPWGMSDYYHWELADVAALPEPVPAKGALGFWTPPADVVNAVCVQQTGVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC07</accession>
    <name>A0A7K2ZC07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000500">
        <property type="protein sequence ID" value="MYW29805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="26516" checksum="D59FF016BB6D2FA1" modified="2021-04-07" version="1">MAELVYRPVVGAARTLFKALDLKIDTQGSEHIPKTGGAVLVSNHISYLDFIFTGLGALPQKRLVRFMAKESVFRHKVSGPLMRGMKHIPVDRDQGEHAYAHALESLRSGEIIGVFPEATISQSFTLKSFKSGAARLAQEAGVPLIPMALWGTQRIWTKGRPRNFKRSHIPITIRVGEPVEAPADQYAGAITRRLRERVQELLEAAQRAYPVRPKDASDTWWVPAHLGGTAPTPAQVRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC22</accession>
    <name>A0A7K2ZC22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000529">
        <property type="protein sequence ID" value="MYW29897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="28063" checksum="2B75878B8AF44678" modified="2021-04-07" version="1" fragment="single">ETLPQDPGPVPGMGPADRRAARGAPVAGIGADLSGGSASATLALLAAGLPGLPGTLLGHGTGAGERLLAVTFNDLTTRGHEDELERARAIAANPRLHHVVVAAGEEALPYASLGTGALTDEPGPSLVVAERHRRRLAAGSADHLVGHGARQVLDAHPARLADLLMDRRRRHLLRPVAALTKAEGPSAHSLFVPLTVYRAARRLARTSYRTGLETAAGLLPDANRYAPDLATPADASLAALAWSRPGPAARWLTGEALAEVSVRLQEAAIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC42</accession>
    <name>A0A7K2ZC42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000537">
        <property type="protein sequence ID" value="MYW29909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="16486" checksum="A3C91261E5E60D36" modified="2021-04-07" version="1" fragment="single">LGSAMTADGRQLLFGLRFAALGGHGSDNEREIVVLEQGSPDGPFRAWRGLGNPATGPDHGRRIGVPVAVTAPDGRVHLFVRNAEKGLSTRVRDADSGRWSGWRDLGGGEVQDGLTAVVDAAGCVHVYAAGHHAVHHWTQDEPGADVTARTQLTGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC43</accession>
    <name>A0A7K2ZC43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_11685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000545">
        <property type="protein sequence ID" value="MYW29926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="54"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="526" mass="54745" checksum="6AB3A776165E5914" modified="2021-04-07" version="1">MSTGSSFPGKTRQTGTTRLTGDTGGINTYKGEERALRANRLGTPGLLLSVLAASAPLMVVAGVMPTVFGVMGIVGQPLLYVILGAVLMLFSVGYAEMSRHVHNAGAFYAYIARGLGPTAGAGASLVALVAYSAMQVGIYGILGFEVSVILSTYAGIDVQWWIPALISVVVVGILGWLKIDLNAKVLGVLLVIECLLVVIFDIAAVSEPGPEGLSFAAFNPETLTGAGLSTALCFCIAAFVGFEQAPVYAEETSRPQIVVSRVMFLAVGYAALFLAISSWALTVAAGPGFIADTSLKEGPGMLFGLTEERLGSTFTDVLHILFVTGMFAALLSFHNVVARYAFAMGREGLLPARFGRTNRASGAPGIGSLLQSVISVVIVLAFAFSDDNHIGDPTVPVLRLFTWMGNVGALGVILLMAAASFAVIAFFVKRGAGRAQAPRLVASGLAGIALLSIAVFTVRDFDVLVGSGDGSALNWLLPGVIVLALIGGLVYGAVLRKAKPEVHARIGLGNEAFQLEKAAESDSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCB8</accession>
    <name>A0A7K2ZCB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">GT040_12075</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000554">
        <property type="protein sequence ID" value="MYW29997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="31"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="373"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW29997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="561" mass="61000" checksum="4EB1828FE302AD18" modified="2021-04-07" version="1">MSHPHPELGTPPKLPKGALRVTPLGGLGEIGRNMTVFEYGGRLLIVDCGVLFPEEEQPGIDLILPDFTTIRDRLDDIEGIVLTHGHEDHIGGVPYLLRLKPDIPLIGSKLTLALIEAKLQEHRIRPYTLEVTEGQRERIGVFDCEFIAVNHSIPDALAVAIRTPAGMAVATGDFKMDQLPLDGRLTDLHAFARLSEEGIDLLLSDSTNAEVPGFVPPERDISNVLRTVFANAQKRIIVASFASHVHRIQQILDAAHEYGRRVAFVGRSMVRNMGIARDLGYLKVPAGLVVDVKTLDDLPDDEVVLVCTGSQGEPMAALSRMANRDHQIRIVPGDTVILASSLIPGNENAVYRVINGLTRWGANVVHKGNAKVHVSGHASAGELLYFYNICKPKNLMPVHGEWRHLRANAELGALTGVPKDHIVIAEDGVVVDLIDGKAKIVGKVQAGYVYVDGLSVGDVTETSLKDRRILGDEGIISVFIVVDSSSGKIVGGPHIQARGSGIDDSAFVGVTPKIQEALDKSAQDGVMEPHQLQQMVRRVVGKWVSDTYRRRPMILPVVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCR1</accession>
    <name>A0A7K2ZCR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000598">
        <property type="protein sequence ID" value="MYW30123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="17449" checksum="1B335FDF42AE4264" modified="2021-04-07" version="1">MVEITPRLSIGQAAERTGLSVHALRFYENEDLFLTPVRRGAGGRRVYSENDVAWLTVCIILRASDMPVPVLRRYAALVRAGAGNEEERLALMREHEARVTGRIGRLTESLDLIRFKAAVYEDIVDQGSAADHDCHGPPAAAEGEERSPVRRREVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDA6</accession>
    <name>A0A7K2ZDA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_13620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000651">
        <property type="protein sequence ID" value="MYW30299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003967428.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000651.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12648" checksum="D658CEED79776AAF" modified="2021-04-07" version="1">MDLSLSTRNVSGPGGDRTVVEVGGEIDVYTAPKLREQLVELVNDGSYHLVVDMEGVDFLDSTGLGVLVGGLKRVRAHEGSLRLVCNQERILKIFRITGLTKVFPIHTTVDEAVAATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDI1</accession>
    <name>A0A7K2ZDI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_7" evidence="1">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12732" checksum="6341B492F6C57D06" modified="2021-04-07" version="1">MSNETPSSISTKNPLKTVINVEDVEAHEVVPGILRRRLPATDYARGWLIDFAAGTEWPEVDEHHTEERYFVISGEVIDGGERHGPGSYVVFAPGSEHRPRTETGARMLGISMMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDP2</accession>
    <name>A0A7K2ZDP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_14575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000681">
        <property type="protein sequence ID" value="MYW30474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="252" mass="25915" checksum="632E65E7DCF8200A" modified="2021-04-07" version="1">MPAPLAPRARLLPSLAAVYRAQLSRARVARIPLLFVATFQSVGIMVLMRGVVDGGAEARAVVAGSSVLVVAFVALNLLAQYFGQLRAGGGLDHYATLPVPPAAVVLGAAAAYASFTVPGTVFTAITGSVLFQLPMTHLWVLVAVIPLSGAALAGLGAALGLLAPRQELATLLGQLGMSAALLLGVLPADRLPEPVGWARDLLPSTYGVEALARSFDASPDWGMIGLFLAVCAVVGVLSLAVATWAYRRAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDU7</accession>
    <name>A0A7K2ZDU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000673">
        <property type="protein sequence ID" value="MYW30455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="455" mass="47766" checksum="34EF1B85AE98E111" modified="2021-04-07" version="1">MSDLLERLRTGLPAEALITDPDVTASYAHDMASFCEAGTPAVVVLPRTVEQVQHVMRTATELRVPVVPQGARTGLSGAANASDGCIVLSLVRMDRILEISPVDRIAVVEPGVINAVLSRAVNEHGLYYPPDPSSWETCTIGGNIGTASGGLCCVKYGVTAEYVLGLDVVLADGRLLTTGRRTAKGVAGYDLTRLFVGSEGSLGIVVKAVLALKPQPPQQLVLAAEFPSAAAACDAVCRIMERGHTPSLLELMDRTTVRAVNQLASMGLPETTEALLLCAFDTPDPAPDLAAVGALCTAAGATEVVPADNPAESELLLQARRMSLTALEAVKSATMIDDVCVPRSRLGEMLAGTAAIAERYDLTIGVCSHAGDGNTHPVVCFDHTDPDESRRARESFDAIMALGLELGGTITGEHGVGVLKKEWLARELGETGIELQRGIKAAFDPLGLLNPGKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEA1</accession>
    <name>A0A7K2ZEA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="237" mass="25597" checksum="1DDECC25E3C3273F" modified="2021-04-07" version="1">MSWHQGPLVGFDLETTGTDVESDRIVTAALVRLDPDGTVVEQRTWLLDPGVAIPEQASAIHGIGTDHARKHGARAASAVAEIAQAVAEVLRSGVPLVVMNARYDLSLLDRECGRYGLDSVERRIGGVPSPVIDPLVIDKHVDKYRKGKRALQALCEHYGVTLSDAHDAAADAVAAVRVVRRMGKRHRPVSSLPPAELHALQVRAAAEQSASLQAYLRRTANPTAVVEQAWPVIPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEJ0</accession>
    <name>A0A7K2ZEJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tox-REase-5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000745">
        <property type="protein sequence ID" value="MYW30728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028904">
        <property type="entry name" value="Tox-REase-5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15648">
        <property type="entry name" value="Tox-REase-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tox-REase-5" evidence="2">
        <location>
            <begin position="88"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="24139" checksum="5D1903D7AB3BF254" modified="2021-04-07" version="1">AAEARAAERAAHLEQKRLEEPERARKAELEKKQHPEPQRNDTSDPRNYNPPSWAEDLKSRTLGDADAGDGYWASRDRNPAPNWKNESWLRYQEQITGTNRGQEYVVPHPREGKPAVEYDGWDSSRQTYLEAKNGYGSYLSKTDPGTLTPSGKEKFVAEARAQVEASGGKPVEWHFSDPEVAKAARKAFRDEGLPIKVVPTPVKPGDSTRKPGAFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEQ1</accession>
    <name>A0A7K2ZEQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine betaine/L-proline transporter ProP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proP</name>
        <name evidence="7" type="ORF">GT040_16515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000767">
        <property type="protein sequence ID" value="MYW30833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="499" mass="54096" checksum="2C172E4A59F5E972" modified="2021-04-07" version="1">MVRTVIRRRKRSLREQDVTVTDPPKVRRAVTAAALGNTMEWFDFGVYAYLAGTLGKVFFPSSSPGAQVVSTFATFAAAFLVRPLGGLVFGPLGDRVGRQKVLALTMIMMAASTFAVGFLPTYAAIGFAAPLLLLVCRLVQGFSTGGEYAGATTYIAEYAPDKRRGFLGSWLDFGTFVGYSLGSGLVTVLTAVLGTDGMTDWGWRIPFFVAGPMGLIGLYMRLKLEETPAFQREEEAQARARTENDPVEEARQSGKGRLKEIFTRHWQAVLICMGLVLLYNVTNYMITSYLPTYMSQTLGEPETKSQLLVLGTMLLVVLTITTVGRTSDRWGRRPVFMAGSVALIVLAAPAFLLIRQGGILLPSLGCAVLGLLLVCFAGTAASTLPALFPTRLRYGALSIAFNISVSLFGGTTPLFASALVEATGDEMVPAYYLMVAGVIGLVATFFLHETAGRPLRGSGPMVETPEQARQLVARSRTTAGRQARDVWLRVRHLWRGPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEU3</accession>
    <name>A0A7K2ZEU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000778">
        <property type="protein sequence ID" value="MYW30887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="172" mass="18591" checksum="13BB1F567188C9AB" modified="2021-04-07" version="1" fragment="single">MVDAHRTFVIVGAGLAGAKAAETLRAEGFTGRVILIGDERDHPYERPPLSKGYLGGKEERDSVFVHERPWYAGADVELHLGQPVTVLDRYAKTVQLGDNTVIHYDKLLLATGSEPRRLDVPGTDLVGVHHLRRLAHADRLRNVLAALGRDNGHLVIAGGGWIGLEVAAAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF81</accession>
    <name>A0A7K2ZF81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YggT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000815">
        <property type="protein sequence ID" value="MYW31017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006123846.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="66957010"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="10692" checksum="D466F9255DCBBB95" modified="2021-04-07" version="1">MGVALDVVYIALMCFLIVLIFRLVMDYVFQFARSWQPGKAMVVVLEATYTVTDPPLKLLRRFIPPLRLGGVALDLSFFVLMIIVYILISVVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFP4</accession>
    <name>A0A7K2ZFP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000863">
        <property type="protein sequence ID" value="MYW31197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="368" mass="37938" checksum="C90432034D1FB40C" modified="2021-04-07" version="1">MRVLVTGGAGFIGSHVVAALAAAGHESVVLDALLPSAHPGATAPEIPGARLVVGDVRDREAVAGALAGVDAVCHQAAMVGLGKDFADAPLYVGCNDLGTAVLLAEMAAAGVRDLVLAGSMVVYGEGRYDCPSHGTVRPGPRPEAGLRAGSFEPHCPDCGTELVPGLVSEEAPADPRNVYAATKLAQEHLAAAWARATGGRAVSLRYHNVYGPGMPRDTPYAGVASFFRSALARGEAPRVYEDGRQRRDFVHVHDVAAANAVALEAVRERRAASFAAYNCGSGDPHTIGEMATALAAAHGGPEPVVTGEYRLGDVRHVTADSRRLREELGWRPEVGFAAGMAEFARAGLRGAEASRIAAAPQPVGAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG23</accession>
    <name>A0A7K2ZG23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000884">
        <property type="protein sequence ID" value="MYW31307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="380" mass="41027" checksum="CCD2242EDE3D9238" modified="2021-04-07" version="1">MDKTLIVTNDFPPRPGGIQAFLHNMALRLDPDRVVVYASTWKRGEEGTTATAAFDAEQPFTVVRDRTTMLLPTPRVTRRATDLLREHGCTSVWFGAAAPLGLMAPALRRAGARRLVATTHGHEAGWAQLPASRQLLRRIGESTDTITYLGEYTRSRIAAALTPDAAARMVQLPPGVDEKTFHPASGGDQVRARLGLSDRPVVVCVSRLVPRKGQDTLILAMPAILAQIPDAVLLIVGGGPYAKDLQRLAAETGVADSVRFTGPVPWAELPAHYGAGDVFAMPCRTRRRGLDVEGLGIVYLEASATGLPVVAGDSGGAPDAVLDGETGWVVRGGSAEESADRIVTLLGDPELRRRMGERGRAWVEEKWRWDLLAEKLKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGA5</accession>
    <name>A0A7K2ZGA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000898">
        <property type="protein sequence ID" value="MYW31335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="18491" checksum="A47D02FD0BE6EA88" modified="2021-04-07" version="1" fragment="single">VADQEVADFARTRLRPRVAVRTPHAARLAAVVSREARAARRSVEVVPEPNGRLTVYGSTCAEVGDTAFRHGVPVHQLADEIGDTGPAAAPPPDDGTRQPSAAALSELPPPIRVRPARGPLRPLRYELRRSLGVRTTTMIMASVLLVSAALSVLLARTGGTPLPRALAAWPELLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGB1</accession>
    <name>A0A7K2ZGB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000911">
        <property type="protein sequence ID" value="MYW31403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="143" mass="14789" checksum="31308BD87DA07254" modified="2021-04-07" version="1" fragment="single">MDFTFTEEQQAAVEAARAVFSGVAPDSVPSPALTPGAVAEDIDRRLWGELAGSDLLGLTLSEEYGGAGLDPVALFLVLRESAKVLARVPLLESCAVAMAVERYGESGLAAELLPRAARGELVLTAGANGRTGHDPAELAVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGJ4</accession>
    <name>A0A7K2ZGJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_19810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000924">
        <property type="protein sequence ID" value="MYW31460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029721644" evidence="7">
        <location>
            <begin position="38"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="8">
        <location>
            <begin position="411"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="529" mass="53618" checksum="023F94DB58C72463" modified="2021-04-07" version="1">MSVMRHTPHARRLAAATVIATAAAVALATAGTLPATAAESAPEGVILNAGAQGTISDSYIVTLKDSAVKSDSAQGKALAKKYGASIERTYRSALNGYAVEATAAEAKKFAADPAVASVSQNRTFTVSATQNNPPSWGLDRIDQRNLPLDQRYTYPDKAGEGVTAYVIDTGVRISHSDFGGRAFNGYDAIDNDNVAQDGHGHGTHVAGTVGGTAYGVAKKAKIVGVRVLNNQGSGTTAQVVAGIDWVTANAVKPAVANMSLGGGADSVLDAAVQRSINSGITYAVAAGNESTNANTKSPARVADAITVGSTTNTDARSSFSNFGAVVDIFAPGSSITSTWNTSDSATNTISGTSMASPHVAGAAALYLADNPGSTPAQVSAGLVAAATTGVVGNPGSGSPNRLLYVGTGSTNPPEPGKKFENTTSYPINDNSTVESPVTVSGITGNAPSALKVPVNISHTYIGDLRIDLVAPNGTVFNLKAFGSGGSADDVVTTYTVNASSVAANGTWKLRVADNYAADTGRINSWGLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGT2</accession>
    <name>A0A7K2ZGT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_20360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000965">
        <property type="protein sequence ID" value="MYW31564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="124"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="517" mass="55700" checksum="3FD5F155EAAAC91F" modified="2021-04-07" version="1">GAWRVHPADPDLTGVAATVHALLEPHFGSRLLPLGTVHRPDVPTLTLALGDGADGSPAPIGVAPDGTARPVDESYRLTVEADGILCRAATPAGVFRAATTALHLLVTSGDRVPRQEMADAPRHAWRGLLLDPARGYLTPDEVRRVIDLAALYKLNVLHLHLTDNEGWRLEIPGTPELTAPAPDGTPRAFYTTDDYRELQAYAAERFVTVVPEIDLPGHCATLREALPGLPDAPVPEWLAGRFPFVAPLDLTDRSTREAVATILTDVCRLTDGPFVHVGGDEAVGATDESFAHSVRELRSLVRKSGKRPLGWQESSRAGVGPEDILQFWVDVPMMDLPDTADEIAARPELVAAGTTLEFVQALKSFFAPTDQDLARILDGGGRVLLSPQSHLYLDRAYAPEIVPAGREGDAARLGFPTYRPLGVEHTAAWDPASHGIPEDRVAGVEATVFAESVESLDDVTTLLLPRLASVAAAAWSGRAPDWAGHRARLAHHGRLWEQRGLAYLPSTEVPWVTAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGX0</accession>
    <name>A0A7K2ZGX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000944">
        <property type="protein sequence ID" value="MYW31529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="12476" checksum="8A9AA991CD92C270" modified="2021-04-07" version="1" fragment="single">MGIVAGLDSSSAFTHIVVCDTDSGAVLREGYAAHPVEAKASEVDPQAWLLSLGEAASGGLLEGVQAIGVSAQQHGLVPLDRQGNLVRPALLGNDRRAQVAAADLVDALGGRQAWAEAVGAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH48</accession>
    <name>A0A7K2ZH48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000984">
        <property type="protein sequence ID" value="MYW31676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="322" mass="34495" checksum="114AB2D3DB63E493" modified="2021-04-07" version="1">MFAAYAARIDPDQPLDGLELGERPAPEKRPGWSTITVRAASLNHHDLWSLRGVGLSQDRLPMILGCDAAGIDEDGNEVVLHSVIGQSGHGVGPKEPRSILTERYQGTFAEQVTVPTWNVLPKPEELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGKAAGLRIFATSRDETRRKRAVELGALAAYEPGARLPQRVDAVIETVGAATWSHSVKSLRPGGTLVISGATSGDRPSHAELTRIFFLELKVVGSTMGTKDELEDLLAFCATTGVRPVIDEVLPLDRAREGFQRLADGEQFGKIVLRPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHK6</accession>
    <name>A0A7K2ZHK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001024">
        <property type="protein sequence ID" value="MYW31843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="623" mass="67528" checksum="CBFC5512E4757F9A" modified="2021-04-07" version="1">MTTAEPKPGREADSSSGEIADGDSAAPRVLLPSPRTPEPSAPEPDAAPEPSATQARRLLRHPVTIATAAAAVTHVLWFLFFANSGGDIAAQDAWAEFVGRHPGTAYNLAWYGGMHPVSYSVVSPYLMSVLGVRSTMMIVGTVSAALTALILVRVRAVRNPLACSLAGVFAYLCNALSGRVTFGLGMMFAVGAVAAVFCWPHRWRYKRWAKAAVAAPLAALATASSPVAGLFLGVVAAALFLHKRRPGAYAIGLAPVAVVALSSLLFPFSGTQPMSLGTVALPFLFAVLVFVLVPRDWSTVRTAAAVYGLGTVLTYFVDSQIGSNVTRMAMLFAGIVLLAALPYTVPRSRRWYALVLAFAGLNFWIGFKGVDDIVRTTPDASWARSLAPLVNQLQQVGAERGRVEVVPASSHREASALATYNLARGWNRQADMKRNPLFYDDTLDAVNYRQWLDRWAVHYVVLPTGRPDGGAERETELVGKGLSYLREIWSDENWKLYRVLEPTPLADPPATVEKAGANELTIRVESAGRVLIRIPHSRWLAVVDEQGKAVERPQETEESKLRTQEDETAPKTFDNLHGCLNKIVDEGPYGDEWTELLAPEPGVYRLAAPYQLQPGTPCPEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHT2</accession>
    <name>A0A7K2ZHT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xth</name>
        <name evidence="3" type="ORF">GT040_21685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001021">
        <property type="protein sequence ID" value="MYW31819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="28240" checksum="544CBC72B7BC3650" modified="2021-04-07" version="1">MRIATYNVNSITARLPRLLAWLESSGTDVLCIQETKCTAEQFPAEALREAGYESAVNATGRWNGVALLSRVGLTDVVSGLPGGPEYEGVQEPRAISATCGPLRLWSVYVPNGREVEHDHYTYKLAWLEALRKAVAADAAGSLPFAVLGDFNVAPTDEDVWDPALFAGATHVTPAERAALAALEGEGLGEVLPRPLKYDRAYTFWDYRELRFPKNKGMRIDLTFGNPAFTAAVTDSYVDREERKGKGASDHAPVVVDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHZ1</accession>
    <name>A0A7K2ZHZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3073 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001062">
        <property type="protein sequence ID" value="MYW31964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_031126291.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001062.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="85" mass="9296" checksum="D3C74F7159E11510" modified="2021-04-07" version="1">MGRGRAKAKQTKVARQLKYSSGGTDLSRLANELGASPSSQPPNAEPFEDDDEEDDPYAQYADRYNEDDGEDQDDQSGPSSQRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI46</accession>
    <name>A0A7K2ZI46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_22790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001067">
        <property type="protein sequence ID" value="MYW32021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="25"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="51882" checksum="594C6E0DC28D7B5C" modified="2021-04-07" version="1">MSFFTDLAHQYIDGEWRPGKGSWDIIDFNPFNGEKLASIPVATAEEVDQAYRAAERAQQAWADTNPYARRTVLEKALRIVEEREPEIAEAIVAELGGTHLKAGFELHLAKEFLREAIQLALRPAGQILPSPTEGKENRVYRVPVGVVGVISPFNFPFLLSLKSVAPALALGNAVVLKPHQNTPICGGTLLAKVFEDAGLPAGLLNVVVTDIAEIGDTLLEHPVPQVISFTGSDKVGRHVATVCAANLKRAVLELGGNSALIVLDDADVDYAVDAAVFSRYVHQGQVCMAANRILVDRAVEAEFTEKFVAKVASLTVGDPADPATQIGPLINSSQAESISRLVDETVESGATALLHGRADGNLVSPSVLTGLPADSPVLQQEIFGPVALLVPFDGEDEAVRIANDTPYGLSGAVHTGNIERGVRIGQRIHTGMIHINDGTVHDEPIVPFGGEKSSGLGRLNGESMVEAFTTQKWISVQHGRSQFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI85</accession>
    <name>A0A7K2ZI85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001076">
        <property type="protein sequence ID" value="MYW32061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="235" mass="24889" checksum="B9B17712DF50CAAE" modified="2021-04-07" version="1" fragment="single">MKPFGYQRPTTTTEAVRLCAEGTGARFLGGGTNLVDLMKLGVEEPGLLIDVTKLPLDRVAPAPDGGLRIGATVRNSDLAAHPDVRRDYPVLTQALLAGASGQLRNTATTGGNLLQRTRCSYFQDVSKPCNKRLPGSGCPAREGSHRDLAILGHSAECVATNPSDMAVALAALDATVVLLGPEGERAVPVTEFHRLPGENPDQDTVIRPGELITEVVLPPPAPGTVSRYRKARDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIG0</accession>
    <name>A0A7K2ZIG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="688" mass="75329" checksum="27C3B3ADBD627A26" modified="2021-04-07" version="1">MAIKLVSVSPAQDELIKRVIALGDRYTRTLGLLKPPAYRKAAEDGGLLAAVEGDEVIGYALFGLPKRSARIRLAHLCVAEEQRGRGVGRKLVEGIRGRYPQRLGIKAKCRRDYNLSGMWRSLGFVPDGEVRGRGRDGEILDGWWLDLGHPDLFTEMESDALLVVTVDHGVFADLRGLTDSADAEESRALEAGWMADLVELAYTPQLVHQIRDLTITSERQHQQAALSGLRKLSPASAAVDTRSRQLLQAATQAIPELTVDPGVRLRLRYVAETSCAGLQVLATRDPLLNRLADVAWEVARVRVVSPSTVTLHVDELRQAQMYRPADLMGTEFRSGEVAPGAEEELVAFFNQTGGDDGSAFAERLRALDQGTVAWRRELLRDGQGHPVALYAWALDGRTLVVPILRTATHPLEETLTRQLLFLLKRLGRDSGAEIVRVSDPHPSEAAKSAAGDDGFFERRGELVALVVDVCGTAAEVGIVAGGVARELSVDTAALQPGIPAELASVVERAWWPAKVIDSELPSFLVPIRPRWSTELFNVPAMLIPRSETLGISREHVYYRSSGRRGESVPARLLWYVSEGSSPSEGQMVVGSSRLDEVLIDKPDALFSKFEHLGVYGQAEVREAADASGSAMALRFSDTEIFPKPVTLRRLTSLARERGIPWSPGSLISLSKISSKLFQAVYQEGHRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIR0</accession>
    <name>A0A7K2ZIR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001114">
        <property type="protein sequence ID" value="MYW32224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029549030" evidence="1">
        <location>
            <begin position="25"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="353" mass="36712" checksum="F1DF55850819453B" modified="2021-04-07" version="1">MRRYARTVVAFALATSVVTGTAGWVSGDAQQALTGPPPGATSWRADRVLGAELPDPERASPAEVAAFFDGLSQRERQLILVRHPSVVGNLDGAPLELRYRANSLSLATAEDPRYRSLAAPGRQILAFDPRGRGQVAEVFGDLRSARRVSVVVPGSDNDAGTFDRKAAAHGAPPGMARTLHQAAGPGTAVIAWAGYTTPVGVGIDAATGRLAEAGAGRLERFTRGLTADGLPEPAVFCHSYGSVVCGLAAHRLPATDLVVLGSPGMRADDVDGLRTRATVWAAKDPTDWIDDVPNVRFAGLGHGTDPTDPAFGARRIPAGDARGHTGYFAPGTDSLRAFAVIARGAATEEGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIV1</accession>
    <name>A0A7K2ZIV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001128">
        <property type="protein sequence ID" value="MYW32280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514727.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001128.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7656" checksum="8D161691F9F70310" modified="2021-04-07" version="1">MKKFIEAVGFIILLQGLGGLVYEWTGWLRLWTLAQHIDYFGDRALFVSIVLIVTGFAIMIAPDAVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIV5</accession>
    <name>A0A7K2ZIV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_23735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="31"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="273"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="841" mass="92204" checksum="2E2BF18B2A7D35A8" modified="2021-04-07" version="1">MSSTDRVDQREAAQREAIDAVVRALELPARSLVPERGLRTQVIMATGSGKTRVAVRSAEELHAGRVLVLVPSLDLLAQTETAWREGGRRGPMIGVSSLRGEEVSFPNTTDVDELVEWTRGLDKVTVYATYASLGLGTLERAHAGGLAAWDLIVVDEAHRVSGRIGKPWAVVHDNQKIPSLRRLYMTATPRLWQLGDEDEAGAPGELVASMEDDPEGPFGSRCFTLTLSEAIDRGICAPYQVVCVDVTDTQLQAAQLLGAESRSAEVRGARLAALQTALVKASAEENFRRTLVFHHVVKEAEAFAAGLPDVAAQLHASDPELYPKTIWADWLCGDHKPLHRRRLLGEFAAGIATDGTVVEKCFLCSVKVLGEGVDTKNCDSVYWADVRGSMPDLVQAVGRALRMQPGEGKVASLVVPVLLGPGETADNMLTSRAFGGLAKLLEALRAHDARIVESLAEQQAPSRYKPVSKDDSGKSTDGSGEGSGGVSGPAKALLKFSTPRDPAALAAFINLRVLNPEHEHWRRGVEAAVIYAREHGDLRVPFTFRVPAAVDGQEAEEAGWPASLAGFPLGQWTADARRFYARGDMDEDRVAQLEKLGMIWSHFDVAWEEGLSAARGWAAEHGHLLAPLDATFQGAKVGIFLKNARAAARKAQENEQRRAEGLPVESSAGALSDERREQLEEIDASWCPSWPVTWQRCFHLVRMHLDAGEALPTEAGDVVRQGEDLGRWVQSVRLGWDELTAVQQWMCEQVLGIEPASEDEKPKRRTQADKWAMNYEAARQFYEREGHLQVPRKHVERIVGGEDQEEREHKLGAWIGNQRSRASTLTPERMELLSAIGMRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ10</accession>
    <name>A0A7K2ZJ10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltX</name>
        <name evidence="13" type="ORF">GT040_24515</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01001151">
        <property type="protein sequence ID" value="MYW32343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="6"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="347"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW32343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="491" mass="54428" checksum="476DAC1BC435D6A8" modified="2021-04-07" version="1">MANAPVRVRFCPSPTGNPHVGLVRTALFNWAFARHHQGTLVFRIEDTDAARDSEESYQQLLDSMRWLGLDWDEGPEIGGPHAPYRQSQRMDLYKDVAEKLLAAGYAYACYCTTEELDTRRDAARAAGKPSGYDGHCRDLTEEQKAAYEAEGRTSIVRFRMPDEAITFTDLVRGDITVQPENVPDYGIVRANGAPLYTLVNPVDDALMEITHVLRGEDLLSSTPRQIALYRALIELGIAKDTPAFGHLPYVMGEGNKKLSKRDPQASLNLYRERGFLPEGLLNYLSLLGWSIAEDRDIFSVDELIAAFDIEDVNANPARFDLKKAEHINAEHIRMLDVKDFTEACGPWLKAPFAPWAPEAFDAEKWTRIAPYAQTRVTVLSDITDNVDFLFLDEPVEDEASWTKAMKGDPAALLTTARANLEAADWSDPESLKNAVLTAGEAHGLKLGKAQAPVRVAVTGRTIGLPLFESLEILGREKSLARIDAALAKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ19</accession>
    <name>A0A7K2ZJ19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AURKAIP1/COX24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001152">
        <property type="protein sequence ID" value="MYW32350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948845.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001152.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="COX24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1713" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="32" mass="4045" checksum="3DE18FA26371F5A9" modified="2021-04-07" version="1">MGSVIKKRRKRMAKKKHRKLLKRTRVQRRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ21</accession>
    <name>A0A7K2ZJ21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_24420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001148">
        <property type="protein sequence ID" value="MYW32327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="46"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="410"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="508" mass="54094" checksum="70CB07A87942F110" modified="2021-04-07" version="1">WTDCATDGYECARLTVPRDYARPGNGRTFVLPVARAAATGPARRIGSLVYNPGGPGAGGASSLEEGMDESFGAAVRARFDIVSFDPRGVGGSVPALTCEPDEAEAEAEAEEPEAGVEEEPAEETSEEVSDAVAPLYPRTEADRSAAASGARTAADDCEEHSGPILRHVGTEDAARDLDVLRAALGERELTYLGWSYGTSLGTAYAEQFPRRVRAMVLDGAIDPSLDWRQRVISQSAGFRRSVDDYAEQCAEIAGDSCPGASPQEIRALIERLYQRAEREPLPVAEDSTYAEYGGMDASAVLDAVSMAMYTPEDQWEPLSEALREADQGDATKLGALDDEEETEEGTEDPGTAEEEQEEQGEQEEDETPEPPADNGDAALTAVNCLDVPHPRSLRPYWDALAPADQAAGVYGTAGVTAELTCRDWPSGGRRPHRVVADGVPPVLVVGTTGDPATPYEESVSLAEQFPEGMLLTYEGLGHTAYGRGGACVTAKVDAYLVKRERLRPGATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJA9</accession>
    <name>A0A7K2ZJA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001164">
        <property type="protein sequence ID" value="MYW32427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="4"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="22052" checksum="71560DD75D4DF4C8" modified="2021-04-07" version="1">GVLKAALDRGGALFGLLALAPLLLAVALCVRLSSRGPVFHRQVRQGQHNRPFTMWKFRTMVADAEARKAQLSEDNEVDGPLFKMRRDPRVTPVGRTLRRMSIDELPQLFNVLLGQMSLVGPRPPLPEEASRYDEREGRRLAVKPGLTGLWQVSGRSDLSWQETVSLDLWYVDNWSVAMDMGLLARTVRAVTDGRGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK09</accession>
    <name>A0A7K2ZK09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001221">
        <property type="protein sequence ID" value="MYW32678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="12526" checksum="7C3D0742A4A742DB" modified="2021-04-07" version="1">MCPSRGVLEHVTSRWGVLVLAALLERSYRFSELRRTIGGVSEKMLAQTLQTLERDGFVHRDAKPVIPPRVDYSLTALGTEAAEQVWALARWTERQVDTVQAAREAYDEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK25</accession>
    <name>A0A7K2ZK25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Segregation/condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_26335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001226">
        <property type="protein sequence ID" value="MYW32694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="181"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="295" mass="32743" checksum="34B093BF33AD12A9" modified="2021-04-07" version="1">MPETAQEPVQTGAEPAEPPEAADDKRFTVRLVNFEGPFDLLLQLISRHKLDVTEVALSKVTDEFMAYIRAMGPDWDLDQTTEFLVVAATLLDLKAARLLPAAEVEDEADLALLEARDLLFARLLQYRAYKQIADIFSGRLESEARRHPRTVGLEDHHAELLPEVVISIGPEGFAKLAVKAMQPKPRPQVYVDHIHAPLVSVREQAGIVVERLREAGAAVSFRTLTEDAPDTLTVVARFLALLELYREKAVTLDQDEALGELLVAWCGGEGAEPVVTDEFDQELNGTAEQEEDVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKI9</accession>
    <name>A0A7K2ZKI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein GT040_27235</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaaA</name>
        <name evidence="2" type="ORF">GT040_27235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001266">
        <property type="protein sequence ID" value="MYW32867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="28159" checksum="800E1243B12B8C34" modified="2021-04-07" version="1">MLVLLPPSEGKAASGRGAPLKPESLSLPGLFEARAAVLEELVELCQADEEKAREVLGLSVGLRGEVGKNAELRTAGTRPAGELYTGVLYDALDLATLDADARRRAAKSLLVFSGLWGAVRIGDRIPPYRCSMGVKLPGLGALGAYWRTPMESVMPEAAGGGLVLDLRSSAYAAAWKPKGEVAARTASVRVLQSQIVDGVEKRSVVSHFNKATKGRMVRDLLSAGARPEGPAELVDALRDLGYVVEAEAPARAGRPWSLDVVVTEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKM6</accession>
    <name>A0A7K2ZKM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AfsR/SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001281">
        <property type="protein sequence ID" value="MYW32907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="26182" checksum="E046D6856CB529F5" modified="2021-04-07" version="1" fragment="single">ALALTSASEAIPDPVGRGRALWLCAYGLFSAGDVTGSGELNTRALTLFTTAEDRWGTAAALGLRATLALVGGDLTGLGRDGTRSAQIFRELGDRWGELQTVSPLAALAEIKGAYEDAERRQHEGLRMARELGLEAEVSARLSGLGRLALLARDFGRARDLHEQARRIAAEQGYKYGEIHSEMGLALGARRSGDLDGAEAHLLHIRDGYADVSSPAGDHLLLAELGFVAELRGDAHAAAAHHLAGLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKR3</accession>
    <name>A0A7K2ZKR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001261">
        <property type="protein sequence ID" value="MYW32839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="85" mass="9266" checksum="6F7D5944CAE21406" modified="2021-04-07" version="1">GLISHLARPEADTAELARVVRPGGVLALFHPIGRAALAARHGRTVTDDDVRAEPRLRALLAGSGWRLDSYTDEDDRFLALAVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL02</accession>
    <name>A0A7K2ZL02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001305">
        <property type="protein sequence ID" value="MYW33025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029751775" evidence="1">
        <location>
            <begin position="28"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="284" mass="30635" checksum="45E5743AD14B02AF" modified="2021-04-07" version="1">MPPRRRSRLLLTAALLGALLGAPPAAAAAVSPAVFPGVPLRVATYNIHAGAGMDNVFDVDRQTSELRSLNADVIGLQEADRHWGPRSEWRDLAGELAERLGMYVYFAPIYSLDPAEPGGPRAEFGVAVLSRYRIVSADNHEITRLSTQDPNPSPAPAPGFGEAVVRVKGRPVHVYVTHLDYRPDPAVRVAQVADTRRIMAEDRGPKILLGDFNAEPGAPELAPLWGELTDADPGAPTFPAQDPVKRIDYVAVSKGAAQVRRAWVPESMASDHRAVVADLVLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL53</accession>
    <name>A0A7K2ZL53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001299">
        <property type="protein sequence ID" value="MYW32979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029515505" evidence="2">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="244" mass="26288" checksum="1D15FCA38418BBDD" modified="2021-04-07" version="1">MKRNVTIAAVTAAVLIGGTAAATVAFADDGDDRRTGTSSVHPSVGTERSDDNREDRDDRDDRRPETGKAAGITLDQAVAAALKSAPGTVTEAELDHDDDDNDGRTVWELDVYGSDRTWHDVTVDATDGKVLKTRDDDNDDRDRNAPRSSTVTLKQAADAALKTAPGSITSIDLDDDDDDDDKGSRGNVLSWDVDIAGKDGRSHELRVDAKTGKVTVDRDDDGDDRDDSADDRDDRNDDRDGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL94</accession>
    <name>A0A7K2ZL94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_28550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001324">
        <property type="protein sequence ID" value="MYW33115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="130"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="263" mass="28370" checksum="C7D7D73A4E60B4E8" modified="2021-04-07" version="1">VRPRHLVPDIPRNAEPRTGLSMGEHAARTARRWAVTREDQDRLAATSHQRLAAAYERGFLDDLVVPYRGLTRDQNLRPTSTPEQLAELKPVFGTSMDNPTMTAGNSTPLTDGAATVLLASEEWARQRGFEPLAYLTLHETAAVDYVDGDDGLLMAPAYAVPRLLERAGLGIEDFDLYEIHEAFASQVLATLAAWEKRGLSPLDRTRLNVAGSSLATGHPFAATGARIVATLAKLLAEREAPGRGLISVCAAGGQGVTAILERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLW3</accession>
    <name>A0A7K2ZLW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_29840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043760">
        <property type="entry name" value="DUF5706"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18967">
        <property type="entry name" value="DUF5706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="180" mass="19096" checksum="EE1F99BF8AF704E3" modified="2021-04-07" version="1">MNSPPPAPPPHPPRPGPAPGLETATRLLADLRAEIARADSKAAVVVAALGMSGGVLSGVLVGRDWSPDHLSRTGTFLWWVGTAVLTIALLFLLMAVLPRYRVSTWAPGSPLTYFGDIQRAVRQGRLPEALAVTERLPMASLLTALTETSRIATRKHQWIRAGLVAFCLGALLLPASVVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM62</accession>
    <name>A0A7K2ZM62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">katG</name>
        <name evidence="12" type="ORF">GT040_30305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="WWKE01001395">
        <property type="protein sequence ID" value="MYW33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="155"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-121)" evidence="8">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="751" mass="81736" checksum="F65DDAC2563F8F3E" modified="2021-04-07" version="1">MTENNESHVFDPVVPDSPETAIPEVPEAQASGCPVAHGRAPHPTQGGGNRQWWPDRLNLKILAKNPAVANPLGEDFDYAAAFQSLDLPAVKRDIAEVLTTSQDWWPADFGNYGPLMVRMAWHSAGTYRISDGRGGAGAGQQRFAPLNSWPDNGNLDKARRLLWPVKKKYGQALSWADLLILTGNVALETMGFKTFGFAGGREDVWESEEDVYWGPETTWLDDERYTGDRELENPLGAVQMGLIYVNPEGPNGNPDPVAAARDIRETFRRMAMNDEETVALIAGGHTFGKTHGAGPAESVGADPEGAPLEEQGLGWRSSYKSGKGGDAITSGLEVTWTSTPTQWGNEFFHNLFAYEYELTKSPAGAHQWVAKDAEATIPDAHDASRKQKPQMLTTDLSLRFDPAYEQISRRFHENPEEFADAFARAWYKLTHRDMGPIQRYLGAEVPSEVLLWQDPLPARTGELLDAAEVAALKEQVLATDLTVAQLVSAAWASAASFRGSDKRGGANGARVRLEPQRGWEANDPDELAQVLRALEGIQESFNAEGGKQVSLADLIILAGNAAVEQAAKDAGVEVEVPFTGGRVDATQDQTDVESFAALEPAYDGFRNYVGKATRLPAEYLLLDRANLLTLSAPEATVLVGGLRVLGANSGGSKHGVLTDRPGTLTNDFFVNLLDLGTTWKSTSSAQDEFEARDASGKVKWTGTRADLVFGSNSELRALAEVYASDDARQKFVTDFVAAWTKVTNLDRFDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMC5</accession>
    <name>A0A7K2ZMC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001397">
        <property type="protein sequence ID" value="MYW33458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="537" mass="57462" checksum="66212377BFBC1CD5" modified="2021-04-07" version="1">MNPVVEKLELAEPHLANWLSTLGLDVEYVRSGGNTLFYRRADGAEIPVLDLVGGYGSVVLGHNNPEIVAYAKSLLDGGTPVHAQFSRHPYANDLAWKINGIIHREFGDPEPYSAIFANSGAEANEVAVKHAELDRVLKLAELLEGVAAHAEEARAAVGTGARLEVSAEALAALGVEGDPAQEGGEGIERVLAAVDRVNAERAGTAPVFLAPEGSFHGKLIGSVQFTHNPGYRTPFTALAARCRFVDVSRPEALTEAIDEERRSLFDLQAEDGTIRVVERELPVIGAFLLEPIQGEAGIRVFDREAARRIQDACATAGIPIVVDEVQSGMGRSGAFFAASHIGLRGDYITLAKSLGGGIAKAGLTLVRGSRYRTDFELVHSSTYAKDSFSTLVAAKTVELLEADEGKAYRLAETRGNQLLEVLEGLRKEFGDIVADVRGRGLMLGLEFHDQSGSTSEIIREQAGAGLLGYLFSGYLLRVHSLRIFPTASATNTLRFEPSVYLTDEEIARTEAGLRGLIAVLREQDGETLLHGGAASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMJ6</accession>
    <name>A0A7K2ZMJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_30885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001433">
        <property type="protein sequence ID" value="MYW33552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="623" mass="66007" checksum="7E3CD079F2588AD7" modified="2021-04-07" version="1" fragment="single">MTGTETPTHCPYCALQCGMRLRPVAGPEVAEVVERTGFPVNRGALCGKGRSAPAVLRRGVRLTSPLVRRRPGGELEEAGWDEALGRIAEGLGGVRAAHGADAVGVFGGGGLTNEKAYALGKFARVVLGTSQIDYNGRFCMSSAAAAHQRAFGLDRGLPFPLEDIPRTGCVILVGSNLAETMPPALRYLTELKANGGRLIVVDPRRTRTAEQADLHLAPRPGTDLALALGMLHLVVAGGRVDEEFVRSRTRGWEEARAGAMAHWPELVERICGVPVARLREAVELFCGAESGMVLTARGPEQQAKGTDTVGAWINFCLATGRAGRPLSGYGCLTGQGNGQGGREHGQKADQLPGYRKLTDPAARRHVAGVWGVAPGSLPGPGRSAYELLDALGQDVRALLVMGSNPVVSAPNASHVERRLASLDFLAVADVVLSETAALADVVLPVTQWAEESGTTTSLEGRVLLRRRALDPPEGVRSDLEVLHALAGLLGHGKGFPADPAEVFEELRRASAGGAADYAGITYERIAAEDGVFWPCPDADHPGTPRLFLDRFATEDGRASFVPVVHRAAAEETDREYPVVLTTGRVVAQYQSGAQTRRVDELNAAAPGPFVELHPRLAERIGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMP7</accession>
    <name>A0A7K2ZMP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="127" mass="13578" checksum="8EB82BB55D0ED6B3" modified="2021-04-07" version="1">MVTPMQAASDIADAVRNLNHATLNHGEGWEHPGDAYSVIGSLASGAHGLTEALEQVSRVLYDLHTEGQLVSVDGAEETDNQVISARGYLRKAREHTDTLSTLLRDAHTAMSGLAVLGPHTTTQEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN12</accession>
    <name>A0A7K2ZN12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ectoine/hydroxyectoine ABC transporter ATP-binding protein EhuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ehuA</name>
        <name evidence="6" type="ORF">GT040_31880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001451">
        <property type="protein sequence ID" value="MYW33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014343">
        <property type="entry name" value="Ectoine_EhuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03005">
        <property type="entry name" value="ectoine_ehuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="31"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="30644" checksum="A83BC2F40F26CBA3" modified="2021-04-07" version="1">MATEPLPLQKTAAPAPQDAVPAAGSTGEPLVRFDKVVKRYGDHVVLDQLDFTVDRGEHVTLIGPSGSGKTTILRLLMTLEKVSDGVIWVNGSPLSHVRTPGGDLKPAGEKQLRESRKKIGMVFQQFNLFPNMKVLQNITEAPISVLGKEREEAETRARELLDLVGLADKVDAHPSQLSGGQQQRVAIARALAMEPEILLLDEVTSALDPELVAGVLELLGDIARNTDITMLCVTHEMNFARDVSEKVLMFDAGRVVESGTPEKIFSDPSHERTREFLNAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN41</accession>
    <name>A0A7K2ZN41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_31910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001452">
        <property type="protein sequence ID" value="MYW33750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="278" mass="31258" checksum="273F7F02BC72B1E2" modified="2021-04-07" version="1">MNLAVKRWAPHTLALVGLLVLLYPLVWLLATSLKPADQVVTSLDLWPSHLEWSNYTTALEGVSGVTVTRLLGNTLLIAGGAVLGNVLSCSLAAYAFARLRFRMSRVMFAFMVATLMLPHHVVLIPQYIIFNQLGLVDSYWPLILPKFLATEAFFVFLIVQFMRGLPRELEESARIDGCGPFRTYWSITLPLTRPALITTAIFTFIWTWNDFFTQMIYLFSPESFTITLALRSFVDQSSTSAYGPMFAMSVISVLPIVLFFFVFQRYLVQGMATTGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN74</accession>
    <name>A0A7K2ZN74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001483">
        <property type="protein sequence ID" value="MYW33814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="32333" checksum="9190F70C27FB0951" modified="2021-04-07" version="1">MTEWDVKKLRILRTLRDRGTVTATAEALLMTPSAVSQQLTNLAKQLGVELLEPQGRRVRLTDAAHLVLRHAEAVFAQLERADAELTGYLRGEAGEVRVGAFSTAVPALVVPAVRLLRAEDRPGPDVRVREAEAAQAYELLTAGEVDLALSLAAHAPTARDPRFSLFPLLADPLDVALPADHPLADAPALRLADLAADRWIFGGSGPWSEITTAACEAAGFVPEQAHSAAGWTAILALVEAGMGTALVPRMASREQRREGVVMRVLEADQPRRHVVAAVRHGAESGPAVARVLSALSRVAESFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNC5</accession>
    <name>A0A7K2ZNC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_31955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001454">
        <property type="protein sequence ID" value="MYW33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="395"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="714" mass="75824" checksum="E47B7B949EBBAA2D" modified="2021-04-07" version="1" fragment="single">ATADALAGCPAGPLTTAPALGDPAYLIHTSGSTGRPKGVLVSHASLANLGAGHLTDHIAPAVARTGRERLRVGHSASFAFDASWDPLLWMVHGHELHLLDDAAYRDPAVLSAYVDTHRVDYLDVTPSYAEALIAEGLLDEGRHHPAHLVVGGEAVPPALWERLTTADAVHPVNLYGPTETTVDAYYWLPGPSADRPEGRPVRGSRVYVLDASLRPVPAGVTGELYVAGPCLALGYLGRPDLTSERFVADPFGALHGTPGGRMYRTGDLVRRREDHTLEFLGRSDDQVKIRGFRIELGEIQARLATHPQVAAAAVIARETGHGKRLLAYAVAEKAGTAPTPNALRDHLAGALPEHMVPATVTLLDALPRTANDKLDHRALPDPEPLAPAIGAEVVGESGPHTEIVRGLYADVLGIAEPPAAEAGFLDLGGHSLLAARLAARVREHFGVPFSIADVFRHSTATAIAAQVRTRSGAATASVPLSPLPRTGPLPLSPAQQRLWFLHRLEGPSPTYNIPLVLSVNGPLDRDALQLALHDLVDRHETLRTVYPPTDNVPEADGDDAPHQVILPPGHEAARPVLRLAEPGSDLTEAVRYCFDLAAEPPLRTVLFSDSPDHHTLLLLLHHIAGDGASTTPLARDLASAYTARAAGIAPEFTPLTGQYVDHAARLQQLLGTPADPTPLAEAQLAHWREALAGLPDQLELPTDRPRPPVATSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZND1</accession>
    <name>A0A7K2ZND1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">GT040_32545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001488">
        <property type="protein sequence ID" value="MYW33874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003969204.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001488.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZND1"/>
    <dbReference type="GeneID" id="6215316"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11566" checksum="C9FF36E26333E9FE" modified="2021-04-07" version="1">MYAIVRSGGRQHKVAVGDIVEVDKISTAKVGDTVELSTLLVVDGDAVTSDPWVLDGIKVTAEIVDHHKGAKIDILRYKNKTGYRRRQGHRQQYTAIKVTGIPAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNG4</accession>
    <name>A0A7K2ZNG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">obgE</name>
        <name evidence="6" type="synonym">obg</name>
        <name evidence="11" type="ORF">GT040_32535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001488">
        <property type="protein sequence ID" value="MYW33872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030563624.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001488.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="160"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="348"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW33872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="478" mass="50942" checksum="9E033D432A515CDE" modified="2021-04-07" version="1">MTTFVDRVELHAAAGNGGHGCASVHREKFKPLGGPDGGNGGRGGDVILVVEQSVTTLLDYHHSPHRKATNGQPGAGDNRSGKDGQDMVLPVPDGTVVLDKAGNVLADLVGQGTTFVAGQGGRGGLGNAALASARRKAPGFALLGEPGESRDIVLELKTVADVALVGYPSAGKSSLISVLSAAKPKIADYPFTTLVPNLGVVTAGSTVYTIADVPGLIPGASQGKGLGLEFLRHVERCSVLVHVLDTATLESDRDPVSDLDMIEEELRLYGGLDDRPRIVALNKVDIPDGQDLADMIRPDLEARGYQVFEVSAIAHKGLKELSFALAGIIAKARATKPKEEATRIVIRPKAVDDAGFTVTLDDEGIYRVRGEKPERWVRQTDFNNDEAVGYLADRLNRLGVEDALMKAGARAGDGVAIGPEENAVVFDWEPTVTAGAEMLGRRGEDHRLEEPRPAAQRRRDRDAERDDAEKEYDEFDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNP3</accession>
    <name>A0A7K2ZNP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea ABC transporter ATP-binding subunit UrtE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">urtE</name>
        <name evidence="5" type="ORF">GT040_33025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001504">
        <property type="protein sequence ID" value="MYW33965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017780">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03410">
        <property type="entry name" value="urea_trans_UrtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="232" mass="24668" checksum="7DF0A3B5D0DFCE43" modified="2021-04-07" version="1">MLEINDVRAGYDRTTVLHEVTVAVPHDGVAAVLGHNGAGKSTLLRTAMGLIRPSHGTVLLDGEDITRLAPHQRVARGMAYVPQGQQSFPHLTTAENLRLVADGSPRGGGRDAIAEALDLFPVLRELAHRRAGLLSGGQRQQLAIARALVTRPRILLLDEPTEGIQPSVVAEIETTVLSLAARGGLCVLLVEQHVGFAMRAAERYYVLEAGRVTSSGEGGTGAERTVREALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP90</accession>
    <name>A0A7K2ZP90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enhanced serine sensitivity protein SseB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001543">
        <property type="protein sequence ID" value="MYW34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB_C" evidence="1">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="12875" checksum="EF99873E00C56F65" modified="2021-04-07" version="1">LDGPASGGRVKLYEPDWQHDPVDFLTAVSAEFEATGVVSTARRALASIEGGDPVLFVGVEFATWDGAGQNAPMDALGRALGRIEVPWPVNLVLLDVAQDLVGDWMREKVRPFYRREGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPA3</accession>
    <name>A0A7K2ZPA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001552">
        <property type="protein sequence ID" value="MYW34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="33290" checksum="CF04871BA3C192C8" modified="2021-04-07" version="1">MTSTDAPAAIAPAPPVLAEVVRSGFTEGHHRGSLVLLAADGSVEYALGDPAAPVFPRSSNKPMQAAAILRAGLELSGERLALAAASHSGEPFHLELVATMLAEHGLSADDLQTPPDLPLDPVAAEVYLAAGNVRERITMNCSGKHAAMLAVCVRNGWDTASYLDPAHPLQLLVGQVVAEAAGEPVASLGTDGCGAPLMAIGLTGLARAFRSFVLAEPGSAERRVADAMRAHPEYVAGTRRPDTWLMSEVPGTLSKMGAEAVQAVALADGRALAFKIDDGSTRALGPVLARALELLGVDAPVVARIGRSPLLGGAAEVGEIRATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPI2</accession>
    <name>A0A7K2ZPI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001584">
        <property type="protein sequence ID" value="MYW34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="351" mass="36599" checksum="CFD937463660A192" modified="2021-04-07" version="1" fragment="single">MSGLTGGDPSLLRRINSAVVLHALRGAGSPTLTDLTRITGLSRPTVEGVVEGLFEAGLVVEALPDESEARRQGRPARRFRFRAEAGHLLGVEIGPHRVSALLSGLDGRVTGAGSRAVSETADADERLDHVRAVIADLLRRTGVARSSLRAVGVGSPGIVEADGTVRLGTALPGWTGLALGERLRRSFRCPVLVENDANAAAVAEHWKGAATESDDIVFVLAGLSPGAGSLIGGRLHRGFGGAAGEIGALHLLGRDVTPEHLLSTTGTPLEPLDEQAVAAVFAKARQGDEEAQAAVERFLHRLVHDVAALALALDPELVVVGGWAAGLDGVLEPLRAELARYCLRPPRVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPP2</accession>
    <name>A0A7K2ZPP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ORF">GT040_34745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001589">
        <property type="protein sequence ID" value="MYW34297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="270" mass="27635" checksum="AA1C6B85A8BB16EE" modified="2021-04-07" version="1">MSGNIELLSTTLAAARAEDRAALIAYLPAGFPTVDGGIEAVKAVIAGGADVVEIGLPHSDPVLDGPVIQTADDIALRGGVRIADVMRTVREAYEATGVPILVMTYWNPIDRYGVERFTAELAEAGGAGCILPDLPVQESALWREHADKHGLATVFVVAPSSQDARLATITAAGSGFVYAASLMGVTGTRASVGAQAQELVGRTRATTDLPVCVGLGVSNAEQAAEVAGFADGVIVGSAFVKAMLDAPDEAAGLDAVRSLAGELAQGVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPX1</accession>
    <name>A0A7K2ZPX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001595">
        <property type="protein sequence ID" value="MYW34338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22136" checksum="CE6D969AD8CA2F7C" modified="2021-04-07" version="1">MLSEPIRRVLDPERDGVAFKALTHPLRIELLGLLRQHGPATVGEPAARTGESSASTSYHLRVLAKYAFVAEADHRDSRERRWKAVRSATSWSNEAVHRAPGGRAALSALRRQLEHLERSPARHADDLVSGRLDSAWQAPSGLSDSLPRLTPESLAELWETLAAKTAELTARHADDPRAEQVVVFTAGLPLAPEPAPDAEENAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ03</accession>
    <name>A0A7K2ZQ03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurite resistance TerB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001622">
        <property type="protein sequence ID" value="MYW34415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16520" checksum="B9C56C8079493521" modified="2021-04-07" version="1">MALWDRIKESASSMQTQLEAKKNDLKSGAFRDASMAMCALVAAADGSIDASERQRVAALISNNDVLKNFPADDLQRRFNDYLNKLTADFDFGKVSVLQEIAKAKKKPAEARAVIQIGIIIGGADGDFDKTEQAVVREACFALDLPPHEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ19</accession>
    <name>A0A7K2ZQ19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001625">
        <property type="protein sequence ID" value="MYW34466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="315" mass="33541" checksum="B7AE182C5B270CA8" modified="2021-04-07" version="1">MTEREPVDRVYLRHSTDKQTDARQRHSLKKLIAAGAPVYEDPATSSRVLSLNREGFKRLLEEAAVGDTIRIADAARLFRSVADVLALRPALARRGLHLRVENGLLSGIDLAAEDSATTMVVQVLAAVLEFQRSMISENTREGVAAAEAAGKTLGRPAALDAGEVVELVEAYREGAAVKALARQYGVDPRTVRRVLDDAGAREVPDDLVVPGEEATTPAGGPDGGREQAADPVVAVDVPGLVAEHLVDVADEPVRQALAAGQTIRRGQGYSVRVTAPVSVHVAMVEHSATALTHSPAGRKAHRIHSDRVTSVRITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ35</accession>
    <name>A0A7K2ZQ35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_35570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001624">
        <property type="protein sequence ID" value="MYW34452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2108"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1053"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="2457" mass="265043" checksum="923A1ADA7517EEEB" modified="2021-04-07" version="1">MAEDIQALRDHILRSRLEGTGTSAVLTPLPARTTPAAPAESAAGPGRSVPLSPSQRRLWFLDSIDPDSGEYHVPMVLRLRGAVDASALRRAWARVLERHEVLRTRYRMERDEPVQEVTGSPESELVLSDLRATAAGDRESRAQELVRRLAHSPMALAEGRVARAGLVTVADDDHYLVVSIHHIAFDAWSEPILWRDLAHAYRAETGDGGAEFTPLPTQYADYAERQRTQLLDGTLAESLAYWKRQLSGMPPLELPTDRPRQAVRSSAGTSLPITVPPTVAKAVRAAAAEHDTTPFLVLLTAFQVLLSRYTGRRDIAVGIPVAGRDERATQELIGCFVNTIVIRTAWSEDPAFSDLVRSNKSRFLDAVEHAQVPFDVLVNELAPDRDLSTPPLAQVMFSYGDGDPDGIALPGVETVRIPTLSESSKLDLTLQIDSEADGTMSGALEYSTALFEPDTVRRFVDNYFQLLESATDSPDQRLSELRYITEQELAKLLATADGGTADRPRGALHELIAEQARTAPLSPAVLSGDTSLTFGELDAGANRLAQHLRSLGVEPGSVVGVHLPRDARLVIALLAVLKAGAAYAPLDPGDSATRRGYILSDAGAQVVVTDEAGAGSLGQGLDGRTVVLVDSDAEVIGARAADDPALPVAPDALAYIIYTSGTTGLPKGVMVTHRGLMNYLWWTVDTYLRAPGGTALFSSAAFDLGVPNLYTSLLRGRPVHLLPDGEPAELGARLLECAPLSFVKMAPGHLELLAEQLDPAQRRSLAGLVIAAGDRFTGTLANSWLADAGPGSVAAEYGPTEITVGNSGCRIERPVGTELVSIGTAIPGTTMYVLDEHLRPVPFGVVGEVCIGGTGVTRGYLDKPRLTAERYLPDPFSTEPGARLYRTGDLAAVRPDGDVNFVGRVDKQVKIRGYRVEPAEVESTMAAHPAVRTAHVTARQTDGGRPELVGYVVPAVATAAPDQAALRAFVGERLPEYMVPSAIVVLDSLPLTDVGKIDTDALPAPDRASRGVSTDLVAPRSDAEEEIAAAWRTVLGATEFGVRDSFFLIGGDSVRAVAVVGALRREGYAVTVQDVFEHRTVEAFARILGPRSAQSVDAPVVQPFEMLDPADRARIPDGVTDAYPLSRIQLGMILEMESSGSEGNYHNVTCYLVRDGRPYRHELLQAAIDATVARHEVLRTTMDLTTYGEPLQLVHSEAHLPVGFADVRGLSPEAQREEVRAYMAAERGHRFDLSTAPLFRYFTHMCEDQWWVTFTEFHPILEGWSFHVLLSEVFDRYHALHDATEYVPKPLPQIRYADFIALERKDLRDPAHASYWRDVVANHAKLELPSAWGDGSGPVKQLVTPYDDLQDGLSGLARAADASLKNVMLAAHLAVMSMITPDQAFSTGLVCDTRPEAEGADRVPGLYVNTVPFPFRRGARTWRQLVEQVRDTEVEMWPHRRYPLGEIQEGSRHARMVDVAFVYLDFHVLDWNLIDDDAVVDESPNEFRLMAVAQTGRLTVYSRPGDAGPHAQALLGTLYRTVLEAMAADPDGATHEVLTPRTYRSIAYGPESAAALGERAPAPATTPAEEMSVHGVVERQVARTPDAVAVVCGKDRVTYGELNTRADRLAHRLTAAGIGAEAVVAVHLERSVDLVVAYLAVLKSGGVALPVDPEYPQDWRRSLLAQAAPAVLVTEEAWLPELGDTGIPAVCLDTEPDVPAGDDAPVPVNWHGGDQLAYMIYTSGSTGRPKGVENTHRGLLNTLKWGQERIPLGPDDAVLQTVPISFDVSLWEIFRPLTVGSRLVLAEPGGHRDTHYLADLVADERITVIHPVPSILAIFLDTPELARRCGSLRHIVPAGEALPVELQQRAMRELPWIRLHNHYGPAETAIIATAWECEADDGRTTVPIGRPIGRSWALVCDSDLNPVPSGAVGELCLGGDLMGRGYNAAPALTADRFVPAPLGLPGERMYRTGDLARMSPDGVIDFLGRVDRQVKLHGVRIEPGQIESVLVEHPAVRDAVVVVDGTGGGKRLLAYVVPDAVTAAPVRRQLADAADAAPEPQDGTAEATWTNAEELVADVRRRCQEQLPPALVPSALILMAAFPLSHNGKLDQAALPAPSAAPAGPQSAPRSRTELDLLHIWERVLPNRSIGIEDDFFEAGGNSLLGVRLISTIRKELGIDLPMASLLDASTVAAQAASLVARRPRQPRTLVPLRLGTGRPTFCVAPVGGTAFCYLDLARSLPGDGPVHGLQSVGIEPGEHPLTSVADIAAAHLAVVREAQPEGPLRLIGWSFGGLVAYEMARQSAEAGEQVELLAMIDPAFPPPLLPGAVSTGAEEEPEVIAAYLTFLDRLHEVDMALSAEKLAAMPSADRRRELVTRMRDAQLIPADATTGEELRLFEVFSANWRALGEYRPLPHPGRTLIFSAGDAAEDERASAARRQWLRLCTGDTTALALAGDHYAAVKAPNTATVARSVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ50</accession>
    <name>A0A7K2ZQ50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001607">
        <property type="protein sequence ID" value="MYW34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14116" checksum="D0EE2370006CD900" modified="2021-04-07" version="1">MRSGITDADGHDVPVAVAPGEAGPDPRVSVTLTPPAGELRWSCTPAAARELAAALVRAAEETESASDEGPVTVPAGELRRGDVRDGDRSMTVDGVRIDGSTAHVTWRSGAGRTWNQSYDVNTAITLRRRLPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQL6</accession>
    <name>A0A7K2ZQL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Squalene synthase HpnC</fullName>
            <ecNumber evidence="1">2.5.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hpnC</name>
        <name evidence="1" type="ORF">GT040_36265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001644">
        <property type="protein sequence ID" value="MYW34588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004310">
        <property type="term" value="F:farnesyl-diphosphate farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017827">
        <property type="entry name" value="HSQ_synthase_HpnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480:SF17">
        <property type="entry name" value="PTHR31480:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03464">
        <property type="entry name" value="HpnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="33029" checksum="9F9BF9899BDDDFFA" modified="2021-04-07" version="1">MTSTPEARTGDATLGKAADENFPVAPFFLPRAWRDDLMAVYGYARLVDDIGDGDLAPGGADARHLGLEPDQSDDRLAMLDAFETDLHRVFAATGQEPHHPLLRALRPTVRRRALTPEPFLGLIEANRQDQKVRRYATYGELAAYCELSANPVGRLVLALTGTTSPERVRLSDAVCTALQIVEHLQDVAEDLARDRIYLPAEDMDRFRVTEDDLARPSAGASVRALIAYESERASELLRDGIPLVGSVDGRLRLLLAGFVGGGRSALTAISAAGFDVLPGPPKPTKPSMLREAAVVLRRARRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQM9</accession>
    <name>A0A7K2ZQM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_36170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001641">
        <property type="protein sequence ID" value="MYW34569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="entry name" value="PTHR46313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="566" mass="63366" checksum="10B487A45EB9BA6A" modified="2021-04-07" version="1">MADDPSTPRDTADDWTSRERTPGTPPRVIIIGAGVAGLSTGCYAQMSGARTRIFEKHVLPGGCCTAWSRDGYLFDYCIEWLIGTAPGNDAHQVWRELGALDGKTVTNFELFNKVEDESGRSVTFYNDPDRLEAHLLAISPADAPLIRAFTRDLKRFIAIDLYPFLTAPALRTVRERAATLRTVLPAFRLFWRTAATPMHVFADKFQDPLLRRAFRNIFFQDPEGFPLLPYLFNMAAAYHLNAGFPQGGSLGLSRSIEERYLKLGGHVTYRARTEKVLVENDRAIGVELRNGKRYFAEHVVSAADGRTTVYGLLGGRYTGPRIDKLYTDLLQRPGTLFPAVVSAFVGLRGDFDPGEAHSTTHLLTDEDGKQLPGALQNSLVVQARSRYSDGFAPPGRSVLHCTYFSDYAYWKELRTRDRKEYRQRKHEVADFVRTFLDRRSPGITDRIDLVDVASPATTHRYTGNHNGSILAWKAFSDADDVSARLVAKDRMRLPGLTGFSMAGQWVGMGGLIRAASTGRFAVQYLCRELGLEFRAWESEATEPWHTGKLGHLPQLDRWSAREDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQP0</accession>
    <name>A0A7K2ZQP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1015 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001678">
        <property type="protein sequence ID" value="MYW34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="425" mass="46734" checksum="7506B9C1507C6A04" modified="2021-04-07" version="1">MNTSGPDEQGLRLIPFRGLRYVPERVGSLAAVTSPPYDVVVRPDGLHHLESADPHNIVRLILPQADTAEDRHRQAARTLERWLAEGVIAPDPAPTLYVYEQRDDEILQRGLIGALALSPAADGIVLPHEDVMDDIVADRAELMRTMQAHLEPLLLTYRGDGAEEGAAAVIERTAERPPLLSTTTEDGFHHRLWAVTDSAERTAIETDLARHQALIADGHHRWATYLRLQREQTAPGPWDFGLVLLVDTTRHPLQVRAIHRLLRGLPVARALEGLSGLFRVRTVEGPLPRALDALAGAAAEDNAFLLAGDGGFHLVDRPDPALLARTIRTDRPEAWRTLDATVLHSALLDDVWRIPDAPGHIGYIHDTEAAVEQAERLGATAVLMHPVREEVVRDLARQGVTMPRKSTSFGPKPATGLVMRSLTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQX4</accession>
    <name>A0A7K2ZQX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8415" checksum="FF80456F4032F4E8" modified="2021-04-07" version="1" fragment="single">MSVDTRTPRFDEQPALSMTKVDSDPAQVIVNHASFRVQLAPGQRARLRGLADTARIPAMSGAGAGGGRRRAPVVWSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR66</accession>
    <name>A0A7K2ZR66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001699">
        <property type="protein sequence ID" value="MYW34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="12579" checksum="42BBDA983CC2D716" modified="2021-04-07" version="1">RVTTDKGLPKRTPKVVRPEGAPTTGRTGSLDKDDLRRRLGSFHQAAKEGRRDVEAEIAESTGSVALADHEGVATGRTGHETTTAPVTGTAHDTGTTEQTGGRTDRRNGETGDTVEEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR85</accession>
    <name>A0A7K2ZR85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_37160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001684">
        <property type="protein sequence ID" value="MYW34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003967913.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001684.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="172" mass="19012" checksum="D1C0AD5E750A0B2B" modified="2021-04-07" version="1">MSELTLTVMRLGFLAVLWLFVIVAVQVIRSDLFGTRVTQRGSRRTAADARPQQGRQQQQAAPPQQRQQPGRQRRGAPTKLVVSEGTLTGTTVALQGQTITLGRAHDSTIVLDDDYASSRHARIYPDRDGQWIVEDLGSTNGTYLERTRLTTPTPVPLGAPIRIGKTVIELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRM0</accession>
    <name>A0A7K2ZRM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001752">
        <property type="protein sequence ID" value="MYW35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="15929" checksum="7C9C021A203AAE22" modified="2021-04-07" version="1" fragment="single">MSREQRGPNEKLGTVLALAGISNAGLARRVNDLGAQRGLTLRYDKTSVARWVAKGMVPQGAAPHLIAAAIGAKLGRPVPLHEIGLADADPAPEVGLAFPRDVGEAVRSATELYRLDLAGRRGGGGIWQSLAGSFAVSAYATPASRWLITPADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRZ6</accession>
    <name>A0A7K2ZRZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001781">
        <property type="protein sequence ID" value="MYW35154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7675" checksum="CAF88E376C785CF9" modified="2021-04-07" version="1">MPSITSSKVTRWDQHGREHVVRVRKSGMSRELTCSTCGWRRSAQFLPWLKAQEHLTEAHQATVDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSU9</accession>
    <name>A0A7K2ZSU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001849">
        <property type="protein sequence ID" value="MYW35425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="859" mass="91554" checksum="C67AB542DB0EDA22" modified="2021-04-07" version="1" fragment="single">RGLDPRRAAGALQRIRDAVMFHLPMQDAIEAGLAPDGLGTRTPDNLGGGYRLPPFLQRRHFPSHPSGQLDASRAAQQLMGQLARMGVPSHDREQVLQRLSPDFLRSHVHELTTDGVTLPVRYRSWSRPHQLPVGGSPGQLKLTLTPVTTTVERLRTGYELEDYRTTARDDVDGRSQDRGADATLSGSERVADGGLLAANPAIQGTAAKQRSSNVTESAGATAMPNIATTQAHAEIVTTYTLTATLVDASGQPLGPTATAPVGSLNEILPASLLTPDGEGTDGALTEQDVPEPRREVQLLTADQARAESVAQWRTTDGETGERDPDILPFDDVIGSGILAVDIRGAANVQDALTLATARADGSPGDLDLGERHTGTTLAERVRMARHTPLTGLGTAPAQAQQEATSQVGLTAGFREALGPDGSPLPTQSSARLLKQSHTADSRLYAKMHRDGARLLAVENKPRMEAMQRRKTGDALDAGITDNIEGAVSTSPLAGNSNAGVTNPGATVPIGGANDSTALRGATDTTLGTHIKVVTDRSMLFAIPVSWLAVAEVDHRVTDSRPMQALGKPKRGPRAAEAETTALVWLREDIARDYGLLDDTTFPDEARAAWDAQAKATADLATAEKNYYDARAKARETWLGLSPEQQAALGDDDRVTVLPRAVAESPAVTAWQAAREEVRTWQQRLDAAAKDHHRLQLAAARLTAHHQGSGSVPVKDAPQEYTAPDWRSEAPEPYKVTEAGGSTPRTLTSPDGRTVHEVHEVPHDGASFFHALLTTAQDRGRLAFLLDADLADRFTAAPGDPAVTAEAVGAVRNRLAWALGDDRNGDLLDGLALDTADTFSQVELDFAEVELTPAQQAEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5U3</accession>
    <name>A0A7K2Z5U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uma2 family endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="20599" checksum="0D2A162AF58E84E4" modified="2021-04-07" version="1">MSVEEFEQLARSAPETVTLELVNGKLVVKPVPDGDHGTIFMWLLRQCMQHRPDLDLHPEQGLMVEAYRQGRARPDGALAPRRHFAGQGGWAPAEGVLMTVEVTSYDRDTDRRDRYEKPHGYAAAGIPVYLLIDRESGTLVVHSEPDKGRYRQRLSYDYGDTVALPHPVDITLDTEELKDYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Y5</accession>
    <name>A0A7K2Z5Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_00100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW27713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="466" mass="47933" checksum="796055A07435ED9B" modified="2021-04-07" version="1">MIALTQLVVVLDATIVNVALPQAQRELELSDTERQWVITAYVLAFGALLLLGGRIADYWGRKRSYMVGMLGFGLASVWGGLAQSGTELIAARGLQGAFAALLAPAALALLTVTFPAGRERGTAFAVFGTVAGTGAAVGLALGGVLTEFADWRWCLLVNIVFAVVGLVGALLFVSESRVEGGNGYDIRGTLAVTLGLAALVYGFTLAETGWTEPDTIGFLGAGLVLLAVFVRIEARAAQPLLPLRIVRDRARAGAFLIQATIGAVYIGMTLYLMFHLQIVLGLSPLLAGLASLAMTFATMITAPVAARLLPTRGPRVLMTGGPLIAAAGMLWLTFVTADGSYWTEVFGGLVVVGIGIAFVIIPVQNVALVGVDHHDAGAASALVNSAMQIGGCVGLSVFTTVYLGAVERSAAVGDGGVTALTEGHSAVFLATAVTLVVAAVIAATMLRGPRPAAAPDQLAETPAHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z601</accession>
    <name>A0A7K2Z601_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000011">
        <property type="protein sequence ID" value="MYW27769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="19196" checksum="E65FB54AEBA2AFCA" modified="2021-04-07" version="1">MTDDHRVGPPSFGTERETLRAFLDYHRATLAMKCEGLTDEQLREKPMEPSALSLLGLVRHMAEVERAWFRRTFEDRDAPMVWSEKIDFQAAYDASTSTRAEAFTAWEAEVGISRRIEREAGSLDLAGYQPRWGEEVSLRMVMVHVLLEYGRHNGHADLLREGVDGTVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z634</accession>
    <name>A0A7K2Z634_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000013">
        <property type="protein sequence ID" value="MYW27782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="11775" checksum="9FF4A68A98ACD213" modified="2021-04-07" version="1">MHITTELHGRGATLTPRGDIDFGNLGQLQACLTGLPDTVTEVIWDLHAVTFADIAGLHLLSTPTAPAQVTLTNLTPSFTHLLEVATAAFPDQEWDRHLPTPAGQGAVRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6F9</accession>
    <name>A0A7K2Z6F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000057">
        <property type="protein sequence ID" value="MYW27926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="16214" checksum="DCBF1EDE6766AF81" modified="2021-04-07" version="1">MGVNDSLLLPVADEDGAPFWEYAARGELRVQTCAAPACGELRFPPRPCCPHCGSFDSAWRVMSGRGRLWSYVIPHPPLLPAYAEQAPYNAVLVELVEAPHIRLAGNVVASADAPLNSVAPGRLRIGAPVRAVFCPVGPDGFTLVRWLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6X6</accession>
    <name>A0A7K2Z6X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000085">
        <property type="protein sequence ID" value="MYW28063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S15" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="63" mass="6354" checksum="D2AA0D2A626F6B07" modified="2021-04-07" version="1" fragment="single">MNTTASTTTKTSASTATDTTAGITTVYVPAPDGTPLATDLCLPATPGPHPAIVIRTPYGRTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z772</accession>
    <name>A0A7K2Z772_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_02495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000109">
        <property type="protein sequence ID" value="MYW28168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006125578.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000109.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="13"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="16090" checksum="AB88BB679A9A3151" modified="2021-04-07" version="1">MGVMSGPYVIRGSVSLPEAELMWRFSRSSGPGGQHVNTSDSQVELRFDLAATDALPEVWKARALERLAGRLVGGVISVRASEHRSQWRNRETAAVRLAALLAEATAPPPKPRIKRKIPRGINERRLREKKQRGDTKRGRSGRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7J6</accession>
    <name>A0A7K2Z7J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="10325" checksum="A0B9847F15520BAF" modified="2021-04-07" version="1">MKDWYIHDRVESVRFFWYPGRRIDRWPLLRLGNEENCNKVLSIRIPGGALNICLNTPLRQKPCAPCLAEERAWVWDRPARRMKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8N1</accession>
    <name>A0A7K2Z8N1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000225">
        <property type="protein sequence ID" value="MYW28655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="264" mass="26588" checksum="43750F86DC109DDC" modified="2021-04-07" version="1">MDWPTGLLGFAAGLLISVTTAPVGVSGAVFLLPVQVSVLGVPSPAVTPTNLLYNVVAGPGALLRHHRSGGLRGPLTRLLVLGTVPGVVVGAVIRVFAVPGPSVFRLLIAVLLLPLGGWLCLRTLHRAARTAAAREPSEVSPRTITRLAMAVGVAGGVYGIGGGSLLGPILVGRGMPVAKVAPAALAATFVTSVVGAGTYALLSLTATGDIAPYWSLGLVCGLGGLCGGYLGARLQPRLPETVLRLLLGVLALGIGGLYAIQIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Q7</accession>
    <name>A0A7K2Z8Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000247">
        <property type="protein sequence ID" value="MYW28713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029578242" evidence="4">
        <location>
            <begin position="39"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="263"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1009" mass="108605" checksum="635110D610893F23" modified="2021-04-07" version="1">MRRTSRRLSGRRPLAAAVAAAGLLGLLTAVPPSDPAPATAPVAATAAAETTATVFYSTKTRNWSAYHLHYAPDGGTWTTVPGTRMASACTDWVKLTVPLGGASGLKATFNDGSGTWDNNAGRNYDLGTGNITVKDGVVAHSDPCAGTDPEEPAPGGPNTASVYYATSTVGWSTVNLHYRPHGGAWTTVPGVGMEAACTGWVRRTVDLGSATGLQATFNNGNGVWDNNNGSDYTLPAGLTTVKDRKVTATAKDPCAAEEPDTEAPSVPTAVKAAADGVSVLVSWEPSTDDRGVTRYQVTRTGGTKGSFVTDVGSTVFADTGLEAKTAYRYTVRAVDAAGNLSAASAAATATTGEKPTAPATGTPLGTDPRKDPIYFVLTARFNDGDPTNNRGGSQHEKSGNAANNDPMFRGDFKGLVQKLDYIKGLGFSAIWVTPVVLNRSDYDYHGYHGYDFYRVDPRLESAGASYQDLINAAHAKGMKIYQDVVHNHSSRWGAKGLFTPKAYGVRDAQWSWYYDERNDGFAYDGLTVEPKSGKSYYNGDLWSTAEPTGNTCVGWGTPTGHTSPEGYRIYNCQWPSPTSGMFPKALYHNCWIGNWEGEDSRSCWLHDDLADFNTENAQVQNYLIGAYDKYIDMGVDGFRLDTAVHIPRTTWNRRFLPAIQERVTQKFGAEAAKNFFVFGEVAAFVNDKWNRGSVNHSAQFFTWKERKEYSADDEKAALEMYDYEQQQGTGAQPVSDNAFLKGNAYHAPDRGRFSGMNVIDMRMHMNFGDADNAFHNGKDSDDSYHDATYNVVYVDSHDYGPNKSSERYTGGTDAWAENMSLMWTFRGIPTLYYGSEIEFQKGKQIDCGPRCPLASTGRAYFGDHLAGEVTAPDFGKVSSATGKVADTLAAPLARHLQRLNEIRRAVPALQMGQYSTEGITGSMAYKRRYTDAASGDDSFALVTVSGSATYTGIPNGTYKDAVTGDTKVVSGGTLAVPAPGKGNLRVYVLDLGGKNAAPGKIGAAGPYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8S8</accession>
    <name>A0A7K2Z8S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_05560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="79"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="348"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="461" mass="49036" checksum="5C38022E0956FB95" modified="2021-04-07" version="1">MRVATGLSVLVLGAGGIGHAVVSGLEGGIGRVDPFKDMKNRPQSGHGTNLLLVGTDGRDTITKAEKQKYKLGGAPCHCTDTIMLVHLSADKQRASVVSLPRDSYAEIPAHTDRTTGKKHNSHPVKLNAAYAEGGPTLTVRTVEHMTGVKVDHYLEVDFTSFMKTVDAVGGVQICTARPMKDSYTGLDLPAGTHRLDGGRALQYVRSRHVDVGSDLGRMQRQQKFMAALIKEATSNGVLLNPVRFQQVSASVLGSVRADEGFGTEQMLELGKAMKDFSPASSEFTSVPIGNPSFPVKGIGSTVQWDAAKSKKLFQALREDKPLAPAKPKPAAGAPKKARATLVDVAPEEIRVQVYNGTPKDGLGKDVDAGLRATGFNTTDAPLNGKLRDLARTLVTYDPRWDRSAKSLAAALPGSELKAVKGQGATMEVTAGSDFTKVRPVRAETKQTGEFATVTGDEVVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Z8</accession>
    <name>A0A7K2Z8Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000255">
        <property type="protein sequence ID" value="MYW28803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="16335" checksum="1BF2E62F9DC48A1F" modified="2021-04-07" version="1">MSTEFEATVIIDRPVDAVFTYLADGRNDPDFSPRVLKIDKSPDGATTAGTVFHSTVKDAGMRTQRDFEITELTTPTRIRWREASHNPITVWEGGYDLEPDPGGGTRVRLFNVLEGHGIGRLLLPLAGGASRKDAPDFGRRIKAAAERAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z940</accession>
    <name>A0A7K2Z940_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAD-IC family P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_05895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000257">
        <property type="protein sequence ID" value="MYW28815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="832" mass="88176" checksum="3F91A54AABABC663" modified="2021-04-07" version="1">MTQRALDSSGEQTPGPSRPAMIDAGAELDPVHPMDLPPSAHDATGLTTAEVAERVARGEVNDVPVRSSRSVAEIVRANVFTRFNLIIGVLWVIMLFVAPIQDSLFGFVIVANTGIGIIQEWRAKKTLDSLAVIGEAKPTVRRDGKAAEISTHEIVLGDVVELGPGDKVVVDGTVAEADSLEVDESLLTGEADPVLKRPGDAVMSGSFVVAGGGAFTATKVGREAYAAQLAEEASRFTLVHSELRSGISTILKYVTWMMVPTAIGLIISQLVVKDNNFKDSVARTVGGIVPMIPEGLVLLTSVAFAIGVVRLGRKQCLVQELPAIEGLARVDVVCLDKTGTLTEGGMDITEVRPLGGSDEAYVHQVLRSLGSSDPRPNASLQAIIDAYPAGGKSDKGEQGEEASWAVTDALPFSSARKYSGAAFTETDGTSSAWLLGAPDVLLPEGDPTLDEIELLNQQGLRVLLLARVPSGELDAPDAAEGDVPTALVVLEQRLRPDAAETLKYFAQQNVATKVISGDNAVSVGAVAGKLGLAGAENTLDARKMPTDPDDMATAMEQNAVFGRVTPQQKRDMVAALQSRGHTVAMTGDGVNDVLALKDADIGVSMGSGSEATRAVAQIVLLNNSFATLPSVVAEGRRVIGNITRVATLFLTKTVYSVLLAILVVCTQVEYPFLPRHLTLLSTLTIGVPAFFLALAPNKERAQPHFVRRVMRYAIPSGVIAATATFTTYLVARHHYAGPGALEAETSAATLTLFLTSMWVLAIIARPYTWWRIGLVAAMGLGFLIVLVVPWLQDFFALKLVGTTMPWTAVGIAVAAAVLLEFSWRLVGRRFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z989</accession>
    <name>A0A7K2Z989_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000293">
        <property type="protein sequence ID" value="MYW28892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="295" mass="32138" checksum="44EE6088DFB71F6C" modified="2021-04-07" version="1" fragment="single">EEVARSGLAVAEAHRRLGQVEEADRAWKASYRAARSAGATGAMAWALWSGGTLARQRGSLRLAFRLLWLAAELGKRGGDVVARGYSLAGLAETGRIQGDYETVATLHEQLLAEARARGEARHTVWALEGIAQIHRNTGQLDSALGMFEEAAVLAGDADDRRGRAWALRGIADIVSLRDGATERALGLLAEAEVTCREMKLSSALAYNHKMRANVLFRAGRYEEAREVYEQALGEFRAMTEPRGEALAALGLVKARARLGRDRADTASELDELRGRLSRIGLLNAREMVEKAYAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9C2</accession>
    <name>A0A7K2Z9C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000301">
        <property type="protein sequence ID" value="MYW28960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="40"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="245" mass="26336" checksum="05BEDF69CA3DD6C4" modified="2021-04-07" version="1">MLDYDEEARRYDASRGGEPRARAAADAVERLLPGGPCVVLDIACGTGIVTERLRRPGRTVVGVDRSPGMLGLAGRRMPGGVVRGDATRLPCAAASVDAVVIVWLIHLLPDPEAVLAEAARVLRPGGVLITTVDKNDAYFTEDSDIARITAELRHRHAPQVSDRSARVLGAAADLGLEPTDRTEFPGIGQGRSPRSWCEAIDAGFILWCTHASPDQVADVRRRLAALPDQDVARPDPQYRLVALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9V6</accession>
    <name>A0A7K2Z9V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11263" checksum="4963800C02BC1171" modified="2021-04-07" version="1">MAVAVKDVPEAKRYEARIEGESEVAGFADYLRTAELIAFLHTEVSPRHEGKGVGSALARTALDEARAAKLRVLPTCPFFAGWIARHPEYQDLLYQSRSSVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9W2</accession>
    <name>A0A7K2Z9W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_07465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000353">
        <property type="protein sequence ID" value="MYW29118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW29118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="278" mass="28103" checksum="04B614907EA10767" modified="2021-04-07" version="1">MRRVAEQTALSESTGAIGAISVGPPGPTAPGASPGKPDAAVVRDALAVGIAVGLSGFAFGVTAAGSGLSLLQICALSLFVFTGASQFALVGALAAGGNPYTAAAGAFFLGVRNAFYGLRLSQLLALPRALRPFAAHWVIDETTAVTVAQPDRRSARLGFTVTGLTLYVLWNLTTLVGAMGAEALGDTEAWGLDAASPAVFLALLAPMLRSTTERVTAGLAVLLALTLLPVLPAGVPVLLSALAAPVVLFLMGRRKRGPAVEGGTATREKTTEKGGRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Z1</accession>
    <name>A0A7K2Z9Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_07485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000354">
        <property type="protein sequence ID" value="MYW29122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="252"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="347" mass="38308" checksum="22B6DDCA47CF6C8D" modified="2021-04-07" version="1">MASEPDKTSLSEVRLSEEVLRRYREALEAGTISGDVPASLVRSGLVRPLPGRRDVYVPVPPGIAESLLARHVERDIEERRKSLEVLHSSFLAAEAVYRKAQRRAELPIESLNGEEVIGEALRKAVGSCKEELLTAQPGGGRPPALLAEALPRDLALLRKGVRQRTLYQHSVRSHAPTLAYIEQVLAEGARVRTVDEIFERVIICDRAIAFIPGTTERKSTALALRHPGVVEFLAKMFDHAWERAEPVAISVERHRPDLLTSSVRRTVLRMVVTGHTDESIASRLGMSARTVSTHIRKVSEALGSRSRAELGYLLSQRRLLEQGSALPGEAPGSPTRQRRQATRESCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA14</accession>
    <name>A0A7K2ZA14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tellurium resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000342">
        <property type="protein sequence ID" value="MYW29105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="209" mass="22529" checksum="9A913995F5543529" modified="2021-04-07" version="1">SKVTLTKDAPSVSLAKQGGTSGALRVNLNWEVRKQFKGWGAKLGRAVAMHGDLDLDLCALYELTDGRKGVVQALGNAFGSLAQPPFIHLDGDDRTGALSTGENMTVNLDRKDLLRRVLIFVTIYEGARSFADLHATVTLQPQNGAAIDFSLDECTVPSTVCALALITNNGGDLTVQREARYLVPDRGVSPQRTIDAAYGWGMNWTPGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA71</accession>
    <name>A0A7K2ZA71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sph</name>
        <name evidence="3" type="ORF">GT040_08025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000368">
        <property type="protein sequence ID" value="MYW29228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09078">
        <property type="entry name" value="nSMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017766">
        <property type="entry name" value="Sphingomyelinase/PLipase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03395">
        <property type="entry name" value="sphingomy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029609098" evidence="1">
        <location>
            <begin position="33"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="35659" checksum="CB84353F6F4B6CCF" modified="2021-04-07" version="1">MPHSTFRRLSGVALSAALAAVPLAVHTPQAAAATTADTPSLRVLSYNAFIFSKTLYPNWGQDHRAAEIPKTSFFRGNDVVVIQEAFDNGSSDALLRNSAAQYPYQTPVVGRSKSGWDATSGSYSATTPEDGGVAILSKWPIIRKEQYVFKDACGGDWWSNKGFAYTVLNVNGTRVHVVGTHAQSTDPGCSAGEAARMRSLQFKAMDAFLDAKKIPAAEQVIVAGDFNVDGHSAEYASLLKDADLTAADTKTGHTYSFDTRDNSIAAERYPNDPREDLDHVLHRAGHARPAGWKNDVIKEQSAPWTVSSWGKNYTYTNLSDHYPVIGSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAP2</accession>
    <name>A0A7K2ZAP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,6-dimethylbenzimidazole synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000405">
        <property type="protein sequence ID" value="MYW29372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="20592" checksum="AA245A8A56204147" modified="2021-04-07" version="1" fragment="single">MTDTGQVPGEGLPENAGMVEQPGIPAPDAYTFLDPSEHAPEDDDLLLMPTSQGAWSDPQTVQTPAAPQPQAAAALTPQAPAAQPSAAQAPAAHAPAAQASAAPAPAAAATEQAAQQFPAPHQEPQYATRPQVPGQGQEVTLPAEAYGTHESGGRDTGSVDLDGVRIPAPAPAPAPVQTPTPVGAHAQAASAPARRPLHRGPASAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAR7</accession>
    <name>A0A7K2ZAR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_09040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000412">
        <property type="protein sequence ID" value="MYW29418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="12098" checksum="E5E952B5C96DB6C7" modified="2021-04-07" version="1">VRAPVLGPSRQHEHSESLSQLQPLVGQSSVSGGSVSPPNRQQYGLSSREVEVMELIASGMSNQQIAATCFISEKTVKNHINRIFTKLHSTSRSEAIARWLGTAPRDPGRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAT9</accession>
    <name>A0A7K2ZAT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_09060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000413">
        <property type="protein sequence ID" value="MYW29422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512361.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000413.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="22326" checksum="F0094DB7C5AF7BD9" modified="2021-04-07" version="1">MSFWEYLNTRHQQLLTDAFQHVSAVFQCMVIATVLGVVIGVVSYRSGWGGSLAITSTATILTIPSLAAIGLLIPLVGLGVAPTVITLTLYGLLPIVRNSIVGLRGVDPALVDAATGIGMSRVARLCRVELPLAWPPILTGIRVATQMLMGIAAIAAYASGPGLGNEIFRGIASLGSANAINQVLAGTLGIVVLALLFDAAYVLLGRLTIPRGIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAV7</accession>
    <name>A0A7K2ZAV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000418">
        <property type="protein sequence ID" value="MYW29442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dak1_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="15225" checksum="DC3AC4B62CEAA60F" modified="2021-04-07" version="1">EGVRVALVPTRAAVQGIAALAVHEPDRGFDEDVVAMTAAAGATRYAELAVAERQPWTMAGICQAGDILGLIDGDVAVIGADVPATARTVLDRMLAAGGELVTLVLGEDVPDAMADALEEHVREGYLAVDTVVYRGGHQRAPLLIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAY0</accession>
    <name>A0A7K2ZAY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000415">
        <property type="protein sequence ID" value="MYW29435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="2">
        <location>
            <begin position="336"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="425" mass="44819" checksum="D0842948E79A8F2A" modified="2021-04-07" version="1">PGQRAPAPDYRTEQFSFIEEPDEDSEDVIDWLKFTESRSERREEARRKGRNRMIALIVVAVLVVVGGVGYLWSADMLPGLSGKEEKKSVAVGAQQRDVIVVHLHNTKKGGTSTALLVDNATTKQGTTVLLPNTLAVAGDDGATTTLGKSVDDDGRTGTRESIETLLGTKISGTWRLDTPYLEILVEQVGNIEMDTDIDVPDAKKGAAPLVRKGEAQTLSGPMAVAYATYLAPGEAEAKQLTRFGDVMRAVLRKISEDPKAATVTVETLAQVLDPSLPEKDLGASLAKLASRAKVGDYKTAMLPVQDDGTLTDTATRSVVKDILGGTVKTPEEGAPLRVAVRNATGDTGAGESARITLVNGGYAFVDSGKAETAAESVVLYRGAGDKEKATEVAKTLGLPAGAVKKGEPAANADVSAVLGQDYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBK9</accession>
    <name>A0A7K2ZBK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="355" mass="38613" checksum="F18F52F71D4F065E" modified="2021-04-07" version="1">MRRYAEQRLLDVASSASLKVYISEWENGRRAITDRYATLLRPLLGVTDAELRCEVAELQPAAGGYDELLSRIDSSSSLSEGMVGSFLDQTELLRTMDRQMGAAGLVDQMNGHLAAMEDALTFAVLPGARRPIAAALAGASTLAAWQALDAGAVERAWRRYELAKKAAQDAGSPLYLAHAMGEQAYVLADAGRPLLAIELVRDAQRTQTERQSPRLRAWLAAAEAELCASAGVDMASEARAALERAEALLPDDGEVRDPDMLSIFLNAGHLTRWRGNVLAKLGDESAMDELYNSLNSADPSFVRASAGVHCDLMQAHLARGELDQARSHLQRARLAANRTGSVRYRQRVELLTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBP7</accession>
    <name>A0A7K2ZBP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">GT040_10980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="WWKE01000498">
        <property type="protein sequence ID" value="MYW29791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW29791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="35807" checksum="ACD49B8A0EEEC716" modified="2021-04-07" version="1">MKVGIVGATGQVGTVMLRILAERDFPVDELRLFASARSAGSTIDFKGSGVTVEDASTADYTGLDIVLFSAGGATSKALAEKVAGQGAVVIDNSSAWRKDPEVPLVVSEVNPHAARVRPKGIIANPNCTTMAAMPVLRPLHAEAGLEALTVATYQAVSGSGVAGVAELHGQASKVVAEAEKLAHDGEAVDFPEPAVYKRPIAFNVLPLAGSIVDDGSFETDEEQKLRNESRKILEIPELKVSGTCVRVPVFSGHSLQINARFARPIGVERAVELLKDAEGVELSEIPTPLQAAGKDASFVGRIRVDETVDNGLALFVSNDNLRKGAALNAVQIAELVAAELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC37</accession>
    <name>A0A7K2ZC37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000519">
        <property type="protein sequence ID" value="MYW29872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7610" checksum="862D1409C01C4413" modified="2021-04-07" version="1" fragment="single">MEHVPPPAEELALLDRELAQLDARRAHLLTRRAWLVSALQPQAAQAPNAPRRHTPPVGHGWAPGQPWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC79</accession>
    <name>A0A7K2ZC79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000520">
        <property type="protein sequence ID" value="MYW29875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="264" mass="28070" checksum="6520EBD0C7B23840" modified="2021-04-07" version="1" fragment="single">MGSPVRVLAEATPDTRDRYVDLLRVASLAAVVLGHWMMAAVTPDGVGNLLAVVPALQPLTWLLQVMPVFFFVGGFAHALSYRSLLRKRPEGSTDSVYAAFLRARLQRLLRPTMVFVLVWGVAALLIQLLGGGGGLTGVTLRLVTQPLWFIGIYLAMVAFTPPLLRLHERYGWGAFAGLAGAAAAVDVLRFAAGVPYVEFLNFAFVWLAVHQLGFLRADGRLGAGPALSALRRPALLAGGGLITAVALVAAGPYPLSMVGMPGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCK4</accession>
    <name>A0A7K2ZCK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phospho-sugar mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_12350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000568">
        <property type="protein sequence ID" value="MYW30052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="89"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="190"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="311"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW30052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="415" mass="43128" checksum="B7C21FB776AAA64B" modified="2021-04-07" version="1" fragment="single">LAYAIRHLGAVAGVEVTASHNPPRDNGYKVYLGDGSQIVPPADGEIAAAIDAVGPLGGVARPEDGWQTLGEEVLDAYLARTDAVLAPGSPRTARTVYTAMHGVGTSVLTAAFERAGFPAPVLVAEQAEPDPAFPTVAFPNPEEPGAMDLAFATARRAAPDLIIANDPDADRCAVAVPDTATEGGWRMLRGDEVGALLAAHLVERGVSGVFAESIVSSSLLGRIAGKAGLGYEETLTGFKWIARVDGLRYGYEEALGYCVDPEGVRDKDGITAALLVAELASVLKEQGRTLLDLLDDLALAHGLHATDQLSVRVEDLTVIADAMARLREQPPTSLAGLAVISAEDLSQGTASLPPTDGLRYQLEGARVIVRPSGTEPKLKCYLEVVVPVADAAGLPAARARGAELLAGIKRDLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD04</accession>
    <name>A0A7K2ZD04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3492 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000612">
        <property type="protein sequence ID" value="MYW30223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3492" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="473" mass="50268" checksum="07AD8944ABD675ED" modified="2021-04-07" version="1" fragment="single">MRIGLLTDGGYPYATGESRFWCDRLVRGLPQHEFDLFALSRSAHQEDQGWVRLPHHVSRVRTAPLWTPEDGTPRGSGERGLLARLVTGGGVSYGRRDRKRFAAHVEALATAVCATEDTGTAPADDGGLFTEGFYGLAELARERGGLHLALRSETTVRILEAASRARGAGRTVQSATVVDHLAFAAELERVLRPLSLDWYGPESLGAVDLCHAASGGAAAIPGLLAKRFFGVPLLVTEHGVQLRTHYLAAPDASFGAPVRALLARFHTLLAAEVYRQASLVTAGNTHVRRWQQRCGADPAQLRTVYPGMVAERFSAVGEDDDAGGPDTLVWVGRIEPAKDLIALLHAFAEVRRAEPDARLRIFGAPVVGDEATTYLAHCRALAAQLFPDEATGAHTEGVSPVTFEEIGGPEVPGLAEAYAAGGVIVLSSVVEGFPISLVESMFCGRATVSTDVGAVVEVIGGTGLVAPPRNPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD25</accession>
    <name>A0A7K2ZD25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_13210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000611">
        <property type="protein sequence ID" value="MYW30219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="21144" checksum="95EB135D5DD67C32" modified="2021-04-07" version="1">MADRGEDPGRTVLPATPSTAPATTPSAPPPPSGPASPTPPPARPLDAIDRDILRILQTDGRASIRSVAERVHVSRANAYARINRLVEDGVIRGFGARVDHERAGQGASAYITLKIVQNSWRTVREQLQALPGATHIALVSGDFDVLLLVHTPDNRALRELVLTRIQSIPEVLSTRTLLVFEETDLGPRPDRPAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD67</accession>
    <name>A0A7K2ZD67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000650">
        <property type="protein sequence ID" value="MYW30294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="112" mass="11350" checksum="EF1243D8F3B58D89" modified="2021-04-07" version="1" fragment="single">MPGGPGWWTFCAAASLALAAFTSLGPHRVWGAAGALGYAAAAVLAARQRPARTVGAAAITGAVVLPLVVLLAVDRAQLEVEVVARSAALLLADGTPYAAQPLIPEDFNPYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD76</accession>
    <name>A0A7K2ZD76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_13240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000612">
        <property type="protein sequence ID" value="MYW30225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="110"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="35150" checksum="8D8B750627FF3F80" modified="2021-04-07" version="1">MTGFLIRRLGGAVLVLFALTAILYGIFYVAPGDVAQIVCGPRCSPAQVAQVTEQLRLNDPLYVRYGHFLQGIVAGRDFSTGTGVEHCSAPCLGVSYQSDQQVTQLILAKLPVTGSLVIGAFAGWLLLGVGTGVLSAWRRGRLTERVLTWLTLAGSATPVFVIGLLLIIVFCSTLQWLPAPSYVPFAEDPEQWAWGLLLPWVSLALIESAKYARLTRSAMLETLAEDHVRTFRAYGVGERAIIGRHALRGAVAPVIALSALDFGTMFGGAVLTESLFGIPGIGRELVNAVKVVDLPVVVGMVLVTGFFVVLANAAADLLYALADRRVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDC8</accession>
    <name>A0A7K2ZDC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-IB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000652">
        <property type="protein sequence ID" value="MYW30318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="307" mass="32996" checksum="86CB8DAC85FCFE56" modified="2021-04-07" version="1" fragment="single">MAALGWLTPRRRSATARSVLAGEAAAEAARKTSAEDESALLTGAPDQASGQAPEEPAFPVAGDDRAAAFFDLDNTVMQGAAIFHFGRGLYKRKFFERRELTRFAWQQAWFRLAGVEDPEHMQDARDSALSIVKGHRVSELMSIGEEIYDEYMADRIWPGTRALAQAHLDAGQRVWLVTAAPVETATIIARRLGLTGALGTVAESVDGVYTGRLVGEPLHGPAKAEAVRALAAAEGLDLERCAAYSDSHNDIPMLSLVGHPYAINPDTKLRKHARALDWRLRDYRTGRKAAKVGIPAAAGVGALAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDN0</accession>
    <name>A0A7K2ZDN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="8" type="ORF">GT040_14520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000676">
        <property type="protein sequence ID" value="MYW30463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="6">
        <location>
            <begin position="5"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="7">
        <location>
            <begin position="262"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="547" mass="57595" checksum="C4FE85B47D7EDA31" modified="2021-04-07" version="1">MSGGLLVAGTTSDAGKSVVTAGICRWLVRRGVKVAPFKAQNMSLNSFVTREGAEIGRAQAMQAQAARVEPTALMNPVLLKPGSDRSSQVVLMGKPVGEMSARGYHGGRQEALLGTVTGCLEELRSTYDAVICEGAGSPAEINLRRTDIVNMGIARAAKFPVLVVGDIDRGGVFASFFGTTALLSAEDQALVAGYLVNKFRGDVSLLEPGLDMLYGLTGRRTYGVLPFTHGLGIDEEDGLRVSLRGAVRESVVAPPHGEEVLRVAVCAVPLMSNFTDVDALAAEPGVVVRFVDRPDELADADLVVVPGTRGTVKALAWLRERGLADALARRAAEGRPVLGICGGFQVLGERIEDEVESRAGVVDGLGVLPVRVRFERAKTLARPVGSALGEPVEGYEIHHGIADVRGGEPFLDGCRVGAVWGTHWHGSLESDGFRRRFLEEVARAAGRRFVPAPDTSFGVLREEQLDRLGDLVEEHADTDALWRLIEGGAPAGLPFVPPGAPPLGAGASSESRGAAPDPAPQSPEGLENPGSAGIGQEAEQHANKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDV0</accession>
    <name>A0A7K2ZDV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000695">
        <property type="protein sequence ID" value="MYW30502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="58" mass="5870" checksum="5955030FFEBCF2C4" modified="2021-04-07" version="1">TERGAEIATVALAWLAARPTVAAPIASARTVEQLPALLAVADLELTEAELAALTEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE93</accession>
    <name>A0A7K2ZE93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03618 family F420-dependent PPOX class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000727">
        <property type="protein sequence ID" value="MYW30652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="12796" checksum="2CD1D31ABBD1C0E3" modified="2021-04-07" version="1" fragment="single">MTTTPFNPHALLAKSSLGTLATVKSDGRPQLSPVQPFFDQEAGVIYVSTSQGTAKTANLRRDARATLMVLSSDGWEWATAEGVATLTGPGEDPGGPEVEALVDYYRKAAGEHPDWDEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEQ7</accession>
    <name>A0A7K2ZEQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000761">
        <property type="protein sequence ID" value="MYW30789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="457" mass="48570" checksum="560535276FBBAD02" modified="2021-04-07" version="1">MTPHAPHAPYADPAAGAAVKAADRAHVFHSWSAQGLIDPLAVAGAEGAYFWDYDGNRYLDFTSGLVYTNIGYQHPTVIAAIQEQAGKLATFAPAFAIEARSEAARLIAERTPGDLDKIFFTNGGAEAVENAIRMARLHTGRTKVLSAYRSYHGATSTAINLTGDPRRWPSDNGSAGVVRFWAPFLYRSPFYSETEAEECARALQHLEDTLAFEGPSTIAAIILETIPGTAGIMTPPPGYLAGVREICDRYGIVFVLDEVMAGFGRTGAWFAADHFDVVPDLLTFAKGVNSGYVPLGGVAISAEIAATFETRPYPGGLTYSGHPLACAAAVATIGVMEDEKVVENAARIGETVLGPGLRELAERHPSVGEVRGLGAFWALELVRDRETREPLVPYNASGEAAAPMAAFGAAAKKQGLWPFINMNRTHAVPACNVTEAEAKEGLAALDIALAVADEHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZES8</accession>
    <name>A0A7K2ZES8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000767">
        <property type="protein sequence ID" value="MYW30832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="16723" checksum="2ACFBDC945FAF3A2" modified="2021-04-07" version="1">MNARVNVIGSPTTATILKHLTAAGRAVSEAGLSTTTQELVKIRASQINGCGFCTDMHTKEAEAAGETSLRLNLIAAWREATVFTDAERAALELTEQGTRIADAAGGVPDEVWARAAEHYDEDQLLALVSLIALINAFNRLNVIVQQPAGDYQVGQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEU7</accession>
    <name>A0A7K2ZEU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_16705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000772">
        <property type="protein sequence ID" value="MYW30870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="3">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="268"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="548" mass="56270" checksum="292D00C85C43322C" modified="2021-04-07" version="1">MRSGAKIAVVGGVFVLAAGGIGYGAYSMLGGDGGGDSGKVASRNATPEVKTGPLSPEEITEASKSFFDAWAAGDAATAALLTNNEAEAEPVLASYGEDAHIGKMKITPGQAVGTTVPYTVKATVSYGGKAKPLSYASELTVVRGLTTGKALVDWEPTVVHPRLTDGATLITGESSTAAIEAVDRNGTVLTKEKYPSLGTILDTLRQKYGESAGGSPGVETWIDPAEDGQADINLLTLAKGKPGKVRTTLDAGVQTAAEQAVKRFAESSVAAVQPSTGAILAIANNRKDGYNAAMSGQLAPGSTMKIITAAMIIQNGLGSMNSAVECPATVQWEGVTFHNLKDFSIRNATLREAFAQSCNSTFIKPIKPLGGRAGTALGQEARDYFGLGQDNWQTGVPSFDGRIPESSGTETAASYIGQGKVLMSPLNMASVTATVKNGGFKQPYLIARALDDRPFAGARPLPAGVAEQLRQMMRYTATSPTGTGTESMATVGGDKGAKTGSAEVYGQTSNSWFTGFSNDLAAAAVVQSGGHGSDAAGPLVAEVLRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEV1</accession>
    <name>A0A7K2ZEV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4129 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_16765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000776">
        <property type="protein sequence ID" value="MYW30881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029630866" evidence="3">
        <location>
            <begin position="21"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="4">
        <location>
            <begin position="484"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="743" mass="77168" checksum="258616A10A8AFB95" modified="2021-04-07" version="1" fragment="single">MSGRARLALCAFAATLMASGALLPLVEGAGWLVQAALLLGVQGGVGALARRVPLARSLTIASQTLVTLLLLTVVFARDQAVFGVLPGPQAVVRLGELLVAGGEDIGTYAIPAPMTDGIRLMVVGGVVLIGLAVDALAVTFRSAAPAGLPLLALYSVAAGLGDGGTGWLWFLLAACGYLLLLLAEGRDRLSQWGRVFGGANRSPGGLSDGPSGRGGGASAPVRTGRRIGVLALGIALVVPLALPALDSGLLSGRGGGNGKGSGGGTITAVNPLVSLKDNLNQPDNREVMTYRTNAEDPRDLYLRIISLDEFNGSEWRSSTRRLTDVPDRLPQPTGLGRDVSVTEIRTNISSSPSYRQNYLPLPYPASEVAIEGRWRYEPEGRTLIGDDGQDTGGAQYEVSSLVVEPTAAQLAAAGPPPQKLRSEYTQVPDSLPNVVAEEAEKITEGSANAYERAVKLQSWFASEGGFTYNTSVSSGTGSSAIARFLRDKEGFCIHFSFTMAAMARTLDIPARVAVGFTPGTLQADGSTSVGLRDAHAWPELYFEGVGWTRFEPTPSRGATPAYTLPETPTGGSSAPAQPSADASTAPSAVPSASESCSPQMRRQGECGLSAAPGPTSPTDEGTPAGTVALVVLGALLVLLLPLLPLLWRIRVRNRRLGSGGRTSADAAARVLAAWQEITDCAWDYGIAPDESLTPRKAAARIVRLGGLGTMAAEAVHRIAGAVEQVLYAPEPRLAAGLTEDALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEY9</accession>
    <name>A0A7K2ZEY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">M48 family metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_16980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000803">
        <property type="protein sequence ID" value="MYW30924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="7">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="81" mass="8959" checksum="E881EEC5076A8DC1" modified="2021-04-07" version="1" fragment="single">KQRRAELLVRSPLLPGEEPGADRLVVLEGERPDAWWLPGSAPQLVITTAALGRLKGRQLDAVLAHEQGHAQARHDWLLHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF31</accession>
    <name>A0A7K2ZF31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000808">
        <property type="protein sequence ID" value="MYW30967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="8"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="330" mass="34412" checksum="53679B6D3A689CA2" modified="2021-04-07" version="1">MSAYFETATGDLAAEALRSFADVHGELVSAHPGFGFLTARDTSETRAVGLLSGGGSGHEPLHCGYVGRGMLDAAVPGRVFASPHNRQVYEASLAVARPGGVLHLVKNYTGDRINFGIAAERLAHQGIPCARVLIDDDLASDAADIAAGRRGTGGTVLVEKILGAAADTGMGLAELRSLGERLVARCRSLAIATSAHTSPATGEPAFTLDAGRLEYGVGIHGERASSTTPRRPLPDLVERMTTELLGALPSDTPVISLVNGLGATTLLELYAAHGQLVHQLRGAGVPLARSLVGNYITSLDMHGFSITLMAVDPQTLSLYDAPVHTPALRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG68</accession>
    <name>A0A7K2ZG68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000896">
        <property type="protein sequence ID" value="MYW31332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10134" checksum="0E90E0FC1F29F72C" modified="2021-04-07" version="1" fragment="single">MADTAMSGSGTTADGDPPLQTAVWRLRSRACWTDAAALLEPHATRDPAAAIQRTALLTERCLYTGEGWTDAEDALRGAEALARTDDERGGAACERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGN7</accession>
    <name>A0A7K2ZGN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000927">
        <property type="protein sequence ID" value="MYW31478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="145" mass="15766" checksum="87734637D3254165" modified="2021-04-07" version="1">MAVFRIERFSPLPAAEAWRRVTDWERHAERVPLTAISVAGGPPTRVGTVFTARTGVGPLAFDDPMEVVRWTPPAGGRAGICLLEKRGSVVLGRASIDVLPTHSGSHVVWVEELRVRLVPRWGDPLLASAGRRLFGGVLDELLDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH30</accession>
    <name>A0A7K2ZH30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000974">
        <property type="protein sequence ID" value="MYW31625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019733">
        <property type="entry name" value="Uncharacterised_YhfT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10797">
        <property type="entry name" value="YhfT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="430" mass="44823" checksum="ED178F4F6FE77C29" modified="2021-04-07" version="1" fragment="single">MSTTLAAGSGFDFTLAQQLTVIALCALTAFIAHMALAVFNDGVRPFLLDFIQGRTTRSATTAVSFGLSAGFIFGLGAPMALSTGVLNPWLLFLPTDILGLLSPKKWLAPILGGAWGAVVVFGLNGANNIAHDLPVDFLTAMQQMSTPILFLFTLFPVLAITKQFGRLRGAVAGVVEVALVVLTMKLWPNMFAGALAMAVGVLMLIGLAVAKDLRQRRADRAAGVVEEVPADDPMASLFSASAARLRRYLPLFMVLGAGVCVLAQMHVFGGGEATSFLIAKGQYAEAAQVDFYRVFGFIPLIATTALASGAYGIAGFTLVYPIGYLMPNPFLAAVVGALVFAVEVLALSWIGKVLGKLPSVRDSSEHLRSAIGDTLQLAILFGSLMAANAMGGGLGILIVGGLYLFNEAMGRPVVKMAAAPAAVIVGGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHV1</accession>
    <name>A0A7K2ZHV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_22105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001042">
        <property type="protein sequence ID" value="MYW31895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="30748" checksum="1699213A51BFAC90" modified="2021-04-07" version="1">MVPFFALFTAVTVLPMFYAAWMSLFREESSGLGFGGTERVFAGFGNFTEALGNEAFLRSFGHIAFYCVLYIPAMVGGALILALLVDSAMARARRFFQIAYFLPHAVPGLIASLIWLYLYTPGLSPVTDVLDALGANWNFFGQDEAIYSVVNISAWQWTGYNMIIFYAGLQAVPREVLEAATVDGSGALRTALQVKVPMIRPTVVLTLLFTCVGAIQLFDAPKLVQLRANTMGEDWSPTMFIYTAAFKGHDYGLAAASSLILALVAGLLSFVVTKLGNRWKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI75</accession>
    <name>A0A7K2ZI75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001072">
        <property type="protein sequence ID" value="MYW32051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="10570" checksum="B777460FCFE0FF9F" modified="2021-04-07" version="1">MMFDGKGRAMRLLPWTNDFGAPCWLSTANPDSRISRMADELEVAMIASAEEVLAEAGGLLAESVVGEQELRFAGARLAESLGDTLRIAASRGGRLESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI89</accession>
    <name>A0A7K2ZI89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001072">
        <property type="protein sequence ID" value="MYW32048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="108"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="30865" checksum="568D6E6661972C2E" modified="2021-04-07" version="1">MSASPPSSVVEARKALAHRLINIRKDAGLTGGELSLRCGWNAAKTSRIQSAKKAPSESDIRAWCRVCGAEEQIPDLIAAARAVESMYTEWRQMERTGLRAAQESVAGLYERTGLFRVYSSRVLPGMVQTAAYTAAVLRSIQRERVAVDDVDDAVQTRTERQDALFSGRHRFGLLVEEYVLRAAVCDRHVMAAQLDHLIAIGSKPFVSLGIIPLGVGRAHLPAEDFYMFDEVEVAVELTSGYLRITQPREIAAYARAFTDMANTAVHGAHARTLIQAAINALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI96</accession>
    <name>A0A7K2ZI96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cobT</name>
        <name evidence="13" type="ORF">GT040_23110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001080">
        <property type="protein sequence ID" value="MYW32083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02145">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nitroreductase" evidence="12">
        <location>
            <begin position="303"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW32083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="799" mass="83980" checksum="2DF024EFB2D6C2CB" modified="2021-04-07" version="1" fragment="single">MEPETAVEAVVEAEAPVEPVAVPEAAEPAAPVEAEQPVAPETVAPPEQVVPQPVEAEVVAPAEPVEVVQPEAVVPAEPEQPVQVEQPEVVAPVQVEQPVQAEAVVEPEPAQVPEPVVVQPEPVEQVALAETVVPEPVVAEQPEAPAEAVALTELPAEAAVETPVDAPAEVPAAPAGVPAESAAQPVPEPRAPVQQQELAADPVQPVEAAEPAPPAEEAVEPAEVQPEPEPDRTAPQPTPEPATQAEPVTDAEDGTGPEVIETPELDEQPVEQPTAEAAAPQEPFTAPAPGYDDAEREAVLRVMRERRDIRNGFRSDPIPHEVLLRVLEAAHTAPSVGHSQPWDFVVIRSAETRRSMHELAQRQREAYAKSLPKGRAKQFKELKIEAILDTPVNIVVTADPTRGGRHTLGRHTQPQMAPYSSALAVENLWLAARAEGLGVGWVSFFDEREMVRALGLPEHLEVVAYLCVGYVDEFPEEPELLQAGWSKRRPLSWVVHEETYGRRALPGEEPHDLLQETISAIRPLDAKALGEAWERQKRMTKPAGALGMLEIISAQLSGLSRMCPPPIPEPAAVAIFAGDHGVHAQGVTAWPQEVTAQMVANFLGGGAVCNAFAAQVGAEVCVVDVGVATDLPATPGLLPRKVRKGTSDFTTGPALTREEVLAAIEVGIETARDLVAAGNKALLTGEMGIANTTASAALICVYTGADASEVTGRGTGINDEMHARKVDVVRRALDLHQPDASDPIGVLAAVGGLEHAAMAGFLLGGASLRTPVILDGVSAGAAALVARAIAPEALAACIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIF8</accession>
    <name>A0A7K2ZIF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_23225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001090">
        <property type="protein sequence ID" value="MYW32105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="367"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="453" mass="49620" checksum="5AD687242155E43C" modified="2021-04-07" version="1">MTRPVRVAIVGAGPAGIYAADALLKSEVCQDPGVSIDLFERMPAPFGLIRYGVAPDHPRIKGIVKALHQVLDKPQIRLFGNVSYPNDIGLDDLRSFYDAVIFSTGAEADRALDITGIELDGSYGAAEFVSWYDGHPEVPRTWPLTAEKVAVLGVGNVALDVARVLAKTADELLPTEIPDNVYQGLKENKALEVHVFGRRGPAQAKFSPMELRELDHSPNIEVIVNPEDIEYDEGSIATRRENKQANMVAQTLENWAIRDVGDRPHKLFLHFFESPVEILGEDGKVVALRTERTELDGTGNVRGTGKFTDWDMQSVYRAVGYYSEELPKLPFDVASGTVPHEAGRVIAGDEHMASVYVTGWIKRGPIGLIGHTKGDANETVACLLEDRAAGRLPEPATPAPEAVEAFLESRDVRYTTWEGWHKLDAHEQALGAAQGRERIKVVEREGMLDASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIJ8</accession>
    <name>A0A7K2ZIJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="21584" checksum="D2B19FCC4DA7D3D9" modified="2021-04-07" version="1">MSEPDKHEPDPAIPPLDTIDDSQRIPPPRRPAPPRPRPIKAADDIPPGAIAAFGVVALVALLLILKWGIPKGIDWYHHQDWAWFTQWTATVADPVHAYLSAHTVGLPLTATSAFVIWQGVGIVSLALSWITGAVGARLTWTAHGACSVFMVWDAAPAAGRPVAAALTVLAWTIGSLFALRGLSLRPLIHLHNHNHNHPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIN6</accession>
    <name>A0A7K2ZIN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070204304.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001107.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="8279" checksum="25B0C3E96420B6C3" modified="2021-04-07" version="1">MTTTDPLLTVEQAAHRLGTGVRFIRRLVQERRIRYVKLGKPVRIPESAIAAYIEERTVPTLRDERSRYGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ15</accession>
    <name>A0A7K2ZJ15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_24355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001145">
        <property type="protein sequence ID" value="MYW32315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="20392" checksum="41260F961032FF46" modified="2021-04-07" version="1" fragment="single">FNQLRKLKAQYPHIKVLWSFGGWTWSGGFGQAVQNPTAFAQSCYDLVEDPRWADVFDGIDLDWEYPNACGLTCDSSGPASIKNMMQAMRAKFGPNNLLTAAITADGSNGGKLDAADYGGAAQYIDWYDVMTYDYFGSWAAQGPTAPHSPLTSYPGIPAQGFNSADAIAKLRAKGVPASKLLLGIGFYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJE1</accession>
    <name>A0A7K2ZJE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001174">
        <property type="protein sequence ID" value="MYW32451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029710497" evidence="2">
        <location>
            <begin position="30"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="18504" checksum="E26CF2EDBC661446" modified="2021-04-07" version="1">MVAGLTAAAVVAVAVLAYQASANAPDSVASSSSATPKASASAPAQPTAKPKPTKDALAVPADSDTGERVVYALKDRRVWLVDGDEKALRTFTVMPSPVSPPPGVYQVSSRSGTVQGSDGIPIEHVVRFANVGEVAVGFSAAQDGSMQAPDPQSKTGGVRMKRADGNAMWTFATVGAKVVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK62</accession>
    <name>A0A7K2ZK62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">GT040_26545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003956441.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001248.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZK62"/>
    <dbReference type="GeneID" id="63982148"/>
    <dbReference type="GeneID" id="66955264"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="37" mass="4389" checksum="349DC4355BFEF0C8" modified="2021-04-07" version="1">MKVKPSVKKICDKCKVIRRHGRVMVICDNLRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK68</accession>
    <name>A0A7K2ZK68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">GT040_26555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="278" mass="29664" checksum="7C2E41D68AB12E39" modified="2021-04-07" version="1">MVQIKTPEQIAKMREAGLVVAAIHAATREAAVPGATTHDLDQVARKVIADHGARSNFLGYGGFPATICTSVNEVVVHGIPDEKTVLKDGDIISIDAGAIVDGWHGDAAYTAFVGTGHAPELVELSRVTEESMWAGIAAMKVNNRLVDISKAIESYIRRQPRPATGKYGIIEDFGGHGIGTEMHMDPHLLNYVSRKRGKGIKLVPGVCLAIEPMVSLGTARTETLSDDWTVITTDGTWSSHWEHSIALTERGPLVLTAPDCGKAKLAEYGVEAAPDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKN5</accession>
    <name>A0A7K2ZKN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001286">
        <property type="protein sequence ID" value="MYW32912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="16823" checksum="6F5E71E1ADD02A3D" modified="2021-04-07" version="1" fragment="single">GHRPDGTATGPGTAAGEAADVWDSYAEHPVPERLGARVRAVLEEHGALETLLGTVPVPEIAAALRRTGNDELVYLLPTRNSPVSGGALRVGSGGGVRWMPLGGLADTSSLDAYTGALELLLSAPRADAVEDAWRARLEEVCDWAGRAVVEHLARDAAGAGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKS9</accession>
    <name>A0A7K2ZKS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsB</name>
        <name evidence="7" type="ORF">GT040_27750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001298">
        <property type="protein sequence ID" value="MYW32964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="306" mass="33518" checksum="E36BB686483DF318" modified="2021-04-07" version="1">MAVVTMRELLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLLQSLSYIDRAYEFVKETVAHGGSIMFVGTKKQAQEAIAEQATRVGMPYVNQRWLGGMLTNFSTVYKRLQRLKELELIDFEDVAASGLTKKELLVLSREKAKLEKTLGGIREMQKVPSAVWIVDTKKEHIAVGEARKLHIPVVAILDTNCDPDEVDYKIPGNDDAIRSVTLLTRVIADAVAEGLIARSGAATGDSKPGEKAAGEPLAEWERDLLEGDKKDETAAAAEVQSSAETEKVADAEKPAEAVAEAAAEAPAADADAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL77</accession>
    <name>A0A7K2ZL77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsE</name>
        <name evidence="8" type="ORF">GT040_27930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001301">
        <property type="protein sequence ID" value="MYW32999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512316.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001301.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="25694" checksum="88700EAE3F4BE1F3" modified="2021-04-07" version="1">MIRFDNVSKTYPKQTRPALRDVSLDIEKGEFVFLVGSSGSGKSTFMRLILREERASTGMVHVLGKDLARLSNWKVPQMRRQLGTVFQDFRLLPNKTVAQNVAFAQEVIGKPRGEIRKAVPQVLDLVGLGGKEERMPGELSGGEQQRVAIARAFVNRPMLLIADEPTGNLDPQTSVGIMKLLDRINRTGTTVIMATHDQNIVDQMRKRVIELEQGRLVRDQARGVYGYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLI6</accession>
    <name>A0A7K2ZLI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001353">
        <property type="protein sequence ID" value="MYW33215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="410" mass="43692" checksum="091C8E8820C239E1" modified="2021-04-07" version="1">MGTAGIPSQQEITGDSSPSALLWNVDATILLVEDDAGDALLVEEMLTDSELDSALTWRKTLAEARAFLRTCATPVCVLLDLHLPDVHGLDAVRQILESDSEAAIVVLTGLDESGTGLRAVAGGAQDYLVKGRLDPEMLSRAIRYALQRKEVERAAAALRSNQLIAQENARLERGLLPVPLLRDDRFQARARYEPGRVHGLLSGDFYDVVQTADGAVHAVIGDVSGHGAAEAALGVCLRVAWRTAVLCGTSHLEQIELLEEILVAERSDSHVFATMTSLTFAPDGRSVQIVRAGHPGLLLRRGEEVRWVEPEGGMALGLLPGMGRWPTVDLPLIPGDGLVLFTDGLFEGRNGPDSRLGEEGLLEMARAYGPLPGRRFVDALVAGAAEGAAPYGGLADDVAVLHLGWGSELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLJ0</accession>
    <name>A0A7K2ZLJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2813 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001352">
        <property type="protein sequence ID" value="MYW33206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022602">
        <property type="entry name" value="DUF2813"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11398">
        <property type="entry name" value="DUF2813"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="628" mass="69617" checksum="E3E4A0E75CC7D262" modified="2021-04-07" version="1">MYLNKFSVIGFRSLQDVRDIPVSKPTILAGHNDGGKSALLDALGLLVGSHNMLDDDRSYVRSETPGEEDTFERCMETLVIGDFALDDWEQHEFDLPPSVQLRRRVDAGLNLSLEFWGPVPEDSRLTDLAQYLLPDLKALAAELGVKPDSPRPRKADFENCLRAHGRQHSKGEGWSSAPSGLQRRMPRLLIFDGKAARPDDAVKTALNGKFQAHMGDVSLQGKLQAVEDEVKELLRIDAKSLCDHIKERCPDLTEVFVDPDVSFQRGFNGAPLRISRIKGATVGLDRSGLGSNRRVSLAVWEWTSELLAAEETKADGPTPPVEEGSEVEPPAVQTIVVYDEPDTHLDYHHQRKVMGLIRHQAAIPHVSVVVATHSMNLIDGVDISDVVHLKLEDLRTIAERIGAKESGEVIDVHLGRIAAALGLRNSVLLHERCFLAVEGDTEQRAFPLLFRLCEGLSLQAAGIALWACFNNEGALHLARYLVKQKRTFRLVVDADSRTLPKSIFKDHKLREHFGPDVADYVTFIGETDESGADSVAELEALFSDDLWATVANEVWPKNDGTWLSSDFAELRKTKKFSAAVEEMLQTGSDAGPGGKPDMMYRFSMALTDAQQVPEQLRQVFSQVRKLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM38</accession>
    <name>A0A7K2ZM38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4129 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_30185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001392">
        <property type="protein sequence ID" value="MYW33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="141"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="23898" checksum="4A93D07B1718EE53" modified="2021-04-07" version="1">MSGAGGTTAAQQATGAGDIPVDTPRVPAREAAESELSKPMYHENDPSILQRGLNHFWDWVAGVFDAAAGAAPGGPAGLAVLALILIGLAAALWWRLGTPQRSSRTPDALFESDGPRSAAQHRAAADAHAAALRWTEAVQERMRAIVRSLEERALLDPRPGRTADEAATEAGRALPGHATRLRSAARDFDDVTYGGRAAGQPTYLALRALDTELDEAKPVLPGASRGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM50</accession>
    <name>A0A7K2ZM50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GT040_29975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="WWKE01001387">
        <property type="protein sequence ID" value="MYW33380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="299"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="424"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="538"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="855"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="790"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW33380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="903" mass="98283" checksum="3A827D00BEB82C22" modified="2021-04-07" version="1">MSENKDPQKFVYDFTEGNKDLKDLLGGKGANLAEMTNLGLPVPPGFTITTEACKVYLESGQAPKALRDEVSAHLTALEERMAKKLGQADDPLLVSVRSGAKFSMPGMMDTVLNIGLSDASVAGLATQSGDERFAWDSYRRLIQMFGKTVLGVDGDLFEEALEDAKAAKKVTVDTDLAAADLKKLVKQFKKIVQDQAGREFPQDAREQMDLAINAVFDSWNTDRAKLYRRQERIPGDLGTAVNVCSMVFGNLGPDSGTGVAFTRDPASGHQGVYGDYLQNAQGEDVVAGIRNTVPLADLESIDKKSYDQLMQIMETLENHYKDLCDIEFTIERGQLWMLQTRVGKRTAGAAFRIATQLVDQGLIDEAEALQRVNGAQLAQLMFPRFDIEARTELLGRGIAASPGAAVGKAVFDSYTAIKWSRSGEKVILIRRETNPDDLEGMIAAEGILTSRGGKTSHAAVVARGMGKTCVCGAEDLEVDTKRRRMTVGGKVIEEGDLVSIDGSTGKVYLGEVPVVPSPVVEYFEGRMHAGADDADELVAAVHRIMAYADRVRRLRVRANADNAEDALRARRFGAQGIGLCRTEHMFLGERREMVEKLILADTDDERESALAALLPLQKADFIELFESMDGLPVTVRLLDPPLHEFLPDITELSVRVALAESRKDANENDLRLLQAVHKLHEQNPMLGLRGVRLGLVIPGLFAMQVRAIAEAAAQRKNAKGDPRPEIMIPLVGTVQELEIVREEADRVIAEVQAATGTDLKLTIGTMIELPRAALTAGQIAEAAQFFSFGTNDLTQTVWGFSRDDVEASFFTAYLEKGIFGVSPFETIDKDGVGALVRSAAEAGRATRPDLKLGVCGEHGGDPESVHFFHEVGLDYVSCSPFRIPVARLEAGRAAAQSRGSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM54</accession>
    <name>A0A7K2ZM54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GlsB/YeaQ/YmgE family stress response membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_30215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509688.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001394.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="88" mass="9026" checksum="E05F22EEADB1CB2A" modified="2021-04-07" version="1">MGIIAWILIGLFAGLIAKALTPGKDPGGCLITIVIGIVGGLLGGWLGKVIFGVDSIDGFFSLSTWIAAIVGSVIVLLLYRVVTGGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM85</accession>
    <name>A0A7K2ZM85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PPOX class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001397">
        <property type="protein sequence ID" value="MYW33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="34" mass="3933" checksum="C79B39478B5AE1F5" modified="2021-04-07" version="1">GEHPDWDEYREAMVSGRRVLITMTVDHVYGARVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMJ2</accession>
    <name>A0A7K2ZMJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_31045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001435">
        <property type="protein sequence ID" value="MYW33583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513862.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001435.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="3">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="25896" checksum="17B6FD09D24CFFA1" modified="2021-04-07" version="1">MSRRSGILEFAVLGLLRESPMHGYELRKRLNTSLGIFRAFSYGTLYPCLKTLVASGWLIEEPSGDEADATPASSLTGRRAKIVYRLTAEGKEHFEELLSHTGPDAWEDEHFAARFAFFGQTERDVRMRVLEGRRSRLEERLEKMRASLARTRERLDDYTLELQRHGMESVEREVRWLNELIESERSGRDQRRSSPEGSAQQDTSGETGGLPRHRGDTPPDPSDDTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMV2</accession>
    <name>A0A7K2ZMV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_31575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="50"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="482"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW33686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="741" mass="78591" checksum="461951D0744E06A5" modified="2021-04-07" version="1">MPESPTPAPPVPQAPGRRTLSPKSIAVWSLVGLVGAIGWATLALSRGEEVSAAWMLAAALGSYAIAYRFYSRFIANRVLKTDKNRATPAERLDNGVDFHPTDRRVLFGHHFAAIAGAGPLVGPVLAAQMGYLPGTIWLVVGVIFAGAVQDMVTLFFSTRRNGRSLGQMARDEIGPVGGIAALVAVFIIMIILLAVLALVIVNALAHSPWGVFSIGMTIPIALFMGVYLRILRPGKVSEVSLIGVALLLLAIVAGGWVAESSWADFFTLEPGTLVIWMIVYGFLASVLPVWLLLAPRDYLSTFMKVGTIALLALGVIVALPTLKMPAVTDFATSGSGPVFAGSMFPFVFITIACGALSGFHSLVSSGTTPKMVQKETQIRVIGYGAMLVESFVAIMAMIAACIIDPGLYFAINAPVGVIGDSVQSASQAVANFGFTISPDALAQAAKDVEETSLLSRTGGAPTFALGMAEIFSAVIGGTAMKAFWYHFAIMFEALFILTTVDAGTRVGRFMLQDMLGNAYKPFREVSWKPGVWFASAVVVGGWGYFLWVGVHDPLGGINQLFPLFGIANQLLAAVALAVCTTLLVKSGRLKWAWVTAVPLAWDVAVTLTASWQKIFSPDVKVGFFAQRDKYQAGIDAGEVLPPAKNMDDMQTVVTNSTVDGVLCALFALLIIVVLVDAGRVCFNAIRDPESVKLHETPYVESKLVAPASIFATKEEKAELVAAGVGPEGGIRKEPTGTGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMV8</accession>
    <name>A0A7K2ZMV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="264"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="36218" checksum="A0B82FCFF743F614" modified="2021-04-07" version="1">MFQVLGLDARTELVYRLVLEEPELRLDQIVARLGRSEQDVRDALDRLAELCLLDNRDDRSTAGDPPVFRALDPAASLPFLLSRREAELARQQRGLEVARDAVSALAAHGGRGVRRGFDVIKRLEGLDAVRERLTELAELARTECLSLLPGGAQAPDTLAASKPLDQQALERGVRIRSIYQDSFRNDPDTLRYVNWIGGLGAESRTLPTLPLIMVVVDAEVALVPLDPDDGRAGALELRSKGAVLVARLLFESLWTAATPLGARPPVDSDGLTPQEGELLSLLSQGHTDATAARRLGVSLRTVRRMNAELTTRMDARSRFQAGAEAARRGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMW0</accession>
    <name>A0A7K2ZMW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="215"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="325" mass="35579" checksum="D49146CA0D8E535D" modified="2021-04-07" version="1">MLKNVAVLLLDEVHPFELGVLCEVFGLDRSEDGLPVHDFAVVSAQGPVVQTHAGFTISTPYGLDRLEEADLVAVPASSHAPDREYPEEALQALRRAVERGARVLSVCSGAYVLGAAGLLDGRRCTTHWRHAAELARRYPKAIVEPDVLYVDEGAVITSAGTASGIDACLHLVRQEYGQDTANTIARRMVVPPHRDGGQAQYISRPLPRNACDTVGSTLAWMEHHLDQEMSVEQLAALAHMSPRTFARRFQQETGTTPYRWLLRQRVLLAQHLLETSDRTIDTIAGQTGFGTAATLRHQFVRTLGTTPNAYRRTFRGPAGVVSDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNB1</accession>
    <name>A0A7K2ZNB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nuoL</name>
        <name evidence="9" type="ORF">GT040_32445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001486">
        <property type="protein sequence ID" value="MYW33854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="135"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="631" mass="66902" checksum="78195129E7C41B0E" modified="2021-04-07" version="1">MENLIALLVAAPLLGAAVLLCGGRRLDKAGHWLGTVLAAASFVIGAVLFADMLGKGAEDRALHQHLFSWIPVEGFQADIAFQLDQLSMTFVLLITGVGTLIHIYSIGYMEHDERRRRFFGYLNLFLAAMLILVIADNYLLLYVGWEGVGLASYLLIGFWQHKPSAATAAKKAFLVNRVGDMGLSIAIMLMFTTFGTFAFGPVLEATGEASEGKLTAIGLMLLLAACGKSAQVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGAIFNGAPDAQLVVAIVGAVTLIFGAIVGCAKDDIKKALAGSTMSQIGYMILAAGLGPIGYAFAIMHLVTHGFFKAGLFLGAGSVMHGMNDEVDMRKYGGLRKYMPVTFVTFGLGYLAIIGFPGLSGFFSKDKIIEAAFAKGGTEGWIFGSVALLGAAITAFYMTRVMLMTFFGEKRWQPDAEGHEPHPHESPKSMTIPMIVLAVGSVFAGGFFAIGDRFVNWLEPVTGYEHGHSPLSVAAVTGATVVALVIGVAIAWGMYGRKAVPVVAPRGSLLTRAARRDLLQDDFNHVVLVRGGEHLTRSLVYVDHSLVDGVVNGTAASVGGLSGRLRKLQNGYARSYAVSMFGGAAIVIAATLLMRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP18</accession>
    <name>A0A7K2ZP18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="26431" checksum="4C1EC95E4DC6A674" modified="2021-04-07" version="1">MDTVQDAGVVVTGAGGGIGAALARRFAEQGARVVVNDLDLARIEPLAKEIGGTAVAGDASGIVEAARDALGGTVDVYCANAGLASPGDAFADEEVWAAAWDVNVMAHVRAARALLPQWLERGSGRFVTTASAAGLLTMIGAAPYSVTKHGAVAFAEWLSLTYRHRGIKVHAICPQGVRTDMLTAAGSAGELVLAPGAIEPAAVADALFEAMAADRFLVLPHPEVAGYYQARAADPDRWIGNMNRLQQKWEEVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP97</accession>
    <name>A0A7K2ZP97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_33670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515406.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001542.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="22280" checksum="3FFA33F204329C79" modified="2021-04-07" version="1">MAKATEQNGTPVPQRLLAAATRLFAERGYDRTSVQEIVEAAGVTKGALYHYFGSKEDLLQEVYARVLRLQQERLDAFADADAPVEQRLRDAAADVVVTTIDNLDDAAIFFRSMHHLSPEKNKQVRVERRRYHERFRALIEEGQRSGVFSTATPADLVVDYHFGSVHHLSTWYRPDGPLSREQVAGHLADLLLRALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPL8</accession>
    <name>A0A7K2ZPL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001590">
        <property type="protein sequence ID" value="MYW34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="34511" checksum="AC912FD7692AF501" modified="2021-04-07" version="1">MSSGNTGIQQIHDVGAKALGWLYEHREGFRLETDPSPEAGVLDRFKPLGELALIGKVIFREGVAGSQQSALAHKLLDHAWHELLDSGARLLEGQRREPLSPVPLEVYVPFRELGYRQPDLESAIRLNHRLASWAGLEVLPVRRLGLSAIERRFGVEPSVPETAALAHTWLARRPEPWTVEGHIGYDITHTVFHLTDWGERPADLPVDIAEYLELWLPAWLDDWLDLKRWDLLGELLVVDACLPSPTLDAAAWQGFAQAQQPDGAMPVVGEMPEGDEESVFDLVYHPTLVAAFASALAMSRALSDLSAEPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPM7</accession>
    <name>A0A7K2ZPM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001584">
        <property type="protein sequence ID" value="MYW34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="90" mass="10207" checksum="94D84163A74D2FFC" modified="2021-04-07" version="1">MPKTQLNVRVDEATAEAARQRALQRGMSVNRYIEELVKQDAGEVGHTFVEAAADFMKQYESVFAEEFGPEREGPRREGPLREGPQREGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPQ4</accession>
    <name>A0A7K2ZPQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001590">
        <property type="protein sequence ID" value="MYW34307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="354" mass="38021" checksum="B227275D06CDBCB3" modified="2021-04-07" version="1">MTTTATQGSRGGPESQAPRGHASPGAALAVLPHVLRTALAWTDAHRAEFALDDDVLDPRTQVNATLKPLGELAQLCSTVRAATAPGTPEHEVAGDLVTYAWEQVGAGDLLLELLRTEPFAAYPYEIYAAFAGYGLRHEGFEALARPLTATRAWAHTEQHANRQLGLINSERRVGVVTHTDAGGVLSRTWLGGLSEPWTFEGPSGYALTHTVFHLTDWGRMPDRVPEKTDAYLRTWLPAWADGCLESGQWDLTGELLAVGASLPGPPPLELLDAVWPVLADVQHTTGCVPETGVPVHEDAPTGVRGHDDAPDPYPFIDCYHSTLVTAFAAALSLRSLRTLTDGSGSRSGRERHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPX4</accession>
    <name>A0A7K2ZPX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2238 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001606">
        <property type="protein sequence ID" value="MYW34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014509">
        <property type="entry name" value="UCP020606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09997">
        <property type="entry name" value="DUF2238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020606">
        <property type="entry name" value="UCP020606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="224" mass="24391" checksum="09A8030547EA6CAD" modified="2021-04-07" version="1">MSAHPAPAPTPAMSLPSRRRLPALLAVGVSAALVASWFGAADPTTWLLETVWVMVGLPLAILLRHRFPLSGLLCGLLAAHALVLIVGGHYTYAEVPVGDWVRDWLGWDRNPYDRFGHLVQGFVPALLVRELLLRTSPLRGSRWLAPLTVCACLAFSAVFEMIEWLAAVTGGQAADAFLGTQGDVWDTQWDMFCALIGAVCALLLLSRVHDRSLIRLSRERSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPX8</accession>
    <name>A0A7K2ZPX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_35405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001622">
        <property type="protein sequence ID" value="MYW34424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15567" checksum="EE4EE18FB31DEB2C" modified="2021-04-07" version="1">MTTPLTARQRLSELHRYAAVSGEDFTHQNLASTRTNQLRFARCSFAGADLRHATLEGCWFKFCDFTGADLRGASLRGAVLAGCNLRDADLRDTDLTGARLSSVSTGIPRLGPTDITGARFEGTSLLNVQADAVVGWPPEPVRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPY5</accession>
    <name>A0A7K2ZPY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001621">
        <property type="protein sequence ID" value="MYW34413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029636898" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="57" mass="5820" checksum="D1C3FD022EF761C0" modified="2021-04-07" version="1" fragment="single">MRRSRIRRLACAAALALGAALLSPAVPSAAAADPYQVLVFSKTAGFRHDSIPAGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ13</accession>
    <name>A0A7K2ZQ13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flotillin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_35415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001622">
        <property type="protein sequence ID" value="MYW34425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="5">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="266"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="51313" checksum="C626C48A425CE63D" modified="2021-04-07" version="1">MSPVALAVIGIVVLLVLLGLVVITRYKVAGPSEAFIITGRRGKKSTDPVTGLVSVDNSGQKVVVGGGVFVVPFVQQKFTLDLSSRHIPIAVRGAVTLRGVKSNLEGVAIVKVGGGEEAIRAAAQRFLQQQDGIVGFTQEVLSGALRAIVGRMSVEDIIRDRAAFAGQVAEEAETSLSGQGLILDAFQIQDITTEGSYLEDLGRPEAARAKQEADIAEAIAKRASEQARLKAAEEIAIAERTYYLKQAEIKAETEAAAAKANAAGPLAEAARQQEVLQEQEKVAERQAALTDRELDTKVRKPADAARYQAEQEAEARRIAQVKEAEADAERSRLTGQGEKLHRSALADAVRIEGEAEAASIAAKGAAEAEAMQKKADAFAQYGDAAVLQMLVEVLPDVVAKASEPLSAIDKMTVISTDGASQLARTVTDNVSQGMELLSSTTGVDVAQLLQNLKSRTGAPADTSSPTPEKTPQDKTTDKDQIQITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ66</accession>
    <name>A0A7K2ZQ66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_35920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001632">
        <property type="protein sequence ID" value="MYW34521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="522" mass="54470" checksum="974900F2D4BCC54E" modified="2021-04-07" version="1" fragment="single">MAPDSEANGGGFSDGSDAWGVGGVVGDGRYRMTYRLGRGGMAEVYAAEDVRLGRTVAVKLLRSDLAEDPVSKARFTREAQSVAGLNHHAIVAVYDSGEDTVGGQTVPYIVMELVEGRTIRDLLLTAEAPPPEQALIIVSGVLEALAYSHQHGIVHRDIKPANVIITDSGAVKVMDFGIARALHGAQSTMTQTGMVMGTPQYLSPEQALGKAVDHRSDLYATGCLLYELLALRPPFTGETPLSVVYQHVQDIPVQPSEVSDVVPPELDGMVMRSLAKDPDDRFQSAEEMRGLVQYSLQMLQVQGGHTGTWNTGPVALGEGGQTPPHGMTGSTRAMGHPMHGDTSQGPILPPMNPDDGGYNGYDAGQGGRRGGGRRNKMWLFVLLALVAIGAGVAFAINAAKDDGGGKKTPVTPSTSVSSSEEEPSEKPSDEEEPTEEEPEQPNTSTGGQTQPEPPPYTPPPTKSQPSFTPSPTPSDNTDAGTTDGNTNEGSTGEPSGDPTDPTTDPGTPGGGNGGEPGGSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ87</accession>
    <name>A0A7K2ZQ87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_35915</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001632">
        <property type="protein sequence ID" value="MYW34520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="551" mass="57893" checksum="B7479524F5235101" modified="2021-04-07" version="1">MSQDGAQGRYAGGAVAGGRYQLRDLLGEGGMASVYLAYDSALDRQVAIKTLHTELGREQSFRERFRREAQAVAKLQHTNIVSVFDTGEDELGGALMPYIVMEYVEGQPLGSVLADDIRQHGAMPADKALKVTADVLAALETSHEMGLVHRDIKPGNVMMTKRGVVKVMDFGIARAMQSGVTSMTQTGMVVGTPQYLSPEQALGRGVDARSDLYSVGIMLFQLLTGRIPFDADSPLAIAYAHVQEEPVAPSTINRSVTPAMDALVARALKKNPNERFPSAAAMRDEIARVLNASGGRTGAPVIVAGGGPANSGSGVGSAVFPPVDQATPAPQSVQTPYQPHPQSPYQPGPSGPYNQPAPTPAQGYGYPQAAQGYPTGPLAHQTPPPYSINPQHQTAVGTTGGGSSRRNMPVIVGSIVVALLAVGGLITALALQGDGKDDEAGKGGDPGTSETSTDEGYRPPERNRTMKTTACTDASEDSNDPKKVQAPNFVYKDILSAKECAQAAGWTIKEIEEPGNTYAEGQIVGQFPSSGTAVSERGAHFELKISTGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ89</accession>
    <name>A0A7K2ZQ89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching protein GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgX</name>
        <name evidence="5" type="ORF">GT040_36030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001636">
        <property type="protein sequence ID" value="MYW34541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="184"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="729" mass="81257" checksum="454A642F2DED73DE" modified="2021-04-07" version="1">MEVTGTEAVRAEPRAPVVWPGAPMPLGARFRVGPDGVAGTNFALWAGGAEAVELCLFDEDGNETRCPLTELTHEIWHGFVPGIRAGQRYGYRVHGRWDPWTGARWNAAKLLLDPYARAVDGTFTLPPEVYGHVRDWPQQHVADTVRDDRDSAPYVPKGVVVHDDDDWVEDRRPKTPWADSVIYELHVRGFTKLHPDIPPELRGTYAGLAHPAAIDHLTRLGVTAVELLPVHQFAHEDHLLRRGLHNYWGYNSIGYFAPHADYSASGSAGGQVGEFKRMVHALHSAGIEVILDVVYNHTAEAGELGPMLSLRGIDNRGYYRLQHDPRRYADYTGCGNTLHVVQPHVLRLITDSLRYWVTEMGVDGFRFDLAAALARSMHDVDMLSPFLAVIAQDPVLRRVKLIAEPWDVGNGGYQVGAFPPLWTEWNDRYRDAVRDFWRGALPDVRDLGYRLTGSSDLYAWGGRRPYASVNFVTAHDGFTLRDLVSYERKHNEANGEGNRDGTSDNRAWNCGAEGESDDPEINALRRRQLRNLLTTLLLSTGVPMLVAGDEMGRTQGGNNNAYCQDNEIGWLDWSLLEQPEWRELTELTARVLKLRQTHPVLRRRAFFSGRAQAPDGLRDLAWFTRDGREMTEGDWYAPAATLGLYLSGRDIPGRDARGEPVTDDSFLAVLHAGAEPVAFELPGAPWAAAYELVLDTSREDQAEPPGTVLEGGTELTVPARSVLLLRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ92</accession>
    <name>A0A7K2ZQ92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein WhiA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">whiA</name>
        <name evidence="2" type="ORF">GT040_35785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001628">
        <property type="protein sequence ID" value="MYW34495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_WhiA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="81" mass="8552" checksum="19208040F76AE576" modified="2021-04-07" version="1">ALEILGEEVPEHLAAAGRLRMEHKQASLEELGALAEPPLTKDAVAGRIRRLLAMADKRAQDLGIPGTEATLSEELADGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQA3</accession>
    <name>A0A7K2ZQA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001636">
        <property type="protein sequence ID" value="MYW34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029794977" evidence="1">
        <location>
            <begin position="20"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="489" mass="50013" checksum="4C75563F0DFDCED3" modified="2021-04-07" version="1">MTGVLAGSALTAATGTASAAEGAGTAAVVPSGPGMELSAASFTQMTVDEASRRVWIAGDRAYPDGSRRGEVVGLLYGGVGPAIASADGAAPLSGVAVAPDGSKLYAGQSDHIASYAHENGSLSPLAPVPAPADGCGRELVHTGGRLFFTSRPAASPEDCSGAPGSVSVAAASADAPAGVVMYTGTEVHLEGGPGGLLVTAPERWSPTDDPDLGIYRVTDGAEGNVLEFLGERRFGEDGTGQGMDFRDADFSADGSVLAVADGVRGTVLLDGQDADFRENPYAPLPQGVAPTAVAFSPDGKWFAQGGAASGDTADLTLAFADPSVERQPLRISFEDEAAGHRVVPRGMEFSGDGQQLFVVTSDQAGTKFWLHTIQTREALAPSRIVDVAHGPAVAGGPFRVTGRLDLDGLEPTEAPKITAQRLNGSEVTDLPPVPVAEDGTFVLEDVLPDRAGHVLYILGYAGGEHHQVSDHWLAVETAEAPSTVPRDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQG9</accession>
    <name>A0A7K2ZQG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_36445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001655">
        <property type="protein sequence ID" value="MYW34624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="3">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="2">
        <location>
            <begin position="176"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="35982" checksum="0306BD0B627D480B" modified="2021-04-07" version="1">MITTHVKRAFKYRFHPTDARAAELSRTFGCFRKVCNLALAARSEAWTLRQERVNCNATSAMLTAWKKTEELAYLSEVPSVPLQQTLRHLQGAFGNFWQKRAKYPTFKSKKKTRRSAEYTTSGFHYRDGKLTLAKMSERLDIVWSRALPEGATPSTVTVSQDAAGRWFVSMLCDDVPAPMPGTTNAVGIDAGITSLVTLSTGEKVTNPRHERKDRAGLAKAQRNLAKKTKGSSNRAKARRKVAKVHARIADRRRDHLHKLTTRLVRENQWTCACGVTHDRDVNAAKNVLAEGLSVTVCGAGVRPQRSSPGGQSATRQKTPRREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR62</accession>
    <name>A0A7K2ZR62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TerB family tellurite resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001692">
        <property type="protein sequence ID" value="MYW34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16155" checksum="0A3A542E8B36C2C5" modified="2021-04-07" version="1" fragment="single">MRSAKGQRALRPVLCGIRTVWDAVGDGAFFCPGCGGDRNYRRLTGRRRLTVLGIPLAGRGETGPVVECAACRARFAPDALDHPTTTQFSSMLREAVHTVTLAVLAAGGTTSRTVLDTAVGVVRDAGLDDCTQEQLYTVVEVLAADTGYGGRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR75</accession>
    <name>A0A7K2ZR75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_37655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001700">
        <property type="protein sequence ID" value="MYW34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="500" mass="52300" checksum="F6DFC3C9AADAB818" modified="2021-04-07" version="1">MSTPDHTASWVAVALVVLATVLVGGFGLRISRTTSDFYVASRTVRPRLNAAAISGEYLSAASFLGVAGLVLLHGPDMLWYPVGYTAGYLVLLVFVAAPLRRSGAYTLPDFAEGRLESLHVRRLVSILVVGAGWLYLVPQLQGAGLTLKILTGAPGWLGDVLVATVVMVAVAAGGMRSITFVQVFQYWLKLTALLVPALFLVLAWQGDGRPRVSFDDQFAVFRADHPLYATYGLIVATFLGTMGLPHVVVRFYTSPNGRDARRTTVAVLALVGLFYLLPPIYGALGRLYAPELRHGGDADAAVLLLPARVIGGLGGDLLGALIAGGAFAAFLSTASGLTMAVAGVITQDVLPSRGVRHFRLATVLAIAVPLAGSLLVSRVPVADAVGMAFAVSASSFCPLLVLGIWWRRLTPPGAIAGLLLGGGSALLAVAITVSGAVRPPGWPHALLAWPAVWSVPVGFLAMILVSLATPGRIPPGTNAAMTRFHLPEALTSARGAGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR79</accession>
    <name>A0A7K2ZR79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3515 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001707">
        <property type="protein sequence ID" value="MYW34871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="16012" checksum="F7F5B6CDE76DAAD0" modified="2021-04-07" version="1">MTRNIHGPLRLAAALTACTALLGACGGGGYNLSTPPFSGSPACDTLAGELPAQLGGFDLERSDVTGAAAWGDGDVIVYCGMPEPEAGGDCFDEGGVDWVAQPPTDDRTAKMFSTQGRDPGVQVRLRNETTDASAVLSVLGPAVKSIEVREPCAAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRJ0</accession>
    <name>A0A7K2ZRJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_38170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001731">
        <property type="protein sequence ID" value="MYW34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="36"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="367" mass="40816" checksum="C9B331308105D855" modified="2021-04-07" version="1">MPSPLTSEQPRPTAAAGTPETGKPAAGRPPDDGRDHFFDNAKYLAIVLVAVGHAWEPLPSGRLVEAAYTLIYTFHMPVFILIAGYFSRGFELRPDRVWKLITSLLVPYLIFELLYTAFHRLTRDPELPLSLLEPYWLLWFLPALFFWRLSTPIWQAVRAPVLVSLAVAAVATVSPAADGALPLQRILQFMPFYVLGLRLGPEHFAALRRTWVRVVSVPVFALGLLVAYWLVPRTSTSWFFRKNSAQEMDTVGWAGPMATLLLFAAAVVLGACFLAWVPRGRSWMTALGTCTLYGYLLHGFVIRGLRNGGFYEQPFFDTTLGTVTVTAGAAVMVTALCTPYVRSLLRPLLEPRLEWARQRPPKGTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRQ0</accession>
    <name>A0A7K2ZRQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zf-HC2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001755">
        <property type="protein sequence ID" value="MYW35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="46" mass="4572" checksum="EFDC814165B5C771" modified="2021-04-07" version="1">AGAALMAGASPYFAGPAVQSGWAAGAVACALLLAARRRSFDHLETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS04</accession>
    <name>A0A7K2ZS04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001781">
        <property type="protein sequence ID" value="MYW35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="21514" checksum="9285A0630D2701F2" modified="2021-04-07" version="1">MPSNTPDYDLEETIELTTTEQVRAISDPLRNTILSLLHERAATVGELAAAVERPRSTVAHHVSVLTKADLLRVVRTRKVRAIDERYYGRTARMFYVGLGHQKAGGPLPPDFNDFETAAKESAPAHGLGQLRQFIRRARISEDQAAEFWERIEQVVQEFDRLPRSGGTVHGFAVGVYPIPDHPVLPLPPEGDGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSN8</accession>
    <name>A0A7K2ZSN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001840">
        <property type="protein sequence ID" value="MYW35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8446" checksum="850CCFCBEC252764" modified="2021-04-07" version="1">MSTSAISTSTPIYDLLVQERGDALAEARTAAHRTHDEARQVLDWSSVRIAAAQREERAFSAFGRSGDDDGRVRALPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSR2</accession>
    <name>A0A7K2ZSR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001843">
        <property type="protein sequence ID" value="MYW35396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="212"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="33607" checksum="52F7884B3C641228" modified="2021-04-07" version="1">MHTVAVLALDQVIPFDLSTPVEVFTRTRLPGGRPGYQIRVCAERPEVDAGAFTLRAPWGLDGLTGADTVIVPGTATPTAPLSPAVLDALLAAARHGTRIASICTGTFPLAATGLLDGLRATTHWVAADLLAASHPEIEVDPDVLYVDNGRILTSAGAAAGLDLCLHMIRRDYGSAVAADAARLSVMPLEREGGQAQFIVHDYAPAPQGHALEPLLAWLQENLAAELTLADIASRAGMSTRTLMRRFREQTGTTPLQWLHRARIRQAQHLLETTDHSVERIGTQVGFGSPTAFRDRFRRTTGVSPRTYRRSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSS4</accession>
    <name>A0A7K2ZSS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001858">
        <property type="protein sequence ID" value="MYW35450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511419.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001858.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="15738" checksum="C6808D0243FEBBC4" modified="2021-04-07" version="1">MTEIPRDTLQEQTFYEQVGGEETFRRLVHRFYEGVAGDELLRPMYPEEDLGPAEERFALFLMQYWGGPRTYSDHRGHPRLRMRHAPFRVDRAAHDAWLSHMRVALDELGLAPEHEKQLWDYLTYAAASMVNTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSX0</accession>
    <name>A0A7K2ZSX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional activator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001854">
        <property type="protein sequence ID" value="MYW35445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="19814" checksum="DCA71E530F3A5B94" modified="2021-04-07" version="1">EAAGLGLLSALAHDALVRAVRGTTRVSPVAAEAGAGGGGTDPELVFLLKSAANLDIVVELLDLGEADRTSAHVVLAREADGSSGQGRWAVGAGLSRRTAAASALRDLLGQVQLAAEDPGAVVDLGDPLLGDLAPAAIAVGGEPVAVDGPETSFDAVLERLRSAGRDALYVGTTPADLPSGSIATARVLLTVDGEGGPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZT35</accession>
    <name>A0A7K2ZT35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001863">
        <property type="protein sequence ID" value="MYW35457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="40" mass="3881" checksum="4E2A385CAF0DBF68" modified="2021-04-07" version="1">GGGSGLGAVPSQRPGRGGPAAPAGVTPGVTHSRPWTQRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5V8</accession>
    <name>A0A7K2Z5V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000003">
        <property type="protein sequence ID" value="MYW27728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="476" mass="50654" checksum="94F83593A46662D3" modified="2021-04-07" version="1">MTQATDHIPEPALGAATGLDTDALLDDPGIRIIVCCGSGGVGKTTTAAALGVRAAERGRKVVVLTIDPARRLAQSMGIDQLDNVPRRVDGIAGDGELHAMMLDMKRTFDETVEAHADAERARAILENPFYQSLSAGFAGTQEYMAMEKLGQLRARDEWDLIIVDTPPSRSALDFLDAPKRLGSFLDGKFIRLLMAPAKVGGRAGMKFLNVGMSMMTGTLGKLLGGQFLRDVQTFVAAMDTMFGGFRSRADATYKLLQAPGTAFLVVATPERDALREAAYFVERLAAEDMPLAGLVLNRAHGSEAARLSAEQALTAAENLDDARIVDQTAGKAGLGDREAPDPAVTAPEAGSTPLSPEHKHKHDPENTEEDTQVNAHSHSHSHANQHEPQAKGSTDSTAEVAVDIDELTAGLLRLHAERMQVVAREQHTRDRFIELHPEVLVTAVAALPGDVHDLDGLRAIGDRLASGSAPAPAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z617</accession>
    <name>A0A7K2Z617_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_00505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000014">
        <property type="protein sequence ID" value="MYW27790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="207" mass="22667" checksum="2258BCF0669892C2" modified="2021-04-07" version="1">MTPPVVHSLREQIREHIVEGIVSGRWKPGERIVERRIATELEVSQTPVREALRELETLRLIESAPNKGVRVRNLTAADLEESYPVRAGLEQIAAELAAPLLGQDCSALEPHVAALHEADRLADGEAQVRHTVGFHREMVRAAGNAVLLHTWEGLGIEVFTALSIRWLGTVQKSYAEEHQALIDAFLAGDPQIGALVKAHVLGCAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6G4</accession>
    <name>A0A7K2Z6G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000057">
        <property type="protein sequence ID" value="MYW27931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6075" checksum="8E8567A48772522D" modified="2021-04-07" version="1">MAANKDNLKPNGDAHATGEDITTQDAHATSKPVTKLGDAHATGEPAGKLGDAHATSEPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6H0</accession>
    <name>A0A7K2Z6H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000057">
        <property type="protein sequence ID" value="MYW27928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="433"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="518" mass="55413" checksum="5E1B44E59CA01B8D" modified="2021-04-07" version="1">MRGDEEWGSIPGLVREAARRYGPAEAVVEGRTRLTYAELGARVERSAAACLAAGVEPGDRVAIWAPNTLDWIVAALGAVSAGAVLVPLNTRFKGTEAAHILRRSRARLLFVTGTFLGTSYVASLRRSEVKLPDLERVVVLAETAPEDYTSWPDFLAAGEGVPAATVRERAADIRPSDPSDIIYTSGTTGAPKGAVITHAQTLRAYEIWSELAGLREGDRYLIVNPFFHTFGYKAGIIACLMRGATMVPQPVFNVDTVLANIAAERISVLPGPPTLHQSLLDHPARDAHDLTALRLVVTGAAVVPLRLVERLRGELHIATVLTAYGLSEASGIVTMCRRGDAPETVATTSGRAIPGTEVRVLGGPGEPGEIQVRGFTVMSGYFEDPETTADALTPDGWLRTGDVGVLDAAGNLRITDRIKDMFIVGGFNAYPAEIEQLLGLHPDIADIAVVGVPDPRLGEVGKAYAVRRRGATVTADDLIAWSRREMANFKVPRAVEFVPELPRNASGKVVKGELRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7E4</accession>
    <name>A0A7K2Z7E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Type VII secretion-associated serine protease mycosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mycP</name>
        <name evidence="14" type="ORF">GT040_02875</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000125">
        <property type="protein sequence ID" value="MYW28242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029837952" evidence="12">
        <location>
            <begin position="30"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="13">
        <location>
            <begin position="53"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW28242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="356" mass="36568" checksum="B2AF9FB16B94DBDC" modified="2021-04-07" version="1" fragment="single">MTRRRPHRVLAAVCAAAVLALTPAPPAHADAIRDQQWALAALHTDRAWQTTKGAGVTVAVLDTGVDGTHPDLVGQVLPGKDLVGFGAGKGDPSWALHGTAMAGIIAGRGNGLGRADGILGIAPEVRILPVRVILESKDPARAKARKTRGTALAQGIRWAADNGADVINLSLGDDSESAHPDPGEDSAIQYALSKGISVVASAGNGGEKGDRISYPAAYPGVIAVAAVDEYGTHASFSTRRWYATVSAPGVDIVVANPDGHYYIEWGTSAAAAFVSGAVALVRAAHPGLDPAQIKKLLADTARDAPAEGRDDARGYGIVDPAEAIEAGSRLRPGELSAQTATAGHRRKFFGPGPTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7J2</accession>
    <name>A0A7K2Z7J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14630" checksum="526B7BFDD47119D7" modified="2021-04-07" version="1">MTDVLHQAAHLLNWERGITDTTVRGAYHNGSFLEAAEEVGLHWPVGRPRVRGRGYATPELTEGARSLHEQTLKELPDAIARVLPHLVAPTPSRTRAPDRLTLACGCDEPRKIKISPTVAAQGDITCGVCGETFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7J3</accession>
    <name>A0A7K2Z7J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="334" mass="35628" checksum="C9D34AC256A6FE6D" modified="2021-04-07" version="1">MATPMTAAQFVKALKDEGVDVQEYRSWRTHNRNHKGPWRDLNGVVIHHTAGSNSLALCYDGMAGLPGPLCHTHLSKSGLATMVGYGRANHAGAFPANAFNAMKNEASTHPRPSGPETVDANAHTYGIEIENLGNGKDFYPQKQYDTAVRWAAAICRFHGWTADSVIGHKEGTTRKIDPKGPIGSTDGPAFDMDQFRKDVATRLKTKDEEPKPTTPAKPPTAPKPSNPTKPAKPTTPAKPTVDLSNVIAAARRDPGLKQGGTTHPADVKLVEAALQAEGLLGAAYAKDGSFGSLTRAAYAAWQRRCGYTGSAADGIPGKVSLERLGTKRGFKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7M7</accession>
    <name>A0A7K2Z7M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="7497" checksum="A8AF3B72B5666B4C" modified="2021-04-07" version="1">MTKSTTAPVQGAAFAAACVVLIAALPVQAFVLMLSMGAAHGAFAAVPAIGYGTSVLFVLGANLLAGFTRRLFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Y8</accession>
    <name>A0A7K2Z7Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF305 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000171">
        <property type="protein sequence ID" value="MYW28451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029857321" evidence="1">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="43"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="21550" checksum="11B1B2893299F1FA" modified="2021-04-07" version="1">MVLAGAAVLLLAVGLVALMVVRPSAASPSAKAALSAPAEESADAGFARDMAIHHQQAVEMSFIVRDRTDDEDVRRLAYDIINTQANQRGMMLGWLEMWGLPKSSAKPPMAWMGHTVTPTGDGSLMPGMATDAELEALEAAEGKAAEVLFLRLMTVHHRAGVDMARAGAEAAGTDVIRNLAQGMVSGQQSEIGLMADMLKARGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z869</accession>
    <name>A0A7K2Z869_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_04280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000195">
        <property type="protein sequence ID" value="MYW28508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029863347" evidence="2">
        <location>
            <begin position="40"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="35"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="194"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="488" mass="49730" checksum="C7A18E71EDD827A5" modified="2021-04-07" version="1">MGSRTHRRTATTRTKAVGAIVAAAVIGGTVFALTGTAQAAAVGAAYTRTSDWTSGYTGQYVVTNETDKTLTDWTLQFELPAGTKIGSLWNGEHTVQGNRVTVKPASWDKGLAPGKSVTVGFVTSATGTAGDPASCLINNATCSTGGPAPTPSGRPTDTPTTAPTASASPSASASTPTPAPTATGRPGGGGETGSRFAPYIDTSLYPAYDLLDTAAKTGVDEFHLAFITSGGSCAPLWGGVTGLGDDQVAKQISALRAKGGDVRVSFGGAAGAELALNCSSAADLAAAYGKVVDAYQLTKVDFDIEGAALPDAAANTRRAQAITQLQKKYPDLDVAFTLPVMPEGLTRPGVDLLADAKKNGVRVDAVNIMAMDYGPAYSDDMGVYAIQAATATQAQIKGVLGLSEAAAWKAVAITPMIGVNDVVTEIFTVEDATQVVKFAQEKGIGRLAMWSGTRDKACPGGPKPAADATCSSIDQEPLAFTKAFAAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8L5</accession>
    <name>A0A7K2Z8L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000229">
        <property type="protein sequence ID" value="MYW28663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="334" mass="35736" checksum="6411C789D10B9756" modified="2021-04-07" version="1" fragment="single">MGAVITLLSALLLWSLWRNGYLPYRLVPLKLFTPGEWWNPGTSGGPRTIEGSDALTVYEALLFGLLTYGCGRIGNFSELFRRHVVRRGQPFLALAAAVAAGLTQLLVWKETLPVVRPVLVLVAAVAGGEIYQSQTVVNVIYALIAAAVLYPFARLGRWRELLAARRGRGTGTPAPADTASAPTTATSADQWPELRAAGWTDAADTLTAEVRTGRMNDVDVARLRHAWTQATRSPDRLAPLAEAVLRTGGAAALHPSGDRDLPRRTARHDVLTGQVRIGRCADDPHNPYARRSTGIALDPTLLGTSLLAVGPPGSGKSARLVRPVVEALGLRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8M2</accession>
    <name>A0A7K2Z8M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two pore domain potassium channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_05330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000246">
        <property type="protein sequence ID" value="MYW28704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="8">
        <location>
            <begin position="133"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="25408" checksum="9B3452B2F65CE9E9" modified="2021-04-07" version="1">MSDRPVHEPPARLTRWEQRTEVPLFVAGLLFLTGYAVRVLTPHEAEPWNDLALTLVWSTWLVFLVDYLTRLRLSGLGSRFLRVRWLDTVVLLLPLLRPLRMVKVYQAVQRRHDRPRLDLYARVMAYAGMTAVLLGFASSLAVYHLEHKAPDASIRTFGDAVWWACATLTTVGYGDATPVTFWGRVVATGLMACGLALLGAVTGSFSSWLIQVFTREDEKRPPERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9J8</accession>
    <name>A0A7K2Z9J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000313">
        <property type="protein sequence ID" value="MYW29026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241710.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000313.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13425" checksum="08FA28B70576C46B" modified="2021-04-07" version="1">MSGPRRERRKTDPALSDPERLYVITGDLDDSERAALDLVTMVVAQAEPSPTFQPEQAAILRLCQAPLSVAEISAYLSLPFSVVTSLLSDLLATELIESRAPIVRATLPDRSLLEAVMHGLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Z5</accession>
    <name>A0A7K2Z9Z5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000357">
        <property type="protein sequence ID" value="MYW29164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023932">
        <property type="entry name" value="Uncharacterised_CE1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04037">
        <property type="entry name" value="LLM_duo_CE1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="222" mass="23492" checksum="CE4B8A0C394C1F25" modified="2021-04-07" version="1">MFATTPLRIVAVSAGLSQPSSTRLLADRLAAATRERLAAEQDRDGREVEVRVIELRDLAVDIANHLVSGFPSATLREAIDAVTEADGLIAVTPVFTASYSGLFKSFFDLIDNTALTGKPVVIAATGGTARHSLVLEHALRPLFAYLRAVTVPTSVYAASEDWGSSGDEYTEGLPSRIRRAGGELASAVLGRTVSGASRAPGLDDGEDAVVPFEQQLADLRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA63</accession>
    <name>A0A7K2ZA63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000361">
        <property type="protein sequence ID" value="MYW29192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029659499" evidence="2">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8354" checksum="76B7F7662CD5D8C1" modified="2021-04-07" version="1">MSAMAKKASNFKKSKTGLYVALGSTAFGAISVAKQAKLARNDNDVLRLVDAAVSAAAIVTGLAILYRELKRLGDDDVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA80</accession>
    <name>A0A7K2ZA80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000370">
        <property type="protein sequence ID" value="MYW29238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="18786" checksum="21F35021F117CB73" modified="2021-04-07" version="1">MNDGRVVGADDTVTFTFEGEKPKAAKGQFSPMACPEVNDRPTYTVKGSPHFLPDKKKPQSTWLLPRQTVSWAVSGSHTFTWEIGASAEAEAGAILAKAKVSVDTSISNSRTWNSTQTVTDTNTTSKGYRAVLGQVGWKLTAVKTWIAPPCNVKKKTITVVAPRKGDMSIGRQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAA1</accession>
    <name>A0A7K2ZAA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRPBCC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000381">
        <property type="protein sequence ID" value="MYW29276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16669" checksum="393CA2C2902853DF" modified="2021-04-07" version="1">MNGGTRQGIDLTRVLNAPQRRVFAAWTSPEDFAAWYGGEAEVPLDRVSMDVRPGGAWSLVIVMPGVEMPFHGVYREVSEPDGLVLTLKDGSAPGDPEDTQGETITVTFTDLGHGTTELAFQQRGGNLTPEQYAAAEDGWEAFFDTLAARLATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAH0</accession>
    <name>A0A7K2ZAH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000402">
        <property type="protein sequence ID" value="MYW29333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="164" mass="17706" checksum="4F8634E514EA9B1A" modified="2021-04-07" version="1">MFPALLAGVAMVALSSCIPPNGPITYSGFRMEGAGLLVAMPLCPGETVESAEIVVPRKDKKEGGFETLWSAREPRTAEARGGVFQVNGPDSFARVTKELSGTLPDEFYVDTRQVRDGKEVSGSGYVDLTELDSAELRDDEFITHKGKVMTRDEINAQAYCGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAJ8</accession>
    <name>A0A7K2ZAJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000406">
        <property type="protein sequence ID" value="MYW29380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="18175" checksum="D907FB18C764FC19" modified="2021-04-07" version="1">MATETSDPRSGAGPSRNSRPPTAQAALGVGVIVEDGQGRVLLGRHHSGTWELPGGKVDPTHESVAAAAARELCEETGLTVDESVVDVFAMLHDVIGGINRISMAALVRLHSGIPEVTEPHLISAWRWTAPEELPTPLFDPSAQILAAWRPDLCLIHPPAHLLRITGAGDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAK6</accession>
    <name>A0A7K2ZAK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000385">
        <property type="protein sequence ID" value="MYW29295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7278" checksum="BACA7B60F2A01EE8" modified="2021-04-07" version="1">MSDNSISITVELHGGPLDGQTTPVTLTDEDPWVGLPNDGCAFPGGSSIYAPDTHGRWVWQDDQPARTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAZ1</accession>
    <name>A0A7K2ZAZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000445">
        <property type="protein sequence ID" value="MYW29520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="6592" checksum="56714596856D399C" modified="2021-04-07" version="1" fragment="single">VARVDWTAAGTAGGAGVPGDIAGGPVAQALLEEILVDPAVSGPDSADRIAVAHTGEEAIALVPLPAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB05</accession>
    <name>A0A7K2ZB05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_09670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000449">
        <property type="protein sequence ID" value="MYW29536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="33444" checksum="7168DD050D9ED96E" modified="2021-04-07" version="1">MKTTDTPASGADAKVPAQRTGTAPTGSSAPAKKSEGQVLNVFSHGVLILWAVMVVLPLFWAVMSSFKTDSDIFNTPWSLPSSLNFDAWGRAWSQAHMSEYFLNTILVVGGSLVGTLVLGSMAAYVLARFEFPGNRFIYFLFVGGMSFPIMLALVPLFYVMDNMGLLNTIHGLILVYIAYSLPFTVFFLTSFFRTLPTSVAEASIIDGASHTRTFFQVMLPMAKPGLISVGIFNFLGQWNQYMLPTVLNTDPEKRVLAQGLVELASSQGYKGDYSGLFAGLVIAMLPVLAAYIIFQRQVVSGLTAGALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBE6</accession>
    <name>A0A7K2ZBE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000468">
        <property type="protein sequence ID" value="MYW29653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="11490" checksum="5EEC340291F924CA" modified="2021-04-07" version="1">PANAYGAALPWPESPDGAGHKPGRKAGALVVLVDGELTLYMERGGKSLLAWPSDPESPALLAAAEALAASARAGALGTVTVERTNGASSLTSPMGRTLEAAGFLATPRGLRLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBI5</accession>
    <name>A0A7K2ZBI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rpsD</name>
        <name evidence="11" type="ORF">GT040_10660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000490">
        <property type="protein sequence ID" value="MYW29727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015607373.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000490.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="10">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="92"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW29727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="23516" checksum="57D83E578343F2D3" modified="2021-04-07" version="1">MPNQSRPKVKKSRALGIALTPKAVKYFEARPYPPGEHGRGRKQNSDYKVRLLEKQRLRAQYDISERQMARAYDRAKKAEGKTGEALVVELERRLDALVLRSGIARTIYQARQMVVHGHIEVNGGKVDKPSFRVRPDDVVQVRERSRTKVPFQVAREGGYDTDGETPRYLQVNLKALAFRLDRDPNRKEIPVICDEQLVVEYYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBQ0</accession>
    <name>A0A7K2ZBQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GT040_11025</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000499">
        <property type="protein sequence ID" value="MYW29800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="15">
        <location>
            <begin position="269"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW29800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="350" mass="38194" checksum="A6375E9D87D2D331" modified="2021-04-07" version="1">MSSQQIPEDNLPVVQETAHGAVEGTDDPFADPGLPAHKPRIQDLDERAANRSERAVAFMFVLSMLSTVGFIASYVIFPVDKIVFIWPFGHVSALNFSLGLTLGFALFFIGAGAVHWARTLMSDVEVAAERHPIEAPAEVKAQVLADFKAGAEESAIGRRKLIRTTMFGALALVPLSGVVLLRDLGPLPEKKLRTTMWAKGKLLVNMNTGQPLRPEHVAVGSLTFARPEGLEEDAHDFLSQIAKAALMIVRIEPDDIKDKRQRDWAHEGIVAFSKICTHVGCPISLYEQQTHHVLCPCHQSTFDLSDGARVIFGPAGHALPQLRIGVNSEGNLEALGDFDEPVGPSFWERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBR3</accession>
    <name>A0A7K2ZBR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000492">
        <property type="protein sequence ID" value="MYW29752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030567365.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000492.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="17807" checksum="6E622AD15437ED00" modified="2021-04-07" version="1">MAEQALITGMGGKEPDIDADAFVAPTSVVIGEVTLAAGSSVWYQAVLRADCGPITLGPDSNIQDNCSVHTDPGFPLTVGARVSVGHNAVLHGCVIEDDVLVGMGATVLNGAHIGAGSLVAAQALVPQGMQVPPGSLVAGVPAKVKRPLTAEELEGIRFNAAGYVELAKAHRAAHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCA1</accession>
    <name>A0A7K2ZCA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000547">
        <property type="protein sequence ID" value="MYW29963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017078">
        <property type="entry name" value="UCP036978_PHPhdr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036978">
        <property type="entry name" value="UCP036978_PHPhdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="127"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="360" mass="39642" checksum="8B0DA766257118E9" modified="2021-04-07" version="1">MRRSWEQAPRTGDRGGGRRSHLEVPMDPVTALRRIAFLLERSQAATYRVKAFRTAAEVVDAMEPGEAAERVAAGTLERVSGIGPRTAQVIREAQAGEVPGYLERLEDEAAAEPAPDTGQELLSRLRGDCHLHSDWSDGGSPIEEMGRTAAELGHEWAVLTDHSPRLTVAKGLSPERLREQLAVVERLNEEWAPFRLLTGIECDILPDGSLDQEPELLERLDVVVVSVHSKLRMDPAPMTRRLEAAVRHPQANVLGHCTGRLLSERGRPESRFDADRVFAACAEAGTAVEVNCRPERLDPPRRLLRKAVEAGALFAIDTDAHAPGQLDWQINGCARAEECGVPAERVVTTWPVERLLEWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCR8</accession>
    <name>A0A7K2ZCR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="12758" checksum="852217889FF67E57" modified="2021-04-07" version="1">MDDLKNLIERVMAEKDWSLTVLARRSGLSTSTLHSWKSGDRATGSRGPSPEKLRQLAEGAGLPVATVFEAAGRHIPAPMDDEDERSFLHLLRSLDGADRTVIKATMEAMAERRTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCY1</accession>
    <name>A0A7K2ZCY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000608">
        <property type="protein sequence ID" value="MYW30203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="9798" checksum="7DAD3BE6814B8240" modified="2021-04-07" version="1">MVGRDARVTGGLRRHGGNRPLPLHKVMDSGNQGYAPQTVPCRPGRCFVVHITSQRGFRRRKWRETSEVPLHFGYAGPWIRPPDRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD94</accession>
    <name>A0A7K2ZD94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">hemC</name>
        <name evidence="9" type="ORF">GT040_13705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000652">
        <property type="protein sequence ID" value="MYW30314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030573744.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000652.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="15"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="238"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="33832" checksum="B39B7942FCADFFB4" modified="2021-04-07" version="1">MTDNSSPGAGNPAPLRLGTRRSKLAMAQSGLVAEAVREVTGRAVELVEITTYGDTSREHLAQIGGTGVFVAALREALLRGEVDFAVHSLKDLPTAQPDDLVLAAVPQREDPRDALVARDGLTFEQLPDGARIGTGSPRRMAQLNAYARSHGLRIETVPIRGNVDTRIGFVRDGELDAVVLAAAGLSRLGRTGEVTDFLPVDTVLPAPGQGALAIECAATSADLAAALAELDDPYTRVAVTAERALLAALEAGCSAPVGALADLLVDGQVVNELRLRGVVGSTDGSSLVQLSTTGPVPTSHDDAAALGRELASEMLAKGAAGLMGERAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDJ1</accession>
    <name>A0A7K2ZDJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AfsR/SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_14345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000667">
        <property type="protein sequence ID" value="MYW30430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="222"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="222"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1137" mass="119921" checksum="03CB31A53B7A9B18" modified="2021-04-07" version="1">MPDDGGDRCAQELGLLLVRPVQGHAQHQQTLGEAHLAEGGPDGRLPLAFGQVAVDERQDALLLQRQMLVQGRQQSLRDGGDGFPAGDVGGVPPPPATRGERLQLAVDEGVLLVHRLDERADVVGAALPQPGPDVVVLAGVMGVQEVDHHQDVVGDEGGALGVTGRHAGDQCGQGVELPPHGVVCADHVAAVGHLLVRLGVHGSSFGAVPFSPPTGRIRLPRPAVAAVGGIGLHGAVQTFGVLGPFEVRAGDQPVHVGGRLPRRLLAILVAGEGRPVSEDSLAEGLWGGRPPRNPAGALQVYVSRLRRALPGMELRRSGGGYQLLAADTDVERFHGHLVRARALAADDRHADAYAAFEAALRLWRGTPYEDLADDESTAAIRAALVEQRDSAQEEAAAALLATGDHAGAVAALELLVHAAPYRERRWQLLALALYRSGRQADALNAVRRVRTLLAEELGVDPGVELRQLEGRILSQDPALSQDPAPDSAPRAATEAVEPGDRPLTSFIGRDGDVALLSRLVGTHRLVTVVGPAGSGKTRLAVEWAGRDAVVRLADVADPAHLVSAVAGTVGVTGATGDPYEALVKRLRLHRKPLVLDNCEHLVGEVARLVVDLLDRVPALRVVATSRSPLGVDGEHHLPLGPLAADDAVTLLTDRIRAGRPGWVGQDTDRRDLRRLADALDRLPLALELAAARVRTFGVRGLIENLDDRFTVLGRIPHSRMTPHATLQEAVAWSFDLLSGEERDLAVRLWPYEGGFPLEAAGPGGLGTLVSLVDQSVVTAETGGGRPRYWMLETIRAYGRSVDADPAASRAAHARWVRELVARAEGDLQGVRSAATMAALRLELPNLRAGLAHDLAHAPAEALRTAARLMWFWIRSGLLAEGNRVLTAALAAAPDAPLGDTVRAKASSAGLFYFTGDVTTARRMLSEANLAVGSEPDHRSLLAEVRYYQALVQLPGGEPAIALEASAEAHAIATGTRTTWLIAAASMAWGAALVMAGRTAEGQHRLRAAVQLADASGLVWTAALSELMQAQTLVDAREGEALPLLSSSLRRFAGEGDLSNQLAVLHNGALALDAADDPAGAALLRDVVHFHQARSGIQPTGTFLQSVVPHGWYEGAPPEEPPTLDDAVAVLTAAARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDJ7</accession>
    <name>A0A7K2ZDJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_14105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000662">
        <property type="protein sequence ID" value="MYW30389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="12474" checksum="B62C3C9CAEEBC3E8" modified="2021-04-07" version="1">MTQHLTLSTRTTAAGPVMELAGELDHHTAPRVRDALAGLALRPGQQLVVDLKGITFCDSSGLTVLIAARNHALAADATIALAAVPERLSRILGITGLGHVFPSHPTAQDAEHAWRTASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDK2</accession>
    <name>A0A7K2ZDK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="14032" checksum="FABE8F445E0ACCA2" modified="2021-04-07" version="1">MRIGELAKAAGVSVRSVRYYEEQGLLTSTRSPSGQRHFRDADIDRVGFVQRLYAAGLSSRTITELLPCVDAPSETTSDAAMERMEQERERLSAHIEELIRTRDALDVLMATNRAHRKTLRRATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDM3</accession>
    <name>A0A7K2ZDM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000673">
        <property type="protein sequence ID" value="MYW30454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="275" mass="29153" checksum="F880B451713B8F72" modified="2021-04-07" version="1" fragment="single">MDVMPQQDPESRRPSQPSPEGPRPPHDATPGADPYVMPAEGATAVPPPPPTLRTTLRRAAFGAVAAGVLLAGALVAVPDGKDDRPKEPGPVERAEAATTAGSPASLSDLTALIGDRQKWVESHPADAPSWATLGSAYVEWGRRSADAAYFGRAEEALKRSLEEQPGERGNGEAWVGMAALANARQDFLAAKRWGETVRKQDPKTWSVYPVLIDAYTGLGDVKAATDATEKFGELRKGVPALARTADLYRGQGWREDALATAREAADRATAPAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE84</accession>
    <name>A0A7K2ZE84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000722">
        <property type="protein sequence ID" value="MYW30628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="21131" checksum="A1FE283A32821BE2" modified="2021-04-07" version="1">MARARSEERRAEILRATLEVIAERGYRGATLGAVAERVGLTQQGLLHYFPTKEALLVAVLEDRDRWDTGGRGGADGAWRLELLGSLVEYNAMRPVIVQTFSALLGESVTEEHPAREFFTRRYTQVRAGMAATLRAEYGDTLPGGLSPERAAVLLVAVMDGLQYQWLLDPEAVDMPGAFGDFLGLLRGAGGPEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZED8</accession>
    <name>A0A7K2ZED8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbamoyl phosphate synthase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000741">
        <property type="protein sequence ID" value="MYW30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="1">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="104" mass="11093" checksum="DCC33F75A9B72391" modified="2021-04-07" version="1" fragment="single">MRGGGGGRGGPPPFAVLVLEDGRAFHGRAYGAVGETFGEAVFSTGMTGYQETLTDPSYHRQVVVMTAPHVGNTGVNDEDPESGRIWVSGYVVRDPARKPSNWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEE9</accession>
    <name>A0A7K2ZEE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide-inactivating glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mgt</name>
        <name evidence="5" type="ORF">GT040_15730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UDPGT" evidence="4">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="399" mass="42941" checksum="B3C8EFADFB3AC7B8" modified="2021-04-07" version="1">MTESPRAHIAMFSIAAHGHVNPSLEVIRELVRRGHRVSYAIPASFADKVAATGAEPVIYTSTLPTDDDPEAWGTELIDNIEPFLADAIQALPQLVAAFGGDEPDLVLHDITSYPARVLAHRWGVPAVSLWPNLVPWEGYEKEVGEPMTAELKQTERGQAYYARFDGWLADNGLGHVPSDDFVARPRRGLVLIPEALQPHADRVDRDMYTFVGACQGDRADQGEWERPAGAGKVLLVSLGSSFTKQPAFYRECVAAFGDLPDWHVVLQIGGHVDPAELGDVPANAEVHAWVPQLAVLKQADAFITHAGAGGSQEGLATGTPMVAVPQAVDQFGNADMLQALGVARHLPMEEADAATLREAVLALTGDPEVAERSARLREQMAKEGGTPRAADLIEAELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF99</accession>
    <name>A0A7K2ZF99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000808">
        <property type="protein sequence ID" value="MYW30969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="15484" checksum="FFAD0BEE2CDF4ACD" modified="2021-04-07" version="1">MHLYRTVLVGTDGSPSSFTAVEGAARLAAGTRADLVVVCAYQPLSGPELAKAQHELGEEAYQVVGSAPAEESLRVARVRAEAQGAASVRLRAEEGEPVAVLMRVARECSADLLVVGNRGLRSLAGRLLGSVPADVARKAGVDVLIVHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFA9</accession>
    <name>A0A7K2ZFA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000819">
        <property type="protein sequence ID" value="MYW31033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="43"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="34251" checksum="8EAF3E7B68FE23CB" modified="2021-04-07" version="1">MGAVLAVVLAAAGCSSTGGKRAEERAAEAAEGRAAVNTPRWTFAMVTHSGDGDTFWDIVQKGAEQAAVKDNINFLYSHNDEANQQAQLVQTAIDKKVDGLIVSLAKPDAMKSVIAKAVKAGIPVVTVNSGSAESKEFGALTHIGQDEAIAGEAVGDELNKRDREKALCVLHEQGNVGHEQRCAGAKKTFDGTMQNLYVDGTNMPDVTASIEAKLQSDKSIDAVVTLGAPFADAAVQAKQTAGSKAEIDTFDLNAKVATGLQTDKLGFAVDQQPYLQGYEAVDLLWLYRYNRNVLGGGLPVLTGPQIITKDDADALADYTKRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFG6</accession>
    <name>A0A7K2ZFG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000855">
        <property type="protein sequence ID" value="MYW31114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="20668" checksum="071D507E1BA136E3" modified="2021-04-07" version="1">MGEIDDAIERADQEGFTRQPPKTLKGQIGFLLKQFGSARAVAAEIGVTAGSVNRYRRGARKHARPDVAAKIDDVVRQRWQPMVRKRRQKQAATTGGITVETRARFGYTAPVGTTDDGRFRRLTVRLPPTYAQRLFDARDTSAGDQEMRKIIAEGFKEIYFQDGGGRATGLSDVTLNDIDYLDLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFR8</accession>
    <name>A0A7K2ZFR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymidine phosphorylase</fullName>
            <ecNumber evidence="6">2.4.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_18535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.4" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000866">
        <property type="protein sequence ID" value="MYW31217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="334"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="425" mass="44452" checksum="EF33C057CE3C6282" modified="2021-04-07" version="1">MDAISVIRTKRDRGELTPEQIDWVIDAYTRGEVADEQMSALAMAILLNGMNRTEIARWTAAMIASGERMDFAALSRPTTDKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKLESIPGWRAHISNEEMLDVLDTTGAVICAAGDGLAPADKKLYALRDVTGTVEAIPLIASSIMSKKIAEGTGALVLDVKVGSGAFMKTIEDARELASTMVALGTDSGVRTVALLTDMSTPLGLTAGNALEVRESVEVLAGGGPRDVIDLTLALAREMLDAAGLKDADPEKALADGSAMDVWRRMISAQGGDPDATLPTARERHVVTARSSGVLTRLDAYDVGVAAWRLGAGRARKEDPVQAGAGVELHAKPGDTVSEGQPLMTLHTDTPEKFDYALKALPDAYDIAPAGTSFAPLPVVRERIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFW7</accession>
    <name>A0A7K2ZFW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAD hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_18580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000866">
        <property type="protein sequence ID" value="MYW31226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="343" mass="36564" checksum="8E6D0CF8AA39C724" modified="2021-04-07" version="1">DAAGRLHCVERPAAIAGDTATSEAAVLHALDTYEAERARSVDVVLLVQCTSPFVSREDIDGVARAVAHEGADTAVTVAPFHGFVWRDGAAVEEGTYGVNHDKSVRPRRQDRPQDFLETGAAYAMDAAGFRTHRHRFFGHTALVPTDPARVLEIDDPHDLARARALAPLLDPAPLPSLADVDAVVLDFDGTQTDDRVMVDSDGRETVAVHRGDGLGIAALRKAGVPLLILSTEQNPVVAARARKLRVPVLHGIDRKDEALKQWCDEQDIAPDRVLYVGNDVNDLGCFALAGWPVAVGSAHDSVRAAARAVTTTPGGYGAIREIAAWLLGPTLTTTPSVPTVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG52</accession>
    <name>A0A7K2ZG52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2786 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000885">
        <property type="protein sequence ID" value="MYW31310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="2">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="397" mass="42461" checksum="2A62F257AC8FE682" modified="2021-04-07" version="1">MEAVIDQACAAALYAEGDAALDTGASLLAAAPGADDDLHRRGEEFVTRAWGRGWHPADLVRFVRLELDERRAVLAATLIAAETARYGELPPRWRAQLAELPGPVPVPRNKPDRFSYASDLLELYRLLLRLPAIEPVGPAPGTAADHLHRPPAPDEPRMLTRIRALLAKAEATGFPEEAEALTAKAQELMARHSIDEALIAARSHSAETPGACRIGVEPPYESAKAILLDAVASANRCQAVWTGDLGFSTVVGFEPDLEAVELLFTSLLVQGTAAMTRAEAGQRASGRKRTKTFRQSFLMAYAQRLGSRLADTTERTTAAADTETGGGTAEGASDLLPVLAARDVAVTETAERMFPRTTTTRVRGATDLDGWNHGTEAADRARVGGSRSGPRDGEIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGD1</accession>
    <name>A0A7K2ZGD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000909">
        <property type="protein sequence ID" value="MYW31386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030566284.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000909.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="27174" checksum="92051D1BB1A39866" modified="2021-04-07" version="1">MDTDERRRGILDTARRDGSVEVNALAVVFKVAKETVRRDLHVLEEHGLLRRTHGGAYPVESAGYETTLAVRTTRNVPQKSRIAAAAADLLGDAETVFVDEGFTPQLVAEAFPRDRPLTVVTASLAVATVLADAEKISVLLLGGRVRGSTMATVDHWASKMLAGFVIDLAYVGANGISREYGLTTPDPAVSEVKAQAMRSSRRRIFAGIHSKFGAVSFCRFAGVGDFEAIVTDAGLSSAEAQRYSLMGPQVIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGG7</accession>
    <name>A0A7K2ZGG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000912">
        <property type="protein sequence ID" value="MYW31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="57" mass="6683" checksum="8E73AA8192EBF703" modified="2021-04-07" version="1">MAKGRSCQVCRQRMSVKSEQRQPMGSWVVYECRNPACKNWIASGQRNRFGEKVFEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGM7</accession>
    <name>A0A7K2ZGM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000931">
        <property type="protein sequence ID" value="MYW31492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="130"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="341" mass="36397" checksum="D9A8F89A4891EB3B" modified="2021-04-07" version="1">MVQAYGADTGNGSAERPQPDESRFRSLLKRAARDRGIWRRGIVLALCSVVLTLVMVVHAQIPNRVGNLGSLIETFLPWIALFIPLLLLLALLRRSATALIALLLPAVVWLNMFGGLITDKSGTGGDLTVATHNVNAGNPDPAGTAQQVAGSGADVVALQELPGGQVSTYEKSLAARYPYHSVQGTVGLWSKYPLSNTRPVDIKMGWTRAMRSTVKAPQGEVAVYVAHLPSVRVKLHAGFTANQRDNSADALGEAIADEPVERVVLLGDLNGTMNDRSLNAVTSQMRSTQGAAGDGFGFSWPASFPMARIDQIMVKGVEPKSSWTLAATDSDHLPIAARVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGP4</accession>
    <name>A0A7K2ZGP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000935">
        <property type="protein sequence ID" value="MYW31510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="10468" checksum="1D0EC808BCE425ED" modified="2021-04-07" version="1">MISPRGEFDMDNTTSLGAEIETMAAVYGGVVLDASSITFADSSFLRMILNTHQRTDLRIAAPSRRVARLFDLAGVDTYLRIYPTLETARALSRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGQ3</accession>
    <name>A0A7K2ZGQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000951">
        <property type="protein sequence ID" value="MYW31541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="22781" checksum="58D3A0AEAA3D787A" modified="2021-04-07" version="1" fragment="single">IATRALDSVTVDPVRRTARIGAGASWGRVIEAAAPHGLAPLNGSSPSVGAVSYTLGGGLGILARKFGYAADHVRSLDVVTADGTARRVTPEREPELFWGLRGGGHRLGMVTGLEIALVAVERLYGGSIVFDGAWAGEVVRGYLEWTRTVPDTLTSSLAALVHPDLPQLPEELRGRYVISVRVAFTGDAAEGERLVAPLRAIGAGSVRGSHGAADSPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH37</accession>
    <name>A0A7K2ZH37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_20720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000975">
        <property type="protein sequence ID" value="MYW31635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512135.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000975.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029772000" description="Cytochrome bc1 complex Rieske iron-sulfur subunit" evidence="11">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="46"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW31635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="13930" checksum="AE6AE7571B1235CD" modified="2021-04-07" version="1">MPGLPAARRTVLKGAALAGAAGLGAAACSTESKLGHAKSPTPTAPVALGEASEVPVGGAKLYREQRLVVSCPAKGEYKAFSAQCTHGGCVLSKLEGTEGHCACHGSRFDTTTGEVVQGPATVPLPAVPVTAEGGKLVAGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHM1</accession>
    <name>A0A7K2ZHM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_21870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001027">
        <property type="protein sequence ID" value="MYW31850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="595"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="874"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1103" mass="115025" checksum="E545C8753D5A0FF3" modified="2021-04-07" version="1">MSRQVLSVGPGDRFSTIGEALAAARTGALISVRPGTYAENLVIHTRVTLTAAEGRGTVEIRPRSGSVIALRADAVMLSELTLRGGDAELPAVDVRRGQAAFDGCEIVGAAWTAMLAGGTGSLALRDCRVSNPQGAGIVVTSTTPTTVESCTLEHLGTSGIVLAEQGEARIRDCTVRGARGNGLLANGETRGTVEDCDISSTDKPSIALEENSAVSVVRTVVHDTSTGVHLSSAGRTTLEDVRVTGASGNGIALAKGTDPVLRRCRVSRVRGHGMVVTDRARGTFEDCWVDGAQGAALRVAGASSPALTGLTVRDCEGAGLLLEEDAAPELDRLEVIGSSPAIALQGGANPLLRRARLVEPVGDGILATRDARGRVEDCEIVRPKGAGVRVASGSTLYLAGGGVSDTATSGLIVEDGGNVTVRDFRVEISGEEGVVVAAGGELTANRTTVHAPKGHGYLLQEGALASLSGCEANGGAQDGFRVESTAPVSLVNCTARENEGGGLVQTAPGERLAVEGLNSVSNGKRDAWGSGSAENTDPAGSGAADGPAPDRADGPLGALNALIGLENVKQQVRTLVNLTQLAQRREQLGMPAPPMSRHLIFAGPPGTGKTTVARLFGAILAELGSLRSGHLVEVSRADLVAQVVGGTAIKTSETFQRALGGVLFIDEAYTLTADSGNGGADFGREAVDTLLKLMEDHRDDVVVVAAGYSREMDSFLSSNPGLASRFSRTIEFENYSVDDLVAIMESMCAQHQYELGEGTAEALAAHFGAMDRDAGFGNGRAARGVFEEMVDRQAVRLSAQPQVSERDLRLLLPDDVSATAAATASETAAPADDPLTRLGDMIGLAEVKREVADLVNLITTARHRAAAGLPVPSLSNHLVFTGPPGTGKTTVARLYGEVLTQLGVLQRGQLIEAARADLVGRYIGHTAQLTREVFEKARGGVLFIDEAYTLTPRGGGADFGQEAVDTLLKLMEDHRDEVVVIVAGYTDEMERFLASNPGLSSRFPRRIAFADYSSEELVTIVRTQAANMGYECGPGTGPLLKEYFDALPRDRSFGNARLARQVVESMVTRQAGRLSSLAAPTLDDLRILLPADVTAAAPKVVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHS6</accession>
    <name>A0A7K2ZHS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3662 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001038">
        <property type="protein sequence ID" value="MYW31887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3662" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="15391" checksum="E54C9B4908362C85" modified="2021-04-07" version="1" fragment="single">MGVMKRFEQRLEGLVNGTFAKVFKSEVQPVEIAGALQRECDNNATIWNRERTVVPNDFIVELSTPDYERLSPYSGQLGDELSGLVRDYAKQQRYTFMGPIKVHLEKADDLDTGLYRVRSRTLASSSSQQDQFDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHZ3</accession>
    <name>A0A7K2ZHZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="217" mass="22649" checksum="F6B7801B6AD8C7D8" modified="2021-04-07" version="1">MTAATPSPSPDVLAAFEAAKGFMPVHEGLALHAAATEAGALGLPLLEVGTYCGRSTILLADAARTAGVGALTVDHHRGSEEQQPGWEYHDPSVVDPEVGLMDTLPAFRRTLHRAGLEEHVVALVGRSPQVAAVWAGPLGLVFIDGGHTDEHANGDYDGWAPHVAEGGLLVIHDVFPDPADGGQAPYRVYLRALASGAFTEVSVTDSLRVLRRTGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIF1</accession>
    <name>A0A7K2ZIF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001103">
        <property type="protein sequence ID" value="MYW32121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="6482" checksum="4FB74A28E199511E" modified="2021-04-07" version="1" fragment="single">MGAVACGLALADVVAVRFGGAPAGWRTAVLDWAATHGPADSAVRIGGAVAALAGAWLLGCALLPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIK6</accession>
    <name>A0A7K2ZIK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="29371" checksum="C0D555E10E771058" modified="2021-04-07" version="1">MARSARPVVHYMATRPDGTVPPTDTYLAAYHRAQGETIPTVNLADNIGQVIDHPTPGRKWYTDRPFGYFHMYTRPGEILERIEDGWPIRLWIVEPLGETGNWGGHFYPYWLLSQQIRVVEETDAWKAFGHRGAQVLATLAQLPDLAGQWATEWTADPEGTLRTYKAWEKRVDHTRALTGWASCRAEYSRREAGLQAANELAGNAAGEAAAAAGADPHAVTLIQLRARCLVAGQLMFDRIRNGEYEQSIRGLLLGAGLDTPAPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIM4</accession>
    <name>A0A7K2ZIM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AfsR/SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001100">
        <property type="protein sequence ID" value="MYW32119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="143" mass="15307" checksum="6D4A2C4F72C929FA" modified="2021-04-07" version="1" fragment="single">AWPDGVWLAELAPVDDPDAVPEAVLSALGARETVLRGAGAEELRAVDRTGDDPLVRLTEHCAPRRMLLLLDNCEHVVGAAAALTDHLLTHCPRLTVLATSREPLGVPGEFVRPVDPLPDPMALRLLAERGAAARPGFRTDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ38</accession>
    <name>A0A7K2ZJ38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1295 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_24650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001153">
        <property type="protein sequence ID" value="MYW32370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="DUF1295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="PTHR32251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="S5A_REDUCTASE" evidence="6">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="28836" checksum="B4765622F6ABF6E0" modified="2021-04-07" version="1">MSGFAWSAFASGLAGAAGAALAVMLVTFAIALKKGVHRIVDVAWGLGFAAVALVSYGLSVGEGDDTRRLVVTVLTVVWGLRLAVHIGRRGRGHGEDPRYEKMLAKAPGHPQLYALRKVYLLQGALVWLVSLPVQAAHYLTGPLVWWAWAGAVLWAVGLAFEGIGDHQLARFKADPANKGKIMDRGLWSWTRHPNYFGDFCVWWGLFLFVCQAPAAAAATVVAPLVMTFLLTKGSGAALLERHMADRPGFAAYQARTSGFFPRPPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ40</accession>
    <name>A0A7K2ZJ40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flap endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001153">
        <property type="protein sequence ID" value="MYW32362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="11"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="315" mass="34235" checksum="06587250CDC1C5FF" modified="2021-04-07" version="1">MVWGIIGSVTRRLMLLDTASLYFRAYFGVPDSVRAPDGTPVNAARGLLDFIARLVQDHRPDELVACWDNDWRPQWRVDLIPTYKAHRVAVETPAGQSDEEEIPDTLSPQVPIIEDVLAALGIARVGVTPYEADDVIGTLTARATGPVDIVTGDRDLYQLVDDARQVRVLYPLKGVGTLQMTDEAWLREKYGVDGAGYVDLALLRGDPSDGLPGVPGIGEKTAAKLLDAYGDLAGIMAAVDDPKAKLTPSQRKRLDEARDYVAVAPKVVRVAQDVPLPEFDPALPREPRDPAALEALAEQWGLGGSLQRLLTTLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ69</accession>
    <name>A0A7K2ZJ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_24760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001157">
        <property type="protein sequence ID" value="MYW32392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="155" mass="14933" checksum="1BE435426F9DB407" modified="2021-04-07" version="1" fragment="single">MNVLGIIASAVAALFITVVLAKGVRRTALRSGIGREPGGRPSRAGVVRRLGGATLVIGVGTAAAAGSALGAAGDGGRAVTGLLAGAGIVAALGLVHEVRPLGVPLRMAVQTAAATLAVCLAGLSPVAGVLAVVWIVLVTQAFALLDTSDGALATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJF0</accession>
    <name>A0A7K2ZJF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001183">
        <property type="protein sequence ID" value="MYW32473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="22605" checksum="048B92B835698484" modified="2021-04-07" version="1">MIPELETVVGALPTESTQQAVGYPTLFLLVALGSLVPVIPTGALVSSAAVVAFHQASPFSLLFVFAVAAGAAFLGDVCLYWLGQRGVRSNHGSKWLEALTRRAAPERLAQAQEKLEEHGGTVLILSRLVPAGRIPVMLACLLGKMPLKTFARGDVPACLAWAATYQLIGILGGSLFPEPWQGVVAAVALTVVISGAPAVWRKLRARFGHGTGDATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJF5</accession>
    <name>A0A7K2ZJF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001185">
        <property type="protein sequence ID" value="MYW32477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="166" mass="17824" checksum="7973FA65F0D42747" modified="2021-04-07" version="1" fragment="single">GGTPADDGRRALLETAGRLWSRGVPLDRSALDADHHRVPLPTYPFRRDRYWADLPVSPLLHRVLWEEAGLSDASPAAVGSVLLTGPDAASVSRFARQLAAEGIRLHTGGEEPPDAVVLVAGPAPVQEDADALGRAQETALAAFDEALARLDETRARRMLVLTEDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJP3</accession>
    <name>A0A7K2ZJP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_25700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="352" mass="36136" checksum="D5B88FC30D094CF2" modified="2021-04-07" version="1">MSTTAVERPVPRGATEVRRARVVGLGTLVAFLVLVAALSLAVGARALSPAEVWHGLFAAPDSDQRLTEIRLIVQTVRVPRTVLAIVAGIALGVGGALIQGYTRNPIADTGLLGVNSGASFAVVSAIAVFGLTNPFHYVWFAFVGAALAGVVVFGLASIGRGAGNPLTLALAGQGITVFLMAMTTAVALTDQKSLNALRFWNAGSVAGVGFDVIWPVTGFIAVGLLLALSMLPSLNLLNLGDDVARGLGVNIVLSRAVGIVAITLLAGAATAACGPIAFLGLMVAHVARYMTGPDYRWLVPYAGLLGAVILLACDIVGRLVVRPGELEPGVVVALIGAPFFAVLVWRGKFKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJT8</accession>
    <name>A0A7K2ZJT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7 8">Pantothenate kinase</fullName>
            <ecNumber evidence="4 7 8">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">coaA</name>
        <name evidence="11" type="ORF">GT040_25930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7 8">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="4 7 8"/>
    <dbReference type="EMBL" id="WWKE01001204">
        <property type="protein sequence ID" value="MYW32618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF139">
        <property type="entry name" value="PTHR10285:SF139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7 8" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="10">
        <location>
            <begin position="104"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW32618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="37257" checksum="D0705E89D537A245" modified="2021-04-07" version="1">MITSPARSPQRRTEHAPTPYVDLSRDEWSALRDKTPLPLTADEVERLRGLGDVIDLDEVRDVYLPLSRLLNLYVQATSGLRGALNTFLGDAGNGHGAQRGTPFVIGVAGSVAVGKSTSARILQALLARWPEHPRVELVTTDGFLLPMKELRARGLTSRKGFPESYDRRALTRFVADIKAGKDEVTAPVYSHLIYDIVPGERLTVRRPDILIVEGLNVLQPALPGRDGRTRVGLADYFDFSVYVDARADDIETWYLSRFRKLRDTAFQDPSSYFRKYTQVSEEEALDYARTMWRTINKPNLMENVAPTRGRATLVLRKGPDHKVQKLSLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJU9</accession>
    <name>A0A7K2ZJU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF389 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001204">
        <property type="protein sequence ID" value="MYW32617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="PTHR20992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="33459" checksum="BDED142059134076" modified="2021-04-07" version="1">MLHLRLIVPAATTDEVVTLLESTVGTAHLVVLPGAARSPAGDVVMCDVAREAGDELIGQLRRLGIDESGAISVEHLDLTLSARAEKAEHEAPGDSADAVLWEELTEATHEESTFSITYVSFLALATMLAACGVMLDNAVLIVGAMAVGPEFGPLAGVSTALVQRAPRLVARSLWALIGGFALAMAITAGFAWLLDAVGLFDKSMIEAERPITGFIWQPDWMSFIVAFLAGIAGTLSLTSAKSGALIGVAISVTTVPAAANAAVAFSYSDYQQTIGSGQQLLANLGGIVLAGTLTLLLEKALWKVRRTRKPPASTPGASVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK14</accession>
    <name>A0A7K2ZK14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001221">
        <property type="protein sequence ID" value="MYW32681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="572" mass="60505" checksum="F0C1742982C419E0" modified="2021-04-07" version="1">MTDDASTDVLIVGAGPTGLTLALDLARRGAAVRIVDKSPAHPRTSRAKGPNPRSLEILADLGVVDEVLAAGSAPLPMRVYRDHRPVAETDPWADAAPTPATRFDRPWLIAQWRLEEILRARLAAHGVHVELGREVVGLVEGAGERHVDVTFAEGRAERARYVVGCDGAHSPVRKLLGITFDGTTAEDQVMVSGDVELDHEDLGRDRWHQWFDADGAVMLCPIPGTRRGWWFQAGPERDADGRPLAPTLDGFRRLFTRHTGLPGRHLARAELLSTYRVNVRMADRYRVGRVLLAGDAAHVHAIAGGLGMNTGIQDAFNLGWKLGQVLAGQADAWLLDTYEEERLPVAAWTLDLTSDRLRATLEAIREPGGHLGTAMTPETAGLGIGYRWSSLAGKEAGTGTGTETEAGTGAGTEAGTKADTEADTATSAPHPGNRSPGDRAPDAPCRDAATGERTHLYGTFAGPHTTVLGFGPASAAVLREVAATYGEGPGVRACRVYAAHEDQGTAEPGSLIDDQGHAAAAYGIGAGGSGLVVIRPDHHVGIVAPVGDPGSVREYLRRLHGAPGMVDAVRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK31</accession>
    <name>A0A7K2ZK31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001230">
        <property type="protein sequence ID" value="MYW32701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="348" mass="36711" checksum="AA269668732BF817" modified="2021-04-07" version="1" fragment="single">MPAGTVDPGKAGKYATTTGEYSLASVKIPGLPAPVEMRGVVVAPKKAPGKRPVALFLHGRHSTCYVPGKDGEVSGDWPCAKGSKPIPSHRGYLRDQKLLASQGYVTVSISANGINGQDWNAEDGGAQARSSLIRNHLGRWADWAAKPSSAPAAVRKGPKTDLSKVLLVGHSRGGEGVNRAVMDSLYKPPAAQDGYRSKARWNIRGTVHIGPTIFGQNPVPDVPSLTILPGCDGDVSDLQGQVFTDGTRGVSRGKALHSSVYMIGANHNYFNTEWTPGQAQAPADDDFWHDPEARDPLCSPGAAGRLSANQQHKAGATYIAAAARLFVGGDDRVRQLVDGTGRRAPSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKV0</accession>
    <name>A0A7K2ZKV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001298">
        <property type="protein sequence ID" value="MYW32958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13545">
        <property type="entry name" value="PBP2_TbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029744108" evidence="1">
        <location>
            <begin position="32"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="366" mass="38986" checksum="A6C33E5A13998FCC" modified="2021-04-07" version="1">MNTTKKYASTALVAALGVTVLAGCGGSDDTSAGSGASKGSGSKTVTLVTHDSFNASEDVLKQFTKESGYTVELLKSGDAGAALNQEILTKGSPRGDVFFGVDNTLLSRALDNGLFTAYEAKGLDRVAKGTEQDDEHRVTPVDTGDICVNYDKKFFADKKLAPPQTFEDLLKPAYKNLLVTENAANSSPGLGFLLGTIASQGEDGYQDYWKKLKANGVKVVDGWEQAYNEEFSGSAGGKKAKADRPLAVSYASSPPVEVLYADPQPKEAPTGVSTGTCFRQTEYAGLLKGARNEAGGKALLDFLISKTFQEDVPLNMFVNPVVTDAKLPEIFTEFGETVEKPATVAPDKIAANREQWVQAWHSIAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKZ8</accession>
    <name>A0A7K2ZKZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001303">
        <property type="protein sequence ID" value="MYW33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="545" mass="57739" checksum="1B192D132FF4910A" modified="2021-04-07" version="1">MTETARRDSAPGTILVIDDDETNRYVLTSWLRRAGHTVLDAADGARGLALIGAPDTPQPEAAVIDVQLPDMTGFEVCERIKADPSTASLPVIHVSAVAMSAEDHTEGLSRGADAYLDQPVDPEEFLATVTAALRYVRARRRAERLTLRLAALNRATLDVYRAVGFHSFAAAATGGAAALMSCPATAIFLSPKGQPVHSHAAGPGAAPRSSPARSGLLDRLASYTLGSDTGAEVRVMPHSQWKALLPLDPIEGDVVLVVARTKRNRPPVCVAVPAGAAGGTDERELLQQLVNACALALEALRTFNEEHALALALQRTFLPDRLPSVPGVSLAVRYLPASDHAEIGGDFYEALETPDGLLLAIGDVAGHSLVAATVMGEIRHALRAYALEGHPPHHVLERLDALLAHTRPGLTVTLCLVLVDPDGSRIRVANAGHIPPLLLSPDGTAAYLHEHGPLLGLRLPHPPARVHPVAPGTRVLLITDGLVEVRTQNLDDSLAAFRSATLEGPRELEALCDALLGSFGEDKEDDIALLALQLDDVPDPSHRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL09</accession>
    <name>A0A7K2ZL09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001306">
        <property type="protein sequence ID" value="MYW33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="270" mass="28036" checksum="721635FE6C86DFF0" modified="2021-04-07" version="1">MADEPANTVLYDVSEGLATITINRPDAMNAMNTAAKVALRDSLRAAAADTAIRAVLLTATGRAFCVGQDLKEHVATLTATREAGDGNALSTVQEHYNPIVRAITEMPKPVVAGVNGVAAGAGFGFALAADYRVVAETASFNTSFAGVALTADSGVSWTLPRLIGPSRAADLLFFPRSISAQDALELGLVNRVVPADRLAEEAAAVARALADGPTVAYAALKESLAYGAGHTLAETLEKEDELQTRAGASQDHTIAVEAFLAKEKPVYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLP5</accession>
    <name>A0A7K2ZLP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent RecD-like DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recD2</name>
        <name evidence="3" type="ORF">GT040_29225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecD family. RecD-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001356">
        <property type="protein sequence ID" value="MYW33238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01488">
        <property type="entry name" value="RecD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006345">
        <property type="entry name" value="DNA_helicase_RecD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029493">
        <property type="entry name" value="RecD-like_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041451">
        <property type="entry name" value="RecD-like_SH13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14490">
        <property type="entry name" value="HHH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18335">
        <property type="entry name" value="SH3_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01448">
        <property type="entry name" value="recD_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="349"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="360"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="741" mass="79931" checksum="C40315CAF1A6067F" modified="2021-04-07" version="1">MSNMAVIEGVLERITYANEENGYTVARVDTGRGAGDLLTVVGALLGAQVGESLRMEGRWGSHSQYGKQFTVENYTTVLPATIQGIRRYLGSGLIKGIGPVMADRITTHFGVDTLDIIENAPKRLVEVPGLGPKRTKMIAAAWEEQKAIKEVMVFLQGVGVSTSIAVRIYKKYEDASISVVRNQPYRLAADVWGIGFLTADRIAQAVGIPHDSPERVKAGLQYALSQSSDQGHCYLPEERLIADGVKLLQVDTGLVIECLAELAADPEGVVREKVPSPEGGEPITAVYLVPFHRAELSLAGQVRRLLRTDEDRMAAFQDVDWEKALAWLATRTGASLAPEQEEAVRLALSRKVAVLTGGPGCGKSFTVRSIVELARAKRAKVVLAAPTGRAAKRLAELTGAEASTVHRLLELKPGGDAAYDRDRPLDADLVVVDEASMLDLLLANKLVKAVAPGAHLLLVGDVDQLPSVGAGEVLSDLLAEGSPVPAVRLTRIFRQAQQSGVVTNAHRINAGQPPLTEGLSDFFLFVEDETADAGKLAVDVAARRIPAKFGLDPRRDVQVLAPMHRGPAGAGELNGLLQQSITPGRPDLPEKRFGGRVFRVGDKVTQIRNNYDKGENGVFNGTVGVVTGLDLDEQRLTVRTDEDEEIGYDFDELDELAHAYAMTIHRSQGSEYPAVVIPVTNSAWMMLQRNLLYTAVTRAKKLVVLVGSRKAIGQAVRTVSAGRRCTALDFRLRGGSGEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM27</accession>
    <name>A0A7K2ZM27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">GT040_29875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="9"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="709" mass="77631" checksum="3D5F3200E5CCC904" modified="2021-04-07" version="1">MATTSLDLAKVRNIGIMAHIDAGKTTTTERILFYTGVSYKIGEVHDGAATMDWMEQEQERGITITSAATTCHWPLNDVDHTINIIDTPGHVDFTVEVERSLRVLDGAVTVFDGVAGVEPQSETVWRQADRYGVPRICFVNKLDRTGADFFRCVQMIIDRLGATPIVMQLPIGAEADFTGVVDLVSMKAFVYPEEAAKGEMYNVVDIPENLQESAAEWRGKLLEAVAENDDAMMELYLEGNEPTQEQLHEAIRRITLASKGSADSVTVTPVFCGTAFKNKGVQPLLDAVVRYLPSPLDVEAIEGHDVKDPEKVISRKPSDDEPFSGLAFKIASDPHLGKLTFVRIYSGRLEAGTAVLNSVKGKKERIGKIYRMHANKREEIASVGAGDIIAVMGLKQTTTGETLCDDKNPVILESMDFPAPVIQVAIEPKSKGDQEKLGVAIQRLSEEDPSFQVHSDEETGQTIIGGMGELHLEVLVDRMKREFRVEANVGKPQVAYRETIRKAVERIDYTHKKQTGGTGQFAKVQIALEPIEGGDASYEFVNKVTGGRIPREYIPSVDAGAQEAMQFGILAGYEMVGVRVTLLDGGYHEVDSSELAFKIAGSQAFKEGARKASPVLLEPMMAVEVTTPEDYMGDVIGDLNSRRGQIQAMEERSGARVVKGLVPLSEMFGYVGDLRSKTSGRASYSMQFDSYAEVPRNVAEEIIAKAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZML3</accession>
    <name>A0A7K2ZML3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029800993" evidence="2">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6589" checksum="2479CC5B7A5BF9C7" modified="2021-04-07" version="1">MKKLLLIAAALVLLILFPDLAQAVATVLAATVQFIAAQPVLIGFGLGVATIAHLRGKNPATARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMP0</accession>
    <name>A0A7K2ZMP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7780" checksum="E6D1C960B02E66C4" modified="2021-04-07" version="1">MGTRKPRKPWRVIITGPDVNATSDHTSEAKAYALVRAALGGDSPAGQARVEYWEGGRWWHFETVDADEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMX2</accession>
    <name>A0A7K2ZMX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="112" mass="11818" checksum="C51FFD87A8BDF154" modified="2021-04-07" version="1">MIASNRTRRATLKARQLANRAAARIRRNGTGTLATHCLAVGLTPREAKSVAGSLRKNAEKAGVVGTAGRSFRKGAARVCTRYTRAAVALIAAIYRPRKATYKVAAAKLALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN82</accession>
    <name>A0A7K2ZN82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001447">
        <property type="protein sequence ID" value="MYW33719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="250" mass="26924" checksum="1B633F99B876952F" modified="2021-04-07" version="1">GERDLLDELGRRNAEHTARERPAALAVPSVPAAAALADRYLPPLPAPLPVPTYPGQPPSYPDLPGARDPLGLDHLATDAAARAHALLTTGRDPFAGLTPWQDAVRIAASRPTAGLTATTRALYRELAHATGRNTTDLARAVAAWRQGGAEGLTVLETPWDPPAGPFDRARPLLAAAEFPRFTPWRNHLTHPTGTLQLRFGHDARWYGYESDPGADDWWPRATPDPDPVAALEALLTGDTVTEAPDDTYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN95</accession>
    <name>A0A7K2ZN95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1287" mass="142747" checksum="38EBA9DFF19D8195" modified="2021-04-07" version="1">MQYQQDHHVGGDAALHTDPWIQAAAHSTVWDHVPPTRDLAAFQNHVIGVVEKLTMLRDGSHADLASDPWQDPGMAVRFAERVEWLLGEPNATAPLDLYAAEAALLVLAPFLYAANSMRVAARYASVNPEILENDAHAGADRVSFEAFVEGHSLLVNRTVLRPEAAVPVGWWIFHRWLLHRGLHADGHGVQELIGLLGEHGRALGEVLSPDRLIGLLHGVRRGPDVTNHEFLERLPSDDRVRALGHQRIRDQRVALITALAYGTCADMATMPDIVAEHLGIPRPVDLDRLRETLEHATWGGQPFFPVLRADCHHEAVIEALRAHVARADDILHRVHRTARERLTHPMPVLPTRLSADNVRPANGIFDGWASFRLDERRVREMLMGVQLYKDQNLAVRELYQNALDACRYRRARTEYLDRTEPMSYSYEGRITFEQASDANGRLYLECGDNGIGMGDAELRGVFSQAGARFADQPDFKLERTSWGRLDPPVELFPNSRFGIGVLSYFMLADELTVTTCRMGLDGRPGPVLEASIHGAGHLFRIAKTAEQGTEPGTRIRLYLREAPTAEERWSSIDVLDQLLGIAEFPTSVRDGGRHKAWEVGRLHSREKPSRERFGLNAHGDQVDWSEAPPGVQVTWTEHGGGLLVDGLVVQPTHRKGVLSSSQSGLTGVVVNLTGAYAPARLSADRAQVLDDVSPLLRSLLIEASKSLASQEESLPKLTWINRIAYESPDLADLLTISLLKTGRQLTDGVRKLDIRATGIFPSDAENKIIRRSNSDRRESLWRTVGDPPNHIYLWRIIAHSDQRILSQLSTFCPEIIKSSPTLTALPSDQLLLSAMDDDRDYWHWTGGSYRSQTEYFLSAIEKFDLPPRQAASRAARLGIHDLRSEGFPDQRIELTRILPLLSESLDHQRSFISRSTQPGVQLLATKAAQTDLSPREVASFWHGLGIKVSDEVVALAEAIPNEPLLLRDGETTGAGFFDPGNTVPLGRIAQAAVELDLSVTEICDRYRSYGLRAEPGRLAGGANPEIVKLLRDHCAHQQSWLVAENPMPPAQVLIAAHELEVTPAAALRKYHDLGIEGPAQFPSDATMGDLSIFESPDEDHSVWVAPGPIPYQLILDAVQKDRPIRDVITRLRKYGFTVPMVAPETPDELDAQLLSTLSPCSWWDVYTGDSMPYAHVLAAARATFNSPQTIARRIESYGIPLSCTSLPPGLSSTRAHELLSFGQEEGMYLSKESYLPLQDLLERAAHCRVPLAQAVDWLTQLGLSVPNLGNTIREALTRLPRPQAPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNA4</accession>
    <name>A0A7K2ZNA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_32390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241463.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001485.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016795">
        <property type="entry name" value="UCP021697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021697">
        <property type="entry name" value="UCP021697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="42"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="155" mass="16561" checksum="E0AC2BE218B18E6B" modified="2021-04-07" version="1">MDNRQAIGSWLSGPRAAAEDMGADFGYRGKRLGLPEEGPGAVASFGRRLGAVFIDWSICMVIAYGLLARGDQQAAGNWALGVFLLMSALTVGTIGCTPGKRLLGLRVVSEDGGRLGFGRVLVRTVLLLLVIPALVWDRDGRGLHDRLGRAVQVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZND9</accession>
    <name>A0A7K2ZND9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_32060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001463">
        <property type="protein sequence ID" value="MYW33779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="188" mass="19569" checksum="78E7EEA78B8D1EB6" modified="2021-04-07" version="1">MLAGELYLADDPEIAADALRSALLNERFNATSAGDPEARRAALAELLGELGEGAEIRPPLRVDYGHRITVGPRTFVNFGAVFLDVARITIGADVQMGPNVQLLTPTHPIDPEPRRAKWEAAQPITIGDNVWLGGGAIVCPGVSIGENTVVGAGAVVTKDLPANVVAVGNPARVIRKIGEGAEEGPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNG1</accession>
    <name>A0A7K2ZNG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001478">
        <property type="protein sequence ID" value="MYW33799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029608695" evidence="2">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="7638" checksum="85E07AEB9060BCDC" modified="2021-04-07" version="1" fragment="single">LVLPVLLGVLGLLAGALSSTGPVASACGTQLLVAAVIGAGMPLPEPGGERALLFLAGAGWALVLRLVLPSRRRTSGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNT4</accession>
    <name>A0A7K2ZNT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nicotinamide riboside transporter PnuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_32890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001500">
        <property type="protein sequence ID" value="MYW33938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01528">
        <property type="entry name" value="NMN_trans_PnuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="23954" checksum="0ABA28A0A47709EE" modified="2021-04-07" version="1">MSLADILDPLQQPLVTVLGTPVSWTEVLGFGSGALCVWLVARQHIANWPIGIANNVFFILLFAQAGLYADAGLQIVFITLAAYGWWTWTHGGGPGTSVLPVRRTTRTEWAWLFTAGVVGTAGLTLLLTRATDSTVPFWDALTTSLSLMATYGQCRKRLESWWLWIAADVVYIPLYAHKGLYLTSLLYAGFLALCLAGLRSWHRDLTARNSRPLEAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP16</accession>
    <name>A0A7K2ZP16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001545">
        <property type="protein sequence ID" value="MYW34114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="14960" checksum="386D5045B61C3C18" modified="2021-04-07" version="1">MLAQPGGDRPWWWVEPRGGADGGGVGGGGDLKHSDGPWVRAAGGAEGLVAHFGPVKAELVRAHQGLTAGAGELSALAELGTVRASWERRIETARDECRSLAGKLRAVTATQSEVNEAVKGSFDGVRVVGPGSGPGLGPGAGAGAASGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPA0</accession>
    <name>A0A7K2ZPA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001552">
        <property type="protein sequence ID" value="MYW34173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="16978" checksum="42598DC1747F836C" modified="2021-04-07" version="1">RDAQRDEADLSYVRRLVQGRIDILRAELARRRDPRAPVPETPVVDRLSEILADAPSRHRTSARHVTLTTPRGDEFRRLAAENLAEVELSDLAARTDEELHDAMGRLVRYEQQVSRRRHELQRTTDDCSAEIARRYRDGEARVDDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPT1</accession>
    <name>A0A7K2ZPT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_35030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001598">
        <property type="protein sequence ID" value="MYW34352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="252" mass="27146" checksum="C7AAD3E485FFBF1C" modified="2021-04-07" version="1">MSSDDTSPSPARETSPSPFHHGPTDRDAAPQYVLPLVVHLEKTAPPARTDALRTAARAVLTILADERSTGEGEWAGVMRDWEDARIRKVVRRARGAEWRKAAALPGITVTGGSAEVRVYPPIPLDGWPKELAKLQVSGTDLDDPEPPAAPDPEGPVLWLNPELEMSAGKTMAQVGHGAQLAWWELGDTERKAWREAGFPLSVATATPERWRELTASGLPVVRDAGFTEIAPGPTVVAEGHHRVGSLPPAQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPV5</accession>
    <name>A0A7K2ZPV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001600">
        <property type="protein sequence ID" value="MYW34357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="91" mass="9463" checksum="C6A17618E44E4E64" modified="2021-04-07" version="1" fragment="single">MTDSWATFGADLHLEPVGSTGLRSGLMEALREAVRGGRLAPGTRLPSSRALAADLGIARNTVADAYAELVAEGWLTARQGSGTRVAQRSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ39</accession>
    <name>A0A7K2ZQ39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001606">
        <property type="protein sequence ID" value="MYW34379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7087" checksum="E1791BC7610F5472" modified="2021-04-07" version="1">MKTESPRWFTSSYSDNGGNCVEVAVNLAPSQGIVPVRDSKVVDGPVVGVRAAAFSAFVAGVRAGTFNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ99</accession>
    <name>A0A7K2ZQ99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pyk</name>
        <name evidence="17" type="ORF">GT040_35490</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="WWKE01001623">
        <property type="protein sequence ID" value="MYW34439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="358"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="479" mass="51688" checksum="79279E9F56534BE4" modified="2021-04-07" version="1">MRRAKIVCTLGPATDTYDQIKALVEAGMDIARFNLSHGSYAEHEQRYHHVRKAAEETGRSVGILADLQGPKIRLGRFREGPVLLERGDTFTITVEPLENQGNGDICGTTYDGLAADVTTGERILVDDGRVTLEVTDVDGPRVHTTVIEGGMVSDNKGLNLPGVAVSVPALSEKDIDDLRWALRTGADLIALSFVRTGRDIDDVHRIMDEEGRRLPVIAKVEKPQAVENIDDIVAAFDGIMVARGDLGVEMPLEQVPIVQKRAIKLAKRNAKPVIVATQMLDSMIDNSRPTRAEASDVANAIIDGTDAVMLSGETSVGKYPIETVRTMSRIVEAAEEDILAKGLPPLTERNKPRTQGGAVARAAAEMGDFLGAKFLVAFTQSGDTVKRLSRYRSPIPLLAFTPDEATRAQLNLTWGVETFLGPHVESTDAMVAQVDEELLRIGRCAKGDIVVITAGSPPGVSGSTNLVRVHHVGEDDSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQK4</accession>
    <name>A0A7K2ZQK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sel1 repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001669">
        <property type="protein sequence ID" value="MYW34646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="143" mass="15464" checksum="F325F26289745F32" modified="2021-04-07" version="1" fragment="single">AARGEQQTAERWYRAAMDAGDVNGAYNLGLLCAAQDRTPQAEQWYRRAAYAGHREAANALAVLLLQAGDHTGAEPWFSKAAEAGSVDAAFNLGILHAGRDEDRTALGWYERAAAAGHTDAALQVAMALLRDGEDREAERHLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQS4</accession>
    <name>A0A7K2ZQS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold shock domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="8125" checksum="9A4A860EA1906058" modified="2021-04-07" version="1">MVTATVREWNDEEGWGVLDSAETPGGCFGHYSNIRASGFRTLSAGQRVDLTWEAPGFQQDGYDYRALSIVPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRF0</accession>
    <name>A0A7K2ZRF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Siderophore-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001710">
        <property type="protein sequence ID" value="MYW34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="23131" checksum="FF1E46E651FBCF4F" modified="2021-04-07" version="1" fragment="single">DAVADAPGLSAEALATRLGVSGPGIGVLLPLLSSYGVVVGADDGAPGLRLGPAGEELLDEHEREEYTGHEAELLLALTHLAPALRGGGSPWRLASGDTLHESVAQDAERYGELVEECEQLVFLLGGLTADPLWESVGTCLLTGPGSASVAAALDDAGRRPRLRVAEDAVPVAVLRGHVPAPDRIDWTGGPADVAVAAKALAHRTDEEAALLLTRLAGWARTAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRJ5</accession>
    <name>A0A7K2ZRJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lantipeptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001701">
        <property type="protein sequence ID" value="MYW34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="21251" checksum="2591D854A285265B" modified="2021-04-07" version="1">ALLLVRRYETTGDPALLDLAAAALRRDLDRCRAGDDGELLVVEGKRLMPYLGAGSAGIAAVIDAYLVHRPDPELEAKGRALLPAALSAFYVQPGLLRGSAGLLMHLAATPLCDEETRQRAIRLHTRLLAGHALAYEGGLAFAGEQLMRMSMDLATGTAGCLLALGSALDTAPGPPTTLPFLAAAPRAAHPGRASGPTDRLLQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRK1</accession>
    <name>A0A7K2ZRK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001735">
        <property type="protein sequence ID" value="MYW34976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="18207" checksum="07E52C902E994A42" modified="2021-04-07" version="1" fragment="single">MTTILVTGATGTLGRQVAERLRTEGADVRGLSRRSPSYAVDLRDGKGLDAAVDGVDAIVHCASSPRGGDDRAAGFLIEAARRAGVPHLVYISIVGVDRVPLRYYAAKRRVERMIEDSGVGATIQRTTQFHDLVLSVVSGAAKLPVLPVPAGVSVQPVDSGEVADRLAALALGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRU6</accession>
    <name>A0A7K2ZRU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteinase inhibitor I36 SMPI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001732">
        <property type="protein sequence ID" value="MYW34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029567505" evidence="1">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14775" checksum="C3CF475CE94DDD90" modified="2021-04-07" version="1">MRTNRTTVLVAALAVTALTALIPQALAQDRSPARVQPASDVRLGTCEAGRLCLWKKPDFTGARQTYELSTVDIESCTPLPKGGDAQSLANRTGRPVTTYQSAECRETGEFETYPGGGTWLPRSPYQVRAFKIWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRZ7</accession>
    <name>A0A7K2ZRZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001770">
        <property type="protein sequence ID" value="MYW35077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="590" mass="63901" checksum="0D4A606531D7EBE5" modified="2021-04-07" version="1">MNLPGARERRVRTGGVELCVAELGDGDHPTVVLVHGYPDSKEVWSEVAVRLAEEWHVVLYDVRGHGRSTPPKPLRGGFTLEKLTDDFLAVIDAVSPDRPVHVVGHDWGSVQSWEFVTVGRTEGRIASFTSMSGPSLDHFGHWIKQRMTRPTPRRVGQLLGQGAKSWYVYMLHTPVLPELAWRGPLGKRWPGILQRLEKVPAGDYPTASLPDDAAHGAWLYRDNVRARLGRPRADAYAHAPVQLITPTGDSFLSERLYDDLEQWVPRLVRRSLPAKHWVPRTRPDQLAAWIGEFAAAHEAGGQEGTPVQQPAAKGRYAERFGGQLVLVTGAASGIGRATAFAFAEAGARVVAVDLDAEGAARTAELARLVGAPAAWGEAVDVSDEAAMEKLAAKVAAEYGTVDVLVNNAGIGLSGSFLETTSEEWKRVLDVNLWGVIHGCRIFGQQMADRGQGGHIVNTASAAAFQPSRALPAYSTSKAAVLMLSECLRAELAEKSIGVSAICPGIVNTNITATSRFAGADAAEEQRLRKRATRLYGRRNYPPEKVADAVLDAVVRNRAVVPVTPEARGARLLSRVSPGALRRLARLKPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS67</accession>
    <name>A0A7K2ZS67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_39195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001780">
        <property type="protein sequence ID" value="MYW35147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="165"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="25772" checksum="FA5D68F1FF28E639" modified="2021-04-07" version="1">MNTPASPTPSASPPVRLLIVDDDPLVRAGLTLMLGGADDIDIVGEGADGSEVAALVERLRPDVVLMDIRMPGMDGLTATAELRRRPGAPEVVVLTTFHADEQVLRAIRSGAAGFVLKDTPPAEIVDSVRRVAAGDPVLSPAVTRQLMARAAGGAPDDRTSRTERARRRFAELAERERAVAVAVGRGHSNAEIAGELYLSVATVKTQVSRILAKLDLNNRVQIALLVHDAGLLDTDDKESDGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS73</accession>
    <name>A0A7K2ZS73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001786">
        <property type="protein sequence ID" value="MYW35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="11935" checksum="94A77BB2F49AF986" modified="2021-04-07" version="1" fragment="single">MSLLELIGRADERALAASAVACLDRCLPLLAGPDGPEPLRPLWASCEDGREWAIRLAAVRTAMDDEAVSDGPAARVRAMLGAAPSGFDPAPLREWADACSLVALEIHGRFDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSB6</accession>
    <name>A0A7K2ZSB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_39615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001798">
        <property type="protein sequence ID" value="MYW35222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="23"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="14239" checksum="9DCA4016ED7E610F" modified="2021-04-07" version="1">PDRAVTGTHADRSAPRASVAAPNSRAARAVSFAHGAIGKPYVWGATGPNAFDCSGLTQAAWKAAGVSLPRTTYTQINAGQRVSRSELAPGDLVFFYSGISHVGLYIGGGQMIHAPRPGAPVRIAPIDQMPFAGATRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSG7</accession>
    <name>A0A7K2ZSG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001820">
        <property type="protein sequence ID" value="MYW35247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="9511" checksum="09D6D4A87B601F18" modified="2021-04-07" version="1" fragment="single">AGAGGPGRAGPGGRSPSRSHPRSRSRSRERRRRRNRRRTAGLAVLVLAAVALVALLVDRPWRNGDPSVTADAGPTTGTGDDDAETPVAPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSH6</accession>
    <name>A0A7K2ZSH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001835">
        <property type="protein sequence ID" value="MYW35340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029897744" evidence="2">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="14253" checksum="A26A03E500AAE138" modified="2021-04-07" version="1" fragment="single">MKIRRILATAVAVAVTTPAVMLSVTPAFADTKPAAQTPAKPTVKELEKAVAEAEKAYDAAVAAERAAYDAVEAAVSDTAPLTVAAKAARKAADEAAAAKTTADKAVTDAQAALDDLTEDEDATAEDKAAAEKALADAKTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSI9</accession>
    <name>A0A7K2ZSI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_40305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="12960" checksum="48E8B3775A9A463B" modified="2021-04-07" version="1">MFALRGDLDFHSVVQLYEAGEEELGTGRVAGAVVIDCAHLAYCDSTGISALLKLYHQMSAQDGVLCLASVTDNLNRLFELTGLKQIFCLHTDAEEALNAHLRVPGTVAAGADSAARSGTEHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSL7</accession>
    <name>A0A7K2ZSL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001833">
        <property type="protein sequence ID" value="MYW35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029862255" evidence="1">
        <location>
            <begin position="34"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="434" mass="45284" checksum="F0F3126236E48B45" modified="2021-04-07" version="1">MKLSARIAAPVAALVLAGLTATACAPQTSDTSAKGDEKSGTLRVWLFQEVGNKPKEKVVDDAVAAFEKSHEGAKVEVEYIPVDTRAQRIKAAFNDPKSAPDLIEYGNSDTAGYVKDGGLADVTEEFGAWEEAKDTDPIAKQSVTVGDKVYGAPFFVGVRALYYRTDVFKDLGVEPPKSQAELISTAKKIHKAKPDLYGLAVGGAYTYGAMPFIWSHGGEIAGESGGTYKSAINSEKARKGIEAYTSLFGDDNCPAAKCASMGGNATVTAFASGKAAMAIGGDFSHAAVEAGSVKGKYAVVPLPGIAPDSIAPAFAGGNNIGVLKSSSHRTLAVDLMKSLTGKKTQAEMFDAMGFLPTYTDVLDNAAKKQPFVAPFVQTLGAGAKFVPASPAWGQIDASLVLPNMFQEIVSGRKDVARASDDAAKKMDAAFTDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSM4</accession>
    <name>A0A7K2ZSM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001843">
        <property type="protein sequence ID" value="MYW35394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="112" mass="11835" checksum="E7B4C20CC87219A4" modified="2021-04-07" version="1">MTTAATVAGIWDLSIATPIGKITAVIELREEEGALSGTARGAGEEVRLDGLALSGDRLTWKQAVTRPMRLNLAFDVTVTGDSLAGTSRAGRLPASRVGGLRRTDRAESWGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5T9</accession>
    <name>A0A7K2Z5T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="65" mass="5921" checksum="EE6E206A226C07D9" modified="2021-04-07" version="1">MDVDPSVDVDVDVDVEVDEALVGASVVGGPPGAAVPVTPPSDPGTVLLGVGGSVGVPAGGGAGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5V6</accession>
    <name>A0A7K2Z5V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4177 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000003">
        <property type="protein sequence ID" value="MYW27726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003967454.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="63980884"/>
    <dbReference type="GeneID" id="66961046"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="52" mass="5964" checksum="C15DE60F0EE24CD1" modified="2021-04-07" version="1">MTKWEYATVPLLVHATKQILDTWGEDGWELVQVVPGPNNPEQLVAYLKREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5W6</accession>
    <name>A0A7K2Z5W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1206 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000004">
        <property type="protein sequence ID" value="MYW27736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="188"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="26730" checksum="C91D4FE5F5C67F8D" modified="2021-04-07" version="1">MEAGARAGFGARGVIYVLVGALALQIALSGGGGKQADRGGAIAEIAEKPFGKIVLWLLGIALVGMALWRLSEALFGSAGPDGGKASKRAMAAGRFVFYSFVAYSVLSFAAGDSGSGGGSSDQQSQDVTAKVLGWPGGQWIVGIGGVAIACAGIWIAVRAIMRKYHKHLKMAEMSQKVRRAVDFTGVFGGSARGAVFATAGGFAVAAAVKHNPDQSKGMDDTLRSFTQTPVGPWLLVVIALGLVAFGIFSWFNARYRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z747</accession>
    <name>A0A7K2Z747_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VII secretion integral membrane protein EccD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000111">
        <property type="protein sequence ID" value="MYW28176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="29158" checksum="541C76996D232E2C" modified="2021-04-07" version="1">CARIGAGNRGLATALLFVSGGLGVLTAWTAADAYDWSGPARLAAVAAAVVLALSLLGFFSPLGRGGLVGAGATAAVTAVWEAVAAVESDPARLGAVMAVFSVVLLGMLPRLALMASGLTALDDRRSGGVSVSRHDVSNALAATHRGLALATVVTAVSATAAGWLLTLSARPTVWTVLLPSVVAVVLLSRARAFPLVAEVVALFAAAAVLIVRLVMLWMEQASGGSGPVLLLGVAALLPLLALSVEPPEHVRVRLRRTADLVESIGMVGLFPLAIGVFGMYGQLLNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z751</accession>
    <name>A0A7K2Z751_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_02510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000109">
        <property type="protein sequence ID" value="MYW28171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="198"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="333" mass="34436" checksum="63D29C67519AC305" modified="2021-04-07" version="1">MTAGNNGASKPEDDDPFGYLYADGQAAGAQPPGQGGYGYPGPAAQPGVPRTSYNQVRTVGERQYGQHQVPPQQGYGYPPQQAYGQPAQQYNAPNPQYAAPETYPGGATTAQHGSVPGGGPGGGSGGRGGPNTKALLIAAVAVVAVVLIGIGAALLSGSDGDKDKKNEAVSSEGPADKAEESGKPEKKPEDTAKPVELPKQDAATLTLGGPATVDSSVEGAQGVNGTYVTGFNEVGSSVTWRADMKSEGSYRLSVRYAVPAKDANATLTVNGKKNTQPIGLKNFIKSSDTALEKNWQTTWAPVDLKKGENEIKISCEDGNQCDVLLDWLEVTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z799</accession>
    <name>A0A7K2Z799_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000119">
        <property type="protein sequence ID" value="MYW28229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514655.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000119.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8463" checksum="4BF0FE2F1B425797" modified="2021-04-07" version="1">MSTSEEISALLVAKFGTDPEALGPDVPLHRLRLDSLALEELRLLIEDRLDVDLEDVALTSRDTLGRLIEVVHVKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7A5</accession>
    <name>A0A7K2Z7A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_02850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000123">
        <property type="protein sequence ID" value="MYW28237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="18858" checksum="405E13D523715FD0" modified="2021-04-07" version="1">MIWYTALVLGVAAERLAELVVARRNTRWSLARGSTEAGGGHYPAMVVLHTALLAGCLAEVHQAGRPFLPVLGWTMAAVVVAAQALRWWCITTLGPRWNTRVIVVPGLPLVTGGPYRWLRHPNYVAVAAEGIALPLVHGAWVTAAAFTLLNAVLMAVRIRCEDEALARLPVAEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7M1</accession>
    <name>A0A7K2Z7M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12258" checksum="EDC09F9FB9664F60" modified="2021-04-07" version="1">MADRGVHEGAGGAVSDATNAVLVEIATERAAQDAIFGQQDLPDGTGITGDADRASSARHVCDVMFERGEGTYRDVFYEEVCEAFAESDPVKLRAELVQAVAVGVKWIEAIDRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7T2</accession>
    <name>A0A7K2Z7T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_03535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000148">
        <property type="protein sequence ID" value="MYW28368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15476" checksum="416E0908DCD4AFF4" modified="2021-04-07" version="1">MSGAYGRVLVVDDNKVIRQLIRVNLELEGFEVVTAADGVECLDLVHRIRPDVITLDVVMPRLGGLEAASALRSDTRTRHVPIVVISACTPYEVDAGVSAGVDAFLAKPFEPSELVRMVHRLATREDRPPVDGRSGAGRAGSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7W3</accession>
    <name>A0A7K2Z7W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000170">
        <property type="protein sequence ID" value="MYW28449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16133" checksum="B8DF0AD0895BEB24" modified="2021-04-07" version="1">SGAIGPSVPLAAAATSLRWAETAVQLIKKNLLPQGEVLHCTERTEELVLLPSRELIDAAARRCLAPMDGLGPTAAKRLAETLLAWIETPGGAPEVAQRLGIHPQTARYRLRQIRELWGDAIDDPDQRFEMLLVLRSQRLRGALAQGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8I0</accession>
    <name>A0A7K2Z8I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000211">
        <property type="protein sequence ID" value="MYW28605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="392" mass="41327" checksum="617FB2ACC0D864BA" modified="2021-04-07" version="1">MVGGSIAGCAAAVAGSRAGADVTVYERSGAELQDRGFGIVIPPSLHRELVASGYLDARMETAPVSTRVWLTREPGGRSTRELARQSSPVTPCNWGLLWRSLRASAGAVRYLRGEPVTSVGEGPDGRAVVTTARGEERYDIVVGADGHASRTRQLLAPGLTPEPAGYPVRRGAIPLSAPADHPRELELLRGAWVTIGFPGGHGIFYLIPGGSRHPGAGDRLLAYAIYGRPPASPDADADPGPYVRELAKEHFPAGWAEIVGHGTHRTTACHPVADAQVPRAARAPLLLAGDAAGVSRPHTASGAVKALQDALCLERVLRDGPTVGAALERYADERTAAGAHLVELGRRMGRAQVEETPDWAAMGQEEVDVWFRGVLAGTRHYLYEQPGAGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8L1</accession>
    <name>A0A7K2Z8L1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000245">
        <property type="protein sequence ID" value="MYW28686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="489" mass="50935" checksum="BAC2D7C4A6DB9495" modified="2021-04-07" version="1">MAGQAVPAGGQPWGQPWGPQSDAPAQPGAQAPGAYGYPQQQAQPLPPAQGQGQQQYGQSQGQEPGYDPSYGHGGAGAYQQPQQSQQPQQPQHSDPYQQQHQHQQYPSQQYQPQQSQQSQPYAQPLPPEAGSGAGQGVPGGDADATQYIAPVPSGGGDADATQYIPPVPGGAPYGIRPGAPGAPDDRQPPAEFDNLFRAEGPAGATQQMPHQQYNQQHQQQPPQAPSQPQPQHGYGYPGPGSQLPPQAPQGAYQSGLQGLRGGDGAAGPPPYDGGDEAPRKRSAHIPLIAAVVVGCAVIGLGAGALLSGGDEPGKDDKQPVASQSSPVTTPTTEAAADPGKPQAEALDKLLADSNNSRAAVISAVEKIKSCKDLDQANTDLKGAAQQRRDLVTRLEGLTLDQLPQHEALNSSLTRAWKASAAADDHYATWARQAKKNKSVCKGGQARSTNETARANQQSGEATKAKQEASKLWNAIAGKYGLTKHTPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Z9</accession>
    <name>A0A7K2Z8Z9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000259">
        <property type="protein sequence ID" value="MYW28824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="400"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="443" mass="48299" checksum="92F5D23101B69928" modified="2021-04-07" version="1">GRTPSIWDTFSHTPGKVQNGDTGDVAADHFHRYRDDVALMKRLGLKAYRFSVSWSRVQPTGRGPAVERGLDFYRSLVDELLEAGITPVATLYHWDLPQELEDAGGWPERATAERFAEYAAIMARALGDRVGMWTTLNEPWCTAFLGYGSGVHAPGRTEPAAALRAAHHLNLAHGRATEALRTHLPAAAQTSVTLNLHQVRPLTGSEADADAARRIDAVGNRIFTGPMLHGAYPEDLLADTERIVNWPELIHDGDLAAIAAPIDVLGVNYYTPTIVSTPASGAGDTRNDGHGSSDHSPWPGSEHVAFHLAEGKPVTAMNWSVDPNGLHALLMDVARENPGLPLMVTENGAAFEDAVDADGQVHDPERIAYLHGHLAAVQRAVADGADVRGYFLWSLMDNFEWGYGYAKRFGAVHIDYATQRRTPKASAHWYSEVIERHGLPPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z991</accession>
    <name>A0A7K2Z991_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_06490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000299">
        <property type="protein sequence ID" value="MYW28930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="26670" checksum="164DAF3F2AD8E112" modified="2021-04-07" version="1">LGLAGAVMQGMTRNPLADPGILGVNTGAACAVVAATVLFGTRSLQAVVWWALLGAAVAVVVVYLLGGRGAGRGTPEGLVLAGVAVTAVLGAVVSGLGVLDADAYGTLRMWSVGTLSGRELPVLWEVLPFLLAGAVLALTVAPALDAFALGDEAGRALGVAPGRVRLLGTLATVLLSGAATAAIGPVGFIGLVAPHVARLLTGPDHRRLMPYAILIGAGLLLVADIVGRVIARPAEIQVGIVTAFVGAPVLIWLIGRNRSASRKAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9E4</accession>
    <name>A0A7K2Z9E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000299">
        <property type="protein sequence ID" value="MYW28942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="46" mass="5231" checksum="703CD616A027C462" modified="2021-04-07" version="1" fragment="single">MDAAFTAEQDEIRRTLRDLLAKHSGPGEVRAAVRTAEGHDRALWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9M7</accession>
    <name>A0A7K2Z9M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000317">
        <property type="protein sequence ID" value="MYW29043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018516325.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000317.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="88" mass="9136" checksum="5B23A414F8AA7900" modified="2021-04-07" version="1">MGFLDNLKAKLGPAKEKVGDLAQQHGGKIEQGLDKAARTVDQKTKGKYSDKIDTGTRKAKEAVDKLGQKDGGTPGTPGTTPPPPPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAH6</accession>
    <name>A0A7K2ZAH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_08565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000402">
        <property type="protein sequence ID" value="MYW29328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="313" mass="34363" checksum="D10C6233DBCC230D" modified="2021-04-07" version="1">MTTHTLRSKRRRSALRNAAFMSPWLIGFSVFFAYPMVSTVYFSFTEYDGFGAPVFNGLTNWTYVFRDYPMFWPSLWNTLWLVVVMVTCRVVFGLGIGLLITKIKTGTGVFRTLFYLPYLAPPVAATLAFVFLLNPGTGPVNAILGDLGLPTPGWFNDAAWSKPALTMLAVWGIGDLMVIFMASLLDVPTEQYEAAELDGASAWQKFRFVTLPNIAPIVLFAVVTGVIQAMQYYTQPLVAGKVASGVIGGSGQSFEPGYPDKSTLTLPQLVYNLGFQRFDYGAACVVALILFALAMAFTALLMRGRNNLIQAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAQ1</accession>
    <name>A0A7K2ZAQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000418">
        <property type="protein sequence ID" value="MYW29451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="14336" checksum="573B38D51EDF4306" modified="2021-04-07" version="1">MASDTDDLAFDVFSRQCPSRSTLEHATGRWGSLTLGALYEESLRFNELRRRVDGVSEKMLSQTLHALERDGLVLREAQPVNPPRVDYELTPLGREVAGRLLGLIHLVEGRMDDVLAARTRYDAARGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAW7</accession>
    <name>A0A7K2ZAW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VII secretion system-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000431">
        <property type="protein sequence ID" value="MYW29496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="24251" checksum="39BE2AA0DEDD802E" modified="2021-04-07" version="1">MENPTGEPQEGPQGVPSALPAASPVPDASPVPDASLVPDAVKDAARRAPGHWIGIVDPEWTEERTPPEWAVLGEWQSDASGDVAEYRANPAYRPSARVLGWPEPTDPVDAAAQRAATGYGTVEGALAALAEADVSVVRGPDGGPLVAAGRDGAPVVLLFTSPTHEFMSAALHHDTLSARELARSVTAAGALLSVNPGAAAPLLVPADSLFGPLDPAPVAGAGGPHPTEPWPHTTGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB57</accession>
    <name>A0A7K2ZB57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein GT040_09990</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000459">
        <property type="protein sequence ID" value="MYW29597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514299.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000459.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="12687" checksum="C84A983D00934E3B" modified="2021-04-07" version="1">MGIEDFGGGQTAQADVLVVTTNDVPGYQVTQVIGEVFGLTVRSRHLGSQIGAGLKSMIGGELKGLTKTLVETRNQAMERLVEQARARGANAVLMMRFDVSEAADVGTEVCAYGTAAVISKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB68</accession>
    <name>A0A7K2ZB68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000460">
        <property type="protein sequence ID" value="MYW29607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030572695.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000460.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029771392" evidence="2">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="16076" checksum="182F862BDDC1785B" modified="2021-04-07" version="1">MRASRVLAVTVTAFAAVGLAAPMAAATNGPVNVAVNPQAVHQGGTLKITARGCGHGGTVWSNAFPTTSLSAGDGTNYAHARVRNNTTPGHYHLSVKCSDNDRIATHKFTVLAGNGAQGGLGGSMGPNSTEMQVGGGLVAAAAVGGAVFLVRRRRTSHAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB69</accession>
    <name>A0A7K2ZB69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000452">
        <property type="protein sequence ID" value="MYW29558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="437" mass="48759" checksum="1D17A945516A3A92" modified="2021-04-07" version="1">AVADGAAREIVERLSRERPTGAWQHALIRLATVWSADEELLDADPDLFDTLAGLSPVVPTELGLALAEPFRGVIELAHRWRRPAAHRGAWARALAHRKKLLAEEPAADRRSRLTEGIIALADDDAVRETMFPISVTRDVIHTATPDDADAIGTLMRQWARQGGLDARWTDRLVERWLVDDPASFQLIRDGGDRIIGLTNTQQVTERTVNCVEPLLQQHTDRLLDRPRGTGGWLLGAAYCPDRGAHAHLLRGLLRQVIMGGLLLTVSTPNPDYQRLLRGLRFQRHGTTADDVYRCGRKPEIFSQDFGSAALPDWTERLARTSGMRGGPRPTGQEVARALTGIADPARLAESPLLSSPRPRTVAELRADLWEAVRRLADSEVREEAEAGWILRHYYLGRPRTHQRLAQQLHISRATYFRRLRHGLDLVGGALAEERSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBI6</accession>
    <name>A0A7K2ZBI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="12662" checksum="51E847AB14B77557" modified="2021-04-07" version="1">MATVYRWRLAPDGLATRRQLRAQGLRPGGQDVVAELHRPRRRRGPLVAYLYRIEHARPVRPMTPGRAAALAAAMRARRTCPNCRTDVGYCIPRSLGMCVTCHDTPTPVPASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBK1</accession>
    <name>A0A7K2ZBK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000491">
        <property type="protein sequence ID" value="MYW29740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="19904" checksum="009C0878DBE8FE30" modified="2021-04-07" version="1">MDFEQLRAACEARVEALRLPHRFSTRDLRDAVAEQRGRPIILRPLSTLGALDAPCGIRLETPDADLLFYEEATSPLHQNHILAHEISHIICDHPGSLELDLDTLRAIGFDPTLVQRMSGRTSYTSEDEREAEVMASVIRQLMYRGREGPSRRPASGAESWDALFAEPHRKRRHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBP0</accession>
    <name>A0A7K2ZBP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgA</name>
        <name evidence="5" type="ORF">GT040_10910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000495">
        <property type="protein sequence ID" value="MYW29777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="190"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="387" mass="42070" checksum="C10E00F098FA1E31" modified="2021-04-07" version="1">MKVGLLSREYPPDVYGGAGVHVEFLARELRALTDLQVHSWGEGASDGLVRHRPGRELDGANDALRAFSVDLSIAAALEGRDLVHSHTWYANLAGHLAGLLYGVPHVVTAHSLEPLRPWKSEQLGGGYALSSWAERTAMESADAVIAVSHGMRADILGCYPQLDPDRVRVVHNGIDTRLYRPVPGADVLRRLGIDPDRPFVLFVGRITRQKGVPHLLRAAHRLDPSAQLVLCAGAPDTPDIEAEFRELVGELRRSRDGVHWIPDMLPRPDVIQLLSRAAVFVCPSVYEPLGIVNLEAMACGAAVVASAVGGIPEVVSDGGTGLLVPYEVDEPARFEADLAEAIGQVLADRPAARRMGEAGRERAVREFGWDMVARRTVEVYEETVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBY8</accession>
    <name>A0A7K2ZBY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000503">
        <property type="protein sequence ID" value="MYW29822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="249" mass="26002" checksum="7E08DB92C10C4A82" modified="2021-04-07" version="1">MTVSTAYSADAEGVCVVTVDHPPVNALPVRGWYELADAVRAAGRDPEVRCVVLTAAGRGFNAGVDIKELQRDPGNAALIAVNRGCAEAFEAVYACEVPVVAAVRGFCLGGGIGLVGNADAIVASEDAVFGLPELDRGALGAATHLARLVPQHLMRALYFTARTVTAAELLAHGSVWRVVPAAELLDVALELAAEIARKDGHLLRLAKAALNGIDPVDVRRSYRFEQGFTFEAGLAGTAGRVRDTFGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC33</accession>
    <name>A0A7K2ZC33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PBS lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000543">
        <property type="protein sequence ID" value="MYW29916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8208" checksum="E056CD3489E9C94D" modified="2021-04-07" version="1" fragment="single">ATPEVLRVLRGAPEYRGEWLRTAALRALGSFGPAAREAVPELRAMLRRPGTATEAAEALWAVAGDRDAVLPVLTEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC75</accession>
    <name>A0A7K2ZC75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000536">
        <property type="protein sequence ID" value="MYW29908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="158" mass="16501" checksum="E3D21CBA59340250" modified="2021-04-07" version="1">RVPGARLVLVGDGPDRAGLEAAAPAGVLFTGASADVRPWIHAADVVVLPSRWEGMALAPLEAMACGRAVVMSDVSGARESVAPGDEDHLLVPPEDPSALAASLTALLTDPELREAVSHRALRHARAAFDVRRTAGAVAGLYQQIVSLSGPTMRKRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC95</accession>
    <name>A0A7K2ZC95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000547">
        <property type="protein sequence ID" value="MYW29953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029821502" evidence="1">
        <location>
            <begin position="36"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="301" mass="32422" checksum="D1646FBA5970FE24" modified="2021-04-07" version="1">MEAPSAPPAPTRRRALTVTLAAAAAVIAAPAGVAAASPATVGRPSGARPLRHAHAHNDYLHPRPLHDALAHGFTSVEADIFLVDGELLVAHDPAGLDPGRTLAGLYLEPLRALARAGHGSVHPHHRRPLQLLIDIKADGVAAYRELDRQLTRHGSLFTRYHHGRVRPGAVTAVISGDRAARVPMEAQRTRLAFYDGRLDDLGTASPASFAPLISANWTQTFGWLGAGPFPRAERDRLRTLVRAAHREGRRIRFWATPDLPGPEREAVWSELLAAGADHLNTDDLAGLERFLRARTGVAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCA8</accession>
    <name>A0A7K2ZCA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_12010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="WWKE01000552">
        <property type="protein sequence ID" value="MYW29987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="187"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW29987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="34340" checksum="0B77BD61D20F8645" modified="2021-04-07" version="1">MQRWRGLEDIPQDWGRSVVTIGSYDGVHRGHQLIIGRAVERARELGVPSVVVTFDPHPSEVVRPGSHPPLLAPHHRRAELMAELGVDAVLILPFTAEFSKLSPADFIVKVLVDKLHAKAVIEGPNFRFGHKAAGNVALLTELGATYDYTVEVIDLFVTGEAGGGQPFSSTLTRRLVSEGDVAGAAEILGRPHRVEGIVVRGAQRGRELGFPTANVETLPHTAIPADGVYAGWLEVAGESMPAAISVGTNPQFDGTERTVEAYAIDRVGLDLYGLHVAVDFLAYVRGMLKFDTIDDLLVAMAGDVKRCSELIAAYDRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCB5</accession>
    <name>A0A7K2ZCB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000553">
        <property type="protein sequence ID" value="MYW29996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="13767" checksum="2ED686C50E6A36EF" modified="2021-04-07" version="1">GHAGLGVSFSHADGLAAAAVGPGPVGIDVEPLERRPGSLTVLRRLLPEAEVDAAGAEAEPGPALLRLWVRREALFKAGRDDARLTVWTDHRRAAVVALAGGGPSVCGPVDGALPAAAPRAGPSWASISQLEQFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCJ7</accession>
    <name>A0A7K2ZCJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000596">
        <property type="protein sequence ID" value="MYW30091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029553972" evidence="2">
        <location>
            <begin position="26"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="3">
        <location>
            <begin position="410"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="521" mass="56263" checksum="9F06698C0CE0433B" modified="2021-04-07" version="1">MRAVPLYATIGSLVLSALVAAPATASDGPAPASAEERGTTVAAVRAAAAGISFGACPEEEQLPDTLECGTVSVPLDYAEPDGRTIELTVSRALATGDAAGRQGSLVYNPGGPGASSVTFPLMGEMSEWKEIAEAYDMVGYAPRGVGASAPLSCQDPAAFAQSPTDSPVHPTAAYKEQRIAQARAYARGCEKHAGEALRHYTSLNNARDLEVVRAALGDERLTFMGASYGTYLGSLYATLFPSRVRRMVFDSAVDPDPEQIWYRSNLDQSLAFESRWEDFRRWVARHDDVYRLGTTPEAVQRHYDDVRTRLAAEPAGGKVGPGQFHAAFLQAGYYDDYWAMRATALSEYVRGNPEPLITQMSPRAITAKGDENARAVYTAIECNDAPWPEEWEVWDRDHSDLATVAPFQTWDNAFTNLPCAFWPAPRQQPLDVSTGWGELPPVLILAAERDAATPYKGALELQRRLRGAVLVTERDAGTHGIGGAGNTCVDDHLRRYLLTGATPDGDAECAPHAEPNPVSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCZ5</accession>
    <name>A0A7K2ZCZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000604">
        <property type="protein sequence ID" value="MYW30178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="353" mass="37318" checksum="D1E7EE04C0CDD01B" modified="2021-04-07" version="1" fragment="single">MAGDERSGLFQPLPGAAFLRASLAGAECRPALVLLEGGAGTGKTTLAARWARAAADRDARTLHHTPAAGSTAPPDLTAVEAPALLVVEDVHRAPDGTVPWLRAWLREARPGFVTVVSYRPAELPNPACPLGLDPELPPALRIRRERLGPWERDRTRALALEVLGPERSSERLADRLHLLAGGNPQTVRDLLDALAETTDAAAALQDAEVEPPVRLSQHITARMASLEEDATALVRAAAVLGGGSRERDLRRVAGLGRSAGGAGLVQALRSGLLEERAPDRYSFTIPLAASAVLTGLPGPIRCSLHRRAADVLTRGGEVSWVAVAHHERLGGREGAWLRAAERAADDPNALADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCZ9</accession>
    <name>A0A7K2ZCZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="16261" checksum="C90A6E8E4F7D7DE4" modified="2021-04-07" version="1">MSFSSLISRTKPKHRAVDAVANLRDENRRLLTQLFGARDHIAVQEQQLTDVRAKRAEAEQVVVCLAADLDERTTERDQAVAEVTALRAQLAPFLAAEANANAVTVPASVRDTTAFEDQATAPINVRPLWEAIGPVVRTEGSTDPAHLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDC7</accession>
    <name>A0A7K2ZDC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-6-phosphate dehydrogenase assembly protein OpcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">opcA</name>
        <name evidence="2" type="ORF">GT040_13795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000654">
        <property type="protein sequence ID" value="MYW30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="341" mass="36454" checksum="1D7E5EC49691C4CC" modified="2021-04-07" version="1">MKIDLTETTSSKINQALVSARRAIGTPAIGMVLTLVIVTDEENAYDALKSAGDASREHPSRIIAVIKRVSRSPRARRDARLDAEVRVGSDAGTGETVVLRLHGELANHAQSVVLPLLLPDAPVVVWWPEDAPADAAKDPLGALAQRRITDGYSAERPLDELAVRAATYSPGDTDLSWTRITPWRSMLAAALDQQPAQVIGVTVEGESDNPSCELLAMWLADRLAVPVERTYSGGPGLTAVRMETKNGVIVLDRADGSLATLSMQGQPDRAVALKRRDTAELLAEELRRLDPDNTYESAVKFGVEKLHTGGEVKAAAAEKPAEGEQKTPAAKKAPAKKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDJ4</accession>
    <name>A0A7K2ZDJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000669">
        <property type="protein sequence ID" value="MYW30437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13135" checksum="E3ADD5B5CC029436" modified="2021-04-07" version="1" fragment="single">MAFSADELRVLRRALAIALHPMPLSDEDVQDCLRLAGSVDEAVGEAGRLRAFLLADLARYRAALPGSVTGYLGLLQDALAAGYDPRPDDLAALRALRGKPLAAALLERCQILAERSVRARLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDY1</accession>
    <name>A0A7K2ZDY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000713">
        <property type="protein sequence ID" value="MYW30532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="220" mass="23070" checksum="F6A0ED2BEC47AEF3" modified="2021-04-07" version="1">MTRPVLFDLDGTLVDTPNAIVENFTATLAELGVPAASPEEIRSTIGLPLEKAFTQLIGVSAPAATVDAAVPCYQRLYRELIVPKAQSLLYPGVVEGLARLSEAGLLLAIATSKHTASAEVLLTAAGIRDRFAMVVGADAVTEPKPAPETGLLIAAELGHPADRAIMVGDTTHDISMAHNAGMRSVAVTYGIHSPDQLAAVRPTWTVSDFPAVVELILRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEI8</accession>
    <name>A0A7K2ZEI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000759">
        <property type="protein sequence ID" value="MYW30774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="417" mass="45544" checksum="0DD053D6219E4225" modified="2021-04-07" version="1">MKCPHTGAAETDLSAGTITIDPMVQDLDGETARLRDAGVLARIELLGVPAWTVTRHAEARRLLVDPRLVKDINAWGLWRSGAVTHAWPLIGMIDAGRSMFTVDGAEHRRLRTKTSQALTPRRLEAIRPAIEKFTDELLDNLDAARGEDGVVDLKAVFAQPLPMRVVGMLMGVDESQYAMLTRQYKAFFSMLTPQDERLSLLAELDVFYTDLVREKTAHPTDDLTSALILAEEGGEPLTEEEVVGNLKAMVAAGHETTIGLILNAVRALLSHPDQLAKVLSGEADWDAVIEETLRWDTPTTHLLMRFATEDITVGDTVVKEGEGVVISYRAIGRDTGQHGEDADAFDITRATRNRHMTFGHGPHICPGAALSRVEAAVALPALFARFPGLRLAIPDAEITKLPVMTQNDMAAFPVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZES3</accession>
    <name>A0A7K2ZES3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_16530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000768">
        <property type="protein sequence ID" value="MYW30836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="74"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="351"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="471" mass="49647" checksum="DEA98B3988BA56F7" modified="2021-04-07" version="1">MWTGGVTAFVVVAAGVGAYALYERFNGNISTIDIGDAGNNDVLSDGPMNILIIGTDKRTGKGNEGYGDKGSEGHADTNILFHVSEDRTNATALSIPRDLMTDIPDCETVQPDGSTKTIPGTPRVRFNVSLGQEGRNPGCTMQTVEAITGIKPDHFMMVDFNAVKELTTAVGGVKVCMAKPINDPKSHLELPQGESTVAGEDALALLRTRHSFGNESDLDRIKVQQQFLASMIREMKSSDTLTNPSKLFKLADAATNALTVDQGIGSAKKLMTLAQEIGKVDAKNITFVTMPVIDNPAEAVRATVVPHPTQAEPLFAMMRSDTSLTEVKQKEKAAKSKQAALLKGPKAAPADVRVDVLNGGEIAGAAGATVTWLQNQQGVLKSTNKANAPEKTKKTTLEYAPNQADQARALAEMMGLPAAAMKQGTADAEGLEAMVLTLGADFKGAGIPITGPAKISDDVERASADKAVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF82</accession>
    <name>A0A7K2ZF82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_17330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000812">
        <property type="protein sequence ID" value="MYW30992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="26"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="407" mass="42143" checksum="187D8137DA7822A2" modified="2021-04-07" version="1">MDTSVKQSPEPPAPAAAAPSPAAYRNLAMATIGFALTFWAWNLIAPMSGDYKDRLGLSSFQQSFLVAVPVLVGSLGRIPVGALTDKYGAKLMFPLVSALTIVPVLLLIPAKNSYGAMIAVGFLLGLGGTTFAIGVPLVNSWFPPAKRGFALGVFGMGMGGVALSGYFTPRIAKHGDNLPFLVVAGALVVFALLAAVLVSDHPDRKIPTDTLVHRLGEAGKLRVTWELSALYAIGFGGIVAFGVYLPTYLKTWYEMSPTEAGTKAAGFALVTVVFRPIGGWLSDRVHPALVTAGALLLAALMAVVQAFEPPLNPVGTIALLAMAAGLGTASGSVFALVSQVTPQPKVGSVTGIVGAMGGLGGFVPPLVMGAIYSAKDSYAIGFMLLSDLALAGCVYAYGRMRNIQRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFK1</accession>
    <name>A0A7K2ZFK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000856">
        <property type="protein sequence ID" value="MYW31131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="463" mass="49468" checksum="2BB44ADB8B9DBFEE" modified="2021-04-07" version="1">PAMGVPVDGLERAWVNELLGAAGSVLDAAARAVRYGDPVHLSATDLGVLKTPDNDVILVGPALRAADRLAALLDDVLEIAEGTGTDSGVPEHLAPDTRHRPTLLRLVPVVLKAVRRELHPGSPILRHAIRVAVVAVVGYFVGAALPLGHGYWAPMTAVMVMRPEFSQTYGRSVARFGGTLIGVGLATAIVQTASPDARLSALLAVVCAGLMYLLMRTGYAVSQVCVSAYVVFLLGMAGDDWSQTVTERIVLTLVGGLLAMVAYALYPAWETPRLRNRLAEWLVADGRYAATVVDRYADPAHRDLEEVRDALIATREARVAWQEALATAQHEPVRHRGISRAAATDAQHALAQLGRSAMVLEAHLPARSADPVPGAAQLAEALRRATERGAKAVRERRLPDWQPVVDAVAHWDVPTPTEDGTTPVGDPVVRRGAALLLDALEEFTRALDERGGSTRVSSTLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFQ7</accession>
    <name>A0A7K2ZFQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029492570" evidence="1">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="21087" checksum="B1F8446207EECC90" modified="2021-04-07" version="1">MIKRSGVLTAIGAAVASVALAAPSAIAAPTSWTITPTGAFTGSAGVTVLTDNNGNKIQCATSAASGSAPTSPVAGSPAQLASISAISFNSPCTGPFSSTWTVTTTVPWQIWGLDYAAGAGTNSTGQVTGEIRAIKAKVTGSSLLGPCTFDVTGKVAAKYNNPSAGGSNGTLNTAGGGLTLAIANKVGGGCGIVGTTASFQGLYTIKNTATGKSPVISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG95</accession>
    <name>A0A7K2ZG95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14500" checksum="B6FA4FDD25B2C1A8" modified="2021-04-07" version="1">EDGGPALGLLPRARWPRRQVELGAEWSLMMYTDGLIEGRAGAGSSQRLGQDGMVAMVNSRLEQGLAGEELLEAAVAEVRERHGGELTDDVAVLLLGRDPERIRRRGRSASRPGPVSAAPPATAPAAASVQRPPLYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGI4</accession>
    <name>A0A7K2ZGI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000922">
        <property type="protein sequence ID" value="MYW31450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="17760" checksum="086CA89C46AB54E7" modified="2021-04-07" version="1">MHGSESAREPGATAGTGVDHEFLALERELAVFLRRARASSGEMAREVHPELEPAAYGLLVRLESAGRQRATELAAYFGVGKATTSRQLRALEDLGLVAREPDPADGRAWLVRLTDEGLARFRSVRDARRGQYVRKLADWDRAEVAELARLLHQLNTRAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGK2</accession>
    <name>A0A7K2ZGK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_19680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000917">
        <property type="protein sequence ID" value="MYW31435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="462" mass="47449" checksum="D9FB574B325C60BE" modified="2021-04-07" version="1" fragment="single">MSGLLIRPRIRPRVAVVLVYTAAMCMNGLDSTIVNPALYTIAGDFGRPLSAANTVETAFLVALAVGLPVAGWLGDRFGTKRVFLGALTAFTIASAVCGLAPDLNTLVVARAVQGLAGGLLTPVGMTLLFRAFPPHERMKLAKVLIVPTALMPALGPPLGGLLTEHLSWHWLFFVNVPIGTAAVLLGVFGLREHVEGPEGKFDTVGFWLATPALGLLTYALGFGPSQGWTRPAVAVSAALGSVLLVAAVLHQVRANTPLLKLRLLADRVYGSASALAGVTAAGLMGVLFVFPLLYQASLGASALDAGLSVFPEAVGLMLASQVVDRLLPKLGPRLLTVPALLVAAAVFATLAIPGVAENAWSVRGLMFLIGLVLGTAVLTVQISGFESIGPADMGQAMGLFQIVRTLGGALGIAACAAVIGGGHVTEAAADPGPYRTAVWVTAALVAAGALIALRLPREAPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGQ5</accession>
    <name>A0A7K2ZGQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000953">
        <property type="protein sequence ID" value="MYW31543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS_4" evidence="1">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="20255" checksum="DBC94FB41FE42A38" modified="2021-04-07" version="1" fragment="single">MSYAETPAGSGTPPGGLDGALLKSLFAQSAVGLFVLDPQLRLVRANSLVEGVGTGEYIGLPFTVAFRLDDPQGSEQLLERVLAGGGPVREHLVRGRLRRIPGDRTFLVSAYRLDGPDGPDGPALGLLSAVVDVTERERARARETALAAVRDAVGGSLDVATTCRAFIDALVPGFADLAVIEVVDEVLRGADPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHC6</accession>
    <name>A0A7K2ZHC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_21215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001006">
        <property type="protein sequence ID" value="MYW31728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="4">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="484" mass="50951" checksum="5976047BE1CCB218" modified="2021-04-07" version="1" fragment="single">MTVQPADGLSPAAAFPDPSHDQWQSLVEGVLRKSGKEVSGSAAEEALSTTLEDGLTTRPLYTAHDTSPDTGFPGFAPFTRGSRAEGNAAGGWDVRQRHALSDPARLNEAVLGDLENGVTSLWLTVGGPAGVPVESLARSLDGVYLDLAPIVLDAPADLDAAATELLRLYEERGVAKGEARGTLGADPLGHEARTGIEADLTAAVRWAKVCGAEYPGLRAIAVDALPYHEAGGSAAEELGLSLATGVAYLRALTAAGLGVEEVCAQLEFRYAATADQFLTIAKLRAARRLWARVAEVSGAPGAGAQRQHAVTSPVMMTRRDPWVNMLRTTLATLGAGVGGADSVTVLPFDHALGLPDAFARRIARNTSTILMEESHLARVIDPAGGSWYVERLTDELAAAAWAFFQGTERAGGLPAALRSGMVAERLAATWAARSAKLARRKEPITGVSEFPMPSERPVEREPAPDAYAEAPGGLPRVRRDEAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHD1</accession>
    <name>A0A7K2ZHD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001004">
        <property type="protein sequence ID" value="MYW31725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="262" mass="27302" checksum="FF6A1C20D9068CB4" modified="2021-04-07" version="1">MKLAFSTLGVPGMPVAEVARLAAEHGYEGVELRAHAEEPVHPGLSSLERADVVEAFKAAGVEILTVAGYVQVAAEGDDEAVSADLADLVKLARDLGARYVRVFPGGGDQDPADADATAARRLGSAAPAAADMGVSILLETHDSHRAGADVARVVGTVGHPRIGAIWDVLHTWLADEDPAASHAVLAPHLGYVQVKDVASADDLTPLPLGAGALPLAACLEPLDADGWVCWEYEKRWHPDAADLPGLLSAGREHLLRLGAPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHF3</accession>
    <name>A0A7K2ZHF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YibE/F family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="450" mass="46516" checksum="B89A71672C88F302" modified="2021-04-07" version="1">MTSPQSDPAPQPPQPPQGHVHGHTHSHGPAAPVSKHLRKVIAAVVIPFATAVVVGLIAFWPGGVPDHERTGVGFDRQTQDGKVVQVVKVDCADVNAAQVPPTGDTSTPSGREAVNEQEGECAKATVEVTSGDDKGRKFVEVVQPDAPRQLREGQGVVVAYAPDAPRDLQYSVSDVNRKIPMTLLAAIFALAVIAVGRLRGVMALVALAVSFAVLTLFILPAILQGSNPLVVAVIGASAIMLAALYMCHGVTARTSVAVVGTLISLLLIGLLGSLFIGWADLSGNTDDNTGLIHGLYPDIDMSGLLLAGVIIGSLGVLDDVTVTQTSAVWELHQADPQMGWRGLYRAGIRIGRDHIASVVNTLVLAYAGAALPLLLLFSIAQSSVGTVANSELVAEEIVRTLVGSIGLVASVPVTTVLAALVVSADRPGAGTSSSTAAAPARTGRGRRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHF5</accession>
    <name>A0A7K2ZHF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroH</name>
        <name evidence="3" type="ORF">GT040_21520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001016">
        <property type="protein sequence ID" value="MYW31786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02185">
        <property type="entry name" value="AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008243">
        <property type="entry name" value="Chorismate_mutase_AroH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21164">
        <property type="entry name" value="PTHR21164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07736">
        <property type="entry name" value="CM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005965">
        <property type="entry name" value="Chor_mut_AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01796">
        <property type="entry name" value="CM_mono_aroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51167">
        <property type="entry name" value="CHORISMATE_MUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR005965-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="13087" checksum="6CA9C01A522DC844" modified="2021-04-07" version="1">MAVRAVRGAVQLERDEAGHMDERVGELLTAVLERNELVADDLISIWFTATPDLHSDFPAAAARGLGIVDVPLICAQELDIEGAMPRVVRLLAHVETYLSRAEISHVYLGATATLRKDIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHL7</accession>
    <name>A0A7K2ZHL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">GT040_21885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001028">
        <property type="protein sequence ID" value="MYW31853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738414.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001028.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="22550" checksum="ACF237C526848884" modified="2021-04-07" version="1">MGEQEVPTGPEKRRIGVMGGTFDPIHHGHLVAASEVAAQFHLDEVVFVPTGQPWQKSHKTVSPAEDRYLMTVIATASNPQFSVSRSDIDRGGPTYTIDTLRDLREVHGDADLFFITGADALSQILTWRDAEELFSLSHFIGVTRPGHVLTDDGLPEGGVSLVEVPALAISSTDCRERVAQGEPVWYLVPDGVVRYIDKRQLYRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHP9</accession>
    <name>A0A7K2ZHP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18-alanine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimI</name>
        <name evidence="2" type="ORF">GT040_22030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001036">
        <property type="protein sequence ID" value="MYW31881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="172" mass="18861" checksum="BF3875FF75CE460C" modified="2021-04-07" version="1">MSAATAAVLREMRWWDIAPVLELEHALFPDDAWSPGMFWSELAHARGPGATRHYVVAEDPATGRITGYAGLAALGDLADVQTIAVSRETWGTGLGSELLADLLKAATAFECATVLLEVRVDNLRAQKLYERFGFEPIGFRRGYYQPGNIDALVMRLTMHEHAAENAQETGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHR1</accession>
    <name>A0A7K2ZHR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPFH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001040">
        <property type="protein sequence ID" value="MYW31890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="33"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="29634" checksum="FA5315432CCF1499" modified="2021-04-07" version="1" fragment="single">MADITRRFGWRHLRSAPTAHIRHHKRGELAHDGRGLSFWYRSLSAALSEVPVDDRELAMAFHARTADFQDVTVQATVTYRVSDPALAADRLDFSVDPDTGSWRSAPLEQIATLLTETAQQHTLDVLARTPLAQALVDGVASVRERVATGLAAEPRLPATGIDVVAVRVVAIRPEAEVERALRTPAREQIQQEADRATYERRAVAVERERTIAENELASQIELARREEQLVDQRGTNARREAEEKAASDGVRTEAEAARKVRLARAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHS7</accession>
    <name>A0A7K2ZHS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type VII secretion protein EccCb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">eccCb</name>
        <name evidence="5" type="ORF">GT040_22185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001053">
        <property type="protein sequence ID" value="MYW31910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="99"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="456"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="745"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="474"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="762"/>
            <end position="769"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="961" mass="104654" checksum="E4159F6BB4B8FC36" modified="2021-04-07" version="1">TVGADQVNLVRTDRSRKERSVPLGRPDRLGPLGAESLARLLTPRRMSLGTDIAQPLDTDVELTTLLGIPDLHRHDPQTLFDRHSGSGRLRVPIAVGVDGRPVELDIKESAQGGMGPHGMLIGATGSGKSELLRTLVLGLALTNSSETLNFVLVDFKGGATFLGLEELPHTSAVITNLADEVALVERMQDALHGELIRRQELLRSAGNYTSALEYERARAAGADLTPLPSLFVVVDEFSELLSTHREFMELFVMIGRLGRSLGVHLLLASQRLDEGRMHQLESHLSYRIGLRTFSAMESRGVLGVPDAYELPAAPGSGYLKSGVEALTRFRAAYSSGTYRRRTGAVVQARVASQVVPWTSGWVVPRTLETPPEPEPETEEAEDEEALLDVALERLQGSGPAAHQVWLPPLDEPSPLDALLPGIEPDKVRGLTAARWPGTGKLRVPVGLVDKPFEQRRDPLIVDLSGAGGHVAVAGGSQSGKSTLARTLIAALALTHTPAEVQFYCLDFGGGGLSQLAALPHVGGVAARLNPERVNRAVAEVMTLLARREQFFVDHTLDSMQSYRRRRAAGEFPDEPFGDVFMVVDGWSTVRQDYDDLIPKFNELAARGLNYGIHLIITTTRWVELSAQVRDQAATRLELRMGDPMDSEIDTRKARSVPRTGGRGITADSKMHFLAGLPRLDGSGSLEDLGEGVAHLVAEIGRHWYGPSAPQVRMLPHRLPLSELPAPEATEGGGMRIALGLDQDALEPVWHDFSRTPHLIAVGDTESGKTNLLRLITKGITTRYAPSEAKIIAVDYRRTLVDAIPEEYRIGHVISLDNLNETIEGAARAMKTRVPGADISPARMRRCDWWTGPRLFVLVDDYDMVSGNSFQSPFEPVFENLTLGFEMGLHLVVARSAMGAGRGLSDGLIRRLDEANNPAVLLSCPPTEGRLFGNAKPLNLPPGRALHIQRRKPRLVQTALVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHU2</accession>
    <name>A0A7K2ZHU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_22255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001060">
        <property type="protein sequence ID" value="MYW31922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="307" mass="33571" checksum="27ED3767A6F74833" modified="2021-04-07" version="1">MGRYVIRRLLQMIPVFFGTTLLIFLMVNVMGDPIAGLCGDRQCDPATAAQLRSEFGLDKPVWQQYLTYMGNLFTGDFGTAFNGQKVTELMATAFPITIRLTIVAIVFEIVIGISLGVVTGLRRGRPVDTTVLILTLVVIAIPTFVTGLLLQLLLGVKWGIIKPSVSPDPTFDELLVPGLVLASVSLAYVTRLTRTSIAENARADYVRTAVAKGLPRRRVVVRHLLRNSLIPVVTFIGTDVGALMGGAIVTERIFNIHGVGYQLYQGILRQNSQTVVGFVTILVLVFLAANLIVDLLYAVLDPRIRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHV9</accession>
    <name>A0A7K2ZHV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_22315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029688689" evidence="3">
        <location>
            <begin position="36"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="235" mass="23477" checksum="E860603025107D35" modified="2021-04-07" version="1">MRRTSSALLRSPVAALLAVLLASSGVLLGAGGAQAAGYRYWSFWEGDGKSWAYATQGPSLVRPDDGTVQGFRFAVSEDSADADRPRHAPGFGAICADTPAKGGAKRVALVIDPGTAEDAPAGEKPPALRTACAQVAPDASSAEALASVAKPLRYDSSAMICAISGYPKSGCGEQVSGDGSTKDGSGKPTDTASASSVPAADDGDSGGGPSAGLLLGIGAVLLLGVAAVFQARRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIC7</accession>
    <name>A0A7K2ZIC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001092">
        <property type="protein sequence ID" value="MYW32110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="369" mass="40426" checksum="A65246AED76587EE" modified="2021-04-07" version="1" fragment="single">GFGSWQAQQVADAYEERAAGATHLSGLVVAQEQDDDGIDSLKVEADERTHRFETAFPEDFPEGSRVDIVVDGDWAALVAEPYDAFGWETLVLGGAVAALGFFANGVDGRTRSARLRRRPLPVLKVLVREGHEDARTRVFAADDREALRPVLHFHSLHAFEEEDEEEDEKEGEEEQKEGDEGEADGVGLTKVRQILSGDDPPPPLREAVLYGAPYAGAEVALAARLDADEPEVLVECSVTAVKPAVPGLLTRGPKSRERKNERRSVEEIAATMTPGPGLRVWKAHGFSRAVGLCLLVVQGGGIWATVDDGLSWVWLCLPVALAWMISAVATTLTWRITADRDGLWMTGAWRVRRLEWDAITAVRHHEDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIE8</accession>
    <name>A0A7K2ZIE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032782050.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001107.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="161" mass="17865" checksum="40AC0B41D3D3A3A0" modified="2021-04-07" version="1">MSDDEEGSEGVLLSGEENATVRIKLEREKRGWSTTTLSDHMNEAGFDMNPSAVWRIENRKRRINLDEAIGFAEVFGVPLSNFVGPPSLATMGRAMELIDNVVATYRASNRANHEARRARDQLDAYLADHPDIREEADVMVSNAIATELIKVNEEYGPASDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJE4</accession>
    <name>A0A7K2ZJE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fasciclin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001178">
        <property type="protein sequence ID" value="MYW32462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029853711" evidence="2">
        <location>
            <begin position="37"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="81"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="21824" checksum="4BB51F7275A5C677" modified="2021-04-07" version="1">MNTLHFRRTAVAVAAAAVLPLALTACSSGDSSKDSAAGSTPSAAASTSASADDSMTTDKPFGPGCASVPQDGAGSFDGMAKDPVATAASNNPELSTLVTAVKQAGLVDTLNNAENITVFAPTNDAFAKIPKADLDALLADKAELTKVLTYHVVGEKLTPKQLEKGSFDTLEKSKLTTAGSGTEYTVNDASKVVCGNVPTANATVYIVDSVLMPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJG0</accession>
    <name>A0A7K2ZJG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lantibiotic dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001191">
        <property type="protein sequence ID" value="MYW32483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="224" mass="24779" checksum="58C98BCC41EAB348" modified="2021-04-07" version="1" fragment="single">QREELVAHYWQRFCVKNDTIGFFGPVGWGRVDGSVGGVEVDPGEGLTASSSVFFSSWSIDALARTLSADERLMAWIPPRRTPFARIGRGDGGTFVRLPGRPEQPVPGELLPMLELVDGRRTLGDLARELSLPAGLAEEHLRELVRRRWVSWRLEVPSGARPDRELRAVLERVGDAELRRGALEPLEVLERGRERVEAAGRDAEALCGALAALEEDFTRITDTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJW0</accession>
    <name>A0A7K2ZJW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_25945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001205">
        <property type="protein sequence ID" value="MYW32621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="6">
        <location>
            <begin position="50"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_DH" evidence="7">
        <location>
            <begin position="595"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1383" mass="146934" checksum="9A146ECE580D8597" modified="2021-04-07" version="1">SVVPERSVVPERSAVTVPSAVRGASAVSEASAVREASAGAEPSGGGREPVAIVGMSGRFPGARDTDEFWDLLASGRDAVSKVDRWDLASLGSVCLDGGLLDGVDEFDPLFFGISGAEAVYMEPQQRLFLQEAWRALEDAGHAGDSLDRDRCGIYVGCAAGDYLDLTGPSDYPGQALWGNMNSLVPSRIAYYLDLHGPAIAVDTACSSSLVSLYLACQALWAGEVTTAIAGGVYVQNSPRLYLAASRAGMLSPTGRSRAFDQAADGFVPAEGVGALVLKRLSDAEADGDHIHGVIRGIGINHNGTTNGIAAPNGTSQERLIRQIYQDFAIDPAGIGLVEAHGTGTKLGDPVEFRALDRAFRGFTDAERFCSLGSTKASIGHAQAAAGVIGVIKTLLAMRHEVIPGLPHHTETNSSVTLAGSPFFVHTEPRRWAVSEGGRRRAAVTSLGASGTNAHAVIEQSSKPPTAGRSRRGVARLIVLSGATEDALREQVARLARHCRAHPDLDLGDVSHTLLLGRRHLRHRWARVVRDSAELESRCTAWLAGQDLPARSADSVPRALAQQFLDGGSPDFTELFRDGRYRRVPLPGYPFERERYALPNRATADDGPRRDEEVLNGDEFYLREHQVQGTGIAPGAMYLHWAAAAARRTASDPVRLRDIAFLRPLSVSGAPRALRVALHAEGDITRFTVSSTESAGDDPVLHCQGEVSAAEPTAAQALDLPALLRDFRSTAFDPQRFYAEWRERGIAYGPTFQGVVAVHRGDNAVLAELRLLSTASGTTEGHALHPALVDAAMQCMRLLDGDGDGDDGGDRVGLVFGIKSAEVLVPGATVRWALIRRAGDARGADRIDIDLATDDGTVCLRLRGIAGRRTERTPDTARAGRTPDPADGVTTLVPVWDPVQQAESATWPRSSASVGVIAPPGRARDVLLTRFPGAHLVGDPSQRTYDDLGTSLRSVPELDHLLWVAPGAVDDRSGASVVESQAGGSLHAFRTVKALLAAGYGDRSPGLTLITERAHAVHEAEVVDPAYAGVAGLAGSTAKEYPNWRVRVADVEAYDAPSLDAVLGLPADPDGNLRIHRDGRWHGQRLMTVQPAPPTSSRLRQGGTYVIIGGAGALGTVISEYLIRRYHAQVVWLGRRPQDARVEAAVASATGADGPAPLYLRCDATDLVSLRAAKDEIVRRFGAVHGVIHSGLVFSGASLARMSEAQFEDVLRGKVDASVRCMEVFGDGALDFALFLSSINSYLKAIKQANYAAACTFLDAFALTVQRRYGAAGKVLNLGYCFNNAPTEGERGAVVGAQAPLIQPDELTAAIERLCAAPVSRLTLMKFSPALNNRGIVLGDDDVILPSAVEPDAVPADVQEPAVASPGELERLRIRIAELTALAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK39</accession>
    <name>A0A7K2ZK39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001238">
        <property type="protein sequence ID" value="MYW32714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="11704" checksum="F683C7F89607E072" modified="2021-04-07" version="1">PERNPAPQQTPTPEQAATFRRMHANLPVFLEHVLCPFSGYVPDLVALKVSAAHLVVGVGRDSRALLPAVAAEGLARRVGVGVAEFPGGHIGLTEHPRAFAARLREVLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK65</accession>
    <name>A0A7K2ZK65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ORF">GT040_26590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510592.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001248.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="19010" checksum="FB88AFE727ADF89D" modified="2021-04-07" version="1">MSRIGKLPIQVPAGVDVTIDGRTVAVKGPKGSLSHTVAAPIEVSKGEDGVLNVTRPNDERQNKALHGLSRTLVANMITGVTTGYSKALEISGVGYRVQAKGSNLEFALGYSHPILIEAPEGITFKVESPTKLSVEGIDKQKVGEVAANIRKLRKPDPYKAKGVKYAGEVIRRKVGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKT8</accession>
    <name>A0A7K2ZKT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001299">
        <property type="protein sequence ID" value="MYW32967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10287" checksum="11A34516EEF0075B" modified="2021-04-07" version="1">MGFESRADTTHQDRPRTPEPPDAAPETVGEAAVLVGGPADGTRIRVTGRPAVVQVTYPCELDGPSDGARAEALYVYRRDLQVERAPLRYGVDPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKU9</accession>
    <name>A0A7K2ZKU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001299">
        <property type="protein sequence ID" value="MYW32976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="158" mass="18091" checksum="DB84859A9FAB58E0" modified="2021-04-07" version="1">METETATRWLSETEQCAWRTHLDVSRLLMHQLEKDLQPFGLTMNDYEILVNLSESEEQRMRMSDLAAATLQSKSRLSHQITRMESAGLVRRTHCESDRRGLYAVLTELGAETMRKVAPHHVESVRNHFMDLLSPEALAELNAALTPIAEHLRGRRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL57</accession>
    <name>A0A7K2ZL57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001310">
        <property type="protein sequence ID" value="MYW33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="17714" checksum="2D2BB3D704F699DA" modified="2021-04-07" version="1">MLIRKATTEDWSAIWPFFREIIAAGETLTYPLDLGKEDAQGWWYVAAPNRVVVAVDEAGAVLGTAKMNRNHMGNGSHVASATYMVDPAHSGKGVGRALCTYSVEWARTSGFRAMQFNAVVETNTRAVKLYESLGFEVIGTLPEGFNHPAEGYVGLHIMHKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLJ7</accession>
    <name>A0A7K2ZLJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_29125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001354">
        <property type="protein sequence ID" value="MYW33221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="174"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="246" mass="25691" checksum="327C085E11814D79" modified="2021-04-07" version="1">MSESVQAQGALEAPEAPEAPIKVLLADDQALLRSAFRVLVDSEPDMEVVGEAADGAQAVELARETGADVVLMDIRMPGTDGLAATRMISADPALAAVRVVMLTTFEVDEYVVQALRAGASGFLGKGAEPEELLNAIRIANAGEALLSPAATKGLIATFLAQGGSSGEGPDSAEYAERLAALTVREREVLVLVAGGHSNDRIAERLAVSPLTVKTHVNRAMAKVAARDRAQLVVIAYESGLVRPRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLM0</accession>
    <name>A0A7K2ZLM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001360">
        <property type="protein sequence ID" value="MYW33264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8287" checksum="8F31B6D8B734982F" modified="2021-04-07" version="1">MTGDARERCTPEPGSFAVDGRDGRVGRVTGRAGDDVRLRPPGGGPEWSCPPDALRPAPPGVALRARVTEINREGQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLV6</accession>
    <name>A0A7K2ZLV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001358">
        <property type="protein sequence ID" value="MYW33249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="19852" checksum="6B577638A636B33C" modified="2021-04-07" version="1">MTLHDDATLVLKGYAPEHEAGADVGQAELRQAYLDHLAHHHDGMWKACDAGHVTASALVIDPERGKVLLTLHRKLRMWLQMGGHCEEQDTTLAAAALREATEESGITGLTLLPGGPVRLDRHPIPSPCNWHLDVQYAALAPAGAAERISEESLELRWFGYEDVASVADASVVRLLEATRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM30</accession>
    <name>A0A7K2ZM30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001375">
        <property type="protein sequence ID" value="MYW33329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
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        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="11569" checksum="63B4DACB4AF9D00F" modified="2021-04-07" version="1">GYLLKDAPPQELAAAVRTAAAGRSALAPSVAHRLMDRMRTPAEALTRRELEVLQLVGEGLSNLQISKKLFLSQATVKSHLVHIYAKLGVDSRTSAVAAATARRLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZML5</accession>
    <name>A0A7K2ZML5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isocitrate lyase/phosphoenolpyruvate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001434">
        <property type="protein sequence ID" value="MYW33560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="26939" checksum="B081F2A35B5F559E" modified="2021-04-07" version="1">MDFRTTVERAERLKQLHADHQPLVLPTVWDAWSARTAAGAGFSALTVGSHPLADSRGAEDQEGQTFEEVLAAVRPIIASVDIPVSVDLEAGYGQKPADLIAGLIEVGGVGLNIEDTVHSEGGRVRTTQEHASYIAGLRAAADDAGVPVWINGRTDLFAHAEDAAAVLDEAIERLLALEQSGADSVYPVKIQDDDELLAAVTAAVSVPVNSTAHPVKHDLERFRRLGVGRITYGPLLQMALTDAMKDMLGPWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN62</accession>
    <name>A0A7K2ZN62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_31795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001448">
        <property type="protein sequence ID" value="MYW33728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="25589" checksum="1E0956A6CBBA1BD5" modified="2021-04-07" version="1">MTLVAILSGAGISTDSGIPDYRGPNGVWRKDPEAEKLVTYDFYLADPEIRRRSWQMRRTSAAWMAEPNAAHRAVVDLERSGTPVRVITQNVDGLHQLAGLPARKVLELHGTAREVTCTRCHARSSMGEALERVEAGEADPACAVCGGILKAATVMFGERLDPRVLADAMTVAKACEVFVAVGSTLQVQPAASLAGIAAEHGARLIVVNAEPTPYDELADEVVREPIGTALPRLLAGLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNC7</accession>
    <name>A0A7K2ZNC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na(+)/H(+) antiporter subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_32480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001487">
        <property type="protein sequence ID" value="MYW33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="22733" checksum="E69A26A583E3559B" modified="2021-04-07" version="1">MTVSASLLLTAVVLCAVGALLMLTRPLTRILLGAVIMSNGVNLLILASTGTAGAAPLLYGVDLRRVTDPLPQAIALTAIVITLGTTAFLLAMAYRSHQITGTDEVHDDLEDRRIVLRAEVLSERAELREEFRSGAEPTPDERERYREERRRLRDRLRADRARQARGRDASGDLWHDVIGADPEDYEREGDAKTDDRYPRDGRGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNE7</accession>
    <name>A0A7K2ZNE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001488">
        <property type="protein sequence ID" value="MYW33875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="21339" checksum="92C93A938F442592" modified="2021-04-07" version="1">MNYRVQPTAQVDESAEIGAGSSIWELAQIREGAKLGEGCVVGRGAYVGSGVRIGDNVKLQNFALVYEPAELGDGVFVGPAVVLTNDQYPRSVDPDGKQKRGGDWEAVGVKVAEGASLGARSVCVAPVRIGRWAMVAAGAVVTKDVPDFALVVGVPARRIGWVGRSGVRLVARGGEPGVWECPQSGAVYEEGDGVLREQRITPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNI5</accession>
    <name>A0A7K2ZNI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbhB/YbcL family Raf kinase inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001493">
        <property type="protein sequence ID" value="MYW33900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="18824" checksum="ACDFF14184D30074" modified="2021-04-07" version="1">MTEPKRAPLPHDFHPEVHAFTVTSKDLAPGAVLADAQVLASGNTSPHLRWEGFPAEAKSFAVTCFDPDAPTGSGFWHWVVFDIPASVTELPAGAGSGAFEGLPEGAVQARNDYGSKEFGGAAPPTGENHRYVFTVYAVDTEKLGIDSDSSPAVVGFNLRFHTLGRAQLIGEYEAPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNQ5</accession>
    <name>A0A7K2ZNQ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lepA</name>
        <name evidence="7" type="ORF">GT040_32735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001494">
        <property type="protein sequence ID" value="MYW33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="17"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="624" mass="68501" checksum="11CAC06D23452B0E" modified="2021-04-07" version="1">MPAIPSNVPEPSRTDPALIRNFCIIAHIDHGKSTLADRMLQLTGVVDQRQMRAQYLDRMDIERERGITIKSQAVRLPWAPNTGEDTGTTHVLNMIDTPGHVDFTYEVSRSLAACEGTVLLVDAAQGIEAQTLANLYLAMENDLTIVPVLNKIDLPAAQPEKFSEELANLIGCQPEDVLKVSAKTGVGVDALLDRVVRDVPAPVGVADAPARAMIFDSVYDSYRGVVTYVRVIDGQLNKRERIRMMSTGATHELLEIGVSSPEMTPADGIGVGEVGYIITGVKDVRQSKVGDTITSLHNGATEALGGYKDPKPMVFSGLYPLDGSDYPDLREALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHLDVVRERLEREFGLDLIATAPNVVYRVEMEDGTEHVVTNPSEFPEGKIDKVHEPVVRATVLAPSEFIGAIMELCQGRRGTLLGMDYLSEDRVEIRYTLPLAEIVFDFFDQLKSKTRGYASLDYEPTGEQSAQLVKVDILLHGDKVDAFSAVTHKDKAYAYGVRLVAKLQKLIPRQNFEVPIQAAIGARVIARETVRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGNVEVPQDAFISVLSTDESAGESKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNW0</accession>
    <name>A0A7K2ZNW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001539">
        <property type="protein sequence ID" value="MYW34054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="268" mass="29003" checksum="1365165835A1C4AC" modified="2021-04-07" version="1" fragment="single">MTVTPDPDGPPPLEVTPAPEGPPPLEVVEYTDPLCPWAWGSEPAFRRLRAALAGRVHWRRAYAILFDDDEDDPPPDPAAETAWYAGHLADIGAHTQAPRAHRLSRVAASSWPSSLVARAAEAQGPEIAERVLRRLRESVFVLGEPADTEALALRSVRGVPGLDPGRLVRDTASVDVRGSVRADRAEARRPVPEVFSVRERSPHPGAAKETPGGEVRYALPTLLFRTPGAYRVVPGWRPYEAYAAAVDALSPGLRQEAAPLAPGRALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNW2</accession>
    <name>A0A7K2ZNW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lasso peptide biosynthesis B2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001538">
        <property type="protein sequence ID" value="MYW34035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029583833" evidence="1">
        <location>
            <begin position="26"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Transglut_core3" evidence="2">
        <location>
            <begin position="76"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="186" mass="19310" checksum="BA737408BB648F8D" modified="2021-04-07" version="1">MPQLLAVHLLRIGALYPTPAPVPWAAPVSALAPAASWGSAEHPAGLAKATGRFSTAAATALVATSFIQRAGPRARAMNRLVSALRASAAVARRSASPTEAADAVLAVRRTAWHSPARTACLEESAAAAFLLATRRLSIVWCHGIAADPVRLHAWVPTVDGNTVAEPPSTLAYTPALTIGAHHQHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNX0</accession>
    <name>A0A7K2ZNX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001538">
        <property type="protein sequence ID" value="MYW34037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="424" mass="45505" checksum="E9A687D1B98311C6" modified="2021-04-07" version="1">MAPEGIGALLRGIREAAGLTREEQAAVLQAAQDGKWFDPENLKRWETEKRLPTPMWHALLAECYGTSTDEIVRAVAASRRRRRLHRLIGEEAREEGSVVDRRKFLGVAAAATGMAGLPDIAEARQGINAGLSTSDSGDLAYLSGAFERHRGGYRGRPPNEVLGEMWVDLDLLRELLGRPHPASVRKDLARTAAGITGLVAIIQHDRGEQRDAVGWFATAEQAARESGDRHMLAWVLSRHAMVPLNYGAPHAAATMAIRARAEAGRSPSAAGALAAAVTARSLASVGDREGALRAVADARAAAARLDSVQGADTWFGYPPQKHHVHLSQAFTLMGRTREAYVEQESALSLTTSPSVMSRALIAVDRAACVRADGDPATAADLAVNAWLQLPTAYRDGLVRSRVESLCQSLSGRPGSTLREALTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP51</accession>
    <name>A0A7K2ZP51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001545">
        <property type="protein sequence ID" value="MYW34117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029698655" evidence="3">
        <location>
            <begin position="33"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="408" mass="41479" checksum="15D6985EEB5B1C52" modified="2021-04-07" version="1" fragment="single">MPDSRRFRLSSLASAAGLVPAALVITAPRATAAPTPTPTPSPSGTENPCDLIVGLARDYCEDGENARSGSRAPTDIDNPADPLTSLAQGCADAAAWIVGKLSEAVESTANVDFTNPKFLQQYAVIFAASTILTLVLWLLAVTKRAIRGVPLTTAISEAVGFLWLTVLASAFTPLILYTIVSATDGVTEVIASSTGGQTDVFFGSFAEALKKGTDIGGGPIMLIVVSLVSIVAAGVLWLELVIRAALLYVGALLGIVVYAGLVDKNMWGHVRRWAGIMIAVIMVKPVIVIVLGLAGALSAGDGPDAFSAVVSGLAIILLAIFASAMIYRFVPGFGDEIQGARTNRKQATDGAQAAALISSPAALVSQGIKTHSGRTDQNSGGGGGGARPSNPASGGVAAHSSRTSGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPF5</accession>
    <name>A0A7K2ZPF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4190 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001585">
        <property type="protein sequence ID" value="MYW34251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="2">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="139" mass="14238" checksum="64E20BEAA082B147" modified="2021-04-07" version="1">TTGHYGYPAPPAQPYGGYPGYDAYGGQQPWGPQPSNGLGTAALVLGIISVVGFCMYGVNIILGILALIFGIIGLGRAKRGEATNRGMALAGIITGSVGIVIGSVLLGFIIWAIANGDSSFDDTYEDDPFATSLVIEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPQ2</accession>
    <name>A0A7K2ZPQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rpsO</name>
        <name evidence="7" type="ORF">GT040_34875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001592">
        <property type="protein sequence ID" value="MYW34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003965855.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001592.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZPQ2"/>
    <dbReference type="GeneID" id="6209738"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10881" checksum="EDD883F9E57FF456" modified="2021-04-07" version="1">MPLDAATKKQIMSEFAQKEGDTGSPEVQVAMLSRRISDLTEHLKTHKHDHHSRRGLLILVGQRRRLLQYLAKKDIQRFRALVDRLGIRRGAAGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPS8</accession>
    <name>A0A7K2ZPS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpB</name>
        <name evidence="13" type="ORF">GT040_34750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="WWKE01001589">
        <property type="protein sequence ID" value="MYW34298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="64"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW34298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="428" mass="45610" checksum="8DF9BD20C15041B8" modified="2021-04-07" version="1">MTSEFFIPDPEGLIPSAEGYFGAYGGKFIPEALVAAVDEVAVEYDKAKSDPAFAAELNELMVNYTGRPSALTEVPRFAEHAGGARVFLKREDLNHTGSHKINNVLGQALLTKRMGKTRVIAETGAGQHGVATATACALFGLDCTIYMGEIDTERQALNVARMRMLGAEVIAVKSGSRTLKDAINEAFRDWVANVDRTHYLFGTVAGPHPFPAMVRDFHRVIGVEARRQLLERTGRLPDAAVACVGGGSNAIGLFHAFIPDTDVRLVGCEPAGHGVETGEHAATLTAGEPGILHGSRSYVLQDDEGQITEPYSISAGLDYPGIGPEHSYLKDIGRGEYRAVTDDAAMQALRLLSRTEGIIPAIESAHALAGALDLGKELGKDGLILINLSGRGDKDMDTAARYFGLYDTDAAVEADADSDRAEIVGDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPT3</accession>
    <name>A0A7K2ZPT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-ribitol-5-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.40" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001586">
        <property type="protein sequence ID" value="MYW34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047349">
        <property type="term" value="F:D-ribitol-5-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="26840" checksum="33D21013821355B8" modified="2021-04-07" version="1">MNVALLFAGGIGSRMNSRALPKQFLEVHGKPVIIHTLQHFEAHPEIDAIAIAILPEYREHMMKLLTRYEIQKVKWVIDGGKTGQESRHNALRTVAAECPEDTVVLVHDGVRPLIDAKLISSNISTVLEHGSAITCTKFNETVVSSEHDHIDDVIPRDHIYAAQAPQSFRLGEILSLYDRAVEEGEHDSIDSCSLMHRYGRKIYRVVGPRSNIKITTAEDFYLCRTYFEILENQQIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ22</accession>
    <name>A0A7K2ZQ22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium transporter TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001622">
        <property type="protein sequence ID" value="MYW34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026278">
        <property type="entry name" value="K(+)/H(+)_antiporter_KhtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005028">
        <property type="entry name" value="KhtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16635" checksum="80F2B62E3CF42BCA" modified="2021-04-07" version="1">MGTRRTSLPGVGAQYDFTTESGQHISVVVHHDGRRFIGFYEQDDPDSCRLSVPLTTAEATALAHLIDPAPIDAVRTEGIDLVTEHIPLGSRSPYGGRLLGETRARTRTGASIVAVLRTHSAHPSPEPNFRLAIGDTLVAVGTREGVDALSEIIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ56</accession>
    <name>A0A7K2ZQ56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001625">
        <property type="protein sequence ID" value="MYW34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="91" mass="10153" checksum="5B296BC4E221F69C" modified="2021-04-07" version="1">MARHTFETPDDVTEPPLRPNTDGVKVGADLARRRKTPTAATDWKSFSSYLPEDIQRAFRAECILAGIEVRQGLDQAVRTWLESRQAGKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ77</accession>
    <name>A0A7K2ZQ77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">GT040_35945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="WWKE01001634">
        <property type="protein sequence ID" value="MYW34526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515226.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001634.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="57"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW34526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="183" mass="19257" checksum="AE6D6E5B92E96C4A" modified="2021-04-07" version="1">MTSTTESTRELLLSRIRDVADYPKPGVVFKDITPLLADPVAFTALTDALAELCVRHGATKIVGLEARGFILAAPVAIRAGIGFVPVRKAGKLPGATLAQAYELEYGSAEIEIHAEDLVPEDRIMVIDDVLATGGTAEASLELIRRAGAQVAGVSVLMELGFLSGRARLEPGLRGAPLEALITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQB2</accession>
    <name>A0A7K2ZQB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DoxX family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_36095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001638">
        <property type="protein sequence ID" value="MYW34554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6342" checksum="7E21503C04E3800A" modified="2021-04-07" version="1" fragment="single">MVCVNRRDLGLLALRVGTGAVLAAHGSQKLAGWFGGGGIQGTTAAMEAMGFHPPKHSAVAAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQL0</accession>
    <name>A0A7K2ZQL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001652">
        <property type="protein sequence ID" value="MYW34615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="20373" checksum="DA8148C2DC5F99C6" modified="2021-04-07" version="1">MTHRVTLVAAARTSPRLAERFDDDRPLDQAGWHEVQLVAHTLVPLGAAELRYCSPTPRSRATGDALGYAPMVQPALRDCDMGRWRGMTLAEVAAREPAAVAAWLADPGGSPHGGESLLAFIGRIGGWLDTRPACDGFIVAVAEPAVIRAALVYALNVPPTAYWNVDVRPLSTITLAGAPGRWSLSLESGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQS2</accession>
    <name>A0A7K2ZQS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_36755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001678">
        <property type="protein sequence ID" value="MYW34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="29075" checksum="C7B9DCC081CD4E19" modified="2021-04-07" version="1">MQRLTAESVTLGYDQRVIAEDLSVEIPDNSFTVIVGPNACGKSTLLRSLARMLKPSRGQVLLDGQVIHQLPAKKVARTLGLLPQSSIAPDGITVADLVARGRYPHQGLLRQWSPEDERVVQESMESTGVAELADRYVDELSGGQRQRVWIAMALAQQTPLLLLDEPTTYLDIQHQIDVLDLCAELHETQGRTLVAVLHDLNHAARYATHLIAMREGEIVAEGAPSDVVDAELVERVFGMRCQVIDDPETGTPLVVPAARKARQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQW8</accession>
    <name>A0A7K2ZQW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001672">
        <property type="protein sequence ID" value="MYW34649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="10008" checksum="0D89F950C41F3DAA" modified="2021-04-07" version="1" fragment="single">GAYGSDVARYARWAAEGDPGAAPTSAQAVPGAGIAPALRAVRGRAPELLWHLTTHPDRRRRLLARLDPTDLPPRIAADLGAPDEQELAVLRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRD8</accession>
    <name>A0A7K2ZRD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aceE</name>
        <name evidence="12" type="ORF">GT040_38210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="WWKE01001732">
        <property type="protein sequence ID" value="MYW34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="150"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="490"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="910" mass="101325" checksum="1EEB31F2346C6C5A" modified="2021-04-07" version="1">MASGSDRNPIIIGGLPSQVPDFDPEETQEWLDSLDAAVDERGRERARYLMLRLIERAREKRVAVPEMRSTDYVNTIATKDEPFFPGDEEIERKVLNATRWNAAVMVSRAQRPGIGVGGHIATFASSASLYDVGFNHFFRGKDQGDGGDQIFFQGHASPGIYARAFLLDRLSEAQLDAFRQEKSKAPNGLSSYPHPRLMPDFWEFPTVSMGLGPLGAIYQARMNRYMEARGIADTSKSHVWAYLGDGEMDEPESLGQLSIAARENLDNLTFVVNCNLQRLDGPVRGNGKIIQELESQFRGAGWNVIKLVWDRSWDPLLAQDRTGILVNKLNTTPDGQFQTYATETGEYIREHFFGDDPRLRDMVKDMTDQQILHLGRGGHDHRKVYAAYAAAKAHKGQPTVILAQTVKGWTLGPNFEGRNATHQMKKLTVEDLKRFRDRLHIPITDKQLDEGYPPYYHPGRDSEEIQYMHDRRNSLGGYVPTRVVRAKPLPQPEEKTYAAAKKGSGTQSIATTMAFVRILKDLMRDKEIGKRFVLIAPDEYRTFGMDAFFPSAKIYNPLGQQYEAVDRDLLLAYKESPTGQMLHDGISEAGCTASLIAAGSAYATHGEPLIPVYVFYSMFGFQRTGDQFWQMADQLSRGFVLGATAGRTTLTGEGLQHADGHSQLLASTNPGCVAYDPAFGYEIAHIMQDGLRRMYGEANEDVFYYLTVYNEPIQHPAEPENVDVDGILKGVHRFKQGGAGEIPAQILASGVAVPWAVEAQKILAEEWNVKADVWSATSWNELRREAVDVERYNLLHPEEEQRVPYVTKKLEGAEGPFVAVSDWMRSVPDQIARWVPGAYQSLGADGFGFADTRGAARRFFHIDAQSIVLAVLTELAKEGKIDRSALKTALDRYDLLDVAAADPGAAGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRI1</accession>
    <name>A0A7K2ZRI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001729">
        <property type="protein sequence ID" value="MYW34942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241699.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001729.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="27865" checksum="CB5F915E9DACBA6F" modified="2021-04-07" version="1">MPRPSVAELRPVVHPPGVKDRRSGEHWAGRMYMREVSLRVDRYLVNTKVTPNQVTYVMTLAGVLAAPALLVPGIPGALLGVLMVQLYLLFDCVDGELARWKKQYSLSGVYLDRVAAYLCDAAVLVGLGLRAADIWGEGRIDWLWAFLGTLAALGAIMIKAETDLVGVARHQGGLPPVKEAASEPRSSGMALARRAAGALKFHRLILGIEASLLILLVAILDTIGGDLFYTRLATAVLAGIALLQTLLHLVSVLASSRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRJ7</accession>
    <name>A0A7K2ZRJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001734">
        <property type="protein sequence ID" value="MYW34975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21522" checksum="1BC263D4ACE492D8" modified="2021-04-07" version="1">PAPPAAAPVGAGKINLDKGRVNLQKNQTVSLVKGGAPLLSQVKMGLGWEPAFRGKDIDLDASVIAYGPNRNHLDSCYFGKLSILNGAIKHSGDNLTGEGAGDDETIVVDLGRIPAEATGLVFTVNSFTGQKFNEVAKAYCRLIDAATGEELVRFDLTGAEPQTGVMMAKLIKQFTGEWEMTAMGEFVKSRTVRGMVKPAAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRL7</accession>
    <name>A0A7K2ZRL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001728">
        <property type="protein sequence ID" value="MYW34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="16"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="369" mass="38619" checksum="5CABCAA92B39BC13" modified="2021-04-07" version="1">METELSRELGIEHAIFGFTPFPAVAAAISRAGGFGVLGAVRYTDPQELARDLDRLDKLADGRPYGLDVVMPAKKVEGVTEADVEAMIPAAHRGFVQDLLTRYGVPELAEGEASGWRITGWMEEVARNQLNVAFDHPIKLLANALGSPPADVIERAHAHGVLVAALAGSAEHARRHAAAGIDVVVAQGYEAGGHTGEIGSMVLVPEVVEAVAPLPVLAAGGIGSGEQAAAGLALGAQGVWLGSLWLTTEEADLHSAALTRKLLAAGSGDTVRSRALTGKPARQLRTAWTDAWDDPAGPGTLPMPLQGLLVAEAVSRIQKYEVGELLGTPVGQIVGRMTSERSVQAVVDDLTRGFERAVTRINRIAGRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRS0</accession>
    <name>A0A7K2ZRS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001759">
        <property type="protein sequence ID" value="MYW35046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="27273" checksum="74E4DFC5E94514DC" modified="2021-04-07" version="1">PGVRAGLRSALEAAAAFAEAWAATGGGPFPVPDAGEPGEEIVERTGFDAAVGWWTLPQWEMAAVALLNHRAVRAGAGGDRHELLRLLTAVEEASGRQFRSLGHALRVLDDEPLVALHRTSGTGYALRFFGIGDNFQLHTLLADALIGGGHVEGRAPSPQEVAVCRETPGQVDTVGSFDLTAPDGGRLWNEGAPADIPVVDGVRLLVLDEPSYRRSWPAGRFFPGMRGDVILERALEPEETERWFARVSPAKELTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRV5</accession>
    <name>A0A7K2ZRV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_38800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001770">
        <property type="protein sequence ID" value="MYW35073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="33300" checksum="A0A1361E9B6BE5BB" modified="2021-04-07" version="1">MTTIEIDHTSRWFGNVVAVNDVSMTVGPGVTGLLGPNGAGKSTLINMMGGFLAPSTGKVTLDGQPIWRNESVYKKIGIVPEREGMYDFLTGKEFVVANAELQGLGGAEAQRALATVQMEYAQDRKISTYSKGMRQRVKMASALVHEPSVLLLDEPFNGMDPRQRMQLMELLRRMGAEGRTVLFSSHILEEVEQLASHIEVIVAGRHAASGDFRKIRRLMTDRPHRYLVRSSDDRALAAALIADPSTAGIEVDLTEKALRIQAVDFGRFTELLPRVAREQGIRLLTVSPSDESLESVFSYLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS32</accession>
    <name>A0A7K2ZS32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1648 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001779">
        <property type="protein sequence ID" value="MYW35142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="34437" checksum="10107A653E467B7A" modified="2021-04-07" version="1">MTRKNLGRATLAALPFALAFLVDLILFLVLKDRLPTRLAGHFDVSGDVNGYVDRTTYVLVTAPVMPVLGVLWVLMVVGGKFYGRAHRLLIGGGWAVAAFLQYVLAAALIVNLDAPDGSAAGRFPLWHLAVAIGAAVLAGGIGLLLARLVPPTEGPRAGKSPADRERIALADGEVAGWARTTGSWWLPLGGLVIVVTGTGLGYWVTWFLGAPLLVLALLVLTFSRAHVTVDRRGLTVSGLLPWPRVQVPLERIEAADSRRVDAVAEFGGWGYRIRPGRTGFIVRSGEAIVARQRSGREFAVTVEDSGTGAALLNTLVDRNRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS78</accession>
    <name>A0A7K2ZS78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001790">
        <property type="protein sequence ID" value="MYW35203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="164" mass="18399" checksum="311EEF35B8DE66AA" modified="2021-04-07" version="1">KDLAALRAHATHPDRTAAQNATPANATLRWSSDKGWVERGGPLGEPAETASLPTLAQVTSAEQRWADREEDITTVGGDPFEVGQVFARRWMERLPETVHLQKLSTMYPRIPHRIDGELLRYAARFGLLAHKDDQIDEHDRYAIRAGFWREIDVRAAAEHVPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS93</accession>
    <name>A0A7K2ZS93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001784">
        <property type="protein sequence ID" value="MYW35177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="27169" checksum="D35E446088D3E859" modified="2021-04-07" version="1">MGTTQLESVQEPKYWHLKTVLSEALDSDFAVGEILPNERDLAARFGVARATLRQALEQLELEGRLQRRRGVGTTVAPPRVGVAVSTAQHEWTGGVTGEAWQPVDCASEAAPSAVAAMLGTGTEPVHVVRRIRDTHGQAVAAELLYVPASSVPDLSAIDAPSGTVRARAVLRELHRLGLEGQDRSVELGSARADDAKELDRLPGAPVLVVTTRYFAAGGTAAVSIATYRADTCRLTFGDSGALEISHDEQQERQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6C6</accession>
    <name>A0A7K2Z6C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000041">
        <property type="protein sequence ID" value="MYW27872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="16907" checksum="74EAE197B75269DE" modified="2021-04-07" version="1">PEIVARTLVWAGLPADFGPFFWAQPGQPVVPTLGELAAQRQVQAAPDAGSYLVMGTDFGRAICVQYGTANIVAVPVEAGPGGQSVAPQFVNTGLPEFVRSMALLGRMWRLRFGLTPEQAGRWTVDFQAQLVALDPAALASPESWWSVLLEQMWDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6E6</accession>
    <name>A0A7K2Z6E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dyp-type peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_01150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000056">
        <property type="protein sequence ID" value="MYW27914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="405" mass="43410" checksum="E3CECE552CB9026D" modified="2021-04-07" version="1">MTESDQRRDARPGRRVFVRGAAGVVAAAGLTGTVAVGAASGAPAAASGDERVPFHGAHQAGILTRQQRFGGFAAFDVLARDRAELAELLKKLTARCRTLTAGVTPLDPDVAAVRGPEDRLTITVGVGASLFDGRYGLAGARPPGLVPMPEFPGDRLEPGSCHGDLSVQVCAQNPDAVLHVVRDLARETSGLLRTRWRTDGFLNPPRPEGAPRSFVGFKDGTAHPDTASAREMDRLVWVGPEGPGWSRGGSYQVLRTIRLRAEAWDRVPLGEQERIFGRRKSTGAPLDGRKESDLPDYARDPEGRVTPLDSHIRRANPRSAGSEDSVLLRRSYNIDRGLAPDGTLDVGLVFCCYQRDIARQFATVQKRLEGERFADFSTTTGGGYFLALPGVAGSSDWYGSALLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6I1</accession>
    <name>A0A7K2Z6I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMC family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000058">
        <property type="protein sequence ID" value="MYW27938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="758" mass="83014" checksum="85B73AC227853F12" modified="2021-04-07" version="1">EAVLEWAAIARSAAREHLDIAHTAVAEAENRQLAARRALDAERELARLQERYAKTLRRAEALEERRPEHDRCQEQLERARKADRVAPALELREEAERAYRVASDVLDRTRERLPAELADSGADRLAELEGRFRQELGTLEAARKAEVRSASIDEERVRLNRDARADDEIVREADAWLADWDTTRAELTQRIETAQEAATRAEQLAGQLAPARLRLDAARRRDALATDVQDAREALTAARERALAAHESWLGLRERRLRDIAAELAAGLVAGEPCTVCGSAEHPAPASPGDGHVDRATEEKALAVHRFAEEARTGAEHALTLVRERQAAARREAQGDDSAAPSVAELHSLVDRLSGEHAEARRLAAGTHAAREALAVAEREHAKRVEQRQEARNRTAARTSQREALDREQAGLEGQITAARGESESVAAHADRLSRRVALLADAAEAVRAEQDAAQRRKEADDRLSDAAFRAGFDTPQAAAATLLGGAAQRDLQHRVDAWQAEAAAVADRRTERDAREAAERPAAQAAAAESAHETAEWLLREAASARAAARERCAELDRLSGRAAEEVRRLGPVRQEYERVARLAGLTAGTSADNERKMRLEAYVLAARLEQVAAAATARLQRMSSGRYTLVHSDARTGGRRAGLGLHVVDAWTGSERDTSTLSGGETFFASLALALGLADVVTEEAGGVRLDTLFIDEGFGSLDDQTLDEVLDVLDSLRERDRSVGIVSHVADLRRRIPARLEVVKDRHGSTVHHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Q8</accession>
    <name>A0A7K2Z6Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000067">
        <property type="protein sequence ID" value="MYW27993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="17153" checksum="35B712F57CC3C9A8" modified="2021-04-07" version="1" fragment="single">MLALRLTRGTHPLVLVRRLLVAAASAGVGFLLLCSLGYASAHPASAGSVLRLLWCFVPLAATVMFAVAVARTDPSTRPRPGLSSVGLGPVRLSVLAAVSTAVSTTLGSMVALLFFLHLRGDLTGMPFDGGAAEFLGAGTPLPLAAALMLLALVPVLSATASAVALRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6W2</accession>
    <name>A0A7K2Z6W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_02025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000097">
        <property type="protein sequence ID" value="MYW28080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="151"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="26319" checksum="05ECDFD199190641" modified="2021-04-07" version="1" fragment="single">MATAQASPVRPARAGARRGPLAALRERPAAAKLLLLALAAVILVPLVHSRWGGGIWPDALTADLSAPLGDVTDWIVSNRDNHPLFLYFFGHISNAVVLSVRGVYLVLLALGWAGVTVLAAAVAWRVAGIRLALTAAVSFLACGLLGMWVPTMQTLALMVVAVLASVVLGLLLGLAAGLSDRTFRVLRPVLDTMQVLPAFAYLLPVVLVFGIGVPGAVLATVVYAAPPMARLTALGLRGADGGVMEAVASLGATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6X8</accession>
    <name>A0A7K2Z6X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000095">
        <property type="protein sequence ID" value="MYW28078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="10482" checksum="391BE44A25D756D4" modified="2021-04-07" version="1" fragment="single">REALELAVRHRLTPRAVASVLGLEPVAARELLAAAACEVERTRAALAVVETAGCPTVARLTGDHQVLLSAALRRELVRHVDDCPRCRRAAERVDAAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z726</accession>
    <name>A0A7K2Z726_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000101">
        <property type="protein sequence ID" value="MYW28113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16141" checksum="678AA1901992ED46" modified="2021-04-07" version="1">MHNGEDGMGTGPGDLRRGVGALETFKKRVDALLADLEGSAAGKSKVAAQKVSRASFSGPNARFAEADGLYTQYNRVHESLISLSKSLGDQIEYLSLGVHAAAVGFDNVDDETRRRFHEIQTRMDRQREEAAKSEADNREGQGDGWETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z793</accession>
    <name>A0A7K2Z793_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000111">
        <property type="protein sequence ID" value="MYW28188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="22040" checksum="FFF22026078087FA" modified="2021-04-07" version="1">MTTLIVTVALALAGYLATYLNGVRLAQRQARLARVNLQLSDFYGPLFALMEANSRTYDTFSARHARPDGRDPFDHDIPPTEQELAEWRTWAGTVFIPNIQAMRDVVVTKADLLIEQEMPPALLQLCAHVSGYEITAARWAQGRYEEHLSVIPFPAGELMEYTRDRFTRLKREQAVLLGHTAAEGRWPRLSGRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7A8</accession>
    <name>A0A7K2Z7A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000114">
        <property type="protein sequence ID" value="MYW28202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="177" mass="18503" checksum="14339948C4E5154E" modified="2021-04-07" version="1">AGPSAPAATAEGPKTPSDEITPATGTFTKKQKEYLEDRVPKGMDPAAVLQTGQETCEKLRYLVKVDRDTAVGAIATEEITDAPAAVAGLCPQHQDLVDEAAYAYADGTHAGRTLRPGVYRSASPTTHCSWQIEGTGGKELASGTSDTGKSRKITIPKSARTFTSTGCYAWLAEGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7L8</accession>
    <name>A0A7K2Z7L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="12407" checksum="FDAAE7DC1FE0772B" modified="2021-04-07" version="1">MSERRFKDQDGDTWTEFEPGMLRLTERVGGSSLFVGTEDSIDDVKDAHGPLTEIRPDTDVRALLADVLEELANDVLEDYWDATDPTSERIYGKIAHRIRGRALKLREGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7M0</accession>
    <name>A0A7K2Z7M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="58" mass="6432" checksum="C2E2AA34E9CCAB44" modified="2021-04-07" version="1">MSVDPYGMKTRAVAFAVRAGHNDDMAHRFLERVCADGVLGQTRQYGPLLAEMMTEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7P0</accession>
    <name>A0A7K2Z7P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1998 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000148">
        <property type="protein sequence ID" value="MYW28370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1998" evidence="2">
        <location>
            <begin position="58"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="679" mass="74314" checksum="337C86E78BDFA28B" modified="2021-04-07" version="1">TSAHAKYHRPWCPRRRAADDAARRGERVLLAHELRTDALRLLIPAVTAYTQERLASFKALLLAGIARSYGGDPDHLAVVADSMPEDGGESPLRRHFLVLYDTLPGGTGYLHRLAGRDGLRGVLDHARQVIETCVCVGQGRPACHRCLLRHVTDAEYELVSREHALDMLGELFGRGADRWSTVQVATTRDITLVHQVESELEALFRRGLLEWADRVDEVSVRSALAADGTRDTTLRFTAPDGTVRGWQMETQTPLGFTRPDVVFRSTDDDRRVAVYLDGYRYHAGPGHLTAEADAVKRTRLRAEGWQVFQLTWDDVQAWTGRTAPGADPVWKPYPNTAQKTAMDVHRRMHEGDTRDLTRLVWVNPVETLIGYLTDPDPDAWRLRVQSALAGFAAVSSTSRALADGVETGRRIHEALHGRRLAAGKGAVQVMATRDSSGCPLTIALDLRRGQRGAAWTALTVLDDAPGTVEADEAAHRRRWHAWLYWSNLLQFLDGGEGEGVQLTTGMLSGFDPAELAVTGGAGWLTSQLRAYKPAPDAPEPTTDGRRAPAGPQGRTDGAPPVRDPAWDEVIELLIEDPGLDALAHALADGGVPVPEAGHELGTAAWPAELAWPDRRVGVVLAHRPDPVSGRDIDAEQRDGAYRAAGWQVRTAPEWNADELAALVRGDADTTTNDQGENQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7P9</accession>
    <name>A0A7K2Z7P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antibiotic acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000149">
        <property type="protein sequence ID" value="MYW28374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23833" checksum="AA345B20411E297B" modified="2021-04-07" version="1">MNPGPAPGPADPTVLHPMPGQPRVVQLRPLVTSELIEVGAYSYYDDPEHATEFETRNVLYHYGPERLVIGKFCALGTGVRFIMNGSNHRMDGPSTFPFPTLGGSWADHFDLLTGLPNRGDTVIGNDVWIGYEAVVMPGVRIGHGAIISSRSVVVSDVPDYGIVGGNPARLIRTRYKKADIARLLAVAWWDWPAEHLTRHIRTVMSGTVAELEAAAPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Y0</accession>
    <name>A0A7K2Z7Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000166">
        <property type="protein sequence ID" value="MYW28441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="168" mass="18267" checksum="CB524AC3EB51B76A" modified="2021-04-07" version="1">MSAGKRSAGLLLFRTTGTGGERDVEVLIGHMGGPFWAGREEAAWSVPKGEYGPDEEPAAAARREFEEELGVPVPDGLWLPLGESRQRSGKTVTVWAVEAELEVASVVPGTFTMEWPRGSGVQQEFPEMDRFAWCTPEQAAELLIVGQRVFVKRLRAQVRGEAAASPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8C6</accession>
    <name>A0A7K2Z8C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000212">
        <property type="protein sequence ID" value="MYW28607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="12431" checksum="DF441543EC9811FF" modified="2021-04-07" version="1">PGAPGAPGAPGTPGMPMGGGMGGMGAGGGDKGNGERVRSVLVDAAEESERRNRRRRSSWNRQEDSDTFLTPASRVATTGGDSAEEEQEQSRRPATSADYLEEDVDVWGTEEGGTPAVIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8G9</accession>
    <name>A0A7K2Z8G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_04895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000214">
        <property type="protein sequence ID" value="MYW28621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="26830" checksum="405ADCDCC550699B" modified="2021-04-07" version="1">MYAPERQQEILRLAQESGRVDVLSLAEEFQVTAETVRRDLKALDRAGLLRRVHGGAIPVGRLDFEPDLAERDAVAADEKDRIAQAALAELPADGNVIIDAGTTTARLAAAVPVDSALTVVTHALPVAARLADHPGIALHLVGGRVRHRTRAAVDAWALGAYAEISADVVFLATNGFSPDSGLTTPDLAEAAVKRAVVKAARRVVLLADSGKFGQRHFARFGDLADVDLLITDTGLSPDDARSIESRGTEVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8L0</accession>
    <name>A0A7K2Z8L0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein GT040_05280</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_05280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000246">
        <property type="protein sequence ID" value="MYW28694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026242063.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="66959974"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="250" mass="26628" checksum="A5394532D0D569D2" modified="2021-04-07" version="1">MSGHSKWATTKHKKAVIDAKRGKLFAKLIKNIEVAARSGGVDPDGNPTLVDAIQKAKKSSVPNKNIDSAVKRGGGLEAGGADYETIMYEGYGPNGVAVLIECLTDNRNRAASDVRVAMTRNGGSMADPGSVSYLFNRKGVVIVPKGELGEDDVLGAVLDAGAEEVNDLGETFEVVSEATDMVAVRTALQEAGIDYDSAEANFLPTMQVELDEEGARKIFKLIDALEDSDDVQNVFANFDVSDEVMEKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8N4</accession>
    <name>A0A7K2Z8N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05250</name>
        <name evidence="2" type="ORF">GT040_20335</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000245">
        <property type="protein sequence ID" value="MYW28688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01000964">
        <property type="protein sequence ID" value="MYW31560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510773.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000964.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16736" checksum="AA84E23A3D75FC8E" modified="2021-04-07" version="1">MGVMPLTDMPWWRWRTNVRSALHMLSDPVFHHECWLAGREGYGDVTDAVYRLVEDTWLDNWSAEKYVGTIFRDSAEAAAVDTAALRVLRIMHQVGADAPVSAYLEHHGWPEAVRAAREAHVMLATNDAEDPDIPPRSLDVIRIMTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8R5</accession>
    <name>A0A7K2Z8R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="20735" checksum="17D7216A44632343" modified="2021-04-07" version="1">MTDQATRSETHSDRSEEEIPGKPTAASRTTLSHIMTGSDTNLLGTVHGGVIMKLVDDAAGAVAGRHSGGPAVTASMDEMVFLEPVRVGDLVHVRAQVNWTGRSSMEVGVRVMAERWNESTPGQQVGSAYLVFAAVDGDGKPRRVPPVVPETERDKRRYQEAQIRRTHRLARRRAIKELREKRVADGIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z921</accession>
    <name>A0A7K2Z921_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligoribonuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orn</name>
        <name evidence="3" type="ORF">GT040_05990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-to-5' exoribonuclease specific for small oligoribonucleotides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000259">
        <property type="protein sequence ID" value="MYW28833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="201" mass="22363" checksum="E85C87901ED20F4B" modified="2021-04-07" version="1">MNDRMVWIDCEMTGLSLTDDALIEVAALVTDSELNVLGDGVDIVIRPPDAALETMPEVVRQMHTTSGLLDELAGGTTLADAEEQVLAYIREHVKEPGKAPLCGNSVSTDRGFLARDMQQLEGYLHYRIVDVSSVKELARRWYPRAYFNSPEKNGNHRALADIRDSITELRYYREAVFVPQPGPDSERAKEIAARHVARAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9E0</accession>
    <name>A0A7K2Z9E0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol phosphodiesterase</fullName>
            <ecNumber evidence="2">4.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol diacylglycerol-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphatidylinositol-specific phospholipase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_06635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:17093"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58484"/>
            <dbReference type="EC" id="4.6.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000301">
        <property type="protein sequence ID" value="MYW28957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004436">
        <property type="term" value="F:phosphatidylinositol diacylglycerol-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029797311" description="1-phosphatidylinositol phosphodiesterase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="745"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="843"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="934" mass="99678" checksum="4B8F1F3FD028E2E2" modified="2021-04-07" version="1">MLALALSLSTLTLSAAPAQASDAYNSITSASASNVDWMSRIADGTSLSWLSVPGTHDSLALCGERDPKTGKCGGIATSITQTQENHGFSAQTLTTQFRAGIRALDIRVRVDKGDEGLKFTIHHGAAYQYANFTDVLNATRDFLRDEPDETVLLHLKAECDGGTFGCEDAEGYRTDEWRKKVFDSYLDGRSYTGDGDESTESTAWRDLFWAPSVTGKSQAGQVPSLGEVRGKVVLMGYRATKGGIYDGYGIKQPYPAGGSNEEYVQDAYEVDTISDIAGKWEKVRAHLRKTNGTWDSSRPGEKEYPYKPGALYINYTSGTGGGAHPYTVAGGTPTATGVNSFLRQCLQGENDRCPEFHADRGDKFGGRSGLDRMGVVMMDFPGGKLIDDIIGRNETGGSTRKVMVVGDSMSQGHEGDYTWRYRLWQWFRDQRIAVDFVGPYSGTKPQDTPSAPQPPRLQGEPEPAAGPPRTSGAYAKDAPDFDSDHFAVWGRQAAQDKSLIKEQVAKYQPDLLLVGLGFNDMGWFVSDAGGTLDSMKKLVDEARAAKPNLKFAVANVPQRAKIGGRDDLITKTTAYNKALAEAIPAWHSSSSPVKLVDWAGAYDCAPASCPAAYDGLHPNAVGEYQIAGAFGSTLHKEFGLGSSAPSVPATGPARPSGTPGNVKATSADSGIVVTWDQVFGAYGYEVRSRLAGLPGWSTTRSVGNRFDSTWVADGQKWEYQVRTDNGATNSAWSSTVSATARPRTAAGPVGIVTRPTATGIDFAWGTPTGPYTDSIDRYGVIAYDQDTPGAFVQTVGTRNKALHVDGLKPGHRYTLAVQTWNRAGGGLPALGRPVVVGAGTPPAPTGLKVVSTDATTVQLSWKGSAQAAGYRVWIRNINNGSQSAADESVISETNHGIAFLVPGTWNYEFCMTAVNGALESGKSNCVVAPRPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9H0</accession>
    <name>A0A7K2Z9H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000297">
        <property type="protein sequence ID" value="MYW28915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="388" mass="41468" checksum="D2ED8F2A7A7B12B9" modified="2021-04-07" version="1">MDVRGTVVPGFEPVRDAFVRNFEQRGERGAAVAVYRDGRKVVDLWAGTRDVDGTEPWAVDTVQIVRSAGKGIAAAVPLLLHQRGQVDLDAPVSTYWPEFKANGKERVLVRDLLAHRAGVPALDRPLTPAEAVDGVTGPAAVAAQRPEWEPGTDHGYHAQTYSWLIGELVRRATGRTIGRWIAEEIARPLGLDFWFGLPAEEAHRIGRIGPVEPPAPTEPSGALRVRPKRSVVEAYRDPDSLTRRAFGAIDPLPDENDDAYRTAELPASGGIATARGLAHCYAAMIGPVDGHRRLFAPATLTLARTEESAGPDRVLVVNTRFGLGYMLHGPAAPLLGPGSFGHPGRGGSLGFADPESGIALGYVTNGLQKGVTADPRAQALVRAVRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9X4</accession>
    <name>A0A7K2Z9X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilus assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000359">
        <property type="protein sequence ID" value="MYW29171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="53" mass="5344" checksum="0B422F0A29B5B4E6" modified="2021-04-07" version="1" fragment="single">MDRGRGGGRDRGQVALEYLGFLPLLLLVAMGALQLGLAAYAANQAGTAARAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9X5</accession>
    <name>A0A7K2Z9X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="14554" checksum="646D89087FE39934" modified="2021-04-07" version="1">MDASRELAPFVKQYAVLLSTHRQDGTSVGTPVNIAVEGDHAFIRTFSSAWKVERMRNHPKVELAPCTVRGRPTGPEISAHARLLRPGTKENTHAARMLSRKYPIVQGVLVPLAHRLKRDRTLHYEVWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Y9</accession>
    <name>A0A7K2Z9Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000331">
        <property type="protein sequence ID" value="MYW29085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="52"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="19187" checksum="FD0D714538801AF8" modified="2021-04-07" version="1">TAARVRERGGTIAVGPLRLGPGRGAVAADREGAGFGFWEGRTPPWSIGRGGAPASLELRTSHAFDAAIFYSEVFGWDPHDPGGCEVGYVYQQDTVVVRQGGHTVATLRGGGDGASPDPRLRPQWHVRFRVDDLTAAIEAARKAGGEVSPPTVSPDDGPESMIGDPHGAFFTLTSRRSPAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA03</accession>
    <name>A0A7K2ZA03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000360">
        <property type="protein sequence ID" value="MYW29187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="18556" checksum="8316843A34973D48" modified="2021-04-07" version="1">MPPLVADERTTLESWLDFYRATLVQKCAELPEELLREAAVAPSSVTLLGLVQHAAAVERNWFRRVLVQEDVPRLYAPAGESGSGGGGGGHDGGFELADDATYESAVAVWEEEVRRGRENCAARGLDDTSPFMGGEVTLRWIYTHMIGEYARHCGHADLIRERIDGRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA13</accession>
    <name>A0A7K2ZA13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_07590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23490" checksum="D6F0CA7F3BE929C0" modified="2021-04-07" version="1">MDSATSDRATLSDTADNGLKIVVVGGFGVGKTTMVRSVSEIRPLNTEETMTRAGEAVDHLDGVQAKTSTTVAFDFGRITLDARSVLYLFGAPGQERFWFLWDRLFSGTLGAVVLVDTRRLADSWYAIDRLEHHGTPFIVACNDFGGPLHSEQQIREALDLSEDVPLVECDARDRSSSKYVLITLVEHLAALSAARLSAAEAAVSEAALAAAAPTPEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA68</accession>
    <name>A0A7K2ZA68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000374">
        <property type="protein sequence ID" value="MYW29257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="220"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="600" mass="67459" checksum="FE52E67C0FEABF32" modified="2021-04-07" version="1">MAGRIEDYALIGDMQTAALVCRDGTADWLCLPRFDSHAVFAGLLGTEEHGFWRLGPARPEGDEPLSADRRRYRGDSLILESEWDTPRGTVRVTDFMPPRDGAPQLIRIVEGVSGRVPMRSELRMRFSYGRVTPWVHKVDSRTVAVAGPDSVWLDTEADTYGKNLTTYSDFTVGPGDRVAFTISWQPSHHEPPALPDPEGSLEATELFWREWVDQCTYHGPYREAVVRSLITLKALTYAPTGGIVAAPTTSLPEEIGGVRNWDYRYTWLRDAAITLSSLLRTGYREEARAWREWLLRAVAGDPENLQIMYGIAGERELGEAELDWLPGYENSGPVRVGNGAANQLQLDVYGEVTEALHLAHMTGLTRNDYAMGLQLKLIEYLEKHWEEPDEGIWEVRGPRRHFVHSKVMAWVAVDRTIKLVESGEVDGPLERWYELRDDIHRDVCERGYDKERNTFTQSYGSKELDASLLLIPQMGFLPPDDKRVIGTIEAIQRELSTEDGFILRYPTEGDEAGVDGLAGDEGAFLACSFWMADDLAMIGRVDEARQLFEKLLALRNDLGLLAEEWDSNLQRQVGNFPQAFSHVPLIDTALRLTASGAYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA70</accession>
    <name>A0A7K2ZA70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000359">
        <property type="protein sequence ID" value="MYW29175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="30765" checksum="FC601F4EC0D19F17" modified="2021-04-07" version="1">MLPPTDQQTPTAALLQAPEAQVLELAIGDMHLLLEQHGYVIALYPSGIRPEHERRLHSIRSVLESDRIALVKVDLPPLGVAVLVRQLRQLSICDFSPGVVASAARLLSHYIYAGALLNSVAKLDRVPVSLKSHARSWVPGSQFAVLAGPEPQLIKVGPAAEPLAGPEFRTHLLVAQGQLQSDWVQETLAPAWKVQAVHDTRLPADSARWWGTGRLVEFAAHLPDLSVLYQLVSSVRRERCHWCEMELIGDRCAFCSAPLAAPANRRPSSGVLQLEAGERSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAN4</accession>
    <name>A0A7K2ZAN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000412">
        <property type="protein sequence ID" value="MYW29416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="21611" checksum="256489FA0B5CA672" modified="2021-04-07" version="1">MSRRFRGDAGQAFPIYVVMVAGLLFLAFAFFAVGKASALRNGSQGAADAAALAAAQRARTEMGPGFIASLPGNTLELFLGSTFAPPCAEAERLASANRADKRACYPVYGYLRDRITVEVEGRKPVDSSVIPGTQNTFAKAKATALIEFRCPDWKAVDANSDGVQDLFVFTCSNGRVVEIVPASPPPWSTVSKILFDVRLVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAP9</accession>
    <name>A0A7K2ZAP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_08650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017150">
        <property type="entry name" value="Pept_M20_glutamate_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037238">
        <property type="entry name" value="Carboxypeptidase_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="161"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="358" mass="36471" checksum="1BB931FCDD18CE2B" modified="2021-04-07" version="1">MLEDLRTLVEIESPSRDLDALAASAEAVATVIENRLGGQAVLNVNAGGTHVHWVAGGEPRVLILGHHDTVFPLGTLARRPFAVVDGRATGPGVFDMLGGLVQAVHGLATLDERDRSGVEILVTADEEVGSFSSRAFIEERARACGAVLVFEGAADGGALKTARKGCGAFQVSIAGRASHAGLEPEAGVNALIEAAHQVLDIAALGRPELGTTVTPTVAAAGTLENVVPAEATVVVDVRVESAEEKERVEAAFAALTCHVEGARITVEGSIARPPMPESAANELLSLAQQLMPSIEAVAVGGGSDGNLTAAVGVPTLDGLGAVGGGAHADHEYVVIDAMAERAHLAAGLVKAIQHAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBU3</accession>
    <name>A0A7K2ZBU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RelA/SpoT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_10700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000490">
        <property type="protein sequence ID" value="MYW29735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="5">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="417"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="681"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="759" mass="85033" checksum="EA07A4B2871B3E5D" modified="2021-04-07" version="1">MRARLARLGVQRSSPYNPVLEPLLRTVRGNDPKIETATLRQIERAYQVAERWHRGQKRKSGDPYITHPLAVTTILAELGMDPATLMAGLLHDTVEDTEYGLDTLKREFGDQVALLVDGVTKLDKVKFGEAAQAETVRKMVVAMAKDPRVLVIKLADRLHNMRTMRYLKREKQEKKARETLEIYAPLAHRLGMNTIKWELEDLAFAILYPKMYDEIVRLVAERAPKRDEYLAIVTDEVQADLRAARIKATVTGRPKHYYSVYQKMIVRGRDFAEIYDLVGIRVLVDTVRDCYAALGTVHARWNPVPGRFKDYIAMPKFNMYQSLHTTVIGPSGKPVELQIRTFDMHRRAEYGIAAHWKYKQEAVAGASKVRTDVPKNTGRGQDTVNDMAWLRQLLDWQKETEDPSEFLESLRFDLSRNEVFVFTPKGDVIALPAGATPVDFAYAVHTEVGHRTIGARVNGRLVPLESTLDNGDLVEVFTSKAAGAGPSRDWLGFVKSPRARNKIRAWFSKERRDEAIEQGKDAIARAMRKQNLPIQRILTGDSLVTLAHEMRYPDISSLYAAIGEGHVAAAGVVQKLVQALGGHDEANEDLAEATPPSHGRSKRRANADPGVVVKGVEDVWVKLARCCTPVPGDPIIGFVTRGSGVSVHRADCVNVESLSQQPERILEVEWAPTQSSVFLVAIQVEALDRSRLLSDVTRILSDQHVNILSAAVQTSRDRVATSRFTFEMGDPKHLGHVLKAVRGVEGVYDVYRVTSARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCM3</accession>
    <name>A0A7K2ZCM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000587">
        <property type="protein sequence ID" value="MYW30079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029549947" evidence="2">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="10528" checksum="3D6D5E2A36A4E3D0" modified="2021-04-07" version="1">MPNPRRMSRRAWVLAWAGLCVTGLTATAWLQAAAAPPEARPERHTKAECRDFMPEIEDRMHVAKSNSKGEGSILVVSPPGTDCSDDLHDFLRDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCQ3</accession>
    <name>A0A7K2ZCQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxoguanine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.32" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030562515.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000597.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102127">
        <property type="term" value="F:8-oxoguanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="65"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="462" mass="48835" checksum="553EDAF6572C197E" modified="2021-04-07" version="1">MAASADPQRIVIENCSIATVDAHDTEYASGYIVVADNRIESVGAGKAPEGLTGVVRRIDATGHLATPGLVNTHHHFYQWITRGLATDHNLFNWLVALYPTWARIDEPMARAAAQGSLAMMARGGVTTAMDHHYVFPKDSGDLSGAIIGAAREMGVRFTLARGSMDRSEKDGGLPPDFAVETLEGALAATEATIDAHHDASFDAMTQVAVAPCSPFSVSTELMRQGAELARRRGVRLHTHGSETVEEEQFCKELFGMGPTDYFESTGWLGNDVWMAHCVHMNDSDIAAFARTGTGVAHCPSSNARLAAGIARVPDMLAAGVPVGLGVDGTASNESGELHTELRNALLINRLGAHREAALNARQALRLGTFGGAQVLGRADQIGSLEAGKLADLVLWKLDTLAHSSIADPVTALIFGAAAPVTLSLVDGKPVVEGNHLTTVDEDAIARTTRDEARRLAQIAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCV4</accession>
    <name>A0A7K2ZCV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="89" mass="9883" checksum="91C490F8F8005B5B" modified="2021-04-07" version="1">MKTLNLSWGDRPIRLETEGTRTFLRLGAELRVDVTDASLDQLDRLADVAADLADVRRDRIRAARVADEVAAEDGFRFVGVPYQHGTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD06</accession>
    <name>A0A7K2ZD06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000625">
        <property type="protein sequence ID" value="MYW30261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7194" checksum="53B148877D4C2342" modified="2021-04-07" version="1" fragment="single">MSRETDSSSSGPQGRGGAAYPSGTPPYGSRQYSSPAGSDETPESVDPPRPEEPKTETTLTTRIRINIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD33</accession>
    <name>A0A7K2ZD33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxylacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_13265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000613">
        <property type="protein sequence ID" value="MYW30229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="188"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="314" mass="33930" checksum="04A38D0C96EFC43F" modified="2021-04-07" version="1">MSPHRQRTVTVIGAGTIGLGWIALFLGHGHRVRVNSRRAQAPRIVGEALELFAPFLPPGSADPATFSANLEFVPDLEKAVADADVIVENAPENLELKQELFERIGKAAPKDALILSSTSTLGPDALGARMADSSRLVVGHPFNPPHVVPLVEVVAGERTSPAAVSEAVEFLTSVGRTPVVLRKPILAFAANRLQSALLRESVHLVREGVVSLEELDQVVTQSVGLRWATVGPFLAFHLGGGQGGLRKWLGTLGANLERGWEELGRPPMDEETINSLIEQAEAAYGDRSYEELVRERDTKQTAILRTLAEVSREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD37</accession>
    <name>A0A7K2ZD37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000626">
        <property type="protein sequence ID" value="MYW30263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13544" checksum="6ACFD55264EE294F" modified="2021-04-07" version="1" fragment="single">MTFGFAPSSATSISAFSTPPGGADSVNRLARMLEPAEWASAGIPLLRSPREVVSGLHSRHRPTPATAVVAVLDHEERLTASASFARRDSVAADGWDFRNALLAHLRRVIPHDLRRRTPVRTAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDI0</accession>
    <name>A0A7K2ZDI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000659">
        <property type="protein sequence ID" value="MYW30368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="201" mass="21353" checksum="C668B03BF70B3BE6" modified="2021-04-07" version="1">SREGRSMEDMRLRLLLDTVLDAASGLRRELALPPVTARPADSVDAVEPGRMSPKDIAARALSDTDPALLDQLLALPQAHLIVDGYNVTKTGYPQMPLEKQRLRLLGGLSVLAAQTGAEMTCVFDGAELAAPVLLAPPRGVRVLFSKAGVTADELIRQLARAEPPGRPVVVVSTDREVADGVAKAGARPVASVLLLKRLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDI3</accession>
    <name>A0A7K2ZDI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000667">
        <property type="protein sequence ID" value="MYW30427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="145" mass="15324" checksum="4A02521498FADBEB" modified="2021-04-07" version="1">MTGNEADTAGHVCRPASAAEARREVEFALHPLLCSADSHYLRAHRAGFEDAVLVASELVGHVLHHPEDSPGCFLVCLLHRDEVTITVTDTCEEILPLCPRAPAPGSTGLAGMGWWVINEVADQVVVQTLPTGGKTITVAVPLSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDK5</accession>
    <name>A0A7K2ZDK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000671">
        <property type="protein sequence ID" value="MYW30447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="335" mass="34766" checksum="4EA1453AEB3E519D" modified="2021-04-07" version="1">HHVWRGTLFVVWGAVIALLVGASLTAIGPGWTTARTAALVAAVITAALLTVAARLHRARGGLLAPLIGEDNRLSTSRAVAAAWVLLAVFAVLVLALQLAGASDPDDRDALIEGLDLVRSAGVVAVLALVCAVAVVVRRVVTVRVLGQRLQKLRADRPRAADLLTDDSGRGSFTDVQYVLVSAVAVLFAGVRLARRPEQLPDLPWGLALLVAVSAATYFAGKYAEGGRPVVLSVVRAREAGDLDAPIRTGDDIEIRGAGFVPPGAGSPDRLARLVVRIGTVHVHVPLIPVAGGFANPTDSVLTVPVPVEVEPGTVDVQVVTAAGVETNRCSIDVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE36</accession>
    <name>A0A7K2ZE36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_15375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000721">
        <property type="protein sequence ID" value="MYW30623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="25330" checksum="3EC7FFFC9326D809" modified="2021-04-07" version="1">MSGLIDTTEMYLRTILELEEEGVVPMRARIAERLDQSGPTVSQTVARMERDGLVQVAGDRHLELTEEGRRLATRVMRKHRLAECLLVDVIGLEWEQVHAEACRWEHVMSEAVERRVLELLRHPTESPYGNPIPGLEELGEKAEADPFLDDSMVSLAELDPGAEGKTVVVRRIGEPIQTDAQLMYTLRRAGVQPGSVVSVTESPGGVLVGSSGEAAELDSEVASHVFVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE82</accession>
    <name>A0A7K2ZE82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000723">
        <property type="protein sequence ID" value="MYW30636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="11830" checksum="E8B8D380C18336A9" modified="2021-04-07" version="1">MAKSSRSLPQTFRHYLANPLALGYLGVVLTVCLWVAVDTFSAASSGDASFAGVWAILATAPTSLLFTFLFTFAGPVGLIGIPIGAVAQAFALGALYRHVTERRTHGTANGVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEM1</accession>
    <name>A0A7K2ZEM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000763">
        <property type="protein sequence ID" value="MYW30803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="9223" checksum="C1C7350DB8E3BEBA" modified="2021-04-07" version="1">YDLEHYRDTLRGFYFDFTSRAPGPLIKTSEDLVDAIRNIDEVSEEYQEKYARFRADFCEPSDGRAAARVVDRMLAIGDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEU4</accession>
    <name>A0A7K2ZEU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000768">
        <property type="protein sequence ID" value="MYW30838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="346" mass="37156" checksum="159A4E4E02EE4908" modified="2021-04-07" version="1">MSAAQYPAVSVIMPVLNEERHLRNSVRHILEQEYAGEMEVVIALGPSTDRTDEIAAQLVAEDPRVHTVPNPTGRTPAALNAAIKASRHPVVVRVDGHGMLSPNYIATAVRLLEETGAQNVGGIMHAEGENAWEDAVAAAMTSKIGVGNAAFHTGGQAGPAETVYLGVFRREALERAEGYNVEFIRAQDWELNFRIREAGGLIWFSPELKVQYRPRPSVKALAKQYKDYGRWRHVVARYHSGSINLRYLAPPTAVVAIAAGLVLGATVTPWALLVPGGYLAAIVAGSLPAGKGLSLKARAQIPVALATMHMCWGFGFLTSPRSLAKRVIASRRPSLADSSASSSETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF69</accession>
    <name>A0A7K2ZF69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000814">
        <property type="protein sequence ID" value="MYW31011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="7867" checksum="FD2F701E8AE90DBA" modified="2021-04-07" version="1" fragment="single">MGERVRGRARTWRPAAVVVLLTALTGCSGFLVPAGEGEREPTPTARAATPPPTSVTPPPVADVPAQSPDPSPTPTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF73</accession>
    <name>A0A7K2ZF73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000810">
        <property type="protein sequence ID" value="MYW30982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="7985" checksum="1C44063EDC20F1B3" modified="2021-04-07" version="1" fragment="single">MAALRTGVLGCAGIARRRVLPAMRQYPGIDLVAVASRDPDKARRTAAEAGCEPVHGYDELLARPDIDAVYVPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFD7</accession>
    <name>A0A7K2ZFD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000835">
        <property type="protein sequence ID" value="MYW31074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11701" checksum="EAC403A199579C7A" modified="2021-04-07" version="1">DDVPAVPVAPVAMPAPRPAPAVVPAAEPEFADVDDDQELVLEELTREQVLDWRNRAAADHQLVFDHIDRYGELSAQRLFTRAFVAQVQRLSGLGHLDLGYTTWGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFF0</accession>
    <name>A0A7K2ZFF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000823">
        <property type="protein sequence ID" value="MYW31048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="381"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="591" mass="62106" checksum="C69B77D96FF52955" modified="2021-04-07" version="1">MPDAGAPGTRGDASPRRRRRTIAIATLLVLVVATGTGVAVNGGLLSLSESCEDSAVRLSLAASPDIAPAVRDIAEQAFADEVRSDGHCLDVEVVARDSYKVADALAGGGETPDFQVWLPDSDLWLDRAEWLGTGTPISPSDSVASSPVALAMVPSASKRLGWPKKTYSWAELVGASLRSEKIRLGAADPARSATGLLALTSIGGSSAQQGGDSDTRVAETAKVLAERMSDSDARVLETLARSGSGAEEGNPRRNQAVLISEQAAFTHNAEATGSGRLNLFYPEDGTPLLDYPYTLVDEEKLTLAQSRAALRFMTLLNDRSSRAVFARYGCRPADGAAEDAVVTSAGGRSPQPYATSAAEAPSAKQLQEMLGMWTITVQSARLTTVVDASGSMATLVPGRGQSRMDVTKESLIQALGQFTPDDEIGLWEFATTLDGEKDYRQLMETRRLGDPAQGGSTHREKLSAAFAGLQPVPGGATGLYDTTLASYKEAQATYVKGKFNALVILTDGSNQDEDGISRSALIAELKELADPERPVPVIAIAVGPDADREEAAEIARITGGDGYEVSDPAQIQAVILQAIMTAGQNGRAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFM4</accession>
    <name>A0A7K2ZFM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000861">
        <property type="protein sequence ID" value="MYW31174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="23483" checksum="C9832F84275D2D0D" modified="2021-04-07" version="1">DWEYPNACGLTCDTSGPAAIKTMADAMRAKFGPNNLVTAAITADGSSGGKIDAADYGGAAQSFDWYNVMTYDFFGAWAAKGPTAPHSPLTSYTGIPQQGFTSADAIAKLKAKGVPAKKLLLGIGFYGRGWTGVTQAAPGGTATGAAPGTYEAGIEDYKVLKSTCPATGTIAGTAYAHCGTNWWSYDTPATIGSKMAWAKSQGLGGAFSWEFSGDTTNGELVSAISNGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFP2</accession>
    <name>A0A7K2ZFP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_18015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 7"/>
    <dbReference type="EMBL" id="WWKE01000856">
        <property type="protein sequence ID" value="MYW31119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="475" mass="52991" checksum="DC9EFEBEC0D96F8C" modified="2021-04-07" version="1">MPLHRGAHPQRDEHSEERRRLALNPFFGEADPTAAMNTAPPRHRLPDGPLPPLTAYRLVHDELMLDGNSRLNLATFVTTWMEPQAGVLMGECQDKNMIDKDEYPRTAELERRCVAMLADLWNAPDPSTTVGCSTTGSSEACMLAGLALKRRWSQRNADRYPATARPNLVMGVNVQVCWEKFCNFWEVEARQVPMDGERFHLDPQAAAELCDENTIGVVGILGSTFDGSYEPIADLCAALDALQERTGLDIPVHVDGASGAMVAPFLDPDLVWDFRLPRVSSINTSGHKYGLVYPGVGWALWRTADDLPEELVFRVNYLGGDMPTFALNFSRPGAQVVAQYYTFLRLGHDGYRAVQQASRDVACGLAREVEELGDFRLLTRGDELPVFAFTTNPDVHAYDVFDVSRRLREHGWLVPAYTFPANRQDLSVLRVVCRNGFSSDLAALLIEDLKLLLPELRAQKHPLSHDRGVATAFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFU7</accession>
    <name>A0A7K2ZFU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000869">
        <property type="protein sequence ID" value="MYW31247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="18256" checksum="8302B6EE4F054E8D" modified="2021-04-07" version="1">MNSANMLAEAFDRVAEAVHAAAEGLSADDLNARIDDGANSISWLIWHLTRVQDDHIADAAGTGQVWLTKGWAERFGLPFDEEATGYGHSGDEVAAVRVDSADLLLGYYDAVHEQTLGFVRGLDGRALDRSVDEAWSPPVTLGVRLISVIAEDLQHAGQAAFVRGVRERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFW3</accession>
    <name>A0A7K2ZFW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_18720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000870">
        <property type="protein sequence ID" value="MYW31253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509661.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000870.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="22772" checksum="125B1D90ACB2D538" modified="2021-04-07" version="1">MNKAQLVEAIADKVGGRQQAADAVDAVLDAIVRAVVAGDRVSVTGFGSFEKVDRPARYARNPQTGERVRVKKTSVPRFRAGQGFKDLVSGSKKLPKNDVAVKKAPKGSLSGGSSAARTTVKAAAAKKSAAKKATAKKATATKAVAPAKKTTATAKKAAAKKATAKKATPAAKKATPAKKATATAKKASPSKTAPAKKATAKKAPAKKTTARTTTAKKATARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFY0</accession>
    <name>A0A7K2ZFY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000868">
        <property type="protein sequence ID" value="MYW31236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="201"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="463" mass="49799" checksum="AD0D37828C99E9F4" modified="2021-04-07" version="1">MSETPDSAVRTYTEQHRAAFLDDLAEWLRIPSVSAQPEHDGDVRRSAEWLSAKLKETGFPVTEIWETPGAPAVFAEWPSEDPDAPTVLVYGHHDVQPAAREDGWATDPFEPVIRDGRMYGRGAADDKGQVFFHTLGVRAHLAATGRTTPAVTLKLLIEGEEESGSPNFRALAEQHAARLAADAVIVSDTGMWDEETPTVCTGMRGLAECEIELYGPAQDIHSGSFGGAVPNPATEIARLVAALHDEDGKVAVPGFYDGVTDLTDTERALFAQLPFDEATWLRTAKSQAASGEAGYSTLERVWARPTAEVNGIGGGYQGAGSKTIIPSSALVKISFRLVDGQDPDRVQESVRAWVESRVPAGIRHRIAFQPATRPCLTPLDHPALQAVARAMGRAFGSKILFTREGGSGPAADLRDVLGAPVLFLGISVPSDGWHAPDEKVELDLLLKGVETTAYLWGEMATAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG12</accession>
    <name>A0A7K2ZG12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000867">
        <property type="protein sequence ID" value="MYW31229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="16406" checksum="0541BA4F23261DB7" modified="2021-04-07" version="1">MRGVLIGALGGVVVLGITAAVVVPEAREWYDGRHEQTSSYATGKAAKADRDSVPSWLPDDAASVEYAMRTTGGERILKATLNGDQLPGSCEPLRGKKAPDPEISASWFPSDRAGEARGRCGSYYVSLEGHTLYAWQTNGDWMEENRRSSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGG5</accession>
    <name>A0A7K2ZGG5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endopeptidase La</fullName>
            <ecNumber evidence="3">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="5" type="ORF">GT040_19775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000922">
        <property type="protein sequence ID" value="MYW31453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="4">
        <location>
            <begin position="443"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="576"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="639" mass="69004" checksum="5CAEB1A276FEC532" modified="2021-04-07" version="1">AANSGYSPFVTTAQKVQLLETVDPVVRLKLATQWLSEHLAEQDVAESIAKDVQEGVDKQQREFLLRRQLDAVRKELSELNGDPEDESDDYRARVEAADLPEHVRTAALKEVEKLERSSDQSPEGSWIRTWLDTVLELPWTERTEDAYDIRGAQEVLDAEHAGLADVKERITEYLAVRKRRADRGLGVVGGRRGGAVLALVGPPGVGKTSLGESVAHAMGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAIKEAGSMNPVVLLDEIDKVGSDFRGDPAAALLEVLDPAQNHTFRDHYLEVELDLSDVVFLATANVLEAIPEALLDRMELVRLDGYTEDEKVVIARDHLLPRQLERAGLEKDEVALEESALRKLAGEYTREAGVRNLERAVARLLRKVAAQHELGDRELPFTVTDADLRGLIGRPHHVPESAQDPAERRTAVPGVATGLAVTGAGGDVLFVEASLADPETGASGLTLTGQLGDVMKESAQIALSFLRSHGAELELPVADLKDRGVHIHFPAGAVPKDGPSAGITLTTALASLLSGRLVRTDVAMTGEVSLTGRVLPIGGLKQKLLAAHRAGITTVVIPQRNEADLDDVPAEVLEKLDVHPVTDVRQVLEIALAAASAPAERIPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGG6</accession>
    <name>A0A7K2ZGG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_19665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000916">
        <property type="protein sequence ID" value="MYW31432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="85"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="21101" checksum="DC99E9B467F3C021" modified="2021-04-07" version="1" fragment="single">MDERSRYEAVSSRDARFDGAFFFAVVTTGIYCRPSCPAVTPQRANVRFYPTAAAAQAGGFRACRRCRPDAVPGSAEWNVRADVVGRAMRMIGDGVVDREGVPGLAGRLGYSARQVQRQLNAELGAGPVALARAQRSHTARVLLQTTGLPVTEIAFAAGFASVRQFNDTIRRIYARTPSALRAEAGTGLGGGPATGLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGR2</accession>
    <name>A0A7K2ZGR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="3">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000945">
        <property type="protein sequence ID" value="MYW31532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6276" checksum="3188C42D4CD40928" modified="2021-04-07" version="1">VVARADLLRALPGSGTDEHAVETAMARLRSALGAPRLIQTVVKRGYRLSLDPAGDTPGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH91</accession>
    <name>A0A7K2ZH91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001002">
        <property type="protein sequence ID" value="MYW31720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509889.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001002.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="34775" checksum="E3C8A0822A65E47A" modified="2021-04-07" version="1">MSDPSSPFGFELVRRGYDRGQVDDRITKLVADRDSALARITSLEKRIEELHLETQNAQAQVNDAEPSYAGLGARVEKILRLAEEEAKDLREEARRAAEQHRELAESAAQQVRNDAESFAAERKSKAEDEGVRIVEKAQGEANTLRSDAQKDAQQKREEADALFEETRAKAAQAAADFETNLAKRREQSERDLASRQAKAEKRLAEIEHRAEQLRLEAEKLRTDAERRARQTVETAQRQAEDIVADANAKADRIRSESERELAALTNRRDSINAQLTNVREMLATLTGAAVAAAGSPVDDEPAQRGVPAQQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHL9</accession>
    <name>A0A7K2ZHL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001027">
        <property type="protein sequence ID" value="MYW31851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029915538" evidence="2">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="13782" checksum="7E256ADFB1A81C68" modified="2021-04-07" version="1" fragment="single">MRSTRLLCGASLAAALVVPVAAPAQAGPPSRTPAAFPAADGAKGQELPGMPTALDPRAEAVTCTPASKERAKKQDWSRQRLDLDRLHRHTTGAGVTVALISTGVDPGAEGLDGRVTADGEAADDCVGQGTFLAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHN3</accession>
    <name>A0A7K2ZHN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001030">
        <property type="protein sequence ID" value="MYW31860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="54" mass="4252" checksum="D38AA0A2C33E183B" modified="2021-04-07" version="1">GGAAAGGGGWWVGGSGGSSCSSSSGHSCGGGSSGHSCGGGSSCGGGGGGCGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHV3</accession>
    <name>A0A7K2ZHV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF2156 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_22225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001059">
        <property type="protein sequence ID" value="MYW31917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_2_TM" evidence="9">
        <location>
            <begin position="27"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="8">
        <location>
            <begin position="251"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW31917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="607" mass="67463" checksum="AC1D0D8D20B98427" modified="2021-04-07" version="1">MGDVRSAEEAARHSTARSRRSAVFAIWYLRVVSFINFLSAVWVTLGQDLRRHNTENYFTPYLLTAGFSSGVIALFLAVTMRRRKRAAWIVNMVLGGLVLVAYLLAFFFAEIRQHAQNWVSLALTAAFVVALVLGRREFYAKGDRSNPKLAALVAVVGLLVTSLVATALVTVTNTAHDDYRSTFLDRWRYGALRLISVAADDSRFPGITTPGWVNVVINILSTLLLIAVVYAAFRSRRAVDPLSPEDEAKLRALLDKHGDRDSLGYFSLRREKSALWSPTGKAAVVYRVVGGVSLASGDPIGDPEAWPGAIEPWLAEAREHGWIPAVMGASEEAGTVYARHGMDALELGDEAIVETADFTLDGRAMRGVRQAYNRVKRAGYEVTIRRHADIPEAEMAELVRRADDWRDGETERGFSMALGRLGDPADGQCVMLECRNASEGGKPGKGDTKKPDRTQAPGELRAVLSFVPWGPHGLSLDLMRRDREAENGLMEFMVIQLLQRSGEIGITQVSLNFAMFRSVFERGSRLGAGPVLRLWRALLSFFSRWWQIESLYRANAKYRPIWEPRFMLFEKSADLARISLAAGRAEGFLEAPGLPKWLHRARLGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI24</accession>
    <name>A0A7K2ZI24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_22685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001065">
        <property type="protein sequence ID" value="MYW32003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="140" mass="15475" checksum="3677CBC9D17EC82D" modified="2021-04-07" version="1">MLTITQALHDQIVAHSRADHPDEACGVVAGPAGTGRPERSIPMLNAARSPTFYEFDSGDLLKLYREMDDRDEEPVVIYHSHTATEAYPSRTDVTYANEPGAHYVLVSTADTDGAGPFQFRSYRIVDGEITEEDVQVVEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI58</accession>
    <name>A0A7K2ZI58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001067">
        <property type="protein sequence ID" value="MYW32024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="79"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="349" mass="37063" checksum="538D7A194DF0F657" modified="2021-04-07" version="1">MNSSEEIAVSGISAGRSAMRMGPAELVQAAAMARRFYLEGKSKIQIAEEFGVSRFKVARVLETALERDLVRIEIRVPAELDAERSDALRARYGLRHAVVVESPAEEQEDAPDPENLGEVAADLLGELVAEGDVLGLAWGRSTIHMAAALDRLPPCTVVQLTGVYDAGTAERGSVEAVRRAAQVSGGEAHPIYAPMLLPDPATAAALREQTGIARAFEYFDKVTVAAVSIGSWEPGISTVHDMLSDKERAHYASLGVAAEMSAHLFDSDGRRVGRDLGERCITVEADRLRRIPEVVAIAGGLRKAAAIGAVLRSGLVTSLVTDTAAADYLLTESAAGVRPALERADPDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI64</accession>
    <name>A0A7K2ZI64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001066">
        <property type="protein sequence ID" value="MYW32018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="14339" checksum="C48290632C3E5014" modified="2021-04-07" version="1">MKKCTAVALFDPPDWIVALFASEHRLETRHLLCELGEDHDDDHAAMLWEEGGRLGSAVWARWAGKNMRLASLGWCTALTPKEEACGLFDDHPSAHAWDVTDPTLEALKRELAKDLPDLFPEYGEGHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIR5</accession>
    <name>A0A7K2ZIR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001113">
        <property type="protein sequence ID" value="MYW32215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bact-PGI_C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13153" checksum="2EDD7C8053C2E944" modified="2021-04-07" version="1">PVGRRFAAVLSELAGRPALAAQLPEALPSHGTLLAGDFAAGADPDDFFRDRVDEGETLRARVVLLRDRPTGGLSAYPAARELALGHDTPISELEPDEGSELETLAELLAITDFAAVYLSLASTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIY3</accession>
    <name>A0A7K2ZIY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001114">
        <property type="protein sequence ID" value="MYW32229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="28581" checksum="2E7E69C77986A8E6" modified="2021-04-07" version="1">MESLRIIDTWPVPTAAAAVVRADGTVLGTHGPTDHRFPLASVTKPLAAYAALVAYEEGAVELDEPAGPEGSTVRHLLAHTSGLAFDEHRVTAPPGNRRLYSNAGFEVLGDHIAKASGIPFAEYLRQAVLEPLSMTSTTLDGSPARDGVSTVDDLVRFAAEVQAPRLLDPRTVLEAQSVVHPGLKGVLPGYGHQSPNDWGLGFEIRDSKSPHWTGASSSPATFGHFGQSGTFLWIDPVAGVACVALTDRAFGPWAAEAWTPFTDAVLSEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ26</accession>
    <name>A0A7K2ZJ26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001152">
        <property type="protein sequence ID" value="MYW32348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016676">
        <property type="entry name" value="P_lipid/glycerol_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016753">
        <property type="entry name" value="P_lipid/glycerol_ac_tran_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="143"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="356" mass="38619" checksum="8638E83B8593BD0C" modified="2021-04-07" version="1">MADAKVIPFDDDRSRSGGGSRPARRRTGGGSGGRGDGSTAPVSALPGGRLPDDPLEGAADPQEPQRPQESPVREAGDGGWDRRIAGGLAFLRRRVTGDYEVDEFGYDKELTDQVLMSALRPLADKYFRVEVKGIENIPSEGGALIVANHSGTLPLDGLMLQVAVHDNHPAERHLRLLAADLVFHLPVVNELARKAGHTLACAEDAQRLLELGEIVGVMPEGFKGIGKPFGDRYKLQRFGRGGFVSTALRAGAPIVPCSIVGAEEIYPMIGNAKTLARLLGFPYFPITPTFPWLGPLGAVPLPTKWTIQFGEPIPTDGYPPEAAEDPMLMFNLTDQVREQIQHTLYKLLVQRRSVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ79</accession>
    <name>A0A7K2ZJ79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001159">
        <property type="protein sequence ID" value="MYW32402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6144" checksum="C4F14312B05805B7" modified="2021-04-07" version="1" fragment="single">MTSTAPHTPHDPPPGTSAGPAAVALTDVHKTYGTTRAVDGVSLTVGRGEFFGLLGPNGAGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJC5</accession>
    <name>A0A7K2ZJC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001172">
        <property type="protein sequence ID" value="MYW32441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="25869" checksum="DCACEA07F7073F57" modified="2021-04-07" version="1" fragment="single">MIDYTHPARKGGRDSDLAAALHAAEDHAGRLVQRGAHAGSDPAAELNDWYGTVQTVADACASTLALGNVPPPDEARTLDTWLLRATACLGACRRLLREARHLTEPPLTDAEVRDTYLALLDLTHVVHESADHIRRSLAARRDGIPPQEAPERFVRSRIGHQDLMRRALRLLPEEDARRDEWMFRYVVLAQRVAEYGGESPGEVEAARATAAELARPGSRLDDDQRALLRAAGAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJK2</accession>
    <name>A0A7K2ZJK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="316" mass="32896" checksum="F1A260992AAAB082" modified="2021-04-07" version="1">MSRATREAYRDSLLPLLQQHPELICLDTDTGLFSAEHAAAAGEQYLNLGIAEHNLMGMAAGLAACGRVPFVNTMAAFAASRALEAIKIDIAYNRLPVRIMATHGGLAAGHLGPTHQALEDLAVLRVLPGMTVVVPADAAATEAFVEQSLGLSGPLYVRLGRKPTPPLPAAPAPVIGQAQTLRQGEDVVLACCGPYPVLACLAAAEALAGHGIEATVLNLHTLRPLDTRTLVAAARPAGLVVTVEEHWRSGGLGGAVAEALAEAAPTRVLRLGVPDRFVDAVGNQEHLVAHYDLTAERVVRTVRTALDTAALSGATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJN2</accession>
    <name>A0A7K2ZJN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029586946" evidence="2">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="10199" checksum="838FBC5CFE3382D0" modified="2021-04-07" version="1">MKIPIPAPRWQLVGALVGTVLLASAPAASAAAPSEVSPRQAQTAREGGTPAGPLALYRGIQGGNLCLLARCTVGQSGPGGHTGPSNTQGFNLCLLALCTVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKG5</accession>
    <name>A0A7K2ZKG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001257">
        <property type="protein sequence ID" value="MYW32825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="12579" checksum="A1456DD49716BD4B" modified="2021-04-07" version="1">DRPRLVAVQAEAVSPLAEAFRAGAEDLLPTGSGAPAPTLAEGIAIPRPPRARQILAAVRGSGGTFLTVSEDEIRDAQRDLAARGFYVETTGVACWAAVRDDAARGPGSVVVPLCGAGVKTGMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKS7</accession>
    <name>A0A7K2ZKS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_27680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001297">
        <property type="protein sequence ID" value="MYW32951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="445" mass="46284" checksum="2AC9FA6492B5AD74" modified="2021-04-07" version="1">MWCRVKPPRTTPPAKDYSTPLKKTLTTSLLYFFILGDVLGAGVYVLVGQVAAESGGAVWASLLVALCLALLTAASYAELVTKYPRAGGASHYATLAYGPFLGFLAGFCMLAAGIVSVAALTRGFGGDYLSEFITLPVALVTILFLTALALLNARGIRDSTRANVVATVIEVSGLLLVVGLGVWIVLRGNGDIGRLTDLGTSREGPVAAVLSGAVLAYYSFVGFETSVNVAEETRDPRRSYPRALFGALLTAGAVYVLVGVAAAVAVPTGELTESSGPLLEVVRAAGGVPTELFSAIALVAVANGALLTGIMSSRLAYGMARDGLLPRFLTKVLPGRRTPWAAIATTTALSLLLALTGDVSTLASTLVLLLLVVFFLVNTSLLVLRRDTVSQDHFRAPTLVPVLGALSCVLLATQIERDVWLRGLLVLAVGAGLGAIAAVRSRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLE8</accession>
    <name>A0A7K2ZLE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Abortive phage resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001348">
        <property type="protein sequence ID" value="MYW33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018891">
        <property type="entry name" value="Abortive_phage_infection"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10592">
        <property type="entry name" value="AIPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="669" mass="74412" checksum="3A4CE8E9AA64054D" modified="2021-04-07" version="1">MPDFDLSAYSRDLVADVQANADAERTTTPEAFTRKVLDDLEEAGIAANTFTAYHMAHGHLVHGYGVGESGECLDLFVTDFHLDPLESKLSKNDTETAFRRLLSFIRRCRDGLRRDIDPSFDVYDMCTAVEKALTEVRRIRLFLLSNRVSTGAAVPPTEFDDLPVTHEVWDLARLHRHATSGSVSEPIVVSFDPPLPCVSAPSSDPDHSVTMAVIPGQRLASLYGEYGPRLLELNVRSFLQARGAVNRGIRDTLLNAPGKFLAYNNGITATAAKVEFVHGPDGRPTGISRVHGMQVVNGGQTTASLHYAESRDKADLSNVSVQMKLTEVSPERLPEIVPLISEYSNTQNRVTLVDFSSNHVYHVAVQQITRSLWAPATDGSGQETHWFYERARGQYTDAVAQARTPARQRAFRMLNPPRLKFTKADLAKYVNSWNQLPFQVSRGAQKNFSAFMVRIDEVPPHVNVQYCQRAIAMGILFRAVDRVAASHEAGSYKSMITTYTLARLSLATNCRIDLDRIWREQTISPALETAIDDLCPRVMRVVTSPREGNHVGEWAKKVACWDAVSKIRWAVPRSLEEELREDPLDEEALAGGTGVREGASDEVAAVPADEWYAVEQWAKETRNLEPSQRQLAEFVGRRLELGQEIPEPQAVQALHVRNEALSLGFTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLM8</accession>
    <name>A0A7K2ZLM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_29300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001358">
        <property type="protein sequence ID" value="MYW33251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="385" mass="41268" checksum="BF9FD36F0E28E8FD" modified="2021-04-07" version="1">MSSPDPQVRAARNLTDPPPESTPEKKRPRSPRNRGPVVAVTGAATGVGELLTARLAASDEVKQVIAIDERRGEVSEATWHILDVRDPAIAEKLRGADVVVHLALDLDLETDPAARTAYNVRGTQTVLTAAAAAGVHRVVLCTSAMVYGALPDNDVPLSEDAELRATAEATGVGDLLEIERLGRRAPRAHPGLNVTVVRPTVLVGGTDTALTRYFESPRLLVVAGSRPTWQFCHVDDLVTALEYAALEKIDGEFAVGCDGWLEQEEVEELSSVRRMELPSAVALGAAARLHRIGLTPSPAGDLAYTMHPWVVSVSRLHDVGWRPQWTNEEVLGALLEEVEGRHTVAGRRLGRKDATAVSATAAGATVALLGTAALVRRARKARRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLU8</accession>
    <name>A0A7K2ZLU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001377">
        <property type="protein sequence ID" value="MYW33333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="19777" checksum="714379B06B2813EE" modified="2021-04-07" version="1">MQRGLVHALAWSLATGAAVTLSWWGVHTVMTGTAYDPPRAVPISVGAGAPQRIGQSTEDPLVSSTHRSSPSPSPSPSPSADSDSASPSPSAARPSRTPSSAPAPPPASPKPAANSGEVKGYRTDGGRVVFELGKSSAKLVSATPEPGWSMQVWTNDAWIRVDFSDGGGVDGKTYSVFCTWNGTPPTVQVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMH4</accession>
    <name>A0A7K2ZMH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_30430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001399">
        <property type="protein sequence ID" value="MYW33469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029596702" evidence="1">
        <location>
            <begin position="34"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="54"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="170"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="563" mass="60243" checksum="3375A1E10A131600" modified="2021-04-07" version="1">MTSRHIPSPSRRTVVRAAAATAAAVPVLSATAAASASPSTGSSRAAAPAPAFLHGVASGDPLPDGVLLWTRVTPEPGAEPGSGRGADTPVRWEVAEDREFTAPAGSGTTLASAASDHTVKADVRGLRPATSYYFRFTAGGGAGEGAEVRSPVGRTRTAPATGANVAGLRFGVVSCANWEAGWFSAYRHLAARGDLDAVLHLGDYLYEYATGGYPTQGAALREHRPAHEILNLADYRLRHGTYKTDTDLQALHAAHPVIAIWDDHEFANDAWSGGAQNHTPGTEGAWAERVAAAKQAYFEWMPVRASTEGTVHRRLRFGRLADLHLLDLRSFRSEQASIGNGAVDDPERTITGRAQLDWLKAGLAGSDAVWKLVGTSVMISPVAFGALPAHLLGPLTGLLGLPKEGLAFSVDQWDGYTDDRKELIGHLRDRGIRDTVFLTGDVHMAWASEVPVKAATYPLSPSAATEFVVTSVTSDNLDDILRVAPQTVSTVASAAVRTANRHVKWVDMDSHGYGVLDVTDERSQMDYYVLSDKTAQDATSAWVRSYRTRRGTQKVERVDRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN97</accession>
    <name>A0A7K2ZN97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3459 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_32220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001482">
        <property type="protein sequence ID" value="MYW33810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="19"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="533" mass="59366" checksum="0A1AFE5B1E358A72" modified="2021-04-07" version="1">MEGSQLAADDWWRSAVIYQVYVRSFADGDGDGTGDLTGVRSRLPYLAELGVDALWFTPWYLSPMADGGYDVADYRVIDPAFGTLAEAEKLIAEARQAGIRTIIDVVPNHVSDQHVWFQAALAAGPGSPERELFHFRPGRGEDGELPPNDWESEFGGVPWTRTEDGEWYLHLFATEQPDLNWAHPAVRQEHEDVLRFWFERGVAGVRIDSAALVAKDPALPDLAGHPGPHPYVDRDELHDIYRSWRAIADEFDGIFVGEVWLPDSERFARYLRPDELHTAFNFSFLSCPWDGERLRRSIDETLAEHAPVGAPATWVLCNHDITRTVTRYGREDTSFAFTAKAFGVPSDPELGTRRARAAALLSLALPGSVYLYQGEELGLPEADVPLDRIQDPMYFRSQGRAPGRDGCRTPLPWAADEPYAGFGSTVEPWLPLPADWSSRAADLQATDPGSMLSLYREALRQRRSLPELHTGQLRWLSEERDVLVFARGATLVCVVNLAETPAELPAHTGVLLSSNPLDEDGRLPKDTAVWLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNN2</accession>
    <name>A0A7K2ZNN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Redox-sensitive transcriptional activator SoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">soxR</name>
        <name evidence="9" type="ORF">GT040_33015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001504">
        <property type="protein sequence ID" value="MYW33963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01110">
        <property type="entry name" value="HTH_SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
        <property type="entry name" value="Redox-sen_tscrpt-act_SoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
        <property type="entry name" value="PTHR30204:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01950">
        <property type="entry name" value="SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="18281" checksum="FE1D3F51BA5D713C" modified="2021-04-07" version="1">MPQIPQTLHELSVGQLSARSGAAVSALHFYESKGLISSRRTSGNQRRYSRDALRRVAFVRAAQRVGIPLATIRDALAALPEERTPNREDWARLSEAWRRELDERITQLHRLRDHLTDCIGCGCLSLETCVLSNPDDISGDRITGSRLMPERRQQPAEEQEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNZ3</accession>
    <name>A0A7K2ZNZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_33465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001539">
        <property type="protein sequence ID" value="MYW34050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029900722" evidence="3">
        <location>
            <begin position="30"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="121"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="5">
        <location>
            <begin position="430"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="560" mass="60228" checksum="346CB2237420A7C2" modified="2021-04-07" version="1">MRRRRLVPLLAVSLTATLAPALATSTANAAPAAAAPSVASSHAAPRSAALPSAVLPPAAQGAALDRYTKQKPRWKRCASTAPAEFQCATIKVPLDYRAPGGKRIDLAISRIRTAEPGKRHGVLLSNPGGPGGSGTYMPLALREELPKSVLRKYDLIGFDPRGVGESSPVTCGLTPEEEEWLRPYKEETFAKDVAWARKVADKCRAKAGATLPHITTRNTARDLDLLRAVLGEKKISYLGYSYGTYLGAVYTQLFPGRADRFVLDSAVDPALAWRGMVQWWAWGAEPAFDRWTGWAAARSETYGLGDTPKKVDRTFWELVARADRKPVELDGLLLTGDDIRIGMRAAVFSPQTATEAFVELKKAADGQPAAARKLTAFTGTTGAARTAADVPADNMTASFWAVVCGDNSAAWPRNPERYRQDAIADKGRYPLFGDFASSIKPCAFWNPSVERATVVNNKAGSLIVQNEWDSQTPLPSAQALHQDLKRSRMVTVLGGEGHGVYPSGNACTDGTVTGYLLSGKLPAKDVTCRATAASNADARQNRKGDELPGSPLPERAPDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP41</accession>
    <name>A0A7K2ZP41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001543">
        <property type="protein sequence ID" value="MYW34100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Peptide/Ni-bd"/>
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        <property type="entry name" value="SBP_5"/>
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        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
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        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="29"/>
        </location>
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            <end position="556"/>
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    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="83"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="556" mass="60871" checksum="4F74650AE35118C7" modified="2021-04-07" version="1">MRIFKSRTVRAITTAVAVGLIATGCSSERDEGGAKGGDKDTFVFAGSGDPGSLDPALAGDGETFRVTRQAFEALLEHEPGGSKLVGGLAESWESDPSGKVWTFKLRQGVKFHDGEAFNAAAVCANYDHWFNWKGTYQSSAVSYYWQKIMGGFAKNEDAEAPKPNYKSCTAKDENTAVIEVNETTANLPGGFSLQSLAIHSPKAIKEYEKQDASAKGDAITYPKYSQEAGTVAGTGPYKIVKWNKGNKEVSLERFDDYWGDKAKVKNLVFRTISTEETRRQALQAGDIDGYDLVSPADVTTLEKQGFVVPTRDVFNIFYVGMTQSANPALKKPEVRQAITHAIDRENLVKTQLPEGGKVATQFMPDTIAGFSDQVKTYPFDTAKAKDLLKQAGEEKLSVEFCYPTEVTRPYMPAPQDLFELMKADLEKAGITVKPKAMKWAPDYLDAVEVGSCALHLLGWTGDFNDGFNFIGTWFSKHDKQWGFKDQKVFNAVNAASKVADTSSRTEAYKKANEAIMEYVPGVPISSSPPAIAFAKNVNPPKVSPLTQENFAEVSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPH2</accession>
    <name>A0A7K2ZPH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001584">
        <property type="protein sequence ID" value="MYW34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="12"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="31130" checksum="70F3F8D0F9895CB3" modified="2021-04-07" version="1">MELNASYTSLVAVGDSFTEGMSDLLPDGTYRGWADVLASRLASRSPGFRYANLAVRGKLISQIVDEQVGAAAAMQADVVTLVGGLNDTLRPKCDMGMVRGRLEEAVERLAPSCKQLVLMRSPGRNGPVFDRFRPRMEALFALIDDLAGRHGAAVVDLYSAPSLSDPRMWDADRLHLASEGHRRVAEAVWQTLGLPPELDWQAPVPASLPPHWANRRADDIRFARRHLGPWIGRRLTGRSSGDGRWGAQFDPGTASGFWITPADAEAPGPVTGWRRASPEEGASPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPM9</accession>
    <name>A0A7K2ZPM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001568">
        <property type="protein sequence ID" value="MYW34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="14438" checksum="4F1B9766E6AA1A68" modified="2021-04-07" version="1" fragment="single">MPHWKALPEEIDPHIREFASQLRLIVERSGLNITALADRTGFDETSWERYLSGRNLPPRRAVVALADATDTPQHHLTAMWELAERVHSFDAYGSDAYGSDAYGSDPYRPDPHDSDPHRTDGRAPFVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPS6</accession>
    <name>A0A7K2ZPS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001602">
        <property type="protein sequence ID" value="MYW34366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029908885" evidence="2">
        <location>
            <begin position="40"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="401" mass="42496" checksum="A258B82630782A77" modified="2021-04-07" version="1" fragment="single">MEYPLPPEPGPMSPGRARRAVRVVAFVLAALSVLTVALTSTVRATVLSPGYYRSVLDEESAYDRLYSEVLVDPAIAPVTRDLLAHLPVPEALVTSNIKVVLPPETVRSLTDQQIHALTGYLRGDTDELRLNVDIDPVMRNLAELARIYFGDLVAGLQDQEEPDFARFTDDLTGALEALREGRAPTLPALPLTDDQAARATDALLILVPEQDRAELRPDVEVALGRGDVSTALATTAAAALADGSRTAAADLRTTLQGGTWDLTAALTAAGNDLDALEQARERVRLLTYLQILATALALTSLAALWVTGPRASARRLMVLGQAVACGGILAAAAVLLTRWVTGGRFLTIPPSWPPSVSALVEDLQRNAVDQAVATGLTAALTALVGGALLTATGWAFLVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ00</accession>
    <name>A0A7K2ZQ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enterochelin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001611">
        <property type="protein sequence ID" value="MYW34397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="15549" checksum="4155B7795394FD75" modified="2021-04-07" version="1" fragment="single">MTAPGPGPAAEAAEAADAESPFAAFGLPGKPGTDAFWTAARTPLAVPADDGWLTLFLWRGSAAELDFESWSGPLPLRRWAATDCWYAEVPMPARLRVTYRFLVDGEGHPDPLNPAGAGGDRSIAATPDAPPQPHWPALGPDAILPLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ40</accession>
    <name>A0A7K2ZQ40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001611">
        <property type="protein sequence ID" value="MYW34398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="23893" checksum="AFA1208F68114B83" modified="2021-04-07" version="1">MDRPPHTARGDIGRRVAARRLQLDLSRQDVALRAGAAPGYIQYVEEQSATPGIGFLLRLADALETTVQELTGGTVDLPGGLGRAARGARMAELDETECRALLGDHGVGRVALNDGDGPVVLPVNYQVVDGEVMFSTGESSPLAGAAGTQIAFETDHIDDAFSKGWSVLLVGTVRVVEDEDEARRLRETAYSAPWAGEGREHVMVLVPRRITGRRIVVDDAPGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ85</accession>
    <name>A0A7K2ZQ85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001628">
        <property type="protein sequence ID" value="MYW34487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6292" checksum="C5BE508ECE15C622" modified="2021-04-07" version="1" fragment="single">MSTPQTPYAPEDGWRRLDPRTVLVTALVVAGVVAGAAVPAVLGLARWLGLPDAVLWALAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ96</accession>
    <name>A0A7K2ZQ96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ruvB</name>
        <name evidence="8" type="ORF">GT040_35965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001634">
        <property type="protein sequence ID" value="MYW34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="69"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="361" mass="38801" checksum="0DA8FCC9B76B81F0" modified="2021-04-07" version="1">MNWDETGPETDEPTGTVFDDRLVDADADGEDTAVEAALRPKDLEEFVGQEKVREQLDLVLKAARARGATADHVLLSGAPGLGKTTLSMIIAAEMNAPIRITSGPAIQHAGDLAAILSSLQEGEVLFLDEIHRMSRPAEEMLYMAMEDFRVDVIVGKGPGATAIPLELPPFTLVGATTRAGLLPPPLRDRFGFTGHMEFYAPVELERVIHRSARLLDVEIDVDGAAEIAGRSRGTPRIANRLLRRVRDYAQVKAEGIIDREIAAAALKVYEVDARGLDRLDRAVLGALLKLFGGGPVGLSTLAVAVGEERETVEEVAEPFLVREGLLARTPRGRVATPAAWAHLGLVPPQHGVRGQEGLFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQH5</accession>
    <name>A0A7K2ZQH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ComF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001651">
        <property type="protein sequence ID" value="MYW34610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="143" mass="14827" checksum="7523A8546D6A02B1" modified="2021-04-07" version="1" fragment="single">MRDWWREFSGLVLPVSCAGCGRPRTELCPVCGAALNGVPARRVRPSPRPVGLPAVHAVAPYENAVRAVLLAHKERGALGLAGPLGRALAASVRAGTEQTGAVGPLLLVPVPSARSATAARGHDPVLRIARAAADELRRTGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQI6</accession>
    <name>A0A7K2ZQI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_36250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001643">
        <property type="protein sequence ID" value="MYW34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="317"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="539" mass="60018" checksum="293AE5762928E329" modified="2021-04-07" version="1">MGHLEAGHLEYYLPDGRVLLGDASFRVADGAVVALVGANGAGKTTLLRLLAGELQPHGGTVSVSGGLGVMPQFVGSVRDERTVRDLLVSVSQPRIREAAQAVDAAEERILTVDDEAAQMAYAQALSDWAEARGYEAETVWDMCTMAALGVPYEKAQWREVRTLSGGEQKRLVLEALLRGPDEVLLLDEPDNYLDVPGKRWLEEKLKETRKTVLFVSHDRELLSRAAEKIVSVEPSAAGSDVWVHGGGFATYHDARKERFARFEELLRRWQEEHARLKALVLRMRQQAANSPDMANRYHAMQTRFKKFEEAGPPPEPPREQDIRMRLRGGRTGVRAVTCKGLELTGLMKPFDLEIYYGERVAVLGSNGSGKSHFLRLLAGEPVAHTGEWKLGARVVPGHFAQTHAHPELLGKTLVEILWSEHAKDRGGAMGVLRRYELERQGDQAFERLSGGQQARFQILLLELAGTTALLLDEPTDNLDLESAEALQDGLEVYDGTVMAVTHDRWFAKSFDRYLVFGSDGVVRETAEPVWDERRVERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQN8</accession>
    <name>A0A7K2ZQN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADH-quinone oxidoreductase</fullName>
            <ecNumber evidence="8">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_36645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="8">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001675">
        <property type="protein sequence ID" value="MYW34662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 7 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0874">Quinone</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="11">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="10">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW34662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="542" mass="57427" checksum="A12BC5918B1820A7" modified="2021-04-07" version="1" fragment="single">MTVTTSAPSGGGEAAIPPEDLVTLTIDGIEISVPKGTLVIRAAELLGIEIPRFCDHPLLDPAGACRQCIVEVEGQRKPMASCTITCTDGMVVKSQITSPVAEKAQKGVMELLLINHPLDCPVCDKGGECPLQNQAMSHGGADSRFDGKKRTFEKPVPISTQVLLDRERCVLCARCTRFSNQVAGDPMIELIERGALQQVGTGEGDPFESYFSGNTIQICPVGALTSAAYRFRSRPFDLVSTPSVCEQCSGGCGMRTDHRRGKVMRRLAANEPEVNEEWICDKGRFGFRYAQQRDRLTTPLVRNADGVLEPASWPEALEIAAAGLLAARGRAGVLTGGRLTVEDSYAYSKFARVALDTNDIDFRARVHSAEEADFLAARVAGRGRDLDGEGVTYTALEKAPAVLLVGFESEEEAPGVFLRLRKAHRKSGQKTFALASHATRGLVKAGGTLLPAAPGTETEWLDALAGGVGLEAEGAAAAEALRGEHSLIIVGERLAGVPGALSAAIRTAAATGARLVWIPRRAGDRGAIEAGALPTLLPGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQT8</accession>
    <name>A0A7K2ZQT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PrcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">prcA</name>
        <name evidence="5" type="ORF">GT040_37065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001682">
        <property type="protein sequence ID" value="MYW34740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_B">
        <property type="entry name" value="Proteasome_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="272" mass="29481" checksum="922AB4C06F11000A" modified="2021-04-07" version="1">MSTPFYVSPQQAMADRAEYARKGIARGRSLVVLQYADGIVFVGENPSRALHKFSEIYDRIGFAAAGKYNEYENLRIGGVRYADLRGYTYDRDDVTARGLANVYAQTLGTIFSSAAEKPYEVELVVAEVGSAPEGDQIYRLPHDGSIVDEHGSVAVGGNAEQISSFLDQRHRDGMTLAEALKLAVQALSREPGGGEREIPAERLEVAVLDRTRPQQRKFKRIVGRQLTRLLDAEAASATPTDAPSDTEETDTTDSTDTGTGTDPGTASGSTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR17</accession>
    <name>A0A7K2ZR17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">APHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_37395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001690">
        <property type="protein sequence ID" value="MYW34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd14490">
        <property type="entry name" value="CBM6-CBM35-CBM36_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033801">
        <property type="entry name" value="CBM6-CBM35-CBM36-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029767392" evidence="2">
        <location>
            <begin position="32"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="983" mass="103249" checksum="6DD5F9AF62BD5A4A" modified="2021-04-07" version="1">MRWKRLSERSITGLLIAGLVSVGLLPVQAAAAEATDLARGKTVTASGSHGGFPVVNANDGQVNTYWESNGHPSNLTVKLGADADLQSVVIKLNPDPIWGTRTQEFQVLGRTQSGTGFTSLKSRAGYVFNPATNQNTVTVPVSGRAADLQLQFFSNTGAPGAQVAEIQVLGTPAPNPDLTVSALSWSPSAPSETDNITVQGTVRNIGTAASAATTVDVSLGGVVVGSAPVGPLAAGASAQVSVPVGKRPQGSYTVSALVDPTDTVIESDNTNNSRTTASPLVVGQSPGPDLEVRSITSSPSNPAVGAAVTFTVAVHNRGTTAVSAGSITRLTVGSTTLNGTTPAVPAGATVNVPISGSWTATSGGATLTATADATNLVAETNETNNVLARSIVVGRGAAVPYTEYEAEDAVYQGTLLTSDAKRTFGHTNFATESSGRKSVRLNSTGEYVEFTSTNASNSIVVRNSIPDAAGGGGRQATISLYANGQFVRKLDLSSKHSWLYGNTDSPEGLTNTPGGDARRLFDESHALLAQTYPAGTKFRLQRDSGDNAAFYIIDLIDLEQVAPPTAQPSGCVSITQYGAVPNDGIDDTAAIQRAVTANQNGQISCVWIPAGQWRQEQKILTDDPLDRGQWNQVGIRDVTIRGAGMWHSQLYTLTPPHEAGGINHPHEGNFGFDIDENTKISDIAIFGSGTIRGGDGNHEGGVALNGRFGKNTKISNVWIEHANVGVWAGRDYDNIQSLWNPGDGVEFTGMRIRNTYADGINFANGTRNSTVYNSSFRNTGDDALAVWSSKYVKDQSVDIGHDNSFRNNTIQLPWRANGIAIYGGYGNKIENNIIADTMNYPAIMLATDHDPLPFSGQTLIANNALYRTGGAFWNEDQEFGAITLFPQNLPIPGVTIRDTDIIDSTYDGIQFKTGGGLMPDVKIQNVRIDKSNNGSGILAMGGARGNATLTNVTITNSRDGHVLIEPGSQFTISGSPTAARAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRI5</accession>
    <name>A0A7K2ZRI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001724">
        <property type="protein sequence ID" value="MYW34908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="20392" checksum="2CE6E9E896395DFA" modified="2021-04-07" version="1" fragment="single">MRLRALLETDALGLRLLGGDDELDRTVRGVMTTDLRDPSRYLSGGELVLTGLAWRRDASDSEPFVRILAGAGVAGLAAGEAELGDIPADLVEACVQHRLPLFAVNETVAFATITEHVVRQVSGERAGDLAAVVDRHRRLMTSGPAGGGPEVVLDLLTSDLDLRAWVLSPTGRQIAGAGAPLPTPLGAALAGHHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRN6</accession>
    <name>A0A7K2ZRN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_38590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001755">
        <property type="protein sequence ID" value="MYW35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="26555" checksum="915438F4339B0341" modified="2021-04-07" version="1">MAGLTVRHRRNIALDAVDLDFAPGVHGLLGPNGAGKTSLIRVLATVSPPDAGQVELLGSEVGRGADHRERASVRRRLGYLPQEFGYYPGFTVREFVGYVAWLKEMDGAQVAAAVERAVDRVGLGERIDAKVKTLSGGMVRRVGIAQAIVNDPALLLLDEPTAGLDPEQRVEFRALLREVGLTSTVIVSTHLVEDVAAACSDVTLIEAGRIAYRGTTADLIELGDAADGLGGNPIERGYTAALRAHRTAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS87</accession>
    <name>A0A7K2ZS87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001796">
        <property type="protein sequence ID" value="MYW35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="11746" checksum="95DF24ABB4056A3D" modified="2021-04-07" version="1">IEARALVEARLPDPSLRHTASPLLRGLYEGGAAVTDTGLLSVDPGDSRIVDREGRPHPRRFALGPFTTARNSGAFTRPRTGGPAFRQNDAAARAALSFLRDLSCHGRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSI2</accession>
    <name>A0A7K2ZSI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_40055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001832">
        <property type="protein sequence ID" value="MYW35303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="114"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="339" mass="37342" checksum="F5547CCF13741DEF" modified="2021-04-07" version="1">MAVHTSQSVVKAAGDDVARGRSRGTGTPPPAPGRIRRGLSTHWYAWTMVAPVVLVISVIIGYPLLRGIYLSMTDANERNVARTIGVNELPATYKFVGADNYIDALTGSQFLGTLGWTLVWTVSCVSITFVLGMALANILNRRIAGRSAYRMALILPWAIPGFVSVFAWRFLYNEERGLLNTVLGGVGIDGIPWLNDPTWAKFAVIAVNVWLGVPFMMVALLGGLQSIPSEQYEAAEMDGATAWQRFRHITLPGLRPVSTTVILLSTIWTFNMFPVIFLLTRGGPGEATQILVTQAYKFSFEISPRDFAQSSTWGVLILVLLMLFAVVYRRVLRSQGDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSS3</accession>
    <name>A0A7K2ZSS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA helicase RecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001841">
        <property type="protein sequence ID" value="MYW35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="12899" checksum="B6DEF16334F23A3D" modified="2021-04-07" version="1" fragment="single">MTALPGETPGTVGTDTPQGAEPPAATDVEGPAHAEAPEAEAEAEAEVAGETGDAAGDGPAGEAPAAAALSEAQAELAAQRELREKIAKRKAEKEGPVAAGTKLSGPAADLLAAVRAVESGEKAGTEFFDSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZT27</accession>
    <name>A0A7K2ZT27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001864">
        <property type="protein sequence ID" value="MYW35458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="18297" checksum="5020EEFB9C73E787" modified="2021-04-07" version="1" fragment="single">RSSDLETDLADARGLLEGTTQATSTADLRGRIARAEAVLTDVREATAAGPYDPVDALRRVEEADVALDEALAGAREQEAGGRRARSLLDQAMLTARSAIAAATDYITTHRGAVGAQARTRLAEAHRRWEQARQLADGDAQGALAQAQQADALARQAQGLAEQDVRGFQGPGGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z694</accession>
    <name>A0A7K2Z694_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional metallophosphatase/5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000033">
        <property type="protein sequence ID" value="MYW27856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5_nucleotid_C" evidence="1">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="13277" checksum="B45A00D283403FB6" modified="2021-04-07" version="1">RTAAGGPVDTAKLTNADGIPDYNYDAVSGVTYDIDIAQPVGSRIVGLSFEGKPVDPAARFVFAVNNYRASGGGNFPHVPGAKQVWANSDEIRNTIIAWVQAKGSVDPAAFASVGWRLTREGTPVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6B7</accession>
    <name>A0A7K2Z6B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000043">
        <property type="protein sequence ID" value="MYW27876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076965855.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000043.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="139" mass="15333" checksum="080568EE92F228C8" modified="2021-04-07" version="1">MSDLLERLRGRGWRMTAQRRVVAEVLDGDHVHLTADEVHARAVDKLPEISRATVYNTLGEMVSLGEVLEVSTDRRAKRYDPNAHRPHHHLICGRCGAIRDVHPAGNPLADLPAEERYGFTVSGVEVTYRGLCPSCAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Y0</accession>
    <name>A0A7K2Z6Y0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_02160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000100">
        <property type="protein sequence ID" value="MYW28106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="27217" checksum="252B8826AAB2E60F" modified="2021-04-07" version="1">MPPADAPAEPDAAPEEPGSGPGDRETPAAPAGTEDTLDLKLTEELLAFIAEDRDKAARRRDPAGELLGDPATWPGATTEAGVFHLVPVVLERDLAVLSRWMNDPAVAAFWELAGPASVTADHLRPQLEGDGRSLPCLGVLDGTPMSYWEIYRADLDPLARHYPARLHDTGIHLLIGGVGNRGRGVGTTLLRAVADLVLDNLPRCGRVVAEPDLRNTPSVSAFLSAGFRFSAEVDLPDKRAALMIRDRTYRDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z775</accession>
    <name>A0A7K2Z775_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000108">
        <property type="protein sequence ID" value="MYW28163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="15648" checksum="0C1EB24018B12738" modified="2021-04-07" version="1">MRDSGDRPGQPPDSPEGAADPATHALLASAVDDWAAAIGANDAERIAAFMADEWVIVSGSGITDRDAFLALVTSGDLTHSAMQAITPPRIRVHGDTAVVTARITNTAHYGGDRFDADEWTTDVFVRQDRHWRCVLSHITPAASPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z791</accession>
    <name>A0A7K2Z791_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000116">
        <property type="protein sequence ID" value="MYW28219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="23341" checksum="B6057FDE74C2ADFE" modified="2021-04-07" version="1">MARQLLGTSETAECGCDPAPHREDDGTYSHWAGCPIADEQQAADAGLEPDAGLRDRIAAAIRAESSRVDDLALADAVMPVVTDRLRRNWGQMRDRVAELETEAQRLVDAAPPAPADRAAVLREGAASVESSDVTYDTEAATAALTNGGPFALIAYVQLAIGAHLRRLADEAAAGVQPPTTWSPDDPLTAQWAEATGKPTPLCPCGYVPVACDVDRGCTPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7D2</accession>
    <name>A0A7K2Z7D2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000139">
        <property type="protein sequence ID" value="MYW28266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="89" mass="9832" checksum="D38F02944EBD2F37" modified="2021-04-07" version="1" fragment="single">EAAEALDAAQEEATRRRREAEEILGAARTEAGQERERAREQSEELLASARKRVEEAQAEAQRLVEEADTRAAELVAAAEQTAQQVRDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7D5</accession>
    <name>A0A7K2Z7D5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000129">
        <property type="protein sequence ID" value="MYW28254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="9610" checksum="61721ADEF45625B6" modified="2021-04-07" version="1">VNTPYGTGGRLDGYEIRTAAVARSVPCLTTVQALAAAVQGIDALNGGDVGVRSLQEHAEQLTAMTVRDQLELAGIEVSSATETASRARAVPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7G8</accession>
    <name>A0A7K2Z7G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Terminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="574" mass="64330" checksum="B6FE0FD6F93CE57F" modified="2021-04-07" version="1">MPHVTVRAPSHDRSRSIGWLAVAWMEYFVVHGPGDVQGMPVSHGDEYTGFVVDCYALGEGGKDDGRLLYDSAFFSRPKGCDKSGLGARIGLFEALGPCRFYGWAEGGEVYRDPWGLGFEYVYETGEPMGRPVTVPYLRIMATEEGQTGNVYDTIYFNLTDEASLLSHVPNVDPGLTKINLPDGGEITPSTASSSSKDGGKETWVCFDETHLYNTPELRRMYATVTRNLRKRKKIAQTWYLETTTMFAPGQDSVAERTYEEAEAIREARKKRGRARLLYDHRYGIVKDLKNEDELRAALRDAYGDAMEWIDEDTLVDDFYDLRNDSADGKRYFLNSRTSSSDAWMDPDAWKLCRREEEIAPGELITLGFDGSIRDDATALCAARVSDGHLQLLGVWEKPEGPEGDGWQVDREAVNAAVASAFDRYEVCGFYCDPPHWQDYVDAWTRDYGDNLQVRAVQSRPLEWWTNRPTAMEQALNRFTEAVDDKGLSWAGVDEADDVDTPFARKGLALSRHVLNAKRRPMGGNRHIGIGKEHPKSPKKIDAAMSATLAYEARADAVAAGITKRKKRSGRLVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7J4</accession>
    <name>A0A7K2Z7J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="8409" checksum="76034E8803908C48" modified="2021-04-07" version="1">MSARNTLLDLFLHGGDGSQPEFEQALDDYAHELAEKIRTQKLRAPEGFVHRQTWVDAWSEGRDDMADLIDPEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z821</accession>
    <name>A0A7K2Z821_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000194">
        <property type="protein sequence ID" value="MYW28499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="293" mass="32097" checksum="FE08713D1ABB9703" modified="2021-04-07" version="1">MTIHRAVVARVQPLTATMTRVTLHGEGLAGFESTGVGDEYIRLFFPHGPDRSDVSLPVITEKGWETPEGRPVAPMRTYTVRAVRPESREVDIDFVLHDHGVASTWVAGAQPGDVLGVNDPTGLYSPPDDLAWQVLIADQTGLPAVARLLENTPDEVATRVVVELPGPEAVQPLPGTKVTWTYGGNGHEASRLAELVSAAIPPGTDMTGGYVWIAGETNALRTVRRYLRKELGLPATRFKVVGYWIPDADSWNERYEALPDAVRAELLALWDDPVDDEEDLTIRYETRLSDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z893</accession>
    <name>A0A7K2Z893_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECF transporter S component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000203">
        <property type="protein sequence ID" value="MYW28566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017196">
        <property type="entry name" value="ECF_substrate-spec_UCP037395"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037395">
        <property type="entry name" value="UCP037395_ABCper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="283" mass="29567" checksum="E88D42BF661BF870" modified="2021-04-07" version="1">MTELPPLTDRSAGAIRIGPRAGIVIALAAFLGLVAFFWPFLVAPGRLGANYAPPLIFGVLLVLVLCVVISEIAEGGINSKALAMLGVLSAVNAALRPLGAGTAGIETVFFVLVLAGRVYGPGFGFTLGCTSLFASALITGGVGPWMPYQMFGCAFVGMLAGLLPRATGRREVMMLAVYGSLSGYLFGFLLNLSFWPFSVDPNSSIAYLPGLPFTEQWQRYLAFDVATSLGWDTGRAVTNFVCITLAGPAVLTTFRRAARKARFRAPVRFAGAAEEGTGGGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z895</accession>
    <name>A0A7K2Z895_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000204">
        <property type="protein sequence ID" value="MYW28574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="9074" checksum="4B9BDCB97D7F869B" modified="2021-04-07" version="1">MAEEARVDRGVHGEQAEEEPQAPEVNRTPWPIGTRHTATPLEADWALATTTYNRIAADLTGRDGEGQTIRIVLDEGLPHTDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8A8</accession>
    <name>A0A7K2Z8A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_04430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000198">
        <property type="protein sequence ID" value="MYW28535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="23964" checksum="7B91DCC7D6E31CB8" modified="2021-04-07" version="1" fragment="single">MATTTVAPPSGAGTSRTGAARTAFLLLAAVAALALALCASVMFGSRSTSFGDVLGVLGGTADDNVTAIIESRYPRTALGVLAGLCLAVAGTLMQGVSRNPLAEPGLLGINAGASASIVAATAWFGASGATDTMWWALPGALVAGVLVHVIGSAGTGTSVVRLVLAGAVLTAVLMAFIQAVTLSKPQVFDSYRYWVVGALGGRDFDVFWSVLPFAAVGFLLALALGPGLNALALGDATAVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8B5</accession>
    <name>A0A7K2Z8B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF881 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_04550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000201">
        <property type="protein sequence ID" value="MYW28558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="30030" checksum="502A16A900ED56D5" modified="2021-04-07" version="1">MNNDENPRSQEPEHPEWPEQPGAGVSGAPDAPVQPPAAEEVSGRQRLLAGLWPPRVSRAQLIVAVLLFGLGLGLAIQVRSTSDDSALRGARQEDLVRILDEVDDRTQRLEDEKQRLDAQRTELENSSDQAEEARKQTLEKERQLGILAGTVAAQGPGITLTISDPSGAVAADKLLDTVQELRAAGAEAIEVNGVRVVANTYFSGEGGDIQVDGKKIEAPYEFKVIGKPQDLEPALNIPGGVVQTLEKEQATAVVERSEEIVVDALRPAERPDYARSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8D1</accession>
    <name>A0A7K2Z8D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000207">
        <property type="protein sequence ID" value="MYW28591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029577078" evidence="2">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="19127" checksum="C9455D01FD89DF05" modified="2021-04-07" version="1">RNLAATGAGALLIAVLGTVVTLGLTAGDPEEPGGSRNVTTEQSSPESTPDDASPADEPDGGPAPDDGAPGEEVPVTPGTSGSATPSTSGSPSPAPSSPDGSSPGTGEPSSTLPTEDPTSDGPSPSGKPTTPTKPPTTPPTTPPTTPPTEPPTTPPTETPTEEPPPPPDTTSSAGGPSESATATATTEAPAESEDPTEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8K5</accession>
    <name>A0A7K2Z8K5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_05070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000224">
        <property type="protein sequence ID" value="MYW28653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="34846" checksum="69A5E0ED4D5DA8E6" modified="2021-04-07" version="1" fragment="single">MDRSQGTAAGLVLAGRYRLGEVLGRGGMGKVWRAHDEVLHRTVAVKELTAGLYVAEADRLVLHARTQKEARAAARITHPGVVTVHDVIEYDKRPWIVMQYVDGPSLADETKEKGDIAPREAARIGLHVLSALRAAHSAGVLHRDVKPGNVLLARDGQVLLTDFGIAAIEGDSTITRTGELVGSIDYLAPERVRGGDPGPASDLWSLGATLYTAVEGRSPFRRTSPISTMQAVVTEEPPPPVNAGPLGPVITALLRKDPADRPTAAETEQMLLDAMEGREPRSAQAHVPTQRVPEEDRFAYAGTDGATARLPGTVPSTPAPAAPVAGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8W1</accession>
    <name>A0A7K2Z8W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ACR3 family arsenite efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsB</name>
        <name evidence="5" type="ORF">GT040_05605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="374" mass="39517" checksum="1419B75662002440" modified="2021-04-07" version="1">MSAEAVTAAGPAGPAAGRLSFLDRFLAVWILIAMAAGLGLGRLVPGLGGALAKVTVTGVSLPIALGLLVMMYPVLAKVRYDRLDSVTRDRRLLIPSLVLNWIIGPALMFALAWVFLPDLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSVFQVVAFAALGWFYLTVLPGRLGLEQTALDVSVWEIARSVLIFLGIPLLAGFLTRRLGERAKGRTWYETRLVPRIGPFALYGLLFTVVVLFALQGDAITAKPLDVVRIALPLLVYFALMWAGSMAVGRAVGLEYPKATTLAFTATGNNFELAIAVAIATFGVTSGQALAGVVGPLIEVPVLIGLVHVALAARRFFPPTSPAAARAVAPEGSAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z904</accession>
    <name>A0A7K2Z904_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000259">
        <property type="protein sequence ID" value="MYW28829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="13907" checksum="991D896FC35E13F7" modified="2021-04-07" version="1">MTTTPHPEASTETTAVGESRLHIALRGDLDHENADAFVRDVAARLSARPEATDLRLSCAGLDHIDSMGLSALLMIRRHARTTRVRLHLDERPAHLERLLRLTGTLDYLTGPDGTERGAGSPPAPADGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z975</accession>
    <name>A0A7K2Z975_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000287">
        <property type="protein sequence ID" value="MYW28886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="16"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="19982" checksum="01723FB5272DCFBE" modified="2021-04-07" version="1" fragment="single">MATIDRQTATLALAHALSTAGRGLPVFPLSATKLPALRSPHHGEQPPVHCRGECGLPGHGVHDATTDPAAVRALFAAAPRATGYGIACGRAPHRLIGIDLDIDTAHGNDSVGALQQLALQHLFTIPPTVTVLTPSGGRHLWLTGPADTTVPNSAGRLAPGIDVRGTGGYLVGPGSVTANGRYRLAPGTAHLPPAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9F9</accession>
    <name>A0A7K2Z9F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000306">
        <property type="protein sequence ID" value="MYW29000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="31361" checksum="5AA841553FDF52BB" modified="2021-04-07" version="1" fragment="single">MIDARRLRILRAVADHRTVTAAAAALYLTPSAVSQQLAALEQETGHRLVERGARGARLTAAGEILLSHANVVLAQLERAEAELADYGAGVAGTVTVAAFATGIGLVLAPALTELARTAPGIRVKVQDAEGDASVPMVLDRQVDVAVAVEYRGAPAEDDRRLTRVPLYSEPFDAVLPVDHRLADQDQVAVADLAKDPWISPYPGNPCHDVVVLACEYAGFAPRFDHSSDDFRAVVALAGADAGVALVPRSALRGMELTGVVVRPVEGSAPTRRVFAAVRQGAEGHPLIRPVLDAMEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9G7</accession>
    <name>A0A7K2Z9G7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_06900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000309">
        <property type="protein sequence ID" value="MYW29010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW29010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="27463" checksum="EC2EEDDDB54F20BD" modified="2021-04-07" version="1">MTTRTAPPAPTGRALTPSRTAATATRVLRQLHHDPRTIALLLIVPVAMITLLRYVFDGAPGTFDSIGASLLGIFPLITMFLVTSIATLRERTSGTLERLLALPLGKGDLIAGYALAFGAIAVVQSALATAVSVWLLGLDVMGSPWLLLLVALLDALLGTALGLFVSAFAASEYQAVQFMPAVIFPQLLLCGLFIPRDQMHPVLEAISNVLPMSYAVDGMNQVLHHSDLTGDFLRDIAVVAGSALLVLCLGAVTLRRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9I1</accession>
    <name>A0A7K2Z9I1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_06605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000300">
        <property type="protein sequence ID" value="MYW28952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029823987" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="61"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="217" mass="22712" checksum="94BDBBD8485A6930" modified="2021-04-07" version="1">MAAAFSSTAATSSVAAASAPRPLGQLVPVPAQVVPGGSPYAITSTTPVRVAGGSTEVGGGPGGYYTKAQYREIVRYAASRYPEVVPEVDLPGHTNAALASYAELNCDGVAPPLYTGTMVGFCSLCVPKPVTYDFVDDVLREVAALTPGKYLHIGGDEAHATSHEDYVAFMAKAQAVVWSPAAARDWETYRVCLAAQGPRLTELGIGFYRSPQVDWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9M0</accession>
    <name>A0A7K2Z9M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000325">
        <property type="protein sequence ID" value="MYW29071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041674">
        <property type="entry name" value="TetR_C_22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17928">
        <property type="entry name" value="TetR_C_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="22379" checksum="A439B6DBAFE85D3E" modified="2021-04-07" version="1">MGPVPHPNPNLRRAPVQQRSADRLARILDACAGLLDETGYEQLSTRDVALRAEVPIGSVYRFFSNKRALVDALALRNLDLYAERITARLGPLPADDWRGAIDAVLDEYLAMKRTVPGFALVDFGPPSPAEDASDDANRRLAGRLTDLLAGHLGRHPGPELLRAILVSVEAADALLQLAFRTDPSGDPAIVAETRTLVRAYLAQILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA05</accession>
    <name>A0A7K2ZA05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_07785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000359">
        <property type="protein sequence ID" value="MYW29180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510320.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000359.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="62"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="252" mass="27901" checksum="22703F8F8AB823CB" modified="2021-04-07" version="1">MSQTVDRALSILPLLAQGPADLGQVAERLGVHKSTALRLLRTLHEHGLVYRQQDQRYRLGARLFALAQEAVENLDVREIAHPHLVELNDRCGHTVHLAVYEEQEVLYIDKVESRYPVRMYSRIGKPVAITVAAVAKLLLADLTEPERRAIAEKLDYPMYTSRSTPNAAAFLKELAVVREQGWATDLGGHEESINCIGAPIRGADGRVVAAMSVSAPNVVVTAEELLTLLPLVRRTAETISREYSGTNRPKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAT4</accession>
    <name>A0A7K2ZAT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000406">
        <property type="protein sequence ID" value="MYW29385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008715">
        <property type="entry name" value="SAM-MeTfrase_NodS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05401">
        <property type="entry name" value="NodS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="23357" checksum="543F8CCD9D9021E4" modified="2021-04-07" version="1">MSRPGTPATYFDAMYGSAEDPWSLTERWYERRKYDLTVAALPLPRYRRAFEPGCSVGELTRRLAERCDTVLACDRVESAVGTARRRTAALPNVSVHRMLLPEEWPEGSFDLIVLSELLYYLDEMTLDTVLERTVSSLEPEGTLVTVHWNHPVEEHLTTGAGIARRVADRPGLVLLADHREEDFVLQVHRRTTANGGRPAGVAAREGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB37</accession>
    <name>A0A7K2ZB37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ftsW</name>
        <name evidence="11" type="ORF">GT040_09705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000450">
        <property type="protein sequence ID" value="MYW29543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW29543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="442" mass="47366" checksum="5C1CD0B86750D1FB" modified="2021-04-07" version="1">MPAEKSSAVRSRRPAPPRSAGYGSPGPRAPRGGVRRLYEQARRAWDRPLTAYYVILGSSLLITVLGLVMVYSASMIQALNIDKSSTYFFGKQFVAAVIGGALMLIASRMPVKLHRGLAYPMLMVTVFLMVLVQVPGIGMSVNGNQNWIYLGGPFQLQPSEFGKLALILWGADLLARKQDKRLLTQWKHMLVPLVPVAFMLLGLIMLGGDMGTAIILTAILFGLLWLAGAPTRLFAGVLGFAAALAFLLIWTSPNRMSRLSCMGIIGEPDPDDGCWQAAHGIYALASGGWFGSGLGASVEKWGQLPEPHTDFIFAITGEELGLAGTLSVLALFAALGYAGIRVAGRTEDPFVRYAAGGVTTWIMAQAVINIGAVLGLLPIAGVPLPLFSYGGSALLPTMFAVGLMIAFARNDPAAKAALAVRRPGVRWKTMRRRVTKRPSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB82</accession>
    <name>A0A7K2ZB82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000464">
        <property type="protein sequence ID" value="MYW29627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="11552" checksum="3A1EEB0A5FC3A205" modified="2021-04-07" version="1">AADMRAEGYTVAMTRTRGRELEDAAGDLRALLENPPGLAGLPVTVVSAGRVSPGMPKAVRERATVSHAYRARQSPHGRHVVLREADHMVLTTSAAELAEEVRRSVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB90</accession>
    <name>A0A7K2ZB90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF839 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000457">
        <property type="protein sequence ID" value="MYW29582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029796290" evidence="2">
        <location>
            <begin position="31"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="388" mass="40282" checksum="E937979B29C2030E" modified="2021-04-07" version="1">MERRTFLRTAVVGTSAAAFGGTLWRGAASAAPAQPAPGPYGALQAANGNGIQLPSGFTSRIIARSGQTVSGTSYRWHSAPDGGATYADGSGWIYVSNAEVSSGSGGGASAVRFDSSGTVTSAYRILSGTNNNCAGGSTPWNTWLSCEEVTRGYAYETDPWGVNASVRRPALGRFKHEAAASDPDHGYIYLTEDETDGRFYRFRPTTWGNLSSGTLQVLVAGTGTSGPVTWADVPDPAASSTQTRHQVSGAKVFNGGEGCFYAAGTCWFTTKGDNRVWAYDANTSSISLAYDDSLVTGGAAPLTGVDNVTRAGSGDLYVAEDGGNMEICLITPNDTVAPFLRITGQSGSEITGPAFSPNGKRLYFSSQRGTSGSSSGGITYEVTGPFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBH0</accession>
    <name>A0A7K2ZBH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000483">
        <property type="protein sequence ID" value="MYW29679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="39"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="473"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="563" mass="60002" checksum="CD9F6CA85D9AFACE" modified="2021-04-07" version="1">MRLDELLEELQARINAARGTRDRVHSLLEAVVSVGRELDLSQVLRRIVEAGAHLVDAEYGALGVIGPDGRSLSQFLTSGMTAEQRRRIGPLPAGHGLLGELIRHPEPLRLSQLGTHEASFGFPEHHPPMRTFLGVPIRVRDEVFGNLYLTDKRDGLDFDAEDESVITTLAVAAGVAIDNARLYESAQRRHRWLRAGAEVTNHLLSGDARQDVLELIARRAGEITGARLAEVSSPVPGTGDLIVELSVALSEAEYEGEGDDGLQGRVVPVDGTLAGAASAVGAQVVSVCLGEDPRFLADRHLAAGPGPAVAVPLGAAGADVLLLVRAVGEPVFTEADLEPLLAFAGQAALALELAVRRRDAEHVALLEDRDRIARDLHDLAIQRLFATGMTLQSTARLIEHTGAAERVARAVDDLDETIKIIRSTIFGLRARDDGPASSLRARASRTVGDAVTSLGFPPRLSMEGLLDTDVPLDVAEHVVAALGELLSNAARHAHASRVEVSLKATADEVRLTVSDNGRGIPEQSRRSGLDNLAERARQAGGALELSTPDGGGSRLVWRAPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBH1</accession>
    <name>A0A7K2ZBH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TOBE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_10080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000462">
        <property type="protein sequence ID" value="MYW29615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="83"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="15855" checksum="44967C1F7ED6F6B6" modified="2021-04-07" version="1">RVLVLDDGRVLQDEPPAEVTRHPRSPWVARMLGRNAWPGTATADGLDLAGGGHLVVAEPLTPGTEALAVIAPEAVSVHREKPTGSPRNIWPGTVREITSGGSRLRLLITSDRAPDLVAEITPQAAAELRIADGTEVWTGVKATEVTVVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBL5</accession>
    <name>A0A7K2ZBL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000491">
        <property type="protein sequence ID" value="MYW29746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029606920" evidence="1">
        <location>
            <begin position="34"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="433" mass="46613" checksum="59B9A87C8ADA9106" modified="2021-04-07" version="1">MKQRARFSRTAVVGGAALALVLSLSGCGGGSDAADGDTIHVLVYGDAANKVEKELVATFNKTSKVKAVLDTIPGADYQAKLQTIINSKQAPDVFFNWGGGSIKPFVDAGLLLPLDPFIDKDPDLKAKFLPSVFNSAAVDGTSYGIPMRGTQPVLLFNNGKVLKKAGVEPPQTWDDLLAAVKALKADGVTPIALGGGDRWPTLMWFEYLYDRIAGPELFQKALDGDKDAWASPESRQALGKIRELVDAGAFGTNYDSVKFTDQGSPTLLATGRAGFELMGSWEYSTQQDAHPEFAESDLGYSAFPSVEGGKGDRANLVGNTNNFYSVLKKTKHPEAVAEFLKLMYSDQFVKAQLSIGNLPTTTNTEGLLDTAASPEFAKFQYDMVKEAPAFQLSWDQAYPQSAATAMHQALQQFFNGSMDEDAFIKAMQALPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBS2</accession>
    <name>A0A7K2ZBS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000503">
        <property type="protein sequence ID" value="MYW29820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="249" mass="27000" checksum="06707A7F8FC683F8" modified="2021-04-07" version="1">MNTPGTAAATRAEYCVIACAEAWRGDGEVLASPMGAVPSVGARLARLTFAPELLLTDGEATIVGPDGEAEGWLPYRKHLTLVTGGRRHVMMGASQIDRFGNQNISCIGDWEQPARQLLGVRGAPVNTLNNPVSYWIPRHSPRVFVERVDMVCGVGYDRAEAAGPSATRFHRIPRVVSDLGVFDFATPDRSMRLASLHPGVTVEMVREATGFRLTVPADVPYTRDPTPAELALIREVIDPSGTRNREVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBU4</accession>
    <name>A0A7K2ZBU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000496">
        <property type="protein sequence ID" value="MYW29782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="755" mass="81285" checksum="A4FC4A5A79BC1DC2" modified="2021-04-07" version="1">MPTYHEIMTTDLSAITTAADKWTGMAGEFNKQEKAYEKEVQGITLERTWIGQSAEAANAQFRVMLNEYRAAQTQAKAIASLLRDAHTQFTEFKSKLQTVKADALKADMLISDAGRVTFDMSSLSESSRAVYRHDPDYQKSVRDAVGSWQRAIDRLVAQTSDADAGVQIALKAVVKDTDATDGTRDGFNGQALGDIEAYELRNTQEIAERLLDGEKVSDADLAEMGRAMRDQAGDKVFAQGLLNKLGPEGIVKLSDVMSDRERDGGSSADQYTKLLGGLANTVATATQVPGSMTDAGPGSAKYQAWLNSPDGAFYKKFTEGLKEAGAKNYDSKTNPLYGYRPFVEMMTRADQPFDDQFLNQLGHDMIAAEKDNRAIFEQWGGNHREGRADALDSLLGVMSKNPDAATAFFDPKLEHGKAHLDYLVGNGDDAREWPKLNTVAGPRVFIEDDPLSRHGLGLALEAGATGEEPGSPLGKPGPHSEGQARVMQGIIATLDQGTNGDTVPEALKVPLGRVLNDYTADTHAILGGYAPGSPSGLDDVDGSGDSASITNSKASLLRVMRGVSDGVAGEDADGNPIRVFDTLYESQRLHSVDYLDAADHVNQSRLSENVTSWDVRSRDVGEVFGGMNAIGTDMILDVRDAEIGKINDQARYGYHGLGAVVNMIPQVGDIAQRAVDAAAYEWSTSVMAEAEKDALSNVSVVTAEGIASTNGLIRDWAATRDAPDDSPAVRNAMQEAKQSYAGGREEGYSALRTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC21</accession>
    <name>A0A7K2ZC21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000524">
        <property type="protein sequence ID" value="MYW29889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="269" mass="28845" checksum="8F95C2F0271A6C30" modified="2021-04-07" version="1">MSENSESASVPGPYGTILVERRGRTALLTLNRPTALNALSLDVMRETVEATEALDRDPEVGCIVITGSGSRAFAAGADIKEMQPQSYMDMYLSDWFAAWDRLGQLRTPTIAAVRGYALGGGCELAMLCDLVIASETAVFGQPEIRLGVIPGIGGSQRLTHAVGKAKAMDLCLTGRNMDAEEAERAGLVSRIVPDADLLTEALAVADTVSGMSAPVAMMAKEAVNRAFETTLAEGVRFERRLFHAVFATADQKEGMKAFTEKRAAEFTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCV3</accession>
    <name>A0A7K2ZCV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000596">
        <property type="protein sequence ID" value="MYW30095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="33055" checksum="9CE0EEC948F3FB68" modified="2021-04-07" version="1">MTETRVHEVKVAAEAEEVYRLLADLANWPWIFRSFVHAEVIGQADGFERCGMWTTSDERVEQWVALRRTDAAALRIDFRPEEPAPPLTLMERSWVVVPLSPRESLVRLEHRYEVEGNDAESLLATAGVIDAIADAETEALRTAAELEPERRVVVNDQVTIGGDTASVHAVLHDVTAWPELLPHVVRADALQDEKGLQLVEIDTREADGSLLRMRTARVALPEHLIAYKQLVLPPIGSSHTVRWHLEPTRGGVAVTSEQTVVLSPAAVDVAAVTAFVRRELSAKVRLILDRAKEVVEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD74</accession>
    <name>A0A7K2ZD74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000652">
        <property type="protein sequence ID" value="MYW30307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="21399" checksum="F648CB3B80A1D31F" modified="2021-04-07" version="1">MNKIVSSISVSLDGFFEGADRDIEWHSVDEEVHQHFNDYLRTAGAFVEGRVTYQLMEEFWPTADQDPANAGPMAEFAGIWRDMPKYVYSRTLESVGPGATLLREVDRDEVCAVRDAAAGDLIVGGADLVETFRRLDLVDEYRVYIHPVLLGRGRPFFGEAADLQGLRLLEGRTFGNGVVLLRYETDPAPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDG5</accession>
    <name>A0A7K2ZDG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000659">
        <property type="protein sequence ID" value="MYW30372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="247" mass="26372" checksum="856AFC8281A4E89C" modified="2021-04-07" version="1">ALLKVWPALVLIGVRRGRPTRAAWSAAALTAAGLGVGFALWMPGAYAFLAFQRDRGLEIESLGALYFHLARHTGWEGRVELHYGSMEFLGPHVGLVSTLVLGLAVVALGWLLVWRLRARTFAAHTPAQAAFTAVLLFTTTSRVISPQYVVWLVGLAAVCLAFRGGGMVRPAVLVLAAAGATVLEFPVYFAEVVASDAWGVALLLVRNGLLVAASLIAARQLWRETVPGGRSEKAVPARGDQPSRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDU2</accession>
    <name>A0A7K2ZDU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000713">
        <property type="protein sequence ID" value="MYW30527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029447626" evidence="1">
        <location>
            <begin position="39"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="211"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="415" mass="43714" checksum="EC0B171DF230377B" modified="2021-04-07" version="1">MPRRQGYTLLIALLAGTAVLAAATVFGTSLLSATRAPAPRPPAETHAAAPNPVAPAHIGGNWVATWTTAPVGPEPGTAGGLPGSTIRNVVHTSVGGDAARITLSNLFGTTPLLVDRATVNTRPVTFDGAASVTIAPGGQTVSDPVVVPVSADSDLEVAFRTPRPGGPVTFHPNSHQTSFLADRRATWSTAKWRYLTAVDVRNEDVPGTVVVIGDSLTAGSGSTTDANNRWPDVLSDRLNGRYAVANAGIAGNRLLTQGFAGQPGMVRFERDVLSVAGVRTVIVALGINDILQKPHESDAGRIVAGLRSLADQARARDLPVVGATLTPFRGYHTWTPEREAVRLAVNEQIRSGTVFDTYVDFDEVVRDPSAPNRLRAAYDSGDHVHFNDAGYRALGERVDLASLEPVRTAPDSDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDZ8</accession>
    <name>A0A7K2ZDZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000717">
        <property type="protein sequence ID" value="MYW30580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="443" mass="46897" checksum="F01E1ECB90BF110B" modified="2021-04-07" version="1">GALEEAMRDFQAERVRLASGPPGERPPVEVLRRQSQVLALAESARMAEITTDIAVHGHPTEPAVPRRLFWYAELSKPRLWARRVTGNVTFRSVLFQNALRTALGLAAARAVAGSLDLSHGFWVLLAVLTLGRTTAGATWRAVRLAVAGNAAGALVAGALLIGLGPHTDAYAALLAPVMLVAFALGPLLGIAYAQGLFTLVVATAFAQIEPVTWRLSEARMIDVVTGSVIGLLCGLLAWPAGARREVHRAMAELLRVCAELVPVTAQALLTPAGGSRAGPQALPDSSRAAGPRTLPGVHRLRLAEAAYTQYRTEAPGEDTRTDWHAMLIVANHMLLGAHWLPRFGLRPEAGASAPAAAWARTTAEDLVAETDRIASELTGGAPRPVPRWTAPDGPPPTPLSVDLEVWMTSLAHQLTRIDSSLAPPQGPVVAPVTPSRRRTAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE90</accession>
    <name>A0A7K2ZE90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_15635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000730">
        <property type="protein sequence ID" value="MYW30671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="32305" checksum="B3A294E4DD226457" modified="2021-04-07" version="1">MTALAAPPTAPETGHPPQDPPGKRVRKGGAGRTMKGGWLSYVILGFALLISAFPFYWTIVAASRSNADMAKVPPSLLPGPNLIKNFEQVLEEADIGKALLNSLIVSSSITLGTVLCCTLAGFAFAKLKFRGRGALLTLTIGTMMIPPQLGVIPLFMLIAELQWVNQLQAVILPGLVSAFGVFFMRQYLVQSLPDELIEAARVDGASTARIFWSIVIPIARPGMAVLGMLTFMTAWNDFFWPIIALSSQEPTVQVALRQLGGGYVNDQSVIMAGTLLGTLPVLLVFGLLGRQIVGGIMQGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEW1</accession>
    <name>A0A7K2ZEW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pantoate--beta-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000779">
        <property type="protein sequence ID" value="MYW30891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="63" mass="6822" checksum="89C58D451617EFCC" modified="2021-04-07" version="1">ILEDAAARDRRPLVLDYLALVDPADFTEIPDDRESGDAILAVAARVGETRLIDNIPLTFGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEZ6</accession>
    <name>A0A7K2ZEZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sec-independent protein translocase protein TatB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tatB</name>
        <name evidence="10" type="ORF">GT040_17045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TatB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000805">
        <property type="protein sequence ID" value="MYW30937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00237">
        <property type="entry name" value="TatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018448">
        <property type="entry name" value="TatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17959" checksum="2AC9BEB1C6149B58" modified="2021-04-07" version="1">MFNDIGALELLTLGVLAVLVFGPDKLPKLIQDVTRTIRKIREFSDSAKEDIRTELGPQFKDFEFEDLNPKTFVRKQLMDGNDDLGLKEIRESFDLRKEIADVTDAVNGRTPAPDSADSAANGSAGAPATTTSPSLTKTGDTTPDLLKKAPQQAQPERPPFDADAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFN1</accession>
    <name>A0A7K2ZFN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_18310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029801505" description="SLT_2 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="3">
        <location>
            <begin position="186"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="337" mass="35118" checksum="85D59E384A91C0F8" modified="2021-04-07" version="1" fragment="single">MKFTGTVRRQLTGTVTAVAAMAALTASQAPGFGDAVAVSREERTASGPDDVVWSEVEGDDAYHTELPPLESPRPPAPLKPPQAVVEPSLPLFARARAEAGIPATVLAAYRNAERSLRRSDSGCRLPWQLLAAIGKVESGQAAGGRVDARGTTLTPILGPALDGVGFALIRDTDNGVHDGDRTYDRAVGPMQFIPSTWANWAMDGNGDGREDPHNIYDAALAAGHYLCAGGRDLGVRADLDRAILSYNRSDVYLRTVLSWLEFYRQGTHPVADGQGVLPTSPGPGGTDRPKAPVGSGPSEKPGKPGGGIVIGPQPPRPPGPKPTPGPTKPGTPSPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFN2</accession>
    <name>A0A7K2ZFN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="30378" checksum="B7546F50D3FAA9D7" modified="2021-04-07" version="1">MTAPMPVRPPEPPERPPPALAKTPEPAPVQRRPSRLLAPLRETGKLFALGIAVGRAIFRRPFQLREFIEQFWFVASVTILPAALVSIPFGAVIALQVGSLTQQLGAQSFTGGASVLAVIQQASPIIVALLISGAAGSAICADLGSRKIREELDAMEVMGVSPIQRLVVPRVLATMLVAVLLNGLISVVGTLGGYFFNVIMQDGTPGAYLASFSALAQLPDLYVSEFKALIFGFIAGIVAAHRGLNPRGGPKGVGDAVNQSVVITFMLLFFVNMVLTAIYLQIVPAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFS9</accession>
    <name>A0A7K2ZFS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="7" type="ORF">GT040_18345</name>
        <name evidence="8" type="ORF">GT040_25060</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000861">
        <property type="protein sequence ID" value="MYW31180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001174">
        <property type="protein sequence ID" value="MYW32450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="28799" checksum="EC76DDD2CE4D3440" modified="2021-04-07" version="1">MNGASREALAAGRERLDALTDSTSVDAAALADDLASVTALLHREVSLRRVLTDPAQSGESKAELAARLLSGQISGEAVDLVSGLVRSRWSQSRDLVDSVEELANTADLTAAQRAGVLDDVEDELFRFGRIVGSDTELRSALTSRTATTAAKGELLRSLLGGKAQPVTERIIVRLVTQPRGRSLEAGIESLSKLAAERRDRAVAVVTSAVPLSDRQKQRLGAALAKLYGREMHLNLDVDPAVLGGISVRVGDEIINGTVAERLEEATRRMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG02</accession>
    <name>A0A7K2ZG02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_18545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000866">
        <property type="protein sequence ID" value="MYW31219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="420" mass="44199" checksum="C8E486ED686665FB" modified="2021-04-07" version="1">MSTSKVTAARHAPKKGGRRKLTLPVVLLIIAGGLALVSLVRLISGADDVTSVGQVAGALELAVPIGLAGLGGLWAERAGVVNIGLEGMMILGTWFGAWAGFQWGPWMGVLFGILGGCLGGLLHAVITVTFGVNHIVSGVAINILAVGVTRYLSNFAFDGVQGGSSKQSPRIDPIDKITIPGLSDWMQDLQQHHWFLVSDIAGIIGGLVTGLSLLTLLALLLIPATWWILWRTSFGLRLRSCGESPVAAETLGVNVYKYKYIAVTISGGLAGLGGAFLAIVATGIYQEGQTGGRGYIGLAAMIFGNWMPGGMALGAGLFGFTDSLKLRGGAENVHAMLLLLAILLVIAVFWQLYKKKYVAAVISAAVSALLFTWYLLTDQVPSQFVDAAPYVTTLLVLSLSAQRLRMPKADGVPYRKGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGC4</accession>
    <name>A0A7K2ZGC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000913">
        <property type="protein sequence ID" value="MYW31413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="40" mass="4106" checksum="7C1E576430853067" modified="2021-04-07" version="1">MADGFPGVVPVRDSKTPHGPALVLPATAWTAFIDVVTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGT1</accession>
    <name>A0A7K2ZGT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="7" type="ORF">GT040_20395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000966">
        <property type="protein sequence ID" value="MYW31571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="322" mass="34457" checksum="9D62C14C47FBAEC9" modified="2021-04-07" version="1">MNDVLDVALRLAIVFVVFLVAPLLVGQTEHKVMAHMQGRLGPMYAGGFHGWAQLVADGVKFAQKEDVVPAAADRRVFQLAPAVALLPYLLVLVAIPVGPGDGAVGQVVDAGIFFVLAVMGIGVLGSLMAGWASANKFSLLGGLRTAAQLLSYELPMLLAAASVAMAAGTVSLTGILDAFEWWWLPWQIVGALVFFVAGLAELQRPPFDMPVADSEIIFGAYTEYTGLRFALFLLAEYAGIVILCALTTVLFLGGWHGPFGADGLGWLWTLLKTALLAFVVIWLRVSYPRLREDQLQRLAWTTLVPLALAQIALTGIVKVAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH06</accession>
    <name>A0A7K2ZH06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000968">
        <property type="protein sequence ID" value="MYW31588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="347" mass="38100" checksum="78A1D356D6C5E6A2" modified="2021-04-07" version="1">MRCTLFGRTGLRVSELALGAMTLGRHESGHAAVRETSGRILDAYLEAGGNFLDTADVYAGGTSETVLGELLGDRRDALVLATKYTCATRPGDVNSGGNHRKNLVQSVEASLRRLRTDRLDVLWVHARDNFTPVEEVMRALDDLVRAGKVLYVGVSDWPAWEIAQASTVAELRGWTAFTGSQLRYSLLERTPERELLPQARAFDQAVFAWSPLARGRLTGRQEEAAVGAADEAEMRARETVGAVVEIARERGWSPASVALAWLRGRPGNIVPILGPSTPDQLTDALGCLDVELDVDAVDRLDTVSRVPLGFPHDFLRDEGVRETVYGDRWTAIEDRRSTYRRTTSGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH07</accession>
    <name>A0A7K2ZH07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_20750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000976">
        <property type="protein sequence ID" value="MYW31641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="7">
        <location>
            <begin position="110"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="36939" checksum="F3DA8F2A7908264F" modified="2021-04-07" version="1">MTNQTPAPEPAAAAELPTASPESDATPDAPLPGPRQPRLTQRTTLRSDLRASWPDGLVALLVTAAVFVLLYIRIRDKTSSTVSVMPFMADAGGFWMYFLSQAFGWSALLWAWGTVILGLLLSGRRPGRLPLSGPRLERLHRTTSLNTIALITAHALLFGAELFRHSTDAWNSALGTAFVETFVPGGYTSGTGQIAIPIGQAALYLAIPLGLLFYVRHRIGPKTWRVLHRFVIVVYVLSVWHTLLYGTNVWYDGWFRTSVWLLQLPIAALLLVRLLRPARRSEKLPLSPGATASRTGWALRLGGRLAVVGVVVALVVVVVSGSDGGRTVPPDDTSSSHNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHN8</accession>
    <name>A0A7K2ZHN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001034">
        <property type="protein sequence ID" value="MYW31873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="201" mass="21253" checksum="85D3E4799EF47E0C" modified="2021-04-07" version="1">ARRAAGRHAGSWGRVHAVLDDSFSSSGSGQKRRRPLAVALACHHLLEVLAAPGAYRGLWTSGRGDALLVRPWGPTPLGMRVLDALEPGPGGAAPDRLVIVSDGWDNAPAGLAGEVLRVWRARLDPGRRTAVVHVNPVYDADGFDVRRLATGVPTAGIRDAEDLPALVEIARFAEGRTGAAELHAYLDRRVALFLGEKGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHY2</accession>
    <name>A0A7K2ZHY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_22285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001060">
        <property type="protein sequence ID" value="MYW31928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029604559" evidence="2">
        <location>
            <begin position="29"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="120"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="599" mass="65366" checksum="36D175991F361D67" modified="2021-04-07" version="1">MKSIRTRSARAAIVALAAGSLVLTGCSGDNGNKNTKDESKSKEDAAAQSKPVQYADATGSTGPAKDVKGATPGGTINVYLQSDLTHLDPGQIYVSDAGQFSNLIHRKLTNYQEDAEGNLTVVGDIATDSGKSSDDGKTWTYTLKDGVKDEDGNVITSADVRHTIERLYSKVIFDGPSFVQSWLSGSDYRKALPDGPYKGKHLPDTVLETPDEKTVVFRFKKAQPDLPQALAMAGYAIVPEKQDTKEKYDKAPKALGPYKLVEYKAGKSMKLVKNTNWDPKTDAVRHQYVDGYDFTTTVEQASQTKRLVADQGEAKNAIQFTTSVDPAQIQDVVGDPKVNARTIKGYQPYVWQLNFNLDRVKDKKIRDAITYALPNAAIVQTDGGKYGGEIAGGLMAPTLPGYDPNYDPFGKQKKPNGDLAKAKELIKEAGVKPGTKISYAYSNTPRGQKQQVIIKDTLGKLGFDVQAKEIDSASFYEQIGKLNNGFDLYATGWGQDWSSPSTVITPVYDGSLIADGASNYSHINDAKVNELIQKALTEEPEQAAKTWEEAHHRIVEEINPAAPLYYSKQLQLFGSNIGGARYSTNSSYININDLFLKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIF9</accession>
    <name>A0A7K2ZIF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">dCTP deaminase</fullName>
            <ecNumber evidence="3">3.5.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dcd</name>
        <name evidence="3" type="ORF">GT040_23420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="19429" checksum="8A517D1CA8FF2404" modified="2021-04-07" version="1">MILTGPEITAAAADGRLRIAPFDQDQVNPNSYNVRLGPTLLTYTTPVIDSHRPNPTMDVRMDEGGFVLQPGELYLGHTLEEVGSDSFVPLLFGRSSVGRLGLFIEITAPIGDIGFHGQWTLMLSAIRPLRVYPGMKIGQIMFFVAVGAVDLYTGKYQAATGPQPSAYWRDNPVFGSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIK2</accession>
    <name>A0A7K2ZIK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dCMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="16959" checksum="039DC581A06C96C4" modified="2021-04-07" version="1">MYAPDRAQDLRWIQRAIDLAALCPPAPGAYSVGAVIVGEDGTELASGYSRATGPREHAEEVALAQLPQDDPRLAGATIYSTLEPCSQRSASRTPCAHRILEAGIPRVVIAWREPSLFVDDCVGYEQLVEAGVVVVELPELAAAAKATNSHLPGLGEEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIS2</accession>
    <name>A0A7K2ZIS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001118">
        <property type="protein sequence ID" value="MYW32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="38"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="222"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="545" mass="57803" checksum="F39008451C3A1426" modified="2021-04-07" version="1" fragment="single">MGGDDREAPRARLPRLRLDELLDELQGRIDEARGTRDRLNGLLEAVMSVGKELALPQVLRGIIEAAVVLVDAEYGALGVIGDDQKLAEFLPIGISDEVREQIGGLPSGHGLLGELIRHPEPLRLAELSAHPTSYGFPPHHPPMHTFLGVPIRVREEVFGNLYLTGKRGGADFDAEDEAVVSTLAVAAGIAIENARLYEEGRQRERWLAASSDFTSALLSGSAESEVLEGMLARAVDIAGADLGVFHLVEPDGELSGSMAHGERAGVHRGLVRPTTRGTLAGATLAADALITVPDVGNDPRITVRPERWDGFGPAVAVVVGTKEKLSGVLILARLQGGPPFAGPEIASLPGFAGQAALALELAERRRAAEQVSLLEDRDRIARDLHDLAIQRLFATGMTLQSARPFVEHPEAAERLGRAIDDLDTTIKIIRSTIFGLREHGPTGDAPGLRTRVVQAVDTAVPALGFTPALRMEGLIDTDVPQDMADQVIAVIVEALSNIARHAGARAAEVSVVAEDGVLTVTATDDGTGLQEGAHGSGLRNLTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIT2</accession>
    <name>A0A7K2ZIT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001121">
        <property type="protein sequence ID" value="MYW32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="190" mass="20504" checksum="48181A3B3FFE654A" modified="2021-04-07" version="1">RDRPRVALTFEGRGDPGLATAALARIERAGARVTVLAVGSWLDAHPSMARRILDGGHEIGNHTQNHRDLAALDERTAYEEITACARRLRRLTGSIGTWFRPSPGPDATPLVQHLARRAGYPHVLSYDVESLDHAATGVPAVLRKVTGELRHGSVVGLSLARPVTVAALPLLLTEIERRGLRAVTATELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ07</accession>
    <name>A0A7K2ZJ07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Wax ester/triacylglycerol synthase family O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001136">
        <property type="protein sequence ID" value="MYW32305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045017">
        <property type="term" value="P:glycerolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="1">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="17308" checksum="8F19255FDAB8D217" modified="2021-04-07" version="1" fragment="single">MGTELLAPLDLAFWHLESDAHPMHLGALAVFAPAPGVTPPHVLELLRTRAAAIPRLRMCVRDVLLPVGGAAWTVDKDFDVHRHVRRVAVDEGDFMAGATRLAGELMEQPLGRGLPPWQMYLIGGADDGPFAVLVKLHHALADGMRAVAIGAGIFDEIAATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ45</accession>
    <name>A0A7K2ZJ45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Betaine/proline/choline family ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_24605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001153">
        <property type="protein sequence ID" value="MYW32361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="383" mass="41553" checksum="D41514A8627FB9AE" modified="2021-04-07" version="1">MSRLQAENLYKVFGRRPDQAVRKLESGTDRDELRADGTTAAVIDASFTVEPGQIFVVMGLSGSGKSTLLRMLNGLLEPTAGRVLFDDQDLTALSPRDLRDVRSTKISMVFQHFALFPHRSVLDNAAYGLEVQGVPRSERIRRATEALELTGLAGWENSWPDELSGGMQQRVGLARALATDADLLLMDESFSALDPLIRRDMQDQLLELQKRLKKTIVFITHDLNEAMRLGDRIAVMRDGRIVQLGTAEDILVTPANDYVASFTQDVDRSRVLTAGAIMAEPHTVMGSTTTDGKELRTPQDVLAAAPATVSESTPIIELFTPCSQSADPVAVTDAKGKLVGVVPSSRLLAVLGDPMTPTEAPKDSGEPRETLSDNDAAKKVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ55</accession>
    <name>A0A7K2ZJ55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_24730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001155">
        <property type="protein sequence ID" value="MYW32386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="912"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="328"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="953" mass="98764" checksum="4AC887260F23783A" modified="2021-04-07" version="1">MNLFSGWRAAFRIARRDAVRAKGRSALVVAMIALPVLGVTAADLTYRSALPTVAEDLTADLGAADALFIDQGMGPVRLEQMPDGVMWGTPEDAPETLPEDERKPVDVPATFPKGSRSLTEQSVPASVTTRHGITDTQITELAVADPLLRGRVELTEGAYPQAEDEIAATDAFLKASGLSVGDRVTVRGPEQAYTLTGAVELPADLKSESLFAVPGAVIAPWQKTADGDKGILPPQAGDRKWLVKGPPGAGVTWSDVRAANEKGVVVRARQVVLDPPPDSEVPMAAQMGGSESGIREMTAAALTVAAMAVLEIVLLAGPAFAVGARRSRRQLGLVGSCGGTRGQVRAVVLAGGVVLGGVGAVVGVGAGFGLTALFRPMIEDFTGRRFGELTVHPWEILAIAVLGLVTGVLAALAPAIVAGRQSVLESLTGRRGSRRSSRVLPVVGSLVLAAGVALAVYGGVSGNINLVAGGSVLAELGLLCCIPVIVGFLGRLGRRLPLTPRIALRDAARNRGRTAPAVAAVMAAVAGSVAIATYTSSSAAEQAYDHEPNLTAGTAVVMAFDTSQKANLPRARAAVEQNYPVNGGRADIGRVWAGSDCSVYYDEEGGGCGTIGLVKPTGEGHSCPLKGKGAKELALRISADEHKRLMNSPACVDERWTMVSLGNDDSKIVIGDAGLLTSYVKLDDPAAAKALDAGTPVLLNPAYAENGEVTLKAVHTYSERDKENRALHPGKARTTTDRLKVYVAPDRYAATPGIRMILPQRTAAELGLHTEDHAGVYTLSREPNDAERQAAAAAIEQSGNRAYVMTANEAEPDDDAAVLLILALFAGVVTLGAAAITTGLSKADAEADLTTLSAVGAPPGVRRSLSGFQCLVVALTGVLLGTLAGIVPAVALRLTDLRAALAEMRVDPMESAYTPIVMPWETIALLALVVPVLAGLLAAALTSSRQKLARRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ98</accession>
    <name>A0A7K2ZJ98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001161">
        <property type="protein sequence ID" value="MYW32411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025751">
        <property type="entry name" value="RsbRD_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14361">
        <property type="entry name" value="RsbRD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="156"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="283" mass="30457" checksum="ABD7140362EB28C4" modified="2021-04-07" version="1">MAKQDRTSDLVGLLSADRERVESEWIDSVAGSLKGRISKAEVDRELRELYAALLEALASGGEDARGENLSETRALLTELSRNRARQGFTPSETAISVLALKKALEPALRDGTAEDTERYLRLSRVLDDLALFTIETYTRTREEIISSQAAQLMELSTPVVKLWDGVIAVPLVGTLDSARTQVVMEKLLQALVDTGSEQAIIDITGVPAVDTQVAQHLLKTIVAARLMGAECTVSGIRPQIAQTIVALGIEFGDIVTKATLADALQLALKKSGIDLVAHQGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJH8</accession>
    <name>A0A7K2ZJH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="290"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="488" mass="53423" checksum="36293A8989794297" modified="2021-04-07" version="1">MNDLVRQHTALSDTDLEWLHLLVSEWQLLSDLSFADLVLWVPTRDGTRYVSVAQMRPNTGPTSYQDDMVGHLVPRGRRPLLDAALDEGRIVREGDPEWREEVPVRVESIPVRREGRVLGVIARNTNLLTVRTPSRLELTYLQSASDLAQMIAAGSFPFPGQQVDMDASPRVGDGLVRLDADGVVQYASPNGLSAYHRLGLASDLVGHHLGTTTAELAPSRGPVDEALVKVASGYAPREFEVEGEGGVIQLRAIPLKPKGVRIGSLVLLRDVTELRRRERELITKDATIREIHHRVKNNLQTVAALLRLQARRMDSEQGREALNEAVRRVGSIAIVHETLSQNLDERVEFDEIADRVIAMVSEISPGKVTCRRTGRFGILDAEVATPLSMVLTEVLQNALEHAFTVADQGTVEVSAVRGGSPTEGRLLITVTDDGRGLPEGFDPQRAGNLGLQIVRTLVEGELGGTFGMVPAPERGTQVVLDLPVRGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJJ0</accession>
    <name>A0A7K2ZJJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">murQ</name>
        <name evidence="5" type="ORF">GT040_25410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001196">
        <property type="protein sequence ID" value="MYW32516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="78"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="33013" checksum="C831C0C5C33AEE85" modified="2021-04-07" version="1">MTSTTDASGTTDASGTDSYGELRAQLATLTTEAFRPELAEIDRLPTAEIARIMNGEDATVPAAVAERLPRIAAAIDAAAERMARGGRLIYAGAGTAGRLGVLDASECPPTFNTDPSEVVGLIAGGPSAMVKAVEGAEDSKELAASDLDALKLTADDTVVGISASGRTPYAIGAVEHARDQGALTIGLSCNAGSALAAAAEHGLEIVTGPELLTGSTRLKAGTAQKLVLNMISTITMIRLGKTYGNLMVDVRASNEKLRARSRHIVSLATGASDAEIEAALAATDGEVKNAILVVLGQVDGPTAARLLTESDGHLRAALAAVRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJM0</accession>
    <name>A0A7K2ZJM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine biosynthesis protein LysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lysW</name>
        <name evidence="1" type="ORF">GT040_25495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01206">
        <property type="entry name" value="lysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="57" mass="6191" checksum="BEB331F7BDFC1079" modified="2021-04-07" version="1">MTTLQACPECQDEVQVDAAVRLNEIVECAGCRSELEIVSLSPTVLALAPEVEEDWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJR9</accession>
    <name>A0A7K2ZJR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_25695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW32571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="451" mass="49893" checksum="B53364E35E0AFD23" modified="2021-04-07" version="1">MSQVHPGDAPLIHDLIGIGFGPSNVAMAIALREHNTRVGGQEPVTAHFFEQQQSFGWHRGMLIDDATMQVSFLKDLVTLRNPSSEYSFLCYLQSRNRLIDFINHKNLFPLRVEFHDYFEWAAAKVDDMVSYGHEVVSVTPFVHDGTVEYLDVTVRSGGGLEVHRARNLVIGTGLRPILPEGVRRGDRVWHNSDLLRKVDGLEGTSPSRFVVVGAGQSAAENVAYLHRRFPEAEICAVFSRYGYSPADDSSFANRIFDPGAVDEYFAAPDSVKSQLMAYHGNTNYSVVDIDLIDDLYRQMYREKVLGTERLRFLNVSRVTAVEERPDSVRTTVKSLVTGEETPLDADIVVFATGYSPADPLGLLGEVADRCLLDDEGRLRVERDYRIATDPALNCGIYLQGGTEHTHGITTSLLSNTAIRVGEILDSLLDRSVKSTSDEARPVTDGTGSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJW4</accession>
    <name>A0A7K2ZJW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001208">
        <property type="protein sequence ID" value="MYW32635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029653962" evidence="1">
        <location>
            <begin position="36"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="497" mass="53675" checksum="F000598032085364" modified="2021-04-07" version="1">MISLHTTRVRRRRLGVAAAAAGLFAALLTAAPAAATPDPGDAPVDRGSVTTGQQAEARAAIRGGDIPGVDEIVHSPNIKHLASVPKGALKGTNTDLAFQGKYAYVGNYDGFVIYDISNPKKPKTVSEVLCPGSQNDISVSGNLLFLSTDSSRSDDSCSSTTQPATEKSSWEGMKIFDISNKRNPRYIAAVETACGSHTHTLVPDGKKNIYIYVSSYSPNETFPDCQPPHDGISIIKVPLKKPQKAKLVSFSNLFPDGGNPGAPQNPGVFKTTGCHDITVLPSEDLAAGACMGDGLLFSIKDPERPKVIDRVQDNVNFAFWHSATFNQSANKVVFTDELGGGGAATCNEEIGPNRGADGIYDIVGKGDQRKLVFRNYFKIDRHQADVEVCVAHNGSIIPVKGKDLMVQAWYQGGISVWDFTDSAKPKEIAFFERGPVTLDQVTTAGPWSAYYYNGHIYSSDIAKGFDVLKLNDRRTDPADRVELDELNVQTQPDYFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKA7</accession>
    <name>A0A7K2ZKA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_26785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001251">
        <property type="protein sequence ID" value="MYW32780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="161"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="225"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW32780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="445" mass="47675" checksum="D72A9A411B50A9DB" modified="2021-04-07" version="1">MKRLALRTGVRWKISIAIAAVGALIAVALSLVVHNAARVSMIENAREVQLERLLGAQRFYEATTMQKGGPKFGAKLNDPAIPPSLRDEVRKNRRATHVTETSDGVPDVWAAVPLANGDVLSLHTRFADRSATIMDDLDRALIIGSVSVVFGGCALGVLIGGQLSRRLRKAAAAAGRVAEGHTDVRVREAVGGVVRDETDELARAVDALTDALNERIEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTELVRDRAQAMRTLVEDVLEVARLDSASERAELQELPLGEFVSRRIGLLDPDVTVQVVHESWVSTDPRRLERILGNLLGNAAKHGSTPVEVTVEGRVVRVRDHGPGFPEELLRDGPSRFRTGSMDRAGHGHGLGLTIAAGQARVLGARLTFRNAAPVGAAEGTGGAIAVLWLPEHAPTATGSFPMLRTADERQPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKD2</accession>
    <name>A0A7K2ZKD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2083 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001252">
        <property type="protein sequence ID" value="MYW32795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018653">
        <property type="entry name" value="ScfR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09856">
        <property type="entry name" value="ScfRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="406" mass="44516" checksum="570820274BC92865" modified="2021-04-07" version="1" fragment="single">MARPAGRKIYAHAKLRRLRRERGMNQVELARALGLSTSYLNQIEHSRRPLTAPVLLRIAEVFGVDPEFFSEADEERLATDLRAALGDEACGTQVPLEEAADVARDHPEVARALVALHRRYRDAAERVVALAPPQDGESLLTAEPHDEVRDFFYAHHNHFGALDAVAERTAADLGTGSAGRTADALKERLAARHGITVVVTDPERAADARRFDPGSGLLLLSPWLSEAQHAFQLATQLALMENGSLLDTLVAGGELASEQAAGLARIGLANYFAGALLMPYTAFHRAAEELRYDIELLQARFGVGFETVCHRLSTLQRTGDRGVPFSFLRVDRAGNISKRQSASDFHFSRLGGTCPLWTVYEAFSAPGRILTQVAEMPDGKRYFWVARTVTRGGFGHRAPRADFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKQ7</accession>
    <name>A0A7K2ZKQ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0303 protein GT040_27515</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0303 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001295">
        <property type="protein sequence ID" value="MYW32923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512440.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001295.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00761">
        <property type="entry name" value="UPF0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="UPF0303"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="entry name" value="PTHR28255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="17088" checksum="64D239B79CA8D446" modified="2021-04-07" version="1">MTTTSPTISELIAQERRLTLPHFSYDDAFALGSLLVALARERHAPVAIDIRRGAQQLFHAALPGSSADNDAWIDRKRAVVERYGESSYLVGTRFRSKGTTFEESSRLDPDAYAAHGGSFPIAVEGAGVIGTVTVSGLPQAEDHAMVVEALEQFTATLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKY4</accession>
    <name>A0A7K2ZKY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001303">
        <property type="protein sequence ID" value="MYW33012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="367" mass="39999" checksum="7BE26B22390A4792" modified="2021-04-07" version="1">MEILLFLLAMCMLAAIVGPWVMRRRGGIRQVAPGSPDAADPDTYGFARQEELDVRMPGPDQDLLDVLDVVQATQEWRAASQLLAGTPKENEVRWQRVQAFAGAASLELAERPGEGGSWLRRWRAEAPKDAGGAAVHAEFLVQQAWRSSSAGTDDFRVILEEARSVCGQAALLAPGDPVPYIVELAVARGLGYTPEQFDQLWAKIIDRAPAHMGAHIAALHFHSERWHGSRKEAEVFATAAAARAPQGSLLAALPLFAVYEHLPEVNLVQGFYRSQVVTRAVEGAMFAVHAARPDDPMLAHVRHLLVLFLVHMERWSEAMHQLVLIDGHVGALPWTAEADPAAQYTVYRALAVAGYEANGGSPATLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKZ3</accession>
    <name>A0A7K2ZKZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001304">
        <property type="protein sequence ID" value="MYW33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_19_cat" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="6895" checksum="586E763B0D71C262" modified="2021-04-07" version="1">WNTQNGPGTMTSHEAMVGGAGFGETIRSLNGALECDGGNPQSVAARVQRYERITGILDVSPGSGLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKZ7</accession>
    <name>A0A7K2ZKZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-HC2 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001306">
        <property type="protein sequence ID" value="MYW33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="18757" checksum="619D6F9EA380A272" modified="2021-04-07" version="1" fragment="single">MSGTGPTGPTPAEAHLGDRLAALVDGELNHDARERVLAHLATCSRCKVEADAQRRLKSAFAMSAAPSPSEGFLARLQGLPGGPGGDDTGSGRPFGSGGPFADEFFPPLRSSDSTRRDSAASPAPLDDFGYFPAAHGSTAVLPGGSRSAFRIHEVARDAERSPWRGRRFAFAAAGAVSLAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL11</accession>
    <name>A0A7K2ZL11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_28125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001307">
        <property type="protein sequence ID" value="MYW33037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="346" mass="35201" checksum="0F637681E918CF4A" modified="2021-04-07" version="1">MTVTAPDQAPAAAIPESGATRLVDRVFRMRELAILLVFLVMIGVTQLGNSAFLSEQGIKDLLLNATILVLVATGQSLVVITKNVDLSVGSTLGISAFAAGTYLQGGGHPVVAVGLAVLLGVGFGLLNGLLVSLGQVPALVVTLGTLYVIRGIDSVWVGSRQITAADLPGGFVDFGSGGISAVPWLALIALAVLMATAYYLKHFGSGRELYALGSNPEAARLAGIPVRRRILLAYTFCGALAGLAGALYLARFGNVDSGTGSGYELTVVSAVVVGGVVFTGGSGSVYGAALGALLLTSVNSVLPALGVSSVWVLAINGLLLILAIAVDRIVALRVATALKKRNARHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL15</accession>
    <name>A0A7K2ZL15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_28170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001308">
        <property type="protein sequence ID" value="MYW33046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029720716" evidence="3">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="292" mass="29961" checksum="4662904344764789" modified="2021-04-07" version="1">MPDRRRRTAFRLPSPARAALLMRERQSSSPDSAPESPDSSSASGSPSPEAPAKPADDNPFAPPPAGRPDQPWQPRHPSGSSPASGDDDEGSGGRSSWGSQWSNKQPGRGGGGFGGRSGSNGPGGKGGPDGSPGGMRWDPTDPIQRRARYALLGGIWSVFFALFDLTEIALLLGALSVYWAVSALRGQPKGPAATERTTVGAVTGAATPAAGDGGASPAPATSQGGGRPQTTAAISGLVTALLALIIVITTYTVQLVYRDYYTCVNDALTKTGAVACNDQLPKPLEPLFGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL60</accession>
    <name>A0A7K2ZL60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9166" checksum="45E48DC683754056" modified="2021-04-07" version="1">MTTATPTGRPLTPAPHHRRRAPALIASGAVLLLGALTQGCAGGRVMAESEFREHMRLTEEAGEEAVRRLGTDPSAFVDGHEMANASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLJ2</accession>
    <name>A0A7K2ZLJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_29200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001355">
        <property type="protein sequence ID" value="MYW33234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="8">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="9">
        <location>
            <begin position="146"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2" evidence="7">
        <location>
            <begin position="217"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW33234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="343" mass="37044" checksum="1728FE64CC140BFC" modified="2021-04-07" version="1">MSDLTTSTATGAGAEGAGDGSVDARLEGHRTELTGYCYRMLGSAFEAEDAVQDTLVRAWRNFDKFEGRSSLRSWLYRIATNVCLDMLSAGNKRARPVDLTGPTPLAQAALSPRPENVWLEPMPDGRILPTVEDPAEAAVARESVRLAFVAALQHLPPKQRAVLILREVLAWKAAEVAELLETSVASVNSALQRARATLTEHEGRVPDAADPLDEEQQKLLERYVKAFEGYDMAALTALLHEDAVMTMPPFDLWLQGASDITGFMTTIGAACAGSRLVPLSANGSPGFAHYKPDPEGGGFVPWAVQVIDVQDGAVSGMHCFLDVERWFPLFGLPERLPAVTAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLJ4</accession>
    <name>A0A7K2ZLJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001353">
        <property type="protein sequence ID" value="MYW33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="16703" checksum="8F3856ACE123DF20" modified="2021-04-07" version="1">MNTPVQPIEVLLVEDDPGDELMTREAFEDNKIRNTLHVVRDGQEALDFLYRRGEYTDAPRPDLVLLDLNLPKYDGRQVLEQIKGDPELALIPVVVLTTSSAEEDILRSYKLHANAYVTKPVDLDQFIAAVRQIDEFFVTVVRLPGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLT4</accession>
    <name>A0A7K2ZLT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001370">
        <property type="protein sequence ID" value="MYW33311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="32514" checksum="A08FB2F47E640AD5" modified="2021-04-07" version="1">MPSNVNPTVRRRRLGQELRRLRELKGMTAEEVAERLLVSQSKISRLENGRRSISQRDVRDLCGVYEVEDVRIVDSLMQMAKDSRQQGWWHAFGDIPYSVYIGLETDAESLRVYEPQMVPGLLQTRAYAEALISGALPEAPPSDIEKRVNVRSRRQDRVNAPDNPLRLWAVIDESALRRRVGDNQVMIDQLEHLVEQSHLPHVTVQVLPFDMGAHPGINGQYAILEFPDAADSSVVYIEGVTSDLYLEKANDVQRYSVMYEHLRAQALNVEQTREFISKIAKSYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM12</accession>
    <name>A0A7K2ZM12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001390">
        <property type="protein sequence ID" value="MYW33404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="37439" checksum="0F1AE7E4412F68CD" modified="2021-04-07" version="1" fragment="single">MSVHSHSAAPNAAAAAPEFPRHVVTAVLVSHDGARWLPDVLAGLLGQERPVQNVVAADTGSADDSARLVTEALGGDRVLHLARRTSFGTAVDEAVRTAGPLTPDDLPYLKRPGGWDPVTRAWVDENYDLPELPHGEPVQWLWLLHDDCAPEPDALAAMLGVVDTDRHAAIVGPKLRGWYDRKQLLEVGVSIANSGRRWTGLDRREQDQGQHDQVRTVLSVSSAGMLIRRDVYEELGGFDRNLPLMRDDVDLCWRAHLAGHRVLVAPDAVLRHAEASARERRPIDCAGRSVAGPHRVDKAGAAYTMLVNARGKALPWVLLRLVVGTLLRTLAYLVGKVPGQALDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMA9</accession>
    <name>A0A7K2ZMA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_30520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001404">
        <property type="protein sequence ID" value="MYW33486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="22205" checksum="28199A6C65DA9BB6" modified="2021-04-07" version="1">MTPTPERRRELLATAAEVFAAQGYNATTVRRIADEAGMLAGSLYYHFDSKESMIDEILSTFLDQLWQGYDAVLAAGLGPRETIEALVTESFREIDRHRPAVAIYQKESKHLATQPRFAYLTDSQAKFEKVWLSTLERGVAEGTFRDDLDIRLTYRFVRDTVWVAASWYRPGGHHSPEEIARQYLSMVLDGIALRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMC9</accession>
    <name>A0A7K2ZMC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001411">
        <property type="protein sequence ID" value="MYW33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512128.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001411.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="20687" checksum="C401343828540273" modified="2021-04-07" version="1">MTVNMTKGQAINLQKSDGGTLTAVRMGLGWQAAPRRGLFGSRTREIDLDASAVLFADKQPVDVVFFRHLVSDDGSVKHTGDNLVGGAGSGGDDEAILVDLQRVPVHIDQIVFTVNSFTGQTFQEVQNAFCRIVDETNGQELARYTLDGGGQYTAQIMAKVHRAGSGWKMTALGNPANGRTFQDLMPSILPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMK5</accession>
    <name>A0A7K2ZMK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="81" mass="8884" checksum="FDAF3AFE10CAFC65" modified="2021-04-07" version="1">MIVKMLHEKGLKAEHAYTAAFVSIGLSIASWCGSMKVEPSGVARADRWGIFVGEWAPTFFGLGLALAHYEHDEDTLHSVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMQ5</accession>
    <name>A0A7K2ZMQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="10320" checksum="B39B3F61A6FFF9BF" modified="2021-04-07" version="1">MTKKSKPTLDEHQDLGRRLAGIRDELSRIQVQLSGAYPQTGAASLPARKLIKAREAIDEARSALDNAVFAEYPESAETTVYYPHPEDRVPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN14</accession>
    <name>A0A7K2ZN14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001451">
        <property type="protein sequence ID" value="MYW33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="2">
        <location>
            <begin position="79"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="31976" checksum="368D39411610275D" modified="2021-04-07" version="1">TGAAGLADRLPDADVLLVWDFTSDAVRAAWPGPGARPGWVHTASAGVDRLLCPELVASDTVVTNARGIFERPIAEYVAGLVLAFAKDLPTTLALQRERRWHHREGQQVAGSRAVVVGAGPIGREITRLLHGLGVQVALVGRTARRTIHGVEDLGPLAARADWVISAVPLTPSTYGMFDTRFFGLLQPSARFINVGRGASVVEADLVSALERRWLAGAALDVFDAEPLGEDSPLWDVPGLLVSPHLSGDTVGWRDRLGEQFVAMYELWADGGPLPNVVDKQRGYVPSTDNSAEEEGASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN53</accession>
    <name>A0A7K2ZN53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coagulation factor 5/8 type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_32090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001467">
        <property type="protein sequence ID" value="MYW33785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029640734" evidence="3">
        <location>
            <begin position="38"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="30"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="27744" checksum="9F2B5E854840864E" modified="2021-04-07" version="1" fragment="single">MPSLRRPSLRRPALTLTLAALLASSLTVIAAPTEARAADPLISQGKPATASSQEGDGLSAAQAVDGDLTGTRWASQWSDPQWIRIDLGKRSDLSRAVLTWEGAYGKAYEIQVSDNGTDWTTIRKVTDGDGGTDDLALTGSGRYVRMLGTARPGGYGYSLWEFQVYGTQGDTPPPAGGAVKVTGSQGAWRLTVGGQPYTVKGLTWGPSMADAPRYMPDLKSMGVNTVRTWGTDASTKPLLDAAAANGLRVMNGFWLQPGGGPGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNI9</accession>
    <name>A0A7K2ZNI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001496">
        <property type="protein sequence ID" value="MYW33916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="24523" checksum="B676DE0E64A34BF6" modified="2021-04-07" version="1">MSFLTLGHRGVMGVEPENTLRSFVRAEEAGMDAIELDLHLSKDGALAVMHDADVDRTTDGTGPIAGKTLAELRELDAGKGERIPVFEEVLDAVKAPLQAEIKDVAVARALAEVILARDLVGRVEVSSFHDEAVTEIARLVPGVRTVLIASRWGGDIVERARAAGAPTLALNIRRLTLEVVEQAHAESVKVIGWVVNTQDHLRLARALNLDGATTDFPEIRRTGRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNL6</accession>
    <name>A0A7K2ZNL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001503">
        <property type="protein sequence ID" value="MYW33961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="13945" checksum="B6F8C32ABE3FA3A9" modified="2021-04-07" version="1" fragment="single">MTDAPSPAPTPEAYVLGVDSGGSGLRVALGRVDTDGPLFTAVCAEPVRTGVGGIDAAHLLEQLLPAAAELLERAGAGGTADSSGQVSPGQVAAFAIGAAGMATLGGRLRAELPGALAEALGVRRMALAADAVTAYAGAVGQRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNM1</accession>
    <name>A0A7K2ZNM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001502">
        <property type="protein sequence ID" value="MYW33945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="7671" checksum="A336F7EB8F67C78C" modified="2021-04-07" version="1">AASLVVALLAGAGAGIAVGGFTEYGGQGALLGLAAGVSALIGLRVASYDYPSRFVHMTAGVALPLTAAAPAVYLIGRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNR7</accession>
    <name>A0A7K2ZNR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001494">
        <property type="protein sequence ID" value="MYW33909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="644" mass="69240" checksum="29B0BC0E55E89D9A" modified="2021-04-07" version="1">MKEAGRSNAAGPEDVVSDTQTLIDNRPPSVAALFIDRVAATPDGEAYRYPVPSASGEGPDDWKSLSWGQAAKRVYAIAAGLIALGVQPEERVALSSATRVEWILIDLGVMCAGAATTTVYPSTNAEESAFILADSGSRILIAEDAEQLAKARERRTELPDLAHVVVIDPAGVEPAQGDPEGWIITLDDLEARGDELLAKTPDAVTDRVSAITADQLATLIYTSGTTGRPKGVRLPHDNWSYMAKATVATGLITAEDVQYLWLPLAHVFGKVLTSGQIEVGHVTAIDGRIDKIIENLPVVQPTYMAAVPRIFEKVYNGVASKARAGGGAKYKIFQWAAGVGREYAKVSQDNFRRTGKASVPFALGAKHKVADTLVFSKIRDAFGGRLRACISGSAALAPDIGFFFAGAGVHILEGYGLTESSAASFVNPGEAYRTGTVGKPLPGTEVRIAEDGEILLRGPGVMEGYHKLPEKTEEVLESDGWFHTGDIGELSADGYLRITDRKKDLIKTSGGKYVAPAEVEGQFKAVCPFVSNILVHGADRNFCTALIALDGPTILNWAAENGLEGKEYAEVVAAPQTVELIDGYVQRLNEGLQRWQTIKKFRLLPRDLDVEHGELTPSLKLKRPVVEREYQGLIDEMYAGSREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP40</accession>
    <name>A0A7K2ZP40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001539">
        <property type="protein sequence ID" value="MYW34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029454019" evidence="1">
        <location>
            <begin position="31"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="257" mass="26239" checksum="9C0D79E9D0C3EC1D" modified="2021-04-07" version="1">MNRHRVTARAAVVALLATGLAASPAVAAPAATGAKAHVGADWAKQSITFTAAPGQVNDLHVVPMDQGDGVRRIGFRDAVPLQPGDHCTYLEPGVETYVVCELPTGSSRPDRIDVFLGDGDDEIVTSDPGVATVSGGPGDDTLHAHTAHTVRGDAGDDMVMGRVVLDGGDGMDHLMGDDGDQRMWGGRGDDMIEGYGGRDLVYGGSGDDHIMGGDGEDVLLGGPGDDMLHGEAGDDVIVGGPGKDMADGGPGRNLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP61</accession>
    <name>A0A7K2ZP61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_34045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001551">
        <property type="protein sequence ID" value="MYW34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="21340" checksum="6BBC7AE0CCC80CB3" modified="2021-04-07" version="1">MAGPISMEPGTARPPERPMRADARRNHERLVGVARTAFAEHGTDASLEDIARQAGVGIGTLYRHFPHRHALLNAVFQDALRSLLHRSRELAGAEAPCRALVDWLGAIVAHAGEYRGLARALMSASQDKTSALTQCHLPLREAGAGLLRRAQESGSVRADVSIDDLLQLTNAIALAAEQSPDDPELAGRLLRLTLRGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ43</accession>
    <name>A0A7K2ZQ43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001617">
        <property type="protein sequence ID" value="MYW34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="19713" checksum="8A591ECDB3BC4F22" modified="2021-04-07" version="1">LIAQMTQRLEAAAQAVPALVPYVPALRTTFDAVTALGHRGGGWAQQRVHGDLHLGQALRSPDGFWSLIDFEGEPARPLDERRRPAPPVRDVAGMLRSFDYAARSHRPWNPEWAARCRAAYCEGYALASGTDPRGEPELLRAHETDKAVYEVVYEARHRPDWLPVPMAAIQRLAQSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ61</accession>
    <name>A0A7K2ZQ61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001631">
        <property type="protein sequence ID" value="MYW34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="31106" checksum="90DA6B52D3D205E5" modified="2021-04-07" version="1" fragment="single">MTATGLRIVGAVRISRYTDASTSPEVQEETVTATGARVGGAFVGWARDLDISALKTTPWERKELRYWLDRPDEWDVLIWQRMDRAVRSMADMADLGRYAKKHGKRLIFASGPGGDKLELDFSSPMSELIMLILAFAAQLEGQTIMERNQGAAAHLQSMGRWAGGMIPYGHAPGRYVFPDGNEGWWLFEHKDKDPTRSTADIRRAMVARAIAGRTYSEILRWLEEMGAITPENHRALLATPPREIDPESRWGLTSVRDMLLSPIMRGHIVKKDGTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQJ4</accession>
    <name>A0A7K2ZQJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_36510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001661">
        <property type="protein sequence ID" value="MYW34636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="374" mass="37616" checksum="2EC456B183D898B0" modified="2021-04-07" version="1">MFFALDGFLFAGWVVRIPAIKQQTGASASTLGLALLGVSAGAVITMMLTGRLCRRYGSHAVTVACGILLPLSIALPAQTHSALSLGLVLLVFGAAYGGMNVAMNSAAVDLVAELRRPVMPSFHAAFSLGGMVGAGLGGLVAGGLSASTHLFLLAGIGLLVTAFAGPALLRHRPARTAPAARTPQRQPHRKLDPRARRIVVLFGVIALCTAYGEGALADWGALHLEQDLDAHPGLAAAGYALFALTMTIGRLTGTLLLERLGQTRTLVLGGAVAAAGMLLGALAPTAWLALAGFAVTGLGLANIFPVAVGRAGKLAGPSGVAAASTLGYGGMLLGPPAIGFLADWFSLPIALTTVALLAAAAAALGYGARNATHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQW2</accession>
    <name>A0A7K2ZQW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001684">
        <property type="protein sequence ID" value="MYW34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="52423" checksum="579C17DEB399ECA4" modified="2021-04-07" version="1">MNKPLRRIAIFCGILMLALMVRTNYLQYVRADELNTRDENRRIRIERYAHERGNIIVDGKAVTGSVETNGSDFTYKRVWKDGPLWAPVTGYSSQAFDSSQLENLEDGILTGNSDQLFFNRTLGMFTGDKKQGGNVVTTLDGAAQKAAFKGLGDKKGAVVALDPQTGAILALASTPSYDPSVFAGNSNKDSEAREKLLKDKDKPMLNRALRETYPPGSTFKVVTAAAALENGLYDDIDAKTDSPLPWTLPQTQIPLQNEGNIPCKDASLREALRVSCNSVFGKISDDLGNKKMIEQTDKFGFNKEVFTPVRADASIYPEDNKPQNAMAGIGQASNRTTPLQMAMVASAIANDGKLMKPYMVAKRQAPNLDDIYTAEPEELGRALSGENAQKVQQMMETVVKDGTGTRAQVPGVTVGGKTGTAQHGLNNSEKPYAWFISYAKTDNGSPVAVAVVVEDGNANRDDISGGGLAAPIARDVMKAVVDGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQZ8</accession>
    <name>A0A7K2ZQZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="1">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_37225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monomeric-type IDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001686">
        <property type="protein sequence ID" value="MYW34772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009407">
        <property type="entry name" value="IDH_monmr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00178">
        <property type="entry name" value="monomer_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="82"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="583"/>
            <end position="584"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="599"/>
            <end position="601"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="740" mass="78986" checksum="EE623E13617AADD3" modified="2021-04-07" version="1">MTDSTIIYTHTDEAPALATYSFLPVVEAYASTAGVTVERRDISLAGRIIASFPEHLKAEQRIDDALAELGELARTPGANIIKLPNISASIPQLKAAIAELQEQGYALPDYPDDPQTDTDKDVRARYDKVKGSAVNPVLREGNSDRRAPASVKNYAKAHPHRMGAWTADSKTNVATMGVDDFRSTEKSAVIAEDGSLRIELHGDDGTTTVLRESVPVLKGEVVDAAVMRVAALREFFTAQVARAKAEGVLFSVHLKATMMKVSDPIIFGHAVRAFFPNTFAKYGEQLTAAGLTPNDGLGGILKGLDSLPGVGAEIQASFEAELAEGPALAMVDSDKGITNLHVPSDVIVDASMPAMIRTSGHMWGPDGNEADTIAVLPDSSYAGVYQVVIDDCRANGAFDPATMGSVPNVGLMAQKAEEYGSHDKTFEIPATGTVRVVDAGGNAVLEQAVGAGDIFRMCQTKDAPIQDWVKLAVTRARATGNPAVFWLDGTRAHDANLIAKVTTYLADHDTDGLDISVKSPEEATAFSLERIRRGEDTISVTGNVLRDYLTDLFPILELGTSAKMLSVVPLMNGGGLFETGAGGSAPKHVQQLVKENYLRWDSLGEFLALAVSFEHLATTTDNARAQVLADTLDRATGTFLNEDKSPSRRLGGIDNRGSHFYLALYWAQELAQQTDDAKLAEAFAALAKTLAEQEETIIAELVAVQGSPAEIGGYYQPDPAKAEAIMRPSATFNKAIASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR54</accession>
    <name>A0A7K2ZR54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001697">
        <property type="protein sequence ID" value="MYW34835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15804" checksum="BF24F04BD2783B5F" modified="2021-04-07" version="1">MPAVAITSFGYLHGPQPDARACYDLRHQFRDPHLRPELRYLTARDAPVREAVMATDGVLALVHAIAATVDAYLAGPRQDEPLTIGLGCAGGRHRSATVADALAAVLSGDTETAAAYRVADLADRYKERGLAVDVHHRDLDKDVVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRH8</accession>
    <name>A0A7K2ZRH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001740">
        <property type="protein sequence ID" value="MYW35000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="101"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="27320" checksum="7C1FA211487B2862" modified="2021-04-07" version="1">RVAALRRRGRGCCVVAPIVLHGRAWGELYVARQAGKPVFDRDDANFATVLAAVVASGIAQTERLEEVRKLAFTDPLTGLANRRAVDIRLDEAVEAHRTAGVVVSLVVCDLNGLKAVNDTHGHAVGDRLLERFGSVLSLCGAMLPDALAARLGGDEFCLVADGPEADDVVGVATELCDRAAVIELGNGVACGVASTGDPIGPVRSARRLFRLADAAQYRAKAARSLRPVVAGRDGEVIRLADSPPKSAHDRRRLRGNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRL2</accession>
    <name>A0A7K2ZRL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001736">
        <property type="protein sequence ID" value="MYW34986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="15135" checksum="05F8B28285406C32" modified="2021-04-07" version="1">LVCAAGYTEGGRLARVMPGWQVIGWALILCLPLAVAGSAVAVPLEPVHLTAHGVLGLVWVAAGSTFFGLFVWYKGMAGIGVPRASQLQLAQPLLTLAWSFLLLGEEVSAAAPLAAVAVLVCIAATQRTGRRGRAAPRPAGETGPLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSA8</accession>
    <name>A0A7K2ZSA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001829">
        <property type="protein sequence ID" value="MYW35274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046038">
        <property type="entry name" value="DUF5996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19459">
        <property type="entry name" value="DUF5996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="35247" checksum="66BF98B207FF780B" modified="2021-04-07" version="1">MSERTHAWPTLDHDELASMVGYVNRVVQVAGKYTLDAPFEVGWGNTVLDVTPRGLRTPTFRQPGVAFTVHYRLLDGDVVIEADTGSRTVSLAKGSVASFFEEFCDAAAELGVDRPRTTRVCEIPDCAPTFQGDRAERTWDPRAARLMWEAWNIATGGLEAWQAPFRGNHPRVGVMWGGFDLSATRHSTRPTEPSPGRPAFQRNAQLSAYVAVGFAFGDASAPQAGMYAYIWPAPDGLEDRSWGVEGAAWHADAGLVLLPWDRLGETADPHRSIVAFGDAVYQAAVDLAGWPAEFVGPRVDGWYMSRTPPERVRAAEKAHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSF3</accession>
    <name>A0A7K2ZSF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_40095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001833">
        <property type="protein sequence ID" value="MYW35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="35407" checksum="DE755DAAF0EAFF34" modified="2021-04-07" version="1">MTTPTTALKAPAPGASGAGAGTPAARPPRRGRSVSPRGHSGWTPWLYLLPALVLLAGLLVYPIYQLGLISFLEYTQAQVSGGEPTTFKGFGNYATLFNDSQFWQVLLATVLFAAACVVSTLAVGCALAVLLTRVRALPRLVLMMAALGAWATPAITGSTVWVFLFDPDFGPVNKVLGLGDFSWTYGRYSAFALVLLEVLWCSFPFVMVTVYAGIRAIPTEVLEAASLDGASQWRIWRTIMAPMLKPILIVVTIQSIIWDFKVFTQIYVMTNGGGIAGQNLVLNVYAYQKAFASSQYSLGSAIGVVMLVILLAVTLVYLRLVRRQGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5V0</accession>
    <name>A0A7K2Z5V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_00125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000002">
        <property type="protein sequence ID" value="MYW27718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="4">
        <location>
            <begin position="107"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="405" mass="42971" checksum="8D8715F4C7DFD702" modified="2021-04-07" version="1">MSSENADAGRENEESSAVWDVVVVGAGPAGASAAYAAAVAGRRVLLLEKAELPRYKTCGGGIIGFSRDALPPGFELPLKDRIHAVTFSLDGKFARTRRSRRMLFGLINRPEFDAGLVEEAQKAGAELRTGVSVVRVEQHGPAVPDRRTVAVVLAGGETVLARAVVGADGSAGRIGAHVGVKLDQVDLGLEAEIPVPATVAEDWAGRVLIDWGPMPGSYGWVFPKGDTLTVGVISARGDGAGTKRYLEDFIARLGLAGFEPSISSGHLTRCRSDDSPLSRGRVVVCGDAAGLLEPWTREGISFALRSGRLAGEWAVRIAEAHDAVDARRQALNYAFAIKAGLGVEMGVGRRMLKLFERRPGVLHAVLTGFRPAWKAFAGITRGTTSLAELVRTHPLAQRALNAMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6F0</accession>
    <name>A0A7K2Z6F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type III polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_01160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000056">
        <property type="protein sequence ID" value="MYW27916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="4">
        <location>
            <begin position="212"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="372" mass="40420" checksum="4A1EEFD509C88ABC" modified="2021-04-07" version="1">MATLCRPAIAVPEHVITMQQTLELARETHHGHPQRDLVLRLIRNTGVQTRHLVQPIEETLKHPGFELRNQVYEAEAKTRVPEVVRQALANADTDPDDIDLIVYVSCTGFMMPSLTAWLINTMGFRPETRQLPIAQLGCAAGGAAINRAHDFCRAYPDSNVLIVSCEFCSLCYQPTDIGVGSLLSNGLFGDAVSAAVVRGQGGTGMKLERNGSHLVPDTEDWISYAVRDTGFHFLLDKRVPGTMEMLAPVLKDLVDLHGWSVPAMDFFIVHAGGPRILDDLCHFLDLPMEMFRYSRATLTERGNIASSVVFDALARLFDDGGAAESAQGLIAGFGPGITAEVAVGSWTHHDPAADPDRELADLELKAGVALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6F3</accession>
    <name>A0A7K2Z6F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000055">
        <property type="protein sequence ID" value="MYW27908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="23663" checksum="C9F4134B53F05F71" modified="2021-04-07" version="1">MEELAKEAGITVRTLRFYRERGLIPPPRREGRIAWYDDHHLARLRTITGLLERGHTLNGIADLAATFESGRDVAEVLGLGEPTEETPVRLTPEQLADYFEGEVTPENLATALDLGYLATDGDEIVHISRRLLEVSAELVREGVPLATVLSSGRRVREHADALAEIFVRVLHAHATETEPAQLRPLARAVVDAELSMALDRRLRREDGTQPPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6H2</accession>
    <name>A0A7K2Z6H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000058">
        <property type="protein sequence ID" value="MYW27940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029722202" evidence="1">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="51"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17114" checksum="074A094D19FACFBE" modified="2021-04-07" version="1">MVMTSATTATAVNSVLRVPPASPAEAAAYFGASFAFHADVSDVASALAADGDPGFVVVDSRSTASWDQGHIPGAVHLPTALIPEQAPRLLDPAVPVVTYCWGPGCNGATRAALALAQLGYQVKEMLGGFEYWAREGFAFETWEGGERRAADPLTAPVDDDADCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6X3</accession>
    <name>A0A7K2Z6X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_02110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000099">
        <property type="protein sequence ID" value="MYW28096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029696044" evidence="4">
        <location>
            <begin position="40"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="5">
        <location>
            <begin position="58"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="6">
        <location>
            <begin position="436"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="614" mass="64273" checksum="B45A06B1BFA85164" modified="2021-04-07" version="1">MPHRTSRRTLLTATAAATAAAATGVLPLAGTASAHPADASTNASTDRRLRRIIAGMSLEEKVGQLFVMRVYGHSATDPDQADIDANLKEIGVRTAAELVSAYHVGGIIYFTWAHNTRDPHQIADLSNGIQQAALGEGSRVPLLISTDQEHGIVCRVGEPATLLPGAMALGAGGSRSDTRRAAWIAGAELAALGINQNYAPDADVNVNPANPVIGVRSFGSDPQAVAELVAAQVKGYQGAGVAATAKHFPGHGDTSTDSHTGLPVIEHTRQEWEELDAPPFRAAIRARIDSIMTAHIVVPALDPSEDPATLSRPILTGILREELGYDGVVVTDSLGMEGVRTKYGDDRVPVLALLAGVDQLLNPPNLSVAWNAVLEAVRGGEISEARVEESVLRILRLKSKLGLFRDPFVSGRGVDRTVGIRKHLLDADRIAERTTTLLADPGALLPLSRRTHRRLLVVGADPASPSGTTGPPTATLAGAFAELGFAAMVLSTGTAPNQAKIAEAVAAAQGRDAVVVATYNITTGSTQRTLVDALVATGVPVVAVAIRNPYDAAHLTGRGVAAVLASYSWTDVELRAAARVIAGRARPEGRLPVPVQRADDPARVLYPVGHGLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Z1</accession>
    <name>A0A7K2Z6Z1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">clpX</name>
        <name evidence="10" type="ORF">GT040_02220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000102">
        <property type="protein sequence ID" value="MYW28117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="432" mass="47351" checksum="B8696D51FD3DEF38" modified="2021-04-07" version="1">MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAETSEVRWEELPKPREIYEFLEGYVVGQEPAKKALSVAVYNHYKRVQAGENGGGAGREDAIELAKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFSGLEKIIESRAGAKGIGFGATIRSKLEIQASDQFQEVMPEDLVKFGMIPEFIGRLPVLTSVHNLDREALLQILIEPRNALVKQYQRLFELDGVELEFEREALEAIADQAILRQTGARGLRAIMEEVLQSVMYEVPSRKDVARVVITPDVVRNHVNPTLVPREPRTIGKNDGGRHEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7J8</accession>
    <name>A0A7K2Z7J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8640" checksum="D840CCA1E72E63D0" modified="2021-04-07" version="1">MVLEEADDTGEDGLSVTRVMVNGVDVGRLARAPKINVGTKHDRSLTTVTITLVPARLEIKGEHADGDRREPRAGFTAKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7N2</accession>
    <name>A0A7K2Z7N2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12530" checksum="00C4EDC36BC39560" modified="2021-04-07" version="1">MTTYGPAPIDLLNDSPAVRDYKAGAGWLWYALRNAGMTDEQIANSLATYDASVKRVALEDAADLIRDASLGHYPSGMCPAVSTAKGAASLIDPRIDSPEYLTAAIERAREAWKGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7W6</accession>
    <name>A0A7K2Z7W6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000155">
        <property type="protein sequence ID" value="MYW28403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="9236" checksum="401C2F23D412B2A6" modified="2021-04-07" version="1" fragment="single">MVVRAAVAGASGYAGGELLRLLLAHPGVEIGALTGHSNAGQTLGSLQPHLRPLAGRVLEPTSAEVLAGHDVVFLALPHGQSAAVAEQLGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z894</accession>
    <name>A0A7K2Z894_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_04470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000199">
        <property type="protein sequence ID" value="MYW28543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="4">
        <location>
            <begin position="42"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="366" mass="39528" checksum="A49F32483803EA57" modified="2021-04-07" version="1">MRSGARQSAATATVHEHITDAVKTPDLIRLDGDVVLARFETMKVYAALGAVRSLLRRGRVVPGQTLVDSSSGIYAVALAMACHRYGLRCHIVASTTVDATMLAQLEILGATVDKMPPSQSLRLDQELRVRHVRQLLAERPDFHWMRQYHDAVHHEGYREFAELLDASLPEGPLTVVGAVGTGASTGGLARALRESGRAVRLVGIQPFGSVTFASEQFSDPEAIIAGIGSSIPFGNVHHELYDTVHWLDFRHAMAGAVGLLRRHAVFAGLSTGAAHLAASWEAARDPGRPHLVLGADTGHRYAERVFTRHAEALDPAGLRPRPIASLDALRPPWSVMEWGRRAAPEAARLPEQGGAPAPVPTVEMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8F8</accession>
    <name>A0A7K2Z8F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Catalase</fullName>
            <ecNumber evidence="10">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_04840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="10"/>
    <dbReference type="EMBL" id="WWKE01000213">
        <property type="protein sequence ID" value="MYW28611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase-rel" evidence="9">
        <location>
            <begin position="97"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="17918" checksum="58E8771F2DDA9439" modified="2021-04-07" version="1">GIGPSPDKMLQGRLFAYGDAHRYRVGINADHLPVNRPHATEARTNSRDGFLYDGRHKGTKNYEPNSFGGPVQTDRPLWQPVPVNGATGNTEAPAHAEDDDFVQAGTLYRLMSEDEKVRLIDNLAGFISQVSRDGIAERAIDNFRQADGDFGKRLEAAVQALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Q9</accession>
    <name>A0A7K2Z8Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000248">
        <property type="protein sequence ID" value="MYW28726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19206" checksum="3028E3E2322F8D16" modified="2021-04-07" version="1" fragment="single">MTLDLHKLEHLVAVAEEGGFTRAAERLHLSQQALSTSIRTLERYVGVQLLDRGHQHVTPTPAGQALIDDARALQAQAHAALERARRIGRGQAGHLRIGHTPAVTAEEVVDLLTRARTEEQGIQAQVRQLFPDELRDQLLTGACDLGLSRSMPADTGLTRARIAEHRLRVAVPAGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8T0</accession>
    <name>A0A7K2Z8T0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">GT040_05665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="107"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="379" mass="40904" checksum="E5B1C2E060AD4166" modified="2021-04-07" version="1">MTFPVVGMVGGGQLARMTHEAGIPLGLKFKLLSDTPQDSAAQVVSEVVIGDYRDLDTLRAFAQGCDVITFDHEHVPTEHLRALEADGIPVRPGPDALVHAQDKGVMRAKLTEIGAPCPRNRIVSDPADAAAFAEEVGGFPVILKTVRGGYDGKGVWVVRSEADAADPFRAGVPVLAEEKVDFVRELAADIVRSPHGQAVAYPVVESIQVDGVCDTVIAPAPGLSEELAGEAQQLALRIAAELGVVGHLAVELFETRDGRILVNELAMRPHNSGHWTMDGAITSQFANHVRAVLDLPLGDPRPRAPWTVMCNVLGGDYPDMYQAYLHCMARDPQLKIHMYGKDVKPGRKVGHVNTYGDDLADVRERARHAADYLRGTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8V4</accession>
    <name>A0A7K2Z8V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="12904" checksum="FA5821762E7090A4" modified="2021-04-07" version="1">MPIATLGAVVLECPDPLALARFYAAVIGGTIKDDGGRWVDLVDAPGTPLAFQAAPGFVPPQWPRPDSSMQFHLDLTVEDLDAAEREVLALGARPLDTEDRKRAFRVYADPAGHPFCLCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9D7</accession>
    <name>A0A7K2Z9D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4429 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000300">
        <property type="protein sequence ID" value="MYW28953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027860">
        <property type="entry name" value="DUF4429"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14472">
        <property type="entry name" value="DUF4429"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4429" evidence="2">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4429" evidence="2">
        <location>
            <begin position="137"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="296" mass="31561" checksum="1AE0CAB6D0E13940" modified="2021-04-07" version="1">MAEIIQRDGTWTFDGETVRIVPGGKAHPLRLALGELAVPVEALAGISFEPDRKGGRLRLRLRGGACPVLRAADGRLKDGTDPYVLAVEKDRTGVAEYFVDEVRNALLIEQVPEGPVDRFLLAGPSLPVSGGGGDGTASFDGETVRLTWNWKAEESKTASGPAAFPLARIAGVRWMPSMGLENGYLRFEPVDGPVSAPPKYDPYSLELWGLSKKEYTAVVVAAAVLARLPQARTAVDAPAGTPALTKAPAPAPAAVPAADDHDVLLRRLRELGELHRAGVLTDEEFSTAKQAILSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9S0</accession>
    <name>A0A7K2Z9S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Condensation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000343">
        <property type="protein sequence ID" value="MYW29106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="190" mass="20518" checksum="65C2C2B9DC7D361B" modified="2021-04-07" version="1" fragment="single">MTATHSARPYAAGRLPRVPFPVVDEVDRHCAQDAEPSTIHIEVHLPGRLDEDRLRTAFAASLARFPRALMRERPRGPLARRYEWELTDGPDRDPVSFLPPAPGALDRARAASLAVAPPLTLSPPLRVEVVEEPDREGCVLVFTVHHTALDGPACLRLAATAAEIYSGRSLPPPSAPARPAAAPPPRHSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9X3</accession>
    <name>A0A7K2Z9X3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">clpB</name>
        <name evidence="13" type="ORF">GT040_07520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000355">
        <property type="protein sequence ID" value="MYW29129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="414"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW29129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="861" mass="94119" checksum="1952E50B02477F9D" modified="2021-04-07" version="1">MDAELTNKSRDAINAATDRAVKDGHPDLTPAHLLLALLSGEDNENITDLLAAVEADQAVVRGETERLLGALPSVTGSTVAPPQPNRELLAVIQDAAQRAKELGDEYLSTEHLLIGIAAKGGRAGEILDGQGAGAKKLLAAFETSRGGRRVTTPDPEGQYKALEKFGTDFTAAARDGKLDPVIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVPESLKNKRLVSLDLGAMVAGAKYRGEFEERLKTVLSEIKESDGQIITFIDELHTVVGAGAGGDSAMDAGNMLKPMLARGELRMVGATTLDEYRERIEKDPALERRFQQVLVAEPSVEDTIAILRGLKGRYEAHHKVQIADSALVAAATLSDRYITSRFLPDKAIDLVDEAASRLRMEIDSSPLEIDELQRSVDRLRMEELALKNESDAASKQRLEKLRRDLADKEEELRGLNARWEKEKQGLNRVGELKERLDELRGQAERAQRDGDFDAASKLLYGEIPGLERELEEAAEAEQEASKDTMVKEEVGPDDIADVVGAWTGIPAGRLLEGETQKLLRMESELGKRLIGQSEAVQAVSDAVRRTRAGIADPDRPTGSFLFLGPTGVGKTELAKALADFLFDDERAMIRIDMSEYGEKHSVARLVGAPPGYVGYEEGGQLTEAVRRRPYSVVLLDEVEKAHPEVFDILLQVLDDGRLTDGQGRTVDFRNTILILTSNLGSQFLMDPLVKPEVKKEQVLEVVRASFKPEFINRLDDLVVFSALDGDELAHIAKLQVDRLAARLADRRLTLDVTPEALAWLAEEGNDPAYGARPLRRLIQTAIGDRLAKEILSGEIRDGDTVRVDRAEDGLIVGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9X6</accession>
    <name>A0A7K2Z9X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000357">
        <property type="protein sequence ID" value="MYW29166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="11235" checksum="9F0A0E1965901A10" modified="2021-04-07" version="1" fragment="single">MTPALFGRDHPAGILRSEIVRATESHGGLVLVTGEAGIGKTTLVTDAAHEARRRGTLVVGGSCWDSDSTPGYWPWVQVLRGLRRSATAAEWAAAQDAADGRLGILLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA42</accession>
    <name>A0A7K2ZA42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000370">
        <property type="protein sequence ID" value="MYW29237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014820">
        <property type="entry name" value="PriCT_1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00942">
        <property type="entry name" value="PriCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PriCT_1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="84" mass="8980" checksum="6E2747D39732F6BE" modified="2021-04-07" version="1">HPGHPGKETPAGRRGEGLIQFVLAAHEGQRNTRLFWAACRAYEHGFGDALADALTTAAIRTGLTEQEARAAIASAERLTRGRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAB8</accession>
    <name>A0A7K2ZAB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000387">
        <property type="protein sequence ID" value="MYW29307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="12906" checksum="148360A5EA9DCFF5" modified="2021-04-07" version="1" fragment="single">MLELTRITAGYDRRAPVVRDVSLSVGHGEAVGLLGPSGCGKSTLAKVAALLHRPDAGTMTLDRTVVRGWRHHAPREQRTAVGVVFQQPRLSADPRLSLRELIAQPLRSTGRRREVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAI3</accession>
    <name>A0A7K2ZAI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="9270" checksum="357F7533F4313843" modified="2021-04-07" version="1">MLLTLVFTSGSENTVERKVFFGSMMFKTVEQDGGALDVTAGVENPIPLFVLFLVTTIVLTMIQAIYQGLKRRRDQLLKEMPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAK4</accession>
    <name>A0A7K2ZAK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000405">
        <property type="protein sequence ID" value="MYW29374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23983" checksum="E055FCF50D3CF5C7" modified="2021-04-07" version="1">MTTTFPSISISTDRLVMRPFEMADIPAYIEMMNDEAVVAWTDGPHPYTQVDAERWVRRIAPGERTSGRGIALAVTEFLTQRLVGSVQLLNTDRRTLATEVRYITAPWARGEGYATESVLAVAEWLFRDQGFERIELRTPADNTASQQVAQKLGCISEGVLRNARIARTRTENGTDGGWTDIRTDLIVWGLLPEDLEGVAEQLADAGGYGTYNDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAK7</accession>
    <name>A0A7K2ZAK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiD</name>
        <name evidence="7" type="ORF">GT040_08875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000407">
        <property type="protein sequence ID" value="MYW29390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="369" mass="37803" checksum="77E4702DA6818522" modified="2021-04-07" version="1">MTAEAPGGRSAQLKHTGLRPGWTTGACATAATTAAYTALLTGDFPDPVSITLPRGQTPAFALAVEELGPGRASAGVVKDAGDDPDVTHGALVRATVRRLPPGSGVVFRAGSGVGTVTLPGLPLDVGEPAVNPVPRRLMREHVERVAAEHGEAGDVEVTVSVDHGEEIARSTWNGRLGILGGLSILGTTGVVVPYSCSAWIDSIRRGVDVARAAGLEHVAGCTGSTSEKTVVAEHNLPGIALLDMGDFAGAVLKYVRRHPVPRLTICGGFAKLSKLAAGHLDLHSARSQVDKPFLADLARQGGATEELASRIATANTGLEALRLCEAAGVPLGDLVAARARDEALAVLRGAPVEVDVICIDRAGVVVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAM6</accession>
    <name>A0A7K2ZAM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_08970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000410">
        <property type="protein sequence ID" value="MYW29406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029509492" evidence="2">
        <location>
            <begin position="34"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="39"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="316" mass="33396" checksum="CF67E4DA01024E3E" modified="2021-04-07" version="1">MSRARRTLVALVLLAATACTTGPSLENQGEVTAPPGDSKELTIGSAGFTESDLLAQMYALLLERAGYSADIISVTNREIYEPALESGQIDVVPEYAATFADWLNAKANGADAAPVGSPDLAATMKALRALAAPRGLTVLDPGRAVDQNAFAVAASYAKEHDLKTLSDLGRAKLPVRLAAGDECVQRPYCAPGLKKTYGIDIVAVDPKGVGTTQAKQAVQNGQDQMVLTTTTDATLDQFGLVLLADDKKLQNADYVVPVVNRARAGSAGVRDALGRLNTVLTTADLASMNEQVDSWRRLPEDIARSYLEAKKLIPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAP3</accession>
    <name>A0A7K2ZAP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Betaine/proline/choline family ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_08950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000410">
        <property type="protein sequence ID" value="MYW29403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="387" mass="41848" checksum="302F0699B33272E7" modified="2021-04-07" version="1">MIRFEQVGKVYPDGTTAVDGLSFEVAEGELVTLVGPSGCGKTTTMMMVNRLIEPTSGRILVDDEDIAGIDPVKLRRRIGYVIQQVGLFPHRTVLDNTATVPALVGWKRARARERAAELLDLVGLDPKTYGSRYPSQLSGGQRQRVGVARALAADPPVLLMDEPFGAVDPVVRERLQNEFLALQERVRKTVLMVTHDIEEAVRMGDRIAVYGEGRIEQLDTPAAVLGTPATPYVAQFVGSDRGLKRLSVTAIEAEDLEEPPVARLDEPAPVAAERLREAGARWAVVLNGTGELHGWVSADALRSAGERGTVGALARRMEAWVPVGAPLKQAFSEMLQHDAGWVAVLDGARFLGVLTPAKLHEALRRSVDADAQGVGREEVDFDSVADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAY8</accession>
    <name>A0A7K2ZAY8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">recX</name>
        <name evidence="6" type="ORF">GT040_09450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000429">
        <property type="protein sequence ID" value="MYW29494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="22334" checksum="8C6C055E00DC0A40" modified="2021-04-07" version="1">GAGRRARSGTRSSGSPSSSRAERGEPRDQRDKGEPRDPVEQARNICLRLLTGTPRTRKQLADALRKREIPDEAAEEVLARFEDVGLIDDAAFAGAWVESRHHGRGLARRALVRELRTKGVDSSVIDEAVGRLDADQEEERARELVVRKLRSTRGLDRDKRLRRLAGMLARKGYGEGMALRVVRQALEEEGEDTEGLDEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB43</accession>
    <name>A0A7K2ZB43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000456">
        <property type="protein sequence ID" value="MYW29576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="92"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="24424" checksum="5903E7337272057E" modified="2021-04-07" version="1">MHTGQLLGSGRTADVYELDGSWVLRRYRDRSDTTEELAVMSYVRAFGYPVPRIGPPADGARPTDLVLQRLTGPTMSEALLAGTLGAAEGGVLLARLLRELHAIPPRVSADPQDCILHLDLHPENVMLTDRGPVVIDWSTATEGPPGLDRAMSALTLARVALDPEFPAPEAGARTLLTSLLAELAGDGGTDADDLARARARQRENPFLTAPERGCLDAAVKMVLGCAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB54</accession>
    <name>A0A7K2ZB54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000455">
        <property type="protein sequence ID" value="MYW29569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="57" mass="6164" checksum="D140867AA2C6D9B7" modified="2021-04-07" version="1">MKIAAAQLTSAPADIPANIRRLATLAEQARDQGAELLVLGKRTDTRRTSRADGLHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB84</accession>
    <name>A0A7K2ZB84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3710 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000448">
        <property type="protein sequence ID" value="MYW29525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="27045" checksum="F0C91FE77414FD63" modified="2021-04-07" version="1">MFGRRKKSGSAEDAADEVRETEQVAEEGTDGAAAGARRSNLPPAPRPDGPWDLSEVSQPGEGRVDLGGIFVPGVEGMELRVEVAGDAIVAATVVLRDSAVQLQAFAAPKRQGIWGEVREEIASGITQQGGIIDEVEGPLGWELRAQVPVQLPDGTNGVQLVRFVGVDGPRWFLRGVISGQGAVQPEAAGLLETIFRDTVVVRGEGPMAPRDPIVLKLPNDAQMVPEGVQQEEQEGSKFSGGMGQLQRGPEITEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC47</accession>
    <name>A0A7K2ZC47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF861 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000508">
        <property type="protein sequence ID" value="MYW29845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="1">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="12779" checksum="DE7C111B839A0E57" modified="2021-04-07" version="1">MTTNDQAASSFAVHIPDAELEPEPLDPAQIVSGEPVVTGKVLWESADGKQVRGIWQITPGVVTDTEANELFVVVSGRATVAVEGGATLEIGPGDACVLREGDRTTWTVHETLRKAYHISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC67</accession>
    <name>A0A7K2ZC67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000546">
        <property type="protein sequence ID" value="MYW29950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="90" mass="9484" checksum="B06F9349DFA8DCD1" modified="2021-04-07" version="1" fragment="single">MSGFTHLHTVSGFSLRYGASHPERLAERAAERGMRALALTDRDTLAGAVRFAKACRDGGVEVRPVFGADLAVASYAEGAGRAAVRPRTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCJ0</accession>
    <name>A0A7K2ZCJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DJ-1/PfpI/YhbO family deglycase/protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000551">
        <property type="protein sequence ID" value="MYW29985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="21146" checksum="2ACF74F805FB358B" modified="2021-04-07" version="1">MPEPEKILIVTGDAAESLEVLYPYQRLLEEGYEVHIAAPERKTLRFVVHDFEPGYDTYTEKPGYTFPADLAFSEVDPGAYVALVIPGGRAPEYLRNNAELRKIIGAFFSADRPVAQICHGPLITAATGNLSGRRVTAYPALEPDMQSAGATFQDTEAVVDGPLISSRAWPDHPAWMREFLKVLRTRSNLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCK6</accession>
    <name>A0A7K2ZCK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxyurea phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000562">
        <property type="protein sequence ID" value="MYW30038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="104" mass="10958" checksum="94836BA47ECBAB2D" modified="2021-04-07" version="1" fragment="single">MVRLTHAPRIQGVIDIPDELIATQYAYNGAAGRAFVAALPGLAGRFLEEWGLRRDGAAMYGMCALVLPVVREADGVPAALKLQLVDEETVGEPVALRAWGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCN3</accession>
    <name>A0A7K2ZCN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000590">
        <property type="protein sequence ID" value="MYW30082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="10072" checksum="791EC0CB18D9759C" modified="2021-04-07" version="1" fragment="single">GALLARLLGEHGIEAAGVPVTGSTRINVTLVEPDGTLTKINATGPELSVAEAEDVLEAVRSRSASADWIACCGSLPRGLPPQWYAELVARSHRAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCP1</accession>
    <name>A0A7K2ZCP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="2">
        <location>
            <begin position="74"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="37715" checksum="E90E1191F909D1FB" modified="2021-04-07" version="1">MPHGRQTAPHHHPQRSRPAHQPRHQPLHPLQTRHRTRTPGVTRRAAHGTPAQDHGVEYPVKPALAQAVPVIPDGPGWWYEPKADGHRTILRRTEDTVILYARSGRVVTAHWMDLAVAGMGLPPGTTLDGEAVIWKDGRIDFGAAQSRAASSITRARALAAQHPASYLVWDILEHPVRGQVPSLPYTQRRQLLLDLLHDIPPPIQAVPATDDRAVAVAWYEGLQQQGIEGIVAKKGTAPYPLGRRAWLKVRHADTEDALVVGYLGPRRRPQRLALAVGDEGAPIRLSARLDPVLAGRIAEALTAAEVLGERRAEGETYTRVESDLTVEVLAGSGRHGTLSVTRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCV1</accession>
    <name>A0A7K2ZCV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000606">
        <property type="protein sequence ID" value="MYW30184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="35832" checksum="A176FC65E3994A96" modified="2021-04-07" version="1">MKIAFVGKGGSGKTTLSSLFIRHLAANEAHVVAVDADINQHLGAALGLDEAEAAALPAMGAHLPLIKDYLRGTNPRIASAETMIKTTPPGEGSRLLRVCEDNPVFDACARTVRLDDGDIRLMATGPFTESDLGVACYHSKVGAVELCLNHLVDGPDEYVVVDMTAGSDSFASGMFTRFDMTFLVAEPTRKGVSVYRQYKEYARDFGVALKVVGNKVQGPDDLDFLRAEVGDDLLVGVGQSDWVRSMEKGRPSRFELLEADNRMALQALQDAAEDSYGLRDWERYTRQMVHFHLKNAESWGNEKTGADLAAQVDPSFVLGERRAGAGVPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD27</accession>
    <name>A0A7K2ZD27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_13400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000623">
        <property type="protein sequence ID" value="MYW30256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="38"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="178"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="336" mass="35031" checksum="A04952C8B6697FDF" modified="2021-04-07" version="1">MSAPYQQPAAPPAASVPPLAPAPTTRRPAVDWRIRFAALSLIWGFSFLLIKVGTQGFAPFQVTLGRLLAGTAVLAVAMAMRRERLPRPALTWGHITVAAFFLNALPFSLFSYAELTIPSTLAGICNATSPLWGMALSVVALSEDRPTRRRVAGLGVGFLGVLTVLGAWQGFSGLDLPGTGMALLASFSYAVGWIYVRRTLAGTGSSTLTLTGSQLFVGTLQLAVVTPVFTSAPNTFPLLPTLSVLALGALGTGLAVLLQYGLVQEVGPTTGQMVTYFIPVIATAAGVALLGEQLTWNTPVGAVIVLAGAALTQSRPSAAAVRTRTAGSRTKRLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD97</accession>
    <name>A0A7K2ZD97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgl</name>
        <name evidence="9" type="ORF">GT040_13800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="WWKE01000654">
        <property type="protein sequence ID" value="MYW30333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073880142.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000654.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="11"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="27009" checksum="AB40A1C4A04AF1C5" modified="2021-04-07" version="1">MTPPQLVVHRDKELMAQAAAARLITRIVDAQAARGHASVVLTGGRNGNGLLAALAAAPARDAVDWARLDLWWGDERFLPEGDPERNVTQAREALLDAVPLDPARVHAMPASDGPYGKDVDEAAAGYAAELAAAAGPEDHGRVPAFDVLMLGVGPDTHVASLFPELPAVRETERTVVGVHGAPKPPPVRVSLTLPAIRAAREVWLLAAGEDKAEAAAIALSGAGEIQAPAAGAYGRSRTLWLLDAAAASQLPRALYPPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDA8</accession>
    <name>A0A7K2ZDA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000655">
        <property type="protein sequence ID" value="MYW30341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="76" mass="8415" checksum="77480258CCF756BA" modified="2021-04-07" version="1">MGAGAAPDDEAARRLGAELRALQQRSGRTLRDQETRVRISDSSLSRYFRGTTVPPWATVRDLRRALGADPTAYRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDB4</accession>
    <name>A0A7K2ZDB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heme A synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_13765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000654">
        <property type="protein sequence ID" value="MYW30326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="35200" checksum="74AF0C34AA25F073" modified="2021-04-07" version="1">MVRVETPITAIAKRWTPSTKVVKRAALSAVVMSVFIIVTGGAVRLTGSGLGCDTWPKCTDDSLFATPAQGMHGAIEFGNRLLTYVLSAAVGWAIIAVSSMKPRRRKVTRLAWSQFWIVLGNAILGGITVWAGLNPWTVAGHFLLANLLLAVAVITWVRIGEGDGPPRPRAPLPVRRLSWAILATTVVLIVLGTSVTGSGKHAGDSSDVPRMPWDWSAAAHVHAIAAWVVCALAIAMWLALRVVDAPADTRARARDLLVVLLAQGAIGYVQYFSDVPEILVGIHMFGSAIMWIAVVRLVLSMRERGDEEPATLPRPSASAERRESAQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDH9</accession>
    <name>A0A7K2ZDH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkene reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="372" mass="39396" checksum="21A7A89A72CD35BC" modified="2021-04-07" version="1">MTLIDTHSDTHPETHPDTLFTGYRLGDLTLPNRVVMAPMSRVRAAAGGLATPSMATYYAQRATAGLIVSEGVQPSLIGQSNPGTPGLHTDEQVASWRPVTAAVHANGGRIFAQIMHGGRVSHPDTNGLVPVGPSAVPAVGEVFTPSGPQPAPMPRALETAEVPEHARSYAAAARRAVDAGFDGVELHGANGYLISQFLSSNANLRTDRYGGSVANRVRFAVEAVEATIDAVGAARTGIRLSPGGTFWGVEEKDVPELYAVLLGELARLEPAYVHLEATAEDEILVALRRAWPGALIMNPVLPMGARRAERPDADRWLGLGADLISFGRAFIANPDLVERLRAGLPLAAEDAETYFQGGDAGYVTYPAYQHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDM2</accession>
    <name>A0A7K2ZDM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_14460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000672">
        <property type="protein sequence ID" value="MYW30451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="118"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="223"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="392" mass="42587" checksum="F81C97FAFC7F9071" modified="2021-04-07" version="1">MHLAPTERQQQLRTELRAYFAAVLPERGSWRDDPGEQRRLLRRIGTDGMLGLGWPVAYGGQGRGPDEQFVFFDEAYRAGAPVSMVTLNTVGPTLMKYGTEEQKAYFLPRILSGDLVFAIGYSEPEAGTDLAALRTRAVRDGDDWVVQGQKIFTSNAQQADWIWLACRTDPDAPKHRGISIILVPTDDPGFSWTPIETVGGLTTTATYYDGVRVPASNLVGEENQGWGLITNQLNHERVALAALGMQAEDFYEEALAHARTPDPATGRRRIDEPWVRARLAEAYARLAATRLLNWRLVGAVGAGALAPGEASGVKFAGTESAVEVYRMCQEVVGDVGLLRGGSAGCFGAEGSAGGELERMNRAAQINTFGGGVSEVQREIVATMRLGMTRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE00</accession>
    <name>A0A7K2ZE00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000696">
        <property type="protein sequence ID" value="MYW30505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="143" mass="14804" checksum="6E321F734146A561" modified="2021-04-07" version="1" fragment="single">MADTPDGRKPAAGAPDVVVRAERLSFGYPGREVLRGIDLSIGAGELVALIGLNGCGKSTFLKLAAGLLTPSDGRVLLDGDDAARLPRRAAARRVALLHQSAPAVPALTVRQLVRQGRYATRGPLGMLRDGDDGVTARALADVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE53</accession>
    <name>A0A7K2ZE53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ohr family peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000722">
        <property type="protein sequence ID" value="MYW30631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="14329" checksum="DDBA32A889EE778C" modified="2021-04-07" version="1">MTIQKIDVAYTAVATAENGRDGRVSSDDGQLDVVVNPPKAMGGSGAGTNPEQLFAAGYSACFQGALGVVARQEKADISGSTVTASVSIGKTEAGGFGLEVAISATIPNVDAATAQSLIEKAHQVCPYSNATRGNIKVELSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE76</accession>
    <name>A0A7K2ZE76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000722">
        <property type="protein sequence ID" value="MYW30632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="339" mass="35939" checksum="7C851585C2842DCD" modified="2021-04-07" version="1">MSAALPTSSREWHLVARPHGWPKAEDFALREVAVAAPAEGRILVRNKFFSVDPYMRGRMNDVKSYTPPFKLDHPMDGGAVGEVIASNAEGFAVGDHVLHGLGWREIADVPAKHAVKVDPGLAPLSAYLGVLGMTGLTAYAGLFDVASFKEGDAVFVSGAAGAVGSQVGQLAKLKGASRVIGSAGSDEKVKLLTEEYGFDAAFNYKNGPVRDQLKEAAPDGIDVYFDNVGGDHLEAAIGALNVHGRATICGMIAQYNATEPTPGPRNMALIIGKRLRLQGMLVGDHADLQPKFVEEVAGWLASGELKYRETTVEGIGHGYDAFVGLLRGENTGKMIVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEA4</accession>
    <name>A0A7K2ZEA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3327 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000720">
        <property type="protein sequence ID" value="MYW30615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008849">
        <property type="term" value="F:enterochelin esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021764">
        <property type="entry name" value="Enterochelin_esterase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11806">
        <property type="entry name" value="DUF3327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3327" evidence="1">
        <location>
            <begin position="66"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="188" mass="20521" checksum="2C81CD46FCBCC249" modified="2021-04-07" version="1" fragment="single">MSDCTDVDAAPRPVTGPRIARLARQLEAAGTAEARDALAETFWAEAARTGTPLVEELDDAPGHRAVTFLWRGHRATRRVLLMAPGITDPERLADSLLHHLPGTDIWYLGHRLRADHRGSYRMVADISAGPAPADPALLQRRLLALRAHGGADPLNPARIPVRWRDAQDSVFALPDAPPQPWAARRPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEJ1</accession>
    <name>A0A7K2ZEJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glnA</name>
        <name evidence="6" type="ORF">GT040_16160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000758">
        <property type="protein sequence ID" value="MYW30770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003969536.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6210091"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="104"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="453" mass="50390" checksum="D80B3DA149BA258D" modified="2021-04-07" version="1">MDKQQEFVLRTLEERDIRFVRLWFTDVLGFLKSVAVAPAELEQAFDEGIGFDGSAIEGFARVYESDMIAKPDPGTFQILPWRAEAPGTARMFCDILMPDGSPSFADPRYVLKRILAKTSDLGFTFYTHPEIEFFLLKNKPVDGTRPTPADSSGYFDHTPQNVGMDFRRQAITMLESMGISVEFSHHEGAPGQQEIDLRYADALSTADNIMTFRLVMKQVALEQGVQATFMPKPFSEYPGSGMHTHLSLFEGDRNAFYESGAEYQLSKVGRSFIAGLLTHAAEISAVTNQWVNSYKRIWGGSSRAAGAGGEAPSYICWGHNNRSALIRVPMYKPGKTGSARVEVRSIDSGANPYLTYAVLLAAGLKGIEEGYELPAGADDDVWALSDAERRAMGIEPLPQNLGEAISLMEKSELVAETLGEHVFDFFLRNKKQEWEEYRSEVTAFELKNLLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEP3</accession>
    <name>A0A7K2ZEP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">GT040_16365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000763">
        <property type="protein sequence ID" value="MYW30806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="15"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="427" mass="44683" checksum="EEFDA4048C3E05D8" modified="2021-04-07" version="1">MTTLSPYDNLSPVAQTAYRARAAAADIAPLPRAAKDDALLAIADALEVRTAEIVEANAQDVEKAREAGTSEGIIDRLTLTPERIRAIAADVRDVAALPDPVGEVVRGSTLPNGIDLRQVRVPLGVVGIIYEARPNVTVDAAALCLKSGNAVLLRGSSSAYGSNTALVRVLRDAVGGSGLPADAVQLVPGESRESVRELMRARGLVDVLIPRGGASLIRTVVEESTVPVIETGTGNCHVYVDAETDLTMAVDILINSKAQRPSVCNSAETLLVHKDVADAFLPLALDALAEAGVTVHGDEQVLARAEGTKATVVAAATEDWETEYLSYDIAAAVVDSLDAAVAHIRLWSSGHTEAIVTTSQAAARRFTQLVDSTTVAVNASTRFTDGGQFGFGAEIGISTQKLHARGPMGLPELTSTKYIVTGDGHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF85</accession>
    <name>A0A7K2ZF85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_17470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000816">
        <property type="protein sequence ID" value="MYW31020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076968365.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000816.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="82"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="314" mass="33729" checksum="6942F1791AECDAF0" modified="2021-04-07" version="1">MLFTKDLKGRTSHADKGCVSTLAHTMMTAARSADSGLAGPGELDRYPYTEAPAGERAAARPWGGSDSELGRASRRGAASRGRGLHGQLVQQLGQMIVSGDLGADRPLVPEEIGQRFEVSRTVVRESLRVLEAKGLVSARPNVGTRVRPVSDWNLLDPDIIEWRAFGPQRDDQRRELAELRWTIEPLAARLAAGHGREDLQQRLGDMVEIMGHAMGQGDAITFSRADAEFHALLIQAAGNRMLEHLSGIVSAALHVSGGPVTGCDRPGEASLAHHARIVDALASGDSAGAETAMRQLLVVHPDVERVVPAPREQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFI2</accession>
    <name>A0A7K2ZFI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cardiolipin synthase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000846">
        <property type="protein sequence ID" value="MYW31090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="392" mass="44730" checksum="2EFD1438A4309CED" modified="2021-04-07" version="1">MELDPDVCEKRSLRLRRRLERLIGIAATEGNSLLPLRNGDQIFGAMLKAIREAEHTVDMMTFVYWRGDIAKDFAEALAERARAGVRVRLLLDGFGSRLIEKDQLDMMDEAGVTVAWFRKPLYLSPLKQNHRCHRKVLITDESTAFTGGVGIAEEWCGDARNEHEWRDTHVQVRGPAVDGLAAAFAQNWAECQDELFDERDRFVASDPHGDAVVQVIRGSSSFGWQDMQTLMRVVLESAEERIRLTTAYFAPDDYFTGLLCAAARRGVEVEILLPGPHTDKRVCQLAGQRYYEELTACGVKIYQYQPTMMHAKVLTIDRVASLIGSTNFNRRSLDHDEEVMLAVMDREFTDALDAHFDEDRAKSVLIERGRWKRRDVLQRAREAAVVPIRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFQ3</accession>
    <name>A0A7K2ZFQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin acylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_18415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="3">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000862">
        <property type="protein sequence ID" value="MYW31193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="915" mass="100373" checksum="629C3F136B7EE87A" modified="2021-04-07" version="1">MPANTTDSSGPSDDAKKPGKKKGRRVRLLLLVLVLALVAGVGFGAYWSVSTVRASYPQTTGTITLDGLSGDVEVKRDSYGIPQIYADSDADLFRAQGFVQAQDRFWEMDVRRHLTAGRLSEMFGSGQVETDSFLRTLGWRKVAQEEYDKVLDEDTKKNLQSYADGVNAYLKGKEGRDISVEYAALGLTNDYKPGEWTPVDSVAWLKAMAWDLRGNMQDEIDRSLLTSRLDGGQIKDLYPDYPYGTHKPIVDRGAISPVTGKYDLDAAPSSGIGSQTAQGATEGLNTQLSALSDTLDKIPALLGPNGNGIGSNSWVVGGAHTTTGKALLANDPHLAPMLPSLWYQMGLHCRQLSKTCQYDTAGYTFSGMPGVIIGHNQDIAWGLTNLGADVTDLFLEKVSGDGYLYDNAVKPFTTREETIKVAGGRDRKITVRETNNGPLVSDRSKELDKVGQKAPVPNAAPDRADGYAVALKWTALKPGKSMDAVFAINRAKDFTTFRAAARNFEVPSQNLIYADTQGNIGYQAPGTIPVRLKGDGTLPSPGWDPAYGWAKEPIPFDELPYEYNPKRGYIVTANQAVIDESKYPHLLTKDWGYGARSQRINDLLASKIKGGEKVSTDDMQKLQMDNTSEIAALLVPELLKINISDPSVREAQKLLEGWDYTQESDSAAAAYFNGVWRNILKLAFGNKLPKELRVKGDCINVPPAKNSGPADQQKKLVRECGQRDGDTAQPDGGDRWFQVVRDIVEDQDNEWWKAPARGREDALEGRDDVFAQAMHDARWELTSKLGKDISTWSWGRLHRLMLKNQTLGTEGPDLLQRALNRGPWNLGGGEATVNATGWNAASGYEVVWVPSMRMVVNVGDWDKSRWINLTGASGHAFSAHYTDQTDKWSNGELLDWSFGTDAVDASTVDTLTLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG67</accession>
    <name>A0A7K2ZG67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lysoplasmalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_19230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000905">
        <property type="protein sequence ID" value="MYW31347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="23320" checksum="FEA7C2995EB7F12B" modified="2021-04-07" version="1">MSATASRPAPSGTAGAGRFARPLLGAFLVAAAVDLTGLLAGLDTVHLVAKPLLMPLLAAYAAVRGGPRPLIAALLFGWGGDVFLLADNDLAFLLGMGSFAVGHVCYLTLFGRGQARTRASLAAGIAYAVVLAVFLVLIWSDLPAELRVPVAGYSLLLTAMAWRAGVLGRYAAAGGALFLLSDALIATGIAEWPRLPAPDFWVMLTYIAAQLLLALGVLRVGRGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGP0</accession>
    <name>A0A7K2ZGP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000922">
        <property type="protein sequence ID" value="MYW31449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6689" checksum="8B28F4D294C1CFAA" modified="2021-04-07" version="1">WAEVFREGDWAALLELVRKAGPQGLIDRVRELEGADAAAGRVRLRRSKTHDDATAVFVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGS8</accession>
    <name>A0A7K2ZGS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_20115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000937">
        <property type="protein sequence ID" value="MYW31518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="633" mass="68752" checksum="06911F68FA8D1583" modified="2021-04-07" version="1" fragment="single">PRWWEPVGGGAVRWVQRSEVPADARFFGLGGRASGPRLRDGAYGLWNTDPGGRFGPGDDPLYLTMPVQVVVSDAGTHLAFHDNTWAGRVVVREGEEGAGSGHDRPGTCEVRMEGGPLRCWVVTGTPARVLRGWTALTGAPAVPPSWALGPQHARWGFGSEREVRRVVAGYRERGLPLSVLHLDIDHYDGHRVFTVDRERFPALPELAKALRDEGVRLVSIVDPAVKAAPGDAVFDAGVELGERGAYVRDARGRVVVGEVWPGACVYPDFTDPVVREWWGSLYAERLAQGFSGVWHDMNEPVSFAAFGDPSLPRSARHVLEGAGGDHREAHNVYGLAMARAGYEGLLRLRPEERPFLFSRSGWAGMQRYGGTCSGDVSTGWPGLRASLSLVLGLGLCGVPYSGPDVGGFDGFPSPDLYLRWFQLGAYLPLFRTHAAIDAGRREPWEFGPEVLEHARAALLERERLHPYFVTLSHVARLSGAPYVRPVWWAAPGDRALRECEDAFLLGDALLVAPVMEAGAERRVVRLPRGRWYDTVTGRAYEGPGPVVVDAPLSRIPVLARAGAVIPVRDADGDLELEVWAPAPGRTGDGLVVRDPGDGWAEAEVERYVSRWEGDRVVVERDGGEGAGAVGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGW7</accession>
    <name>A0A7K2ZGW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyketide synthase I protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000963">
        <property type="protein sequence ID" value="MYW31555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="2">
        <location>
            <begin position="37"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="463" mass="49515" checksum="1F8B9DB52EE962EB" modified="2021-04-07" version="1" fragment="single">MTAAENQLRDYLKRATADARASRKRLREIEERQQEPIAIVGMACRYPGGVRSPEDLWRIVADGVDAVSPFPEHRGWAEDLYDPDPEAVGRSYTRQGGFLHDADLFDPEFFGMSPREALATDPQQRLLLETAWEAFERARIVPDAVRGSRTGVFVGAMYNDYGSRPHLPPQEFEGYLYSGSAGSVASGRLAYTFGLEGPAVTVDTACSSSLVALHLAAQALRRGECDLALAGGVTVLATPMPFVEFSRLRGLSPDGRCKSFAEEADGTGWAEGVGLLLVARLSDALRDGRQILAVVKGSAINQDGASNGLTAPNGPAQERVIRQALADAGITAADVDAVEAHGTGTTLGDPIEARALLATYGKERPEGRPLLLGSLKSNIGHAQAAAGVGGIIKMVHALNHAHLPRTLHAENPTSHIDWDTGTLELLTEPRDWPETDHPRRAAVSSFGISGTNAHVILEQAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH61</accession>
    <name>A0A7K2ZH61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000986">
        <property type="protein sequence ID" value="MYW31691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029800532" evidence="1">
        <location>
            <begin position="32"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="664" mass="69950" checksum="A24D9E74F34747A9" modified="2021-04-07" version="1">MRTRRISTATAFAVLFSSVVLVGGTAGTAAADSSRILPATSLGDIVADGVHQRVFISDPQSGQILATDYSGKVVRVLGELPGVTGLELSADSGTLYAGVAASDHIVAIDTATLTESARYDIGLGTRPTHPALAGGKLWFGYGAATEGNIGSLDLSGEEPVVTLDQEPDRTWYSAPLLASSPGAPDQLAAAQEGLSPSELAVYDVASGTAERTANLRADASNLHDIAVSPDGAQLVVASGAPYFHQVYRTSDLRAEQGYTSKHYPNAVDIAPNGTVAAGIDGAYDPDIYIYPKGASKTVPVRTYELPNTGATSGSDGLEPAGLAWAPDGSRLFAVSVNSHGTRSFRVLTDPTRSVATLSISAPAKATRAKALTVKGSVKASVALPAGTPVTVTRTDVESPKGKALGTVKTDTKGAFTFKDTPPAGGKVTYKATYAGSAKHTAASASASVTVSRAAVSLKLNRNKAVYAYNKNVSFTATLGKTYKNRVVELWADPFGADKPKKLVKKAKVNSKGNLSVTVNMKRDTTVTAVFAGDSRYAPKTVKSTAYAKVNASLKLSKHYRTAKIGKTSYAYYSKKKNPDFTTNMTYHKDRKHLLTLQLNYQGTWYDAGQQYFALGTSGKSIVTLEGPHETGYKMRVRTSYVNGSSGDSVNSTTHSAWKYFIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH81</accession>
    <name>A0A7K2ZH81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide synthase I protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000998">
        <property type="protein sequence ID" value="MYW31710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="24439" checksum="04BC816E55B94AA1" modified="2021-04-07" version="1" fragment="single">PGATAVRARFGTAAEGAFSLRLTDQDGRPVASVESVLRRAPRPAELVGGPGPLRALHHVTWTPSGLRAPAGPVAWAVLGTGGDAAQDVTRYEDLASVGQAVGAGTSVPLLLTRLHPDEETDTLAALHEETAAALSLLQGWLADERLADTRLVIVAQGSVHATEGDRLRPGAAAVRGLVHSAQSENPGRIVFVDADTEEVAPELLSALLASDEPQAAVRDGRLLLPRLARVPAPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHI0</accession>
    <name>A0A7K2ZHI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001020">
        <property type="protein sequence ID" value="MYW31812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029472493" evidence="2">
        <location>
            <begin position="48"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="207" mass="21851" checksum="55D0071174600DD1" modified="2021-04-07" version="1" fragment="single">MAAHRKSAHRKPKQRPFTGPAARTAATLALAGAATATSATGAGAAPAEPAPTAAQVRAKVDRLYHDAEVATEKYNGAKEKEAAATKAVDALADEAARRTDRLNTARHTLGSMATAQYRTGALDPAVQLALSSDPDSYLERAAHLDRAGDRQASLLSSIRRQLSGIARVKARADQETEALAARRAELDKHRTAIRTKLADARSLLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIH5</accession>
    <name>A0A7K2ZIH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001108">
        <property type="protein sequence ID" value="MYW32152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="21475" checksum="08A0D6469A585A9F" modified="2021-04-07" version="1">MGSALIGLAAAVVGVTGTLIASVLSQRLLGRVQSEQFERQQQVAATQWHREQQVAELNRRRDAYMQVNASLRRYRTHLLNFLWTVHKEAVTPEARELVEEARRDHHSVFAEAQLIASAAVLAQLDGMTADLSEVYRRIMCLEEGSPDPDGSFDDIRDDFVRLWGRWETMRSVMRTDLGVGRSVGEQPAIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIL6</accession>
    <name>A0A7K2ZIL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="11017" checksum="A9D9C688CF72EAC7" modified="2021-04-07" version="1">MHLEFYEVDVPIHTNDRALHGVHVFTGKASSVTEALTRAHQVYDAAFAAQQAGLEVPGRQDGGWGARGVRDGWELDWSAATAGRWFDPYSWTGEKPYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIW1</accession>
    <name>A0A7K2ZIW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001128">
        <property type="protein sequence ID" value="MYW32281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="202"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="358" mass="38150" checksum="6625CADF4D951A5B" modified="2021-04-07" version="1" fragment="single">MTRTEYPWLLPSAMADAELPGDRARARRTVRDWIVDITAFLIAAAIALIALAAIENDGSTPDALLVVDSVIGAAACCALWVRRRWPVGLAAALTVLSIVEPVAGGAMMVALFSLAVHRPFKPAAIVGAGALIVAPLQPWLRPDPETGYLTSLIFGVLLILLVLSWGMVVRSRRQLVLTLRERARRAEAEAELRAQQAQRLAREAIAREMHDVLAHRLTLLSVHAGALEFRPDAPTAEIARAAGVIRDSAHEALQDLREIIGVLRGPGDTGEGERPQPTLATLDGLIEESRRAGMKVAVDQRVAAPEDAPAATGRTVYRIAQECLTNARKHAPGAEVTVTVTGGPGDGLTIEVANPAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJG5</accession>
    <name>A0A7K2ZJG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="336" mass="36635" checksum="40FFF62225423401" modified="2021-04-07" version="1">MRYRYLGKTGLRVSELCLGAMTFGREADERTSHALLDRFTEAGGTFVDTADIYSAGASEEILGRWLKGQRRDDVVVATKVRYGTGEGPNDRGLGRNHLIAGVEASLRRLGTDHIDLYQVHAWDPGTPLEETLATLDALVTSGKVRYIGASNFSGWQLQKAVDLSRAHGWEPFTALQPLYNLLDRSAEWELMEVSRNEGLGVIPWSPLRGGWLSGAIRRGTTAPPSGTRVETAERLGWGESWSAYEGDARTWRVLDALHEVSGRTGLAVPVLALAWLLGRPGVTAPIVGARTLEQLETNLGAADLDLDPADAELLTEASGQALPYPYSVIETDPELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJN1</accession>
    <name>A0A7K2ZJN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001198">
        <property type="protein sequence ID" value="MYW32557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="12101" checksum="F0D8839E567E9BCF" modified="2021-04-07" version="1">MPAGSNAKRERQYEHIKESQEERGSSEKRAKEIAARTVNKERARSGESRTASRTSTKDKKSAYERGGERSHQGAQGPTKDQLYAEAKKKNIEGRSSMNKAELRKALGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKB0</accession>
    <name>A0A7K2ZKB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan DD-metalloendopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_26790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001251">
        <property type="protein sequence ID" value="MYW32781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029513864" evidence="2">
        <location>
            <begin position="40"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="125"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="24034" checksum="BB4E5A3AA9898F13" modified="2021-04-07" version="1">MKRATNQHTIRPSASRIRGAVLAAGLGASVVLGAGSAFAAGNADAAAAPLAAGTTAQSVAQQATAQSKAAETAKKTAAQKAADAKKKAEDKKKAAKKNAASWKTPVKKYTLSASYGTGGARWAAKHSGQDFAVPIGTPVTAAHTGTVVKAGPNGAGDGPAYGNAIVIKHSNGKYSQYAHLSKVNVKLGEKVKTGEKIALSGNTGNSSGPHLHFEIRTSPNYGSALNPAAFLRSVHVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKF9</accession>
    <name>A0A7K2ZKF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-diaminopropionate biosynthesis protein SbnB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sbnB</name>
        <name evidence="1" type="ORF">GT040_26975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001256">
        <property type="protein sequence ID" value="MYW32818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023866">
        <property type="entry name" value="SbnB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03944">
        <property type="entry name" value="dehyd_SbnB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="35856" checksum="79A38D498F8F61F7" modified="2021-04-07" version="1">MLTIGNGDVRRLLDDREREVLNAVREAYLLHAAEDTSLPHSVFLRFPDDPGNRIIGLPAYLGGAEPLAGMKWIASFPGNVAEGLERASAAIIVNSMRTGRPVALVEGSTISARRTAASAALAAVSLPSEDGRETGVSLIGCGVINFEVLRFLLVVRPEITDITVHDLDARRAADFRDRCSAELAGDGRVVRVAESAGAALSAHRLVSLATTATVPHLDLDECLPGTLVLHVSLRDVTVEGVLDAVNVVDDPDHVCRAATSVHLAETRVGGRSFIGATLGELLRDAEPGPRDPARTTLFSPFGLGVLDLALAGLVVREARAAGVGHEISGFLPEPRTAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL20</accession>
    <name>A0A7K2ZL20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein DivIVA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001306">
        <property type="protein sequence ID" value="MYW33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="7442" checksum="E5DDB63866F88DC3" modified="2021-04-07" version="1">YRMADVDEALSRLGAELAERDARIAELESALAGAQASAVTTGTDLFKQPGDRPTGPGDRQTGGPARGEEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLB9</accession>
    <name>A0A7K2ZLB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001337">
        <property type="protein sequence ID" value="MYW33142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12485" checksum="AFAFB5E5005EB5F5" modified="2021-04-07" version="1" fragment="single">LPREQAAALLNLADLDARTGRPRDALTRYRAALDAGRAAGDLYATGRAMESVGSTYAELGDYHRASDWYGRALAQRLTQGERADEARLYGRLGAVHSYAGRYGEALRNWRAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLC6</accession>
    <name>A0A7K2ZLC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_28770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001345">
        <property type="protein sequence ID" value="MYW33157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="32776" checksum="6C918A1F7368FF9C" modified="2021-04-07" version="1">MASTDITSDRKRADGTAGPVDAKPDDLAGLEAGLDALDAVQIRRTPVREVLRSKVLPPVVAVALVLIVWELLVRAEVTEVYKLPPPSAVWDSAKDMWLKGTLLEVVWTSVSRGLLGFLLAVAIGTPLGLLVARVKLIRAAIGPILSGLQSLPSVAWVAPAVIWLGLNDSMMYAVILLGAVPSIANGLVSGVDQVPPLFLRAGRTLGATGIRGTWHIVLPAALPGYLAGLKQGWAFSWRSLMAAEIIASSPELGLGLGQLLENGRSNFDMPGVFLSILLILFVGIAIDLLIFSPLERWVLRSRGLLVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLE4</accession>
    <name>A0A7K2ZLE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SulP family inorganic anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_28300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="14"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="207" mass="20797" checksum="75A4EC3F7DE59B09" modified="2021-04-07" version="1" fragment="single">MISVKELKNPHVVRRDLLASLVVFLVALPLCVGVAVASGVPAELGLVTGIVGGLVVGMLPGSKLQVSGPAAGLTVLVYEAVTEFGLATLGPIVLAAGLVQVVLGVARFGRWFRAISVSVVQGMLAGIGLVIVLGQLYAMADTEQPGTALAKLAGLPGLAAEIVTDNEAMTAFGLGAGTVAVLLIWPKLPARVRLVPAPLAAVGLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLG4</accession>
    <name>A0A7K2ZLG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_28775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001345">
        <property type="protein sequence ID" value="MYW33158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514603.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001345.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="263" mass="28984" checksum="9FAD0DE87198AA1A" modified="2021-04-07" version="1">MATTTLTKAEDRTTVEHAARLAHVSKSFAGPTGQQLVLDDITLDVAPGEFVTLLGASGCGKSTLLNLVAGLDRPSAGSIETPGGRPALMFQEHALFPWLTAGKNIELALRLRGVPKSERRTEAERLLELVRLGGAYGKRVHELSGGMRQRVAMARALAQDSQLLLMDEPFAALDAITRDVLHDELTRIWRETNASVLFVTHNVREAVRLAQRVVLLSSRPGRIAREWTVDIEQPRRIEDTAVAELSVEITEELRGEIRRHGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLI2</accession>
    <name>A0A7K2ZLI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001349">
        <property type="protein sequence ID" value="MYW33178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="494" mass="53331" checksum="9DD09B490FCC9707" modified="2021-04-07" version="1">MTVTEDSPELAPGIDEFGPGIDPERLAVCLSVLDELDRIEVDHPDAIAVRRATAGIYRTVKQRRRQERRAAKTAHDRAVTEATATGSAERIDDETQGVLPSSSAQAEIAGILQRPRSCYICKTRYVEVDAFYHQLCQPCAKENRARRDARTDLSGRRALLTGGRAKIGMYIALRLLRDGAHTTITTRFPNDAIRRFKAMEDSDEWIHRLKIVGIDLRDPAQVVALADSVAAEGPLDILINNAAQTVRRSPGAYSELVNAESAPLPAGALPAAEVIGTFGSGTVDRVAALPAARKEGLSAQEVTDLALVTGSASPARIAAGTAIDAGGLVPDLHDTNSWVQTVEDVEPIELLEVQLCNSTAPFILISRLRPAMAATAAQHAYVVNVSAMEGVFGRGYKGAGHPHTNMAKAALNMLTRTSAQEMFEKDNILMTAVDTGWITDERPHPDKMRLAEEGFHAPLDLVDGAARVYDPIVRGEGGEALYGCFLKDYAPANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM00</accession>
    <name>A0A7K2ZM00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001381">
        <property type="protein sequence ID" value="MYW33338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="133" mass="13284" checksum="223734F7D7231021" modified="2021-04-07" version="1">AGAVKGAGGPNDSSVTLHVRAAGGLTLLLLGDLEPPAQRGLLHSPAGFLRVDVLKVAHHGSGFQDAGLLESARPRLALISCGADNPYGHPAPRTVDALRAAGARVLRTDTDGAIAVTGAGKELRAVGRSGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM17</accession>
    <name>A0A7K2ZM17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001370">
        <property type="protein sequence ID" value="MYW33309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="27659" checksum="B5FA7646691A51BA" modified="2021-04-07" version="1" fragment="single">MAGESPDKTEQRKSSGTAAEERDPRFAVFREAGADVAEDAAADEATPDEATPDGVTTGEVPPDTATAVFRPRLPEDEAGRAPERSASGPEEPASGEEEPAKAPEGAVTPQKPAEGSEDAEASEGADAAAEAPEGVADDTSDAGVGGPEPGDVRLRAAVAAWVDAAAEGEDTADDKADDSADSAKGEVEAEGEPAADADAEPADDSDSDSEAEAESELKSAEKPEPEPAEELEAEAETATATAAGAEKAEPAADADADAESKSDADSTSNDDGEGPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZML7</accession>
    <name>A0A7K2ZML7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11698" checksum="F348BBF19DE0902B" modified="2021-04-07" version="1">MTTPTAWPENVIARYLTVAGSSLNRDDIAVDITCTQTAREKGRHDQEVGDITLVAHCSGCSDRDETTCEGLYLDLVEPVLKSFYGDHSREWAQSHAETCRAIPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMU9</accession>
    <name>A0A7K2ZMU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15640" checksum="2EC5634B94D1933C" modified="2021-04-07" version="1">MLQCTAVTRIPLGEVTVALVTMAGGPGTPPDDFTLDHYVLCELGEHDTLTDHAALLSAADAPDRPALWFFWTGTDTDRAHRIQTEPWCPATLRNLAADTLLRCSFFNDHTTGHSWDVTDPLGDLIAGALSADDTSDDPQERPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMV4</accession>
    <name>A0A7K2ZMV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001442">
        <property type="protein sequence ID" value="MYW33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="33"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="201" mass="21950" checksum="E6D848CDB3037434" modified="2021-04-07" version="1" fragment="single">MERVDRCVVLVDAGYLLGAAASLLAGEPARSRITVDHAALIQGLRERAEADTQQPLLRIYWFDGAPDRVPQPEHRRLRVMPRVTVRLGALTRSDGRWAQKGVDAAMHAELTELARNRACSDVVLVTGDGDLLPGLMSAKEHGVAVHLWAVQAADGDYNQSEDLVAEADERRVLDRAWITKAVRAKDTGGNCPPPPAPRPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNL8</accession>
    <name>A0A7K2ZNL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001500">
        <property type="protein sequence ID" value="MYW33937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="156"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="359" mass="39604" checksum="F29C3171FC1DCA6D" modified="2021-04-07" version="1">MKTYEHGLVLGKFYPPHAGHHHLVRTAQDHCERLTVLVCAASVESVPLADRVAWMREIHPDVTVVGAVDDTHMDVTDPAVWDAHMAVFTAAVPERVDAVFTSEAYGEELGRRFGAASVLVDADRTLFPVSGTAVRKDPVGCWDFLRAPVRAALARRVVVLGAESTGTTTLARALAGHYRARGGVWAGTGYVAEYGREYSEHKLAALRERWPGAAWEDVTFSTGDFPVIAEAQNEREEAAARTGSPVLFCDTDSFATTVWHERYVGGRNPLVEEIADRTAHHLWLLTDHEGVAFEDDGLRDGEELRPWMTDRFRAELTRTGRRFIEITGPPEARLAQAVAAVDELLATGWDFAAPLPEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNM3</accession>
    <name>A0A7K2ZNM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001489">
        <property type="protein sequence ID" value="MYW33878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="75"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="28742" checksum="14F99823170AF5F4" modified="2021-04-07" version="1">MHRSAYEQMELCIQEYLPVEGPGGGPSGGSVSGNGSYRVVDLGSRISGKQTRTHRALLAGHPVDYFGVDVQDGPNVDAVMKKPYRIPARSNSADVVLSGQAFEHIPFFWASMLEIARVLKPGGHAFITAPSRGHVHDAQDCWRYYPDGFRALAAHSRLELREAYTDFPPQKGIWHDYRAIDKKAAYWGDSVGVFRKPQRYPRLTMFAVRELAVWWANRVGGVDAVPLPAPLDGREQCGRPKTVPVPAPSLEQESARSMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNN9</accession>
    <name>A0A7K2ZNN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_33080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001506">
        <property type="protein sequence ID" value="MYW33976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="511"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1044" mass="111843" checksum="986E5A2A41D03EA7" modified="2021-04-07" version="1">MNTSPTDDGSVLELFAARTRARPDAPAVISGTQMLTYAELDARADAVAWLLKDAGVGQDVPVVVRVDRSPNMAVALLGVLKAGGVYVPLDPKYPSERNKFVLEDTGAPVVLTTRELASGPADGRARTVLLDESAPDAARTDSPQAPRPQDLAYVIYTSGSTGRPKGVMVDHTSLTGHLAAITEAFGYREDDRTLVSVSAAFDVSIEQMLAPLVRGATAVIQPDDVVAPKDVIRYVHEHSVTILNMTPVYLDAVIREGTGLETVRLVVSGGDVIRSGIVRAARTSLAGKRVLNVYGPTEATITAMVQELSEVAEGDPVPIGRPVSRTRVHLVGEDGAEVGPGEVGEILIGGDRVARGYLNRPALTEKQFVPDRFGPPGGRLYRTGDLARRLPGGSLEFVGRFDDQVKIRGFRITLGEVESALASLRGVAGAVVVARPDATGEPRLTGYVTRTAEADGTTEPRKALQAVLPAHLVPAAVVELDAFPMTPNGKVDRSALPEPVAVNGSPASATEPANRAEALLAGIWAEVLRVDSVGTHDSFFDLGGHSLLAFQLASRVSAATGKDIPLRLVFEHPTVAGMAAVTGSLQEAVAGASAPTRCEGRTEGPLSAGQERLWIVQSLDPEGYQYNVPSLWHLSGEVDAAALAAAFDALVRRHEILRTWFVAGEDGPRQVVAPADANGFRLTRESVEFSADGIPEQVRAFAEEPFDLSTAPLVRAGLFEDPRRAGEALLLLVFHHIAVDGSSLPTVLRDLEALYRQAAGEPQGGLPDVPLQFLDFAVWAERQSAEEADLHLAYWHERLKDLPALELPADRPRPPYWSGHGASVEFALPTSVALGLRSLGGQENASSFMVLLAAFKVVLARWSGQGDIAVGAATNGRSLPELEQLVGFLTDTVVLRSAVSAERTFRDVLGDVRAATLGAMKHNSVSYGHVVDALRPERRLDRNPVFQVFFSYEAESDLPRWELPRADVTHRDWPMSSSKFDLDLTCVESEGQLRCSVIYATDLFEAATVERFSRDFQSLLRFLVSGGGPDAALAEWQPSPPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNS3</accession>
    <name>A0A7K2ZNS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001524">
        <property type="protein sequence ID" value="MYW34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="21229" checksum="D84EBAA91A13724B" modified="2021-04-07" version="1" fragment="single">MSPRSTPGPAPRPTTGPAARRSAPRARPGPDDLRRTFEAVPARTSQEGEPFADSWWGRAWVAALESLSMDEARLARGRAYADEGKVAAITVTPGRVVAYVLGSRARPYRAELRLRTFTDTGWDTLLDAVAAHPGHLSALLAKEMPHSLADTAREADVRLLPGGDDLDPSCTCPDHGRPCKHVAALSYQTARLLDSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPQ1</accession>
    <name>A0A7K2ZPQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AIM24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_35025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001598">
        <property type="protein sequence ID" value="MYW34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="224" mass="23822" checksum="E5A94962F37DDBBF" modified="2021-04-07" version="1">MKSDLFSSEHMAQPATAPGMTLQNSKSIKYAVNGEMHARQGSMIAFRGNLQFERKGQGIGGMLKRAVTGEGLALMAVRGQGEAWFAHEAANCFILEMDQGDQITINGRNVLCFDATLSYEIKTVKGAGMIGGGLFNSVFTGYGKIGLMCEGTPIVIPVTGAQPVYVDTDAVVGWSQQLTTSLHRSQSVGSMVRGGSGEAVQLMLQGEGFVIVRPSEARPEKTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPZ1</accession>
    <name>A0A7K2ZPZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fluoride efflux transporter CrcB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">crcB</name>
        <name evidence="10" type="ORF">GT040_35500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001624">
        <property type="protein sequence ID" value="MYW34441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="12179" checksum="47201F8AA008E5F8" modified="2021-04-07" version="1" fragment="single">MNWLLVVVGGAVGAPLRYLTDRAVQAHQGRGVAYVFPWGTFTANAAGSLILGVLTGAAVSSPVHALLATGLCGALTTYSTFSYETLRLAETGRAFLAAANVVASLLVGLGAVFLGAELAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ10</accession>
    <name>A0A7K2ZQ10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_35310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001616">
        <property type="protein sequence ID" value="MYW34407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="5">
        <location>
            <begin position="89"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="386" mass="41544" checksum="6078D4EDBCAFAFBE" modified="2021-04-07" version="1" fragment="single">TLRAAAAAAEAGLPLSRHLVRHLATTVRPLPVPWPPEAREELVTLLGAGESTVGVWEALEAEGIITRLLPDWERVHCRPQRNPVHTWTVDRHLVETAARASSLTRRVHRPDLLLVAALFHDIGKGWPGDHSVAGEVIARDMATRIGFDKHDVGVIATLVRHHLLLVDTATRRDLDDPATVRSVAEAVSTASTLELLHALTEADALATGPAAWSTWRASLVADLVKRVAAVLAGEAPEEPEEAAPSAEHERLAIEALRTGEPALTLHTHPEEPAGDGEAEPVGVELLIALPDRPGVLPAAAGVLALHRLTVRAADLRAVELPNEVGERADLLLLSWRVAAEYGSLPQAVRLRADLVRALDGSLDIRARLAEREAAYPRRRGVKAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQT2</accession>
    <name>A0A7K2ZQT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ORF">GT040_37010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="341"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW34731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="466" mass="52006" checksum="6088C8DEEC9D28F6" modified="2021-04-07" version="1">MTIRLHDTSARQIRDFVPLTAGCVSIYLCGATVQAAPHIGHIRSGLNFDIMRRWFTYRGYDVTFIRNVTDIDDKIIKKSAEQGRPWWSIGYENERAFNDGYDALGCLPPTYEPRATGHITEMIEMMRGLIERGHAYEADGNVYFDVRSLPGYLSLSNQELDDLRQPAGEGETGKRDQRDFAMWKAAKPGEPSWETPWGRGRPGWHLECSAMAHKYLGSAFDIHGGGLDLIFPHHENEIAQAKAYGDAFANYWVHNAWVTMAGEKMSKSLGNSVLVSEMVKHWRPIVLRYYLGTPHYRSMIEYSEESLREAESAFARIEGFVQRVTEKAGETVAPAAEVPPAFAEAMDEDLGVPQALAIVHTTVRQGNSALAADDKEAAVARLAEVRAMLGVLGLDPLDEHWAGEGDRGEDLHGVVDTLVRLVLDQRQSARERKDWAAADAIRDQLNQSGLVIEDSANGPRWTLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQV4</accession>
    <name>A0A7K2ZQV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="27"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="336" mass="36202" checksum="4ED806CFB536BBAE" modified="2021-04-07" version="1">MSQQTPAAPLPLILRTLGVADRDLVACTPLTGGTYNTVTRVTLTDGRDWVVKTPPPHSAGLRYERDLLVNEVAFYTAAARAGGPAVPRVVHSEPDPTAPTGAYVVMTARPGRPWHEVDRSEDPHAEPRLRAELGRIVGRLHTVTGPGGFGYPAAPFGPPAATWRTAFTAMTEAVLADAETYRAPLPYPVDRIRTVLARAAPVLDDVIRPALVHFDLWQGNLLVAGEPGARSIGGVIDGERMFWGDPVADFVSLALFGELEEDGDFLAGYAESKGGRLEFGESVRLRLALYRSYLYLIMLVETVPRGVGPEAAEETRQLVAPHLVAALDAVSRRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR51</accession>
    <name>A0A7K2ZR51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001698">
        <property type="protein sequence ID" value="MYW34841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="291" mass="31282" checksum="CA7B4B738EB80660" modified="2021-04-07" version="1">MTLRLGYGTNGLTDLRLDDALGLLADLGYDGVGLTLDHMHLDPLAPDLAERTREVRRRLTSLGLRVTVETGARYVLDPRRKHGPSLLDPDPDARAARTALLVRAVDVAAELGAHAVHCFSGITPPDTSTDTAWKRLTEAITPVLDAADRSGIPLAIEPEPGHLLATLADFHHLRALLGDPAPLGLTLDIGHCQCLEEASPVQCVQDSAPWLRHVQIEDMRRGVHEHLPFGDGEIDFPPVLAALTAADYQGLTVVELPRHSHAGPELARTSIAFLRDAMTKGAINKKGGAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRP5</accession>
    <name>A0A7K2ZRP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001741">
        <property type="protein sequence ID" value="MYW35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="187" mass="20197" checksum="4BEBE8FF05E94593" modified="2021-04-07" version="1">MDDQERRAARREVLLLEYEVLKAEQKARIIARDHLMYATLAGLASVLVVVFTAEAPAGTVLLLPPVCLVLGWTYLANDQKISAAGRYLRDELAPRLADLTGSRPGEVLGWEWAHRGERGRGAAKILQLAVDLVMFVVPTVVAVVLHWTAATPGRGLSLVAVAELAAAAVLAVRIVLAADFASERRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRS4</accession>
    <name>A0A7K2ZRS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001772">
        <property type="protein sequence ID" value="MYW35090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="28"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="26839" checksum="B95D102F47EDE641" modified="2021-04-07" version="1">MSSATAKGSAPVPSTVPPRYDDLRALYLNCTLKPSPETSNTEGVIDRSTAVMRAAGVRTQVIRPVDLDLAVGVQPDMTRHGAATDAWPELYAEVMAADILVLCGPIWLGDNSSVMKHVIERLYSNSADLNDAGQSAYYGRVGGCLITGNEDGLKHCAMNILYSLQHIGYAIPPQADAGWIGEAGPGPSYLDPGSGGPENDFTNRNTTFAAWNLMHLAALLKRSGGVPAYGNQRPEWQAGCRFDAPNPEHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRU4</accession>
    <name>A0A7K2ZRU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_38695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001763">
        <property type="protein sequence ID" value="MYW35052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="27312" checksum="CDDC2F8D2CD71B6E" modified="2021-04-07" version="1">MSLRIVVCVKYVPDATGDRHFADDLTLDREDVDGLLSELDEYAVEQALQIADAADDAEITVVTVGPEDAKDALRKALSMGADKAVHVEDDDLHGTDVMGTSLVLAKAVEKTGFDLVICGMASTDGVMGVLPALLAERLGVPQVTLLSEVAVDGGVVTGRRDGDTASEQLQASLPAVVSVTDQSGEARYPSFKGIMAAKKKPVESLGLDDLELEADEVGLAGAWTAVDSATERPARTAGTIVKDEGEGGKQLAEFLAGQKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRV4</accession>
    <name>A0A7K2ZRV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001769">
        <property type="protein sequence ID" value="MYW35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7118" checksum="68755AFB59803B11" modified="2021-04-07" version="1" fragment="single">EEAVERARRWARRPDALGASAAGILACRGIAQDAPQVLGALREAVRGDGPDAPRLWTLVDGTGRLGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRY1</accession>
    <name>A0A7K2ZRY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001779">
        <property type="protein sequence ID" value="MYW35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="103"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="22005" checksum="1D630632C6CEE643" modified="2021-04-07" version="1">MGIRIQQAGQGDRELVVSVLEEAFHHDPVSSWVFPDEAHRRAVHGRFLGVFADITLAEGRIDVAEDGAAVALWLPVPAGAPEEEDPTPALMRQTADPDNERCELVGRLTGKVHPHDRAHSYLLMIGVSPQRQGEGVGAELIRAELDRCDRDGVPAYLEASSARSRTLYERLGFRFLGRAVELPDGPSMWPMWREPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRY2</accession>
    <name>A0A7K2ZRY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-2-hydroxyacid dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_39030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001775">
        <property type="protein sequence ID" value="MYW35116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="27"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="114"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="319" mass="33876" checksum="F59C5E79623C83C9" modified="2021-04-07" version="1">MKLRCAVIEDFQSAATTVADWSPVTADVDIVTFTDHLGSTEEVAAALAEFDIVVTLRERVTFPAEVFARLPRLRLLIASGMRNSVIDFAAAEEHGVTVCGTASSSAPPVELTWALLLGLARSIVPEANGLRGDGPWQSTLGADLHGRTLGLLGLGKIGGRVAQVGRAFGMEVVAWSQNLTEERTKEVGTALAASREELLEAADFVSVHLALSERTRGLIGAAELARMRPTAYLVNTSRAAIVDQDALLAALRAGTIAGAGIDVFDTEPLPAGHPMRTAPRLLATPHLGYVSHANYATYYGQAVENIRAFLDGEPVRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRZ5</accession>
    <name>A0A7K2ZRZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001780">
        <property type="protein sequence ID" value="MYW35150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="27586" checksum="90665F49D42A164C" modified="2021-04-07" version="1">MTAPGADQPQPLPLSVDRTSPVPLYFQLAQQLEAAVEQGRLAPGTLLGNEIELAARLGLSRPTVRQAIQSLVDKGLMVRRRGVGTQVVHSQVRRPLELSSLYEDLEAAGQRPATKVLRTTMEPATAGIAAALGVAEGTEVRLVERLRYAHDEPMALLRNHLPPDLLALTAQELESTGLYRLMRASGITLHSARQSVGARAATMGEGRALDEEPGAPLLTMERTTYDDTGRAVEFGSHVYRASRYKFDFQLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS36</accession>
    <name>A0A7K2ZS36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001788">
        <property type="protein sequence ID" value="MYW35190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="85" mass="8958" checksum="B0FECCE22CDED014" modified="2021-04-07" version="1">MSDRLAPRPLSPTPEPLLWHRSSRSTGMNNCVETSRLGGPGPGGPDSGGALLAVRDSKDVDRPPLRFSATAWTTFVAGLDGQQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS64</accession>
    <name>A0A7K2ZS64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001798">
        <property type="protein sequence ID" value="MYW35221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="19923" checksum="1DDAFE254D2E6E47" modified="2021-04-07" version="1" fragment="single">MSMANAVQEYARTLTLRSSTHYRVGPFTVRHNPGWELRYANYAIPDRDAEPTAEDVAALVDAFRERGRLPRLEFLPAWAPAVEPALLAAGFTVENRAPLLVCAREGLRAPKPVDGLRIAVPATDTEFIDAARVQHHGFGGAGEPEPGTTTWLRSAAAGDGVAALAILDSAPAGAGGCSVPVDGLSELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS66</accession>
    <name>A0A7K2ZS66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">GT040_39330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="WWKE01001783">
        <property type="protein sequence ID" value="MYW35172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="48"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="31380" checksum="F9FA407C2A44E428" modified="2021-04-07" version="1">MSGQSLLVPGEITPVRSVPGNIRRPEYVGKPAPKPYTGPEIQDADTIERMRIAGRIAAQAMEEAAKHIAPGVTTDELDRVAHEFMIDHGAYPSTLGYRGFPKSLCSSLNEVICHGIPDSTVLRDGDIVNLDVTAYINGVHGDNNATYLCGDVDEESRLLVERTRESLNRAIKAVRPGRQINVIGRVIESYAKRFGYGVVRDFTGHGINSSFHSGLIIPHYDSPNATTVMQPGMTFTIEPMLTLGTHEYDMWEDGWTVVTKDRKRTAQFEETLVVTETGAEILTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSG2</accession>
    <name>A0A7K2ZSG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001834">
        <property type="protein sequence ID" value="MYW35321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030563091.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001834.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="19134" checksum="9FFA994BBAD9F2E2" modified="2021-04-07" version="1">MDAAQQEATARARELQRSWYGEPLGALFRRLIDDLGLNQARLAAVLGLSAPMLSQLMSGQRAKIGNPAVVQRVQALQELSSQVADGSVSAGEATDRMEEIKKSQGGSVLTGTGQTASTGGAPTVRRVVREIQSLLRSVSAAGDIIDAADALAPTHPELAEFLRVYGAGRTADAVAHYEGHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSI3</accession>
    <name>A0A7K2ZSI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17676" checksum="E806C5EE4C977997" modified="2021-04-07" version="1">MSQPGDGIDLTTSLGYLLKEASSALRAAMEEVLRPLGMSVTHYSCLELLAQRPGMSNSELARGAFVTRQTMNVLLQNLEREGYVTRPTEARVGKALPAQLTPSGRQSLEQATAAVRSVEIRMLSGMTEAEQSDALRSLKSMIRSLREDGNAGDDSDTGDDSVTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSI5</accession>
    <name>A0A7K2ZSI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminodeoxyfutalosine synthase</fullName>
            <shortName evidence="6">AFL synthase</shortName>
            <shortName evidence="6">Aminofutalosine synthase</shortName>
            <ecNumber evidence="6">2.5.1.120</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mqnE</name>
        <name evidence="8" type="ORF">GT040_39815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64286"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="2.5.1.120"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.120" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102573">
        <property type="term" value="F:aminodeoxyfutalosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00993">
        <property type="entry name" value="MqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022432">
        <property type="entry name" value="MqnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03700">
        <property type="entry name" value="mena_SCO4494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="52"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW35258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="387" mass="44046" checksum="2D2ED9BAE84F7DF8" modified="2021-04-07" version="1">MDAGLKRELEQKVRAGERLTREDGIALYASDDLAWLGGLAHEVRTVKNGDVVHFNVNRHLNMTNVCTASCAYCSFQRKPGEKDAYTMRIEEAVSLAKAMEGENLTELHIVNGLHPNLPWRYYPRSLSALKEALPDVALKAFTATEIHHFETISGLSASEILDELIEAGLESLTGGGAEIFDWEVRQHIVDHRTHWEDWSRIHRLAHEKGLKTPATMLYGHIEEPRHRVDHVLRLREMQDETGGFQVFIPLRYQHDFVDMKDGKVRNKLQARTTMATGAEALKTFAVSRLLFDNVPHVKVFWVMHGVQTAQLALQHGADDMDGSVVEYKITHDADDFGTPNKLGREDLLDLIRDAGFRPVERNTRYEILREYPGPEADRRESPQPMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSQ9</accession>
    <name>A0A7K2ZSQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001835">
        <property type="protein sequence ID" value="MYW35338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="27073" checksum="AFE9532A2CBE1F28" modified="2021-04-07" version="1">MGKLDGRVVLVTGAARGQGEQEARLFAAEGARVVVADVLVEQGEALAKELGEEAARFVRLDVGSEEGWAEAVAVARDAFGKIDGLVNNAGILRFNELVNTPLAEFEQVVRVNMTGAFLGIRAVAPEIEAAGGGTIVNTSSYTGLTGMPLVGAYAATKHAVLGLTRVAAMELAGKGVRVNAICPGAIDTAMSNPALLDPDADLSRSDAALDAYYRKLVPMGRIGRPEEVAALALFLTGEDSSYITGQPFVVDGGWLAGVSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5X0</accession>
    <name>A0A7K2Z5X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000004">
        <property type="protein sequence ID" value="MYW27734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11086" checksum="036B75CC4CE6E0D0" modified="2021-04-07" version="1">DAHAARSRRTELAAAHAAREGAGVPGTAERPEAALDRVLVTHELRKLPPVQREILRLAYFDDLTHVQIAERTGLPLGTVKSHARRAILRIRRSIAEGSPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z608</accession>
    <name>A0A7K2Z608_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000007">
        <property type="protein sequence ID" value="MYW27752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029892240" evidence="1">
        <location>
            <begin position="20"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="437" mass="45788" checksum="9F09B9CD919D6657" modified="2021-04-07" version="1">MRHLRAASAVTLAIAIAAAATGCGGGSTGSTGSNESPKTLTYWASNQGPSIEADKEILTPELKKFEKETGIKVKLEVVPWADLLNRILAATASGQGPDVLNIGNTWSASLQATGALLPWDEKNFEAIGGRDRFVDSAVASAGKAGEPPAAVPLYSLAYALYYNKKMFAEAGIDGPPATWDDLVATGKKISKGGKWGLGAEGGNLSNNIHQTFVLGQQHGADFFDKDGKATFTSDGAVAAVKQYIDFMAKDKIIAPGNAEYAQNQSLTDFAKGKTAMVLWQAAASTFAAQGMKPEDWGAAPVPVPAGAPGTGKQVNSMVAGINIAVFKNTKNIDGAKKFVKFMTSDEEQKHLNKTYGSIPPVKEAQADAAFGAPDLKVLRDTLSTSAAPLPQVPNESQFETAVGTAVKELWADAAAGRPVTEASVKARLEKAQQSMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z618</accession>
    <name>A0A7K2Z618_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">aceE</name>
        <name evidence="13" type="ORF">GT040_00500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="WWKE01000014">
        <property type="protein sequence ID" value="MYW27789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="147"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="12">
        <location>
            <begin position="486"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW27789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="890" mass="98004" checksum="95B7B27DB5163EC6" modified="2021-04-07" version="1">MTDPVGKLPSELDQLPDRDPEETAEWAASLDAVTQAAGPHRAAYLMRRSLQHAEGAGLALPKLLETDYVNSIPTAAEPTFDGDLEMESKITAWNRWNAAAMVTRGARYGVGGHIATFASAAWLYETGFNHFFRGKEGDGSGDQLYIQGHASPGIYARAFLDGRISEQQLDHFRQESGGEGLPSYPHPRRLPWLWEFPTVSMGLGPLSAIYQARFNRYLTNRSIKDTSNSHVWAFLGDGEMDEPESTAALALAAREQLDNLTFVINCNLQRLDGPVRANFRVVQELEAQFRGAGWNVVKTLWGNAWDELFQLDTTGALLRRLREVPDAQFQTYATRDVAYIRDHFFGTEPALAELAKLLTDAKIAECFYTSRGGHEARKVYAAYKAAVEHKGAPTVILAQTVKGYTLGKGFESKNANHQMKKLSIDEFKGMRELLGLPIPDSAFEDGLVPYGHPGADSPEVRYLQERRAALGGPAPARRMHASAPLPQPEERAFKALYKGSGKQEMATTMAFVRLVKDLMRDKETGKRWVPIVPDEARTFGMESLFPSAGIYSPLGQTYDPVDRDQLMYYKEAKDGQILNEGITEAGAMADFIAAATSYATHGETMIPFYIFYSMFGWQRTGDQMWQLADQLGKGFIVGATAGRTTLTGEGLQHADGHSHLIAATNPASLNYDPAFAYEVAVIVKDGLRRMYGPDAEDVFYYLTVYNEPKPQPAMPEGVEEGIVKGLYRFKEGTPAKADAPRLQLLASGTAIHWALEAQDLLAADWGVTADVWSATSWGELRRDALEADEALLRGEVQVPYVTQALSGAPGPVLAVSDWMRQVPDQISQWVEQDWSSLGTDGFGLSDTRAAARRHFGVDAQSIVVASLAQLAKRGEVPASAVKEARERYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6D0</accession>
    <name>A0A7K2Z6D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xth</name>
        <name evidence="3" type="ORF">GT040_01125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000055">
        <property type="protein sequence ID" value="MYW27909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="29923" checksum="AD815A51713B260B" modified="2021-04-07" version="1">MLTITSVNVNGLRAAAKKGFVEWLAGTEADVVCLQEVRAEPGQLAEEVRTPEGWHTVHAPAAAKGRAGVSLYSRQAPERVQIGFGGFDVPGAEEFDASGRYVEIDLPGVTVASLYLPSGEVGTERQEEKERFMAAFLPYLQGLKTRAAADGREVVVCGDWNIAHQEADLKNWKANQKSSGFLPEERAWLTRVLDEAAYVDVVRQLHPDVAGPYSWWSYRGRAFDNDAGWRIDYQIATPGLAARAVKAWVERAATHGERWSDHAPVTVVYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6D7</accession>
    <name>A0A7K2Z6D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000055">
        <property type="protein sequence ID" value="MYW27905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515745.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000055.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="297" mass="32225" checksum="B6078F886F6E9700" modified="2021-04-07" version="1">MSSRRSLEGQVVVVTGAARGVGELLARKLSARGATLALVGLEPDELKKVSERLHGESDHWFADVTDHTAMAQVAREVKERFGKVDVVVANAGVASGGPFADSDPDAWRRVIEVNLIGGAVTGRAFLPVLMESRGYFLQIASLAAITPAPMMTAYCASKSGVEAFAHSLRAEVGYKGVKVGVGYLSWTDTDMVRGADQDDVMRELRQRLPWPMNRTYPLGPAVDRIVDGIARRSPHVYAQWWLRGMQSVRGYLPSVIAVGGQREMRRFEPRLHTVSKGLVGAGGAADQDARAERADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6H3</accession>
    <name>A0A7K2Z6H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_01335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000059">
        <property type="protein sequence ID" value="MYW27949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW27949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="349" mass="36318" checksum="4247BA19DBF016BA" modified="2021-04-07" version="1">MRGVVFDGTRTEVVDDLEIRDPGPGEVLVAVAAAGLCHSDLSVIDGTIPFPVPVVLGHEGAGVVEAVGPGVSHVRPGDHVALSTLANCGACAECDRGRPTMCRKAIGRPGRPFSRGGGKLFQFASNSAFAERTLVRAVQAVKIPADLPLTSAALIGCGVLTGVGAVLNRAKVDRGDTVVVIGTGGIGLNVLQGARLAGALTVVAVDSNPAKEAVARQFGATHFLTSAEGVRDILPDGADHAFECVGRTELVRQAIDLLDRHGQAVLLGVPAASAEASFTVSSMYLDKSILGCRYGSSRPQRDIALYADLYREGRLLLDELVTETYPVEDFAKAADDAHHGRVARGVLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6K6</accession>
    <name>A0A7K2Z6K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000059">
        <property type="protein sequence ID" value="MYW27952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="33004" checksum="B5BAAA90EF1551CC" modified="2021-04-07" version="1">MSLPAEFHELAKRVNNWGRWGEADERGTLNLITDAVVREAVGAVRSGRRIPLALPLRHGGVQSGFIPGRIDPLHTMVQINQEMFGPGTVATSDDTVTMGLQAATHWDALTHASHGGRIYNGRPADTITAHAGAQFSSIAAVEHVVSRGVLLDVARARGVDRLAGDHAVTPEDLDAAEEFGGVRVRAGDIVLIRTGQVQVVLAGDRQAYGYPSPGLSVRTPEWFHARDVAAVANDTLTFEIFPPEIEDLWLPVHALHLVEMGMLQGQNWDLEALSTACAEARRYAFLLTAAPEPFTGATGSPVAPVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z767</accession>
    <name>A0A7K2Z767_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CbtB-domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000113">
        <property type="protein sequence ID" value="MYW28197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513014.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000113.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7273" checksum="534F4ABB73BF3E99" modified="2021-04-07" version="1">MAQSAAPATGAPAIVPISAKALAPWAVFVGILALVLLYFVGAEQGATALISGEGVHEWVHDGRHLLGFPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7S9</accession>
    <name>A0A7K2Z7S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ketoacyl-ACP synthase II</fullName>
            <ecNumber evidence="5">2.3.1.179</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_03520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000147">
        <property type="protein sequence ID" value="MYW28365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="5"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="423" mass="44486" checksum="1B38A6DD693D5406" modified="2021-04-07" version="1">MSRRVVITGIGVVAPGGVGTKEFWSLLTAGKTATRPISTFDASQFRSRIAAEADFDPLDHGLTEEEAARLDRAAQFALVSTDEALRDSGLDTAELDPTRTGVTLGSAVGCTMGLDTEYNNVSRGGSTWEVDHTLAVPHLFDYFVPSSLAAEVAWRAGAQGPVALVSTGCTSGLDSIGHAVELIREGSADMMITGATEAPISPITVACFDAIKATSPRNEEAETASRPFDATRNGFVLGEGSAVLILEELESARRRGAHVYAEIAGFASRCNAYHMTGLRPDGAEMAEAITAALDEARLDRTAVDYVNAHGSGTKQNDRHETAAFKRSLGPHAYDIPVSSIKSMIGHSLGAIGSLEVAASALAIERNTVPPTANLHHADPACDLDYTPLTAREQRTDTVLSVGSGFGGFQSAMILTRPRPGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z811</accession>
    <name>A0A7K2Z811_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_04140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000188">
        <property type="protein sequence ID" value="MYW28486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="4">
        <location>
            <begin position="58"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="274"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="462" mass="49007" checksum="5A3AB9BD7BDEE3C4" modified="2021-04-07" version="1">MATAYGPDTRDHKGSGTRGHSGHTGQGAGPQGQAPVKHFLPAALRAPLEARSWRELLYVVLSLPLSTAMFVFAITMTSVSAGLLITFIGIPLLAVGLAACRGFGVMERARARGLLKLDVAEPVRVRGKSGGPMSWIGAVLKSGVSWRHLLYALLHFPWAVFTFCVSVTFWAYGLAALTYPLWKWVFPVFAGADGIQLYGDRTHAEYLDSPVELAATSAVGLVLVLVSPWIVRGLLSVDRLMVSGLLGPSALSARVTELESDRGVVVDTAAADLRRIERDLHDGAQARLVALAMDLGLAKEKLSNDPEAAARMVDEAHGEVKVALQELRDLARGIHPAVLTDRGLDAALSAIASRCTVPVTVEVDLDARPAQAIEGIAYFTVSELLQNVSKHARATRATVDVWRTSDRLMLQVTDNGRGGASASAGSGLAGLTERLDAVDGVLVVHSPAGGPTTVTAELPWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z822</accession>
    <name>A0A7K2Z822_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lytic transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000172">
        <property type="protein sequence ID" value="MYW28455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT_2" evidence="2">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="293" mass="29370" checksum="372758CD80139AE9" modified="2021-04-07" version="1" fragment="single">AASQAPAAPLAEGSTAGDQQAAGGESGGPEDGAATGNSPYYTDLPPLVTPDRPGSSSNLPAATGSAEAGIPASVLAAYKQAEQTVGTTDPACRLPWQLLAAIGKVESGQARGGQVDANGTTLSPILGPALNGQGFALIKDTDGGAYDGDAVHDRAVGPMQFIPSTWATWGQDANGDGRKDPNNIYDAALAAGRYLCAGGRNLAVAADLDRAVLSYNQSTEYLRTVRSWFAYYQRGTHEVPDGSGVLPTAPSTPTPSPTPSPGGTVSPTPGGTTGPKPSPSKSGGTKPSPSPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8F5</accession>
    <name>A0A7K2Z8F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000210">
        <property type="protein sequence ID" value="MYW28602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="34" mass="3608" checksum="93C388A9F0BD88DF" modified="2021-04-07" version="1" fragment="single">MSAPDRPAGTGRLLTGVAWAVLLLGLWLWGRDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8W6</accession>
    <name>A0A7K2Z8W6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_05675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040868">
        <property type="entry name" value="DraK_HK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18092">
        <property type="entry name" value="DraK_HK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="209"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="421" mass="45342" checksum="477E503248C53F62" modified="2021-04-07" version="1">MRRRLINSTLAVVLVVIAVFGVSLVIVETRTISASAQESVESEALRLISVVDSRLLGDEVINSGVLSEQIDPNRFALIEIPGRAPIAVGERPSGSVLRATETGEQGEKVTVEESRSAVTREVGRTLLIIGAVALLAIISAVLLAVRQANRLASPLTDLAETAERLGSGDPRPRHKRYGVPELDRVADVLDSSAERIARMLTAERRLAADASHQLRTPLTALSMRIEEISVTDDPETVKEEANIALTQVERLTDVVERLLTNSRDPRTGSAVVFDLDEVIKQQIEEWRPAYRSTGRALVCSGKHGLRAVGTPGAVAQVLAALIENSLMHGGGTVALRTRVTGNQVVIEVTDEGPGVPAELGARIFERTISGRNSTGIGLAVARDLAEADGGRLELLQQHPAVFALFLSRIPLDRKEPERPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9A8</accession>
    <name>A0A7K2Z9A8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_06470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000298">
        <property type="protein sequence ID" value="MYW28926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="58"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="461" mass="49530" checksum="22E40EAC3CDEDE3A" modified="2021-04-07" version="1">MRVLAVVGPASLSLALGLWGIRRQNTMWGDEAVTYRLAQRELYQLWETVQQVDLVHALYYAVMHVVFDVFGAGLLSLRLPSVLAMAAAAGGVGLLGLLLAGPRAGVTAGLVFALLPQVQKYAQEGRSYAMVCALIVWATCALVVSSSRRGRRRWTVYGFVMLLACLLHEFAVLGLAAHGVTLIVSRPPKAVLRAWSFTAAGVVAGLLPLAIVSAGQSEQVSWIGGPVRPYPWLAAVMVGLVCTRAPLRSRGTVRLTALAVPLLVLPGALLLIVSLVKPIFVDRYVLFSDIGLALLLGAFVEYVHKLPRYSWTVYVAVPAALVALAPLSNSLRTPQSRSNDATAIGAAIRTEGRPGDGLLYLSGGQRTLTAADPDDTRLLVDIALARDPVASNTLAGVERPAPEIAARMKQFDRIVVVRAGGMHAPGDPREEVKRETLRRHFRAQTTNEVNGARVTLYTRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA92</accession>
    <name>A0A7K2ZA92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_07995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000367">
        <property type="protein sequence ID" value="MYW29222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="26743" checksum="A268C90B98840FD8" modified="2021-04-07" version="1">MTVISTAGLARTFATPNGPVEAVRSVDLTIRAGEIVGLLGPNGAGKTTTLRMLTTLLTPTGGAATVAGHDLLTDPAAVRAVCGYVAQSGGVDPYLTVREELVTQGRLYRLGRAEAAARAGELAAALGLEGLLDRKAVSLSGGQRRRLDIAMGLTHRPAVLFLDEPTTGLDPGSRAGLWDLVRSLRDETGTTVVLTTHYLDEADALADRLILIDGGTVVAEGTPAELKARYAGSPDASLQDAFLAATGRPVTPADAAPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAF7</accession>
    <name>A0A7K2ZAF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000402">
        <property type="protein sequence ID" value="MYW29324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="454" mass="48422" checksum="959C7BD367688F7F" modified="2021-04-07" version="1" fragment="single">MTQLPQGGPQTQRAPEQAPAPTGLPAQRPVSWAVQSRRLRAVATTEPGRLQIIGAVLALLVVAFGAVTALEISHRASAADDVVGRSQPLSADAASIYRSLADADTMAAGGFLAGAQEPKAVQEQYRKDIEEAARLLVKASANTDSSTSSWREITTLNEVLPVYTGLIERARANNRQGLPLGGAYLRYANQKMTDELLPAAERLYAEETGRLDRDAADARRWPFLSLAAGLVVLGALVWMQRRNYRRTNRVFNHGLLVATAAASVVLIWLAVGHTVARTELRSAMTQGQESLDVLNNARINSLKARANENLTLVARGAVLTADGSADQYETDYTTGMKALRAQLKEAERLADDESGSAPVAKAAKSVTEWQERHRKARATDDRGDYEGALQQIIGAEDSTGQSFQQVDSALRTALAHEQGEFTAAAEDGRGALRGLPTGAAALAVLGAVAAILGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAJ0</accession>
    <name>A0A7K2ZAJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="8551" checksum="78BF9144117FD9FB" modified="2021-04-07" version="1">MTPRLDRDAFHRAWAWLGDHRGAQAAVQTLRRGQPYAYELATPAARWRWTAYPVSVLPPPHHHLPNEHPVRSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAV2</accession>
    <name>A0A7K2ZAV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2087 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000410">
        <property type="protein sequence ID" value="MYW29405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2087" evidence="1">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="11310" checksum="BEF6F729CFFAB788" modified="2021-04-07" version="1">MSEQSTLPPQQPVRRTHQVSALFTHGRLVTIPRKQARLEQLLVHLAETLFERDRSYTEQEVNEALLTVHEDCSALRRHLVVAGLLVRPRDGSSYRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB32</accession>
    <name>A0A7K2ZB32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_09735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000451">
        <property type="protein sequence ID" value="MYW29549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="26223" checksum="AF3D6C64313F2E75" modified="2021-04-07" version="1">MERARQGPRARYREQTRAEIKDLALRQLAEGGGAALALTRIAKEMGLSGPALYRYFAGRDDLLNALIRDAYDDAAAAMARAAARSAKGSRGVRARLHDLAEAYHTWAIAEPHRYLLIQGAPVPGYVAPADTLERARAVLGPFLPLFATGTPGPAVAATVDEMTAWLAADGTVGAWVARYAPEAAGTPDALAGQARAASALAGAVLAWTQLHGSVSLEVAGQFAGMAHRGGTLLGAHMEMLADAFGLDQTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB51</accession>
    <name>A0A7K2ZB51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WXG100 family type VII secretion target</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000437">
        <property type="protein sequence ID" value="MYW29505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8883" checksum="50EBB08CFDF0EC4C" modified="2021-04-07" version="1" fragment="single">MADGIIDVQYSTVRNAIEELKQQTQQIITTLNNLEDELKPLITSWEGDDQAMYRGVQAEWDQATKNMALLLGDSGDLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB65</accession>
    <name>A0A7K2ZB65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_09750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000451">
        <property type="protein sequence ID" value="MYW29552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029525820" evidence="2">
        <location>
            <begin position="46"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="740"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="938"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1166" mass="125105" checksum="78102E8CAAB96B91" modified="2021-04-07" version="1">MNRRSSRRAGRVGRSPGAPSPLIAVTSLLALVLALLVAAPPPAQAAAPYRVLVYSEVTNFTHDSIPAGIEAVKKLGAEHGFEVEATEDSAVFNDADLGRFQAVVFNNTNSTPEKGDLLTTDERAALQRFIRAGGGWVGVHAASASERDWDWYEGLVGAIFDQHPEVQTGRVKVLDRAHPSTEHLPDLWERTEEWYNWRSNPTSKVHTLAQIKVRDGVTGLDEGVDHPFSWCQNYDGGRSWFTAGGHDKAAFQEETFVRHLLGGIQWAAGAAEGDCTATRTGSFQRTALATSDLADPFELAIAPDRRVFFAQRTGKLKVIDQETMKVSTALDFAYTPEMTSQSDGLLGLTLDPGFAENNWLYLLYSDKVEKRLNLSRFTVDGNTVDPASEKRLLTVPTLRGEGRANSHMAGSLAFDKDGNLYAATGDNTDPFASDGFTPIDEGEGRRAWDAQMTAGNTDDLRGKILRITPQDDGTYSVPEGNLFAPGTAKTRAEIYAMGMRNPFRITTDPLSGALMVADYGPDARQAVADRGPEGTVEYTRITKAGNFGWPYCIGNNTPFNDYDFVAKKSGPKFDCAAPVNDSPNNTGLRELPPAQPATVWYAYSASAEFPELGTGGGGPMGGPVYDYDPDNTYRTKFPAYFEGKAFNYELTRRWFKTFSFQSEDQTFTDPRFDPVKEGDLHSINGIFEDMEWNQPFDADFGPDGALYVIDFGLGSGTGRGGSNEGAGIYRIDHVGDGRLPDAKLSVDRDSGPAPLTVKFSSEGSGLPGDQPVTYAWDFDGDGTTDSTEAAPTHTYTAKGLHTARLTVTGPDELTALAVQDITVGNTRPEVTIQQPPDGGMFSFGDTIPFTVEVTDEEDGQSGPIDCSRVVVQSQLGHDTHLHPLDNYTGCAGEIVTDAGDSHGPGQNLYYGITAQYEDKGAPDAPALTGSTSLTLRTSHREAEHFISTGGRNGGAEVGSRADASGGKRLIEIEDGDWVTFDPVNLKGVDSVTVGASSGGLGGTVEFRSGSPTGELLGSVTVPSTVGWEKLISPTTDLKDPGGTTKLYAVFTNPEWSEGKADLLSVDWLHFNGPGVEKAGGTEVAVQAEPASGTAPLTVALSSTVEPAEGRTIASYHWDFGDNVKPTGPEGATATHRYDRKGAYTAHLTVTDNKGDTTTGAVRIDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBU5</accession>
    <name>A0A7K2ZBU5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">idi</name>
        <name evidence="9" type="ORF">GT040_11090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="WWKE01000501">
        <property type="protein sequence ID" value="MYW29813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241701.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000501.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="21137" checksum="B79B824DC165BBAE" modified="2021-04-07" version="1">MPTTPATATHSSSNGTAEAIMLELVDENGTTIGTAEKLAAHQAPGQLHRAFSVFLFDEQGRLLLQRRALGKYHSPGVWSNTCCGHPYPGEAPFAAAARRTYEELGIAPSLLAEAGTVRYNHPDPASGLVEQEFNHLFVGMAQEALKPDPEEVGETAFVTAAELAERHARAPFSAWFMTVLDAARPAIRELTGPSAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBV1</accession>
    <name>A0A7K2ZBV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_10750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000491">
        <property type="protein sequence ID" value="MYW29745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="31985" checksum="792B3A3069E1E7E0" modified="2021-04-07" version="1">MRKPGPAGIAVGRPGFLWAAPAALFFGLFAIVPLIMVAVLSFASWDGLSDPEFAGLANWKKLLDDPVMIKSLWLSVLLTALGVLVQTPLSILLGVWAAGHQRNRAVLSAIYFVPMLLSIAAVSVLWRALLDPNLGVPAQATWLFGDGNLFGMQASAIGVLVFVSTWQFTPLHTLIYQGAARAVPPVLYQAAQIDGAGRARQFFHITLPQLRNAIITSMILMVVGGLTTFDTVLILTQGGPGSDTTISAFYMYQKAFKSFDYGSASAIALLLVLVSTLISLIVVRLSGYDKMRSTMEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBY5</accession>
    <name>A0A7K2ZBY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000516">
        <property type="protein sequence ID" value="MYW29866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="20681" checksum="8DE5EA56A376E856" modified="2021-04-07" version="1" fragment="single">MAREFQRGHKAKISDLTPGTDLYVGVQIAAPGLTFDISCFGLDADEQLSDDRYFIFFNQPKSPEESIQLLGAQSGDTESFRVTLDRIPATIHKLSFTATLDGAGQMSQVGPGYIRIVAGGEEVVRYAFTGSEFTTERAVMLGDFYLKDVWRFAAVGQGFDGGLDALLKNFGGEVAEEEEAPAAPQAAPGFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBZ1</accession>
    <name>A0A7K2ZBZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiF family adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000516">
        <property type="protein sequence ID" value="MYW29864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="16268" checksum="385391FD449183D9" modified="2021-04-07" version="1" fragment="single">MHPMLKPALRRAWRGRNTVQFGVTPAHAVTLGPVDIATGSFLELLDGTRGLPLLREEARTLDLSDRHVDILVRRLAEAGLLDDPRAAGPQADVLRHRAEVMERQRPDVASLSVVHPGPGEGLRRMAARRAMRVQVRGAGRVGASIAAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCC9</accession>
    <name>A0A7K2ZCC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000558">
        <property type="protein sequence ID" value="MYW30017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="21656" checksum="6DF4121339113C15" modified="2021-04-07" version="1">MNPPDEGVAGELPGVAPRLRDLRRGRGLTLETAAQRAGLSPAHLSRLETGRRQPSLPMLLGLARIYGTTVSELLGEKPPEREAVIRGGAFEGAEADGWMYRRAGGSGRAMQALRVRVPYGAQGDLVRVHPGEEWLYVLGGRLRVALGETVHDLDPGDSAHFDSLTPHRIAALDRGGAELLFVHSLLQSPAAELCLGNALHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCD7</accession>
    <name>A0A7K2ZCD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000558">
        <property type="protein sequence ID" value="MYW30016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="270" mass="29651" checksum="10460E1097686237" modified="2021-04-07" version="1">MTQQVPQVPPTETALTGVRNFRDVGGLPTEDGRRTAFGRLYRSGHLAHATAEDALFLGGLGLHTVFDFRNSADHQLDGYDIELAGVRNVSIPLSDPADGAEFWRLVRDGNIEQLRSILANGKGTERMITMYRSTIVDRTAEHSRVLHSLAEDSVPALMHCAAGKDRAGLSIAVSLLAVGVEREAIEADYLKSNDPHRRYKVKRTDMSETGMSPEVMELLNPLFGAQSSYLAAAFAAIDDTWGTTDRYLAEGLGVSPETRERLRERLLDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCG7</accession>
    <name>A0A7K2ZCG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000557">
        <property type="protein sequence ID" value="MYW30012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="40" mass="4215" checksum="A398791693DFDE50" modified="2021-04-07" version="1">AAADAELAAARPLPDNGYKVTLMRNLMVSVLTELAEGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCQ2</accession>
    <name>A0A7K2ZCQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000598">
        <property type="protein sequence ID" value="MYW30126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="26"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="406" mass="42591" checksum="318E1A23604BD639" modified="2021-04-07" version="1">MTDVRGPARRFVARIEAATPPGRDRAVDALRALAILGVVGGHWLVTALVADSGTVRGASPLTYLPELTPVSWVFQTLAVFFLVGGQVAARSWASARERGVPYGRWVGGRLTRLFRPVAAVVVVWSLAAGVMLVAGVGEPTVSALAKLVWSPLWFLLVFAALTALTPLVARLHPLWPLVVVLHVDLVRFGLGGPRELGWINVIAGWLVPYCLGALVARGGLRGRGNRWALLVCGGAAAGALVLWAGYPGAMVGVPGGRISNLDPPSLAAVAFGLAQCGAALLLLGPLRRALRRPAAWAAVAVVNLSAMTVFLWHQTAMIVVTAGALLVAGGPLPGLHTVPDGVGWVVARLLWLPVFALALVVCWAAFRGHEQGGRREGTRSLLVRESSSPGPSPGSSPGRKQEVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCQ5</accession>
    <name>A0A7K2ZCQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000596">
        <property type="protein sequence ID" value="MYW30088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="27916" checksum="A6C47328C13CE40C" modified="2021-04-07" version="1">MSAPETVTSSKSPNAGKKAKDLNEVIRYTLWSVFKLRDVLPLDRAGYADEVQELFDQLAAKDITVRGTYDVSGLRADADLMIWWHAETSDELQEAYNLFRRTKLGRALEPVWSNMALHRPAEFNKSHVPAFLADETPRDYISVYPFVRSYDWYLLPDEDRRRMLADHGKMARGYPDVRANTVASFSLGDYEWVLAFEADELYRIVDLMRHLRASEARLHVREEVPFYTGRRKSVHDLVAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCY8</accession>
    <name>A0A7K2ZCY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000604">
        <property type="protein sequence ID" value="MYW30179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="78"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="519" mass="56373" checksum="26CA86B5F06A4D14" modified="2021-04-07" version="1">MRSLRIWIPLLCTAVLAAGAGVRLLLSEDGDRERPISVGTTDVVGGLDPAGSYDTGSWALYSNLYQSLLTLRPGSAAPVPDAAESCRFLDASLTAYACTLRAGLTFANGHPLTAQDVRFSFERMLGIGTDIGPATLFAGLDSVSARGRTVTFGLRERDATFPLKLATGAGAIVDRSRYPGEALRPGTAVDGSGPYTLAAYTPGLRALLEPNPRYRGAVAVPRSAVEVRYFEDAEQLADAWRRGGVEVAHRQLPSDLTSTYEPGEESGRMTEAAAAEIRTVVFDLRPGSPLARREVRQAVAVLVDRGRITAGVHHSTVEPLYSLIPRGLTGHTTSFFDRYFRDDDATARARSLLRRAGVHTPVAFTYGHRSGTAFAAEAAELRRQLEAAGLFRVRTVSAEWKQFQKGYASGAYDAYGLGWVPDFPDPDNFTTPLVGRSNALHNTYASPRVDRLISLTQRHGDRRKASGVFREIQDEIAVDVPVLPLWQRKDYVLAAPGVAGSEHLSDGTGVWRLWRLSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCZ4</accession>
    <name>A0A7K2ZCZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_13235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000612">
        <property type="protein sequence ID" value="MYW30224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="286"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="553" mass="58966" checksum="D82FE6DFC2977436" modified="2021-04-07" version="1">MTTRELLKATREPLVDVSDLTVDFGSVRAVDGLSFTLEAGGALGVVGESGSGKSASAYALLGLHRGTGARVGGTVKVAGTDVNAADDAGLRALRGAKAAMVFQDPLSSLDPYYPVGDQIAEVYRVHHRASRRAARARAVEVLDRVGIPDAARRSRLRPHEFSGGMRQRALIAMALACEPRLIVADEPTTALDVTVQAQILDLLHTLRQETGMGLLLVTHDVGVAAESVDDVLVMRDGREVERGPVARVLGSPREAYTKELLAAVPRVETRRVVPAQRVPEESVPLLEAVDLRREFGRGSGQVAAVGGVSLTVHAGQTLGIVGESGSGKTTLGRMLVRLLDPTAGRLRYGGTEIGSLSEKELRPFRRELQMVFQDPVASLNPRRSVGESVADPLRAAGERDDGRVRDRVGALLERVGLDPAHFERYPHEFSGGQRQRIGIARALAAEPKVIVCDEPVSALDVTTQAQVVALLAELQRELGIGLVFIAHDLAVVRQVSDRVAVMRGGLIVEQGSADEVYGDPQDPYTKQLLAAVPALDPGLAAVRRAARRELAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDJ6</accession>
    <name>A0A7K2ZDJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000655">
        <property type="protein sequence ID" value="MYW30345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="SSF142921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WGR" evidence="1">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="486" mass="51959" checksum="0131CB4769136A97" modified="2021-04-07" version="1">MSAASTTVPTTTYLELSQEGAGAHKFYEVTVDGLVVTVRYGRIGAAGQVQASAFATVAKAQAAAAKKVGEKVRKGYAPAVPGQRAPRAVTRRQVTSAPSTARSVAPVLWRFRTGSSAFGIHVDDERCWVGNQAGDVYTLDHDGAVLARFSLPDGVKCLVADDFWIYAGCDDGRVYDLSSKLPFAAYDIAADVDIFWLDIHEGLLNVSDRDGRLTVIDHEDEHQWARRSQGEHAWMVRADDRAVYHGHHRGVTAYTPDGGGELWHTPTRGGVLFGWQEDDAVYAGTAHRVVQRLAKATGAIEATYACDSAVYSCATSPGGRFVFAGDASSSVYCFDRDGTRLWKLGTGGGSALSMQYRDGRLYLVTTDGSLVCVDASEAAISAAQQGTVPAPRDVKLAAALPTYAPATAVAAVTTVTHAPAGSVVVECVQDTGDRIRVHVVSGGYDTSWNVQFPRAIREPGARYVVDALHAAAGGFYRVRGDIRRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDR7</accession>
    <name>A0A7K2ZDR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">GT040_14685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000690">
        <property type="protein sequence ID" value="MYW30494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="379" mass="40521" checksum="686DF083CB30E6E7" modified="2021-04-07" version="1">MATDYYAVLGVRRDASQDEIKKAFRRLARELHPDVNPDPKTQERFKEINAAYEVLSDPQKKQVYDLGGDPLSANGGGGGAGGFGAGGFGNFSDIMDAFFGTASQRGPRSRTRRGQDAMIRLEIDLAEAAFGTTKDIQVDTAVVCNTCSGEGAAPGTSAQTCDMCRGRGEVSQVTRSFLGQVMTSRPCPQCQGFGTVVPTPCPECAGDGRIRSRRTLTVKIPAGVDNGTRIQLAGEGEVGPGGGPPGDLYVEIHELPHSVFQRRGDDLHCTVTIPMTAAALGTKCPLETLDGVEEIDIRPGTQSGQSVPLHGRGITHLRGGGRGDLIVHVEVTTPSKLDAEQERLLREFSKLRGEERPLGQFQPGQQGLFSRLKDAFNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDU6</accession>
    <name>A0A7K2ZDU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_14885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000713">
        <property type="protein sequence ID" value="MYW30533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="145"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="35513" checksum="D27FE692A81FF3EF" modified="2021-04-07" version="1">MRQRPGFDSALTVLAPVVWGSTYLVTTQFLPPDRPLLAAAVRALPGGLILTLAGRRLPQGHWWWRILALGALNIGVFFYLLFVAAYHLPGGVAALVGSIQPVFVLLLSALLLREVVRGRQVAACVLGTAGVGMLVLGPEAGLDAIGVAAGLGGAACMASGIVLTKRWGRPPGVGLLTFTGWQLAVGGLLIAPVALAAEGLPDRLTWTNVAGFGYLSLIGALLAYAVWFRGIERLPALTVSLLGFASPLAATALGYLFLRQGLTLVQGAGAIAVIGAVLLAQRSSAREPLEPDPPPETAGTGTESPTAAGPAHPAPPSPQAGNRSAARSSRPIAESRQTTEREQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDX0</accession>
    <name>A0A7K2ZDX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000681">
        <property type="protein sequence ID" value="MYW30475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="221" mass="23059" checksum="2903E4DC2AF66004" modified="2021-04-07" version="1" fragment="single">MAWHDGTVTAPLTPPHQPNPHDPWQSPPSGSHLAPAYGSPDDPDTATELRQAAVVLVLVALAGIALGLLWLWLAPRVPLVSDGSAVFLQNSEGEEAIGADGTFVLLAAVFGVLSAAAVAWRLRRGGVLVVVGLALGGVLGSLLAWRVGIWLGPSSDVVARAREVGKGVVFDAPLELHAVVVAVLVWPFVALAVHVLLTAAFGVREPEPAWVGEGWTSYYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE27</accession>
    <name>A0A7K2ZE27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="25242" checksum="BBCB080F54325F60" modified="2021-04-07" version="1">MAEHDAERTGSDEEREPRPTENAAVPEGTTKPAVPEGAEPEKRADEERGIDEDAAWAAIVAGYGEEPPDPPGAKPFKSVEDLALLEDDQRNVVGPDNGRAGDPADKGSGKTPPKPPEEKPLGSSVVFAPGVAGPRDYELSEPKDDGIDVPDDGEEGHFVPPEPPPLPEADTTAKFAWLAVIGGPVLMLLAVLLQWHMTWWLTTLCVGGFLGGFVTLVARMPHDDDDDSYGDPGRGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE64</accession>
    <name>A0A7K2ZE64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_15340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000721">
        <property type="protein sequence ID" value="MYW30616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="43"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="409" mass="42393" checksum="F48A7C5ADA1778B0" modified="2021-04-07" version="1" fragment="single">MSANRTTDRRGGARSRLRAARLGPRDVLHVGSSGLRSRPMRVALSALGIAIGIATMIAVVGISASSQAQLLRELDKLGTNLLVASPGDSMFAGEEVHLPEGSVGMVGRIKGVQEVGATADLDATVRRTEKIDEDDTGGIGVKATTADLLRVLRGEVTEGSWLNAATGRYPSVVLGHVSAERLGITKPGQQVWIGDRYFTVTGILAPLPLAPEIERSALVGWEGAKRLLGFAGHPTSIYERSDDAAVQDVRKVMAATVDPQNPQNVKVTDPSSALRAKAATEGAFSTLLLGLGGIALLVGGVGVANTMIISVLERRYEIGLRRSLGATRGQIRIQFVTESLMLSGLGGLAGVALGAAATGVYAHTGGLPWVVPLWAVAGGFGATLVIGTVAGLYPAVRASRLSPTLALHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEB8</accession>
    <name>A0A7K2ZEB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000731">
        <property type="protein sequence ID" value="MYW30676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7442" checksum="93C04CEFE774F5DC" modified="2021-04-07" version="1">MSEDPESVSAAVPEASGVTPDRLLHTGASDTPSAEDVVLASGRDLTPENLEWARRKLADEGRSALDRQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEC5</accession>
    <name>A0A7K2ZEC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000723">
        <property type="protein sequence ID" value="MYW30635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="390" mass="42035" checksum="43CD26CEA9274248" modified="2021-04-07" version="1" fragment="single">MIEEGGGPGGCPASREEPREKPPVAHSRTLRFWLDPANIAVRLGQAGPVTRTKAGPAVAFQVNDPSLIRKVGCGEDIFQAWSADPCLRDFTGNGFAGSEGQPHRDRRALMKPALAAPRLTALGPAVRDSTEGLLAGLPADRPVDIPVEMSRIVAGLVIETVLKSGISPDTLAGLARARSVLSAGVFWTYALSPWPWVPTPRGRAFRRALGTLNEATREVYERHRPDGDGNDVVSLLKRSCDNRPDEALHDLRALLFAGIEATASTLAWACYELGRHPDHQAAIRAEADAVLGTDAPADAVRPDLMPRTTGFVREVTRLHGIPFLVRRPRHATNVGEHPVPAGALVTLPLGALRRDPARYARPEEFDPLRWSPEAHPQLSPAALLPYGLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEG1</accession>
    <name>A0A7K2ZEG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000756">
        <property type="protein sequence ID" value="MYW30743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="193" mass="20387" checksum="062C399D950C9C38" modified="2021-04-07" version="1">MEDPVPEPVGVRRAQAQRTRSGVLAAASAIFVDQGVQAPVRDIAERAGVGVGTIYRNFPTRADLVTAVYRHQIDTCAALAPRLLAESASPFTALTRWMDAFVEFLVTKHGLGAALGSDDPGLENLHALMLDTLVPACATLLDACAAADEIGPGISAYTLMRAVGNLCITGPDYERADARRMVATLLAGCRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEK9</accession>
    <name>A0A7K2ZEK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000762">
        <property type="protein sequence ID" value="MYW30794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23188" checksum="0DD03194F5B06A4A" modified="2021-04-07" version="1">MSGTGAEDLNVDPVSVQQITTGLREAVAELKEIGTGTGAVLGKGLSELSMTGMEAGHHGLSVDFEDFCERWEWGVRALVQDANAIAAKLGLAAGIVWEEDRYVEGTFKIAVNAGVGNPHASEDEIVQQDWGDVFTPDYLSPDYSQESFERTADEAGQTWKDTGRALVTEGNGGRQADQLNEMFGVDRDAFDRSVDDMFGPSPEERARQQEQGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZES9</accession>
    <name>A0A7K2ZES9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000770">
        <property type="protein sequence ID" value="MYW30864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="29791" checksum="6FC458D5294C43C8" modified="2021-04-07" version="1">MTLSDQVAIVTGGGRGIGRAIALALVREGARVALLARTREELEETAALAGEDRSRVLVTPADITDEQAVGRVVKQVDDHFGPVSLLVNNAATYTIGEPPLWEADLDDWWRTVEVNVRGPLVCSRAVLPTMLSEGRGRVITVASDLGALPCPLTAYQFSKAARIRITESLGLSLDASGDTGVRTFSVNPGSVRTRMTEPFAARFPDHDWTPAEESGRLVAALATGRYDALHGRYLSVHEDLDRLLGRIAEVREQELYVERMRVFGPDGAVTSNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF79</accession>
    <name>A0A7K2ZF79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pgeF</name>
        <name evidence="10" type="ORF">GT040_17440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000815">
        <property type="protein sequence ID" value="MYW31014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW31014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="246" mass="25524" checksum="CF00B208F7F6FB8F" modified="2021-04-07" version="1">MIGQHQAEPVTGSAHFAFTDRWGGVSAAPYGELNLGGAVGDDPAAVGANRERAARRLGLDPASVVWMNQVHGRDVAVVDGPWGAEAEIPAVDALVTTRRGLALAVLTADCTPVLLVDPVAGVVGAAHAGRPGLVAGVVPAVVEAMTVRGARPSRITAHTGPAVCGRCYEVPEEMRTEVADAVPGTWSETSWGTPAVDVTGGVHAQLAALGVSDLHRSPVCTRESGDHFSYRRDRTTGRLAGYVWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFI5</accession>
    <name>A0A7K2ZFI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18100</name>
        <name evidence="3" type="ORF">GT040_27575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000857">
        <property type="protein sequence ID" value="MYW31134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001296">
        <property type="protein sequence ID" value="MYW32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="465" mass="50783" checksum="C9FDCF2FD875CFC8" modified="2021-04-07" version="1">MGAPRLRVVIEHDAPEDARRISALYWEIKDDGTWARTVGSIGVAGDIGAVATAHSYATLLNCPCANCSEPITVTNRSWANKVGGKNLDAEAPAYLCGECTKIQQQEETERQRRAAEQKRIEREHEQQQAERLQRLVAHALADEGRKTEPADPLPKDSPLALALYVALIGYATRNPGKPLPSLTSTGPLGWTGDAEQDRELLSDLYDAKLLALAPESPPQAFTLSQDGDGIAFFSTEVAWRVVGGLTAAQERVTKIEDDLRTRPGAEPAEAREAFTALVDRLEVLDVSGYLDNLLTKKYGYPAVPEARREELADVIRKGFAHGYTSGQMICFAWRAADSAAAWKERNPRMGPPEAASASVTSLSGKIDKAIELHHSIPEYEAPRWHASPLALACFRRLHADIRRVYAREVIGACTQCDHLGLKETVHPETGADTVWRCTHPVEIPAQPHGENEPSGRDEASDPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFX3</accession>
    <name>A0A7K2ZFX3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pruA</name>
        <name evidence="10" type="ORF">GT040_18770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000872">
        <property type="protein sequence ID" value="MYW31263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="55"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW31263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="543" mass="58525" checksum="6A7A01D1D578C1C3" modified="2021-04-07" version="1">MDAVTQVPAPVNEPVHSYAPGSPERARLEVKLKELADNPIDLPMTIGGEKRMGGGERVNVVQPHNHQAVIGTFAGATEQDAQDAVDAALAAAPAWRAMAFDDRAAIILRAAELLSGPWRETLAASTMLGQSKTAQQAEIDTPCELVDFWRFNVHYARQILAEQPPANSPGVWNRMDHRPLEGFVYAITPFNFTAIAGNLPTAPALMGNVVVWKPSPTQTHAAVLLMRLLEEAGLPKGVINLVTGDGKAVSEVALNHRDLAGIHFTGSTPTFQHLWKTVGNNIASYRTYPRLVGETGGKDFVVAHPSADRAVLKTALTRGSFEYQGQKCSASSRAYVPASIWNSGFKEEFAAEVDSITMGDVTDLSNFIGAVIDERSFAKNKAAIDRAKSDPACEIVAGGTYDDSVGYFVRPTVIVCSDPENEVFTTEYFGPILAIHVYEDADYDAMLEQMESVSDYALTGSVIAGDRAAAAYTMDKLRYAAGNFYINDKSTGAVVGQQPFGGGRASGTNDKAGAPQNLQRWTLTRAIKETLVAPTEYTYPHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFZ9</accession>
    <name>A0A7K2ZFZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000871">
        <property type="protein sequence ID" value="MYW31260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="10312" checksum="BCEDAB6C22F81719" modified="2021-04-07" version="1">MDVAWYIAGRALPLDALTGHRPPPDERADEREVCLRIARGQEVDSDDLDIAYSAAAGAVGRGVRLTGSLELPRWAHLAGWQPGRNPGHLLRYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG91</accession>
    <name>A0A7K2ZG91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="21008" checksum="CB2CCA3D86EC877B" modified="2021-04-07" version="1">MTMTSSPSPTPSPSPDGERADLLAELADARAALIRTAQGLSDQQIAERPAVSALCLGGLIKHVASTEEGWLNFVVEGPSAMAFDLPEGVTWEDFAAGTAHTYPQWAIDRQNDFQVLPGETLAGILARYEEVAARTEKVVADLPDLSVTHPLPDVPWNEPGAVRSIRRVLIHVIAETTQHAGHADILREAIDGQTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH25</accession>
    <name>A0A7K2ZH25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_20820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000979">
        <property type="protein sequence ID" value="MYW31654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="275" mass="29501" checksum="C4D5189B181F5109" modified="2021-04-07" version="1">MKNLAVVPLALLDVRPWHPGAFGQIGWAVLGFTLASALVYVVNDLADRERDRLHPVKRNRPIASGRVSTTAATVLAGLIAASLTCWAVAGPAWQWWPTALYLALSVAYSQGLKHVPLVDAFIVASGFVLRLVQGALLVGGRISEWLALCVFALCLMLALGKRRHEMTAAGRAHRPALRGYTLAFLDHLVVLVAVLTAVSYVLYLRDDAALAAGASFVTLLSAPCAVFGLARYLQLLLVEEGGANPVHVLFRDRATLVNATLWAVLVSVALLLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH26</accession>
    <name>A0A7K2ZH26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000976">
        <property type="protein sequence ID" value="MYW31642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="150"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="30172" checksum="72AEE37945941EA2" modified="2021-04-07" version="1">MTTHDLPVIAAVDGSTHSRQALDWAAREAARRDLPLLIVHVRPLTRNVDEETGRHEADELLAEAVRRSELVAPASRPSTLAPLDFPAAALVSLSRDASMVVVGSRGLGGFRSLMIGSNSLATASMASCPVVIVQDGRSDEDDRPEDEEAYSDIVAGVAADESSEAVLEFAFATAAARPGARLRIVHGWTMFSSMLAGGPVFDRESAQGSAERGLAEVTSGWQDRYPQVEVVREPVNGSASRTLVTASATAALTVIGRRKGGESLGLGLSPVAQTTVTHALGPVAVVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHG6</accession>
    <name>A0A7K2ZHG6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ORF">GT040_21540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001016">
        <property type="protein sequence ID" value="MYW31790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="52"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="227"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="167"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="233"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="345"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW31790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="489" mass="53248" checksum="684D45AAF391BBC1" modified="2021-04-07" version="1">MNDQIHSGGSDHEHGELGDAEYAEFMELAAQEGFDPEEIEGALGEAGHGPLPVLAIVGRPNVGKSTLVNRIIGRREAVVQDKPGVTRDRVSYEAEWAGRRFKVMDTGGWEQDVLGLDASVAAQAEYAIETADAVVFVVDATVGATDTDEAVVKLLRRAGKPVVLCANKVDGQSGEADATALWSLGLGEPHPVSSLHGRGTGDMLDAVLEALPDAPEQKFGTALGGPRRIALIGRPNVGKSSLLNKVAGEDRVVVNEQAGTTRDPVDELIKLGGITWKFIDTAGIRRRVHLQEGADYYASLRTAAAVEKAEVAVVLIDSSESISVQDQRIITMAVEAGRAIVVAFNKWDTLDEERRYYLEREIETELAQISWAPRVNVSALTGRHMEKLVPAIETAIEGWETRVPTGRLNAFLGEIVASHPHPIRGGKQPRILFGTQAGTKPPRFVLFASGFLEHGYRRFVERRLREEFGFEGTPIHISVRVREKRGRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHI9</accession>
    <name>A0A7K2ZHI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_21165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001002">
        <property type="protein sequence ID" value="MYW31719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="354" mass="37331" checksum="54B19D80F54DB709" modified="2021-04-07" version="1">MIELEGLTKRFGSKVAVDQLTFQVRPGVVTGFLGPNGAGKSTTMRMMLDLDNPTSGTVRIDGKRYNELQEPLKYIGALLDAKSMNGGRSAYNNLLCLAQSNRIPRSRVDEVLGTVGLSAVAKKKSKGFSLGMGQRLGIASALLGDPEILMFDEPVNGLDPEGIHWIRNLMKALAAEGRTIFVSSHLMSEMALTADHLIVIGQGRLLADTSMADFIHENSRSYVRLRSPQQEQLRDVLHQEGFTAVEAEGGVLEIDGATTEALGELAARHQVVLHELSAQRASLEEAFMQMTAGSVEYHAHSGPGGAPPPPGAAAAGAAGAVGAGWGEGWNKPDSDAPDSTTGTEGATGSTNEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHX5</accession>
    <name>A0A7K2ZHX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_22430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029917005" evidence="2">
        <location>
            <begin position="41"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="166"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="30629" checksum="1E401F184E839FD4" modified="2021-04-07" version="1">MPYDDSVPSTRRARPLLAAAALAALCLTTITGCGGPPDTAEGKGADASASPSASASTSPSASAAPGASPTAPLPQGPLTGRTVVIDPGHNPRNREHTEEINEQVDIGTGRKECDTTGTSTDDGYAEARFTLDVSHRLRELLQAQGARVLLTHDDDRPFGPCIDERARIGNEAKADAVVSVHADGSAVGNRGFHVILPAAVKGGGADTSKIVKSSADLGARIAGHFVRTTGSAPSNYIGGGTGLDTRDDLGGLNLSTVPKVFVECGNMRDPKDAALLTDARWRQKAAQGLADGIAAHLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI33</accession>
    <name>A0A7K2ZI33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001065">
        <property type="protein sequence ID" value="MYW32011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="73" mass="7406" checksum="19B0AC42B10C3FA0" modified="2021-04-07" version="1" fragment="single">MPRPTAAQLVYGSATVICTTLALLLLSGTESGIGVGIAAVTALALGLLVAVRLPQSRQPAPARTAHPHRTVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZID7</accession>
    <name>A0A7K2ZID7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001102">
        <property type="protein sequence ID" value="MYW32120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="85" mass="8667" checksum="2D906E8502AA41C6" modified="2021-04-07" version="1" fragment="single">FSKAGFGGAVADFEAAVLAQDAKRSGKAFVRLQETFGQAKEADLLDGGPRLAAVLEQVPPGPRAVVAVLVGACVERGADAERCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ76</accession>
    <name>A0A7K2ZJ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001155">
        <property type="protein sequence ID" value="MYW32384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="33360" checksum="AA547827C029142F" modified="2021-04-07" version="1">MHAITIPEPGGPDALVWAEVPDPVPGDGEVLVEVVSSAVNRADVLQRQGFYNPPPGASPYPGLECAGRIAALGPGVTGWAVGDEVCALLSGGGYAEKVAVPVGQLLPVPDGVDLTTAAALPEVTATVWSNVFMVAHLRPGETLLVHGGSSGIGTMAIQLAKAVGARVAVTAGSPQKLAECAALGADVLIDYREQDFVAELAKATDGAGADVILDIVGAKYLDLNVKALAVNGRLAIIGLQGGVKGELNLGALLTKRAAVTATSLRGRPLGEKASIIAAVREHVWPLIADGVVRPVVDRTVPMADAAEAHRVLESSAHIGKVLLATPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ89</accession>
    <name>A0A7K2ZJ89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lantibiotic dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001159">
        <property type="protein sequence ID" value="MYW32405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="722" mass="79771" checksum="E7BB4D3687FB4ED9" modified="2021-04-07" version="1">DKKQRKIERSLMSYVYRTACKTSPFSTFTGVAPGTLTGSEGLRLRVDEEWRAQARLNVVALGRLADAVIADPSRRADLPVAPASGWGRDDDRVRYVRRWVTAGDDDTAVTFDAVKDRLFFLRRSGTLDRLLSLFEERGGSGLRYGDLVEWLARDQGATREECEQYLGALLDVGMVQVPCLRTEVHDTDPLRAFQGALRGLERPWADRLADRLEEPARCVERFPDASPDERRELLSSLRAELRAVQEEELGADRAKVPQTLLYEDAAAGVETVLDPDAWRELAAGPLAAVERVLSAFDLTLPQRITFAGFFLARYGHGGRCDDLLKLVHDFHEDFFDQYMTFTATRTPYDADGTYVPEVNWLGLERLRSLDTARRTFTTRMAALAEAAGPGAAEVRVDEAFLAEVAAELGGLAPDFAPMSHHLQIADRPGDPLVVLNRSYGGVSFPFSRFTQLFDGLDERLFAGAEAIVPQGAVLAEVTGGPVTSNLNLHGRLTPYEIVCPGERGTLEEQFRISLDDLHLVHDPAADRLVLRSTRLDREVIPVYLGYLVPLALPELPRTLLLLSPTSMAPLNVWAGVPEGAPDADGVTTRPRVRHGSLVLSRRSWSAPATALPPHRPGTNRTEDGWFLDWHAFRRDHGLPDRVFATVSDSGARGATGAKPQYLDFDSPLSLSAFEALIKTPEARVVFREALPDEDALHTVSGHGRHVAELAVETAVPVRRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJR5</accession>
    <name>A0A7K2ZJR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SigB/SigF/SigG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_25320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241107.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001194.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="252"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="307" mass="34414" checksum="CFF0C6A6F9D8A11F" modified="2021-04-07" version="1">MRDETIRPGVVRPAGIPEQQARPHPVDGADGPQGLNVAVEQSQERAGQMSEHGHHDPHDRSGARALFIELRELPDGSAEKAELRNRLVRMHLPLVEHLARRFRNRGEPLDDLTQVATIGLIKSVDRFDPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLSLTTATAELSQQHGRSPTVHELAERLGISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLGSEDEALEGVEYRESLKPLLEDLPPREKRILLLRFFGNMTQSQIAQEVGISQMHVSRLLARTLAQLRERLLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJV9</accession>
    <name>A0A7K2ZJV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF503 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001206">
        <property type="protein sequence ID" value="MYW32623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWKE01001206.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="10782" checksum="F7BAD81433A44FF0" modified="2021-04-07" version="1">MYVGTLSFDLLLGDVRSLKEKRSVVRPIVAELQRKYAVSAAETGGQDLHRRAEIGLAVVSGDTGHLTDVLDRCERLVAARPEVELLSVRRRLHSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK27</accession>
    <name>A0A7K2ZK27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001202">
        <property type="protein sequence ID" value="MYW32599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
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        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13334" checksum="EAD40A906B37EFD1" modified="2021-04-07" version="1">MTLKVDETEQGDWTVLRISGELDLVSSPVVRQSVHEAVAEGQHDVVLDLSEVFFCDSSGVGVLIASRRLMKSCGGRLRLILPARGAEDGSHVNKVLGALGVRRLFDVYPDTVSAVDEACEPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKC0</accession>
    <name>A0A7K2ZKC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoate--protein ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001252">
        <property type="protein sequence ID" value="MYW32791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="128"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="354" mass="38094" checksum="BA698E63C2E29541" modified="2021-04-07" version="1">MHGEYKVPGGKLVVVDLDVEGGALRNVRVAGDFFLEPDEAILAIDAALEGAPANTDTAGLAARIEAALPDSTVMLGLSAEGVAIAVRRALAQATEWSDYDWQLIHDAPQSPALHMALDEVITAEVAAGVRPPTLRVWEWDSPAVIIGSFQSLRNEVDPAGVERHGVNVVRRISGGGAMFAEPSSTITYSLAVPQSLVSGLSFADSYAYLDDWVLEALADMGIKAWYQPLNDIATEVGKIAGAAQKRVVGPDGGPGAVLHHVTMAYDIDADKMLEVLRIGKEKMSDKGTRSAKKRVDPLRRQTGLPRQVVIERMIESFRKRHGLTDGSVTAAELARAEELVRTKFATQEWTARVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKR0</accession>
    <name>A0A7K2ZKR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaX</name>
        <name evidence="7" type="ORF">GT040_18080</name>
        <name evidence="8" type="ORF">GT040_27595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000857">
        <property type="protein sequence ID" value="MYW31132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001296">
        <property type="protein sequence ID" value="MYW32936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="443" mass="46744" checksum="26826F8F1F47477C" modified="2021-04-07" version="1" fragment="single">MSSLALYRRYRPESFAEVIGQEHVTDPLQQALRNNRVNHAYLFSGPRGCGKTTSARILARCLNCEQGPTPTPCGECQSCQDLARNGPGSIDVIEIDAASHGGVDDARDLREKAFFGPASSRYKIYIIDEAHMVTPAGFNALLKVVEEPPEHLKFIFATTEPEKVIGTIRSRTHHYPFRLVPPGTLRSYLADVCGRENSAVADGVLPLVVRAGAGSVRDSMSVMDQLLAGAGDDGVTYAMATSLLGYTDGSLLDSIIDAFAAGDGAAAFEVVDRVIEGGNDPRRFVADLLERLRDLVILAAVPDAGEKGLIDAPADVVERMQAQASVFGAAELSRAADLVNDGLTEMRGATSPRLQVELICARVLLPAAFDDERSMQARLDRLERGASAAAAASFAAPPATAVPMGYVPGPEAHAPQGHAPQAAPVAPAGPDAARAAVRGEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKT2</accession>
    <name>A0A7K2ZKT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_27715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001298">
        <property type="protein sequence ID" value="MYW32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="48"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="333"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="537" mass="57408" checksum="158C818ED2F8C55B" modified="2021-04-07" version="1">MAVPVAFFAVFFAYPVSAIVGRGLKTDGVWQFGRIGDVLSRPEILDVLWFTTWQALASTALTLLIALPGAYVFARFDFPGKQVLRAVVTVPFVLPTVVVGTAFLALLGRGGFLDELWGVRLDTTVWAILLAHVFFNYAVVVRTVGGLWSQLDPRQEEAARVLGAGRFTAWRRVTLPALGPAVAAAALMVFLFTFTSFGVVQILGGPSYSTLEVEVYRQTAQLLDLPTAAVLTMVQFVAVGAILALHAVTVRRRERALKLVDPAQTSRRPHGAGQWALLGGVLLTALLLILLPLGVLVERSFDGPEGYGLGYYEALQTAGGSGSTFLVPPLEAVGNSLQYAFVATLIALVVGGLAAAALTRRAGRLVRGFDALLMLPLGVSAVTVGFGFLITLDKPPLDLRTSWILVPLAQALVGVPFVVRTMLPVLRAVDDRLREAAAVLGASPLRAWREVDLPLVRRAVLVAAGFAFAVSLGEFGATVFIARPDNPTLPVAVARLLGRSGELNYGQAMALSTILMLVCAVSLLLLERIRTDRSGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKY5</accession>
    <name>A0A7K2ZKY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_28020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001304">
        <property type="protein sequence ID" value="MYW33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="499" mass="52414" checksum="FB61F15CA827F971" modified="2021-04-07" version="1">MRRDAGRPDDGPMPSTITGLPLSGPEALTVFGAITLVLARWFPDRFRGPAALAAGALLVGSVTVLVVGELRWQMVPVVAAAAVAAPFALVPMVRRRTGRTPWRARWWLALPGSAVCAALIASGPVSAWALPVPEFPELSGRFPVGTQVLEFSTRPEGDGRDDEGRTLVTQLWYPAGRSAPDAPRMPYLGRTEAESRTVSSALAGYAGVPGFLLDGLPHARSHAVPGAPAAREGGRFPVVLFSPGLGGVRTQNTAWAEELASHGYVVAAVDHPYDSAAVVLADGRTLRTRVSATGDPEEDAARAEGWTRTRAADLRTVLTRLTRMDRGEPDGTLAGRLDTGRVAVTGHSIGGAAALQAARQDRRFDAVIDLDGFPHGPTGGHLGQPVLALTQEIGPGTDPDYLPRLTRVLERGAATNYRLTVPGTAHLTFTDAPLYLPPVSGVVGSLGRTEGHRITAAASLSFLDAALRGAPTDLPTALAAHGEVTVHRPEPHAVPQATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL06</accession>
    <name>A0A7K2ZL06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001296">
        <property type="protein sequence ID" value="MYW32929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="27228" checksum="FF0268F4FB93220D" modified="2021-04-07" version="1">MTDTSPVCRRLVGRTAVVTGAGSGIGLATVRRLAAEGAHVVCADVDEVSGKAAAEEAGGLFVRTDVTDAEEVEALFKAAFDTYGSVDIAFNNAGISPPDDDSILETGLDAWRRVQEVNLTSVFLCCKAAIPYMRAQGRGSIINTASFVARMGAATSQISYTASKGGVLAMSRELGVQFARDGIRVNALCPGPVNTPLLQELFAKDPERAARRLVHIPVGRFAEPTEIAAAVAFLASDDSSFVNATDFLVDGGIAGAYVTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL34</accession>
    <name>A0A7K2ZL34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rlmN</name>
        <name evidence="13" type="ORF">GT040_27725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="WWKE01001298">
        <property type="protein sequence ID" value="MYW32959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030569530.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001298.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="115"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="241"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW32959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="368" mass="40515" checksum="831C223AF3BF0F31" modified="2021-04-07" version="1">MPKPGELTFVAPRGAKKPPRHLADLTPAERKEAVAATGEKPFRAQQLSQHYFARYAHDPEQWTNIPAGSREKLAEALFPDLMSVVRHISCDDDTTRKTLWKLHDGTLVESVLMRYPERVTMCISSQAGCGMNCPFCATGQAGLDRNLSTAEIVHQIVDGMRALRDGEVPGGPARLSNIVFMGMGEPLANYNRVVGAIRRLTDPEPDGLGLSQRGITVSTVGLVPAMLRFSDEGFKCRLAVSLHAPDDELRDTLVPVNTRWNVREVLDAAWEYAEKSGRRISIEYALIRDINDQAWRGDLLGRLLKGKRVHVNLIPLNPTPGSKWTASRPEDEKAFVEAIAAHGVPVTVRDTRGQEIDGACGQLAASER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL54</accession>
    <name>A0A7K2ZL54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="36"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="20969" checksum="8AE8B984A9E8D03E" modified="2021-04-07" version="1">MFDALGAEYERAFAGSAAHHASLDRLLEHLAPGSRVLDVGSGTGVPTARRLAAAGHRVVGIDVSPVMTALAARQVPDAEFRCGDIRELPWADGEFDAVCVYFSLLQMSRGEQSGLLGRMARAVKPGGRLAVATVPVDVADVSAVFMGQPVVVSSFGEEEFASVVAGAGFAVEERHSVLFTPDHPAGAPEPHLFLHGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLB1</accession>
    <name>A0A7K2ZLB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001333">
        <property type="protein sequence ID" value="MYW33135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="304" mass="31480" checksum="5AD7EA9B024A0A0D" modified="2021-04-07" version="1">MKAAALSSYGGPEVLTPSEVPLPEAGPGTVRIRVRAAGVQHFDSRIRGGWAPPFLNLSFPIVPGNEFAGVVDQLGEGVTGFAPGDEVLGYGTLGAYAEYVVAPADQVALKPDSMPWDIAGGFSGNGQGAHMCLEAMGVGAGDTVLINGAAGALGTFSVQLALAWGATTVIGTASEANHAYLRSIGAVPVAYGEGLVERVRALAPEGVDAAMDTVGPEALRASVELVKDRNRIRTMVADDAAKELGVPLLGAGRSVERLIELTGLYERGLIKLHLRETFPLERAADAHRLLDTGHGRGKIVLNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLM1</accession>
    <name>A0A7K2ZLM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03619 family F420-dependent LLM class oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001359">
        <property type="protein sequence ID" value="MYW33257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="30360" checksum="9842CE91668BD075" modified="2021-04-07" version="1">MRIATTIFLTDETVTPVRLARELEQRGFAGLYLPEHTHIPVSRRTPYPAGGDLPREYGRTLDPFVALGQVAAVTERLTLGTGITLVAQHDPVDLAKQVATLDHLSGGRFTLGVGYGWNVEEAADHGVEWSTRRELARDRMALMRALWSAEPASYEGEFGSVQASFAFPKPVQAPRGPVVGPRTLMGGGAGPKLFAAIAEHADGWLPIGGRGLTESVPKLRAAWEEAGRDPKELQVVPYAVLPDAGKLAHYAELGIEEVVLQLPPAGEREVLRVLDGYAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLM3</accession>
    <name>A0A7K2ZLM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_29260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001357">
        <property type="protein sequence ID" value="MYW33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="55"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="38513" checksum="6F481AC97FF8AF15" modified="2021-04-07" version="1">MRWDNLVENNPMTGNSALFAADAVTTRTFDTPEFRGITFHEIRARSILNRVPGASRMPFEWTVNPYRGCSHACVYCFARKTHSYLDLDTGIGFDSQIVVKINAAELLQRELASRHWQGEHIAMGTNVDCYQRAEGRYRLMPGIITALRDRANPFSILTKGTLILRDLELLRQAAEVTEVGVSVSVGFTDRELWRTVEPGTPSPGRRLDVVHALTESGIGCSVLMAPVIPFLGDSPEQLRATVSAIAAAGATSVTPLVLHLRPGAREWYLRWLGLHHPHLVPRYERMYADGAYAPTWYQRRITRQVHELADEFGIGPAHRGEARRITPVRTPEEPEPGPTQLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLW2</accession>
    <name>A0A7K2ZLW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001359">
        <property type="protein sequence ID" value="MYW33259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029736688" evidence="1">
        <location>
            <begin position="28"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="52"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="375" mass="39467" checksum="E76DF45C62096B08" modified="2021-04-07" version="1">MKVRTRSSAIIGALFLAASLTLTTASASADDPSAQVVLTEVARAQGPSAGAAGPDGKVWIAERAGTVRVLGDYGLGDPVLDISDETTTDGERGLLGVAFDPEFAHFYISYTDLEGTSTIDEFAVADGRLQPETRRTVLTQEQPYPNHNGGDIKFGPDGYLYIAFGDGGSGGDPHGNGQNLDTLLGKILRIDPTGGEPYAIPSDNPFVAEDGAKDEIWAYGLRNPWRFSFDAGTGDLLIGDVGQSEWEEIDWAPASSKGGENYGWSSMEGNHPFRGGTEPANHVPPVHEYDRSGLGCSVTGGFVYRGDAIADLAGSYVYSDYCDGTLRTLRIEDGAVTEEGDLGVQGGEVISFVEAGDGELYVLAIGGAVSRLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLY0</accession>
    <name>A0A7K2ZLY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_29615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001370">
        <property type="protein sequence ID" value="MYW33310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015609174.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001370.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="PTHR12704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="239" mass="25477" checksum="0438DDBE715337EF" modified="2021-04-07" version="1">MGRSRRTIPEELLLLALDPTTGTTAQPQSLDLGLAGAQLVELALAGRIAPDGDRIAVVMPRPTGDPTLDSALELLRRRGSPVRAVHWIGGPRLGLRQIYLAHLERCGMVHAVAGQMCGVLPTTRYQATETAISRDIRARLDSAIRTGVPPDPRTAALAALAHAVGLGKHLYPGNEGRSSRSRLRDLIRHDPMGGLVAHAVMDVQNGVAVQPRRTQQAAGVPLQPQAQARRDSMAHTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLY4</accession>
    <name>A0A7K2ZLY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 17" type="primary">hisD</name>
        <name evidence="17" type="ORF">GT040_29930</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 16">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="WWKE01001386">
        <property type="protein sequence ID" value="MYW33371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW33371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="440" mass="46174" checksum="9B51CD22C2680F85" modified="2021-04-07" version="1">MISRIDLRGDTLPEGAALRDLLPRAEFDVEAALETVRPICEDVRHRGSAAVIEWGEKFDGVRIASVRVPAEALTKALDELEPAVRAALEESIRRARLVHREQRRTTHTTQVVPGGTVTEKWVPVERVGLYVPGGRSVYPSSVVMNVVPAQEAGVEGIAVASPPQKDFGGLPHPTILAACALLGVDEVYAAGGAQAVAMFAYGTEDCLPVNLVTGPGNIYVAAAKRLLKGRIGIDAEAGPTEIAILADATADPVHVAADLISQAEHDPMAAAVLVTDSAELAAATEAELAPQVAATKHIKDRIEPALAGRQSAIVLVSSIEDGLKVVDAYGAEHLEIQTADAAAVADRVRNAGAIFVGPWSPVSLGDYCAGSNHVLPTGGCACHSSGLSVQSFLRGIHIVDYTRDALAEVTHHVVTLAEAEDLPAHGAALKARFGWKVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM16</accession>
    <name>A0A7K2ZM16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">GT040_29865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948652.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001382.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZM16"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13771" checksum="9F9C1621AD40D5A0" modified="2021-04-07" version="1">MPTIQQLVRKGRQDKVEKNKTPALEGSPQRRGVCTRVFTTTPKKPNSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM23</accession>
    <name>A0A7K2ZM23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rbsK</name>
        <name evidence="13" type="ORF">GT040_30145</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="WWKE01001391">
        <property type="protein sequence ID" value="MYW33413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="14"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="49"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="226"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW33413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="309" mass="31209" checksum="E6554D52B7B1B385" modified="2021-04-07" version="1">MHDNAAPGDDRYDLLVVGSANADLVIGVERRPAPGETVLGSDLAVHPGGKGANQAVAAARLGARTALLARVGDDDHGRLLLESQRAAGVDTDGVLVGGAPTGVALITVDPSGDNSIVVSPGANGRLTPEDVRAAELLLAAARVVSVQLEIPLDTVEETARGLAPGARLVLNPSPPAPLPDEVLAACDPLVVNEHEARYILGETAGEAPHDWAPALLALGPRSVVITLGAAGALVADSRTDSLDHLVGPKVEAVDTTGAGDAFTAALAWRLGRGDDLREAAAFAVRVGAAAVTSRGAQASFPTQAEVDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMA2</accession>
    <name>A0A7K2ZMA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001401">
        <property type="protein sequence ID" value="MYW33477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514785.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001401.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="65" mass="7179" checksum="0CC9B1E0A96F4C22" modified="2021-04-07" version="1">MKKTVGWAQDGDDWTITVNGTLYRAVERPTDGRVHNYLVRGNDLTAECPSLGHGLGVIRAHESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMD4</accession>
    <name>A0A7K2ZMD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001411">
        <property type="protein sequence ID" value="MYW33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="53" mass="5447" checksum="107E517CBE62C4B4" modified="2021-04-07" version="1" fragment="single">MNSYGTGAEPAVEWSVVESAIGPLLLAATPAGLVSVAFHARPDVRDAALAQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMR0</accession>
    <name>A0A7K2ZMR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001437">
        <property type="protein sequence ID" value="MYW33637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="233" mass="24678" checksum="E56FFCDE49532932" modified="2021-04-07" version="1">MTSTVPASLTRTAEGATLQAVLLDMDGTLVDTEGFWWDVEKEVFADLGHRLEEPWRDVVVGGPMTRSAGYLIDATGADIALDELTVLLNDRFEKRIRHGVPLMPGAGRLLAELAASQIPTALVSASHRRIIDRVLDSVGHHHFALTVAGDEVTRTKPHPEPYLTAAAGFGADPWRCAVIEDTATGVAAAEAAGCRVVAVPSVAPIAPATGRVVVSSLEEVDLAFLRKLVTATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN06</accession>
    <name>A0A7K2ZN06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ectoine/hydroxyectoine ABC transporter permease subunit EhuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ehuC</name>
        <name evidence="8" type="ORF">GT040_31870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001451">
        <property type="protein sequence ID" value="MYW33743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014342">
        <property type="entry name" value="Ectoine_EhuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03004">
        <property type="entry name" value="ectoine_ehuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="26493" checksum="E630D801471F9371" modified="2021-04-07" version="1">MSDFFSLLVEEFPQVRSGLWVTLQATVLGALLAGVLAFALGLMAGSRLLLARGFSRVVVEFFRGTSLYIQLFWLYYAMPLVTGYELAPVACGVVAFGLNFGAYGAEVVRGAINSVPRAQYEAAIALNLSPSRRLWKVILPQAWVQMIPSFTNLLIQLLKATPLLWLLSAADLMTVVQTLRDRTGETLTAYLTLLAVYFVLAYALTMLMNLLERSAKRRLGLATGANSLFKSRSASTAAVGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN45</accession>
    <name>A0A7K2ZN45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_32045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001461">
        <property type="protein sequence ID" value="MYW33776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="186"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="25042" checksum="BDFD6D0A7FD945E3" modified="2021-04-07" version="1">AAHPPAADESRRRTASPGAGTGTGLGAGTGTGTGTPPAVPDPVQPRRRRPFAALAVGAAVAAVVGTAAFAGGLFDRDGSQEEALPEATTSAPDTADEPAAASVAPSPSPSAAPSRTASASPTPSASSASPSPSASPSESSEPSPTASAPATPSPGAPSASATRDAPPPSAAPPAQLAPSSLRRGDQGPQVAVLQNRLAEVWLYHGDADGNFNDRVENAVRVYQSYKAIQGDPAGVYGPETRRALEAETTGQGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN67</accession>
    <name>A0A7K2ZN67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001450">
        <property type="protein sequence ID" value="MYW33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="459" mass="50925" checksum="1DB448D9F242662C" modified="2021-04-07" version="1">MTAPTHQLPADRTPDPAAPVPPQRGHDHGPAGPQSPATDPERWPDIVTRPRTSRARTAVAERIVRRALAKLPLRARLAGVEDIGLGGPLMDIRDPDAFFGRIGASGLIGFGESYMAGEWDAPDLVAVLTVLADNAAELIPAPLQRLRSLWALRKPEAQLNTPEGSRDNISHHYDLSNDLFALFLDETLSYSSAVFRGFPAEQALLPAAQHRKIDRLLDAAGVREGTRLLEIGTGWGELALRAAARGARVTTVTLSAEQRELARTRIREAGFADRVEVRLCDYRQVTGDYDAIVSVEMIEAVGEEFWPVYFRTLDRLLAPGGRVALQAITMPDDRLRASRSTYTWIHKYIFPGGLLPSTEAIERVTTEHTRLRTAQRIGYGAHYAETLRLWRERFTERSAEVDALGFDAVFRRMWTFYLAYSEAGFRSGYLDVQQLLLTREPADRTADEPAGGPTQPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNH1</accession>
    <name>A0A7K2ZNH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="385" mass="41820" checksum="90C7E652A39DD3B0" modified="2021-04-07" version="1">MHILYLLNISNPDRLSADSGWIFADLLAPAFADAGASVTVAAPAAVGDERCGFYLTGVPETKYRARFSYDLDELVELIREERPDVVVANQIEEAAALRIALMEAGSNALLIGYCHYLPFSFTADGQLLLDPAMNDAGMGRPVLLAFAAGLAACDRVLVHSGVAASWVSAAAARMTVNLDDKLRVVPAPRDERLVRDPAHTKPEYSAGSIGVYNHRLYAHYGTEQFVDLARHLAASGTVRLRVMDLFGPRRAGRKSLDDSPDRMRDQLAALPHVQLVSDRGDRLRYKNLLAGARFGIAPFRPGCPWSMSVIDCQGMGLPVIAPRLGWFAEHIDPDLCFTTAAEAVALAERLAADDEFHSLHAERAYASTADFTPALVAARYLEALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNN6</accession>
    <name>A0A7K2ZNN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_33105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001507">
        <property type="protein sequence ID" value="MYW33981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="26720" checksum="19D59298D36FE598" modified="2021-04-07" version="1">MAAGNCLATNDWICGEYLRSRGQELTDATVQHIGITVVSVLIGLAVAFPLALLARRGRGFAGPVLGLTTILYTVPSLAMFSLLLPLFGLSAALVVTGLVLYSLTILVRNILAGLEAVPEEAKEAARGMGYGPGRLLWEVELPLALPALMAGLRIATVSTVALTTVGSLVGKGGLGNLIEDALPSFFKAQVLAASVLCVLLAVTADLLLLGLQRLLTPWTRIRAATGDTGTGAGGADGSGGPGGATEGSGGSGGPAGIPAPAKVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNP4</accession>
    <name>A0A7K2ZNP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001502">
        <property type="protein sequence ID" value="MYW33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="33" mass="3628" checksum="2FBC8BE8BE5DEDC6" modified="2021-04-07" version="1">MLEAFFSALLILVCVGVLAFTVVAVKKLYQGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNW5</accession>
    <name>A0A7K2ZNW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001538">
        <property type="protein sequence ID" value="MYW34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="112" mass="11965" checksum="E9D8853FAE5438CF" modified="2021-04-07" version="1">MLTAALGTEPRVADTEAGIRVEADLPTELTEAEHLAVLAALATADHFGHTLTRTTEFVWAEISREATVTTTDSPDAAYRDLLAHTTTCDGCRAGAVCPTAAKLVRAWRETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNY7</accession>
    <name>A0A7K2ZNY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="109" mass="11485" checksum="58BA1756C64C973F" modified="2021-04-07" version="1" fragment="single">MIQVCLNGRRGADASAAVPLSPEALARSAAEAVAAGATDIHVHPRTPCGQDTLSPRVVAATLTAIRAAVRVPVGVTTGAWAEPDPRRRVERVRAWSVLPDHASVNWHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP75</accession>
    <name>A0A7K2ZP75_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="10" type="ORF">GT040_33940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001549">
        <property type="protein sequence ID" value="MYW34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="162"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="37338" checksum="06E4BA3944981630" modified="2021-04-07" version="1">MKRHLISAADLTRDDAVLILDTAEEMARVADRPIKKLPTLRGRTVVNLFFEDSTRTRISFEAAAKRLSADVINFSAKGSSVSKGESLKDTALTLEAMGADAVVIRHGASGAPYRLATSGWIDGAVVNAGDGTHEHPTQALLDAFTMRRRLVGADAGLGRDLDGRRITIVGDILHSRVARSNVHLLTTLGAYVTLVAPPTLVPVGVEQWPCDVSYSLDDVLAKSDAVMMLRVQRERMNAAYFPTEREYSRRYGLDGQRMAKMPEHAIVMHPGPMVRGMEITAEVADSDRCTVVEQVANGVSIRMAVLYLLLGGSDTALSAPARSEGPARTESPARTEATARTEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPD9</accession>
    <name>A0A7K2ZPD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001565">
        <property type="protein sequence ID" value="MYW34212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="37112" checksum="101DBA8AF2E6A3AE" modified="2021-04-07" version="1">RGSGGGGPAVAHPLRLRLLVLVAFAASAFYVMKLGGPAVFFTSRQEINETVAASGVVTEGSNVGSAFIKGFGQVPALLALLFYTRRLATSYRARRTPSTVLVWVALGALNLVVNNPISNARYWFLTVLMAFVFTAMPSSAAVYRTVLATGVVGALVVFPYADKFRYDDEGQRPAQSASVFEPLVTKDYDQMVMFANTISWVDTRGHTYGRQLTGSALFFVPRAVWSGKPEDTGVRVGQWMGLRMTNLSAPLWTEFWVDFGGGGMAGGMALIGYAAARTDRRYARAVTRAGPGPGSVLAIAAPLIAGYTFILLRGPLLQAAGKLAIAALCLLLIATFREQRAKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPG4</accession>
    <name>A0A7K2ZPG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_34565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001585">
        <property type="protein sequence ID" value="MYW34261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="170"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="28825" checksum="7537905011FD5B74" modified="2021-04-07" version="1">MRETHRPRETAGDSGSGLPQHRPGRAFVHDSGASGSGTPHRSDGRPPHTPRGARRPGPAGHPGTTPPVPGWPASLFLGSLLALFALITWQVAADGPLLRLDERVGESLFRRGPAGLTQLFSDLGGVSVALPVLVCAIAYALWRGARRLPVYAALTMAAVPALVIPLKVATARQGPLTEAVNYYPSGHTATAAVAYGASALLLLAVARPAWLRAWVPPAAAVLLTAATGVGLVLHGYHWPLDVLASWCLGPVLLAPLWWVSREGRLRSGEPRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPR2</accession>
    <name>A0A7K2ZPR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine/betaine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_34925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001594">
        <property type="protein sequence ID" value="MYW34333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029606861" evidence="2">
        <location>
            <begin position="27"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="43"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="36350" checksum="F14FF9E7357FBE64" modified="2021-04-07" version="1">MNRSRTRLLVALASATALLTTAGCGAADMTKQSSPFAAPAGVKTVTLSVQSWVGAQANVAVAEQLLKDELGYRVDLVQTDEVPAWDALSQGRVDAILEDWGHPDQEKLYVDEKKTIVRGGDLGVTGHIGWYVPKYWADKHPDVTDWKNLNKYADELKTAESGGKGQLMDGSPSYVTNDVALVKNLDLDYKVVFAGSEAAQITQIQQFAKEKKPFLSYWYQPQWLFNEVPMVEVKLPEYTDECAAKDPEDIDCAYPTTPLQKFLNADFVERGGDAASFLKKFQWSEKDQNEVSEMIASQRLTPEEAAKRWIDRHPDVWKKWLERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPW9</accession>
    <name>A0A7K2ZPW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001607">
        <property type="protein sequence ID" value="MYW34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="19582" checksum="BE77B10C55E4B617" modified="2021-04-07" version="1">MNPLLRTDRLLLTPYTPADEKEFVALFQDASVSRWMGDGPSTEAEDRALFGRIFSKVYAENRFEVWAVKVGGELVGHAEIKPTEASGGHEIIYALAPGAWGRGLGTELALALVGHGFDSLGLTEVHATVAAGNAASLALLGRIGFVHVRDLQEDDGSTTRLLTCPRGSTPAVRAPGSPETAQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPY2</accession>
    <name>A0A7K2ZPY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hotdog fold thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001623">
        <property type="protein sequence ID" value="MYW34431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="62"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16239" checksum="D52662B662411D8C" modified="2021-04-07" version="1">MGEHTAPLFPQEVIDEYAALGVDLPALFSAGHLGERMGVTIVEAAADRVVGTMPVEGNTQPYGLLHGGASAVLAETLGSIGSMLHGGATKIAVGVDLNCTHHRSARSGLVTGVATPVHRGRSTATYEIVITDEQDKRVCTARLTCLLRDTPRPDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQF5</accession>
    <name>A0A7K2ZQF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_36330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001648">
        <property type="protein sequence ID" value="MYW34601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="314" mass="33824" checksum="D85A743B07717817" modified="2021-04-07" version="1">MADTSTPSGTAGSWALEARGLGKRYFRGWALRDCSFRIPAGRICGLVGPNGAGKSTLLGLATRQVQRTTGELRIFGTPVDDSAVLPRFAFLGQDKPLFKRFTVADTLRMGAELNPGWDAAAAERIVRSGNVPMHARIGTLSGGQRTRVAFALAFGKRPDLLLLDEPMSDLDPLARDEMSTLLMAEAVERGTTVVMSSHMLTELEDMCDYLLVVAEGRIRMAGDADALVPAHTLVTGVTRDGALPAELDRHTVVESRVQGRQFQAMIRPKGPLSADWETVEPSLEEVLLAHLRSPDAPSLYTQGARVDAEGTQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR93</accession>
    <name>A0A7K2ZR93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001722">
        <property type="protein sequence ID" value="MYW34894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513243.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001722.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="11676" checksum="964B134AF8F81FE4" modified="2021-04-07" version="1">MYRQGDVLIVALEESAVPAPFLKASGELRDGRGRLVLALGEVTGHAHAVQGPGRLIREAGPFGPMLLHLPEGGRVVHEEHATIALPQGWFRVVRQREYAPGAIRIVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRS6</accession>
    <name>A0A7K2ZRS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001772">
        <property type="protein sequence ID" value="MYW35091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="12596" checksum="8A5B00EB84A69CFC" modified="2021-04-07" version="1">MADRAIPGIDPQAAPGGPGCAGCLAGDGPGWWFHLCRRAACGRTGCCDSSPYQHATRHFRTAGHPFITSCEPGEEWFCNNGTEQFSEGPQLAPPTSHPADQPVPGPAGAVPEDWQQRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS44</accession>
    <name>A0A7K2ZS44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetase</fullName>
            <ecNumber evidence="2">3.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fahA</name>
        <name evidence="2" type="ORF">GT040_39525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001792">
        <property type="protein sequence ID" value="MYW35204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="334" mass="36068" checksum="E17276FC52A93A19" modified="2021-04-07" version="1">RTAWRDVRRALTAWLTVPGHRADIEPLLHPVDAVTLHLPYEVADYVDFYASEHHATNVGKIFRPDGDALTPNWKHLPIGYHGRSGTVVVSGTDVVRPSGQRKAPTDPAPVFGPSVKLDIEAEVGFVVGVPSAHGTPVPLADFREHVFGLSLLNDWSARDLQAWEYVPLGPFLGKSFATSVSAWVTPLEALDAARTAPPTRDVPLLPYLDDANEEEHGGFDIRITVEINGQVVAEPPFASMYWTAAQQLAHMTVNGASLRTGDLYGSGTVSGPETTQRGSLLELTWNGRDALELPEGKRTFLEDGDTVTLTAWAPGPHGTRVGLGDVTGRIVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS65</accession>
    <name>A0A7K2ZS65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">serS</name>
        <name evidence="10" type="ORF">GT040_38780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001770">
        <property type="protein sequence ID" value="MYW35069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513723.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001770.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="139"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW35069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="425" mass="47042" checksum="BA0AD74997E0515A" modified="2021-04-07" version="1">MIDLRLLREDPDRVRASQRARGEDVALVDALLSADELRRSSGVRFDELRSEQKQLGKLIPKATPEERAELLKKADQLKADVKAADAAQDEADAEAKRLLLQLGNIVHEDVPVGGEEDFVVLETHGTIRDFGAEGFEPKDHLELGEALGAIDMERGAKVSGSRFYYLTGVGALLELALVNAAIAQATEAGFIPMLTPALVRPRAMEGTGFLGQAAENVYHLEKDDYYLVGTSEVPLAAYHMDEIVEADKLPLRYAGFSPCFRREAGTYGKDTRGIFRVHQFDKVEMFSYVDPADAEAEHRRLLEWEKQWLTGLELPFQVIDVATGDLGASASRKFDCEAWIPTQGKYRELTSASNCDSFQARRLSVRMREGKKVQPLATLNGTLCAVPRTIVALLENHQLPDGSVRVPEVLRPYLGGREVLEPVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSG0</accession>
    <name>A0A7K2ZSG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001781">
        <property type="protein sequence ID" value="MYW35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="20287" checksum="0E27BBFF2A2FB23D" modified="2021-04-07" version="1">MAEVVLFHHAQGLTPGVETFAAELRRAGHTVHVPDLYEGHVFETLEEGIAYASRTGFSAIAERGVTAADRLGGGLVYAGFSLGVVPAQRLAQTREDAEGALLFHSCLPVTEFGEAWPTGLPVQVHGMDGDPFFAGDGDLDAAKELTTGTEGAELFVYSGDQHLFADSSLPSYVPAAADLLLRRAVEFLDGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSU1</accession>
    <name>A0A7K2ZSU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_40650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001847">
        <property type="protein sequence ID" value="MYW35413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="188" mass="20676" checksum="EBAF99130EDFC3E5" modified="2021-04-07" version="1">MTTPVCTGASRAASATAAGHSTYAPYASFSSYVRARGPVLLRTARSLTANPCDAEDLLQTALAKTYVAWERIEDHRALDGYVRRALLNTRTSQWRKRKVDEFACEELPEQGGAAAPDPAEQQSLHDAMWRAVLKLPDRQRAMVVLRYYEDLSEAQTAEVLGVSIGTVKSAVSRALGKLREDPELTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZT36</accession>
    <name>A0A7K2ZT36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001838">
        <property type="protein sequence ID" value="MYW35369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="750" mass="79307" checksum="45CCFFB63C3FC912" modified="2021-04-07" version="1" fragment="single">MNADPPIPPTPLPVALTGRSALLDELGPVLGRRPSVVVITGEAGVGKSRLVRELLTRTRSSGTPTLAARCREPDASLPYAPLPDASLPYAPPPDAAFPYTPLPYAPIPYAPLIEALSRCRPRPEDLPPVTGALRGLLPELADLLPPAPPPADDPLAGQHRVLRALCALTASLGRVVLAVEDLQWADGSTASFLHAIVADPPPELGLVLTARRHTLPHTGTDGGDGLPFPLRPPAHVVVAERHLAPLSVAEAGVMAAGLLGARAVPEEFAERLHRWTGGLPYVVEEVLREWSDSTECPVGTAGQPEPPLPASVRRVVVERLRHLPSDARRVVSAAAVLGDPAPVHLLGAVAGLAEQETRRALAAALKEGVVRAGDGTYAFPYELARRAAYEAVAEPERPVLHLRAARTLTRCTGPLPLVRVAEHYRCAGLRTQAVRYLEAAADRAALGGDAGTATDRYLDALRGGPSAVVRDRVALKLARVALNARTGPQVPAALREVLDRSSLGPGPSGEIRLLLGLLLRNQSGSGLEALEEIARAVPDLLAVSTGQAARALAIIAIPSLKGWPVGEHRRLLAEAERLLPQVDEEDLRSAVLANRATALALMGDPSAWDAVADLPEAITVEAAARVHANLAGAAIALGHPERARAFQNRAWQAVRTNQAPYLEAFVETTDMLAAFTSGRWAGLLERAEHAEQQYQDVPDFHAEALLVCGLLRLHTKGQTDVARRLLDRAVGTTALDTGIVLTSAAAAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z667</accession>
    <name>A0A7K2Z667_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4'-phosphopantetheinyl transferase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_00720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000021">
        <property type="protein sequence ID" value="MYW27828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009366">
        <property type="term" value="C:enterobactin synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009239">
        <property type="term" value="P:enterobactin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003542">
        <property type="entry name" value="Enbac_synth_compD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38096">
        <property type="entry name" value="PTHR38096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01399">
        <property type="entry name" value="ENTSNTHTASED"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4PPT_N" evidence="3">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="102"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW27828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="24737" checksum="9A32F915ABEEC94C" modified="2021-04-07" version="1">MIESLLPAYVSCAATREESVPDGTLFPEEEELVARSVPKRRNDFATARACARRAMGRLGLEPVAVLHGKRGMPLWPEGIVGSLTHCDGFRAAALARDADVLSLGVDAEPHAPLPEGVGELVVRPSERERFAGPPAGEAGAIHWDRLLFSAKESVFKTWYPLTLTELDFDEADLTFHRDDDRAAFGTFTARLLRTDPALPPVLDGKWRVEDGIVATAVLLRPGWRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z676</accession>
    <name>A0A7K2Z676_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="2">2.4.2.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000030">
        <property type="protein sequence ID" value="MYW27850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="29651" checksum="38CDB2DD8ACD1D39" modified="2021-04-07" version="1" fragment="single">MVNAHTDTSYGTDIAGTAPGAEIGVIGGSGFYSFLEDVTEVSVDTPYGKPSDSVFLGEIGGRRVAFLPRHGRGHHLPPHRINYRANLWALRSVGVRQVLGPCAVGGLRPEFGPGTLLVPDQLVDRTKARVQTYYDGETRADGTVPNVVHLGFADPYCPEGRKAALAAARGRGWEPVDGGTLVVVEGPRFSTRAESRWHAAMGWSVVGMTGHPEAVLARELGLCYTTMTLVTDLDAGAEAGEGVSHEEVLQVFAANVDRLRSVLFDAVGGLPDAGARDCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6B1</accession>
    <name>A0A7K2Z6B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000052">
        <property type="protein sequence ID" value="MYW27890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="10821" checksum="628C4FCA09AA5668" modified="2021-04-07" version="1" fragment="single">MRPEDTRGTGGGGLPVPMAWLYTEYVADELLRTGDLMEPTTLEFRAGRDALALTMFLSGLLREAPLSGTLSEARADELRVLTAYGAAWRSWVCERLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6P6</accession>
    <name>A0A7K2Z6P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000071">
        <property type="protein sequence ID" value="MYW28019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027273">
        <property type="entry name" value="Neocarzinostatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49319">
        <property type="entry name" value="SSF49319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029856582" evidence="1">
        <location>
            <begin position="34"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="17612" checksum="36791028708F4325" modified="2021-04-07" version="1">MSAVPSTRTVARTGLAVLSAAALALSLASPAAAATGTRTITDGGTTYNLSLTAPDTATATGQNITVTGSGYNPGQGVYVSLCVVDGAQGANKPSPCLGGQDESGTTGASHWVSSLGGGLPNTSPFGAGGTFSVQIHVKADLGGGNICGDTVECAIVTRADHTDTNDRKYDVHTPIDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6U0</accession>
    <name>A0A7K2Z6U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4173 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_01810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000077">
        <property type="protein sequence ID" value="MYW28038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025231">
        <property type="entry name" value="DUF4173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13777">
        <property type="entry name" value="DUF4173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4173" evidence="3">
        <location>
            <begin position="165"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="432" mass="46416" checksum="71BA0219F570D484" modified="2021-04-07" version="1">ALLAVPALRDAGWPTFLAVVSAFALGSLALHGSRSWLGVLIGSVGIVDSVAAGVRWGWRGVRERADDSRGRWGTAVRTTAVAVGLLVVFGTLFASADAAFADLLGRLTPDVSIVDGPLRTFLFLVGLVGALAAARTAAAPVRWDGLTVKAGKPRGRTEWALPLIVLDLLFAAFITLQLVVLLGGYDKVREKTGLDHAEYARQGFWQLLWATLLTLVVIALALRWAPRGGSRDRTLVRAVLGTLCVLTLVVVASALRRMDLYVAEYGLTRLRISVAAMELWLGIVFVLILAAGVFGARFLPRAIAVSAAAAVLAFGAVSPDAVVAEQNVQRFEDDRTSIDIDYLKDLSADAVPALDKLPEPQRSCALRVIQSDLRGSDSPWYATSLGEARAGEILRERPATADHRTCYGLGTDGVREGERDGYEQDHDDYDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z792</accession>
    <name>A0A7K2Z792_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000111">
        <property type="protein sequence ID" value="MYW28185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="16430" checksum="F959025D24B405E9" modified="2021-04-07" version="1">MTWEMTTRTTSPRQKRNLATIDVALARVQAAVDETGQSRPVHANFTALHAVRAPAACDRVGFGEALTSLRFRHRETSKGGGRPGSLLPLLPLALAALACRREDLLPPADTGYLPQALVTGFAVPAPSGSVPGAVGRAAMIAALASGAVLSERPEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7D0</accession>
    <name>A0A7K2Z7D0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000116">
        <property type="protein sequence ID" value="MYW28215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="8282" checksum="1E48B5AB804C7CFC" modified="2021-04-07" version="1">MVVAEVDHVTPLARGGVHEWFNLAPACARCNRVKGDRDMSDWLHVLAGQLDTEREVTATERDLLPARHVHTPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7I8</accession>
    <name>A0A7K2Z7I8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_03055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="WWKE01000143">
        <property type="protein sequence ID" value="MYW28278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="428"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW28278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="470" mass="51698" checksum="320805D710F0B81B" modified="2021-04-07" version="1">MNLATTPQRILRPTAVRGLPAGFRWGVATSSYQIEGAATEDGRTPSIWDTFCRVPGAVEGGENGDVACDHYHRMPEDVELIAGLGVDTYRFSLAWPRIQPGGRGPANSKGLDFYKRLVDELQGRGVTPWITLYHWDLPQELEDAGGWPARDTALRFAEYALLAYEALGDRVEHWTTLNEPWCSAMLGYAYGVHAPGRKDFGASMRAVHHLLLGHGLAARAMREAAGSNPLELGITLNLGTATPETPSEADRDACRRADGMGTRLYLDPIVHGRYPEDVVADLAAQNVELPLEEGDLAVISTPLDVLGVNFYRGMQFSGTTEDGSTADAEGLPVVRVVERDLPRTAMDWEITPTELTDLLVRLENDYGLPTVITENGAAFDDTVAADGSVPDADRTAYLADHIDAVAAARDRGADVRGYFAWSLMDNFEWAYGYDKRFGIVRVDYATQTRTLKDSAKWYRDTILLTRGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7M2</accession>
    <name>A0A7K2Z7M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="9416" checksum="840FA115CCF4687B" modified="2021-04-07" version="1">MRRLLNYLNDLTLRVYVRLQILAATEPVRLRSVLTSAVLALAFFVPSLAQPDVTDHLVSFGAVALPILVGESARNKVSPTDPADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7N8</accession>
    <name>A0A7K2Z7N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="25622" checksum="D992FD3B350E9248" modified="2021-04-07" version="1">MALIATLRALGRPLHLDLFCCQGGASKGYADAGFTVLGVDIDPQPRYVHPGQFVQADAVEFVRRYGHLFDSASASPPCQLYSKTHRIQKNDHPDLIGPTRKALEETGLPWVIENVMDAAPELRSPRMLCGAMFGIETYRHRLFEPGGGFSFVPPEHPQHVARTTKMGRPVKPGEYMHVVGNFTGVDLARDVMGMPWANRDGLREAIPPAYTEWIGERLMAHVMGDEMREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7T5</accession>
    <name>A0A7K2Z7T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000158">
        <property type="protein sequence ID" value="MYW28414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="257" mass="26977" checksum="BE0084AFA6042479" modified="2021-04-07" version="1">MAEKNSAGGGDLPPSIEAAWGLRERPVKGPKPGLSLERIVAAAVAVAASEGIAAVSMGRVAKEVGASTMSLYRYVSAKDELYVLMQEAAIGPPDPLAALAAGAGWREALTEWAAGQREQFLANLWVLRIPIGGPPATPNSLAWWEQGLQALEGSGLSEGDKISVILLISNFVRSEALLMSDLAAAVAARGVSPEEVVAGHERTLRRLVDPVRHPAIHRLLDSGVMSEPDDPDSEFTFGLTTLLDGVEALIRSTAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Z1</accession>
    <name>A0A7K2Z7Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000161">
        <property type="protein sequence ID" value="MYW28428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14222" checksum="38BA0826A9B39018" modified="2021-04-07" version="1">GPRVAELEVLLGRVRLSLAPLVHPLSPLKARKARARQVLALLDDCVREVRGLASIAADPAASHDARLSAACSRVEEAVEELLRQESREERGAGRAGVQSGAAVDHPALAHLHGLERALADLATPLHSPPRAPIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8L2</accession>
    <name>A0A7K2Z8L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000217">
        <property type="protein sequence ID" value="MYW28635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="109" mass="10637" checksum="0479EB0A5B3B5997" modified="2021-04-07" version="1">VSGLHLWAIAVLLGAPPLLSLPVCVGGFALATVAGSLAFVLPDGWGARELVLLGPLSAVMPLSAAAAAVIASRLVCVISEVAATGGALLWARAAGPLPTPRPALPEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8P6</accession>
    <name>A0A7K2Z8P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000247">
        <property type="protein sequence ID" value="MYW28716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514886.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000247.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="339" mass="36887" checksum="C02DEA01C5C11F4F" modified="2021-04-07" version="1">MGVSLKDVAQRAGVSIKTVSNVVNNYQHVTPKMRAKVQQAIDELGYRPNLTARHLRKGRTGIIALAVPEFGNPYFAELAGEVVDAAARHDYTVLVDHTGGLREKELLVSQGFRSHVIDGLILSPIHLETEDLMARTETAPLVLLGEREYEAPYDHIAIDNVAAAREAVAHLIALGHRRIAFLGSRTGQERQPAHLRLRGWREELAASGITPDESLVVVTDGYGREDGAAAMASLLDRGEQPDAVFAYNDMIAIGAMRTITERGLTIPGDIAVVGFDDIEESRYGTTTLTTIAPDKAAIARLAVDSLVERLAGTPVAEPRRPRPGYRLVVRESTAPRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Q6</accession>
    <name>A0A7K2Z8Q6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ORF">GT040_05485</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000249">
        <property type="protein sequence ID" value="MYW28734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015611061.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000249.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW28734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13442" checksum="A9DB273B51779877" modified="2021-04-07" version="1">MLQPPHQPLQVAAVPAQRTPAREDEAGPWHSEAVCRRDEAGLFFAPSKEPTAARLAREEAAKRVCARCPVMVACREHALMQPEPYGVWGGLTAAERRVALARRRRRDIELTAAAPAERIAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8T9</accession>
    <name>A0A7K2Z8T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">urtA</name>
        <name evidence="2" type="ORF">GT040_05525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000250">
        <property type="protein sequence ID" value="MYW28742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029777903" evidence="1">
        <location>
            <begin position="38"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="415" mass="44070" checksum="D528055E09819E73" modified="2021-04-07" version="1">MSGLITRRGLLAGISALGAGAALSACGAKTGSDTSKAAGAKADTSGDTVRVGLLNSLSGTMAISEVTVHNALLLAVKEINAAGGVLGKRLKPVSQDGASDWPTFAEKAQALITDSKVVATFGCWTSASRKAVKPVFERNKSLLFYPVQYEGLEQSPYIFYSGATTNQQIVPALDYLKKQGLTKLYLVGSDYVFPRTANKIIKTYAKANGMEVLGEDYAPLGSTEFATIVNKVRSAGADAVFNTLNGDSNVAFFKEYKSAGLTAKKLPVLSVSIAEEEVKSIGTQYLEGQLTAWNYYQTTPGAANEKFVSAYRAAYGKDKPTSDPMEAAYISVHLWKAMVEKAGSFDVEKVKAASDGIEFDAPEGKVTVDGATQHVHKTARIGKVTANGLIEEVWNSGGPIKPDPYLKGYDWAADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8V1</accession>
    <name>A0A7K2Z8V1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rpsC</name>
        <name evidence="12" type="ORF">GT040_05735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000252">
        <property type="protein sequence ID" value="MYW28784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW28784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="26749" checksum="71C2ABB02FB1D5FD" modified="2021-04-07" version="1" fragment="single">MGQKVNPHGFRLGITTDFKSRWYADKLYKDYVKEDVAIRRMMTKGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRGELEKLTGKQVQLNILEVKNPEVDAQLVAQAVAEQLSSRVSFRRAMRKSMQSSMKAGAKGIKIQCGGRLGGAEMSRSEFYREGRVPLHTLRANVDYGFFEAKTTFGRIGVKVWIYKGDVKNIAEVRAENAAARAGNRPARGGTDRPAGRGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z994</accession>
    <name>A0A7K2Z994_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="5">4.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-thionase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Serine sulfhydrase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GT040_06355</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homocysteine + L-serine = H2O + L,L-cystathionine</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000295">
        <property type="protein sequence ID" value="MYW28903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="336"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="409"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW28903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="468" mass="49624" checksum="0643E40617334750" modified="2021-04-07" version="1">MQFHDSLITLVGNTPLVRLRNVTAGIQATVLAKVEYFNPGGSVKDRIALRMIEAAEQSGELKPGGTIIEPTSGNTGVGLAIVAQQKGYKCIFVCPDKVSTDKINVLRAYGAEVVVCPSAVDPEHPDSYYNVSDRLVAETPGSWKPDQYSNPNNPRSHYETTGPELWEQTEGKITHFVAGVGTGGTITGTGRYLKEISKGAVQVIGTDPEGSVYSGGSGRPYLVEGVGEDFWPSAYDAEVTDEIVAVSDKDTFQMTRRLAKEEGLLVGGSCGMAVVGALEVARRLGPDDVVVVLLPDSGRGYLSKIFNDEWMADYGFLEDTSSSPQVSAVLNFKEGPLPSLVHMHPDETVGQAIDVLREYGVSQMPIVKPGAGHPDVMAAEVIGSVVERQLLDALFTQRASLSDPLEKHMSAPLPQVGSGEPVEDLMAALSGADGADAAIVLVEGKPKGVVSRQDVLAFLAKDAGSAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAF6</accession>
    <name>A0A7K2ZAF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hyaluronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000402">
        <property type="protein sequence ID" value="MYW29336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="254"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="391" mass="41576" checksum="2012AEA1873971E6" modified="2021-04-07" version="1">QLALEPLRQEIAAAKATVGKGVLDPFLDRAERTADGWNGVDRSSGRVTKDAHSYTVRLDRARPVEAVTALAEPGPDLTGAVVEAHVPGEGWRALGQLSPTGWTQTAAKGLRADAVRVTVPEAARTTPPSYLSPSLPPAPAIPAGTPKLRALVPWFGDEPDAVLDLAHGETDAEIGGEPQRVAARLAGRRPAEVKGKLTAKAPKGIEVRVPKQTTVPRGSRTEVPVDITVPADTPAGEYEVPLTFGGQESTLTVRAFPRTGGPDLVRTATASSSADETPDFPASAASDGDPETRWSSPAEDGAWWQAELPQPVRLGQVVLSWQDAYAAGYRIQTSADGRTWRTAATVREGRGGRESVRMDAKDTRFIRVQGDARATQYGYSLWSVEAYAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAH2</accession>
    <name>A0A7K2ZAH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000385">
        <property type="protein sequence ID" value="MYW29302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="63"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="415" mass="43344" checksum="346334290232E641" modified="2021-04-07" version="1">MASHNPNLDLVIRNGRLIDGTGTAPVPSATVHLADGRITWVGPESSAPRPPAATTVIDARDGTILPGFIDCHVHLAAPGGEMSRVALAAMPASLRTYLTTPRLLATLMSGVTTARDLAGLDAGFRQAVDRGLVTGPRLQVAVAMMSPTGGHGDFRPPTDSGPVEPSVSRLADGVAECRREARNLLRQGADLIKIAATGGVGSPTDQPDDEGFTEEEIRAVVEVARAHRGKRVAAHAQGRGGILNALRAGVDSIEHGYQLDEEIIDLMLAQGTYLVPTLSTATHTFDPATTPPWTLAKKKQWQEHALASVPRAIERGVKIAMGTDCGIAAHGNNLRELGFLVDHGMAPMDAILAGTSVAAELLGLASEIGTLEAGKRADLVIAACDPLADIHQLGDATNIPVVVKDGAVCKNTLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAP7</accession>
    <name>A0A7K2ZAP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_09020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000412">
        <property type="protein sequence ID" value="MYW29414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029476434" evidence="4">
        <location>
            <begin position="35"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="94"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="22441" checksum="948B367E6DBC2332" modified="2021-04-07" version="1">MTHTRTRTRPAGLSAASFLVVASLTLFGATPALADDGPSVPPGTEAQSVPPVEVDANDPDLKMPDGGTLGPAKVLDIVQVVEDLGGEERREDSNADIKFALQAEVLFGKDSAKLSSAANARIAAIADEIKKQNATKVRVFGFTDNLGSSAHGDVLSKKRADAVHGVLSKALGPTITYEIRGYGEQYPIASNSNEEGRKKNRRVEVSFPRGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAZ3</accession>
    <name>A0A7K2ZAZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000449">
        <property type="protein sequence ID" value="MYW29537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="399" mass="40702" checksum="3865352E1E65929B" modified="2021-04-07" version="1">METPGSQTSLHRANLERVVRAVRMAGSLTQAEIARSTGLSAATVSNIVRELKDGGTVEVTPTSAGGRRARSVSLSGDAGIVIGVDFGHTHLRVAVGNLAHQVLAEESEPLDVDASSAEGFDRAEVLVNRLIEATGIGPDKIIGVGLGVPGPIDVESGTLGSTSILPGWTGINPSEELSGRLGVPVYVDNDANLGALGELVWGSGRGVKDLAYIKVASGVGAGLVIDGTIYRGPGGTAGEIGHITLDESGPVCRCGNRGCLETFTAARYVLPLLQSSHGPGLTMERVVQLAREGDPGCRRVIGDVGRHIGSGVANLCNLLNPSRVVLGGSLAEAGELVLGPIRDSVSRYAIPSAARQLSVLPGALGGRAEVLGALALVLSEMGDSTLLESTLPAATPAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB38</accession>
    <name>A0A7K2ZB38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000449">
        <property type="protein sequence ID" value="MYW29538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029628594" evidence="1">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="77"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="20716" checksum="5B60B92AE752F079" modified="2021-04-07" version="1" fragment="single">MNTRMRRAAVAVAATTMAISLAACGSAKESGDKAEQGSEKKGNDLKIGLLLPENQTARYEKFDRPIIEKKIGELTDGKAKVIYANAKQDANTQSQQVDTMITNKVDALIVGSVDSKAIANSVKKAKDAGIPVVAFDRLAEGPIDAYTSFDNEEVGRAQGKALLEALGDKADGGTIVMMNGAITDPNAALFKKGAKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB80</accession>
    <name>A0A7K2ZB80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000464">
        <property type="protein sequence ID" value="MYW29631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="246"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="405" mass="44132" checksum="187EB915C6DBA54F" modified="2021-04-07" version="1">MSTAAPNQWKTLPAPDSPQAWIGRATEVAALLATDAAARDKEAATPYTEIQLLKDSGLVTLLGPAGHGGGGQDWTTAYRVIREVAKADGSIGQLLGYHYLWNWAARLVGTREQWEHVEAEAVRQTWFFGGAVNPRDSDVVVTEDGDDLVFTGAKTFSTGSKVSDVTVLEGVLEGTDQHIFAIVPSDSEGLVFHDDWDNIGQRLTESGGVTIDGVRTPWASAAGYVDKEFRPRVYNTLNVPTIQLVFISFYLGIAAGALETAATYTRTKARSWLHGGYEQAVDEPYVIDTYGDLTAKLWAVEALADAVAGEGQKLHDAPDEVTEQTRGEFEVRVAAAKARATDVALEVTSRIFEVTGARATASAEGLDRFWRNVRTHTLHDPVAYKRREVGRHVLTGELPEPTWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBL7</accession>
    <name>A0A7K2ZBL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_10670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000490">
        <property type="protein sequence ID" value="MYW29729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="60"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="455" mass="48573" checksum="CAD0FCED2ABD6242" modified="2021-04-07" version="1">MEPDLFTAAAEDRQEKDPSSSPLAVRMRPRVLDEVVGQQHLLKPGSPLRRLVEGSGGPAGASSVILWGPPGTGKTTLAYVVSKATNKRFVELSAITAGVKEVRAVIESARRATGGFGKETVLFLDEIHRFSKAQQDSLLPAVENRWVTLIAATTENPYFSIISPLLSRSLLLTLEPLTDDDLRDLLRRALTDERGLGGAVTLPEDAEAHLLRIAGGDARRALTALEAAAGAALATHEAEITLETVEATVDRAAVKYDRDGDQHYDVASALIKSIRGSDVDAALHYLARMIEAGEDPRFIARRLMISASEDIGLADHTALPTAVAAAQAVAMIGFPEAALTLSHATIALALAPKSNAATLAISAAQEDVRKGLAGPVPAHLRDGHYKGAAKLGHAQGYVYPHDVQGGIAAQQYAPDEVRDRLYYTPTRHGAEARYADVVERVRERLGRNPQGADPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBR2</accession>
    <name>A0A7K2ZBR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">galE</name>
        <name evidence="9" type="ORF">GT040_11075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000501">
        <property type="protein sequence ID" value="MYW29810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="8">
        <location>
            <begin position="4"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="332" mass="35510" checksum="25398BFB0E869F8B" modified="2021-04-07" version="1">MTWLITGGAGYIGAHVARAMVAAGERVVVLDDRSSGIVDRLPEAVTLVEGSTGDRELLDRVLGEHAVSGVVHLAAKKQVGESVEKPLLYYRENIAGLTVLLEAVVAAGVRRFLFSSSAAVYGVPDVDLITEETPCLPINPYGETKLAGEWLVRATGRAHGISTACLRYFNVAGSAGPELADTGVFNIVPMVFDRLTRGEAPRIFGDDYPTPDGTCIRDYIHVADLADAHLAVARKLGVRGGGDLTLNVGRGEGVSVRELIDVIREVSGHPVEPVVEARRPGDAAKAVASDARMVRELGWTARRDVRSMVESAWEGWCLRHPEACTDARGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC17</accession>
    <name>A0A7K2ZC17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HdeD family acid-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000501">
        <property type="protein sequence ID" value="MYW29815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="23269" checksum="B3EFDB2F1CAC9C19" modified="2021-04-07" version="1">MNGPTAEGGKHGPGTQGGKRGPTAEGRKLSRSFSWLALLGTLLVIAGIVGLIYTGVATLTSMLLFGWLLLIGGVVALAHAIQSRGTNYFWLGVVVAALNLAAGVVVIRHPEGTAEALTMFAALLFLTGGVFRLVGSVVVRGPQMGWTLLQGAFGLLLGLLVLFDWPHSSLYVLGVFFSLALLFDGLGLIAIGVGGRRIVSMVSDRLEAPGPATDSPPKAPGNGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCC5</accession>
    <name>A0A7K2ZCC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000547">
        <property type="protein sequence ID" value="MYW29958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="6556" checksum="F4716141366EC82B" modified="2021-04-07" version="1">MGKSTDMARAKARRLKGMKKESDGIALGDERMKAEGRQEQDAARREEERARALRGASGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCF8</accession>
    <name>A0A7K2ZCF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AfsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000567">
        <property type="protein sequence ID" value="MYW30051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="172" mass="17761" checksum="4232EC9D42123527" modified="2021-04-07" version="1">LGALADGEALELLGKLIGPGRLRTDPAAALRIVRACGALPLAVGVGGMRLAVLRHLPLAEYADRLGDPSAALDELVAGDISVRLRMASGWQDLSADDRRALGRLAGPAQEGGFTLDGAMEALGCGERAAIRTVESLIDAGAVTSPAGEVTAHAALYEVPRLLCLYAREREVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCK7</accession>
    <name>A0A7K2ZCK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000596">
        <property type="protein sequence ID" value="MYW30090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041586">
        <property type="entry name" value="PsrA_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17939">
        <property type="entry name" value="TetR_C_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22456" checksum="661069EA8DD16CBA" modified="2021-04-07" version="1">MVLPDTRSNVLDAAERLFAENGYRGTSVRAITNLAGANLAAVAYHFGSKAELMAAVARRVAGPINRAQHARLDEALAKNADPDVADLVEAFVGPLFDEMPADDADGARTSRLIMTILSDPAEEARSWTGPDEAAVRERFLSAFTRALPGVAPQELWFRLRGVLAVTAVDRVEVHNQPTPGCSTAAGEDAKRWAITFLTAAMSAPATETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCV6</accession>
    <name>A0A7K2ZCV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000606">
        <property type="protein sequence ID" value="MYW30190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="8271" checksum="9C9B64DB14C9F4A2" modified="2021-04-07" version="1">MGWTHDFTDEARNRRSTATAGASTHEGGGPLGRVHEVHDLHHHRLGNHRLGISRILRRRARWVSARLRHPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD29</accession>
    <name>A0A7K2ZD29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000613">
        <property type="protein sequence ID" value="MYW30232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="26615" checksum="6720A94E3708F643" modified="2021-04-07" version="1">VYVPLPAALHARWVAAALRAGKHVLAEKPLTTDAAATADLVALAGRRGLVLRENVMFVHHSQHRAVGRLVADGAIGEVRTFRAAFAIPRLPDDDIRFDPALGGGALADTGVYPVRAALLLLGHHLQVAGAVLLRDGAGTGVDIGGTALLRTPAGVGAHLTFGLDHAYRSRYEIWGSDGLLTLDRAFTSPADHHPRVRLEREGAVQEIVLPPDDQVLATLADFTEAVRAGAPSDPAIQRQADLLDAVRAHASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDF7</accession>
    <name>A0A7K2ZDF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000651">
        <property type="protein sequence ID" value="MYW30305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="7497" checksum="1E0C8B0CE6940A9F" modified="2021-04-07" version="1">PLARCLHRAGSTGAPAAGPVARLAEAMRAEQAGAAVARAQRAGVLITAPVGLCFLPAFLAVGVAPVIIGLAGGLLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDK7</accession>
    <name>A0A7K2ZDK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000656">
        <property type="protein sequence ID" value="MYW30355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="33093" checksum="8189F21C0BCB04E6" modified="2021-04-07" version="1">MTDLVIRALTPSDADLFSSLHETALVGRGAFGQRYATVADGGEYRPDWTWVALRDGKVVARAAWWGGPEDTEPVVLNWFDFAGGEAEAGAELLRRAPFDKEYELIAPAGWRDDPAVRAAVEVRLAAATAAGMKPLVERYRYRWTPGCPLPERTGRLTYRPEPDDAVVLDVLRRVHSATLDAHARKAIEGPGGLEAAAQEELDFFHWCPSPREWWRLAYTPDGEVAGIQVPAHNPSGPCVGFIGVVPEARGHGYGYDLLVECTRFLVEQGAEFVAGATDQGNAPMAAAFARAGYPVIQEWVHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDL3</accession>
    <name>A0A7K2ZDL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="15010" checksum="4943CB53058A04AE" modified="2021-04-07" version="1">MLEHVPEPANSPSYAYWCERSTYASEDRDEPDCFARYSAATPELAIQRIRDEARVLLAVLPEGQRPALGWAEGVGRVRALGALYGGRTCGFSLRHGDGWSEWVVRPHLVLPAEPEALAAELSAEDAPCGVCALCAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDP4</accession>
    <name>A0A7K2ZDP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000679">
        <property type="protein sequence ID" value="MYW30471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="256"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="353" mass="37220" checksum="B999DE36133BAED2" modified="2021-04-07" version="1">AAARAIAPRLGAYAAEADRLRTLPAEAVRLLDDARLFDVLTPRVWGGGGLGFATALLTTEELSRGCASVGWVRAVMGGNTWTVAQFPVEARQEVFSAPSTRVALQLRLSGPPARRVPGGYLLRGMWGRFCSGIDHAEWIVAGVSAPAAPGADPEPHVMLLPQERTVGIDDWHTSGLRGTGSRSFTVPELLVPDHRVLPLSALDPGSPAPHGRPRTTPYRMAFAAVGTVALAGVLLGAARAALDTYAGSPSGAWGLDVSALTATVDTARAMLLADLDTLAASSTPGGTAEERARMRRDIAYAGTRCREVVNAVYEASGSAVIYDDSPVQRIWRDANAAAQHPTFDLRRWGATPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDZ1</accession>
    <name>A0A7K2ZDZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000690">
        <property type="protein sequence ID" value="MYW30495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="357" mass="37253" checksum="4FC2CE09F3C228E4" modified="2021-04-07" version="1">MSSALTDLCRYPIVQAPMAGGASGPQLAAAVADAGGLGFLAAGYKTADGVYNEIKQLRRLTGGPFGVNLFMPQPALADPSAVEVYRHQLAGEAAWYETPLGDPDSSGDDGYEAKVAILLEDPVPAVSFTFGCPTRDTLDAFAKAGTYTIVTVTSAEEAQAAQWAGADAVCAQGVEAGGHQSTHRDDPQADHTGTGLLSLVTQVRETVQIPIVATGGLMRGSQIAAVLAAGADAAQLGTAFLICPESGAHLLHKQALTNPLFVRTELTRAFSGRPARGLVNRFVREHGPYAPAAYPQVHYLTTGLRQAAAKAGDAQGMALWAGQGHRMARELPVGELIELLIDELEAARAALSMRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE23</accession>
    <name>A0A7K2ZE23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045975">
        <property type="entry name" value="DUF5931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19354">
        <property type="entry name" value="DUF5931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="306"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="415" mass="44246" checksum="6FD21582166D9F90" modified="2021-04-07" version="1">MAKRERVVRMSVEQPLWRALTGYRVLTMVYAVLLAIFGKDNFGQQRFERPWVAFAYLAFLFVWTLATLPKVRSAASCTKRFLGADLVVALTGIMLTPVADIHSQTFDGPTLPSIWTAGAVLAFAIKGGWRWAAFASTFVAAANIIQRGEPSRDTFHNVLLVWVASIAIGYVVEVARASERTLARALEIEAATRERERLARDIHDSVLQVLAMVQRRGTAIGGEAAELGRMAGEQEVALRTLVSSGLVPPTRVSEDAAEGAVVRTVDVDEESPDSAATRDLRTLLAPHAGARTSLAEPGAPVVLPAEAARELAAAVGAALDNVRVHAGDGAQAWILVEDEPGEVIVTVRDDGPGIPEGRLAQAEGEGRMGVALSIRGRLRDLGGTAEVISVPGQGTEVELKVPKAQVSRGKAGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE42</accession>
    <name>A0A7K2ZE42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="450" mass="49420" checksum="22B234544BF86E3C" modified="2021-04-07" version="1">MTVNANTSVAGGNTWRDLPAAQQPEYPDSEALRDVLADLASYPPLVFAGECDQLRARLGAVAKGEAFLLQGGDCAEAFDAVSAEHIRAKLKTLLQMSAVLTYAASVPVVKVGRIAGQYSKPRSKSTETRDGVTLPTYRGDSVNGFAFTEEARIPDPQRLKQMYHASSSTLNLVRAFTTGGYADLRQVHAWNQDFVKSSPAGQRYEALAREIDNALNFMKACGTDPAEFKAVEFYASHEALLLDYETALTRTDSRTGELYDTSGHMVWIGERTRQMDGAHIEFASKVRNPIGIKLGPTTTVDEALGYVDRLDPEREPGRLTFIVRMGADKVRDKLPELVEKVTASGATVAWVTDPMHGNTFEAASGHKTRRFDDVLDEVKGFFEVHKGLGTHPGGIHVELTGDDVTECVGGGHEIFVDDLHQRYETACDPRLNRSQSLDLAFLVAEMYRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE49</accession>
    <name>A0A7K2ZE49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenazine-specific anthranilate synthase component I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="122"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="441"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="632" mass="68386" checksum="7B594603E391A56F" modified="2021-04-07" version="1">MSRTAPRTAFDLVRRLLADDAPPFALLRRRTPGRDHDHVEVLIGRVREAEQLADLPVGASPALALVPFRQIAERGFDVRDDGTPLSVLVADESHELELAEVLAALPAHDVVVEDRGFDVPDAEYAEIVRRVIRDEIGQGEGANFVIRRTFRGEIPGFRRADALALFRRLLSGERGAYWTFVVHTGERVLVGASPEVHVRMSGGTVVMNPISGTYRYPAEGPTAESLLAFLGDRKESEELSMVVDEELKMMCTVGDMGGVVVGPRLKEMAHLAHTEYELRGRSSLDVREVLRETMFAATVTGSPVQNACRVIERYEQGGRGYYAGALALVGQDASGAQTLDSPILIRTADIAQDGSLKVPVGATLVRHSDPESEVAETHAKAAGVLAALGVRPGRPEAEAGRPLLAADPRVQAALDDRRGSLAPFWLRMQERTRELTGHALVVDGEDTFTAMLAHLLRSSGLEVSVRRFDEPGLREMVRAHRGPVVLGPGPGNPGDLADPKMRLLRELAAGLVREHRYGLLGVCLGHELIAAELGMEIVRKAVPYQGAQTRIELFGRPETVGFYNSFTARCDGPAAAELAAHGIEVSRDEESGELHALRGPGFASVQFHPESVLTVRGSAIVTELLAGLPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEX1</accession>
    <name>A0A7K2ZEX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000786">
        <property type="protein sequence ID" value="MYW30901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="13437" checksum="5CA4C3380A694EB5" modified="2021-04-07" version="1" fragment="single">MSSSDQQYPYPYDPQPQPQQHQHPQAPQDWPDGTAGQSALPQEPGGHDQGGTQTWQAPTWDTQYQPTIRRDPQPYQGQVQGYGQQQPAAYGSGQPDSYGTPQPQYQEPQHQQPYQEPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFA4</accession>
    <name>A0A7K2ZFA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_17360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000813">
        <property type="protein sequence ID" value="MYW30998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028157">
        <property type="entry name" value="PELOTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011215">
        <property type="entry name" value="PRTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041688">
        <property type="entry name" value="PRTase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022537">
        <property type="entry name" value="TRSP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15608">
        <property type="entry name" value="PELOTA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11202">
        <property type="entry name" value="PRTase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15609">
        <property type="entry name" value="PRTase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12500">
        <property type="entry name" value="TRSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRTase_2" evidence="3">
        <location>
            <begin position="37"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="TRSP" evidence="1">
        <location>
            <begin position="276"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="PELOTA_1" evidence="2">
        <location>
            <begin position="735"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="832" mass="88475" checksum="C8A5E691AEC22151" modified="2021-04-07" version="1">MSGRARREEAVDVVWSGDWVAERLGVALEGDGELHELLGLALRRNPKRAHLLVSNVLGKHVPQRPSVVYGAGYGLGERVRALLGAEESRRAVVLGYAETATGLGHAVADGLRDAPYLHSTRRPVAGVAQAGGFEEAHSHATSHLLLPEDPELLAGGAEASTLVLVDDEFSTGNTVLNTIRALHETHPRERYVIVALVDMRSAGDRDRLTVFAAGIGARVDLVTRSSGTVTLPEGVLERGQALVADQEAEQAGRADEAVARAPVTRVALDWPAEVPDGGRHGFTPAHRAALEAALPGMAERVADALDSDVRRVLVLGFEELMYAPLRLGTALEAAMGSDAEIRYSTTTRSPVLAVDDPGYAIRTRLVFPAHDDPADGPGDRYAYNVAGADFDAVVAVVDSLADTPELHAPDGLLARLAAHTGQVLLAVVPSYAPTPLQEPAVLPEPLRGPDFSSYAPEDVGWLLQDLSDTELEAPTEEREEAIQSGGAHYAESLPVEYQPSAEYQALFTAALDASAARIARAVGTVTETVLAERGPRPVLVSLARAGTPVGVLMRHWARHRHGLDLPHYAISIVRGRGIDATALRWLAAHHDPADVVFVDGWTGKGAITRELAAAIEEFEASGGPGGSAGPAGFNPEIAVLADPGGCVRTYGTREDFLIPSACLNSTVSGLISRTVLRADLVGPDDFHGGKFYRELADSDVSGDFLAAVSDRFDEVADQVEAETKELLAADRAPTWEGWAAVERISEEYGIHDVNLVKPGVGETTRVLLRRVPWKILAKRGAGTDLTHIRLLAEQRGVPVEEVDDLPYSCVGLIHPRFTRGATGADGKAVQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFC4</accession>
    <name>A0A7K2ZFC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000813">
        <property type="protein sequence ID" value="MYW30999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024197">
        <property type="entry name" value="UCP030802"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030802">
        <property type="entry name" value="UCP030802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="273" mass="29615" checksum="7A22AB37C5BDCC5D" modified="2021-04-07" version="1">MSTASSTTLVASDLDRTLIYSAAALDLAMPDAEAPRLLCVEVYGHKPLSYMTETAAALLTEVAGSTVFVPTTTRTREQYHRIHLPGPAPQYAICANGGHILVDGVSDRDWQAQVEARIADECAPLTEIRAHLATTADPAWLLKERVAENLFAYLVVERPLLPEEWVKELAVWAQERGWTVSLQGRKIYVVPVPLTKSAAMNEVARRSGATRTLAAGDSLLDADLLLAADLGWRPGHGELAENDWRAPHVMALEERGGAAGEEILRRFLAASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFM5</accession>
    <name>A0A7K2ZFM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpD</name>
        <name evidence="13" type="ORF">GT040_18330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="WWKE01000861">
        <property type="protein sequence ID" value="MYW31177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="161"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW31177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="483" mass="52282" checksum="C95B8D3C9B21C20E" modified="2021-04-07" version="1">MTTTIDSAATAAATGRVARVIGPVVDVEFPVDAMPEIYNALHVEVDDPAEAGARKTLTLEVAQHLGDGVVRAISMQPTDGLVRQAPVTDTGTGITVPVGDITKGKVFNTLGQILNEPEAEAQITERWPIHRKAPAFDQLESKTEMFETGLKVVDLLTPYVKGGKIGLFGGAGVGKTVLIQEMIMRVAKLHDGVSVFAGVGERTREGNDLIDEMTESGVLEKTALVFGQMDEPPGTRLRVALSALTMAEYFRDVQKQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGVLQERITSTRGHSITSMQAIYVPADDLTDPAPATTFAHLDATTVLSRPISEKGIYPAVDPLDSTSRILDPRYITQEHYAAASRVKGILQKYKDLQDIIAILGIDELGEEDKLVVHRARRVERFLSQNTHAAKQFTGLDGSDVPLDESIAAFNAICDGDYDHFPEQAFFMCGGLDDLKAKAKELGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFU8</accession>
    <name>A0A7K2ZFU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000863">
        <property type="protein sequence ID" value="MYW31200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="22859" checksum="3BF96F322FE5A996" modified="2021-04-07" version="1">MSLRKLRKECEAQLADLPIPAPFSLAGLVANMEAARGRTIRLHEMPDRLARVNAACGLRLKAGDTSLVLYRRRPTAYQTEHVILHELCHEWFDHGTTLDAEQLRTLLPVFDTSLIARMISPEAAASFTSGGSTVQARAQYATHDERMAEFGASLIPRMARDLTTDDMVGRLTDSLSRPVAHRRRGPFPLISRIRRIPKTPRKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFV5</accession>
    <name>A0A7K2ZFV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein GT040_18500</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000865">
        <property type="protein sequence ID" value="MYW31210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030570698.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000865.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="7847" checksum="8F26FF0C5673E2FE" modified="2021-04-07" version="1">MNPDDPLLAILVCPLDKGPLALLTDEEALYNPRLRLSYPILDGIPQLLPSSGRKVDADAHERYLAHLKASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG99</accession>
    <name>A0A7K2ZG99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_19385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000908">
        <property type="protein sequence ID" value="MYW31377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg" evidence="5">
        <location>
            <begin position="109"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="6">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="395" mass="43316" checksum="9CA6FA5CEBC079CA" modified="2021-04-07" version="1">MIIRREGARMARSAQESATGSVRRPTVAPPGPGPLPVGGPEPVLDEQDHLLITALQTSPRAEWQRIGKALGVDASTAARRWQRLTEAGHAWLSCYTVAVGPAVPIVAFIEVDCAAGALHEVALEIADDPHLITIDHVTGSRDLILTAAFPDQPALARYVGFRLDTLPGVAATRSQIATALHAEGSRWRLDRLDPDGREALTRDRPHPAPRRGLPSPDELDTRLSMLLAEDCRQPAARLAERTGVSASTVRRRLERMHREDALVYRCEVARYLSGWPVSVTMWGVAPPGDVARITSQLIGLREMRLCASLSGPYNLLLTVWLRSAEDIASFEARIGSRFPELAIADRAVTLWPLKLAGQILDPQGRHLRGVPVRFWEDPVAERAEGDLLERLRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGM3</accession>
    <name>A0A7K2ZGM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA alkylation response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000936">
        <property type="protein sequence ID" value="MYW31513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="16040" checksum="13A613B7CEB52F49" modified="2021-04-07" version="1" fragment="single">MAATTHTVTNQVPPLVGYDVFAADRALSEAVERHIEPGVLPVAREELSTLGQSAGSAQAQEWGAQANEHPPVLRTHDRYGHRIDEVEFHPSWHRLLGHAVSAGLTDAWGRPAGHVRRAAGFLVWTQAEAGHGCPLSMTHAAVPALRTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGS9</accession>
    <name>A0A7K2ZGS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Roadblock/LC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000956">
        <property type="protein sequence ID" value="MYW31546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="44" mass="4612" checksum="030A53F240E785E4" modified="2021-04-07" version="1">SLAVLAHPDADIGLVGYEMALLVDRAGTVLTPDLRAELQGSLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHA6</accession>
    <name>A0A7K2ZHA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_21155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001002">
        <property type="protein sequence ID" value="MYW31717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="362" mass="38369" checksum="B228627A8F7C68F1" modified="2021-04-07" version="1" fragment="single">MIEAVGLTKRYGAKTAVDDLSFQVRPGAVTGFLGPNGSGKSTTMRMILGLDRPTAGHVTIGGHPYRSLPNAPRQVGALLDAKAVHGGRTARAHLLSLAQLAGIPARRVDEVLGVVGLRDVAKRRSSGFSLGMGQRLGIAAALLGDPQVLLFDEPVNGLDPEGIHWVRNLMKTLAAEGRTVFVSSHLMSEMALTADHLIVIGRGRLLSDMSVTDFISANSADFARVRVPENAPQEREKLTSSLIEAGGSVMSEPDGALRVTGLPLPRISDLAHGADVRLWELSPHRASLEEAYMRMTQGVVDYRSTDDAKAGLLEPPQAPYGSYGDAQGGYGAAPGYGQPQSAEAPQQSWYAPPPPGRNPYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHC9</accession>
    <name>A0A7K2ZHC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/LC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001014">
        <property type="protein sequence ID" value="MYW31750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030571107.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001014.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14253" checksum="95F21844B7547AA7" modified="2021-04-07" version="1">MNPDLSWVLNDVLQVPGARHAILVSADGLLLANSSEIGRDDAETVAAAMSSMQSLSRAVAPFIGTRSPGRWRQTLLEYEDGWIFLIAAGTGAYLAATAAADVDMEAMSFRMQQQVTALGKAMTTPPRQNAGSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHG9</accession>
    <name>A0A7K2ZHG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit</fullName>
            <ecNumber evidence="16">4.1.1.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GT040_21600</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.71" evidence="16"/>
    <dbReference type="EMBL" id="WWKE01001018">
        <property type="protein sequence ID" value="MYW31802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="15">
        <location>
            <begin position="797"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW31802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1145" mass="126720" checksum="34EEB7EF0A8C1EEB" modified="2021-04-07" version="1">AAKPAAAPAKAKPKADDSTEAPAGPEYVTLRGPSAAVAKNMNASLELPTATSVRAVPVKLLFDNRIVINNHLKRARGGKISFTHLIGYAMVQALKAMPSMNHSFAVKDGKPTLVKPEHVNLGLAIDLVKPNGDRQLVVAAIKKAETLNFFEFWQAYEDIVRRARIGKLGMDDFSGVTASLTNPGGIGTVHSVPRLMPGQGLIMGVGAMDYPAEFQGTSQDTLNKLGISKVMTLTSTYDHRVIQGAASGEFLRVLSQLLLGQNDFYDEIFKALRIPYEPVRWLTDIDASHDNDVTKAARVFELIHSYRVRGHVMADTDPLEYRQRKHPDLDITEHGLTLWDLERDFAVGGFAGKSMMKLRDILGVLRESYCRTTGIEFMHIQDPKQRKWLQDRVERPRTQQPEREEQLRILRRLNAAEAFETFLQTKYVGQKRFSLEGGESVIPLLDAVIDSAAEARLDEVVIGMAHRGRLNVLANIVGKSYAQIFREFEGNLDPRSMHGSGDVKYHLGAEGTFTGLDGEQIKVSLAANPSHLEAVDPVLEGIARAKQDIINKGGTDFTVLPIALHGDAAFAGQGVVAETLNMSQLRGYRTGGTVHVVINNQVGFTAAPESSRSSMYATDVARMIEAPIIHVNGDDPEAVVRVARLAFEFRQAFNKDVVIDLICYRRRGHNEGDNPEFTNPQMYTLIDKKRSVRKLYTESLIGRGDITLEEAEQALQDFQGQLEKVFAEVREATSQPAAPHIPEPQAAFPVAVETAVSAEVVKRIAESQVNIPESITVHPRLMPQMQRRAASVENGTIDWGMGETLAIGSLLMEGTPVRLAGQDTRRGTFGQRHAVLVDQVTGEDYTPLLYLTEEQARYNVYDSLLSEYAAMGFEYGYSLARPESLVIWEAQFGDFVNGAQTVVDEFISSAEQKWGQTSGVTLLLPHGYEGQGPDHSSARPERFLQMCAQDNMTVAMPTLPSNYFHLLRWQVHNPHHKPLIVFTPKSMLRLKAAASKIEEFTVGGFRPVIGDDSVKAENVRKVVFVSGKLYYDLDAEREKRGDTETAIIRLERLYPLPGAEIQAEIAKYPNAEKYLWAQEEPANQGAWPFIALNLIDHLDLAVGADVPHGERLRRISRPHGSSPAVGSAKRHQAEQTQLVNEVFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHI2</accession>
    <name>A0A7K2ZHI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_21575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001017">
        <property type="protein sequence ID" value="MYW31797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029573793" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="7">
        <location>
            <begin position="38"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="5">
        <location>
            <begin position="296"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="6">
        <location>
            <begin position="974"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="762"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1424" mass="153046" checksum="571B68E4D86B3251" modified="2021-04-07" version="1">VAALTSGALVAGLTPATAAATATDVTPRASAISAYDAVDPFIGTQLDPAQNKGNSAYGNTWPGATTPFGMVQSSPTTYRSSDGDQKGGYEYSADKIRGFGMTRLSGTGCEGRFSAFDFPVLPYTGPLDGGALPTSPGTKIDPYYLDFDHRDETAAPGHYTVGLGNGVETELTATTRTAVNRYEFPARKDSSTLILDVAGSNNRVFDSEVTVEGRTVSGWVETASVCDEGGRYRAYFSSTFDRAFTSYGTWQGGQVTPGAATARGGAAKHGSGAYLVFPKGATVTARTGLSYVSVANAARNAEEETGGRSFDQVRKATARVWKDALSTVKATGGTKSERVKFFTALYHSLLHPNIADDVNGQYPGHDGKVRKVSAGRHHYVTYAGWDMYRGQAQLIALLFPKVGDDINQSLVDLVKQTGAWPNWPHLNQSQQKMSGDSLQVVLSSIDAFGSVDYDRKAALASMRKTQSLPADTTKRAHAQQYLSAGFIDNGKGDSATSKTLEYAIDDFAIAQLASRLGEKATYDQFMTRAQNWQNLLDPETDRIRPRGRNGFDRSFNLGERGNQFEQATGYQYGWMVPQNMGTLIEKRGGVEPVTRDLDEHTKALDAGVYNTTGAYLSNQPSFSMPYVYNWLRQPHRTSEVLRRATDEMYGTTPSGLPGNDDLGSLSAWYVWANLGMNPTVYGTANLVLSSPMFDRITIDSADSDRRITIRADGAASDKPYVTGLKVNGRATSKSWLDEDFARAGGVLTYTMGAAPGTWGTGAADVPPSYTEGSDARNNIGSTPDGQGRLGSLDLSDNSLSREKLAAAGATPGAKLPLGDTGVTFTWPKAKQGQPDNWIPHGQRVDLAGGSGKGVKATGISFLGLATNGPSQGLAFVEYEDGSTQNVAVQFTDWTPGTNYLYGNVPLVATEGRNKVNGTSDTTRTVVFGTAPQVLDGKKRVTSVTLPQGTDRGIMHIFDVALTTDPDLEAPGVTPERIVLTPTATPATSQAVTWRTGSGTTQGEAQFRPEGSNSAWRKAKATTNEELLSGGVPTRTHSAVMEGLKPGTAYEYRVGTGTKLSGTYVFTSAGRPGEAFTFLYFGDAQNDLKAKWTPVVDQAYKRFPQAIGSVNAGDLVDSGGNAGQWDEWFGAMNGRSRTTNVIAAPGNHEYNADLFLRTWKSTFAYPANGPTPAPAKDDTPAERQRAAYETHMAKSIGETAYYTDYQGVRFITLNASTHDARELMTPPDLPPCSTGCPDPQQLWLDLQARWLDQILADNPNKWSVATFHQPVFSAAVGRDEKPIRDAWLPVFQRNDIDLVLMGHDHVYARGYVNADATDTPGVTTGPVYAVAMAGPKYYELSPAGENVWTRNGATQVAREAHTSTFQGITVTKDTIRYEAVVAAKWDDRSTTDKEVGETLDAFTITKSDDGVKYVTEDGVAAPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHN6</accession>
    <name>A0A7K2ZHN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2809 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001031">
        <property type="protein sequence ID" value="MYW31862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021257">
        <property type="entry name" value="DUF2809"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10990">
        <property type="entry name" value="DUF2809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029853038" evidence="2">
        <location>
            <begin position="29"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="13402" checksum="CB217BBA924B8705" modified="2021-04-07" version="1">MRRSPSGTRVVAAGAAVVTVAAGLGVRAAGDGAFAKYAGSALYTVLLCALVALCAPRARPVAVAATALALSWAVELLQLTGVPAELSAHSTAARLVLGSTFNAPDLFWYAVGAAAAWAVRAGARRLAVRWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHR9</accession>
    <name>A0A7K2ZHR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001044">
        <property type="protein sequence ID" value="MYW31901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="2"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="20809" checksum="A1B05EFFFFDB897E" modified="2021-04-07" version="1">GWLIALRAERPDTAVSLLVGNSADVARRLVTGEADLGFVEGLSIPEGLDGTVIAHDRLVVVVAPSHPWARRRTPLLPGELAATPLILRERGSGTRQVLDAALAVHGGLAQPLLELSSTTAVKGAAESGAGPCVLSELALGEELSSRRLVRIPVAGVRLRRQLRAVWPAGHRPTGPARDLLSRTGRSTDDPGSVTASDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHY1</accession>
    <name>A0A7K2ZHY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="336" mass="36394" checksum="72B60C68A8169EAB" modified="2021-04-07" version="1">MRLGLALGYWGRGPDPGHLALAQEAERLGYDSVWTAEAWGSDAFTPLTWIAAHTSRIRLGTGIAQMAARTPTATAMHALTLDHLSGGRLLLGLGLSGPQVVEGWYGRPFPKSPLTATREYVEVIRQVLAREAPVEVAGSFHSHPYAGPDATGLGKPLKPITHPLRASLPVLLGAEGPKNIAQTVRIADGWLPLYWSPHRTDVYAASLAGLREGFMIAPMARAHVCDDVAEGLLPVKAMLGFYIGGMGHAARNFHADLMGRMGFEEEARRIQHLFLQGRKEEAIQAVPDTFADEISLVGPRARIAEKLVEWRKGPVTDLLVTAPDPHTLRVLAELNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI01</accession>
    <name>A0A7K2ZI01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">META domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_22490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001062">
        <property type="protein sequence ID" value="MYW31967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029502022" evidence="2">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="3">
        <location>
            <begin position="42"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="3">
        <location>
            <begin position="154"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="28576" checksum="4B844B35F61CB8D7" modified="2021-04-07" version="1">MRTQRMAVSVSVLALLTLAACGTEPGSGSGGDGGDTVQSDVPVTGVAWSVDSLTVDGKKTEAPEGSRLEFDPKGRAKAGFGCNHISADAQVKGDRITFGKPVSTQMACDEATEKAEKAALAAMDGEVTAKLSGEKLTLTTEGGDTFALSEEKPAALAGTRWAVTTLLSGETATSVPADLPKDRVPHLTFGEDGTVHGNSGCNSFHGKADVKGSAITFGTPAGTRKMCPEAEMETERAVLAALDGPATYTIKGSTLTVTSKDGKGIGATATPATTEGTQEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI27</accession>
    <name>A0A7K2ZI27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dhbC</name>
        <name evidence="6" type="ORF">GT040_22640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001064">
        <property type="protein sequence ID" value="MYW31994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="135"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="401" mass="41619" checksum="73D4F3A980935174" modified="2021-04-07" version="1">MSTASQVATHVPPADPAHPSVGAATSLLDAYTPGDTFLATPGRTLLARGPGREVPHDERPLTDRVDATLAEAVAAGQESPVVIGAVPFDHTAPAALNVPTSVRTAPPLASDPLIALPAGPSATADWQIRPVPAPEVYGEGVAAAVARMWRGEFSKVVLARTLELTSGAPLDLPAMLQRLARRDPSGYTFALPTGPARTLIGASPELLVSRHGDQVVANPLAGSTPRSDDLAEDVRRAATLLESVKDLHEHAVVVDAVHQALAPHCTGMTVPARPTLIRTATMWHLSTTVTGTLSSAGTSALDLAMALHPTPAVCGTPTQTARQVIAETEPFDRGFFTGVVGWGNADGDGEWVVTIRCAEAEERTLRLYAGAGIVAASEPEAETAETGAKFRTFLSAVGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI70</accession>
    <name>A0A7K2ZI70_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GT040_22745</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001066">
        <property type="protein sequence ID" value="MYW32015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="18">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="153"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MYW32015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="398" mass="43471" checksum="CFCA2BB7D7665631" modified="2021-04-07" version="1">MLSDRSTATVRATLPAVGAAIGDIADLFYKKLFQAHPELLRDLFNRGNQASGDQRTALAGSIAAFATALVEHPGTRPDVMLNRIAHKHASLGVTPEQYEVVHTHLFAAIADVLGDVVTPEVAAAWDEVYWLMANALIAIEARLYAQQGVVAGGVWREWEVAARVEETEDVATFRLRPADGGDAPVFRPGQYVSVQVELADDARQIRQYSLSSSPGSRLRSITVKRVRGQEYPDGEVSRHLHEHTRAGDRVRVSVPYGDLVLDHLDAPLLLASAGIGCTPVLSMLEHLAEQGHDRPVTVVHGDRSPADHALRAHHIRLTEKLPAAEPHFWYESPEAGHPAHRTGLVDLNGITVLPGTHAYLCGPLPFMRTVRTRLLEAGVRPADIHYEVFGPDLWLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIG5</accession>
    <name>A0A7K2ZIG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_23430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="51"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="363" mass="39320" checksum="90FAF67BD810D3D4" modified="2021-04-07" version="1">MVATALDLPAGSPGGSVELFLDLYTGNRPGIPAQAFMLATGQSDARPRAGLKLLRVRGKCLEGPAFGRYVTELREALRRAINPSEIDVLHLQHLAFGATPALIRALPAPPRIALVHGTDLLFAESHRDQNRVLRETARSAEAIVVPTGAMADRLLKLVPSTDRRKIAHISWGVPDHLLSSPPPRRAMPPASHLRLLYAGRLTAEKGGEALIKSLAPARGIELSIAAPQDEFQAMTPLLRRAGVQARYLGWLHRPQLWKTFADHDFLVMPSTTLEAMGLVAVEAQACGLPVLYQPVPGLNEVLGDSAAPVDFTRPGAVARGLQRMRDSREVLPALREAGLANARRYPLSSTQRALHALGHQVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIQ0</accession>
    <name>A0A7K2ZIQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <shortName evidence="2">MSH acetyltransferase</shortName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mycothiol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mshD</name>
        <name evidence="4" type="ORF">GT040_23820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol</text>
            <dbReference type="Rhea" id="RHEA:26172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16768"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="EC" id="2.3.1.189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. MshD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001112">
        <property type="protein sequence ID" value="MYW32214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035447">
        <property type="term" value="F:mycothiol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01698">
        <property type="entry name" value="MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017813">
        <property type="entry name" value="Mycothiol_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021524">
        <property type="entry name" value="MSH_acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03448">
        <property type="entry name" value="mycothiol_MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="136"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 1" evidence="2">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="222"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="30174" checksum="90C16DF6BA0E65F6" modified="2021-04-07" version="1">LELLGEAARFDGRQAVSEQGRLRIRGGHRDGVRHFLLTSGGTLAGYAQLEDTDPVEAPAAELVVHPEQRGTGHGRALGAALLAATGKRLRVWAHGGSSAARHLAQVLGLSLFRELRQLRRSLIPLDLAEPVLPEGVTVRTFEPGRDDAAWLAVNRAAFAHHPEQGSLTQQDLDDRKAEPWFDPKGFFLAERGGEIVGFHWTKVHAEERLGEVYVVGVLPDAQGGGLGKALTAIGLHHLAAEGLPTAMLYVDADNTAAVTVYERIGFATHEVDLMYRTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ12</accession>
    <name>A0A7K2ZJ12_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_24530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001151">
        <property type="protein sequence ID" value="MYW32346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="10">
        <location>
            <begin position="125"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="421"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="608"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW32346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="761" mass="81074" checksum="EE33F519F30A7B7D" modified="2021-04-07" version="1" fragment="single">MQGRFKRDGSAPAEQEPRGGTDRGSSPQHAQNPGPGAAGDNGDRAKPPGSAPSGGAEPSTPSASRGPVDTGSRIALRNWRISTRLVSLLALPVVAATSLGGLRINESMTDMQQLEHMQLLTQMTKQATSLAQALQVERDQSAGPLSNGSKATDYKVSQPREKTDRAKDAFLDATNEIGDFENDDALESIHASVAQIASQLGDIRSIRKSAYEDGAPSLNTIDQYSQLITSLLSLSQDMAQATSNPDMIKRTRALAAFSSAKEYASIQRAVIAAALPGGSVKEPHLNENDKQFGSNALDKETRAISSFKSIYGSTGESAVDLMAPLDNGNNPEINAANMYAKHILDTPNGIDGAKVRSYMDWYDQSSTKIDAMKTIETTLLSDMEAKARELREASQREAIINGAVILLVLGVSLVGAFVVARSMIRSLRRLQDTATRVAQDRLPELVKQLSETDPQDVDTSVESVGVHSRDEIGQVAAAFDDVHREAVRLAAEQALLRGNVNAMFTNLSRRSQGLIQRQLSLISELESREADPDQLSSLFKLDHLATRMRRNGENLLVLAGEEPGRRWTRPVPLVDVLRAAASEVEQYERIELSAVPATEVAGRVVNDLVHLLAELLENATSFSSPQTKVRVTGHALPDGRVLVEIHDTGIGLSPEDLAAINERLAQPPTVDVSVSRRMGLFVVGRLSLRHGIRIQLRPSDSGGTTALVMLPVDVAHGGKQPPSKQGSGQQPGGAPGGLLAGNGNGAGAGQRPGIGGGPGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJE3</accession>
    <name>A0A7K2ZJE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001181">
        <property type="protein sequence ID" value="MYW32466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15176" checksum="622B2B3FC4C14E04" modified="2021-04-07" version="1" fragment="single">MSDVAAVVDDLREESDELDALVGALEPGRWRGPTPAEGWTVAHQIAHLAWTDEVALLAATEPDRFGDEVAKALAAPEAFVDQAAGALVAAHAPDVLLARWRDGRQRLDKVLRDAPAGARIPWYGPPMSVASMATARLMETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJK8</accession>
    <name>A0A7K2ZJK8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">cysC</name>
        <name evidence="3" type="ORF">GT040_25510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="187" mass="19799" checksum="08B136C9535D60B9" modified="2021-04-07" version="1">MTEPNAGPVTRQGGTVWLTGLPSAGKTTIALSLAERLRADGHRVQVLDGDELRAALSADLGFSKEDRDTNVRRTGYVAGLLAGHGVTVLVPVIAPYAASRAAVREQHAERGVPYLEVHVATPVKVCAARDVKGLYAKQAAGLLHGLTGVDDLYEEPVAPDLRIHTQDETVEDSVRRLHALLTAGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJR6</accession>
    <name>A0A7K2ZJR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001200">
        <property type="protein sequence ID" value="MYW32585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030570241.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001200.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="65" mass="7045" checksum="D256EE1B26D7F6E6" modified="2021-04-07" version="1">MFWPMLAIALGFLGVAVLGVLAIKVFVEAQRLGRQVTTTTERINQASEDLERAATRLAATGDSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJZ9</accession>
    <name>A0A7K2ZJZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pup--protein ligase</fullName>
            <ecNumber evidence="2">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pafA</name>
        <name evidence="4" type="ORF">GT040_25735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001200">
        <property type="protein sequence ID" value="MYW32579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026242080.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001200.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="453" mass="52187" checksum="D70777156A5EA1FF" modified="2021-04-07" version="1">MDRRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDNVTELVTHDKAGERILEGLLVDAERRLHEEGIAGDVYLFKNNTDSAGNSYGCHENYLVARHGEFSRLADILIPFLVTRQLICGAGKVLQTPRGAVYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTMLLKVGATDLVLRMIEAGTVMRDLTLENPIRAIREVSHDLTGRRKVRLASGREASAIEVQREYYEKAVDFVERRGIRTGTVDQVLELWGRTLDAIEAEDLDRIDTEIDWVMKYKLIERYRAKHNMTMSNPRVAQIDLAYHDIHRRRGLFYLLERKGQTARICNDLKIFEGKSVPPQTTRARLRGDFIRRAQEQRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDERVEKLIAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK43</accession>
    <name>A0A7K2ZK43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001204">
        <property type="protein sequence ID" value="MYW32619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029792987" evidence="1">
        <location>
            <begin position="27"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="284" mass="31045" checksum="C19AA636350F0B7C" modified="2021-04-07" version="1">RVASLGAVVAVTAAALVITQVVGPSAPDRSTPATVVGDLDLTSPAAALNRAADHLERQEVPPEPRADQWVYIREVDGWQEQQWKELPEEVRKKTPMTYSPDRWIPYDDEAAGNDTSDTDHRTARESYRIAAALPEDPEALLARLREVFPTGSGPDGAPEAKDEHSFRALSVLLESYPIPPDALARIYRAMATVGGVGVTGHLIQDASGREVIAVTRKYDRSESRREILLDPVDYSYAGNRDVVTRTHKVPTPKGYPAMVQKRGEVLIDIARTHAAVVDAKGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKN3</accession>
    <name>A0A7K2ZKN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_26930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001254">
        <property type="protein sequence ID" value="MYW32809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="6"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="407" mass="40999" checksum="27B81BE9096769A3" modified="2021-04-07" version="1">MNRPAIAVTGLGMITPAGHTTDTTWDGVCRGESFARTVPELQGCAVDFACTVSGIDLDDAVGGRTAFRMGRYVKFAVLAAREAVTDAGLDPAHWDGARVAVVVGTSSGGSAGLTEQAVALERRGPEATSPSGILLTIPSMPAAEIAIQMKATGPSLAPCTACSSGVTALSVARDMLALGQCDIAIAGATESIVFPVAMTGFARSGAAALRDGDPARLCRPFAADRAGLVMGEGAAIMVLERAEDARARGAAPRALLAGTGATTDAHHPTSPHPSGAVAEAAVDAALADAGWRAEDVGHVNAHGTSTPLNDATEAALIGRAYPHRPPVTAPKGVLGHCMGAAGAIEAGLTVLTLQHGIVPPIANLEAPDPGFAIDCVTKAPREVPVRRAVSHSFGFGGQNAVIALQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKP0</accession>
    <name>A0A7K2ZKP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001290">
        <property type="protein sequence ID" value="MYW32916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7022" checksum="D5A86403D03B81B2" modified="2021-04-07" version="1">GRVRADVLCALDEPAGTSALAHRLGLAPSSVSAHLSVLRGAGLLTSRRYGHQVLYERTPLGIALAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKT4</accession>
    <name>A0A7K2ZKT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Curculin domain-containing protein (Mannose-binding) lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001297">
        <property type="protein sequence ID" value="MYW32950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="1">
        <location>
            <begin position="227"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="614" mass="66487" checksum="FC19B5E07C381308" modified="2021-04-07" version="1">MRELPMFERLYPDVQLTSPSERFVLRCDSEGVAVVTDTDRDQVVWRAGAAGQLLLGHGYEVVVEGGEDDDTVWRSGFAAPGAQYLVLTDVGELELLDRTHVRLGNIRTGLTDPVPLGDAAPAAAITRDAYLVREGKTRRTVAREQDGWLRVCEYGKSGGMSYALTRPLVDWFEQEDTVLTWRRHLAGGSKSKSLLLCLVDSAGTVLWHEGTQRPHGPVPPGEPYAYGGPALEAGGRLRNQSLTSPAGTHTLAHQGNGDLTLYCHTERRAVWSTGTGWVDGGWAELSEDGVLSVRNTHGVPVWSSGPSGSGARRLVVGDDGRAELHDEAGRPVWSTGTHTACHGPTVDAPRGAVLRRGQTLGRHSLTSPDGRTVLGHWDERRLVLFGADQTWLWYAHLGETAEPGLRLDEDGMLRVLGEDRPPLGGPADELRVEEGGVVLCRADGTVVWRDGEAVAEPAADPNTPAQGGLVKSLPDTDETLLIRTDFSDPPAWQALLTTVTTPNQDGFVANVHPVDDLAYRDLTTEQILSAADELDTELLIVADKAALTAPEMPLLALLLVDESDECEEGEAGQEHGQLRVLASELWSVENNISLANMDWEDFENAADNGVFRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKT7</accession>
    <name>A0A7K2ZKT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">GT040_27740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001298">
        <property type="protein sequence ID" value="MYW32962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509618.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001298.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="6">
        <location>
            <begin position="33"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="148"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="257" mass="27482" checksum="1DAE9A67B87E4330" modified="2021-04-07" version="1">MDKGADATQADDKRDDTFSGRFMLKLSGEAFAGGGGLGVDPDVVHTIAREIAAVVRDGAEIAVVIGGGNFFRGAELQQRGMDRARSDYMGMLGTVMNCLALQDFLEKEGIDSRVQTAITMGQVAEPYIPLRAVRHLEKGRVVIFGAGMGMPYFSTDTTAAQRALEIDAEALLMGKNGVDGVYDSDPKTNPDAVKFDALEYGEVITRDLKVADATAITLCRDNKLPILVFELTAEGNIARAVKGEKIGTLVSDESTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKV2</accession>
    <name>A0A7K2ZKV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001300">
        <property type="protein sequence ID" value="MYW32984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="133"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="339" mass="36163" checksum="164903FFDEDC4A9C" modified="2021-04-07" version="1">MTAALKAGLIGLGSMGRNHARILAGLEGVELAGVVEPAGDRNGWAQGAPVLSTVDELLARGVDYAVVACPTGLHEKVGLQLADAGVCALIEKPLADTVEGARRLVEAFESRDLVAAVGHIERCNPALLSLRARLEAGELGDVYQVVTRRQGPFPHRIADVGVVKDLATHDIDLTSWVTGQAYTSIAAHTVSKSGRPHEDMVSAVGQLSDGTMANHLVNWLSPLKERFTSVTGERGCFIADTLTADLTFHSNAAVATEWEALRAFRGVSEGDMIRYAIPKREPLLVEHELFRDAVRGEPVDVCTLRQGLLTVEVAEAVLESASTRTTVTLTAPDRTEHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL25</accession>
    <name>A0A7K2ZL25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_28140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001307">
        <property type="protein sequence ID" value="MYW33040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22107" checksum="33C9195BB089D7A3" modified="2021-04-07" version="1" fragment="single">MAQSVGIKDVARVAGVSVGTVSNVINRPDTVGPDTRARVLSAIDRLGYVRSESARQLRAGRSRIMGLLVLDMGNPFFVDVARGAERAAREAGLGVMVCNSAQSPGEEAEYLSLFAEQRVRGVLLTPADATGRNIDAFRRHGIPFVLVDRVAEGTTECSVSVDDVAGGALAVRHLVEAGHRSIAYVSGPPGFNQVRDRRTGALAALAEAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL48</accession>
    <name>A0A7K2ZL48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14442" checksum="E0C6808E92AA50FE" modified="2021-04-07" version="1">MPGGVPEARHRVQEAMHAWGEPAERIEAAALIVTELVTNAVQHTSTRRIRCRLLRSAEGVRICVWNRGRARIPAPASPADAAGLPVEAAPPADGPDGDDSLDCLTEDGRGLLLVDALAARWGTRAALAGRLVWADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLC1</accession>
    <name>A0A7K2ZLC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S58 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001325">
        <property type="protein sequence ID" value="MYW33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="13620" checksum="C747100CFC33D00B" modified="2021-04-07" version="1">RRLAREREVAEAAGGGAPPFNTTIAVVATDAALVRAQAQKLAGTAHDGMARAVRPVHLLTDGDTVFALATGRVRVESENPFAVNEILAAGADVLARAIVKAVRAARSIQGPGSTFLAHADLYGEGPDGRPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLQ9</accession>
    <name>A0A7K2ZLQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AIM24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001358">
        <property type="protein sequence ID" value="MYW33248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="27457" checksum="599B51967431F663" modified="2021-04-07" version="1">MQSPLFNYTEQQSQDRYTIQNPQLLRVALTGQDDILARKGAMVAYQGLMDFDGEYQSQGQRRARAHTGEGLDLMRVSGQGTVYFANLAQYIHVVDVDREGMTVDSSYVLALDSSLHTEVIAVDSQYGISGSGKYQLNITGTGKVALMTSGQPLMMQVTPDKYVNVDADAIVAWSSALRVQMQAQTHSSGVFRRRGNTGEGWELSFLGQGFALVQPSEVMPPQNAQIGQGARAQFGMGQQGSYGQNQNNAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLW5</accession>
    <name>A0A7K2ZLW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001377">
        <property type="protein sequence ID" value="MYW33332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="311" mass="32968" checksum="230F79228FBF9F8A" modified="2021-04-07" version="1">MARRGAPAGGKDRSKDKGKGKKDRSTGRGTGRAEREPFAGPVDSGLAELIPDRERPDGWTLLLDGAPQSHVDLGDPAHLSFAYQRRLGHIIDLAAPPLQPLNVLHLGGGAFTLARYVAATRPRSTQQVVEIDVALVQLVRDRLPLDPQARVRVRALDAREGLGKFPDGWADLVIADVFSGARTPAHLTSAEFLTDVRRVLKPSGQYAANLADGPPLAHLRGQVATAAAVFPELALAADPVVWRGRRFGNAVLLASALPPAVAEFTRRVASDPHPGRVEHGRALMDFTGGAAVVTDAAAKPSPAPPPSVFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLX6</accession>
    <name>A0A7K2ZLX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_29750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001379">
        <property type="protein sequence ID" value="MYW33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="69"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="24043" checksum="EAFBB71EA3715671" modified="2021-04-07" version="1" fragment="single">EEDAAPQGALVTVADASAQRADHRRLTWVVSGGCALLVLLSAGVGHLLSGRAVRPALEALDRQESFLADAAHDLRTPAASLRTLAETALRGETDSTDVHRRTLRLAEGMGTLVDGLLTRARLMSGTAVLAVEPLRLDQLVEAVVEDVAGEGQRVAVRAEQAVVVVADPDLVRRAVANLVGNALVHGHQPGEPAEVEVTVGGDEATTAVTVEDAGPGLPPEVAGALFDRFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM59</accession>
    <name>A0A7K2ZM59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPDPase_memb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001392">
        <property type="protein sequence ID" value="MYW33422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018476">
        <property type="entry name" value="GlyceroP-diester-Pdiesterase_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10110">
        <property type="entry name" value="GPDPase_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GPDPase_memb" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16498" checksum="C44D89F98AE4F391" modified="2021-04-07" version="1">FTAACVVILWLQVSLALAAPALMLERQGVRAALRRSAKLVRGAWWRTFGILALTYLLVFLVSFLVSIPFGVVAVIADGTDISEFFESGGPSLGWPFLIITGIGEVVVSTLLYPFVAGVMALLYVDQRIRREALDLDLARAAGLPGHAPDTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM68</accession>
    <name>A0A7K2ZM68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001389">
        <property type="protein sequence ID" value="MYW33400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="31266" checksum="49CB89236E860970" modified="2021-04-07" version="1">MRTIVVLDAPSNLGLRPPAPGTVPGCYKLAGALREQRIVQRIGALEGGVVVPPRYDRGDWQAGDGVFNAAAIARYTRTLADRIEGHVRAGEFVLVLGGDCSIQLGAALALRRLGRYGLAAVDGSADFRHLGNSDHVGAAGGEELAIATGRGQADLSDLEGLRPYLKDEDVRLFGMRDEDADQAELTALKIPHTTVGQIREWGAAELARATVESLETPALDGYWVHLDADVLDPSVMPAVDSPDDGGLLPEELAPLLGTLLSSPRCVGLNVTIYDPDLDPDGTAGALLTDLVVGALAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMB4</accession>
    <name>A0A7K2ZMB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucanase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_30570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001407">
        <property type="protein sequence ID" value="MYW33495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="36551" checksum="1F9A0BA499D38FFD" modified="2021-04-07" version="1">MYGSYTGYTGLRSAGTATAVCAALLLAGCSGDSGGDGDGGTDGGPAVVGQQPEAKGPYWVNPDGTAARQVATYEKDGDQEKADLIRKIAEQPVGEWIGPDDPEGEARRVTGAATKADRHALLVLYNIPYRDCGQFSKGGAADGNAYRAWVDGVAQGIGERRATVILEPDALLHLVDGCTPQEHHDERYALLESAVERLKRQPATQVYVDAGNAGWQSPEALREPLRRAGIERADGFSLNVSNFRTTAVSTEFGRKLSVKVGNKPFVIDTSRNGNGPYEGGDPAETWCNPPGRALGEPPTTTTGDDTVDAYLWIKRPGESDGDCKGGPKAGAWWPEYALGLARATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN35</accession>
    <name>A0A7K2ZN35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diiron oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001456">
        <property type="protein sequence ID" value="MYW33765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="317" mass="36432" checksum="9B09BA5383B6BA33" modified="2021-04-07" version="1">MTTVPTETPATALDVTVLRDALGPLRDREQIAARLLESSAKHSFDPDTELDWDTAVEEGKWFWPPELLSLYDTPMWHRMSEEQRLDLSRHEGAALASLGIWFEIILMQLLVRHVYDKPVTSNHVRYALTEIADECRHSMMFGRMIDWGGAPTYEVPRVYHNLARVLKTVSTTPGSFAATLLGEEILDWMQRLTFPDDRVQTLVRGVTRIHVIEEARHVRYAREELRRQMVTAPRWERELTKVSCGEAARVFSVCFVNPQVYENVGLDRREAVTQVKASGHRREVMQTGSRRLTDFFDDIGLLNGVSRRLWRSSGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZND2</accession>
    <name>A0A7K2ZND2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glutamine synthetase</fullName>
            <ecNumber evidence="9">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glnA</name>
        <name evidence="11" type="ORF">GT040_32385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="10">
        <location>
            <begin position="101"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="6">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW33842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="469" mass="52652" checksum="74288BD9C5FE795E" modified="2021-04-07" version="1">MFQNADEVQKYVADNDVKFIDVRFCDLPGVMQHFTIPAATFDPAEELAFDGSSIRGFQAIHESDMALRADLSTARVDPFRRDKTVNINFFIHDPITGEQYSRDPRNIAKKAEAYLASTGFADTAYFGPEAEFYVFDNVRFQTSANESFYHIDSEAGAWNTGSEENNRGYKVRYKGGYFPVPPVDHFADLRAEISLELDKNGLQVERQHHEVGTAGQAEINYKFNTLLAAADDLMLFKYIVKNVAWRNGKTATFMPKPIFGDNGSGMHVHQSLWQGGTPLFYDEQGYAGLSDMARYYIGGILKHAPSLLAFTNPTVNSYHRLVPGFEAPVNMVYSQRNRSAAMRIPITGSNPKAKRVEFRAPDPSSNPYLAFSALLMAGLDGVKNKIEPAEPIDKDLYELAPEEHANVQQVPTSLPAVLDALEADNEYLQAGGVFTSDLIETWIDYKRTNEIAPIQLRPHPHEFELYFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP50</accession>
    <name>A0A7K2ZP50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_33515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001540">
        <property type="protein sequence ID" value="MYW34058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="17618" checksum="B2F401E6A0980F81" modified="2021-04-07" version="1">MPTEPSPDASAVHQRGLLDTNIMILRKWISPAELPAEVGITTITLAELSAGPHEVRRNDEQSDYDEHAERGRRLDVLQRAESEFDPIPFDVEAARVYGRVCAAVISVGRKPRRRVADLMIASIAIAEGLPLFTTNPDGFKGLDELLTVVPVTRPAVLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPC5</accession>
    <name>A0A7K2ZPC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF309 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001556">
        <property type="protein sequence ID" value="MYW34187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="105" mass="11534" checksum="34A655645CA0B155" modified="2021-04-07" version="1" fragment="single">MNETRRDRDAEGRARNARPRDGLGRPLPYGTPGVERQPEGVVRTPHETLREAQRLLDAGMPFHAHEVFEDAWKSGPSSERELWRGLAQVAVGLTHAARGNTAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPH6</accession>
    <name>A0A7K2ZPH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001556">
        <property type="protein sequence ID" value="MYW34188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="6"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="884" mass="95050" checksum="EB4649595D90B281" modified="2021-04-07" version="1">MKPSRPLYEREPELAAAAKAVDDLCGAQAVGGLLVFSGEAGLGKTALLAEIRAMAADRCTIWSARGGETVTSVPFHVVRQLLQPALDQFPPDEKRALFDDWYDTTAPALGLAEPSGPQPDPQGVRDGLDYVVSRLASRLSHRPLLLLVDDAHWADGESLTWLSSFTARLGELPLLVVQAYRPQEMAERNASYVADREAERGSDGQSAVTRVALRALTPDATAELARAALGEHADDPFCREVWAVTGGNPYEAVELVAKVQDQELAPVEESAGQLRELGASARGSGLVARLERLGTNANRFAWAAAVLGTDISQELAATLAGMSSAEAADCTARLRDARIVSGFDPLEFVHPLIATAVYRSIPPATRTAMHGRAAWAITRAGLGAAAASRHLLEVHPDDDQELVAQLREAAGQHLAVGAPEAARRCLERALEEPPRPKDRAVLLYELGCATLLSSPPTTVQHLRAALDMPGLDDGLRVDATFRLAAALAHNNQLKDAALSLAAEAARTAPGPGLMRLQAAHFMWEGMQATEDDGPARSRRLTRNADHLKGRDNSERALLTLRAFDAMLRGENAQLIVDLCERALIDGSPARGLGWTDSEWGFELPTMVGITYTFTDQLDRAESLFGEAVRAFEISGWSGAHLAFAHTLLGMVHRRRGRLAEAEGFLREGLRLADRVGSGLPVHWDAACLLIDTLLARGRTAEARKIADRYHFGPPYPSAMVLPDGPSILGRLLLAEGRKEEAIAELEAAGAALEPRERFNGIWAPWAGDLARALAEDDPGRAAHLAARARVHAERFGTETAIGEALRCVSLFAPPEEAEQLLADAVRHLERSSSAYEHALARVDYGIAIGSHRELARAQKQAMACGAEGLAARAQKARTSIRSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPI1</accession>
    <name>A0A7K2ZPI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_34520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001585">
        <property type="protein sequence ID" value="MYW34253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="29"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="504" mass="53343" checksum="F4F21F40D67234A3" modified="2021-04-07" version="1">MSNGFQVQDRFAEGAQYIGGKLLPGTSGRHHDVVNPATGESVLRYELAGTDDVDAAVAAARAAFPGWSATTPGERSEALHRFAAVLAGQADDFAYAESLQCGKPVKLSTEFDVPGTVDNAAFFAGAARHLEGKAAAEYDGDHTSYVRREAIGVVGSIAPWNYPLQMAAWKILPAVAAGNTIVLKPAELTPLTSLMFAQAATEAGIPDGVINIVTGAGKDAGEHLVGHPDVVMTSFTGSTAVGKRVAEIATATVKRLHLELGGKAPFVVFDDADLEAAVHGAVAGSLINTGQDCTAATRAYVQRPLYDAFVRDVAALMETVRLGDPFAATTDLGPLISHAQRDRVAAFVERARGYAQVVTGGEAPGGDLADGAYYRPTLVAGAAQDSEIVQSEIFGPVLVVLPFDTDDEGIALANDTPYGLAASAWTRDLYRANRATREIQAGCVWVNDHIPILSEMPHGGYKASGFGKDMSAYSFEEYTQVKHVMYDNTAVARKDWHRTIFGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPJ5</accession>
    <name>A0A7K2ZPJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001589">
        <property type="protein sequence ID" value="MYW34291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="360" mass="38138" checksum="55DD96D47CE74A72" modified="2021-04-07" version="1">GPPEAAATVARDRLHAAWLGRAAGCLLGKPVEKLPLYGIRALARATGNWPLTTWFTARGVPDGLLAAHPWNRRSAPTSLAENIDGMPEDDDLNYPLLTLLLLQRHGRSFTTADLARLWLDELPAGRTFTAERIAYGNLLAGVEPPRTARLRNPFREWIGAQIRADVHGWTHPGDPAGAAAQAHRDAVLTHTANGVYGAMFTAAALAVAAGGESDVHGCLAAGLRVVPPHSRYAGAVRLGIETARAEREFDTVVDRLHAAYADTHHWVHVLPNAALLAAALTHADGDFTRSIGCAVSGGWDTDSTGATAGSLAGLLAGTPTALPDHWTAPLKNRLATSVPGYDRTGFDTLAALTHQEALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPL1</accession>
    <name>A0A7K2ZPL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ORF">GT040_34815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001591">
        <property type="protein sequence ID" value="MYW34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512251.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001591.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="239" mass="25309" checksum="741BD89372843EA1" modified="2021-04-07" version="1">MSRSVLVTGGNRGIGLAIARAFADNGDQVAITYRSGEPPQSLTEAGVLAVRCDITDAEQVEQAYKEIEEKHGPVEVLVANAGITKDQLLMRMSEEDFTSVVDTNLTGTFRVVKRANRGMLRAKKGRVVLISSVVGLLGSAGQANYAASKAGLVGFARSLARELGSRNITFNVVAPGFVDTDMTQVLTEEQRKGIVSQVPLGRYARPEEIAAAVRFLASDDASYITGAVIPVDGGLGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQC1</accession>
    <name>A0A7K2ZQC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_35940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001633">
        <property type="protein sequence ID" value="MYW34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="151"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="388" mass="41558" checksum="B9DFD8B9346D8415" modified="2021-04-07" version="1">PAAYRSEAAGYAAVAAMLAETVDAGRTVEAHRLGARRVALSDRRITEWTAWERYTLFLRSVLFPVINATYVTILGAVLLLGGWFVLEGWLTVGQLTTGALLAQMMVDPIGLILRWYDELQVAQVSLARLVGVREIEPDAGDAAVGPDGRDVRADEVRFGYREGVDVLHQVSLDVAPGTRLALVGPSGAGKSTLGRLLAGIYAPRTGEVTLGGAELSRMTAERVREHVALVNQEHHVFVGSLRDNLLLARDGAQDAELWASLAAVDADGWAKGLDKGLDTEVGSGGFALTPAQAQQIALARLVLADPHTLVLDEATSLLDPRAARHLERSLARVLEGRTVVAIAHRLHTAHDADVIAVVEDGRISELGNHDELVAADGAYAALWRSWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQL7</accession>
    <name>A0A7K2ZQL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit NuoE</fullName>
            <ecNumber evidence="8">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nuoE</name>
        <name evidence="8" type="ORF">GT040_36635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001675">
        <property type="protein sequence ID" value="MYW34660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="278" mass="29465" checksum="14BA57A88FD0FE24" modified="2021-04-07" version="1">MPQLPAPAYPADVRARLDADAKEVIARYPGSRSALLPLLHLVQSEEGYVSRTGMAFCAETLDLTTAEVTAVATFYSMYRRKPSGDYQVGVCTNTLCAVMGGDAIFDTLKEHLGVGNNETTDDGKVTLEHIECNAACDFAPVVMVNWEFFDNQTPESATQLVDDLIAGRTVEPTRGAPLCSYKETARILAGFPDERPGAVEATGGAGPASLIGLKLAKGEALPKARVVSPRDGQPKDGQPDAQVHDPSPTERLSSHDAPQQTSASDPEHSAGPAAEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQN1</accession>
    <name>A0A7K2ZQN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001661">
        <property type="protein sequence ID" value="MYW34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046295">
        <property type="entry name" value="DUF6332"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19857">
        <property type="entry name" value="DUF6332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="104" mass="10965" checksum="11D9421FC6740B63" modified="2021-04-07" version="1">MGERRTQAERDAMTVEIGYALVSSAVLAALTFAAASAPALLLFDLGRTARTVVLSIATAAAVLAFVARVVHVLWRFPRREGRRLDGRAPAPDRAGRSGSADSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQT4</accession>
    <name>A0A7K2ZQT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfi</name>
        <name evidence="2" type="ORF">GT040_36820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001679">
        <property type="protein sequence ID" value="MYW34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="24561" checksum="57C03D33859039C9" modified="2021-04-07" version="1">MTTQPTPAHETPADEAEGRAIQDRLRGLVVLDEPGPAPGTGLVTGVDVAYDEEKDVVVAAAVVLDAETLETVDEATAVGKITFPYVPGLLAFREMPAVLEALESLTVDPGVVICDGYGLAHPRRFGLASHLGVLTGLPVIGVGKNPFTFTYEAPGPRRGDFSPLVDGDEVVGRALRTQENTNPVFVSVGHRISLDNACAHTLRLARRFRQPESTRRADALCRQTLREATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQZ0</accession>
    <name>A0A7K2ZQZ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="4" type="ORF">GT040_37320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001688">
        <property type="protein sequence ID" value="MYW34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="15204" checksum="AA1E83E9F73266CD" modified="2021-04-07" version="1">MTQRTLVLLKPDAVRRGLIGEIVGRIERKAEWRITALELRTLDHDTLEQHYGEHKGRPFYEPLMEFMASGPVVALVAEGERVIEGIRTLAGPTDPIAAAPGSIRGDFGTITRENLIHASDSQESAERELKLFFPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR84</accession>
    <name>A0A7K2ZR84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001715">
        <property type="protein sequence ID" value="MYW34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="18472" checksum="C48873D29BAD08FA" modified="2021-04-07" version="1" fragment="single">PDEGLRPTVAAAAQALLHARRDLGVDELTDALVATPHTRAGELLSALAEDEPTALCRAVERWARDEDRPARRSAAARYAGLLQPRITADGDRTLLRSAAEILLARPEDRELHAAALTLLVRDPKSRGRHLPQALRLFAHGDPRLPLELLTEVFPLHPEPVLAALRARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRJ3</accession>
    <name>A0A7K2ZRJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001741">
        <property type="protein sequence ID" value="MYW35001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="16243" checksum="A375CEDDD5B32547" modified="2021-04-07" version="1">RSRIQRRDGDDVAGQSQPTEADSRATALAVFTSLTMGTVKELFARRAARREDLTTLFDRVVKAVTGEVLTVALKEAEQGCGSITTVIEDLLVEQREEVDRDRHDLRLALELSPAERAERLAATTLSLRELGELAGRLAVVRERWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRP6</accession>
    <name>A0A7K2ZRP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001733">
        <property type="protein sequence ID" value="MYW34968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="44" mass="4250" checksum="A1CDBBF051B9F978" modified="2021-04-07" version="1" fragment="single">MPDSPAAARRSLVPLSAALALATGMGTWYVLDGGPLTAPGGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRX2</accession>
    <name>A0A7K2ZRX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-containing redox enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001772">
        <property type="protein sequence ID" value="MYW35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="763" mass="82561" checksum="88EBDBCD8ACF6954" modified="2021-04-07" version="1">MHSQQAAATATLSAECQAGRPHGLPGDGGGSARTVYAYATDPEASLPEGRFIEEVRTVLRRHATGAGDGPPEVLDALARQAADWGTAERERYLTLAGGEEGPEGHREVLVRRAVLGCAPLALLSGAWLQWLSAPGNADAPLVLRILALYASDVGAGHPAASRGSAYLELLRRLRLAENAAPAARLTGDQRIPDGAFRLPALLLAMSRRPDDFRGEILGADLCLRAVGLLPALKLVQEVLPTEADWATLDPGGRREGEGPSPVERCRAAVDALVEQEGEWGADAVRTGFRWMLAGLRDWSGALHAELVAAGDPAFDMAELMRLRAREGAVYHHQFLLEDKPLARWLAECRTDPGPLLDVLARSKLVKPGRSGASSLVRGLVGERGPMFRVFSPEDLTVIRRWIDSLPVKPAEASESRTEPQTEPEPGPGPEGVRGGDVPEKPSPGATRDPLTAIAASLRAGARSPGRTPSGLREAYHLLMNRTDTPALRSWAMDYVAGWLARSGHGMDRTAMPLPERWGHEGLRPWLQSQHDQHGAEFEENAAVPLPSKEAVVDDTVQTAPLTLIDGSWLQGFTDYEQASSAIGHSLFETYWDELGNGEPHLNHPLIYRDVLKEMGVELPPTASAAFAQWPGFREESLELPVYWLCVGRFPQTFLPEVLGLNLAMELSGVGGTYRRARLALKAYGFSTRFVDIHNTIDNVATGHSAWAADAVDTLLASLPDAPGPGARADMWGRVRVGYRSLNPPRTVGARLAARRTRFTGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSS8</accession>
    <name>A0A7K2ZSS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001851">
        <property type="protein sequence ID" value="MYW35431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9649" checksum="B4DCEED9842B473F" modified="2021-04-07" version="1">MTCTCAEGFTVQLHDGGTRYPVIPTSEHSEISYYFDARCVGCRTKYGAPFARVDGEGQLLADQMQDVPLVDRLWFSKQCGPFTCGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZST1</accession>
    <name>A0A7K2ZST1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_11035</name>
        <name evidence="5" type="ORF">GT040_40665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000500">
        <property type="protein sequence ID" value="MYW29802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001848">
        <property type="protein sequence ID" value="MYW35416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7722" checksum="66C40365CA92B5B2" modified="2021-04-07" version="1" fragment="single">MSLRIVVCVKYVPDATGDRHFADDLTLDREDVDGLLSELDEYAVEQALQIADAADDAEITVVTVGPEDAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5W2</accession>
    <name>A0A7K2Z5W2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_00200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000003">
        <property type="protein sequence ID" value="MYW27731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="77"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="362"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="690"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW27731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="744" mass="79373" checksum="3EA5D1EF28025D71" modified="2021-04-07" version="1">MPKKRSGGGLTTTQQAAKFLGVAALSGAVLAGIALPAAGALGLAAKGTVEGFDEIPSNLKTPPLSQRTTILDRDGGAIATVYSRDRTVVPLKDISPYMQDAIIAIEDSRFYEHGAVDLKGILRAMNRNVQTGGTAQGASTLTQQYVKNVFVEEAGDDQEKVAQATQQTLGRKVRELKYAIQVEEELGKKKILENYLNITFFGQQAYGVEAASQRYFSKHAKDLKVEEAALLAGIVQSPTRYDPVNDTEEATKRRNTVLTRMAATRAITQAEADKAMETPIKLKVSKPKNGCITAVSGSGFFCDYVRKTILTDPAFGKTEEERSKLWNLGGLTVRTTLDPRAQQAANEAATAKVNKDDKFAASVVQVQPGSGKILSMGQSRPYGLDQKQNETVLNLAVSNRMGGSTYGFQVGSTFKPFTAAAALEKGITPATSFSTDWKMTLKEQDFRNCTGSPAGYADWPLQNELESEKGSWDMTSALGKSINTYFALLEQKAGLCETVEMAKKLGYERGDGKKIVEAPSITLGSEVSTPLSMAAAYAGFANRGTYCTPIAIESITDPNGKKLRVPQTKCSRAMSEKTADTVNQMLKGVVEDGTGTQAGLSDRDNAGKTGTTNDRKDAWFVGYTPNLSTAVWVGDDVGEKSSMFNVTIGGQYYDKVCGGCLPGPIWRIAMTGALNASETPAFNPVSVPRAKPKGDKEKEDGDRDGDRGGDEDREDGKPGRIQLPGGLIGGGGGGDQQGGGRSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z677</accession>
    <name>A0A7K2Z677_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">mscL</name>
        <name evidence="12" type="ORF">GT040_00815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000029">
        <property type="protein sequence ID" value="MYW27847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW27847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="18506" checksum="0F2FAB4707D38327" modified="2021-04-07" version="1">MSEKKVSLLEGFKAFLMRGNVIDLAVAVVIGAAFTNIVNAVVKGIINPLVGAFGTQDLDNYSSCLQGPCTTDPATGEMDGIEILWGSVLSATLSFLITAAVVYFLMVLPMAKYLARRAAMQAAKEGVQETLEVSELEVLKEIRDALVAQRGGGAADAGGFGAGGPGEGGGARPGRDGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6E1</accession>
    <name>A0A7K2Z6E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_01165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000056">
        <property type="protein sequence ID" value="MYW27917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029606859" evidence="6">
        <location>
            <begin position="28"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="146"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW27917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="396" mass="40010" checksum="8426F303E0CB2D1E" modified="2021-04-07" version="1">MRLRARWAPAALLLIAPLIGTTTPAAADTGPEGVPVERSARAVPGQYIVTLEPELSPDTVLEEFGLRPLFTYGNVLHGFAVTLTATELEAVRAVPGVLAVEENAEVAVETPRAGGLFRAPAATWGTDRIDQRALPLDDTFTTTATGDGVKVYVVDTGIEAGHAEFGSRVVKGYDAVGDGRDGQDCNGHGTHVAGTVGGSVSGVAKDASLVGVRVLNCQGRGTWAGIIAGFDWVAKDAAGSTTPAVLNASLGGARSRAVDAAVEAVADAGVLPVVAAGNEDQDACDVSPAAADGVVTVGASDRQDRETAFSNWGSCVSLYAPGADIVSAKLGGGTVSLNGTSMASPHVAGVAALYKQDNPSATPAAVTRRLTDTATPDVLSGLGQGSPDLLLYTGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6I4</accession>
    <name>A0A7K2Z6I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000059">
        <property type="protein sequence ID" value="MYW27951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="305" mass="31748" checksum="10D642F5726615C4" modified="2021-04-07" version="1">MGNFLAGKVVAVTGAGRGIGRAVALAAAAEGARVVVNDYGVSVEGSEPTSEIARSVVEEIEAAGGQAVAVADDISTMAGGQRIVDTALAEYGRLDGVVCVAGILRERMLFNMSEEEWDPVLATHLKGTFTVFRAASAVMRKQEGGGTLIGFTSGNHQGSVSQANYSAAKGGIISLVRSAALGLHRYGVTANAVAPVARTRMSAGVPMELSEIGEPEDVAALVVYLLSERARAERITGQVYTIAGPKIAVWAQPRELRAGYAEGAPWTPERIAEFLPGTVGTDPMPMLARVEEMAAAARRGARPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6L9</accession>
    <name>A0A7K2Z6L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_01500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000064">
        <property type="protein sequence ID" value="MYW27980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029832174" evidence="6">
        <location>
            <begin position="28"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="98"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW27980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="33663" checksum="E3962DD1C5243B03" modified="2021-04-07" version="1">MARMTGRRALFAVPVLLTVTFGVFAVAAASPFDPVKAYAGTAGLTASQENLDQIRANLGVDQPLVTRWWNWLTSALQGDFGDSSVMRQPVADVIVERMGWSALLAASAFLIAILLGTALGVLAARRPGGWLDRGVSSAAYTLEAAPVFWLGLLAIWLFALKLDVLPAGGLTDAGSDVVTFGQVASHLVLPAAVLGISQLPWFFLYVRQGVTDALAEDPVRGARARGLSERTVLLGHALRSGMLPMLTLIGSRVPELITGALLIETVFSWPGIAAATVEAATSVDFSLLAALTVLATAAVLLGNLLSDLLYGLADPRVAFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z778</accession>
    <name>A0A7K2Z778_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000116">
        <property type="protein sequence ID" value="MYW28210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="7397" checksum="B9D8493B736B9F7F" modified="2021-04-07" version="1">MNHRFLIFNPHRNSAWTSNNQERHVRTALARGRRWGVKVMVWENVDGDWRLIEDPDTYFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z798</accession>
    <name>A0A7K2Z798_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000120">
        <property type="protein sequence ID" value="MYW28230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="45" mass="4952" checksum="20A421B03CA3C968" modified="2021-04-07" version="1" fragment="single">MRELGTLAHRLRLHHPPETPCTCRPPQLLADRPDGTVVRSGPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7E7</accession>
    <name>A0A7K2Z7E7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_03065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000144">
        <property type="protein sequence ID" value="MYW28280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="456"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="530" mass="55348" checksum="BC14D2B52015DDA8" modified="2021-04-07" version="1">MSSKPVVLIAEELSPATVDALGPDFEIRHCNGADRAELLPAIADVDAILVRSATKVDAEAIAAAKKLRVVARAGVGLDNVDVSSATKAGVMVVNAPTSNIVTAAELACGLLVATARNIPQANTALKNGEWKRSKYTGVELSEKVLGVVGLGRIGVLVAQRMSAFGMKIVAYDPYVQPARAAQMGVKLLSLDELLEVADFITVHLPKTPETLGLIGDEALHKVKPSVRIVNAARGGIVDEEALYSALKEGRVAGAGLDVYAKEPCTDSPLFQFDQVVCTPHLGASTDEAQEKAGIAVAKSVRLALAGELVPDAVNVQGGVIAEDVRPGLPLAEKLGRIFTALAGEVAARLDVEVYGEITQHDVKVLELSALKGVFEDVVDETVSYVNAPLFAQERGVEVRLTTSSESPDHRNVVTVRGTLSSGEEVAVSGTLAGPKHLQKIVAIGEHDVDLALADHMVVLRYQDRPGVVGAVGKILGEAGLNIAGMQVSRAAEGGEALVVLTVDETVPQPVLTEIADEIGASSARSVNLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7H5</accession>
    <name>A0A7K2Z7H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="6518" checksum="7C8770E700FD1A26" modified="2021-04-07" version="1">MARLQAMPLPPDGTPFILVVDEVNEADFGEPWWADALQNLKDQTGARFLLATTTTMDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z849</accession>
    <name>A0A7K2Z849_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_04400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000198">
        <property type="protein sequence ID" value="MYW28529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="234" mass="25767" checksum="096EC7A6FEFE4D79" modified="2021-04-07" version="1">MVTLQSRKLVSPTENLRDQVAHALRAALIAGEIKPGGVYSAPALAAEFGVSPTPVREAMLDLAHEGLVEVVRNKGFRVTEMTERDLDEYTEIRTLIEVPTVGKVVRTATRDQLEALRPGAEAIVAAARGHDLIGYLDADRRFHLDLLALGGNRHLVSVVGDLRKRSRLYGLTELDEAGVLVDSAEEHVTLLDLMIAQDAEAAEALMRHHLEHVRTLWASRPQPEKRSALTLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9H5</accession>
    <name>A0A7K2Z9H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_06955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000312">
        <property type="protein sequence ID" value="MYW29020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029650805" evidence="3">
        <location>
            <begin position="37"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="22555" checksum="74FBD0BD0BE95B8F" modified="2021-04-07" version="1">MSRRRRLRTRRTLPRVSACAGAAVLLTTGFVSAASAAPADRTEPRTGTAVLAIPAIGVEDLDVVPYEGTTDDVPGSRIQDRGVASSPYGGNGGVGPGDVGNYLVTAHRLSAGGVLRDLPDLGKGAPVYVVEDGTRYTYEITATRQTSFRSERSLAEQRAEVPGRPGAEPTRAMITISTCATPEDDAAGNFWRDGLGNPEHRIDKVGVLVAESPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9I4</accession>
    <name>A0A7K2Z9I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_06820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidinotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000305">
        <property type="protein sequence ID" value="MYW28994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015067">
        <property type="term" value="F:amidinotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033195">
        <property type="entry name" value="AmidinoTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10488">
        <property type="entry name" value="PTHR10488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633195-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="377" mass="42935" checksum="60055119FA56F722" modified="2021-04-07" version="1">MTTVERRPGAPAAEDTAPLVSPVSSHNEWDPLEEIIVGRLDDATIPSSHPVVSCNIPPWAARIQGLAAGRKYPRRLIEPAQQELDGFVSLLHSLGITVTRPDAVDHRRRFATPDWASRGFCNTCPRDSMLVIGDEIIETPMAWPCRYFETHSYRRILKDYFRRGARWTAAPKPQLTDELFEKDFRTPGADEPMRYILTEFEPVFDAADFVRAGRDLFVTRSNVTNGMGIEWLRRHLGPGYRIHEIESRCRTPMHIDTTFLVLAPGKALVNPDYIDVDRLPAVLDSWDILVAPEPEPVKELVLRTTSMCGKWLSMNILMVDETRVIAERHHTGMLRALERWGFEPIPCDLMHYAPFGGSFHCATLDVRRRGTLESYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9L8</accession>
    <name>A0A7K2Z9L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Primosome assembly protein PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_07025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000314">
        <property type="protein sequence ID" value="MYW29033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="5">
        <location>
            <begin position="60"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="18554" checksum="958A814EB4388D31" modified="2021-04-07" version="1" fragment="single">MSSENEQSADPGAGAAEPGAGAPEQLALIRETVRQAKVPRAKPRTWRGAALAKELPVARVLVNKGVLHLDQFFDYAVPEELDADAQPGVRVRVRFGAGRHNVQGGRREGGGLIDGFIVERRAESDYQGTLAALAYVVSPEPVLGPELLALSRAVADRYAGSLADVLQLAVPPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9R9</accession>
    <name>A0A7K2Z9R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_07290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000330">
        <property type="protein sequence ID" value="MYW29084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="85"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="355" mass="38861" checksum="50674FC689175DF3" modified="2021-04-07" version="1" fragment="single">MSERTSAAELSRGGPSGEPGAFGLRLQAFRRRAGLSQEAAALRAGISTRALRDIERGRVQRPQTRTIQHLAEVLELTGGELADLLAVTRTGPSRGAARPRLLILGPLALQRGRVPVPVTSPMLRRLLGLLALKHPEPSTQREITDTLWPSGPPSSHQSLIHTYVSQVRRLLDPGGPRTAPAPTVVRTPTGYLLQASRSQTDLGHFDELLAQAERLHRAPDPGAAYESLTQALRWWRGPVLADADPVLRQHPAAVVVNERRVKAVLLYADTALLLHRPEEAVPVLWSMVNTEPLHEGLHARLILTLGSCGEQAAALNVFSRLRDRLDKELGIAPSAEVREAHLRVLRQQLPRAQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA27</accession>
    <name>A0A7K2ZA27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000360">
        <property type="protein sequence ID" value="MYW29188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="304" mass="33774" checksum="97576CBFB92BF95B" modified="2021-04-07" version="1">MTPSAPSSARIRIGSAPDSWGVWFPDDPQQVPWRRFLDEVAEAGYAWIELGPYGYLPTDPARLTDETRSRGLTVSAGTVFTGLHHGPDVWDRTWAHVADIAELTRAMGAEHLVVIPSFWRDDKTGEVLEDRTLTPAQWRDLTTQTERLGREVRERYGLRIVVHPHADTHIDSEENVNRFLDATDPALVSLCLDTGHYAYCGGDSVKLIETYGERIGYLHLKQVDPEILAAVVADEVPFGPAVARGVMCEPPGGVPALEPVLDAARALDVDLFAIVEQDMYPCDPDKPLPIARRTREFLRSCGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAC3</accession>
    <name>A0A7K2ZAC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000389">
        <property type="protein sequence ID" value="MYW29310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="22219" checksum="3A2B93A5A3A8F018" modified="2021-04-07" version="1" fragment="single">LALPAGARRMFRLLGLMPGPDVSVNGAAALADTTSAAAAELLVTLTDAHLVRERAAGRFGLHDLVRSYARELAGAEEAHAARQRLFEWYLYHADAAARLLYPVEPAPGPCAGAASSAALVFSDHGEASEWLDSERENLSGAVPQAAGAGFTTLAWRLAESLHGFLSVGMYTGECLKVATAGLFAAVADGEPRAQAAAQLRRAECHWQPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAM5</accession>
    <name>A0A7K2ZAM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000392">
        <property type="protein sequence ID" value="MYW29315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="5886" checksum="3937E159DBE0F9E8" modified="2021-04-07" version="1">GAIGEAGGAPLAARVEERLALMSPLRTEVRAGSLGDGAVLRGALLTARDAAQDALFAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAT7</accession>
    <name>A0A7K2ZAT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="11" type="ORF">GT040_09210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000418">
        <property type="protein sequence ID" value="MYW29449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241021.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000418.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="173"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW29449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="28729" checksum="C8965E34638633BF" modified="2021-04-07" version="1">MSELSSAKKQADNVNTASSHTLLEGRLGYHLESALLVRALTHRSYAYENGGLPTNERLEFLGDSVLGLVVTDTLYRTHPDLPEGQLAKLRAAVVNSRALAEVGRGLELGSFIRLGRGEEGTGGRDKASILADTLEAVIGAVYLDQGLSAASELVHRLFDPLIDRSSNLGAGLDWKTSLQELTASESLGVPEYLVTETGPDHEKTFTAAARVGGVSYGTGTGRSKKEAEQQAAESAWREISAAAEARQAAEKSAADGGAADTPADPSPDTDAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAU6</accession>
    <name>A0A7K2ZAU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000409">
        <property type="protein sequence ID" value="MYW29395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="105" mass="11391" checksum="57A0B033D9B11BA2" modified="2021-04-07" version="1">QLSGGQQQRVAVARALAAQPEIIFGDEPTGNLDSRAGAEVLSFLRKSVDELGQTIVMVTHDPVAASYADRVLYLADGSIVDEMYNPTADQVLDRMKHFDARGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB45</accession>
    <name>A0A7K2ZB45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000449">
        <property type="protein sequence ID" value="MYW29532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="22119" checksum="02CC0BD9AC042E45" modified="2021-04-07" version="1">MGELILIRHGETEWSRSGQHTSWTDLPLTATGERQARALVPLLADRNIGLTLVSPSVRARRTAELAGLHAPRVTPELREWDYGGYEGITTQAIRRTRPFWNLWTDGVDPGSDEHPGESPADVGQRADQVLAGVRSAAEGIGSADIALVAHSHFLRVLTARYLGLTPAEGRLFQLATGAVSRLGTEHGRPVIAALNVALPESLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBD0</accession>
    <name>A0A7K2ZBD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_10095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000462">
        <property type="protein sequence ID" value="MYW29618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="522" mass="55242" checksum="247F2DC80F52A588" modified="2021-04-07" version="1">MAHDAVQDGEGGRPDGSAVSLKPNAIGFVDALVIGLNATSPAYSLAAVIGPIVALVGIYAPGVMFASFVPMLLIASAFYYLNKVDQDCGTTFSWVTRAMGPWAGWLGGWAITMTGVLVVGSLADVAVSFTLLAVGLDGWVANDFARQFLTVLLIIVMTGLCVIGTELSAKVQNVLILLQIAFLLVFVVVALYRVYAGTTGFDSIEPSVSWLDPFGAGGAALTGGLLLGVFIYWGWESAVNLTEETENSASAPGKAGLWSTVVLLVTYLSVAVAVVAFAGTAFLAENAGEEEFIFAQLAGDVLGGWDWILLLAVATSAIASTQTTIIPASRTALSMARRQALPRHFGHISPRFRTPDVSTWWVAGIAIAWYLVVNQISTNALFDSLTALSLLIAFYYALTGVACAVYYRRHLTESVRNFVLIGLGPVVGAGLLTWLLVRSVMDMSDPANSYSGASWFGLGPPLVIGIVISLVGVVLMVVWRLRDAVFWQERPGVADPELVHATTTKPTDGKPPGGQSTDGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBD2</accession>
    <name>A0A7K2ZBD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000474">
        <property type="protein sequence ID" value="MYW29666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="10187" checksum="57F31319628C18DA" modified="2021-04-07" version="1" fragment="single">MPTRDPAPAPASTPADQPCDLVTVPARQGLEAVDILRRGRDHEAVGPVLHNGACDTLGFIVPPGTADAWDVPGSACTRTDGRGLRLPTTPPAAGSGWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBE3</accession>
    <name>A0A7K2ZBE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000484">
        <property type="protein sequence ID" value="MYW29687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="7957" checksum="82E7FE2B87A8F583" modified="2021-04-07" version="1">MTHTTILIPAREIRRGDEFDLHRHTRTAAYDAVKTTHGSIRVAFTNGGEAYLPADHEIRVSRPTGEALCAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBH4</accession>
    <name>A0A7K2ZBH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="249" mass="26537" checksum="061BD68940084814" modified="2021-04-07" version="1">MSNEEDIESKVPKGAVVAATTSALIGVVATHYPVLAIPAAVAKDFADPMVERMLSRIGALRQQRAQAAISEAASEAGVSVSRLTSTIEESPELLTLMAQVVQAAAETPLEEKIVALGRSLGRGVRDQAAVDAEFVKVRGVTAIETFEVKLMEIIGSGDPRRVTEETAEGERRDNLSGWKREDIVAHHSEFATVLDALISRLTAQGMVRDLSYQTFGGGGERWALTPFGEECLSLLTAVPAPDPTPPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBL1</accession>
    <name>A0A7K2ZBL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="76" mass="7933" checksum="FB0C26458AB0DDC1" modified="2021-04-07" version="1" fragment="single">MTTVYTRVASPLGELLLVGESDGAAEGLRLVSLSVPGQKGGAVVQDGWLRAPELFAGVVAQLEAYFAGRATRFDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBS6</accession>
    <name>A0A7K2ZBS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_11060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000500">
        <property type="protein sequence ID" value="MYW29807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="359" mass="39366" checksum="195F9BF8AB5A032B" modified="2021-04-07" version="1">MADPANVRTDARRHHDPQVRGFASDNYAGAHPEVLAAIALANGGHQVAYGEDDYTGHLQRVMHSHFGPTAEAFPVFNGTGANVVALQALTDRWGAVICAESAHINVDEGGAPERMGGLKLLTVPTPDGKLTPELIDRQAYGWDDEHRAMPQVVSITQNTELGTVYTPDEIRAICDHAHGHGMKVHLDGARIANAAASLDVPMRTFTNTVGVDVLSFGGTKNGALFGEAVVVLNPDAVRAMKHLRKLSMQLASKMRFVSVQLEALLAKDLWLRNARHANAMAQRLAEGVRAIDGVEILYPVQANAVFARLPHAVSERLQKRFRFYFWDETAGDVRWMCSFDTREDDVDAFLQALKEEMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBV5</accession>
    <name>A0A7K2ZBV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000503">
        <property type="protein sequence ID" value="MYW29823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="35" mass="3437" checksum="9E3DB80F8D033B90" modified="2021-04-07" version="1" fragment="single">MTPPTTGRLCAGRVVAVTGAGRGLGRAHALAFAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC58</accession>
    <name>A0A7K2ZC58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Choline oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_11320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000512">
        <property type="protein sequence ID" value="MYW29855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="498" mass="54565" checksum="645A74216D408C3E" modified="2021-04-07" version="1">AARLTEDPDVTVCVLEAGPSDVGDDSILRLDRWMALLESGYDWDYPVEPQEYGNSFMRHARAKVLGGCSSHNSCIAFWAPAEDLDEWGALGCTGWSAADCFPLYKRLETNDAPGDHHGRSGPVTLRTVPADDPCGTALLEACAEAGIPTTPFNTGTTVVRGAHWFQINARRDGTRSSASVSYLHPVLGKRPNLELRTGLQAKRLLFDGEDGRRCAGVEYLEPDTVHSGRVYARREVVVACGAIDSPKLLMLSGIGPAGHLRETGIEVRVDSPGVGSHLQDHPEGVIMWEAKQPMVTTSTQWWEIGIFADTEPGLDRPDLMFHYGSVPFDLNTYRRGYPTSENAFCLTPNVTRARSRGTVRLRTRDFRDKPRVDPRYFTDEHDVRVMTYGLRLAREIVAKPPMAAWAGTELAPGAGATTDAELFDYIRETHNTVYHPAGTVRMGAADDPDSPLDPQLRVKGVTGLRVADASVMPVLTTANPCITTMMIGERCADLIKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC76</accession>
    <name>A0A7K2ZC76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000547">
        <property type="protein sequence ID" value="MYW29960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030565535.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000547.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045512">
        <property type="entry name" value="DUF6480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20088">
        <property type="entry name" value="DUF6480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6248" checksum="1F8FA27F128C596E" modified="2021-04-07" version="1">MAVLVNPPTETPPAEGSIGDAHEERPDGGVWEHPAVWIGLIVLGALLVAGFFVARVFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCB3</accession>
    <name>A0A7K2ZCB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000553">
        <property type="protein sequence ID" value="MYW29994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="143" mass="15544" checksum="D639D6ED0D66D33E" modified="2021-04-07" version="1">MNRMNDPYDMSEGVPSVEAFRRLRTDAGLSDKASEAVALALPNTWYGVILRYEGEPIGMGRIIGDGGTAFQIVDICVQPAHQGRGLGKRIMAALTEELERRAPATAYVSLIADGPARFLYEKFGFADTAGHDSIGMYRLMNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCG2</accession>
    <name>A0A7K2ZCG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000559">
        <property type="protein sequence ID" value="MYW30023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="15634" checksum="ECB735027B22936E" modified="2021-04-07" version="1">GPVAAVAVTAGDEGGGRSVAVADPHPTSPAEDAFFQHMTEKVTATDPTTRVGATVGMEEKAWGTHTVLELKNVKGPQKCTLVAVSKTGEEEVVTSWSVPQWGYGIEGSTHESAKNPLYVHGGAAMAREDIDRFEVRTFDGERLVEIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCI4</accession>
    <name>A0A7K2ZCI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000566">
        <property type="protein sequence ID" value="MYW30049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="104"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="32845" checksum="17D4AA55CA7217B3" modified="2021-04-07" version="1" fragment="single">MSRTSSAGAVRVIGQEADRAARLLHRAREARLAGERSTVAPRAEIDASWERVVRSGIDPEQSPESELLEAEEIEHRRHSTALGEVMPLLRAGLASIADAAQQIMVVTDVEGRVLWRQGNAGVLHRAHDICLEEGAAWAEGATGTNAIGTALAARAPIQVHSAEHFIRALHNWTCAAAPVRDPRDGRLVGIVDISGPASTFHPATLALVDSVARLAEGEIRTRHLVAIERLRAVAAPILCRLGGRALAVDTHGWLAAVTGMPPVDRLPLPKSLVAGRVWLPSLGMCRVEPLPGGWLLQVSDSTAEGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCN8</accession>
    <name>A0A7K2ZCN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_12615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="462" mass="46766" checksum="9EE06340BC3FAD3C" modified="2021-04-07" version="1">MAQPATGPAEAPKPLIDTAVHPCDEKLPPARLVPAALQHIAAMYAGVVTPPLIIGQAVGLDTAGMTRLIAASLLIAGLATIVQTIGIGAFAGNRLPFVNAASSAGIAPMLAIAETSAPGHQLPAIYGAVLVAGVFCLTVGPFFGRLLRFFPPLVTGVVITLIGVTLMPVPVAWAQGGDATAADFGAMKYLALAAFTLVVILLVQRFGRGFLKQVALLFGMFVGTLAAIPFGLADFSALKSAPLAALPTPFAFGAPEFHPAAILSLCIVMLVLMTESSAGMLALGEICDRRTDGRTITRGLRTDGIATLLGPVFGGFPTSAFAQNVGVVSLTRVRSRYVVAAAGGALLVLGAFPVLGAVVSLVPMPVLGGAGIVLFGSIAVSGIRTLSEAGLDDSSNIILVAVALGAGIIPLAAPTFYAGFPAWAQTVLGSGISAGALVAVVLNLFFHHLGTHSRTAVALKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCU8</accession>
    <name>A0A7K2ZCU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000600">
        <property type="protein sequence ID" value="MYW30152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="164"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="38663" checksum="D883A7A029C595A0" modified="2021-04-07" version="1">MSDTSADSAGSDGNTSYGHKPFKRSRSHFADRITADGRDGWPVEPGRYRLVVSRACPWASRALVSRRLLGLEDALPLAVTDPIQDDRSWRFTLDPGDQDPVLGIRYLSEAYDARERDYPGGVSVPAIVDVPSGRLVTNDYQQITLDLATEWTALHRPGAPDLYPEPLRAEIDEVMEGIYRDINNGVYKAGFASSQQDYDEAYEALFARLDQVSARLADRRYLVGDTITEADIRLFTTLVRFDAVYHGHFKCNRTKITEDPVLWAYVRDLYQTPGFGDTVDFDHIKRHYYQVHTGINPTGIVPLGPDLSGWTTPHHREQLGGRPFGDGTPPGPVRDDERVTPVDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCZ3</accession>
    <name>A0A7K2ZCZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Export associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000610">
        <property type="protein sequence ID" value="MYW30213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="140" mass="15147" checksum="34A4B9D14AD42A1B" modified="2021-04-07" version="1">SVLAHLTRRVDLVQMAVRAGAADSLPPDLDTGEQLLVVNDFPHGFDDRAVTQLRYLADEGPAVGVHLLMVADREDASAYGPVLDPLWRSLLRITPVADSHLADPWVGHAWTYEPPVTPPGSRVLEQVLAAVMAARRAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDV6</accession>
    <name>A0A7K2ZDV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000703">
        <property type="protein sequence ID" value="MYW30512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12001" checksum="94FB18C1B2323708" modified="2021-04-07" version="1" fragment="single">TLNAFRHLRAEAALAEAAEADRRLAAGERLPLLGVPVAVKDDTDVAGLPTHFGCDGERPPATTDSEAVRRLRAAGAVIVGKTNSCELGQWPFTEGPAFGATRNPWNTAHTPGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDX6</accession>
    <name>A0A7K2ZDX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000715">
        <property type="protein sequence ID" value="MYW30563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="19084" checksum="CCE7EC67DFC523CC" modified="2021-04-07" version="1">MSGAAKILVVGPLGVGKTTLIGTVSEIEPLSTEASMTQAGVRVDADVDSGKRTTTVALDFGRLTIDGDLVLYLFGTPGQQRFLPAWQDLAKGALGALALVDTRDLAASFDALGNLEDLDLPFAVAVNVFPSGPRYDADDIRTALDLLPGTPLVICDARDRASSIRALIALVRHLIHVATESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEN7</accession>
    <name>A0A7K2ZEN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3105 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000758">
        <property type="protein sequence ID" value="MYW30769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="23781" checksum="5D06BFE13B112903" modified="2021-04-07" version="1">MSFGPGDPLYATPPQQPSDGARSTRNRAIAIGLSAAVVAGLAVFGTYMVLETSEAKENRSSGSAGQDDKPSGGDSGDTGGAIAGLKSWDGAELGRNHSAGDVDYPMTPPVGGDHNPSWLNCDGDVYEKAVPNVNAVHSLEHGAVWVTYSAKAAEGDVAKLAERVKSTPFTLMSPYAEQEGAITLSAWGKQVTVDSADDRRVDQFLAQYVQGPQTPEPGAPCTGGVETGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEP4</accession>
    <name>A0A7K2ZEP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000757">
        <property type="protein sequence ID" value="MYW30755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="23735" checksum="9CA11CB8AF3C4576" modified="2021-04-07" version="1">MADGWAVQRTGPGDQARTQAREQLLDAARELYGVVGYRETSEADLCEAAGVTPEALRQEYGTREGLLIALHNRVTTTGLRAMEAALLSEGMDECSIAERVRRLFDAYVESVTRDPREARVTFVEVLGVSAVVDEHCKLWRALWTEFLTGEAERAVERGEAEDRDHRVDVMVMVGTVHELMAHHTRRCRRARPEEVSGELTQLALTMLGSQPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZET6</accession>
    <name>A0A7K2ZET6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_16655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="41"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="202"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="33957" checksum="0BE45DFCC62D5EB8" modified="2021-04-07" version="1">MPAVTVDNPLTLPKVAASGDAVARPVLAVTTAPSGFEGEGFPVRRAFAGINYQHLDPFIMMDQMGEVEYAAGEPKGTPWHPHRGFETVTYLIDGSFIHQDSNGGGGTIENGDTQWMTAGSGLLHIEAPPESLVLSGGLFHGLQLWVNLPKADKMMNPRYQDIRGGEVQLLTSPDGGALIRVIAGELDGHQGPGITHTPITMIHATVRPGAEVTLPWREDFNGLAYVLAGRGSVGEERRPIRLGQTAVFGSGGSLTVRADEKQDGNTPDLEIVLLGGRPIREPMAHYGPFVMNSQAELKQAFEDFQAGRLGTVPAVHGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF37</accession>
    <name>A0A7K2ZF37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_16955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000797">
        <property type="protein sequence ID" value="MYW30919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="10882" checksum="04051715616F067F" modified="2021-04-07" version="1" fragment="single">AVVLLVAPGELGSVVQWLIGSTEGRVWQHWHLLWPWAAVWAAAAWLLSAPLTLLRCGDEQASAAGLDAGRGRAAALVCAVALTAGAVSAVGALGFVGLLVPHLALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFA8</accession>
    <name>A0A7K2ZFA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000821">
        <property type="protein sequence ID" value="MYW31040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="51"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="897" mass="97513" checksum="92D37EDAF064485A" modified="2021-04-07" version="1" fragment="single">MIARTESVAAPLAPYGMLQTVETRSVSPRFVGRAAELGALTEALARAGAGEPQALLIGGEAGVGKTRLVEEFAGRAARRDAVVAVGGCVEIGAEGLPYAPFPAALRALRRALPEEMAAASAGQEGELARLLPELGEAPRDATDEHSTARLFELTVRLLERISADRPVVLVLEDLHWADASTRHLLAYLFRTLGSGRLLVVGTYRADDIHRRHPLRPLLAELDRLRTVTRVELGRFSHDEVGSQLTSILAVTPGAAVVDEIFERSDGNAFFVEELARSMESSGDSSCLSASLRDLLLVRVEALPDHAQRLARIVAEGGSSVEHELLAAVAGLGDDDLEEALRAAVGANLLQPAPDSGGYRFRHSLVREAVSDDLLPGERTRLNRRYAEALEADPSLVREDERTTRLASYWYAAHDHAKALPAVLHAAVEARRRYAYAEQLRLLERAMELWDEVPDAVRETLRPFDFAEVYPASGDESATTPLRHLDVLAEATVAARFCGERSRALALCKKALRTPETEGDPLRAAWFWVQRSRLTQGLDRGDGWEELATAQELVRGLPPSAVHAEVLTHVASWRALHEPGPQALADSDRAVEYARLVGDEYIELHARLTRGWLTADAGGVEDGLAEMYAVRDRADERKLVHLVGRVSINLPSSLEAMGRSLEAVAAADHGIEVCHRHGLADSGAWVYANQAQSFFSLGHWARSECAAAAVERLALIPEPKGLAALRRTELALARGDFAEAEEQLALARKHFGRRDPQPQYQIPLARHAMLLAAALGRTAEAREVFEEVAARGFPTGTQRDALPLLQAAAAIEADARGLPATEPGRPAALDLIRRHARRLPLLVPVWAAHGLAIDAELARAEGADTPDHWARVAAAFAPLSRPYEVAQTHHRWAEALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFB8</accession>
    <name>A0A7K2ZFB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">prfB</name>
        <name evidence="6" type="ORF">GT040_17640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000825">
        <property type="protein sequence ID" value="MYW31054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030567842.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000825.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="368" mass="40970" checksum="F6650DE751F50B40" modified="2021-04-07" version="1">MAVVDISEELKSLSSTMGSIEAVLDLDALRADIAALEEQAAAPSLWDDPDAAQKITSKLSHLQAEVRKTETLRGRIDDLAVLFELAEDEGDAEALAEAETELESVRKALDEMEVRTLLSGEYDAREALVTVRAEAGGVDAADFAEKLQRMYLRWAERHNYKTEVYETAYAEEAGIKSTTFSVQVPYAYGTLSVEQGTHRLVRISPFDNQGRRQTSFAGVEVLPVVEQTDHIEIDESELRIDVYRSSGPGGQGVNTTDSAVRLTHLPTGIVVSCQNERSQIQNKASAMNVLQAKLLERRRQEEQAKMNALKGDGGNSWGNQMRSYVLHPYQMVKDLRTEFEMGNPEAVFNGEIDGFVEAGIRWRKQREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFC0</accession>
    <name>A0A7K2ZFC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000823">
        <property type="protein sequence ID" value="MYW31050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="180" mass="19136" checksum="AF72DB59BC20DCF1" modified="2021-04-07" version="1" fragment="single">MPLHVPSAPAPALRSVLAALGSPTAVRQARTSALRSVQGPLSPELPLPVHVLDRITPTGTAPRTRLAAWRFLIRSEGRAIAAADTMLTPDGWSFSHFFEGPYLASTELAVRQAEASPTAYQARLLSIPELYMLTLWLHDNPDDDAADASGVLAPADVLVPLAPAPPGIAAHRPHRVADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFR6</accession>
    <name>A0A7K2ZFR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold shock domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000863">
        <property type="protein sequence ID" value="MYW31203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="25" mass="2619" checksum="011D19A47511EA68" modified="2021-04-07" version="1" fragment="single">MATGTVKWFNAEKGFGFIEQDGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG16</accession>
    <name>A0A7K2ZG16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000884">
        <property type="protein sequence ID" value="MYW31304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076967473.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000884.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="16333" checksum="D9BF7C97E00338FD" modified="2021-04-07" version="1">MAEHTSSSITIEAAPADVMSVIADFARYPEWTGEVKEAEVLATDDQGRAEQVRLVLDAGAIKDDHVLKYTWLGDKEVSWTLVKSQMLRSLDGTYALASMAGGVRTEVTYKLAVDVKIPLLGMIKRKAEKVIIDRALAGLKKRVESMPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGI0</accession>
    <name>A0A7K2ZGI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IF2_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_19865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000925">
        <property type="protein sequence ID" value="MYW31471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF2_N" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="8783" checksum="DC11F5C0AF830605" modified="2021-04-07" version="1" fragment="single">MAKVRVYELAKEFGVESKVVMAKLQELGEFVRSASSTIEAPVVRKLTDALQGPGGNAGKSAAKPGAPRKATPAKPAAPSPAAAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGI2</accession>
    <name>A0A7K2ZGI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000924">
        <property type="protein sequence ID" value="MYW31464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="133" mass="14563" checksum="6B5E757B8D2DB01D" modified="2021-04-07" version="1">MSVLIDTVAWVRIEDGRILCARPKGKDVFYIPGGKREGAETDLETLLREIEEELTVGLIPETVVHAGTYEAHAHDGPGAPLVTMSCYYADYRGALAASSEIEEVAWFSYADRPLVPPVDQLLFDDLAAAGELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGQ4</accession>
    <name>A0A7K2ZGQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_20125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000938">
        <property type="protein sequence ID" value="MYW31520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029868442" evidence="3">
        <location>
            <begin position="26"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="186" mass="19498" checksum="739DD359A018DD93" modified="2021-04-07" version="1" fragment="single">MSGRLLRAVCATALATALAVSPATAAPAEPDPVPSEESVPPEDAPETDAAEVDAETALAAPEAAPEAGAPKSVATLLRGLQARYRAAEEASETYNATAEKLKQRTAQAKKVDAELAKARTALELSRGDAGRLAREQYQGRTEFSAYLQLLLARDPLRALDQSHVVERVAAGRAATVARLTADARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGS2</accession>
    <name>A0A7K2ZGS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000962">
        <property type="protein sequence ID" value="MYW31554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="26408" checksum="9C528FB8BB88A55E" modified="2021-04-07" version="1" fragment="single">RLCTVGDVAPGGVGRALGVADRTVRLGDTALTHRELGRAGLAVSGATVSPDGRLGAGKGVKAVTARGAAWTEPPLAALWETPSAEQAAHALRSVSRYAEPDGGGSDLLFLDVELLGSVGESGGTCLLARCDGGVSVRLAVADDDPALAHRDNLMLLATAPGTRLRIIGRLVPAPHPRLTLLACSHPTGESTVDLGFDRLSRADLPDPVAPVHSAPDRPGGPGAESPLHLLERRVEQTVPAGRAALGMLGDVTAEARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGX3</accession>
    <name>A0A7K2ZGX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_20600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000971">
        <property type="protein sequence ID" value="MYW31611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="5">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="16943" checksum="ED8341BB52BA86BE" modified="2021-04-07" version="1">DRAPLGDELLVQGEANPLFLVRYAYARTRALTRGAAALGFTSASDAAPAPYEAASDAAPAPHEAESDEASYESPARPLLDLLADHPRVLLAAARHRAPDRVARQLEAVAHAFFDFHDSCPPLPSGDEKPSAAHRSRLALAEAAGTVLAGGLSLLGIRAPAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGY0</accession>
    <name>A0A7K2ZGY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase subunit L</fullName>
            <ecNumber evidence="9">1.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_20415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000966">
        <property type="protein sequence ID" value="MYW31575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="132"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="666" mass="68314" checksum="A1DAD2449A236565" modified="2021-04-07" version="1">MTTTTLAALVPLLPFLGAVAGLALGRTAPGFVRPLAILPTLTAAVLAVLVAVRQGGGRAIDAATQLTPTGSVPIDLALHLDGFAVLVAALVTVVATCVQLYSTAYLRDDARYPSYAALVSLFTSAMLLVVYSGDLMVLLVGWEIMGICSYFLVGHYWETPEARAASLKAFLVTKLGDVPFLIGLFALAADTGSFRITKILAAVTNGGLDHPTLIALLLLAGVAGKSAQFPLHTWLPDAMAGPTPVSALIHAATMVAAGIYFVARLLPVFAASGAALVVLAVMAAVTMIGSGLAALAQDDIKRVLAYSTIGQLGYMSGALAVGDRGAAVFHLISHGAFKAVLFLAAGVVIHAAGTNSLAAMSRMGGLARRIPDAYWTMTVALLALAAIPPFAGFFSKEAVLVAAEHTAMGDRTVAPAAAGWTILVAGLLAAVLTAAYATRLWLLAFKGRGAEVPDHGRQPLAMTSVLWVLAVPTIAFGLTAGVIGDWFDGHALTPSLITAVLSTGVGLVGGLVTYGAWRHTTALAARTPIGAVAAHPGAEPALVEAEAMTSHTAAYGTIADAADPADPGRLLLGPLHRHAVTGFHLDALYTALFVRPVQQAARLVRFLDRTVVDTYVDGSGAATRLLGAAVRRAQTGNVQTYLSVLLAGSLVLAIAAVVFANVNAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH41</accession>
    <name>A0A7K2ZH41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000983">
        <property type="protein sequence ID" value="MYW31671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="341" mass="35588" checksum="2A178B99666A4210" modified="2021-04-07" version="1" fragment="single">MSSPSRDVSGLRGYAFDWALVDVETSGVIARRDRVLSVAVVTIGPDGKQTGEFSTLLNPGCDPGPVHVHGLTAERLLGAPTFEQVAGRIGALLQDRVMVAHNAQFDYDFLANEFARARMYLPVSQRLCTLALNRQVDPPAADMKLGTLAAHYGVPQTRAHDAVDDTRVLAGILRATLREAARLDLPLPLVACPPRQDVQFTPQPPKTPCAYRNPGRAEAGGPLVQGMKIAITGETATARAELVARSVAAGLNVMSSVSRHTSALVTNEAGSTSAKARRAAAEGVPVIDEHTFLRLLSDVRAGTPHRGAAEEAGASEGVASVSEAAAAVPGNADAAPASTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHD3</accession>
    <name>A0A7K2ZHD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH_GNAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="147"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="30959" checksum="3F6F090E0B0E83BB" modified="2021-04-07" version="1">MHSPSPLPLVDLPVRRLTRGDLVSCADLSEDRGWPRDEHRWGLLLSAGTGYGIAEPAGTGLVAACVVTSYGPRLAAVGMMLVAARHARQGIARRLMRHVMEETGSTPLALYATPEGQGLYEEFGFAQVGRTERVLGRFRAEDRPAAVTTRPAAADDLQAMVRLDLPVFGIDRTHLIARLPAFSDRLRVAEEDGELTGYAALWPSGDAHVVGPLIARDTATAKALVAALAATTDRPLRADVDARHEELLGWLVERGLEPGSRTAVMTYGIEDLPGDATRRFAPLTIATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHE7</accession>
    <name>A0A7K2ZHE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_20950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000984">
        <property type="protein sequence ID" value="MYW31679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="322" mass="35292" checksum="55AFBD38A5590169" modified="2021-04-07" version="1">MTDKFDKTPPGSPAGQVSVSKGATTAPENIKAIPVRHVGRWISGIVVIGLLVALGYAFSQGNIQWQAVGDKLFDKNVVAGAGRTLLISVLAMVLGVILGVILAVMRLSKNPVTSWVAWLYIWFFRGTPVYVQLLLWFNLALIFPVLNIPFIYKDEMTDVMTPFMCALLGLALNEAAYMAEICRAGIQSVDEGQTEASHALGMTQAKTMRRVVLPQALRVIIPPTGNEFINMLKTSSLVYAVTYNELLRSTSQIGSTSYAVMEMLFVASIWYIVMTSVFSVGQYYLERRFARGSLRSLPLTPLQRIKVNLASFSNRPSGGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHG4</accession>
    <name>A0A7K2ZHG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF805 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008523">
        <property type="entry name" value="DUF805"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34980">
        <property type="entry name" value="PTHR34980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05656">
        <property type="entry name" value="DUF805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="13215" checksum="937B5258FE38EFD0" modified="2021-04-07" version="1">MDWYLAVLKNYAGFSGRARRKEFWMFTLISFVISLVLSIIGSLIGTEILSYIYSLAILIPSLAVAVRRLHDTSRSGWWLLIGLIPLVGFIVLIVFFASEGKQEPNQYGTNPKLAPHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHS4</accession>
    <name>A0A7K2ZHS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001041">
        <property type="protein sequence ID" value="MYW31894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8556" checksum="850F0F0DEFA72E0F" modified="2021-04-07" version="1">LLRTRVADRAPRLAAGPGARAQGVRVSRDDATGAWHIDIRLVLHRGHRALDVTRAVQTATLAAVRDEPSVSVRVTVTGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHT6</accession>
    <name>A0A7K2ZHT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_22115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001042">
        <property type="protein sequence ID" value="MYW31897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="43"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="112"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="35501" checksum="B6BEB8742E62B2AB" modified="2021-04-07" version="1">MSGETRDAILLPAALERLARIADVQPDLLITDFGADDPVQRAALGEAEALFTGWGCPPLTADALSAMPRLRTVVHAAGSVKHHITQGVWDRGITVSTAATANALPVAEYTVAAILFANKHILESARVYRESRSRVNLLREFPAIGNYRRTVGIVGASRIGRRVAELLRPFDLRLLVHDPYLDEKSARALGAELTYLDALVAQSDVVTIHAPELPQTRHLFDAGRLALMRDGATLVNTARGSLVDTEALVKELVTGRLNAVLDHTEPEVLPAESPLYDLPNVLLTPHIAGSQGGELHRLADAAVDELERYAHGLPFAHAVDPRTLHQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI28</accession>
    <name>A0A7K2ZI28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">clpS</name>
        <name evidence="3" type="ORF">GT040_22700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001065">
        <property type="protein sequence ID" value="MYW32006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030567742.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001065.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="105" mass="11857" checksum="79D4B7E02DD57B2A" modified="2021-04-07" version="1">MGQVSVATPVEIERPDSAEETFAVPEPDVPWVTLVHNDPVNLMSYVTYVFQAYFGYSKDKAHKLMLDVHQKGRAVVSSGSREEMERDVQAMHGYGLWATLTQDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI80</accession>
    <name>A0A7K2ZI80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001072">
        <property type="protein sequence ID" value="MYW32047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="13892" checksum="4E922254E530FD54" modified="2021-04-07" version="1">MSTTTMERRELGRFLAVAGQQFADGGGPAEMFSRAVDAAWHQMLGTSGYEAFSTEHAGSVLGHREMSGFGPIGWVAAYEKAYGPLPAIWFTAADGVLDQGALARYKETGTVVAEWDCGPTTGDGDDAAPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIQ8</accession>
    <name>A0A7K2ZIQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001114">
        <property type="protein sequence ID" value="MYW32231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="109" mass="11662" checksum="5DF94E0B39C62453" modified="2021-04-07" version="1">MTTTLVEIHVPMLPTPDLPDDSYPWIDQVEDFLVDLEDEGGIEVHDEGEEHGDAYVFFVTGAADEELLAVASRVATLPGVPAGAFAVVSDAEAEEFGRGRRVALPLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIV3</accession>
    <name>A0A7K2ZIV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001127">
        <property type="protein sequence ID" value="MYW32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="217" mass="23974" checksum="CBD24D2A71234BFF" modified="2021-04-07" version="1">MTEACVILDIGGVLELTPDTGWVQRWEEQLDLAPGTVDERLRDVWEAGSVGSIGEPEVRGQVAARLALDAVRLEAFMGDLWAEYLGTPNEELMAYLRGIRRRCRLGILSNSFVGARERETALYRFDELVDEIVYSHEIGINKPDPRAFEAACAALGVRPEDCLFVDDVVINVEAARALGMRAHLYEDNARTIARIATHVEAGRALRGCAGRARRPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ50</accession>
    <name>A0A7K2ZJ50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_24660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001154">
        <property type="protein sequence ID" value="MYW32372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M4" evidence="9">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="10">
        <location>
            <begin position="123"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW32372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="295" mass="31403" checksum="3E27AE406B7C6EFE" modified="2021-04-07" version="1">TAGAVPAKPHRTLYDCENGTSLPGTKVRDEGDKPTSDASVNRAYAGLGATFELLLSAYGRSSIDGKGLPLIGSVHYGREYNNAFFDGEQMVFGDGDGEIFLDFTYAIDVIAHELAHGLTQYTANLRYEGQSGALNESVSDVFGSLVKQFSLGQSAEQADWLIGAGLLAPRVSGDALRSMKAPGTAYDDDVLGKDPQPASMEDYVETEEDNGGVHINSGIPNRAFYLLATALGGNAWERAGQIWFDVLTGGELTATADFEEFARLTVAAAGARFGERGEKEAVLKAWSEVGVRTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJF6</accession>
    <name>A0A7K2ZJF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_24745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001156">
        <property type="protein sequence ID" value="MYW32389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="400" mass="42254" checksum="891E514FB76AC1D0" modified="2021-04-07" version="1">MTRTAAAEPGPPVSTAPGPDTGGRRLPRTLHPLAWWIWALALATAVSRTNNPLLLFLVLAVLGYVITMRRTEAPWARGFKYYLYLALTVVAIRVVFRAVFATGMRPTDHHLFSLPHIPTPDWYAGIQLGGPVSLEALLSAATDGLRLACMLCCIGAANTLANPKRALRVLPGALYELGVAVTVSISVAPQLVQSVQRVARARRLRAGRNKGLKALRGIVVPVLEDALERSLRLAAAMDSRGYGRAGSATPGSRRLTGALMLLGMCGLCAGAYGLLDPTAPKLLGLPALAAGSALCLAGLRLGGRRVTRTTYRPDPWRFAEWAVASCGVLSAVLLFVNVGYDPAELNPSIYPLSWPTLPLVPAAAILLAGAAGFLAPPPSAPVPYVSAPGTRTRTRTEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJI1</accession>
    <name>A0A7K2ZJI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_25280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="31542" checksum="B30368F93B277A01" modified="2021-04-07" version="1">MSSTTETQALRPDRKKSRLHLDIIGLGIAAVMIFPVYWLVISSLRPNQEIRSYDQKLWPTSLTFDNFERAVNQPNFTTAIQSSLIVAVTAVVGGMIIATLAALAIGRFRFFGRKPLLLIMILVQMLPPTAMLIPIYAQLNAMGGIDEYWGLIVVYLVSTLPFATIMIRGFVVNIPVELEESAMVDGLTRFGAFRKVVFPLLAPGLAAASIFALVNAWNEYLFAYILINDNSKYTLNVWLMTFTTERGTDYGALMAASTMIALPVVIFFMIIQKKMAAGLTSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK05</accession>
    <name>A0A7K2ZK05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoacid:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001221">
        <property type="protein sequence ID" value="MYW32677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="69"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="357" mass="38432" checksum="C6EC3AEF4CA3BE05" modified="2021-04-07" version="1">MPDTQELLHNELLQLVPKAEAKQSMKDFKSDQEVRWCPGCGDYAVLAAVQGFMPELGLAKENITFVSGIGCSSRFPYYMNTYGMHSIHGRAPSIATGLATSRRDLSVWVVTGDGDALSIGGNHLIHALRRNVNLKILLFNNRIYGLTKGQYSPTSEVGKITKSTPMGSLDAPFNPVSLAIGAEASFVARTVDSDRKHLTSVLRAAAEHPGTALVEIYQNCNIFNDGAFEVLKDKEQAAEAVIRLEHGQPILFGAEGTKGVVRNQATGDLEVVAVTDENRSQVLVHDAHADSPTTAFALSRLADADTLHHTPIGVLRSVQRPVYDTLMSDQVDAAVERDGKGDLGALLAGADTWTVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK20</accession>
    <name>A0A7K2ZK20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase component I family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001224">
        <property type="protein sequence ID" value="MYW32691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="73"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="352" mass="37198" checksum="D3D2CB3C5CBF1900" modified="2021-04-07" version="1">MARFGGLVASGLQDVTHDPSALDSSGFWAVCADFEGRTVCARFSSVRREEVPAPVPGAWRGPAAGEWATSLDRDAYTAGVRRIREYIAAGEVYQANLCRVLSAPLPEAGPGRADVDALTALLARGNPAPYAGTIRLPGHGVEVATASPELFLRRDGRTVESGPIKGTGRTEADLLEKDHAENVMIVDLVRNDLGRVCATGSVTVPDLCVVEKHPGLVHLVSTVRGELAEGAGWPELLTAAFPPGSVTGAPKSSALRIIEELERAPRGPYCGAVGWVDADRGTASLAVGIRTFWIDRTGSAPLLRFGTGAGITWGSDPEREWDETELKASRLLAVASGTFEQTGFEQTGRTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKC8</accession>
    <name>A0A7K2ZKC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_26915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001254">
        <property type="protein sequence ID" value="MYW32806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="27874" checksum="05D35FA5314A56D2" modified="2021-04-07" version="1">MSLTDNGGLRAERVGREAGGRLILDGVDITPPPGATVGLLGPNGSGKSTLLRILAGLLAPDTGTVSLDGDPLAALGRRTVARRIAVVDQHAVTQVDLSVLDVVRLGRIPHRRAWSAPDRADEEAVTDALRRTGLTDRAAQSWHTLSGGERQRVQIARALAQQPRELLLDEPTNHLDIQHQLDLLALVAELPLTSVIALHDLNLAAMFCDRITVMKAGRVIGGGTPAEVITEELIEDVYGVQAVVTPDGPDGRPSVRFLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKF7</accession>
    <name>A0A7K2ZKF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_27035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001258">
        <property type="protein sequence ID" value="MYW32830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="262" mass="27824" checksum="5A3FEEC16251FAEC" modified="2021-04-07" version="1">MMRIDIDALTVETAGARLVDEVTLGAGEGQLVGLVGPNGSGKSTLLRCVYRALRPSSGTVRVGGDDFHALSTREGARRLAALPQDAVAEFDFTVAEIVAMGRMPHQGPMARVTGEDRDRCTEALDGVGAAHLAERGFLTLSGGERQRVLIARALAQQPRVLVLDEPTNHLDIAHQLEILALVRGSGLTVLTALHDLNLAALHCDLIHVIDGGRIVASGAPYDVLTTELLAEVFGVRAHRVAHPETGALQLLFDLPRARPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKH9</accession>
    <name>A0A7K2ZKH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_27080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001260">
        <property type="protein sequence ID" value="MYW32838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00238"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="88"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1148"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1438"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1537" mass="163111" checksum="1126DE58784A0B78" modified="2021-04-07" version="1" fragment="single">GSAAVQRVGSRPVATAPALAALRTAWGVDAAQLVLADLAPAEPRVDVPGTVAGAEASLPVPGAEPGAVSDAQPASLPVAEEAVTRTGSGTAALLRRLLAAALRLPPAEIPDDAPFLSLGLDSLAAVDLVRQLERELGISLPATLFFEYRTVRELAAHLDTPASPAPAAPAASSPVADGEPFPLTPVQLALHTSGRLHPDIPAHGYVRQTVQGPLDSQLLGRALTALAERHTMLRVRVEDRTDGNGTTAPRQYVAPPTALSAWYEVREDAGRIEDVESALRNRPFDLSAEPPVRAVLTRESPDLAHLTLVIHHVAGDGYSLNVLAEDLWSLYTALAHGQEPASEPSLPALGTDFARYSAAAAEERSSAAGAQALAADLRYWSERLADRGEALRLPYDGDPDALPTAPLATHGSALDAPLTAALEKRAAEHGVSLFHLLLAAHVRCLGRWSGQREVAVNVARARRDARLPGLDRLVGPLADTLPLLWESDPGESVWELAKRLGRVWLDSERHAAPTTLDLARLLPGRPTGAGPRTVSPAGFSFARFPAALDARCPVTVRPTAAGTGTPATRLSLLCWQDGEVLRFSWNFPVRLFAPETVVRLDRDFHDELAALVDTEAAHPEPECRSATIVERLLNQFRATPDAVAIDTGAETLTYGELDRASHALAARLLTHGVTPGSLVGLLTEPGADAVVSVVAVLRAGAGWVPLDSGHPTPRLADQLARSGARTVLCHAATRAAGEALGDVTLVSADRTEPAPQGSADELGGPVDGDSIAYVIFTSGSTGRPKAVPITYCSMENYLSWAIGTFGYDEHDRLAQTASLCFDASVRQLLAPLLVGATVVTVDRDLLRDPDLLLTHVERTRITVWSSVPTLWEQLLTASEERVRRGAPRPDLSFLRWIHVGGEALSPAHVRRWFDLFGSGQRIANLYGPTEATINTTCHIIGARPGDDVRQLPIGTPVAGTEVEIAGPDGEVRQLGEAGELLIAGVGLTAGYLGEPALTEAAFTNRRGRRWYRSGDRARVAEDGTLEFLGRLDDQVKVRGNRVEPGEIEAVLQAHPDIAQAVVLLQDGRLVAFVTPRAGVPVADAVALRLHLAGTLPPYMVPSRVTSVARMPLTGTGKIDRRRLVALPAGARTEGGDEAVGPADVSRSAPLTPTEVRLARIWSRLLQTDDVCREDDFFALGGDSLLVLEVFARLEKEGGPLPRPTVIYRHRTLAALAHAVDAAAADAADPSVTAVNPSVRDMGVAGAETGGAGPLPFPLTPTQRGFLLAEAIAPGEASSWLTRLRLHGPLDTARFQQAVDTLVVRHPMLRTVFPAGARPAVQQELPPSLRLPVDFETVTGRHGIEESTAAERTRRFEPWAWPLLRLRVLTLAPEDHVLLVHAHHIIGDGYSAALLIRELTTVYDALSRGEEPGLAPLRSTFRDHATRLSVRADATATTGAGADADAVTPAAATRDGSRRALLSAPYRPPVMSAGTGGSSGEAGRHAPFLTDGFTLGADQVEQLRGLASRTGATLYAPVLTAYYRALMAATGQEDLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKP7</accession>
    <name>A0A7K2ZKP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001295">
        <property type="protein sequence ID" value="MYW32921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="24609" checksum="881EEF3A170E3C84" modified="2021-04-07" version="1" fragment="single">MNLPALRHHNAALVLDLLRAAGAEGISRLELAERTGLTPQAVSKITARLRAEGLAVGAGLRPSTGGKPRTVLRLVPDAQFAVGLHLDRDGLTAVLVDLAGRPVAVTTAPLDFGAPAEQVLADAADAVRDLSAAEPHKPVLGLGVAVPGPLDHRDGVLHRVTGFPRWDGFPLRDALAERTGLPVTVDKDTNAAALALSLSGLPGDFAYLHLGTGLGAGLVLGGAVHRGARTGAGEFGHQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKX0</accession>
    <name>A0A7K2ZKX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_27920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001301">
        <property type="protein sequence ID" value="MYW32997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029671232" evidence="4">
        <location>
            <begin position="32"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="395" mass="40609" checksum="4770FB96A558E929" modified="2021-04-07" version="1">MSGCSHRFRPRGLCRGVTLTLVFGCVLATGAATGSLPQDPDPVPELPARTVASRHAPVDREEIEDAAAEAEADGKSVKDAAGEVVSRSGDRWGAVYDEQEYEEFEQALDGSYLGVGLSARRTAGGGVAVSRVQPGGPADRAGIREGDLLRTIDGRRVDKRPVPEVVALLRGDGTGAGEGTRVTLGLVREGKPSTRTLERARLTPDAVTVSRLGTGPSSALLVKVAAFTKGTGQEVRDAVRGAPGDAGILLDLRANSGGLVTEAVTAASAFLDGGLVATYDVRGEQQALYADPGGDTERPVVVLVDGGTMSAAELLTGALQDRGRAVTVGARTFGKGSVQMPSELPGGSVAELTVGHYRTPAGRGVEGRGITPDLVVRERAQQRAETVLSGLGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKX4</accession>
    <name>A0A7K2ZKX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001302">
        <property type="protein sequence ID" value="MYW33006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15895" checksum="EA90AE7E67A8F511" modified="2021-04-07" version="1">MALTREEREQFLAEPHVAALAVDAADEGRAPLTVPIWYQYAPGGDLWIMTGRDSRKGRLIAGAGRFSLMVDRVEPTVRYVSVEGPVVATLPATREHLVEISSRYLPAEKVDGYVDFAWREHGDQVVIQMRPQRWLSSDLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLL3</accession>
    <name>A0A7K2ZLL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L,D-transpeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_29195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001355">
        <property type="protein sequence ID" value="MYW33233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029621124" evidence="3">
        <location>
            <begin position="40"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="4">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="122"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="25746" checksum="4F32FC472FCD3A64" modified="2021-04-07" version="1">MGVMGHISGGRLRRGVALSVTGLVAAPALVLGTGTTAQAASCSTSTGPYQKQVEKFLKRPVDGKQSAADCKAIQKFQKAHGITPTIGYAGPVTWRTMNTMNAQKAAGKNPDKAGKCPTNKGRIACVDLTRQLSWIQDGKKLKYGPVPVRTGRDGAETRTGAKKIYWRNIKHWSTIYKVWMPHAQFFDGGQAFHSVTKSMYNPPGSGGCVNMRPADAKAYWKLLKNGDDVYVYGRKPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM04</accession>
    <name>A0A7K2ZM04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001385">
        <property type="protein sequence ID" value="MYW33366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="9349" checksum="02B9B9326639A1C2" modified="2021-04-07" version="1" fragment="single">HINYAFGNVQNGKCTIGDAYEDYEKSYTAANSVDGKADVWDQPLRGHFNQLRKLKAQYPHIKVLWSFGGWTWSGGFGQAVQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM56</accession>
    <name>A0A7K2ZM56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catalase</fullName>
            <ecNumber evidence="3">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="20739" checksum="CD07DAC6F10F00B9" modified="2021-04-07" version="1" fragment="single">MTDTSRKPTTSDSGAPVESDEHSLTVGPGGPILLQDSYLIEQMAQFNRERIPERQPHAKGSGAFGKFEVTSDVSAYTKAALFQPGTTTDLVARFSTVAGERGSPDTWRDPRGFAVKFYTSEGNYDMVGNNTPVFFVKDPMKFQHFIRSQKRRADNNLRDHDMQWDFWTLSPESAHQVTWLMGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM76</accession>
    <name>A0A7K2ZM76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001395">
        <property type="protein sequence ID" value="MYW33446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029667243" evidence="1">
        <location>
            <begin position="33"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="17321" checksum="BC4593EFBECB487E" modified="2021-04-07" version="1">MTDMDRRSILQLTSAATIAGGLVAGAGGAAHAARKAAGQIVLRGKRTGANIPDVLTAGVPYFVRYDLSDEQGRSVGTENAHCLPVAVGLDGSFVIATLVLSLDTGMITAATAFQRPLPAVTEPPVNARPWTHAFAITGGTGTYVGAAGSITIEHPTRDEDVLTVDLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMH7</accession>
    <name>A0A7K2ZMH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001422">
        <property type="protein sequence ID" value="MYW33532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_114" evidence="1">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7738" checksum="E88C2C21E442E925" modified="2021-04-07" version="1">GFDFAVAEECGRYDECADYATAYGNRVFVIEYTARDFSKACSAVGAKLSVVHRDLDVRPAGQKGYVFRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMU3</accession>
    <name>A0A7K2ZMU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001440">
        <property type="protein sequence ID" value="MYW33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="16747" checksum="CDE5DAAE79E471DB" modified="2021-04-07" version="1">MFRLETEVDKERHRLLGKRLHEDNVAASPGLRALLSTSAEHETPLEVWALDEQGTVAGGLTGRTWAYWLHVDLLWVDARHRSAGLGSQLLAEAERVARTERACTRSRLETWDFQAPDFYRKQGYEEIGRVEDYPPGVTEFILTKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMW1</accession>
    <name>A0A7K2ZMW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">metH</name>
        <name evidence="30" type="ORF">GT040_31330</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="WWKE01001437">
        <property type="protein sequence ID" value="MYW33638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 20 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="25">
        <location>
            <begin position="15"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="26">
        <location>
            <begin position="349"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="29">
        <location>
            <begin position="641"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="28">
        <location>
            <begin position="734"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="27">
        <location>
            <begin position="882"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="22">
        <location>
            <begin position="744"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="22">
        <location>
            <begin position="1167"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="792"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="850"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="932"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="MYW33638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1171" mass="127813" checksum="0CFB07ED69537CEA" modified="2021-04-07" version="1">MASLPTPAPDSRTRAAALREALATRVVVADGAMGTMLQAQDPTLEDFENLEGCNEILNITRPDIVRTVHEEYFAVGVDCVETNTFGANHSAANEYEIADRIFELSESGARIAREVADEFAEKDGRQRWVLGSIGPGTKLPSLGHITYDVLRDGYQKNAEGLLAGGSDALIVETTQDLLQTKSSIIGARRAMEALGIDVPLVCSLAFETTGVMLLGSEIGAALTALEPLGIDFIGLNCSTGPDEMSEHLRYLARHSRTPLMCMPNAGLPVLTKDGAHFPLGPDGLADSQETFVRDYGLSLIGGCCGTTPAHMKAVVDRVRGLTPPERDPRPEPGAASLYQHIPFRQDTAYLAIGERTNANGSKKFREAMLEARWDDCVEMARDQIREGAHMLDLCVDYVGRDGVADMAELAGRFATASTLPIVLDSTELPVLRAGLEKLGGRAVLNSVNYEDGDGPDSRFAQVSALASEHGAALIALTIDEEGQARTIEHKVAIAERLIEDLTTNWGIHESDILIDTLTFTICTGQEESRGDGIATIGAIRELKKRHPDVQTTLGLSNISFGLNPAARVVLNSVFLDECVKAGLDSAIVHASKILPIARLEEEQVKVALDLIYDRRAEGYDPLQKLMELFEGVNMKSMKAGKAEELMALPLNERLQRRIIDGEKNGLEADLDEALQDTPALDIVNNTLLEGMKVVGELFGSGQMQLPFVLQSAEVMKSAVAHLEPHMEKSDDEGKGTIVLATVRGDVHDIGKNLVDIILSNNGYNVVNLGIKQPVSAILEAAEEHRADVIGMSGLLVKSTVIMKENLQELNQRKMAADFPVILGGAALTRAYVEQDLHEIYEGEVRYARDAFEGLRLMDALIGVKRGVPGAALPELKQRRVPKKDVAAVLEVEEPEGSVRSDVSTTNAVPEPPFWGTRVIKGIPLKEYASWLDEGALFKGQWGLKQARTGDGPTYEELVETEGRPHLRGWLDHLQSNNLLEAAVVYGYFPCVSKGEDLILLHEDGSERTRFTFPRQRRGRRLCLADFFRPEESGETDVIGLQVVTVGSRIGEATAELFAANSYRDYLELHGLSVQLAEALAEYWHARVRSELGFAGEDPADVEDMFALKYRGARFSLGYGACPDLEDRAKIADLLQPGRIGVELSEEFQLHPEQSTDALVIHHPEAKYFNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMX0</accession>
    <name>A0A7K2ZMX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001446">
        <property type="protein sequence ID" value="MYW33714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="184"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="376" mass="38776" checksum="3CF59D6D4A85E28D" modified="2021-04-07" version="1" fragment="single">MRIRIVGAGAMGRGIAQWAASAGHTVELGDVRAEAVTDAVESVVSMLDRAVAKGRMSAAGRDATVARLVPLADPWGAGPDVELVIEAVREDLETKAEVFGKLERALPSSAVFATNTSSLSVTRIAAALQDPSRLAGLHFFNPVPLMRIVEVVPGAATRPAIPALLTELVEGCGHRAVTVADTPGFLVNHAGRGLVTEALALLEESVAGPADIDRIARDVLGLRMGPFELMDLTGLDVTAAVIDSIWQGFRCEDRLRPSYLTPNRVVAGLHGRKTGQGWYAYGDGAEGPAPEPAVNGDGDRPVFLAASGSGETAPYVESLAGALEAAGVRVERGGGPSADALVLVPVWGTTVSGAIRAGGLPAERTVGVEVLPAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNP9</accession>
    <name>A0A7K2ZNP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001504">
        <property type="protein sequence ID" value="MYW33962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6403" checksum="B40CA0A26199C2C5" modified="2021-04-07" version="1">GRPVLLHGEDGGAWPVAALAFRLGLATRIGAEDVTVLPDGRPARSNAELVAAAVRLRRSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNT9</accession>
    <name>A0A7K2ZNT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001498">
        <property type="protein sequence ID" value="MYW33929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029524705" evidence="1">
        <location>
            <begin position="24"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="155"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="50991" checksum="34CB4EFD329B0ADE" modified="2021-04-07" version="1">MIRYIRRAAALCLLLLVALLVNAARVQLFEADELDDNPANRRTTIARYDQPRGNILVGDRAVTGSKETGEQLSFERTYLHGPLYAPVTGYASQTYGTTLLENAEDGVLSGTDSLLAPLPFWNEFTRGRQPGGNVVTTIKESMQRAAYAGLSGRRGAVAALEPSTGRILALVSTPSYDPERLSGTGSAVTEAWTRLNAAKSLPMLNRAIRQTYPPGSTFKIVTAAAALDARVVKDADAATDTPSPYVLPNTRTVLPDEARGCEKASLADAIRVSCNTVMAHLGVEVGLEGMAETAGHFGFNEKGLRIPSGVARSNFDTDMSEDQLALSSIGQFNTTATPLQMAMVAAAVANGGDLRYPYLVDRVTAADGDTVQQQGSRSLDRAMSPSTAVQLQRMMVDVVENGTGSNAAIDGVTVGGKTGTAQHGVDNSGLPYAWFISWAQAPDSGRPAVAVAVVVEDAAADRGDISGGGSAAPIARAVMEAALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNZ2</accession>
    <name>A0A7K2ZNZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001540">
        <property type="protein sequence ID" value="MYW34065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076967985.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001540.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="28"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="566" mass="62137" checksum="51DC223BD1708635" modified="2021-04-07" version="1">MDADAIEEGRLRWQARYDKARKRDADFTTLSGDPVEPVYGPRPGDTYEGFERIGWPGEYPFTRGLHPTGYRGRTWTIRQFAGFGNAEQTNERYKMILAAGGGGLSVAFDMPTLMGRDSDEPRSLGEVGHCGVAIDSAADMETLFKDIPLGDVTTSMTISGPAVPVFCMYLVAAERQGVDPGVLNGTLQTDIFKEYIAQKEWLFQPEPHLRLIGDLMEHCASSIPAYKPLSVSGYHIREAGATAAQELAYTLADGFGYVELGLSRGLDVDTFASGLSFFFDAHLDFFEEIAKFRAARRIWARWMKETYGAKTDKAQWLRFHTQTAGVSLTAQQPYNNVVRTAVEALSAVLGGTNSLHTNALDETLALPSEQAAEIALRTQQVLMEETGVANVADPLGGSWYVEQLTDRIEAEAEKIFDQIRERGTRAHPDGQHPIGPMTSGILRGIEDGWFTGEIAESAFQYQRALEKGDKRVVGVNVHHGSVTGDLEILRVSHEVERDQVSQLTARKAARDDAKVSAALDAMLAAARDGSNMIAPMLDAVRAEATLGEICEALREEWGTYTEPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP15</accession>
    <name>A0A7K2ZP15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001545">
        <property type="protein sequence ID" value="MYW34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="27469" checksum="4461EA5FDE53CEE4" modified="2021-04-07" version="1" fragment="single">MSGIQGSAVSAGVDVSAATVGAGGRSMPRSLQAVLILVQLQFVATLVGAVGALSTASSVDALDGHLFGLLLYASLPGISAFVLSLYVRTGGVGVWRGLFGLQVWLVLGAVAELSGGAGAQGVARLVMPVAVVVLLARSGCRRWFRLGPGERGGRRSFSLARMVRLRRDGGQSALEYLGLVLVVVALVGAMMATGIGQQLTAEMRAAICSLTGSSCPAAGSDVIAGPGGGSGSGDEGGGAEGSGGDSGRVSGGETSSGGDSGGDSGGASGASSGGGGAGRGEGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPV2</accession>
    <name>A0A7K2ZPV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001602">
        <property type="protein sequence ID" value="MYW34365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="295" mass="31587" checksum="E44D741B45974627" modified="2021-04-07" version="1">MHSVHLAVLMTSHNRRARTLSALSALESQQGLPAHATLGVHLVDAGSTDGTPEAVRLLHPSVEVMSVGADVPRNQAMRIASRNSRSGGGGGGSHSGVPGGPSHRWTHQLWLDDGVELYPDALARLLGAADVVGAGAVVVGAVRGADGATVYSGRRGRSLELVEPGGERPEPCDTYDGRVVLLSRAAYDRVGDLDKVFRHRMGDYDHGFRARRAGVPAFVAPWPVGGCAEGPDVPGSREPGIGVREALRRVTSVTELPPRQWWVYCLRHTWPWAPFLMVSPYARTAARATVGRWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ34</accession>
    <name>A0A7K2ZQ34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001624">
        <property type="protein sequence ID" value="MYW34445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="23311" checksum="33ADD5F182D09777" modified="2021-04-07" version="1">MADAEVGPDRPDGEEEAIVLDAKGLRALAHPVRVQMVTLLRKHGPSTATRLAERLNVNSGTASYHLRQLAAAGFVAEDAERGNARERWWRSVHQLTRFDHEDLAEREPEAALAYLQSVHSAYTMRTQQGLHGLQTLPRPWREAFDMSDAALRLTPAEAREMRDEIWSVIERYKRASDDKESQDTERVWVNLHVLPEVNLAAREEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ83</accession>
    <name>A0A7K2ZQ83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_35550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001624">
        <property type="protein sequence ID" value="MYW34448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="333" mass="36477" checksum="955F6BCACEB909F3" modified="2021-04-07" version="1">MVSTAFPGAVTESVMARNALAMTDDRALCSLDPRLDYFEVQTRAGRGRGRLPVVMVKQVESLNDDYRRYLGLTSHQGSAAFIGGGPARLRSGSSLTGIGHDEERRELLAALVSEAVSRAAQTADAVLSPFLTVTDLPAYLDAAPSASVREHGVWCTLEIGEVAGIEDFLQRLPAKRRRHWNRDISEAEELGLEHDVVPFSDEVVAEAAAGIASVSQRNGMNESADLVGWRIKNYRRRPGKHFFVRTWWRGNVIAHMLCRMFDDTMDAHTLGIVDTAGLDRGTVYHFGCLLGPLRAAIDRGACRLELGIGHDSPKLRRGCTGEDTYFADLLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQB5</accession>
    <name>A0A7K2ZQB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001641">
        <property type="protein sequence ID" value="MYW34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="394" mass="42842" checksum="EA94EB66D349602F" modified="2021-04-07" version="1">MTTTDPSSLVPLHRLHFEEPGPPRLGELPGGAPAWLVSRYADVRQVLSDPRFGRSQLYAADAPALSDVPDLVNNPDLMFNQDGPDHLRLRRTLRRAFTPRAVARWQPWIAAIVEGLLDRLEGRRGPVDAVEEFTLPLPVAVISRLMGLDASAHGRLRHWSEHAFSDGSHPGEEVESVLKEFSAFGAELLAERRLDPGDDLISSLVRAADEEGGLPEAQLVSLVCGLVVGGHDSTMTMLGNALLYLLGERPESWPRIGADEEAAGRVADRLIHLVPLGDDRGTARHAAEDTEVGGVVIPAGAVVLADCGAANRDPAVFPRHTRDDLFAPLEAPTLSFGAGAHYCLGAWLARTELQIALHRLSARFPELRLAEPPDAVLWRTGTTSRSPRRLLVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQG0</accession>
    <name>A0A7K2ZQG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001650">
        <property type="protein sequence ID" value="MYW34606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029680773" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6732" checksum="CC4FEE17E4F76ADF" modified="2021-04-07" version="1">MTAHPYGRRRLSCCLFLAVLPVARFTAAPVLPEQVFWFPFWPGAVVRNGADGQGGTSHLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQL4</accession>
    <name>A0A7K2ZQL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001655">
        <property type="protein sequence ID" value="MYW34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="12013" checksum="04144706C038EC77" modified="2021-04-07" version="1">VRGEFTLEAVADRTPEGPVRDGVRRAAGTPFTTEPWRAADLLGNGQRIRADDTVPFALWTAARHPGDLEAALWATAEGFGDVDTTCAITGGVVGAATGTAGAPEEWLRRREPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQU1</accession>
    <name>A0A7K2ZQU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable subtilase-type protease inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sti</name>
        <name evidence="11" type="ORF">GT040_37085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Strong inhibitor of bacterial serine proteases such as subtilisin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001683">
        <property type="protein sequence ID" value="MYW34744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00778">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000691">
        <property type="entry name" value="Prot_inh_I16_SSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020054">
        <property type="entry name" value="Prot_inh_SSI_I16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00294">
        <property type="entry name" value="SSBTLNINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00999">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8 9" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8 9" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029982883" description="Probable subtilase-type protease inhibitor" evidence="8">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="10">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="site" description="Reactive bond" evidence="8">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="15228" checksum="887C64065CD546F2" modified="2021-04-07" version="1" precursor="true">MRHNRHAIFATIAASALVLGGLAATSAHAAPAKAESLYAPSALVLTVAQGEDPLTATVKRAVTLTCTPNAEGTHPAPEAACAELDAVGGQFTALARTSPDRMCTRQWDPVVITANGVWHGKRVTFSTTYGNACELAGSMNDSAVYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR61</accession>
    <name>A0A7K2ZR61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Roadblock/LC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001699">
        <property type="protein sequence ID" value="MYW34851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241085.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001699.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="2">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="16418" checksum="6E865D206B6C2FDE" modified="2021-04-07" version="1">MTAPSTFGLSTEARNLHWLLSNLVEEVPGVHSVTVVSSDGLMLLSSDPGHHRAKEAGPSDGPRGSSADLATIVSGIGSLTVGAAKLMDGGGVKQTMVAMDEGSVFVMSISDGSLLGVHATPDCDMSVVAYHMALFVGRAGHVLTPELRSELRTSMESAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR72</accession>
    <name>A0A7K2ZR72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001703">
        <property type="protein sequence ID" value="MYW34864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="9703" checksum="C4AD6B01DB2F02B6" modified="2021-04-07" version="1" fragment="single">MALDEARASGTHGGGCTCGDCPHGAREGHRRAVAAFLAKRDELAAGNGLPAGVAQSPSASRQWVSDELTESARTVAERGRAAGDVWLHHVWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRD3</accession>
    <name>A0A7K2ZRD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001727">
        <property type="protein sequence ID" value="MYW34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="13138" checksum="0A7D64069F927FFE" modified="2021-04-07" version="1">VLDLSRPRALAVHLVGPLGTSTQRLSPRHAELLYALAVHREGRTASELAQDLFGDATRTVTVRAEISRLRRHLAEVLAHRPYRFGDGVEVEVVHPEHPADLLPHSKAPVVTGARRGAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRD9</accession>
    <name>A0A7K2ZRD9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">argF</name>
        <name evidence="10" type="ORF">GT040_37910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="WWKE01001723">
        <property type="protein sequence ID" value="MYW34903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="156"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="334" mass="36127" checksum="820983A5B47363C6" modified="2021-04-07" version="1">MAIDLTGRTFLKELDFTAEEILALVALAGELKAAKKAGAEVRRLRGKNIALIFEKTSTRTRCAFEVAAADQGASTTYLDPSGSQMGHKESVKDTARVLGRMFDGIEYRGDSQQVVEELAAYGGVPVFNGLTDDWHPTQMLADVLTMTEHSDKPVTELTFAYLGDARFNMGNSYLITGALLGLDIRIVAPEMYWPAPSVVEQAEKLAAVSGAKVTLTADIAEGVRGADFVATDVWVSMGEPKEVWDERIAALAPYAVTMDVLRATGNPDVKFLHCLPAFHDLGTQVGRDVHAAHGLTELEVTDEVFESAHSVVFDQAENRMHTIKAVLVATLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRT9</accession>
    <name>A0A7K2ZRT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_38810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001770">
        <property type="protein sequence ID" value="MYW35075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076967794.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001770.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW35075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="357" mass="37743" checksum="20330968B70F02E7" modified="2021-04-07" version="1">MARATTVISVTAVIATEALSKRFPRVTALDRLTLDIGPGVTGLVGSNGAGKSTLIKILLGLSPATEGRAAVLGLDVATSGAAIRERVGYMPEHDCLPPDVSATEFVVHMARMSGLPPTAARERTADTLRHVGLYEERYRPIGGYSTGMKQRVKLAQALVHDPQLVLLDEPTNGLDPVGRDEMLGLIRRIHTDFGISVLVTSHLLGELERTCDHVVVIDGGALLRSSSTSDFTQITTTLAVEVTDSDTHPDGTDALRQVLTKAGVALVGQDGLDAEGLPGAGHILLVEATGEETYDLVRDSVAGLGLGLVRMEQRRHHIAEVFRTEQGAAHTVPAPAAGAVQQAATPGPYQKEGERSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRW8</accession>
    <name>A0A7K2ZRW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001771">
        <property type="protein sequence ID" value="MYW35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="336" mass="37914" checksum="82ED3ACCDB98D1BB" modified="2021-04-07" version="1">MELDAGGRAVRLSNPDKVYFPAKGYTKRDVAEYFLAVGPGITRALNHRPTTLQRFVDGVEGDFFYQKRAPKNLPEWIPTARIAFPSGRPADELCPTELAAVIWAANLGTLTFHPWPVRAGDTDHPDELRIDLDPQPGTDYADAVTAAHELRSVLEDHGVRGWPKTSGGRGMHVFVPIEPAWTFTEVRRAAIAAGRELERRMPERVTTAWWKEERGERIFVDFNQTARDRTIASAYSVRPFPHAPVSAPLRWEEIDDAEPRDFDIRTLPVRYAEVGDVHADMDQEAFRLDGLLELADRDEKERGLGDMPYPPEYPKMPGEPKRVQPSRARHDDGDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS85</accession>
    <name>A0A7K2ZS85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001782">
        <property type="protein sequence ID" value="MYW35167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="17342" checksum="B0BB045F853505A0" modified="2021-04-07" version="1">MARRLRTVGLEFTESAPIRLVFAAEVSAPPDVVYRALAEDVASWPSWFTAVTRATPTDGGAGREVRLRGGVRFRETIVAAEPGERYAYRVDETNAPGLRALVEEWRLTADGTGTRVQWTFATDGTGPFRSVLGVARLGMGRSFRDAVRRLDGRLTASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSB1</accession>
    <name>A0A7K2ZSB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase family 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_38995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001774">
        <property type="protein sequence ID" value="MYW35109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029577891" evidence="5">
        <location>
            <begin position="29"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="6">
        <location>
            <begin position="31"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="418" mass="46101" checksum="9CEA789FD4AD1B9A" modified="2021-04-07" version="1">MPAKRRLITTCIAAAVLSLLAGGGIAGQLPPGTDSVDSAAPGPQGSRGAGSTAHGAYLDYGPAGVSRMADLSRWLGGAELRVGHTYLPGDLWVNIEGTPDFLDAWADWRKADEDRMFVLNVPMLERNEERVPDAQVRRLLRSGAAGDYDQHFTRLAERLVSLGVPDTVIVLGWEMNGTTYTHRCGPDPASWKAYWQRIVTAMRAVPGQEFRFDFTPSRGLDAVPWTACYPGDDVVDIIGMDSYDQPPGESFDDQINDPYGLQKHVDFAAERGKPISFPEWGLFRNGDNPEYMRRMLDWIDRHQPLYQTITDYCPHGVWQCKSNPRSSRVFRTKLAEMAAPVKPAPPTTAPSPTPSPTPPPTPTPTPTVPPAVQPSPTPSVQPTPTTPEAPADRRWCVTVPFGDLLGPWLKERRICFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z613</accession>
    <name>A0A7K2Z613_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000012">
        <property type="protein sequence ID" value="MYW27776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046200">
        <property type="entry name" value="DUF6233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19746">
        <property type="entry name" value="DUF6233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6473" checksum="CC07E702774FB910" modified="2021-04-07" version="1">RGPGRAVLHAVDCEEAPQGAPLLPLERALDVAEQPGTRLCSLCGAAQELDPVLRGFDHIEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z653</accession>
    <name>A0A7K2Z653_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000019">
        <property type="protein sequence ID" value="MYW27819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="54"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="293" mass="30318" checksum="FD6938C71404DA51" modified="2021-04-07" version="1">MSDSAARDRDDAETESALAHPVVAPDRTAAYGDHPDQVIDFYAPRDGRTAAPLVVLLHGGAWRAPYDRAHVSPLADFLARRGFAVASVEYRRGGEEGHGQEPGADPVAGRWPETLDDVAAALDAVPALAARELPEADVRRIVVTGHSAGGHLALWAAARHVLPEGSPWHLPAPPPLRGVVALAPIADFATAVELGVCGGAVTQLLGEGGESADRTAQTDPTALLPTGIATAIVHGEEDIVVPLAVSEAYVDAAAKSGEMVGLTLLGDVGHFPLIDPAADACAIVAEEITQLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6B0</accession>
    <name>A0A7K2Z6B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2071 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000042">
        <property type="protein sequence ID" value="MYW27874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="25521" checksum="D05B9AF84EB3605D" modified="2021-04-07" version="1">MPPLLTQSWLDLAFLHWAADPADVAPLLPAGTVPDTFDGVTYVGLVAFRMHRVGWLGLPGIPYLGTFPETNVRLYSVDERGRRGVVFRSLDASRLIPVAVARTVFRLPYVWARMGIERSGDTLTYTSTRRWPGPRGARSRIVLRAGDPIGEPTPLEHFLTARWALHSSFFGRTAYLPNAHPRWPLHRAELLEYDEDLVAAGGLPAPVGEPVSVLYSPGVPVRFGPQRRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6M0</accession>
    <name>A0A7K2Z6M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_01545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000066">
        <property type="protein sequence ID" value="MYW27989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="527" mass="56734" checksum="20BBD1FCA27F2078" modified="2021-04-07" version="1">ARPGETPAVFGALAPAASRASVREDGDGPGSLVERLGSLPEGRRQEAVASFVRGQVALVLGHADPETVDVDRLFSELGFDSLVSVELRNRLNAATGLRLSPSVVFEHATPALLTKHLHSELFAGERDDASQGRTTVDFAAEVHLPEDVRPADEVVRVADDPREVLLTGATGFLGAFLLRDLMRSTTARVHCLVRGEDRADAERRLRDSLAWYRVADEIDEDRISVVVGDLTAPGLGLGEDVFDDLARRVDVVHHAGATVSWLRPYTELRQANVAGLREVLRLAARHRTVPVHYVSTTGVFPAPEPGTRPVPAKPGDPTGPAASLWNGYLQSKWVAEQVIEVARDRGMPVSVYRVDVVCGDRHSGACQTRDFVWLSLKGLLQAGAVPDRLAGAFHMVPVDYVSGTITTLAADPAAANGTYHLYNEQTQPFAEFVGHLRAAGYELPEVSWDAWRELVRSDPGNALTPLLHAFDGAMAGDGSETYPPMDVSATEAALKGSGVSCPPVDRELFAKYVDFFVDAGYFPASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z716</accession>
    <name>A0A7K2Z716_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">lexA</name>
        <name evidence="17" type="ORF">GT040_02145</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="WWKE01000100">
        <property type="protein sequence ID" value="MYW28103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026242273.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000100.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="16">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="15">
        <location>
            <begin position="147"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW28103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="28759" checksum="42DB9E1DFE778D47" modified="2021-04-07" version="1">MTTTADSATITARDHRSQSRLEPVHAMNDSVTNTDGPEPARPGRSLPGRPPGIRADSSGLTDRQRRVIEVIRDSVQRRGYPPSMREIGQAVGLSSTSSVAHQLMALERKGFLRRDPHRPRAYEVRGSDQPSTQPTDTTGKPAASYVPLVGRIAAGGPILAEESVEDVFPLPRQLVGDGELFVLKVVGDSMIEAAICDGDWVTVRRQPVAENGDIVAAMLDGEATVKRFRREDGHVWLLPHNAAYQPIPGDEATILGKVVAVLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Q4</accession>
    <name>A0A7K2Z7Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_03555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000149">
        <property type="protein sequence ID" value="MYW28371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="351" mass="37213" checksum="7A45BE2ADC7CB33E" modified="2021-04-07" version="1">VDPVTYKANPTAMAAAITPRTALVVASAPSYAHGVIDPVERIAEAAAGHEVLCHVDACIGGWLLPYLRRAGRTVEPFDFSLPGVTSLSVDLHKYGYADKGASVVLYRNAELRRHQYFAHAGWPGYPVVNPTVQGTKSAGLLAQAWAVLQHIGEDGYTTLAARVAEASDHLIEGLRATPDVHILGEPEAGLVAFTVLTSATPDRLSGTPDLSLLLHLADEMRVRGWYLQPQLSFDGLPPNLHLTLTPATVDRVDALLTDLTAALTTARALPPITPDPALTELAATLDPDTLTPEDVAGILAFAGLGEGPDGSGGPGGLPERMAPVLFLLDTLPARLKERLLTEFVGSVFRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Y4</accession>
    <name>A0A7K2Z7Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000173">
        <property type="protein sequence ID" value="MYW28456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="5822" checksum="5D45A7A8C6DB4EF1" modified="2021-04-07" version="1" fragment="single">MRARQRDDDLLRMQRLARNGGTAGLLRWLAGRADGWAGIAGSDGTLLSASGAPPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z825</accession>
    <name>A0A7K2Z825_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000194">
        <property type="protein sequence ID" value="MYW28491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16306" checksum="7F85399B5674661A" modified="2021-04-07" version="1">MDWTLEVIVLPVTDLDRARDFYRDKIGFHVDIDGEVMPGARVVQLTPPGSGCSIALTDGIPNPTGDPQPGTYHGLQLCVTDIDAAHAELVARGVEVSEPQRYAPEDGATFMYFTDPDGNGWAVQEYRRRLTEPLHQVLAGLAAKGTAGTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8D0</accession>
    <name>A0A7K2Z8D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000212">
        <property type="protein sequence ID" value="MYW28609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="14037" checksum="C3F5AA321141E99C" modified="2021-04-07" version="1">MGQRYYVDPQRIESETRQLEEIGKLARSMTEEFLDDLAPTISWPGTNSEFSEKARPQEQKERQITKDTVMAVQDAVMAITDATLSNVRMMQETRDRNIEEIDRNNNRLDADGLGGPGRYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8E0</accession>
    <name>A0A7K2Z8E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000214">
        <property type="protein sequence ID" value="MYW28620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="44" mass="4751" checksum="F0BAE0BAF4D55CCD" modified="2021-04-07" version="1" fragment="single">MILTVTPNPSLDRTYELPDLVRGTVLRATADRVDPGGKGVNVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8K1</accession>
    <name>A0A7K2Z8K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000245">
        <property type="protein sequence ID" value="MYW28684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7370" checksum="511E8EFF11AC74D5" modified="2021-04-07" version="1" fragment="single">MLSVEEPIGVTEAAQVPQQRGEHLLDAAVRYAEERHWDVFPGTWLEAVEGRERCSCGAAACPLPGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8N9</accession>
    <name>A0A7K2Z8N9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">ruvC</name>
        <name evidence="16" type="ORF">GT040_05275</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="WWKE01000246">
        <property type="protein sequence ID" value="MYW28693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW28693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="22035" checksum="A727144812E1CE59" modified="2021-04-07" version="1">MRVLGVDPGLTRCGVGVVEGVAGRPLTMIGVGVVRTPADAELGDRLVAIEQGIEQWLDEHSPGYVAVERVFAQHNVRTVMGTAQASAVAMLCAARRGIPVALHTPSEVKAAVTGSGRAEKAQVGAMVTRLLRLDAPPKPADAADALALAICHIWRAPAQNRLQQAVAAHRISAAPHTLGASRTQPTPGISRTPGASRTPAASRTPRTLKGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8R4</accession>
    <name>A0A7K2Z8R4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable M18 family aminopeptidase 2</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">apeB</name>
        <name evidence="12" type="ORF">GT040_05470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000249">
        <property type="protein sequence ID" value="MYW28731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00467">
        <property type="entry name" value="Aminopeptidase_M18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022984">
        <property type="entry name" value="M18_aminopeptidase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW28731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="434" mass="45689" checksum="603FD4C123968EF5" modified="2021-04-07" version="1">MTPAPHRSHTDDLLAFIAASPSPYHVVASAAQRLEKAGFRELLGTDDWTGATGGCFVSRAGALIAWYVPEGAPAHTPFRIVGTHSDSPNLRIKPAPDTGSSGWRQIGVEIYGGVPLNTWLDRDLGISGRLALRGGPDGTPRSSLVQIDEPLLRVPQLAIHLDRTVNDGVALDRQRHIAPIWALGDPREGELLRLVAAAAGEDPADVLGWDLMLHDIQPPGYLGAEREFVVASRLDNQVSVHAGVTALVDAATGVTEPSFVPVLAAFDHEEVGSGSETGAQSPLLERVLSRSVAARGGSDEDWSRALAGAFCVSADMAHAVHPNYAERHDPDHRPLPNCGPTVKVNVNQRYATDSTGIAMFTAACERAGAPWQPFVANNAMPCGTSIGPLTAARLGVTTVDVGVPGLSMHSARELCGVKDPAYLAAILGAVMTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Y6</accession>
    <name>A0A7K2Z8Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000254">
        <property type="protein sequence ID" value="MYW28793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045691">
        <property type="entry name" value="DUF6056"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19528">
        <property type="entry name" value="DUF6056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="508" mass="54741" checksum="8EEB4CC3BBB37449" modified="2021-04-07" version="1">MTDGARETAVSDDPAGRERAPQRERAPERRPEPGHAPRTALWVSALALPPLALLAAASWFGRWVRPSADDWCFLPAVRDDGITGLVGKFYFDDNGRVANAMLVGAYAKFQVAGHQWFPAVSGILILAVLWAVTVLALRRGGITVPRGLPLLVAAMVTALFLFVTPNTYKTFYWPAASVSHTLPPVLACAALIPLLLARTRRGRGFALAVALLAGAFIATLSEETAVVMVLVLLATLLLSGRLIQPPNRAFALRWCVAGLAGTSAGGLVLITSPGSIRRRERFGAETKSLLAPDSLAASLRHFAEITVQTVTTWQYVGAVAVGVLLGLLGDRRDGRTPRPPAHWPLLAWTGLLTLLLAGYLCTVIAYPVFRDRVSDPSANRLWNDYLLLYVVLLTAAGALLGLAVRQHVRRTAPAKAMCAALCVLVCAGPAVSLLDLDTTMRARAEKWDAQDRRLREGAADGERVMPYERLVVSAMLEPFGRGGANYWPGGCVADFYGLERVTDGARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Z0</accession>
    <name>A0A7K2Z8Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000254">
        <property type="protein sequence ID" value="MYW28792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="246" mass="26267" checksum="AB35010AED4BB515" modified="2021-04-07" version="1">MPIRTSTPHIPTEDGRADAFAAFPDTGGRHPGVLMYPDAFGIRPVLREMAAELAGHGYYVLVPNVFHRHGPTPVTDLPAYIGGEERSAVLDRLMPLIREHTAERTLRDADAFLRFLTTRPEVAAGPVAVTGYCFGGLLAVRTAAAHPDQVAALAAFHAPVGADGPDALAGITARAHFGHAASDLTPEALRELNKTLDAAGVDHTSEIYPGTVHGFTMSDTDAFDPAGLKLHWDRLLPLLGRTWEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z955</accession>
    <name>A0A7K2Z955_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000266">
        <property type="protein sequence ID" value="MYW28852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8183" checksum="596A60398F903539" modified="2021-04-07" version="1">VLVVHDPTTAVDAATEARIATGIRRARTGRTTVLVTSSPALLAATDRVVLIDGGTIAAEAPHEDLVRDHPVYRTAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z959</accession>
    <name>A0A7K2Z959_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000284">
        <property type="protein sequence ID" value="MYW28884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="20236" checksum="21137C73E5EAFCA2" modified="2021-04-07" version="1" fragment="single">PNATPQEASGLLRTAAAYGWLAGDADAVRTAAARLATDAGAADPLVEGLERLCEDDAEHGLPLLTRFLESRPGPSGPRDADEEQAVRMLALTCGLLLGDDEAAHALASADVRRCRSQALIGQLPYTLDVLAQTQLLAGHHRDAEAAVTEAEEIARDTGMRRRLVRLGAVRARMGAIEGDARRVRELADATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9B1</accession>
    <name>A0A7K2Z9B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000299">
        <property type="protein sequence ID" value="MYW28941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_C" evidence="1">
        <location>
            <begin position="266"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="404" mass="41924" checksum="A08BB7C0CE885780" modified="2021-04-07" version="1">MPASSSSSSSSSSSLSPRLPRKVAVVGISLADCGRVDDATPYALHAQAARRALADSGLDRSVVDGFASAGLGTLAPVEVAEYLGLRPTWVDSTAVGGATWEVMAAHAADAIAAGRAKAVLLVYGSTARADIKAGRRTSNLSFGARGPLQFEVPYGHSLIAKYAMAARRHMHAYGTTLEQLAEVAVTARANAAANPEAMFRDPITVDEVLSGPMIADPFTKLHCCIRSDGGCAVLLAAEEYVPDTAKAPVWILGTGESASHSTMSEWEDFTVSPAAVSGRLAFERAGVRPSDIDLAEIYDAFTYMTLVTLEDLGFCAKGEGGAFVEKGRTGLRGELPVNTDGGGLSACHPGMRGLFLLVEAVRQLRGEAGARQVHKAGGRLPELAVASGTGGWFCSSGTVVLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9E9</accession>
    <name>A0A7K2Z9E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000302">
        <property type="protein sequence ID" value="MYW28966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="291" mass="31595" checksum="21B2F9C75DBF6443" modified="2021-04-07" version="1">MTGSDGEQALAILGPQATALVKELDRIFTGWGLADGAEEISAPPLFPVTDLEKFDVYTNFPHLAWVAGSLELADDQFRPVEGKFGPGAVTEARYGLPHATCYGAYLFHEGGQVADDSLVTLVNRCFRNEDHYSGLRRLASFQMREIVALGSFDHTQEVLARFTGRIQAFAAALGIELGREAAGDPFFQNDSGRALMQKLSPVKYEFQYGDLAIASVNTHRNFFGERCSIRLDSGEHAYTSCVAFGLERWLAVLTEHFDADLDAALDAVQAAAPDAVRGAAPTDVRTAAETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9F2</accession>
    <name>A0A7K2Z9F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2'-5' RNA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000301">
        <property type="protein sequence ID" value="MYW28958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="19531" checksum="AC390D59F1413BAE" modified="2021-04-07" version="1">MHSIELLPDEATERVVRRVWRSIADEGLPSQAGHRHPTNRPHLTLATADALPPPTRGALAEALDALPLPLHLTGVLRFSGRSNVLAWAVRPDAALLALHERVWRILREADGDGRSHPLLAPGRWVPHITLGRGRGAIWPGPDSRWLPPGAAAVPGRWAEARTYDSTSRTTDRIGPDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9L2</accession>
    <name>A0A7K2Z9L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar porter family MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_07045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000315">
        <property type="protein sequence ID" value="MYW29037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="26"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="472" mass="50585" checksum="38247D3D38D441B5" modified="2021-04-07" version="1">MTSAATGPESGARAAHPDHLGHVIFITAAAAMGGFLFGYDSSVINGAVEAIRDRYDIGSGTLAQVIAIALIGCAIGAATAGRIADRIGRIRCMQIASVLFTASAIGSALPFALWDLAMWRIIGGFAIGMASVIGPAYIAEVSPPAYRGRLGSFQQAAIVIGIAISQLVNYAVLQIADGDQRGKILGLEAWQWMLGVMVVPAILYGLLSFAIPESPRFLISVGKKAEARKILEEVEGDKIDLDARVTEIETAMHREHKSSFKDLLGNRFFFLPIVWVGIGLSMFQQLVGINVAFYYSATLWQSVGIDPTDSFFYSFTTSIINIIGTVIAMVLVDRVGRRPLALVGSVGMAIALAVEAWAFSADLVDGKLPTTQGVVALVAAHVFVLFFALSWGVVVWVFLGEMFPNRLRAAALGVAVFAQWMANWAITASFPSLADWNLSGTYIIYACFAVLSIPFVLKFVKETKGKTLEEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9N2</accession>
    <name>A0A7K2Z9N2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_07275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000328">
        <property type="protein sequence ID" value="MYW29081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW29081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="461" mass="50328" checksum="504D7AB9797CC9A3" modified="2021-04-07" version="1">MTPGPRTPPLDLLGVGAGPFNLSLAALADGVPGLRSAFHEQRTAFHWHPGLLIEGATLQVPFLADLVSLVDPISPWCYLNYLKTRRRLFPFYFAERFHIHRSEFDNYLRWVSTELPSTHFGHRVDAIAWDAGESAFAVDFTRLGPDGESLGSGLTHARNLALGVGTAPHVPEPLRALEADPVPLVLHSADYLAQRDRLLAARHVTVVGSGQSGAEVLLDLMRLRPEGAEGLTWLARTPAFAPMEYSKIGLEQFTPDYTRYFHGLPQATRDRLLPSQWQLYKGVSGDTLGDIHDELYRRSLGGGWPDVTLTPGIEVTGATVTGSGRIELAVEHGQQEARGRLATDAVVLATGYRERPVDTLLAALDPYIVRDDAGRPQVDEAQRLVLETEIDGSVFVQNAERHTHGVGAPDLGLAAWRSAVIINALTGKETYPLPDRTAFTTFGLGADDRGGVPIRIAGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9R8</accession>
    <name>A0A7K2Z9R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000337">
        <property type="protein sequence ID" value="MYW29100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="21240" checksum="099A406DD6BF418E" modified="2021-04-07" version="1" fragment="single">MASTASSPLPAPHTAPLTVGFDLDMTLIDSRAGIAATYRALSTETGVPIDEELVVSRIGPPLEEELAHWFPAGQVAAAGDRYRALYPDHAIAPSTALPGARESIAEVRALGGRAIVVTAKYEPNAKLHLAHLGIEPDSVIGWLWAEAKGEALREHGAQVYVGDHVGDVRGARAAGALSVAVTTGPCDERELRAAGADVVLADLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAJ9</accession>
    <name>A0A7K2ZAJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="36" mass="3463" checksum="5F806E06F96B370E" modified="2021-04-07" version="1">GSSDATTQLALASGAAVALGAGAMFLVRRRKTGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAM2</accession>
    <name>A0A7K2ZAM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SPFH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000406">
        <property type="protein sequence ID" value="MYW29378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6269" checksum="CA0C10ADC312B709" modified="2021-04-07" version="1">RAEAQAAWLRVHGEVDPATLHALAATRLAENVPRIESLTLSPDVLTGLLAKLGRADGGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAZ0</accession>
    <name>A0A7K2ZAZ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">coaD</name>
        <name evidence="8" type="ORF">GT040_09190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000418">
        <property type="protein sequence ID" value="MYW29445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="18628" checksum="E52ADB64EBDBC56E" modified="2021-04-07" version="1">MTGPESEGITVRRAVCPGSFDPITNGHLDIIQRASRLYDVVHVAVMINQSKKGLFTVDERIELIREVTAGFGNVEVESFHGLLVDFCKQREIPAIVKGLRAVSDFDYELQMAQMNNGLSGVETLFVPTNPTYSFLSSSLVKEVATWGGDVSHLLPPTVHEALTKRLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBX6</accession>
    <name>A0A7K2ZBX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000512">
        <property type="protein sequence ID" value="MYW29857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="81" mass="8182" checksum="027977BA16179A43" modified="2021-04-07" version="1" fragment="single">MSATRAADAADDFRGPLDIARAATVVLDGRDTVVGWSPAATELLGFGAHEAVGRPLSAFLSPLPAEGPLPAASDRPAGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC90</accession>
    <name>A0A7K2ZC90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000522">
        <property type="protein sequence ID" value="MYW29885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="82" mass="8531" checksum="203AD0BF6223ED43" modified="2021-04-07" version="1" fragment="single">MLAETICSAASAAGLGIAAVTAYRKRFLTATRIAAYSLVPIGLVLTGVVAWVSGIAFKPSVWIGFGVLGLAWALFMTTRAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC99</accession>
    <name>A0A7K2ZC99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000554">
        <property type="protein sequence ID" value="MYW30001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512718.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000554.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="183" mass="19808" checksum="5F45C7A1E2E9DB91" modified="2021-04-07" version="1">MPLPFLTADRAFDASAEDVALPFDDHDSWRRPYRPGPWRVAAAAGQLLLASFVLLAAMIIAFAGAPSGALVCLLLAGALIGAALRLLRVGAWVSRHGVRRVGFFRTTTVPWGATASVRTVQQPVKWLGLPRTVQGQALIVVRQNGETLPPLASDHNADFLGREEAFERATDAVEAWADEYRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCA6</accession>
    <name>A0A7K2ZCA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000552">
        <property type="protein sequence ID" value="MYW29986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="23278" checksum="9E592BFC0AB2D265" modified="2021-04-07" version="1">LRALAGLDTPALALHVAGLVREYIDAHPEDGTHAAEYVDLRLEHGPAARALLLPLVTGLLRDRPAPPPVRSALARVLAGAGSTASRPLRAELLEVLLEFEQTTGRDPDVLDALLQAAAAGAGARPEIRTRALVHRAGMLLVRTPEGAARFDRRLVELARDVPGFAALVIRWLADAPQEWAAVVGPSARRTVEALETSRRAMPMPMQAAGREHGSLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD32</accession>
    <name>A0A7K2ZD32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000630">
        <property type="protein sequence ID" value="MYW30270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="167" mass="17961" checksum="2DB79AD21336AAD9" modified="2021-04-07" version="1" fragment="single">MNPDRRDRLRDAAIAVLAEEGGRGLTHRAVDRTAEVPDGTTKNYFPTRDAVLRAVAERCLEQYLALTTRLTAEPGPADREGLTALFRTLLENVTGPGRTRLLAYLELQAEAARRPWLSALLDPMASGDFAGFEAAQRSAGLPVTPRRAATVTLALHAAIPHLLGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD89</accession>
    <name>A0A7K2ZD89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000654">
        <property type="protein sequence ID" value="MYW30327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13055" checksum="F5B050A787DDA612" modified="2021-04-07" version="1">MGETAVDAAETGQTSRTDARKAARAERRAAKLAREIGSFAKEHGGAEGQLAYIGQAGARIVLVGQDGAWGDLVAPTYAVAESAAEKSGITMHEEFDGDFALKVRTGPYEWSRMAGIQVGGPSNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDN1</accession>
    <name>A0A7K2ZDN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000679">
        <property type="protein sequence ID" value="MYW30470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="22111" checksum="C6DCF1D0C36707C3" modified="2021-04-07" version="1">ISSYNWDEPCGQFYLLDRGPEGVAPPPPPQDRRGWARSYGGVDAGNMLLQLTVQGTSREAVVLKGLYVRVVSRKAPLPWSAYLMGNGCGSSIVPQTFASDLDTGHPIMTPVPGTRGDRTIPAEPFPYKVSSEDVEVFNLDMKAGGYDVSWYLELKWSSGGREGMLRIDDHGKPFRTSGMRGRPMYTYGNDEVKWEPYQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDN8</accession>
    <name>A0A7K2ZDN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF417 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_14435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000671">
        <property type="protein sequence ID" value="MYW30446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="17951" checksum="C5A7807003ED85B1" modified="2021-04-07" version="1">MNGYSGGSYGLSEPKGLRERAGQYALLPLRLFLGVTFVYAGLDKLTDSGFLSATGSGSIGELMNTVRDSSAVPALVDLALKSPEGFGYAIAIGELLVGLGTLVGLWARLAALGGALISLSLWLTVSWQSTPYYYGNDLPYLMAWLPLVLAGASMFSLDAFLASRRRRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDW0</accession>
    <name>A0A7K2ZDW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000714">
        <property type="protein sequence ID" value="MYW30543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="6743" checksum="89F0BBDA5AB73FC0" modified="2021-04-07" version="1">MGPVFPIDREPEERALGDEAGDGETGRQATGRRAARLRPGTMPGAGQLSPAALVEAAPDSGIRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEK0</accession>
    <name>A0A7K2ZEK0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">argB</name>
        <name evidence="9" type="ORF">GT040_16000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000756">
        <property type="protein sequence ID" value="MYW30739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030570382.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000756.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="33154" checksum="6C4184B490484BA5" modified="2021-04-07" version="1">MSAARKHTALPKAQILIEALPWLTRHNGKTVVIKFGGNAMIDEELKAAFAQDVVFLRHAGLKPVVVHGGGPQISAQLDKQGLVSEFKAGLRVTTPEAMDVVRMVLAGQVQRELVGLLNQHGPLAVGMTGEDAHTITATQHRPTIDGESVDIGRVGEITAIDTGAIQALLDDGRIPVVSSIARSADDHHVYNVNADTAAAALAAALNAETLMVLTDVEGLYEDWPNSDDVISRLTASQLEKLLPELSSGMVPKMQGCLHAVRNGVETARVIDGRVQHSILLEIFTDEGIGTMVVPDAPIDVHAAHGDQQQGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEK6</accession>
    <name>A0A7K2ZEK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000758">
        <property type="protein sequence ID" value="MYW30766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029609100" evidence="2">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="13301" checksum="C2F0934311F14432" modified="2021-04-07" version="1">MMYGQFLLLAALLFGIVTMHTVGHPAAEHAPSAAVPVSVSVADAVAMPVATASDAAHSSPDHSPMSGMDPLSVCLAVLGAWGLALVGAWLLLGLRADGRALGTPVGAGLLRVLRPNPPPPISVLASVSVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEL2</accession>
    <name>A0A7K2ZEL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000763">
        <property type="protein sequence ID" value="MYW30807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="187" mass="19699" checksum="4F88B1B67C22F989" modified="2021-04-07" version="1">MPDDVGGRPFPDGWEPDDNRGGADKDFASVVFDEDFVRAAVVHEPTAVERLLAAAEARAQADAARARRSRRPTDGEYGSYGRSRAPHDPQDLDYDPDGDDDAGPGSYGPGGYRGAARWHRPVAWLLALVMGVGMVALAFSAVYRGASANRQDPVPPPVTSGVDQPGAIPPAAVEHSRPTVSATPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEV9</accession>
    <name>A0A7K2ZEV9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_16810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 11"/>
    <dbReference type="EMBL" id="WWKE01000779">
        <property type="protein sequence ID" value="MYW30890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="12">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW30890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="415" mass="42956" checksum="A6C252101BDFB9A3" modified="2021-04-07" version="1" fragment="single">MTGIRLTAPAPGWAIDADVVVVGSGVAGLTTALRCAAAGLDTVVVTKARLDDGSTRWAQGGIAAALGEGDTPEQHLDDTLVAGAGLCDEEAVRTLVTEGPDAVRRLITTGATFDTTDSGDIALTREGGHHRRRIAHAGGDATGAEISRALVEAVRSAALHTIENALVLDLLTDAEGRTAGVSLHVMGEGQHDGVGAVRAPSVVLATGGMGQVFSATTNPSVSTGDGVALALRAGAEVSDLEFVQFHPTVLFLGADSEGQQPLVSEAVRGEGAHLVDATGTRFMLGQHELAELAPRDIVAKAITRQMHEHGTEHMYLDARHFGARMWEQRFPTILAACRAHGIDPVTEPIPVAPAAHYASGGIRTDLRGRTTVPGLYACGEVACTGVHGANRLASNSLLEGLVFAERIAADIAETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF13</accession>
    <name>A0A7K2ZF13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000805">
        <property type="protein sequence ID" value="MYW30951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="269" mass="28748" checksum="33152F05185524DD" modified="2021-04-07" version="1">MRTARGDFAVLDAAPANAPARATALLLPGYTGSKEDFIALLEPLCTAGYRVVAVDGRGQYESEGTDRQETYAQRELARDVLAQAAALTGGEGTLHLLGHSLGGQIARAAVLLDATPFRSLTLMSSGPAEVVAAQRDKVKMLSDALSVLTMDEVWEAMRALDPPQDADTGDGEDMRRRWLRHHPAQLIATGAQLSAEPDRVDELAALGLPVHVLSGERDDVWPVERFDAMARRLGAHRTTIAGAEHSPNTARPHETAEALAAFWDGVDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF75</accession>
    <name>A0A7K2ZF75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system NifU family Fe-S cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000814">
        <property type="protein sequence ID" value="MYW31003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="12728" checksum="92F2CE297E03E92E" modified="2021-04-07" version="1">VNPTCGDEITLRVKYDGETIADVSYEGQGCSISQASASVLNELLVGKELAEAQKIQAAFLELMQSKGQLEPDDAMEEILEDAVAFAGVSKYPARVKCALLSWMAWKDATAKALSEGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFF6</accession>
    <name>A0A7K2ZFF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2277 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000834">
        <property type="protein sequence ID" value="MYW31072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8630" checksum="E90ABAF041C5CC25" modified="2021-04-07" version="1">MCRSIKTLRPPALPEEATEEDMRAAALQYVRKVSGFRAPAAHNREVFDRAVDEITEATMRLLDGLEIRGSAARSTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG07</accession>
    <name>A0A7K2ZG07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_19000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000882">
        <property type="protein sequence ID" value="MYW31301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966501.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6212353"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11825" checksum="54326C06B89E1B88" modified="2021-04-07" version="1">MTYVIAQPCVDVKDKACIEECPVDCIYEGQRSLYIHPDECVDCGACEPVCPVEAIFYEDDTPEEWKDYYKANVEFFDDLGSPGGASKLGLIERDHAFVAGLPPQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG15</accession>
    <name>A0A7K2ZG15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000876">
        <property type="protein sequence ID" value="MYW31282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="8408" checksum="6919B60C95E53328" modified="2021-04-07" version="1">AYGPREAQPVTGHLTTAQAAQAAQAMPAAPAAPAAQHPQEVFERAAAHGDDHTIKFADTALDVGDAAALVAAGRAIELNTPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG34</accession>
    <name>A0A7K2ZG34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-phospho-L-lactate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000870">
        <property type="protein sequence ID" value="MYW31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="13667" checksum="6B9E41A8D4AF076D" modified="2021-04-07" version="1">AAGLNAALAYGARSVRALAPAVPVAALNADLPALRAGELARVLDFASAFPRAFLRDAAGIGTTFLSCAGGTELRPVFGGPSAARHLASGAVEITLPGVDSVRRDVDTGEDLEVALTIGAGPYTQRLTAALASAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG51</accession>
    <name>A0A7K2ZG51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000899">
        <property type="protein sequence ID" value="MYW31337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="8042" checksum="5E0434C56005BFC9" modified="2021-04-07" version="1">MTGPPAHSDHPEQPPIEAVLHEAGFPVDLLTEEQRVVLSELTPQELTLLLDVKNRLDAVGPEVQAHGEIAGGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG96</accession>
    <name>A0A7K2ZG96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_19460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000910">
        <property type="protein sequence ID" value="MYW31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="360" mass="36996" checksum="14C0F666753DB3E4" modified="2021-04-07" version="1">MTKEDPGAAAGPKAAPKSPRSRAFVLTVGLSLALLAGCLLSAAIGAYSIPIGDVLGSLQHRIGLGGQPLDRVGESVLWNVRLPRVVLALLVGASLGCAGALMQGVFGNPLAEPGVIGISAGAAVGAVASIALGLTFFGNWTITVFAFIAGLATVLLVYTLSRSGGRTEVVTLILTGIAVNAFAGALIGLFIFFADNAQITQITFWQLGSLSQATWPKVLAVLPCALAGLLIAPFYARKLDLLALGERPARHLGVDVERLRITLVLVVALLTAAAVAVAGIISFVGLLVPHLLRMANGPGHRFLVPGSALGGALVLVAGDLAARTVAAPAELPLGVLTALFGSPFFFWLLRRTRRKQGGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGQ7</accession>
    <name>A0A7K2ZGQ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein GT040_20015</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000933">
        <property type="protein sequence ID" value="MYW31498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="16283" checksum="D02A63DB02493053" modified="2021-04-07" version="1">MALDQSFVGRTYPPTPAYEVGRQKIREFAEAVGDTHPAYVDVEAARALGHPDVIAPPTFVFSITYRAAGEVVQDPQLGLDYSRVVHGDQKFSYVRPVRAGDRLTVTSTIETIKSMAGNDIVDIRGEVHDEAGELVVTALTKLVARAAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGW3</accession>
    <name>A0A7K2ZGW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folK</name>
        <name evidence="9" type="ORF">GT040_20450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000967">
        <property type="protein sequence ID" value="MYW31582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21735" checksum="DE2562ED8BA9F856" modified="2021-04-07" version="1">MTAFSTEGQSDPTVQPVPTAVVKQVDAADITLSNPKMAVIALGSNLGNRLETLQGAVDALEDTPGLRVKAVSPVYETEPWGVAADSQPSYFNAVILVKTTLPPASLLERGQAVEEAFDRVREERWGPRTIDVDIVAYADVLSDDPVLTLPHPRAHERAFVLAPWHDVDPEAQLPGAGPVAELLAGVGHEGVLPRADLELRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGX7</accession>
    <name>A0A7K2ZGX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03842 family LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000968">
        <property type="protein sequence ID" value="MYW31592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022315">
        <property type="entry name" value="F420_OxRdatse_CPS4043_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03842">
        <property type="entry name" value="F420_CPS_4043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="333" mass="36560" checksum="369E84111EAD4E65" modified="2021-04-07" version="1">MDFGLVLQTDPPASAVVGLMRRAERNGFRYGWTFDSAVLWQEPFVIYSRILEHTDRMIVGPMVTNPGTRTWEVTASTFATLNDMYGNRTVCGIGRGDSAMRVAGRRPNTLARLGEAIDVIRDLAEGREATVDGQPVQIPWVKDGRLPVWMAAYGPKALALAGQRADGFILQLADPFLTEWMIKAVRDAASDAGRDPDSVTICVAAPAYVGDDLDHAREQCRWFGGMVGNHVADLVARYGEHSRMVPDELTAYIAGRSGYDYSHHGRTGNPDTAFVPDEIVDRFCLLGPAEAHIEKLRALRDMGVDQFAVYNMHDAREATIDAYGSTVIPALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH08</accession>
    <name>A0A7K2ZH08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000975">
        <property type="protein sequence ID" value="MYW31636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="311" mass="34485" checksum="67643CA7137D3BCF" modified="2021-04-07" version="1">MRHTERELDRVLDTGPFHLALRTALSVRGLPLHRVQHHLAHRGVKLGVTSLSYWQQGVRRPRRPESLRAVRALEDVLALPDDSLLRLLRDRTEGAGGTDGERPAARSYRSLLESSGAVERLLAAMESPVDGGLHTVDHQERVRIGARRELACRSSLHVVRAHRDGVDRYLAIHRGDPGCDPARIVVRAGENCRTGRVRWDAEAGVLVAELLFDTRLRSGETYVFGYGFEDGTGGASDEYVRGFTFGGGQYVLQVGFDEGALPVRCRRFEQASAGAARAARRDLTLTGRHRTVHVVEEGVRPGLVGIDWDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH42</accession>
    <name>A0A7K2ZH42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000976">
        <property type="protein sequence ID" value="MYW31645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="302" mass="32923" checksum="92A3391FD469960F" modified="2021-04-07" version="1">MKVGCIGLGDIAQKAYLPVLSAVPGVELHLQTRTPATLDAVGDTHRIPAAARHTTLDSLLAEGLDAAFVHAPTAVHPEIVERLLEAGVATYVDKPIAYEYAESERLVNLAEERGVSLAVGFNRRFAPGYAQCAEHPRELILMQKNRVGLPEDPRALVLDDFIHVVDTLRFLAPGPVDHTTVRARIVDGLMHHVVLQLSGDGFTAIGMMNRRGGSTEEILEVSGRDTKRQVLNLADIVDHKGQPSIRRRGDWVPVARQRGIEACVHTFLDAVRAGKVLSAQDALATHELCERIVRDSLEQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHI7</accession>
    <name>A0A7K2ZHI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan DD-metalloendopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001020">
        <property type="protein sequence ID" value="MYW31816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="24494" checksum="5DF666F97DA39FDC" modified="2021-04-07" version="1">VPSACVMSVAGIAAASVSGISDEDKPEKTTSLAVADPSTVKAVAANNKLDSQLEQLSEGSDDFRQRASRTQERIDLKQRQVEEKKKREEEAARREALRPKFVMPVKQHGLSAYYGQAGVNWMSVHTGIDFPVGYGSPVMAATDGTVRTQYNSAYGNMAIVTMADGTETWYCHLSSTKIRSGPVKAGDVIAYAGSSGNSTGPHLHFEVRPGGGASIDPLVWLRSHGVNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHJ7</accession>
    <name>A0A7K2ZHJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001022">
        <property type="protein sequence ID" value="MYW31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7407" checksum="D93FDC98A9B08B80" modified="2021-04-07" version="1">MPIVVEIDVLLAERNLSVGEFAAAVGITPANIAVLKNGRAKAVRFATLEAICRVLECQPGDVLRYVPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHT5</accession>
    <name>A0A7K2ZHT5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glutamine synthetase</fullName>
            <ecNumber evidence="6">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_22000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001034">
        <property type="protein sequence ID" value="MYW31875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="7">
        <location>
            <begin position="90"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="37651" checksum="50D049017FC3324E" modified="2021-04-07" version="1">MTFKAEYIWIDGTEPTAKLRSKTKIMDGTPSGDVADLPIWGFDGSSTNQAEGHASDRVLKPVFTCPDPIRGGEDVLVLCEVFNIDMTPHESNTRAALRPVAEQFAGQAPIFGIEQEYTFFDGHRPLGFPEGGFPAAQGGYYCGVGADEIFGREIVEKHLDNCLAAGLGISGINAEVMPGQWEFQVGPLSPLEVSDQLWVARWLLYRTAEDFDVSATLDPKPVKGDWNGAGAHTNFSTKAMREGYEAIITACESLGEGSKPLDHVKNYGAGIDDRLTGLHETAPWNEYSYGVSNRGASVRIPWQVEQDQKGYIEDRRPNANVDPYVVTRLIVDTCCTALEKADQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHW7</accession>
    <name>A0A7K2ZHW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="23642" checksum="78CED90EB415E5FA" modified="2021-04-07" version="1">MVEQSETREASLRLVRRRSSVPEARALLRAKLGEWRAGEAPADVGELVLSELVTNALRVAVPGDRMIGVRIVCRERGASLRLEVSDAGGGRPVVRRPGELETGGRGLLLVEALAYRWGVDERSAGIGKTVWAEVVAPGATPASVAAELVDAEAEIAAATVRPGQSVRVWGAWCTVRSVRSERYASGGLAVVIGLDDGPGLRMDAAEPLLVRGGVPPTAAGDPVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHX0</accession>
    <name>A0A7K2ZHX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="357" mass="39236" checksum="B4859DCC80A76EE4" modified="2021-04-07" version="1">MSTPEQTEHLVLPGVLTAAEAAETVAALLAVQREDGALPWFRGHHLDPWDHTEAAMALDAAGEHEAAERAYDWLARHQNGDGSWYAAYHDGDPQQPTDRSRETNFCAYVAVGVWHHYLATGDDAFVDRMWPTVFAAIEFVLRLQQPGGQIGWKREADGTAVNDALLTGSSSVHQALRCALAIAERREEPQPDWELATGALAHAIRDHPERFLDKNRYSMDWYYPVLGGAVTGAEATARIQEGWDRFVVPGLGVRCVLPNPWVTGGESCELALALWVTGESDRALEILQSIQHLRAEGGLYWTGYVFEGNKAFWPEELTTWTAGSLLLAVAALGGDEATTAVFSGERLPFGLEPDCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI13</accession>
    <name>A0A7K2ZI13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="29374" checksum="CD3D6D0ADF07BCD7" modified="2021-04-07" version="1">MNIRSLTRGDGVVIGAAVVLFIASFLSLFSYDCSGGIDCSRLNSPNAWDSLGILMSVFLAGIIGAALVIVGRLAPRKVVGLDLGQFGTAFTVFALWTAFWTIIDVSSAGAGLILGLLGTIVLAAATVAGPLVPALKAPLVGAPKPAQAVQPPYGGQPGQGYGYPGAQQQQQQPYGAQPSQGYGYPGAQTGGQQGQPGQAEPAQAQTSQAQQAAPQSGAAPAGDFTPFWFAVPVARPLYGEDGAPNPIAELAPGTWYLAVEQRGQGLIAQTQDGRRGVLQDTTGIQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI37</accession>
    <name>A0A7K2ZI37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_22690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001065">
        <property type="protein sequence ID" value="MYW32004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="39"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="481" mass="52117" checksum="9FA79BA202488E4C" modified="2021-04-07" version="1">MTSAQVDEGQADKGRPGAEADGTETGGEGYQRGLGARQIQMIAIGGAIGTGLFLGAGKAIDRAGPSLILAYVLAGLVIFFIMRALGELLMYRPVSGSFSEYAREFIGPFFGFVTGWTYWLFWVVTGITEVTAAATYMTYWWDIPQWLSALVFTVILYGANLISVKLFGELEFWFSMVKVTAIVGMILICAGVLTLGFSDAGDTATVSNLWNDGGFFPNGIGGMLMTLQIVMFAFLAVELVGVTAGESKDPKTVLPKAINTVPWRIAVFYVGALIMILSVVPWSTFKPGVSPFVKAFEEMGLGIGAAIVNFVVLTAALSSCNSGMYSTGRMLRDLAMNGQGPRAFTKLTKNGLPLTGTTFSAALMLVGVWINYQWPGEAFNYVVSFATISGMWAWIMILFSQIRYRRLADRGVLPHSSFKAPGAPYTSWFALAFIGMVIVMMAVDKEARISLYCAPIWALLLGVSYLVLKSRDPENTAFAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI66</accession>
    <name>A0A7K2ZI66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001072">
        <property type="protein sequence ID" value="MYW32052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="275" mass="31366" checksum="E4554D77AD549339" modified="2021-04-07" version="1">MTFKPQPLTPYLSARHYFGSQQRRHREQAGLSLNQLAGIVNSSKSTLGRIETAELMPPPDIPSRLDIAFGTDQHFHELYELARREIHPDQYKRYMDFEYRAEVIEQYGAQALPGLLQTEDYARAFLRCQEDLSPEVVEERVTARMSRQGRLRSEQPPFRWAIIDESVLLRPMGSRDCMRDQLASLLEQVDTPSSKVQVMPFGAGSHSLLGGALTLLTLPDATSVAYEEGIEAGHLYEDPAAVKRWRRQYEVLRANSLTLDESAERIRTAMKGYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIK8</accession>
    <name>A0A7K2ZIK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16652" checksum="527CEC373B849452" modified="2021-04-07" version="1">MSESTTAVDPGTWIRGITIRQPWTSCILAGKDVENRPAPWSWRGLVLLHAGQATERAPMRDPLVATAIRGRALPTRAVIGVARLTDCHQDAVGTAPCSKWAQADAFHLVLADVQELALPIPWLHGQLGPWRPPQDLVDQVLLQLPHLAPEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIZ9</accession>
    <name>A0A7K2ZIZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-phospho-L-lactate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001150">
        <property type="protein sequence ID" value="MYW32333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="88" mass="8977" checksum="C77303FB9D1D9B07" modified="2021-04-07" version="1" fragment="single">MVTEGEIATNTDPAGLWSLVVPLKPLARAKSRLGRAAGELARPRLALAFAQDTVAAALSCSRVRDVVVVTDDAVAGAALSALGARIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ60</accession>
    <name>A0A7K2ZJ60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_24710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001155">
        <property type="protein sequence ID" value="MYW32382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="9">
        <location>
            <begin position="250"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="483" mass="49588" checksum="0D3FD38A91EB5EE3" modified="2021-04-07" version="1">MTADDAEELAVEQALALVGGRNQTRGRADDQARHRADDRTGDQTGDQMPHSQNPGEPAYPHPAPCTTPSPSPALPWDRARAVAARAGRGGPLAVVRLPLDRALGHVLAEPLAALTDLPSFDTSAMDGWAVAGPGPWTYEEGVSLLAGVGESPAADRLPDGTAVRIATGARTPGDTTAVIRSEHAHVDEARGLLSTRRPVVTGQDIRHRGQECRSGDALVPAGTVVTPAVLGLAAAAGYDALPAVPRPRVDVLVLGDELLAAGLPHDGLIRDALGPMLGPWLRALGAEVSGPRRLGDDAEALREALTSSDADLIVTTGGTASGPVDHVHPVLAALGAELLVDGVTVRPGHPMLLARLAPDGPHLVGLPGNPLAAVSGLLTLAEPLLAGLAGRPAQDAYRALVHADVPGHPHDTRLVPVVHRAGRAGGRDHVAPLRYNGPAMLRGIAGADGLAVVPAGGVRSGTEVEILDLPWAPATPWTEGCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ66</accession>
    <name>A0A7K2ZJ66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001134">
        <property type="protein sequence ID" value="MYW32299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="90"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22382" checksum="4372301B369322E1" modified="2021-04-07" version="1">MTSARETVLGRVRDALALAPTPATVVPRAYRTGRALPDPERLALFTDRLLDYRAEVHPCTADRTAQVVAEVLRDHGARRIGVPAGLDPRWLDAYDGEVCQDAADIPAPRLDSLDAVVTASAAGCAETGTIFLDGSPDQGRRALSLVPDLHLCVVDLSSVEAGVPEAVARLVPERPTTLISGPSATSDIELERVEGVHGPRTLVVVIRTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ92</accession>
    <name>A0A7K2ZJ92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001160">
        <property type="protein sequence ID" value="MYW32408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029827058" evidence="2">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="26276" checksum="F56ABEA4F5F85BB2" modified="2021-04-07" version="1" fragment="single">MAFAASVAFVTGAAPAAADPIETCTPTVGAIVAVDFGPFGGGVVRGCDTTPTTGYELLRDGGFTTEGTQHDGPGFICRIGNGAFNSGKQYPTPAKESCVLTPQAGAYWSYWIASPGQASWSYSPLGAMDRKPKAGDVDAWVFGATDVGGTTSRPAFTPDDVRAKGGAPDPSETPTDGPSVPVGKIDVPAAARWVTQQLHDGSHVVDEGSETPNYFLTTEAAYALAAAGGRSPALDKVVARLAAGTGEYAYAAGPKEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJT3</accession>
    <name>A0A7K2ZJT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4287 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001201">
        <property type="protein sequence ID" value="MYW32593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025629">
        <property type="entry name" value="DUF4287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14117">
        <property type="entry name" value="DUF4287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7746" checksum="4C10D0098B5F71A8" modified="2021-04-07" version="1">MTDAVKGPASYFPSIEKKYGRPVAEWKDLIRASPLTRHGELVTWLKTEHALGHGHANALVAHTLAEDKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKQ0</accession>
    <name>A0A7K2ZKQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class E sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001295">
        <property type="protein sequence ID" value="MYW32927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16900" checksum="D48DD60E681F88FD" modified="2021-04-07" version="1">TPRWDQAYAVLRIPRIGLTAPVAEGTSKGGVLDRGYVGHYTRTAQAGRAGNFALAGHRNTHGEPFRRLDRLRRGDRITVETRDAVYTYTVDKSLARTAPSDSGVIAPVPRSNITTSVGYSEPGYYLTLTTCAPEFSSRYRLVVWGKLTAMRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKR8</accession>
    <name>A0A7K2ZKR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxA</name>
        <name evidence="4" type="ORF">GT040_27625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001297">
        <property type="protein sequence ID" value="MYW32942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="16399" checksum="D59B66AD616D7844" modified="2021-04-07" version="1">MNTTRTTTVTCPHCGRDNRLPVAAEGRPTCGHCKQPLPWVVDAGDGDFTEVADNAVQPVVVDLWATWCGPCRMVSPALEQVARDLAGRIKLVKVDIDKNPGVSQRFEVQAVPTLLVQDHGETVARQAGAAPAHVLRQWVEQALEGRQATAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKT5</accession>
    <name>A0A7K2ZKT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MsnO8 family LLM class oxidoreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001265">
        <property type="protein sequence ID" value="MYW32859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="349" mass="37618" checksum="BA45820F51FE8743" modified="2021-04-07" version="1">MRLSVLDQSPVPEGTPPATALRNTLELSILADRLGYHRYWVAEHHASPFQAGAAPEILIGQILARTSGIRVGSGGVLLPYYSPFKVAEVFRVLHALYPGRVELGVGKAHLSKDPVVRALRRDAADPTGGGDFPDKVAELRSFLVGDEFPEGHPYRGLLPSPPSPGHPELWVLGSSVSSAEATARAGLSYAYAHFLGPDTTVEAVRRYREEFVPHLVDGKPIGGPRVVLGIGVYCAETEAEAHALLAGHRLFRQRMERGIMRPVPSTQQAIEELGAEAALAGDPGPGHPDHDPYVRNAVGSPEQVRAHITALTEATGADEVILINSIHDHKARLRCYELVAEVFDLAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLH3</accession>
    <name>A0A7K2ZLH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_29090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001353">
        <property type="protein sequence ID" value="MYW33214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="310"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW33214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="549" mass="60709" checksum="0D901ECB21C8ECC2" modified="2021-04-07" version="1">MSTEQSTRHDTGKDPVRSDVAARLSVQNWVHLILGGFIVVVCGCLVTGGLVLARMSDHTTDLVDRIQPARSVSFQLQNALLDQETGVRGFALTGDDSFLEPYEAGKAAERDRLTRARQLVGGQKQFAEDLDAIETAARQWRENKAEPLLNLVREQGPSVDGASAQLQSSKTDFDALRRAYGAQQTHLSEARDTVRAELNDARTTRDQVLFALVAVFVLTMVALSVLLHRVVGVPLNRLRAASERVRSGAFDQRIEIKGPSDVQAVAGAVEDMRRRLVDELDGAQARETLLAEQTEELRRSNSELEQFAYVASHDLQEPLRKVASFCQLLEKRYGKELDDRGKQYIAFAVDGAKRMQVLINDLLTFSRVGRVNEGRQPVDLDRALDRALGNLTLAVEESGAVIERPRELPELLGDGTALTMVWQNLIGNAVKFRREDVECRITVDCVREDDDWHLSVSDNGIGIAPEFADKVFVIFQRLHARDEYEGTGIGLALCRKIIEFHGGRIWLDGEPGEGTRIHFTLPATPEAPQHTTAEPLAPALTVSQPGDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLI4</accession>
    <name>A0A7K2ZLI4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_28520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001320">
        <property type="protein sequence ID" value="MYW33109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="10">
        <location>
            <begin position="358"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW33109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="677" mass="72872" checksum="CCE319DFDF147ECD" modified="2021-04-07" version="1" fragment="single">VRAVDTVRLLAADAVQKAGHGHPGTAMSLAPLAYLLFQQVMRHDPADDQWLGRDRFVLSCGHSSLTLYIQLYLSGYGMELTDLEALRTWGSSTPGHPEYRHTRGVEITTGPLGQGLASAVGMAMAARRERGLLDPDAPAGASPFDHHVYVVASDGDLMEGVTSEASSLAGHQELGNLVVFYDSNHISIEDDTDIAFSEDVTARYAAYGWHVQTVDFTRTGDYVEDVDALLAAVEAAKSESGRPSLILLRTIIGWPAPTKQNTGKAHGSALGDDEVAATKKLLGFDPEADFTVEDDVLTHARAVRERGAEAHRAWEPRYQEWRTAHPERAALLDRLLEQKFPDGWTDSLPVFDADPKGIATRKASGDVLSALAPVLPELWGGSADLAGSNNTTMEGEPSFVPEGKQTGEFPGNPYGRTLHFGIREHAMGAVLNGIALQSLTRPYGGTFLIFSDYMRPAVRLAALMKLPVTYVWTHDSIGLGEDGPTHQPVEQLAALRAIPGLDVVRPADANETSVCWRTVLEHHDRPAGLALTRQPLPVLERGEGAYAPASGAARGGYVLADSGSGTPDVILIGTGSEVHIALEARELLAAEGHDARVVSLPCREWFADQPYAYQDEVLPPAVRARVSVEAAVAQGWRDIVGDAGRMVSLEHFGASAPYERLYEEFGITPRAVADAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLL0</accession>
    <name>A0A7K2ZLL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_29120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001354">
        <property type="protein sequence ID" value="MYW33220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="307"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="425" mass="45013" checksum="BE3A3144573CF1D7" modified="2021-04-07" version="1">MTTLPSGFARARRWLRDHPLAFDAALAFCVLIAMICGSFADPGKGHGPTFGTRTPEAFSVLLMVLAASALVLRRRHPMPVLAVTGVLTATEYIFMDPPAPVVMSTVIALYTVASRTDRPTTWRVGLLTMGILTVAAMAFGSTPWYSQENLGVFAWTGMASAAGDAVRSRRAFVDAIRERAERAERTREEEARRRVAEERLRIARDLHDVVAHHIALVNVQAGVAAHVMDKRPDQAKEALAHVRDASRSALNELRVTVGLLRQSGDPEAPTEPAPGLAVLDELVDTFRNAGLPVEVAGADRGPGLPAAVDLAAYRVIQEALTNVRKHAGAGARAEVSVVRVGTTAEITVLDNGRGSAAGRPGAESTPDGGGHGLLGMRERVTALGGALTAGPRYGGGFRVHAILPLEARTGEPEQPGPAAATGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLP3</accession>
    <name>A0A7K2ZLP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sel1 repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001359">
        <property type="protein sequence ID" value="MYW33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8158" checksum="1ADFA2C5AD140567" modified="2021-04-07" version="1" fragment="single">MGLGFFLLPAGGVLSLTGVWLGSDTLINLSWIMWAAGILLLIAQRYRRPPDPRQLAVAAAAGDARAVRGLRTLALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLX4</accession>
    <name>A0A7K2ZLX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="82" mass="8266" checksum="29883CCB346B89A8" modified="2021-04-07" version="1">PAPRFDGYGPVAAAPTPRGPVLLGRDAEGALRLRTTGSTAVRSRGPVALDGAALHLGADGAPTVVGFGPDAAPWIWRPRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM13</accession>
    <name>A0A7K2ZM13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="5" type="ORF">GT040_29935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001386">
        <property type="protein sequence ID" value="MYW33372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="35"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="375" mass="40800" checksum="1B450B04B1295D6D" modified="2021-04-07" version="1">MTSNSAPLNPWDELPIRDELRGQSPYGAPQLDVPVRLNTNENPYPLPEALVDRIAERVREAARGLNRYPDRDAVELRTELARYLTRTAGHEVTAAHVWAANGSNEVLQQLLQTFGGPGRTAIGFEPSYSMHALISRGTGTGWISGPRNDDFTIDVEAARAAIAEHRPEVVFITSPNNPTGTAVNADTVLALYDAAQAAGPSIVVVDEAYGEFSHHPSLLPLIEGRRNLIVSRTMSKAFGAAGLRLGYLAADPAVVDAVQLVRLPYHLSSVTQATALAALEHTDTLLGYVAQLKSERDRLVAELRATGYEVTDSDANFVQFGRFDDSHAVWQQILDRGVLVRDNGVPGWLRVTAGTPAENDAFLDAVRELKKEHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMD5</accession>
    <name>A0A7K2ZMD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15863" checksum="245E8809B13E8317" modified="2021-04-07" version="1">MVTKQFSGSPDEADLRRADSLAREIFSDVANKWTLLIIEALGDRTLRFSEVLKEVDGISHKMLTQNLRMLERNGLVERTVYPTVPPKVEYTLTEPGQGLRGTVHLMCDWTQRHLGHIEEARGRFTSPTDATSGPLRASVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNA6</accession>
    <name>A0A7K2ZNA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pepN</name>
        <name evidence="16" type="ORF">GT040_32255</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001483">
        <property type="protein sequence ID" value="MYW33817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="232"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="535"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW33817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="858" mass="94548" checksum="962D4DFE3A19FA3F" modified="2021-04-07" version="1">MPGTNLTREEAQERARLLTVDAYEIDLDLSGAQEGGTYRSVTAVRFDSAEAGAETFIDLVAPAVHEVVLNGEALDAAAVFRDSRIALPQLRAGANELKVVADCAYTNTGEGLHRFVDPVDEQAYLYTQFEVPDARRVFASFEQPDLKATFQFTVKAPAGWTVISNSPTPEPKDDVWTFEPTPRISTYITALIVGPYHSVHSSYEKDGQSVPLGIYCRPSLAEYLDAEDIFAVTRQGFAWFQEKFDYAYPFAKYDQLFVPEFNAGAMENAGAVTIRDQYVFRSKVTDAAYEVRAETILHELAHMWFGDLVTMEWWNDLWLNESFATYTSIACQADAEGSKWPHSWTTFANSMKTWAYRQDQLPSTHPIMADISDLDDVLVNFDGITYAKGASVLKQLVAYVGKDAFFQGVQAYFKAHAFGNTRLSDLLGALEKTSGRDLKTWSKAWLETAGINILRPEIETDADGHVTSFTVLQEAPALPAGAKGEPTLRPHRIAIGAYDLDESGKLVRTDRIELDVDGERTAVPELVGKARPAVVLLNDDDLSYAKVRLDEESLRVVTEHLGDFTESLPRALCWASAWDMTRDGELATRDYLSLVLSGIGKESDIGVVQSLHRQLKLALDLYAAPQSREAVLNQWTEATLAHLRAAEPGSDHQLAWARAFAATARNPQQLDLLQSLLDGTESIEGLTVDTELRWAFVQRLAAVGLLDEEEIAAEYERDRTAAGERHAATARASQPSEEAKAQAWASVVESGELPNSLQEAVISGFVQADQRELLAPYTEKYFASVKEVSDSRSHEMAQQIIVGLYPALQVSRETLDATDAWLASAEPSAALRRTMSESRSGVERALKAQAADAAAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZND6</accession>
    <name>A0A7K2ZND6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na+/H+ antiporter subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001487">
        <property type="protein sequence ID" value="MYW33865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13097" checksum="5097F76FED191319" modified="2021-04-07" version="1">MNAWLQILDTAGALLVLLGAAICLLGVIGMLRLPDVLSRSHAATKPQTLGMLLVLAGVALRLRTGMDLATLALIGFFQMLTGPVASHLVARSAYRTGQVQHEELLFDELDEQLTDGRQPPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNK4</accession>
    <name>A0A7K2ZNK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001497">
        <property type="protein sequence ID" value="MYW33920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="157"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="402" mass="42045" checksum="86BE74796EEBC09A" modified="2021-04-07" version="1">MSLGKGRRAPGRKTVLPGTDAGATAATGRIGNWALAGLVLLLSALIVLLDVVTGEDLRVVPLLVVVPALASVFCSLRQTVWVAVWITAVVVGSGLGGDGTFWDFVFGIGFTMLACALGVAACAARIRHATEMDRLRSAAVALQRQILRPLPVITDQVFAYGIYEPIEEDRFVGGDIYEVVQSPYGTRVIIGDVQGKGIAAIGAGFAAIAAFREAAVREPTLTGVVEALEAAVVRHNAFSAQTGEAERFVTALVLGFDVEDRVQAVNCGHLPPRLLHEGRAAAVRLERTYVPLGLAGLSRETRTAESFALPPGATLLVVTDGVTEARDAARAFYPLDRRLAGWAGHGPRELLDALHVDLEAFTGGIRRDDVAALALGRAPGDGGPLPAAAADEVRPVAGAVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPA8</accession>
    <name>A0A7K2ZPA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enhanced serine sensitivity protein SseB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001543">
        <property type="protein sequence ID" value="MYW34099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB_C" evidence="2">
        <location>
            <begin position="121"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="249" mass="26952" checksum="FEA2924763EA2D1D" modified="2021-04-07" version="1">MLRQVSPGRYDAYEALLAALAGGQVWMLLWHGTAGSPDAQYGSMEVEGLGYAPCVTSAQELSASGWSRAHELVSGRDISRTLFPDRWGIWLNPHAPGGGVGIPWLDLRRISTGLDRLPAGPLRLTEPAVELPQFYAQLTQNAHRTPAVRSLRRAWVHPAVGVPYLAIGLDLYDTGRAAVDAVRAMMRQSIGAVPDGLPVSTVAMSDEYDPVAMWLRANARPFYDREAHAPAGPPPAAAPGYGYPPQQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPE4</accession>
    <name>A0A7K2ZPE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XdhC/CoxI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001574">
        <property type="protein sequence ID" value="MYW34225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_C" evidence="1">
        <location>
            <begin position="32"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="21761" checksum="297697B7433BA2A8" modified="2021-04-07" version="1" fragment="single">GRTGTVTLSEDGSHCPGGLTLLVECSVEPPRMIVFGAVDFAAALVRAGKFLGHHVTVCDARPVFATRARFPEADEVVVDWPHRYLRGTRTDGRTVVCVLTHEARFDVPLLTEALRRPAAFVGAMGSRRTHEDRLRRLREAGLDEDELARLRSPIGLDLGARTPEETALSIAAEIVAARRGGTGLPLTGGAEPIHRDLARSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPI3</accession>
    <name>A0A7K2ZPI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001552">
        <property type="protein sequence ID" value="MYW34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="15997" checksum="51A0229541D423F5" modified="2021-04-07" version="1">DEPTTGLDPRSRQELWEVVRGLAERGAGVLLTTQYLEEADRLADRIVLLDKGSIAAEGSAADLKGRVAGHRLDLVLTSRDAYLRLTGRAVHHSPETLTVGLPTDGSAAHVRALLDEIDPAGTEIDRFTLHSATLDDVFLALTSEVPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPY8</accession>
    <name>A0A7K2ZPY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001612">
        <property type="protein sequence ID" value="MYW34402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="7716" checksum="C5FCA6CED4C4A8D8" modified="2021-04-07" version="1" fragment="single">MTQWTSTVGATQLARQLQAQQPRPTGPAGRKPPAYRALADGVRLLVLEGRVPVAARLPAERELALALSVSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPZ8</accession>
    <name>A0A7K2ZPZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001622">
        <property type="protein sequence ID" value="MYW34420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029497978" evidence="1">
        <location>
            <begin position="45"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16545" checksum="1FCF803E075F2E0E" modified="2021-04-07" version="1">MRKSADRKRTARLSRNTRLSRRGLALAGAGAALATLVSGTPASAVGNGGCTNIQQGLGFLCARWDGQSHTYFDTIQGSFHSTLGVGNPRIHVRILDAQNREMFSRDRTWGGNRHDEEARFDVTVLMPRSASRVCASLYEGGGLVDTACAPVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ84</accession>
    <name>A0A7K2ZQ84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001622">
        <property type="protein sequence ID" value="MYW34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029853712" evidence="2">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="10876" checksum="4CA9DB4D5C774BF0" modified="2021-04-07" version="1">MRFRTVAASAALVLFAMTGAASCSSSSGAAETPQPPAGPATSVESAPVEGMAGRIETGKRAGVPTLDGQIVVGPSECAVPVEEIPAECALDLSFDEIGVGESADDAPDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQF4</accession>
    <name>A0A7K2ZQF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001641">
        <property type="protein sequence ID" value="MYW34572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011340">
        <property type="entry name" value="Cys_dSase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01976">
        <property type="entry name" value="am_tr_V_VC1184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="22"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="401" mass="42538" checksum="50B8A1D4FBA82C1A" modified="2021-04-07" version="1">MSYDVSALRAQFPALRAGTAHFDGPGGTQTPAPVIAAFTEALSRPLSIRGTTLPGEIHAETIVGDFRQALADLLGADPDGIVHGRSSTQLTYDISRVLSRSWAPGDEVVVSRLDHDANIRPWVQAAERVGAVVRWAEFDPATGELPTEAVGALLTERTRLVAVTGASNLIGTRPDVAAIGELVHRAGALFHVDGVHLTAHAFVDVERIGADFFVCSPYKFFGPHHGVLAARPELLGTLRPDKLVPSSDAVPERFELGTLPYESLAATRAAVDFIADLGDGGTADGRRDRLRSAYAAIEAHENALLEVAEKGLGELGGVTVRSRAAERTPTLLLTFEGRDASDAYRFLARSGVHAPAGSFYALEASRHLGLGDAGGLRVGLSPYNDTDDVERLLTGLAEFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQT3</accession>
    <name>A0A7K2ZQT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="12046" checksum="7767E05832028F2F" modified="2021-04-07" version="1" fragment="single">MRQRPIGTATRGTTNPNRLRRMDRWIAAAHGPALRRAETPVAVDLGYGAAPWTAVELLARLRTAEPRTAVAGIEIDPERVAAAKPYEREGLTFVHGGFEIPLAARPVLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR23</accession>
    <name>A0A7K2ZR23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001688">
        <property type="protein sequence ID" value="MYW34795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="48" mass="5077" checksum="557EBEC99BA45197" modified="2021-04-07" version="1" fragment="single">MSGRLPSGCWQRIRNFGGDTAMSYNQPGPYGGQPPQGQPGPYGQQPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRE2</accession>
    <name>A0A7K2ZRE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001704">
        <property type="protein sequence ID" value="MYW34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="167" mass="17359" checksum="A16A5782468932F0" modified="2021-04-07" version="1">AEALRERWREAGGPLPEDADDETALAALLAAAYPPPGGPAPDQVALALLDETAECLGAALADLVNLFLPERILLGGWAGLLLGPHLLPDIRRYANEYALRHAAARTTIEMGRLGPDAVTVGAATLPLADFLTRGGSRPAPGARPDGTGAPPRTATETVRNRSRTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRJ4</accession>
    <name>A0A7K2ZRJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MbtH family NRPS accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001747">
        <property type="protein sequence ID" value="MYW35020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="2">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="9114" checksum="E32C709BE232C815" modified="2021-04-07" version="1">MSDTTMYQVVVNDEEQHALWPARTAPPAGWRVEGFRGSEEECMAHVDRVWPDIRPLSLRRRLAERADGTAPAAAPTDSPAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRT2</accession>
    <name>A0A7K2ZRT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_38855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001771">
        <property type="protein sequence ID" value="MYW35084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="105"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="353" mass="39158" checksum="B8A4BF53C68B2260" modified="2021-04-07" version="1">MDLPVMPPVKPMLAKSVSKIPPGMSYEAKWDGFRAIVYRDGDEVEIGSRTGKSLTRYFPEMADAVRENLPPRCVIDGELVIAHGGRLDFERLSERIHPADSRVRMLAEKTPASLIAFDILAVDDTSLLSTPQVDRRAVLTAALSGASAPVLLAPSTTDIELAREWFDRYEGAGLDGIVAKPPDLPYRPDTRVMYKIKHERTADVVVAGYREHKSGPVVGSLLLGLYDTGGVLQHVGVCAAFPMKRRAELAEELAPLRCEFTDHPWGAWADAAAHEAARLPGTQNRWSGKKDQSWVPLRPERVCEVAYDHMEGDRFRHTTQFRRWRPDRTPAGCTYAQLEEVVSYDLAEVLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRT4</accession>
    <name>A0A7K2ZRT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001757">
        <property type="protein sequence ID" value="MYW35042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="35"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="434" mass="49448" checksum="47E3F9A52B7E28D3" modified="2021-04-07" version="1">MLINFRVENFRSLKDPQELDLRPVYREGSDSLTVSAIYGANASGKSNVLRALEFMHDAVTDQRGWNHGNKIRLAPFLLDQESREKPTSFAVELVIDRIKYDYGFTASRERIIEEWLHAYPKKKKRVLFERDGDEYYFGPSFASARAEVIKEITAPVGLYISTAAKANEKSSRAVFSWFSERLWFADDAEGSRAMQRGKTMSLLRNPGKKEAVERLLSAADLGISGTRVEDFEIEFQEDPESSEPDASFRVTYKDGKATILYRGKRPDLPPNLRTLIETDSSLAFRHRGKATHEFTLDQESRGTQTWFDVVGMVIQALDEGHTLVVDELDTSLHPLLLAQMIRLFQKEDSNPHRAQLIFTTHDASLMGRNRGEELLKRDEIWFTQKNPETGSTELYPLTDFKPRDGLNWEKRYLGGSVGGIPYVSETAFDEALSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRY7</accession>
    <name>A0A7K2ZRY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Extracellular small neutral protease</fullName>
            <ecNumber evidence="4 6">3.4.24.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">snpA</name>
        <name evidence="10" type="ORF">GT040_39180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase M7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="4 6"/>
    <dbReference type="EMBL" id="WWKE01001779">
        <property type="protein sequence ID" value="MYW35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016573">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029998607" description="Extracellular small neutral protease" evidence="6">
        <location>
            <begin position="30"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="22651" checksum="AB758927E33D449D" modified="2021-04-07" version="1">MRHLRTAIASAIAGLGLVAALGTAPAVSAAPAPAVSTPSTIAAYTGSAENAAANKAFFDAVMKSVAEKRAANPRALAVTVTYSTASAPSFRTQIANSTRIWNSSVSNVRLQEGSNADFTYREGNDSRGSYASTNGHGRGFIFLDYRQNQQYNSTRVTTHETGHVLGLPDTYSGPCSQLMSGGGPGPSCTNAQPDANERARVNYLWQNGFAAALAGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS52</accession>
    <name>A0A7K2ZS52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001781">
        <property type="protein sequence ID" value="MYW35162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="103" mass="11321" checksum="E120CAF8587780BF" modified="2021-04-07" version="1">VRNRRLALLWLRRQALRLANAHGDRAALEREAVRLPTADVRAVLFHGTDAPESLRCWATDACRQDDAIRTLEAGFPLHFTVADPAVGLCVTLAGWRTAPAAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS92</accession>
    <name>A0A7K2ZS92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_39580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001796">
        <property type="protein sequence ID" value="MYW35215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="250" mass="27562" checksum="0DBF66EEF8991505" modified="2021-04-07" version="1">MVEIRSVHKNFGSLEVLRGVDLSVRPGEVTVILGPSGSGKSTLLRTINHLEKVDQGWISVDGTLVGYRRDGNKLYELREREVLRQRTKIGFVFQNFNLFPHLTVLENIIEAPVSALRRPRKEAAESAEKLLARVGLADKASSYPAQLSGGQQQRVAIARALALEPKLLLFDEPTSALDPELVGEVLDVIKDLAHGGTTMIVVTHEIGFAREVADTVVFMDDGRIVEQGRPADVLDHPAQERTRAFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSL0</accession>
    <name>A0A7K2ZSL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_40410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001839">
        <property type="protein sequence ID" value="MYW35371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="25565" checksum="1494D15FFE886AD4" modified="2021-04-07" version="1">MKPHSAGPSPVIELRDATKSYPGGVTALRAVNLTVHAGELLAVAGPSGSGKSTMLNVMGTLDKPTTGTVEVAGYDVSALSDARLSALRARHIGFVFQHFHLAPGRDAVDNVADGLLYAGVPLKERRRRAREALARVRLAHRASHTPDQLSGGEKQRVAIARALVGAPGLLLADEPTGALDTASGAIVMELLHELNASGTTVCVITHDHEIADALPRRVRFKDGEIVSDTRCTKPTAPTEEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSP8</accession>
    <name>A0A7K2ZSP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coagulation factor 5/8 type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001840">
        <property type="protein sequence ID" value="MYW35375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="333"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="469" mass="50666" checksum="5657184AC32C63A2" modified="2021-04-07" version="1">FWLQPGGGPGSGGCVNYVTDAAYKSTMLTEIAKWVETYKSHPATLMWNVGNESVLGLQNCYSGAELEAQRNAYTTFVNDAAKRIHAIDADHPVTSTDAWTGAWPYYKRNAPDLDLYSMNAYGDICGVRKDWVDGGYTKPYIITETGPSGEWEVPDDANGVPDEPTDVQKRDGYTKAWDCTIGHQGVALGATLFHYGLEHDFGGVWFNLIPGGLKRLSYYSVKKAFTGSNTGDNLPPVISGMTVTPAGSAPAGGEFTVRADIRDPENDPVTNKIFLSGNYANGDKGLIPAQFRSTGNGTFAVTAPEKLGVWKVYIQSEDGKGNAGIETKSVKVVAPPMTGTNVALGKRTTASSSQASYGDCPCPPERATDGRLDTRWASDWSDPQWIAVDLGARLPVRNLQLVWDPAYAKSYGVQVSDDGTSWRTVHTTTTGNGDVDTIALTETARHVRLQLTARGTGWGYSLHEFGVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSS9</accession>
    <name>A0A7K2ZSS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriocin biosynthesis protein SagD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001854">
        <property type="protein sequence ID" value="MYW35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="10505" checksum="BE69D551582FBAA1" modified="2021-04-07" version="1" fragment="single">MADSTGLLAELLEAGLARHGRARSATAPVDVQPLGLRDAFRSEEKPSASAVPVRYYGRHAVIGPLPASADTRQLPCARCLERRWQAVRSVALREALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSU3</accession>
    <name>A0A7K2ZSU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1772 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001829">
        <property type="protein sequence ID" value="MYW35279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="15957" checksum="CCCD08EAB4B1AE18" modified="2021-04-07" version="1">MLNALEVCTTVVVGLMVGVEFAVAFVINPILNALPGDNGLLGRAHGGRMLGAVMPFWYIGSLVLSAIWAAARWTTGGAGLVAIAAGLLIVSVVMSVLLLVPINNRGKTWTAENRPEDWKEQMNRWDRFHYLRVAVIIAAFTLLVTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSY7</accession>
    <name>A0A7K2ZSY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001848">
        <property type="protein sequence ID" value="MYW35418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="13200" checksum="EDDA52FC70A7F8E9" modified="2021-04-07" version="1">MGTVQKAYGECGLSYNRCRWCGTASFRRLLCPVCASSELEPERTTGHGVVVRTAVVHRYTEAARNESLVRFPEGFVFRCQVVGAAPQMVTVGARVKPLAGEDPDSGAVVLELCEPPGQRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5S9</accession>
    <name>A0A7K2Z5S9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">groL</name>
        <name evidence="9" type="synonym">groEL</name>
        <name evidence="13" type="ORF">GT040_00035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="344"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="476"/>
            <end position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW27700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="540" mass="56700" checksum="E2CFB52CEFAF5EAC" modified="2021-04-07" version="1">MAKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPMALKRGIEKAVEAVSAALLEQAKDVETKEQIASTASISAADTEIGAKIAEAMDKVGKEGVITVEESQTFGLELELTEGMRFDKGYISAYFATDMERMEASLDDPYILIVNSKIASVKDLIPLLEKVMQSGKPLLIIAEDVEGEALSTLVVNKIKGTFKSVAVKAPGFGDRRKAMLADIAILTGGTVISEEVGLKLENAGLDLLGRARKVVITKDETTIVDGAGDSEQVQGRVKQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLQASAVFDKLDLTGDEATGANAVKLALEAPLKQIAVNGGLEGGVVVEKVRNLPIGHGLNAASGEYVDMIAEGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEKAGAAAPGGMPGGDMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z603</accession>
    <name>A0A7K2Z603_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000003">
        <property type="protein sequence ID" value="MYW27733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="51"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="33771" checksum="604BE158C5E8075D" modified="2021-04-07" version="1">MRARYGVPLKVTAVGAAVGAAGLAYAAGFEARSFRLRRVTVPVLPHGARPLRVLQVSDIHMVSGQRKKRAWLQSLAGLRPDFVVNTGDNLSDPEAVPEVLDALGPLMEFPGVYVFGSNDYYGPKLRNPGRYLLEKIQGKHGLNGNEPAVGVVHNPWEPMRDAFDEAGWLNLTNTRGRLKLDGTEIAFTGLDDPHIKRDRYAEVQGGPETGADLSIGVVHAPYLRSLDAFTADGYPLILAGHTHGGQLCIPFYGALVTNCDLDTDRVKGLSTHTAGDHRAYLHVSAGCGTNRYTPVRFACPPEVTLLTLVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6V7</accession>
    <name>A0A7K2Z6V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000079">
        <property type="protein sequence ID" value="MYW28043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M6" evidence="2">
        <location>
            <begin position="381"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="547" mass="59501" checksum="7145C437E85FB769" modified="2021-04-07" version="1">GSAARAGLLQGPLDQLVREAEAYLADSPKHPWYAGAVLLAGRGGTVALHRPIGQAVRYAAYDEATDTGVEFPADQQIAMAEDTVFDLASISKLFTSILAVQQIERGALELEASVASYLPEFSGGGKQAITVRQLLTHTSGFRSWIPLYQEPTREGKLRMLWNEVPASTPGSAYLYSDLNLISLQLILERITGRTLDALLRDEITAPLGMHRTRYNPPASWKPKIAATEDARLPWSGLERGLVWGEVHDENAYSFDGVAGHAGVFSCAWDLAVLARTLLNGGVYGRARILSEDSVDLLFTDFNTAFPGDEHGLGFELYQHWYMGAMATPRSAGHTGFTGTSLVLDPSTDTFLIVLGNSVHPVRSWRSGSAPRVATANQLARAVPVRPERGRTAWFSGMASASTATLTLPVLRLASARSRLECALWWDTEPGADRLVLEVSAGGEWQPVPFTTVGPGPGHHRPDPRPHPEGWVSGWSGRVWHRVEADLSPWRGKGVQLRWRYTTDQLYVGRGAYVDSLRVRDGGATVFDSGRPRDAGRIAATGWGLSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7A9</accession>
    <name>A0A7K2Z7A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_02785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000118">
        <property type="protein sequence ID" value="MYW28224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="587" mass="61159" checksum="5FC5B95A375DE77D" modified="2021-04-07" version="1">MMLHPELLRAARTARRPLGGATALLAAVTLTHLAQAVLLAVVLSRIAQGDTSGLAPLLLSVLAVVLVRAALGRAQRLTAVTAGAAVRIRLRDTLLSRLGELGPTAITGARAGAVRATLVDGVEGVDAYVSRYLPQALITSAVPPLLLVAVALIEPYAALALGLALLLALFGPRGWDRLLARRGKEHWDSYEALAADYLEALQGMATLRAAGAVGRVRDRLEQRSAALHRATVAKLRVSLADTGLTDLAVQGGTAAAVLVACSSAATGRTATTGTYLLLMLASECFRPIRDLSREWHAGYLGVSAADGIAALRTAEPAVADRGTVQARWDTAPEIRFADVHFTHPSSERPALDGVTFTAPAGRTTAIVGPSGAGKSTLLSLLLRQRDPDSGRVTIAGTETAAHTLASLRRGIAVVSQETYLFHATIAENLRVARPDATDAQLRSAARAAGIHQEITAFPEGYDTLVGERGATLSGGQRQRLALARALLADAPVLILDEATSAVDERGEARIVRELPAASRGRTCLVVAHRLDAVRHADHIVVLDGGRVEASGDHGGLLAGGGVYASLIAAGRTAQEQAGRTAQEEHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7E9</accession>
    <name>A0A7K2Z7E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000128">
        <property type="protein sequence ID" value="MYW28252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="168" mass="17361" checksum="F776AEC0FB348F75" modified="2021-04-07" version="1" fragment="single">MLGEYRISGRRASEIAASVERGVGSGDLAPGHVLPPMRELAERLEVNPNTVAAAYRTLRERGVIETAGRRGSRVRPRPASTSRGSLRIEAPPGVRDLGEGNPDPALLPELGPALAAAAAVHAQSPGLYGEAPVVPEFAAYARTAMDADGVPEGPVAVASGALDAIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7G9</accession>
    <name>A0A7K2Z7G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysE family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_02940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000129">
        <property type="protein sequence ID" value="MYW28255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="22622" checksum="01FBDBC21E17F050" modified="2021-04-07" version="1">MVELTGVLGVAMVALGMVLTPGPNMIYLVSRSITQGRRAGVVSLGGVAVGFLVYLLATNLGLSVVFIAVPELYIAVKLAGAAYLAYLAWTALKPGGVSVFAPQEMPHDSPRKLFTMGLMTNLLNPKIAIMYLSLIPQFINLDSGHVLFQGFVLGSVQIAVALTINLSIVLAAGSIAVFLARRPSWLKVQRYMMGTALALLAVSVALDTSMPASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7H8</accession>
    <name>A0A7K2Z7H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11624" checksum="E338863FC7ECB03F" modified="2021-04-07" version="1">MTDTSIAEAQENEATGTYGTASVSGVELRVKPANQWRPSYMRALRQGDYDTWAAGVLHEDDVQTFIDLDPTFDEINEFTSAAMETTGDTAGKSSGRAARSRSTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7M9</accession>
    <name>A0A7K2Z7M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="130" mass="14384" checksum="6643399D5A5821A8" modified="2021-04-07" version="1">MATAQYGTRTRTVEETVVVLTLTEDEADALEALVLGESGAVMERIYRALRQTEPPAPAADTFEYDGVTYELGATYRDRVGDKFTFEAGTAGPDRTPRGRFWDSDQGKFGDLTWTLREVVSSWAPLTKVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7R5</accession>
    <name>A0A7K2Z7R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000155">
        <property type="protein sequence ID" value="MYW28400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="186" mass="20582" checksum="D39E2D3934310DC0" modified="2021-04-07" version="1">MIVWLNGTHGAGKTTTSALVQQLLPDSRVFDAEKVGETLMDITPALCRTDNFQHWPPWRSLVVETARQVLDYTGGTLVMPMTVLVEPYWREISSGLARHAIPLRHFVLHADQETLRGRIEGDTDMGPSAFRFRHLEPYAEAARTWLHSEAEVVDTTHLTPAEAAEQIAGSVRRDVGTRGARGAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7S6</accession>
    <name>A0A7K2Z7S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000156">
        <property type="protein sequence ID" value="MYW28404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="293" mass="30432" checksum="0C7C76167CD7305A" modified="2021-04-07" version="1">VTGATGRQGGAVTRALLAAGVPVRALVRDPHAPRAKAVEALGVELVTGDLSDRSSLDPACAGVRAVFSVQMPPMDESGVDFAAELAQATHLIEAARAAGVPQFVQSSTSGVGRHTETPGWAEGRWAAMEGYFATKQAIMEKVRGAGFARWTVIKPAFFMDNLPQLAPQGPEGGLATVLLPDTPLALVATEDIGAAAAHAVLEPDRFHEVELELAGEVLTMTEVARTLSTAWGVPVEAPTMSLDEALAAGMPAWGAGHVWSNAVLQPARPELALELGIPVTSFAAWAQTHLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7U3</accession>
    <name>A0A7K2Z7U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000150">
        <property type="protein sequence ID" value="MYW28378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="2">
        <location>
            <begin position="75"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="283" mass="31409" checksum="A7332F9F52C9A19F" modified="2021-04-07" version="1" fragment="single">MGRADARRARAQESRRAAKSGGIRRLFTWKKLLGTFFGIVLLGMGAFGALYLYVDVPAPNALAERQSNVYQYSDGTVLARSNGDVNRQIVDLAQVPKEVQHTFVAAENKTFYEDDGIDLKGTTRALLNTLSGKGKQGGSTITQQYVKNYYLTQDPTISRKLQELVISLKVDQDQSKGQILAGYINTAYYGRGASGIQAASQAYYGIDAKDLNVSQGAYLASLLQAPSQYDWATATDTGKRLVKDRWAYTLKNMVEMGWLSEAERAKQEFPVPDKPKPRSEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z871</accession>
    <name>A0A7K2Z871_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000200">
        <property type="protein sequence ID" value="MYW28546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="51" mass="5401" checksum="192B4EC11FC2A9E3" modified="2021-04-07" version="1">VRDRRVHLVGYGPSASTIGANRAGRTAVRSVLRLLEETGGPDRTREAAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8E1</accession>
    <name>A0A7K2Z8E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_04940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000216">
        <property type="protein sequence ID" value="MYW28630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="11"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="367" mass="37560" checksum="6DDE29396103D680" modified="2021-04-07" version="1">MVRAAVLPAVGAPLEITDIVLPEPGPGQVRIALAAAGVCHSDLSLSDGTMRVPVPAVLGHEGAGTVLEVGEGVTHVAPGDGVVLNWAPSCGSCFHCGIGEVWLCADALKGTANLHARTADGTDLHPGLNVAAFAEETVVAANCVLPAPDGIPLTDAALLGCAVLTGYGAIHHSAKVREGESVVVFGIGGVGLAVLQAARIAGASRIIAVDVSPAKEELARQAGATDYVIASATTPREIRKLTGGQGTDVAVECVGRPATIRAAWESTRRGGRTTVVGIGGKDQEVTFNALEIFHWGRSLTGCVYGNSDPARDLPALADHIRAGRFDLSMMVTERITLDAIPAAFDNMIAGKGGRALVVFQSAAAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8L7</accession>
    <name>A0A7K2Z8L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol mannoside acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000246">
        <property type="protein sequence ID" value="MYW28699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="32983" checksum="AA100F6969367603" modified="2021-04-07" version="1">MSALKGRITDGLYGLGWGAVKKLPEPAAAALFRTIADRTWKRRGKSVLRLESNLARVVPDAGPERLAELSKAGMRSYMRYWMESFRLPTWTPERIKASIDVKDVHHLTEGLEAGNGVIIALPHLGNWDLAGAWVTTDLKVPFTTVAERLEPATLYDRFVAYREGLGMEVLPHSGGAAFGTLARRLRAGGLVCLVADRDLSASGAEVSFFGATARMPAGPALLAQQTGALLLPVTLWYDGTPVMGARVHPAIEVPEEGTRAEKTAAMTQGLADAFAGGIAEHPEDWHMLQRLWLDDLEPREEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8P1</accession>
    <name>A0A7K2Z8P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_05410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000247">
        <property type="protein sequence ID" value="MYW28720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514882.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000247.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029588766" evidence="2">
        <location>
            <begin position="31"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="84"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="361" mass="37852" checksum="6B114F99AEB8F929" modified="2021-04-07" version="1">MMIQRRPRTLAVACLLAATATLAAAGCAKSETSNTAGGDSSQGAQEAKSPDSTSGSGCSLETYGAPKLDLKNAVVGFSQSEKEANPFRIAETQSIKDEAKKIGVKKLLTTNAQSQLSKQISDIQDMLSQGAQFLIVAPLNSDGLEPALKAAAAKKVPVLTIDRKVNSTACKDYVAFLGSDFVEQGKRAADAMIKVTGGKGKVAILLGASGNNVTTDRTKGFVDQVKAEAPGLEIVAQQTGEFARDKGQQVMEQLIQSKPDITAVYAENDEMGLGALTAIKAAGKKPGKDVKIVSVDGTRNAVQALVNGEYNAVIESNPRFGPLAFATAQKFYAGEEIPENVIITDREYDEANAKDSLGGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z996</accession>
    <name>A0A7K2Z996_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_06350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000295">
        <property type="protein sequence ID" value="MYW28902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="69"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="337" mass="34966" checksum="ADFE86EFC7CDAA87" modified="2021-04-07" version="1">MARRIAAGAAYGGGSIGLIGAAAVGVFLAEVQLAKRQVGGGTAPVPPSADGRYGVAFAGPNDPLRLGMLGDSTAAGQGVRRAGQTPGALLASGLAAVSERPVDLRNVALPGARSDDLERQVSLLLADPARTPDVCVIMIGANDVTHRMPATQSVRCLTTAVRRLRTAGAEVVVGTCPDLGTIEPVYQPLRWLARRVSRQLAAAQTIGSVEQGGRTVSLGDLLGPEFAANPRELFGPDNYHPSAEGYATAAMAVLPTLCAVLGLWPESDRLDGSRREDILPVAKAASQAAREAGTEVTGARAPWALLKHRRRRRLPASTETEPATAPHPHPDAAHGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9M5</accession>
    <name>A0A7K2Z9M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integration host factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000314">
        <property type="protein sequence ID" value="MYW29028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003956414.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000314.1"/>
    </dbReference>
    <dbReference type="GeneID" id="61473091"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="11505" checksum="22B78D352455FE2C" modified="2021-04-07" version="1">MALPPLTPEQRAAALEKAAAARRERAEVKNRLKHSGASLHEVIKQGQENDVIGKMKVSALLESLPGVGKVRAKQIMERLGISESRRVRGLGSNQIASLEREFGGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9P0</accession>
    <name>A0A7K2Z9P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000326">
        <property type="protein sequence ID" value="MYW29076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514627.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000326.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029584445" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="9051" checksum="538C6D657E4A3AC7" modified="2021-04-07" version="1">MKYAKTAALVVGSVAALGTAAPAFAVTTPTAPSFSLDSGLNQVMASAPQVVDPVVGAVAETAETVSEDGTVGKLAGQATGVAEGAAPLLGGVPLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9R7</accession>
    <name>A0A7K2Z9R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000317">
        <property type="protein sequence ID" value="MYW29042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="9874" checksum="ADBBD84E76F20083" modified="2021-04-07" version="1">VALLVMGDGSACRTLKAPGYLDERAEAFDARATEALAAADLAALDALDETLAYELKAAGRAPWQLLSGAARGAGLGGRLLYEDAPYGVGYTVAAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAB9</accession>
    <name>A0A7K2ZAB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000383">
        <property type="protein sequence ID" value="MYW29283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="340"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="527" mass="56160" checksum="2880011437DD2A11" modified="2021-04-07" version="1">MGYAHEYAAAIMHRGRVPMDPADHVPNWQDGPRKAKFYPGADSFPLPDAPYPADATLDRGLCTEGAPGEGEFDLPTLSGMLRDSYGLTGRRLGVQANTDLSALPFYPLANWSRGSASGGGLYPVGVHWVSGPSGPVPPGVHYYSTRHHAMQRLLTGDVSAEVRAALGEGAPGPATDQYLVLSIKFWQNSFKYNSFSFHAVSMDLGACLQTWRMWAAARGLAVEPALWFDEERLAVLLGADPQEEGIFAVVPLKWAGYAPGSDGSAATSAAVRRKDVERSRTVLTFDALLRMQAATSADATARPAPGALAPAAAHPLDPAATEVELPPARPLETDVRTALRDRRSSFGRFDAQQPVTGPQLASCLSAAVAGSRLGGDTGEVRLAQLYAFVGHVEGLAPGSYAYDPERRSLRRVKEGRPGEFLQKNYFLANYNLEQAGAVLVPTVRTTAVLDAVGDRGYRLVNATIGAVAQSVYTAASAVDLGCGVALGFDNISYIEELGLEGTGEAPLLIMMIGNERPAPADFRYEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAH9</accession>
    <name>A0A7K2ZAH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="272" mass="28495" checksum="DB1E50FDDFF87547" modified="2021-04-07" version="1">MTTSTQESFLRAFHAASPAVTADAFGDARAADGRSSYEILCDRVAESGRVLDLGCGDGLLLELLARTEGRHVAGVDLSPEAVSLARRRPGLGGATVLEGRAQELPFADDSFDACVSHMALMLMGDVEQVITEVVRVLSPGATLACVIGGGAVGGEAYDLFLGLLRAAIKDAPAAQRVPALGDRRTRSREGLDSLLGPAGFTPVDWETVAIDLSGAPEQVWAALSGLYDVGPLDPRTVTSLRETFLARVEALAMPDGLVPCGMKVHVVTARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB52</accession>
    <name>A0A7K2ZB52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_09935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000457">
        <property type="protein sequence ID" value="MYW29586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="263" mass="26312" checksum="50FC4E6051A086CE" modified="2021-04-07" version="1">MPDITLTTLILLCLAAAAAGWIDAVVGGGGLLLLPALLLGLPNVPAAHVLGTNKAVAIVGTSGAAITYVRRAPVQVALAVRVGLMALAGSMGGAFFAAGISSEVLRPVIMVALLGVAAFVLLRPSFGTAAAGDIGARPVTRARIVTAVVLVGGGIGFYDGLFGPGTGTFLVLALTAVLHLDLVTASATAKIVNVCTNAGALAMFAYQGTVLWQLAAVMAVFNLAGGMAGARMALSRGSGFVRAVLLTVVFSLVAKLGYDQWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBA1</accession>
    <name>A0A7K2ZBA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_09945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000457">
        <property type="protein sequence ID" value="MYW29588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241407.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000457.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029809564" evidence="3">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="18411" checksum="6673E5BE784B60D4" modified="2021-04-07" version="1">MRSPARLMTGTATAAVTVIALGLTAAPSAYAGDDFGRLEITPATAPPGAKVTVNTTACGPKGSGIGDANSLDAGDFEVRRGTHKEVLVGQFTVPHDTRPGVYEIVVSCDNGKDAVGDLKVIGGGKHDRPDHDRPSGHVRTGVGGSVEPNSTQVALGVGVIGMAAVGGLWLLRRRTESTEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBF8</accession>
    <name>A0A7K2ZBF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylate/guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000487">
        <property type="protein sequence ID" value="MYW29700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="241" mass="25167" checksum="1C4536DDF0D508D9" modified="2021-04-07" version="1" fragment="single">RAVELRPDAAGALLGLGEVRVALGRVEEGAELLRYVRDLDHAPVESAHARLALAVLDPAARPGPAATARAVLPVFEAAGDAVGRARAHLRLAQQLQQSGRHEEAERDHARALEHAVEAGAEPERAGALGAIGISLWRGPVPVPDAVERCRALLAAHGSGRPTVRVTLNCPLAVLYGLQDRADDAYACLAEAERLAGKLGFAEAKVFLPVFRATVEALLGRGAEALALLGRADAAARRMGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBK5</accession>
    <name>A0A7K2ZBK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000485">
        <property type="protein sequence ID" value="MYW29698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="103" mass="11065" checksum="68F20A5D09B3E676" modified="2021-04-07" version="1" fragment="single">LRSLRLHREHSAPSDANGQGAEAAARALRSSARRISGSLHTFRTVLDPVWADHLRTELAWLSGTLAREHAYAGRLTRLLDALHQLSGATGLPAARGAKPAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBN2</accession>
    <name>A0A7K2ZBN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_10740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000491">
        <property type="protein sequence ID" value="MYW29743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="695"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="801" mass="83474" checksum="FC74CD1115A697FD" modified="2021-04-07" version="1">MTPVSGTTDHRTGPWHDPALTPEARADALIAAMTLQEKTAQLVGVWVGASDEGGEVAPFQHDMEEAVALDDLLPHGLGQLTRPFGTAPVDPAVGALSLARTQERIAGANRFGIPALAHEECLAGFAAWGATAYPVPLSWGATFHPELVREMAAAIGRDMRSVGVHQGLAPVLDVVRDARWGRVEETIGEDPYLVGTVATAYVRGLESAGVVATLKHFAGYSASRAGRNLAPVGMGARERADIILPPFEMAVRESGVRSVMHAYTDTDGIPSAADGQLLTGLLRDTWGFAGTVVADYFGIAFLKTLHGVAGTFGEAAGAALGAGVDVELPTVKTFGGPLAEAIAEGRVPEALVDRAVRRVLVQKAQLGLLDAGWRPKPLVLDGVADGSTGADSEALRGTVRLDTEENRALARRVAEQAVVLLRNDGTLPLAAGAGAPARIALVGPNADTPTAVLGCYAFPVHVGGQHPDTPLGIELPTLREACAAQFPHSEIVTARGADIDGPETGGFGEAVDLARGADLVILALGDRAGLFGRGTSGEGCDAESLALPGVQQQLLDALLDTGTPVVVTLLAGRPYALGRAVDEAAAIVQSFFPGEEGTTAIASVLSGRTAPSGRLPVGVPRHPGSQPATYLAARLGHSSDVSSVDPTPAYGFGHGLTYTAFEWSDLVVECGRTSTEGEFTLSCTVRNTGAREGTEVVQVYLHDPVASVVQPVQRLIGYVRLGLDPGRTARVRMTVPADLASFTGREGHRIVEPGDLELRLSASSTDTRLTARVTLTGPVRTVYHTRRLHMGIATEILTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBT6</accession>
    <name>A0A7K2ZBT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgC</name>
        <name evidence="12" type="ORF">GT040_10915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000495">
        <property type="protein sequence ID" value="MYW29778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW29778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="405" mass="43955" checksum="1C3AA2B32825F2A9" modified="2021-04-07" version="1">MRAGPSVLGIVLAGGEGKRLMPLTADRAKPAVTFGGTYRLVDFVLSNLVNADITRICVLTQYKSHSLDRHVTTTWRMSSLLGNYVTPVPAQQRLGPRWYLGSADAILQSLNLVHDEQPDYIAVFGADHVYRMDARQMLERHIESGAGVTVAGIKVPRAEASAFGVITPASDGSRVERFLEKPSDPPGLPDDPTKVFASMGNYLFSTKVLVDALHQDAEDDDSVHDMGGSILPKLTERGVAHVYDFDDNHVPGETRRERGYWRDVGSLDSYYEAHMDLISEQPLFSLYNDRWPMYTHAGHQAPARFVSGGIAGESIVSPGCVIRGQVTGSVLSPGVIVEQGAVVQGSVLHHGVRVGRGAVVRNAILDKNVDVPPRATIGVNPERDRELYTVSRNGVIALGKGQVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBX2</accession>
    <name>A0A7K2ZBX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000507">
        <property type="protein sequence ID" value="MYW29843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="125"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="21934" checksum="B322A420A9A3C018" modified="2021-04-07" version="1">SGTELLTEARVERVEEGTVVLADGRTLPAGAVVVGIGARPATGWLAGSGIERGADGSVTADSALRTSLPDVYAVGDCASFPSARYGERLLIHHWDNALQGPRTAAAAILAAESGEPLPVHDPVPYFWSEQFGRFVQYAGHHAHADTLIWRGDGAEATWSVCWLKAGALVAVLAVGRPRDLAQGRKLIGSGAVLDPERVADPAVPLKSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCI5</accession>
    <name>A0A7K2ZCI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coagulation factor 5/8 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000589">
        <property type="protein sequence ID" value="MYW30081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="27131" checksum="9E2D51E9B74DF9C8" modified="2021-04-07" version="1" fragment="single">VGPYSQQQWYTRDSSVGGWTNAVWNMTFSGVQGAPASSYPNPPYTTLDTTPISREKPFLYLDGNEYKVFVPAKRVNARGVSWEGGNQQGESIPLNRFYVVKQGATAATINAALAQGLNLLFTPGVYHIDQTINVSRANTVVLGLGLATIIPDNGITAMKVADVDGVKLAGFLIDAGPVNSPTLLEVGPQGASADHSVNPTTVQDVFIRIGGAGPGKATTSLVVNSDDVIIDHTWIWRADHGEGWGWETNRADYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCK1</accession>
    <name>A0A7K2ZCK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000560">
        <property type="protein sequence ID" value="MYW30028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029566513" evidence="2">
        <location>
            <begin position="40"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="40"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16787" checksum="F269383F05D2B711" modified="2021-04-07" version="1">MSAQVHVPSLFARVGTASVLTLAVTSSMLAPGLVDDAEAATHSTKALKIAASKKGAPYKYGAAGPSRFDCSGLTVYSFKKVGKKLPRTAQQQYNKTSRISSSKRKPGDLVFFHSGRSVYHVGIYAGGGKIWHSPKSGDVVRKAKIWSKSVWYGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCX8</accession>
    <name>A0A7K2ZCX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000609">
        <property type="protein sequence ID" value="MYW30207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7245" checksum="455C0DBE7D331788" modified="2021-04-07" version="1">MAREELTRLTGNGNGTCGKDDCPNVYRTTSGSFVIQGDVSDAFAAPDGEGLVEIPEETLREAVRALGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD66</accession>
    <name>A0A7K2ZD66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CDP-glycerol glycerophosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000632">
        <property type="protein sequence ID" value="MYW30272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="23852" checksum="B6C46E9BB6C07A77" modified="2021-04-07" version="1" fragment="single">VVQTWHGTPLKRIGADLLGTPKANLAYIASLPQRSRQYSLFITPNAFTTPIMTEAFRLRCEVLEAGYPRNDVFHAPDRAERAGAVREKLGIPADKKVVLYAPTWRDDQRYGGRRFKLDNRIDVEAARRELGEDHVLLYRKHHKVLDSIPGAGQGFVHDVTYYPDIADLYLIADVLITDYSSVLFDFAHSGRPMLFFTYDLEHYRDTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDD1</accession>
    <name>A0A7K2ZDD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_13990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000659">
        <property type="protein sequence ID" value="MYW30370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029717365" description="NlpC/P60 domain-containing protein" evidence="3">
        <location>
            <begin position="40"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="228"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="36310" checksum="83625418895E70BA" modified="2021-04-07" version="1">MVSHRRPTQSGLHRGVRVTVVTAAAATAAATLTGAPASADPKDTRESAKAAVDRLYGEAEQATELYNEAGERVDRLRGEADRAQDAAARGQESINRMRNSLGAMAGAQYRTGSIDPALALLLSSDPDTYLERAAALDRAGVRQTLTLDKLRRAQRGVAQTRAEANRALTELERNRAAVTRHKRAVEAKLRQARQLLASLPAEDRASFGRVSRSGRDGAPDLSGVAPGSARAMSAVAAVRQALGKPYVWGANGPSGFDCSGLMQWAYAQAGVSLPRTSQAQRYAGRMVPLSQAQPGDLVAYRADASHIGMYVGNGQVIHAPYPGAPIRYDPVGMMPVSSVTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDL4</accession>
    <name>A0A7K2ZDL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_14425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000671">
        <property type="protein sequence ID" value="MYW30444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2154" evidence="3">
        <location>
            <begin position="124"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="233" mass="23628" checksum="26C686C7E1F7E88F" modified="2021-04-07" version="1">KVRAGRPSADAPFRPPAPAPAAPGPRSIGGLVFLTALVAGGLGTGLSWEQQPLGTALQIGLVAALAVFGMGLLVSSALGRTGFGTVLLATVTAALLAGATMLPKEISTDWVRQEWRPAGVAAVQQGYELGSGDARLDLSGVVVPPGGTVRTRLEVGAGRAAVVVPAGVTVKVRAEVGLGEIRLEEGQRVQVRINSDQTSQRTLPPPQGSKPAGTIELKVEVGVGQVEVSRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDM1</accession>
    <name>A0A7K2ZDM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000672">
        <property type="protein sequence ID" value="MYW30453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="19555" checksum="139EB92CF7C62FB5" modified="2021-04-07" version="1" fragment="single">MDFTPSEEQTAVQGLAARIFGDLSTHERLVAAGTGTDAGLWKELCTAGLPGAVEDIGLLGLVLLLEEQGRTTAQVPLAATCVYGLLAVDGHGTAEQRGRLLPALRDGTAVATGAFPARGGVRAVDGALYGVVPWVPWLRDATHVLVADAERGLWIVDTRAPGVTVVAVETTAPWSAGRLGLDGVRGEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE65</accession>
    <name>A0A7K2ZE65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000727">
        <property type="protein sequence ID" value="MYW30657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="12497" checksum="E87F1EB656B2FE34" modified="2021-04-07" version="1" fragment="single">MNHGPEKTPHTDPEQPDRPDGPRAPGEKSAPREPDESVPADSADSSAGPVDSSAGTLTDLFAGVRSGLGTGDGLGTAGGLGTGDGELDEVVLRRMLHGAVGDLEPSDRTLEHLQRAVPARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEJ4</accession>
    <name>A0A7K2ZEJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_16180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000759">
        <property type="protein sequence ID" value="MYW30773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="13"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="500" mass="53228" checksum="6415F43430AB30EC" modified="2021-04-07" version="1">MSALSTIHIDGTWRAAGSGATREILDPADATVLAVVAEGGVEDTDAAIAAARRAFDDGPWPHKPVAERAGLLRRVAELLQRDREEIAITESRDTGKTLEEGRVDVDDVTGAFRYFADLVMNESGGRVVDAGDPDVHSIVVHEPVGVCALIAPWNYPLLQASWKIAPALAAGNTFVLKPSEVTPLSTVHLIKLLAEAGLPDGTANLVTGAGDPVGARLSEHPDVDLVSFTGGLASGTKVAQAAAPTVKKVALELGGKNPNVVFADACATEDGFDTAVDQALNAAFFHSGQVCSAGARLIIQDSISERFVTELARRADAIRLGRGTLDGVECGPLVSAQQLAKVEAYVASAREEGAIVRAGGERPEPGDVRPEGGYFYRPTVLDGCHREMKVVREETFGPILTVETFRTEEEAITLANDTDYGLAGAVWTTDAGRARRVAGRLRHGTVWINDYHPYLPQAEWGGFGKSGTGRELGPAGLAEYRESKHIYQNLNPRPQRWFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEL9</accession>
    <name>A0A7K2ZEL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_16100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000757">
        <property type="protein sequence ID" value="MYW30758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="144"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="310" mass="32098" checksum="3F93806FFB5EAFA0" modified="2021-04-07" version="1">MEGNLKWSLVTAVAPVAWGTTYFVTREYLPESHPLYGAAFRAVPAGLLLLAVCRKLPHGSWWWKSLVLGALNMSGFFALVYVAAQRLPTSLASIIMALAPLFMMLLAWPLVGERPGWKHLTGAMTGVGGVCLMVFTAAGSVDAIGVLASVGAMAMSSYGYVLAKRWSGGVDVLAATSWQLLGGGLLLVPCAALVEGAPPALDGPALLGFGYLTVVATGIAFAAWFLGLKHLPAGTVGLLGLLNPVTGVLLGLLLAGESLSGRQVLGLVLTLCGVVLGQRAARTPAPPPEAPEPAETPDPTERPSRITPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEV7</accession>
    <name>A0A7K2ZEV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000777">
        <property type="protein sequence ID" value="MYW30883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14591" checksum="6C2BF0CE20442CBD" modified="2021-04-07" version="1" fragment="single">MSTLPARAERRCHNAVNPLHSCLFFSPDLGAELGKLGFEDPGAVYFATRAAAFGPVGAGTVAATFYNFNPALVARHVPAVWSVASPEQVLGARLRAADSTLRRLLGEEIIASDEMAEAARLALRATEACTPHARPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEV8</accession>
    <name>A0A7K2ZEV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000770">
        <property type="protein sequence ID" value="MYW30866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="15666" checksum="ADEE559329B74C38" modified="2021-04-07" version="1">QALAIAWIAYGHTRAPLPQPGDHTWWHSSGPVAAEGVRLGLFTALVTAAFYLLLPLSALAARALRRRARRGGAVSPYLLLAAVSASLSAAVCLPVVALASALSGNASVWSAGVADIPTVLRLCAAAGLLVAVALGVPWTATAPRRTIHSTIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF23</accession>
    <name>A0A7K2ZF23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S1 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_17170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000807">
        <property type="protein sequence ID" value="MYW30961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029549029" evidence="7">
        <location>
            <begin position="31"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="8">
        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="381" mass="39203" checksum="3406DAFD8E992094" modified="2021-04-07" version="1">MRHATALRTGLSALLVLGAWTAVGPSAASAAPTDSAELPASAALLSAMQRDLGLTEGQARTRLAQEKAATALELKAQRAAGSAYGGSWFDSATGKLTVAVTDAGKAGAVRAAGAQTRIVEHSAAQLDATMKRIDALSAPDGVASWRVDPATSRVVVNVVGSAQGDNDVRAFVAKARKAGPVTVERTAEAPQTFAAGTVGGDPYYTGNVRCSIGFSVHGGFVTAGHCGGTGQQVRGWDNSYIGNFQGSSFPGDDYAWVNVGSGWWTVPVVLGWGTVPDQLVRGSNEAPIGASICRSGSTTRWHCGRVLAKNETVNYSQGAVHQMTKTSVCAQGGDSGGSFISGDQAQGVTSGGWGNCSSGGETWYQPINEILNRYGLRLHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF47</accession>
    <name>A0A7K2ZF47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000787">
        <property type="protein sequence ID" value="MYW30905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029704490" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="48" mass="4973" checksum="92A62E48394DCF41" modified="2021-04-07" version="1" fragment="single">MPTPARRGALLAALGVVAFSLTFPSTAWGLESFGPWSLVALRSTLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFC1</accession>
    <name>A0A7K2ZFC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_17530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000819">
        <property type="protein sequence ID" value="MYW31032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="351" mass="37063" checksum="FF7FA1D79C33EAF6" modified="2021-04-07" version="1">MSGSTAAPEKPTELDERLVRTSPLRKLLGRPELGSVVGAAAVFLFFAIVADSFLQASSFGTVLYAASVLGIMAAPVALLMIGGEFDLSAGVLVTSSALISSMFSYQMTANVWVGVLVSLLVTLAIGAFNGFMLTRTKLPSFIITLGTFLMLTGLNLGFTKLISGTVSTKAIGDMEGFESARVLFASTLTLGGVEYKVTILWWVALVALATWILLRTRFGNWIFAVGGEADAARAVGVPVIRTKIGLYLGVAFAAWISGQHLLFSYDVVQSGEGVGNELTYIIAAVIGGCLITGGYGSAIGSAVGAFIFGMTSKGIVYAEWNPDWFKFFLGAMLLLATLLNAWVRKRAEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFH0</accession>
    <name>A0A7K2ZFH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000852">
        <property type="protein sequence ID" value="MYW31103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="9490" checksum="8C872FE219D1E1B9" modified="2021-04-07" version="1" fragment="single">RGYAYLRNLPAGSARRQLKVGVLRAEAGRRVRAVPVRSVSAPEATVNSGQELHGYDHAGFEMVLDPGRLPATGGGGGGGWLVGLVVVARGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFK5</accession>
    <name>A0A7K2ZFK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029751578" evidence="1">
        <location>
            <begin position="31"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="310" mass="31958" checksum="AF3F5CF76EF3F371" modified="2021-04-07" version="1">MRSVSNRTRIGLLAAFTAFSAVLSTGSAAAATELNGDWAPFDRCPVDAPAMLAADGITNIATCISSSSVTGSITLGKSQVPTGNSDLQLGVIQHSNGTTTLVPPPEGALTADPAQVPGGLLGLMCPSAIPFVSAICRQLTDNNLNRITATIEPAGAPRDFNMVAAFSTGEPILTLPVRIHLKNPFLGDKCYIGTTANPVLLKPQNLNAPTLSLQRFAADGTPDDEGEMGRYTFAGADQGDATFAVPGASGCGAGLLDWAVNLKTGLPSAAGKNGVKLNNTSTYFGSPYDPAGLAPNEGRKLSEFWHSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFR1</accession>
    <name>A0A7K2ZFR1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU</name>
        <name evidence="6" type="ORF">GT040_18405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="WWKE01000862">
        <property type="protein sequence ID" value="MYW31191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="301" mass="32842" checksum="0EB56D6B7F7CBEFB" modified="2021-04-07" version="1">MTQSSPSRISKAVIPAAGLGTRFLPATKATPKEMLPVVDKPAIQYVVEEAVAAGLSDVLMITGRNKRPLEDHFDRNYELESALTRKGDAERLSKVQESSDLATMHYVRQGDPRGLGHAVLCAAPHVGDQPFAVLLGDDLIDPRDPLLARMVEIQEREGGSVVALMEVDPSQVHLYGCAAADATVDSDVVRVTGLVEKPEPADAPSNLAVIGRYVLDPAIFDILRHTEPGRGGEIQLTDALQLLAADEKIGGPVHGVVFKGRRYDTGDRSDYLRAIVRLACEREDLGPEFRTWLRQYVTEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFZ3</accession>
    <name>A0A7K2ZFZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M6 family metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000876">
        <property type="protein sequence ID" value="MYW31277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029532800" evidence="1">
        <location>
            <begin position="41"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="425" mass="45273" checksum="FA7A3F6D54EC305D" modified="2021-04-07" version="1">MQQPRHRIRNHRRPAALAGATALVIAAMATASTTLPGAGRATAGPAATAEDSAVAPCRIATTMGVQMSLGMPTPPGYARSTGEVRSLNLMIDFPDAEGTEPAADRFAEFFPQTSDWFTTSSYGRLDYRPEAPVKEWLRMPMPFAEYGIERGSPFEPGYRQLVEDLVAAADPLVDFSAYDLVNVLVTPNAGPSALDTVLSVTFSGNDDAPTADGVPLANTSFVYSRQDDGSGSYAQTGYRVLPHENGHVFGLPDLYTMEGGGSVGHWDIMSEDWGANNDFLGWHKWKLGWLDNEQISCASQPGVSDHTLGPLATAGGTKLAFVPLSAQSGYAVEVRTAAGNDEAVCRPGVLIYKVSSDVDTGQGPVSVADATQDSGGCTRRPNVHAELSDAPFRPGQTFTDRANGVRISVLDEDGDGNYRVRITRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG90</accession>
    <name>A0A7K2ZG90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000906">
        <property type="protein sequence ID" value="MYW31352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="89"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="31633" checksum="D64A8042EC4C30FA" modified="2021-04-07" version="1" fragment="single">MRPTLAADQVRASLSQYLATTYALADESTRRALEGFLGDAEDGIFRGPYLRVRTPFRSVENDDWQRHLDWWPRGFTPHRHQERAWERLSTLHSPAEPTLVTTGTGSGKTESFLIPILDHCRREREAGRDGVKAILLYPMNALATDQAHRIGERLGDPKDTRLREAGVTAGLYIGDRPSQEFKQANPHIAVDRDEIRRTRPDILITNYKMLDLLLQRPEDQRLWQESPLAYVVLDEFHTYDGAQGTDVAMLLRRLGSVTGLAEPGRPLGPVCPVATSATLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGB7</accession>
    <name>A0A7K2ZGB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000911">
        <property type="protein sequence ID" value="MYW31397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043857">
        <property type="entry name" value="DUF5819"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19136">
        <property type="entry name" value="DUF5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="30606" checksum="A2D6D7C9CBD92EC6" modified="2021-04-07" version="1">MVIDRERGGMDADHDGSSGRGDSGSVHEDGRPQAVSREPAGPDAPGPEAEAPEAVPDRPGAGVGIAGLSFGYQVVAALALSLIGLLACAQVAMVFLHVAPSNTLTKQHGKTVDDWIYPEFEQNWKLFAPNPLQQNIAVHVRAEVAGADGRRTTDWISLTDGDADAIRGNLFPSHVNQNELRRGWDFYVNSHDDRNKPNGLRGDLSERYIRRIAMLRLDGVDLGGTVERIQMRSASSLISPPSWSTEKADTRPTYRELPWWSVNPDDLPAPRDAARAEEGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGG4</accession>
    <name>A0A7K2ZGG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000916">
        <property type="protein sequence ID" value="MYW31430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045993">
        <property type="entry name" value="DUF5949"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19374">
        <property type="entry name" value="DUF5949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="166" mass="17218" checksum="E7265D56507C93C7" modified="2021-04-07" version="1">MTTPQTSSGTFTPAQLGTQILIGWSSRQPDADQDTAYLLAYSLGDGQDGPEAGSNALRIALGRAGLQVGGPIQDAAEAPGIQAKLLVQAGQAVLTMPHLKAQYPAPAEWLAAALGQGQVYGMFATTPWPEAVPGQPVSEDQLRAFAANEEVVRSAAHCLLPVRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH71</accession>
    <name>A0A7K2ZH71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2752 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000992">
        <property type="protein sequence ID" value="MYW31701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="15817" checksum="2382DAEA14B0BFEA" modified="2021-04-07" version="1">MVPRTAQAGPGTPQPGSPATRVRRLATPLGILATVTAAFAYVGTVDPNEPGHYPVCPLLKITGAFCPGCGGLRSAHAFIHGDLGAAFSANAVATTGYFLFAAVWVLWLVRAWRGQPLRIVLAPVWWWSIGALLLIFTVVRNLPFGSALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHJ5</accession>
    <name>A0A7K2ZHJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_21660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001020">
        <property type="protein sequence ID" value="MYW31814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029621409" evidence="4">
        <location>
            <begin position="39"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="291"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="406" mass="43594" checksum="43694C7C1AC75DCE" modified="2021-04-07" version="1">MASHRKPRTKVRTTTPAVGFTTAALASVTLLSTQSATAAPVEPKPAIEDVQKKVDELYRQAGSATQQYNRAKAASTAQRAKVDTLLSDVAKRTEKINEARRELGAFAAEQYRTGGIAPTATFFLADDPQAYFDQSRLMSRSTERQQKAVDDFRTQQAAASKKRAEAVQSLESLTETQTTLRSSKQKVQNKLTEARSLLAKLTAEEKARLAELERKKEAEAKEKAEKLARRQAAEAKEREEREAAEKKAREEAAKESGGDSGSGSGGGTGTGTSPGSGTGTGTGSGADGSYAAKAEKVLAFARAQIGKPYVWGASGPASYDCSGLTQAAWREAGVTLPRTTWDQVKVGTRVATSDLRPGDLVFFYDDISHVGIYKGDGMMIHAPKPGANVREESIYYMPIYGSVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHJ9</accession>
    <name>A0A7K2ZHJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SHOCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001006">
        <property type="protein sequence ID" value="MYW31729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046288">
        <property type="entry name" value="DUF6325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19850">
        <property type="entry name" value="DUF6325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="17864" checksum="5D553E2BB597EFBB" modified="2021-04-07" version="1">MAVGPVEHLVIAFPGSGFTGAVVPVLADAVASGAVRAGDLAFVRRAEGGALTPVELAELDPEGTVPAGGAEGGAAVALSAGNVEVLERSVPQGEAVALVVREDLWTSQLARTFRDAGGAFVTHERFGATGSDADADEAGEGDDIITRLERLAELWGRDVLTDAEFAEQKANLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHM3</accession>
    <name>A0A7K2ZHM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001022">
        <property type="protein sequence ID" value="MYW31828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029579455" evidence="1">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="177" mass="19068" checksum="95D71ABF841C27B3" modified="2021-04-07" version="1">MRRNALRQVGCIALLAAILTGAAGCGGTEPFRISEACGTKVDPDLIGQLLPRGEELKTKDTFSEPKQPRCEFAVDGQEQVGLRGDVVEPFVKPLEVKESVMLRLGNPAPADIGGGATIADHGAMALQACTYEGEKMQYVLSIDGVEDPKDTAERRRLLEEFLRSQLPVAMEAEGCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHN7</accession>
    <name>A0A7K2ZHN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001022">
        <property type="protein sequence ID" value="MYW31835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10174" checksum="3F7A7836A48F4C97" modified="2021-04-07" version="1">MTEVAEVEVEAESGRAALGRALKFLREQAGLSLGRLAEATYDGVGMAFNGDAAAWGERADHHTVFVHVDKYGDLSRAERLAASIGSTVLGAAQRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHQ4</accession>
    <name>A0A7K2ZHQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001034">
        <property type="protein sequence ID" value="MYW31874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="380" mass="42220" checksum="6A273F6A912D8060" modified="2021-04-07" version="1">MNRLELTGLTTRPAQVWGGVRLVPLVREAPVEGLRLHREVYERLGAGIVELGPRDHYVSYIPHGLVADWSTGDPEVPRGGGQSAAYGTQLGGGRDVPRTLRLPRPPLHRMAKRRPGDRLRFLPLHLALEGYLALHFGGPSTAWEEWSRRALRDGLSPRAEDAYLGWSVRGLGDALRIFEIHPDQCGVMVYVSDALAAAFVVPHPEDYRLLHASLVEDLYGELVHQYALYGAPVPEFGARLGDGAHIRTLAGLRAAARGQQRVWGEAHESLFARELLDSSYGFDRVYRMGSFTLWRFLPPFVRDGSGQHIGETVTDHKGRVAYLKTFRLSDAQIRRGYLLHVLAGADWELPRAAATLGSSREELVRRIRAAGFAQLLKGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHS3</accession>
    <name>A0A7K2ZHS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SWIM zinc finger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001046">
        <property type="protein sequence ID" value="MYW31903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="12236" checksum="09CD6F84FA717C97" modified="2021-04-07" version="1">PDTPPPGGSTAAALAAYGEALRGDPWLDAWPVTLRDVIPVPSEGGWQLADAEGASALPLSSAALSRPGLWKLVALSGGGPVTVFGELGHRGFDPFAAWDTGGTGGGDGSGSGSAEVTDGAVRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHW6</accession>
    <name>A0A7K2ZHW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001051">
        <property type="protein sequence ID" value="MYW31908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="14961" checksum="54994816EAF510E4" modified="2021-04-07" version="1">AAGVTVVLADQFDTLETLTETVRTHTRARVVLGPASREQITAVLGDGPSTTPPPEVPAGRGYARLGAGPVLRLQVPATPDPYDDATSEAHRQAVLDALPERPDAAPRQESQPKPPGAPDGPVEVPVAVEAAPTGQLAKAQAAIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIA1</accession>
    <name>A0A7K2ZIA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001076">
        <property type="protein sequence ID" value="MYW32067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="177" mass="19827" checksum="603D1290884439EF" modified="2021-04-07" version="1">MSEANGRGREETEDERADRQWTELLQELRVAQTGVQILFGFLLAVVFQPRFGDLSEVDRDIYVVTVVLGSATVAALIGPVTYHRLLTGRRMKPETVIWASRMTVLGLVLLFLTMCSTLLLIMRVALHNTFALWLVGGIALWFLACWFIFPLWALARGRSGVREDDPFTTGPSAGKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIB6</accession>
    <name>A0A7K2ZIB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001085">
        <property type="protein sequence ID" value="MYW32096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="135"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="380" mass="40080" checksum="1643D2AD974477C1" modified="2021-04-07" version="1">MVARSAGTRRFVRLLPVLLIGGGLLFDSLAPPNFTAVPLFVAAPLIAAPFFSLASTIRTGVAAVLSVIAMRLSDGTSTQVVPVIEMITVLTAAALALVINGVVRRSNEQLASARVIAETAMRAVLPTPAERIGGLQVAARYEAAQADEFVGGDLFAVADTPYGVRLVVGDVRGKGLDAVEAVAVIIGAFREAAEQERSLEGVAQRLERALAREGTRRYGLDAMEGFITAVLAEIPPGSALLRLVNRGHPEPILLHADGALEVLAPSVPAMPLGMDLGVWPDRSDEWEMPAGSTLLAFTDGLSEARDANGTFYDPAARLRGRIFPGPEELLSALTDDVRLHTGGRSTDDMALLAVSRPAEGQAPRRTTVKIVGRGDDTVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZII3</accession>
    <name>A0A7K2ZII3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="736" mass="83426" checksum="08F1D9A1D1E672AD" modified="2021-04-07" version="1">MNRQRLSLALKTLEAGDWLTFEQFAADFLAVDYPSLRTMAATKGDKGRDGQLFTPEEDPTDMVQYSVTRDWKSKINQTLKRLAENFDNVRRLIYATNQEIGPSADDLVNSIMREKGVIVDVRDANWFIERRETHPQRASASEDLCRKIVDPLLRKDNISSQVGLALSDQEARLGLLHLSLQSRDEATERGLTRESFESLTLSALHDTSPENLLTRGEIHERVRSFLPAGHEQQVGAQVDGSLLRLSGKKGRVKHHKGSDKFCLAHEERKRLIERTAEFMQGERSLEEQLVAAVDFYGGGLNSAQRATVGSELRASLELLLLKRGEEFAEAVRTGEMGHADKEGVEQLLRDESEKKSYNIHPKIVADALVHVLDKPTDEVKPHLRRLADGYTLFSFLRQTPDVQKVVVSIFSEGDFWVDTSVILPLIAETLLEDSSQRNYTTLFKAASDAGIKLFVTDGIIEEVERHLNRCLQFSRTEVQKWNGSVPFLYAAYALSGRARSGFTEWLENFRGSSRPVEDVRLYLEEEISIYRKNLVEEADSASIELRAAVQEVWNEAHERRRNPKEADWDPAITRRLVSHDVETSVGIIQLRSRSASSPMGHRYWLVTLDKVAFRLKRELSSRLHDAPASPVLSPDFLSQFLRLGPLRTAVEKEQRINLPLMVDVSKYDYLPKSLVELADSLREKLGGKSERLIRRGIRDSLDKMRSEEGVEAAGGWQAAEERIMALLQEEGSLQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZII9</accession>
    <name>A0A7K2ZII9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="477" mass="52211" checksum="D4A9D3A0EAF26510" modified="2021-04-07" version="1">MGQQPNVLTPEQSPLHRFGYTLRELRKVRGMSLRELAAKSFMSHSKLQKWENASRPPKDRAEVELIDSLLRAGGVLVDLWERINPGVSARAAVSVSAPHVSEASIGLATAGIERAASDHEGIFVPARLRDGSVVFVALDRRDLLRGGVGIGAAAAFGAGTPAVADSEVVQGLKQPPRMAAAYSGTPIEHFRQARRLLIDNDNLLGPRHAIAAVREHIEKIKSLRQDTKGADRHDLMELQTQYAEFASWLYQDMGDFGSAEFWLDRAFQWSHTVGDGDLTSYVMARKAQLAGEMRDLVDVVDLAEAAQRMARPRSRLAAVARTYESYGHALRGESSDSERAIDDVRNSLDRVSSDATPWGVWLNEQYLDVHRAQGLEVLGKHAQAAEVFTRAIEALPAGYHRDRGVYLARAAVAHAGAGSPEEAAAVGLQALAVARDTGSGRIMRELVNLDKTLVPWQRQPEVSAFRENFDAVLAHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIS4</accession>
    <name>A0A7K2ZIS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">GT040_23565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="84" mass="9558" checksum="3CBED006E9C70CB6" modified="2021-04-07" version="1">MDWRHNAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQCLQWALESGQDDGVWGGLSEDERRAMKRRAARNRARSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ77</accession>
    <name>A0A7K2ZJ77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3367 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001158">
        <property type="protein sequence ID" value="MYW32397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021798">
        <property type="entry name" value="AftD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11847">
        <property type="entry name" value="DUF3367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1246"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1289"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1328"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1358"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1443" mass="151547" checksum="49234D4289246C7C" modified="2021-04-07" version="1" fragment="single">MFMTSAVHLPPHQSPDDGDPLPGRPVVEPAAPRSRRWLLGFWATVFVAFLAVSPGRMTFDTKLGVVVDPGRFLGDLGELWHSRSGFGGITDQYVGYLVPMLPYYGLADLLRVPTWLAERLWLSLIVAAAFWGALRLAERLRVGSSATRLLGALVYALWPTYTIVVGSTSAAALPGALLPWVLLPLTDARLAPRIAAARSALLIPLMGGVNAASTLASLLPVGLYLLSRPGGPRKRALLLWWIPGVILATAWWIVPLLLLGTFGENFMPYVESSYTTTTTMSATEVLRGAGNWVGYLNFGEPWLPAGWTVATAAVTILGSALAAALGLAGLARRDLPERRWLVLTVLSVALVTLAGYGGALGGLFHGTVQEWLDTWLVPFRNIYKFQTGLALALALGLAHIAAVASLRAGRDERVPVRARRLAPVIAAVLVLPGLAWPYVNGSILQPGSFKEIPDHWSKAAGWLKENSANDRALVVPATAHGIYTWGSTIDQPLDVLADTPYAQRDYVPFGTPGNRRAMDAVEQALTSGGQVPGLSEYLNRAGLHYVVVRNDLDPDQLGYVPTTTVKRTLEASGYKRVTGFGPVMTGGRIADDTPVQIEGLYPRQEAVEIYEPPTGTGRPGRASIAPVSSTAVVSGGPESLLPLSANGALDGRPTVLAGDAHPGVGKPSLYAAGDGLRRADTRFGLVNTNTSHTYTADERNAPESEQDPGAAPRQILPTEGKEHQTTAVLRGAKSVSASSIGNWLFHLPQYDPVNAFDGNPDTAWAEGSAASPEDEWVRIDFSGTQEIPGSLQLTPLPSNGVRAAATEVRVETDSGSKDSPIRPDGSPQEVAAPAGPASWLKVTILKSQQGRPGLTGAGFTDIAIPGVQVTRMLELPSDAPREGADSTVFSLKRGSDPGGLSAVAAETGLHRQFTAGQAGAYKVAASAVPVPGEALDKLLFDLTGKRDKILVSADSTARLGTNLSARNLTDGDLTTAWIAGDRPVLHLSWPEKTQIGEIVFAAAGGISTRPEQVQISSPDGTAVAAVDENGMARFSPITTDKMDITISRQAPLTVHNPFAGGQLQLPVGLSEVYIPALDKFRSPQPAPEKKFSLPCGQGPVLSIGGTLMETKAEGRIRDLTQRRPIAVSLCSERSEVDLGASTHTVEAGDAGPLAITDVTLSTGETKAPQATARTVDVKKSDGDRRTLTVGAGDASYLQLHENYNKGWKATLDGKELTPLRTDGWQQAWLVPEGEGGTVTLEYEPSLIYRAGLIGAGVLFLVLVGLAVFRRKGSGPAENAYEREEQALPPAPGLILGTVALTLVGIVIAGPVALVVPVLAVLAHFRPSLLSPVAFAAMAGAGVIVALSTGEYTAVGEGAFGAAPQLLALIALFAALVTVGSAPSRGRRRAGRSTEPSAVTADGGDGDATIPQQQVGPPSGRTLSADAKRPRTDPPASGPGGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJH3</accession>
    <name>A0A7K2ZJH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001188">
        <property type="protein sequence ID" value="MYW32481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13491" checksum="63CCA11D48AB58C3" modified="2021-04-07" version="1" fragment="single">DVWVYLPPDAVPYRPAYEPGEQGRLPLLVLCDGDMWFDRLGLQDTLDALIADGVLPPLAVLAPDAVGTATRRLELGGRESYVSFLADEVVPWASARWPLTARPDRTVVAGQGLGGMTALYAGLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJI3</accession>
    <name>A0A7K2ZJI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001195">
        <property type="protein sequence ID" value="MYW32503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="30608" checksum="720CFBD53009180A" modified="2021-04-07" version="1" fragment="single">MADTRLIQSRYRLLDLIGRGGMGEVWRARDESLGRLVAVKCLKPMVPQHDQASTRVLRERFRREARVAASLQHRGVTVVHDFGEHDGVLYLVMELLEGHNLSQLLEENQQRPLPVDHVVDIAEQVADALGYTHRQGIVHRDLKPANIMRLTDGTVKICDFGIARLGHDINVTSRLTTTGIAMGTPHYMSPEQIGGKEVDHRSDLYSLGCVLYEIATGVPPFDLDDAWAVLVGHRDTQPEPLRTHRAELPGFFDRVVLDLLAKAPDERPADAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJJ7</accession>
    <name>A0A7K2ZJJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS transporter subunit EIIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GT040_25405</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001196">
        <property type="protein sequence ID" value="MYW32515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="126"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="479"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW32515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="518" mass="52943" checksum="2DEB754EAA2E8AF9" modified="2021-04-07" version="1">MVTEDKNRATAAAILPLVGGAANVSSIAHCMTRLRLGLHDRSLVDDEALKALPAVMGVVEDDTYQIVLGPGTVARVTPEFEQLVEEGREAAPPQAAVSSDDLAAQGAAIKAQQKAKNATPFKLFLRKIANIFVPLIPALIGCGIIAGLNGLLVNLGWLPAVTPALAAMASGFMALIAVFVGYNTAKEFGGTPILGGAVAAIIVFPGVANIDAFGQTLSPGQGGVLGALGAAVLAVYVEKWCRRWVPEALDVLVTPTLTVLISGLATIFGLMYVAGEISSAIGTFADWLLSNGGAGAGFVLGGLFLPLVMLGLHQALIPIHTTLIEQQGYTVLLPILAMAGAGQVGAAMAVYFRLPRNESIRRTIKSALPAGLLGVGEPLIYGVSLPLGRPFITACVGGAFGGGFVGLFNQLGDTVGSTAIGPSGWALFPLLDGNHGLGSTIAIYGAGLLVGYVAGFLATYFFGFSKDLLTEFNVSQDPAPSTVAATGGPHPTPDTDTARSNGPGSTDPGSPEKAPVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJL0</accession>
    <name>A0A7K2ZJL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7772" checksum="D46DB5B775C137BA" modified="2021-04-07" version="1" fragment="single">MRFGFTEEQQQFRADVRRALRAPEVRAAVAEATPAHGVEPDMRPLYRLLGERGLLAVHWPAEFGGADRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJM9</accession>
    <name>A0A7K2ZJM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001198">
        <property type="protein sequence ID" value="MYW32556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043763">
        <property type="entry name" value="DUF5709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18970">
        <property type="entry name" value="DUF5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5709" evidence="2">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="16570" checksum="FF279228DA91FEB6" modified="2021-04-07" version="1">MSDEARGDDVYQPQNDDGQDPPNDELDLENTLGERDLDDQMEEGYSPPERPLGVDKFGTTGEEEQEGESLDQRLAQEVPDVRPPDGDGIGDVAGGEGEPEERIDGDARAGRLTAADDATGRNTDVFAEDVGIDGGAASAEEAAVHLADEEDGGGREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK18</accession>
    <name>A0A7K2ZK18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001222">
        <property type="protein sequence ID" value="MYW32683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="10015" checksum="89D939B5744E73B5" modified="2021-04-07" version="1">SGKRPGATNGRPGTRPGARTTSAGRRPANPKLLRQRLVVFVVVTLLVALGIAAAQGCQGPARGMGGSEQPSRPSAVSQEQHVHVLEQVRMRAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKA6</accession>
    <name>A0A7K2ZKA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">GT040_26750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001250">
        <property type="protein sequence ID" value="MYW32773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW32773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="12220" checksum="897715F5E794BAC7" modified="2021-04-07" version="1">MADFSRLPGPNADLWDWQLLAACRGVDSSLFFHPEGERGAARSARETSAKEVCMRCPVRAECAAHALAVREPYGVWGGLTEDEREELMGRARTRLITAAPSGATTATTGTRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKG2</accession>
    <name>A0A7K2ZKG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001261">
        <property type="protein sequence ID" value="MYW32842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512835.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001261.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6485" checksum="2DEDB163EADCF9AF" modified="2021-04-07" version="1">MSNGAKVAVAGVVAGVALWALLGFWWALLVVIGVPVAGYLLLDPSQRSRLRRINRKQIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLF8</accession>
    <name>A0A7K2ZLF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001349">
        <property type="protein sequence ID" value="MYW33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029515228" evidence="2">
        <location>
            <begin position="30"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="391" mass="40422" checksum="45552FED861B1C36" modified="2021-04-07" version="1">MRSPRRFRCAALAALTAGALFAVAGCDSAADRTTKGTTGTAEAEDVLLQPLAEPGPGPFTKPTGRQTPSPSATPSPQEGDGSATRTVHRVSGAVPGLYGGVRSEASCDVEQQARLLTADQDKARAFAEKAGIEAVQIPGYLRSLTPVTLRADTQVTNHGYSAGSVTAFQAVLQAGTAVLVDGKGLPRVRCACGNPLERPVIAKGQVTHRGERWAGYDPARILAVDPGVKPLSSLVIVDTADNTWIERAVGDDVGRDRTPDDPPPFEPSVDLLFPSPARPSDPAPTESGPSAPSPAEPEGTECPDSPGDPAELPPGCLPPMEPDPGTETPDDFDGMPSDEPWEMEEGEPGVVPEPTQVSPGELDGLEESDGSGELDGFGEPADSGVPEPFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLK0</accession>
    <name>A0A7K2ZLK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001354">
        <property type="protein sequence ID" value="MYW33222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="856"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="912"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1054" mass="108908" checksum="7C1057AF0A48021D" modified="2021-04-07" version="1">MSWLSRFSLAQRALIGLISIVALVFGAIAIPQLKQQLLPTIELPMVSVLAPYQGASPDVVEKQVVEPLENSLKAVDGVEGITSTASEGNALIMATFDFGDEGTKQLVADIQQAVNRARAQLPPTVDPQVIAGSTDDIPTVVLAVTSDKDQQALADQLDRTVVPALQDIEGVGQVTVDGVQELQVSVVPDDKKLAAAGLNAGALAQALQAGGATLPAGSFSEAGKNRTIQVGGGYTSLKQIEDLQIAPQPQAGGGDGGGQAKLVVRLGDVAEVKQEPSTAVSITRTNGKPSLAVMATMDKDGSAVAISDAVKDKLPDLRKDLGAGAELTVVSDQGPAVSKSISGLTTEGALGLVFAVLVILVFLASIRSTLVTAVSIPLSVVLALIVLWTRDLSLNMLTLGALTIAIGRVVDDSIVVLENIKRHLGYGEERHAAIITAVKEVAGAVTSATLTTVAVFLPIGLVGGMVGQLFGSFSLTVTAALLASLLVSLTVVPVLSYWFLRAPKGTPEDAAEARRLAEEKEAASKLQRLYVPILRFATRRRITSLVIAVAVLIATFGMLPLLKTNFFDAGEQEVLTVKQELAPGTSLQAADEAARKVEKVLTDDKGVKDYQVTVGSSGFMAAFGGGTGSNQASYQVTLKDASDGEAAQDRISEALGKLDSIGDTTIAAGDGFGSQDLSVVVKASDADVLKKAAEAVRTEVATIKDVTDVQSDLAQSVPRISVTANEKAAAAGFDSTTLGGIVAGAVRGTPAGSAMLDDTERDIVIRSARPTATMAELKALPLGPVKLGDIATVELVPGPVSMTRIDGQRAATITAKPVGDNTGAVSTTLASKIDALDLPEGATATIGGVTEDQNEAFAQLGLAMLAAIAIVFMLLVATFRSLVQPLILLVSVPFAATGAIGLLLITGTPLGVPAMIGMLMLIGIVVTNAIVLIDLINQYRSRGLGIVEAVIEGGRHRFRPILMTALATIFALLPMALGVTGEGGFISQPLGVVVIGGLISSTVLTLVLVPTLYAMVELRKERRAKKKAAKRAAKTGVPAQPEPEEAKEAEPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLL7</accession>
    <name>A0A7K2ZLL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001357">
        <property type="protein sequence ID" value="MYW33241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="190" mass="20885" checksum="59E83127A15B0AE0" modified="2021-04-07" version="1">MRHSPTPPLPPPPPGTTIRDMRIEDCEAVATIRVRGWQYAYRGLLPQPYLDGMDIAEETGLRRRYFEERGEAVNVVAERPDGLVTGWACTGPHRAEGRPLPGCELYAIYVLPDHIGTGTGRALLAELAARAATAGHPEMALWVLRENAAARRFYERAGFRPDGAEDRFRAGGVLVTEVRYARPLTPPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLS1</accession>
    <name>A0A7K2ZLS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001369">
        <property type="protein sequence ID" value="MYW33305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11673" checksum="8A4A19E6E451558D" modified="2021-04-07" version="1">MFSEAELLAVFRALSNPARRQMLVWLKEPMSFPGQKPDDVAIGVCVTDIQHRTGLGQSTTSQYLAMLRQAGLVVATRRGRWTYYRRDETNIARLLDTLRDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLZ3</accession>
    <name>A0A7K2ZLZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_29990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001387">
        <property type="protein sequence ID" value="MYW33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="30208" checksum="AE0083A5678BB24D" modified="2021-04-07" version="1">MKAARRSRPRYWRGAVLAVAGLYFVTPLLSSFVFTVHVPNQGLTFEAYSGILSADGFTESLFLSLSLAAATIALALLLVVPALVAVRLGPPRLRAVVEIVCMLPLVVPPIALVTGIATVLRWGPDHFSRTPLYQTFLAVQNESFPVVLVLAYTVLALPFVHRSLDAGLRAVDVPTLVEAARNCGASRLQVIVSVILPNLRSSLAGASFLTLALVLGEYTVASLLGFRPFAVWIVTVSGAEARMSVAVSLLSLLITWALLLVLSRAGTGSSATTVPAAAPTPVPGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMK9</accession>
    <name>A0A7K2ZMK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001411">
        <property type="protein sequence ID" value="MYW33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="10"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="21911" checksum="6B179FE9FD8BD825" modified="2021-04-07" version="1">MRGTIEGFTHGPVIPALAFLAACVGAALGLRCGIRSLRTHRSFKTGRLALGALSIGCGIWTMHYVAMTGFTVVEAPLSHNKPYTLAALAVAVVMAGVGLFIVGYRGATRMALITGGTLTGLGIASTHYLGMAGIRFRGHFTYETPLVVLSVLIAATAATAALRAALSARILLSGLGAGVMMAVAVTGMHYTGMAALGVHLHPTAPGPTSGHVSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMP8</accession>
    <name>A0A7K2ZMP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001432">
        <property type="protein sequence ID" value="MYW33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15482" checksum="4B0350CAF133A70E" modified="2021-04-07" version="1" fragment="single">MSVSKALVAVCAHLLIERGVLDPDDPVARHWPEFAAAGKAQTTVADLLAHRVGLPAYTDDPAGLPDPLLLDPAARVRALAAASPVWEPGKAFLYHALTYGDLVGEVVRRVSGESVGRFFAREVAGPLGLDLWIGLPEREEHRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN26</accession>
    <name>A0A7K2ZN26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561019.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001443.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="36170" checksum="05483C421B7456D8" modified="2021-04-07" version="1">MRIFGKVRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLEPWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRESGAPDWWNVGIAATALQDWPLARRAWQAYGLKVPGSGLNSAATTEPTGMELGSAAVRLSPEGEAEVVWGRRLDPARMEVLSIPLPSSGRRWGEVVLHDGVPNGERVTAAGPSYPVFDEIELWAPSPVPTWVVLLEAATEEDRDALEKLASDAGFAAEDWSSSVRLLCRACSESRMESDEGDGEHLDPHDHSEPGHPGPLGHRTAGAGDLWVPERECGLAAPAGLVRGLLDGWVADSPDSREWRDLEEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNE3</accession>
    <name>A0A7K2ZNE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001486">
        <property type="protein sequence ID" value="MYW33852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="30212" checksum="202DA8C56C81A73B" modified="2021-04-07" version="1">MSAIAAAATTSTGEAVQFWILGTVAVIGAFSTILLKKSVHSALSLAGTMVVLAVFYLANGAYFLGIVQIIVYTGAIMMLFLFVVMLVGVTAADSLKETLKGQRWLAVACGLGFGILLIGGIGNASLSTFNGLGAANALHGGNVEGLANLIFTKYVFAFEITGALLITATVGAMVLTHRERTERAKTQREMSEERVRGKHLPPLPAPGVYARHNAVDIAGLLPDGTPSELTVMKTLRDRGQIRDVSQEALADLKALEQRSGERLGREDADAVARGSNPASAAENSEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNE4</accession>
    <name>A0A7K2ZNE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_32585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001490">
        <property type="protein sequence ID" value="MYW33881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="207"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="320" mass="33841" checksum="1CAF2EF8DAF335E0" modified="2021-04-07" version="1">MDVFDELLRGVRGKGAVFGRSVLWPPYSLRFTDGAYLTLCLPMRGAGWLVPEGGEPLRLAAGAAAIVRGPAPFTFTDDPAGGTGAGVREVRWGADPAPAPELAAVPGPGAELDGPTVLLAAAYDVQAQVPQRLLRALPPALVVPDEEDCGPLRDYLAAQIGGARPGYQIVLDRLLDWLLVCTLRDWFDRPEAEPPGWYGALADEVAGPALRAMHEDPAHPWTTAELAARAGVSRTTLAKRFTELVGDGPVAYLTEWRMAIAADLLTRPELTVAAVARRVGYADAFGFSAAFKRLRGESPSAFRREATAGGRAPGQAAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNJ8</accession>
    <name>A0A7K2ZNJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001501">
        <property type="protein sequence ID" value="MYW33941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="14266" checksum="E44E6B08D6981846" modified="2021-04-07" version="1">MTLQDFARSEYVSLTTYRKDGTPVATPVWAAAEGEVLYVWTRSDSWKVKRLRNNTDVVVTVCDVRGRIAEGAPKAEGTARLLDAEETRAVRKLLARKYTWKFWLVDRPATIARLGKRPHTGIAVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNM6</accession>
    <name>A0A7K2ZNM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001506">
        <property type="protein sequence ID" value="MYW33971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="31"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="268" mass="28050" checksum="1DCA571C32EDED1C" modified="2021-04-07" version="1">MPTPKKSTSGSKKPLAYGAVIVAAAGLLGFASYKATAPDNSSANTSTTPAAEVSADPQAGVYPELAKLARRDAGDKLAVGRADAPVVLIEYADFKCGYCGKFARDTEPELIKEYVEDGTLRIEWRNFPIFGEESENAARAAWAAGQQDRFWEFHAAAYAEGAKEKGFAEDRVKALAQEAGVKDLARFMKDLDGEAARAAVAKDQEQAYGIGATSTPSFLINGRPIAGAQPKETFTQAIETAAEQAKTTGKAGAGTTEGAAEGSGDSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNQ3</accession>
    <name>A0A7K2ZNQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001508">
        <property type="protein sequence ID" value="MYW33983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="16911" checksum="9192FC6E0A4761B4" modified="2021-04-07" version="1">KENDSAAARPSPTATATASKEPDATGSEAPTDAGEAPVDEVPKAFVGTWEGPLTEQTSGQPHGTLTAAFTEGRKGTQVVRMSTTISQLGITVTCNSVGTLTSGTAKELKVRERTDPDRPSTPGLCTTTEADLVFRLAADGTLGYRSKERAAGLPYGDLTRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNZ9</accession>
    <name>A0A7K2ZNZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001519">
        <property type="protein sequence ID" value="MYW34008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9185" checksum="608CB685A2FF9F18" modified="2021-04-07" version="1" fragment="single">MEEIFRDALHRTADALLPLPDLVPDAVREGERRRVRSRGLAVAGTFVAVTAVTLGLALLGPLLRQTPDTEPAAPAPGPSITRPTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP21</accession>
    <name>A0A7K2ZP21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_33625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001541">
        <property type="protein sequence ID" value="MYW34080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="258"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="408" mass="44223" checksum="80A931DD3838C6A6" modified="2021-04-07" version="1">MAEFTLDLNDDQKQVRDWLHGFAADVIRPAASEWDEREETPWPVIQEAAKVGIYSLDFYAQQFFDPTGLGIPMAMEELFWGDAGIALSIVGTGLAAVGVLANGTEEQIGTWIPQMYGDANDVKVAAFCSSEPDAGSDVAAMRTRAVYDEARDEWVLNGTKTWATNGGIANVHVVVAVVDADLGSKGHASFIVPPATPGLSQGQKFKKHGIRASHTAEVVLEDVRVPGHCLLGGKEKLDERLARARERAKSGGERVKNAAMATFEASRPAVGAMAVGTARAAYEVALDYARTRSQFGRPIIDNQGIAFQLADMRTQIDAARLLVWRASWMATTGKPFTSAEGSMSKLYASETAKKVTAQAIQILGGNGFTREYPVERMHRDAAIYTIFEGTSEIQRLVIARTLSGMPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP27</accession>
    <name>A0A7K2ZP27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation:dicarboxylase symporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_33830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001546">
        <property type="protein sequence ID" value="MYW34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="455" mass="47196" checksum="7ADABFC8952FB0B1" modified="2021-04-07" version="1">MAVAAKQRDRTHYLYIAVIAAVALGILVGFVAPGVAVELKPIGAGFVNLIKMMISPIIFCTIVLGVGSVRKAAKVGAVGGLALGYFLVMSTVALAIGLLVGNFLEPGSTLHITEAARAAGEKQASGASESTVDFLLGIIPTTIVSAFTAGEVLQTLLVALLAGFALQAMGSAGEPIIRGITHIQRLVFRILAMIMWAAPVGAFGAIAAVVGETGLDALKSLAIIMIGFYVTCGLFVFVVLGAILRLVAGVNLFSLLKYLGREFLLILSTSSSESALPRLIAKMEHLGVSKPVVGITVPTGYSFNLDGTAIYLTMSSLFIANAMGDPLSASEQISLLIFMVIASKGAAGVTGAGLATLAGGLQSHRPELVDGVGLIVGIDRFMSEARALTNFAGNAVATVLVGHWTKEIDKERVGQVLAGQFPFDERTLVDDDHGGPADSTDVPEQRETAPEHAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ55</accession>
    <name>A0A7K2ZQ55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_35545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001624">
        <property type="protein sequence ID" value="MYW34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="488"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1438" mass="155391" checksum="E6A33672A121A7D4" modified="2021-04-07" version="1">MALTYEELNARANVLARRLRAHGVGTESLVVVCLPRSVELLVSFLAVMKAGGAYVPLSPGDPDQRRRHIVEDARPTLVITDADHQGDEEFAGSTALCVDGLPAWVEAAGPAERSDLDHEVRPEQLAYVIYTSGSSGRPKGVMCPHHGVANYLDWAVETYTTLGTDGAPLFSSVGFDMVVPNIYAPLWCGQPVRLVPDDQDLPAQISEVVSSGPYGFIKLTPGQLDLISSTTGADGARSLAGLLAVGADLFPTQSLQRWRALDTSTPVLNEYGPTEASVANAFFMIPDDFSGKTIPIGRPIENTSMYILDEEFQPVTAGAEGEIFIGGVCCARGYLGRPDLSSAKFVPDPYSPDPGARMYRTGDRATWDDQGNAVFLGRSDRQLKIRGYRVEPGETEAALRRHPGIHDAAVVGHRGDPDAPLVLKAYLVVDEGVPEGLVAWLKERVPDYAVPRQYATVDAIPLDANGKADRSALDRQNPGPERAADGPAAGSSVEDVLREAWKSVLGVTTVDPDANFFELGGDSISTVRVASKLREQGYELSLTDVFRSPTLHALASLVVRSDAVAETAPEVGGPLALTPIQQWFIDRELVDRDHNNQSILLEWKDEPEVLALETALEALVNAHDALRLSFSRSDGGWRQEAGEAPPGFELLSEVHLDDDADVDQQLQEAATAVQRSLDIEGGQVLRAALITSAERPSLLLIAVHHLAVDTFSWPTIVRDLDIAYTNLVAGREAGLSEDSFVFSKWASALAAVRPREAAPSEDRAGTAPEPVSLPRDMADGANTVGGAACVEVRLPADTTGHLLRRTPSDYSSPVETVLLTALAESLSAAHGRPSVTFDVERHGRDSRLPGPDRSAAVGWFAGVHRVTLDSFTLEAESDAGLRDAVHHMKEAMAAGPADRLECDIEAAPANPGTIMFNYSGHLETQFQAEHFRAALGAAGEERSARQERSHDIELEVEVADGRLTFRWLYAPALHRRQTIESVARRCMSTIELLVRRGPEVRATRVPSDYPLASVTREQLDRLLKETGRADDLYDLTPLQSGMLLHSLMGGGYGGCHVIECAPGLDESDVLDVWRELVERHPVLRSSVHWQGLERPVQMVHPVESVEIGIADWSESLIDTASDQDRAWRPRVTVARMGDDRLKVVLNCHHLWIDGWSVGVLTDEASRLHEALTGGGGQLPAPVPYRRYVEWLRAPERQRAAHTYWTDRLAGSRACYLGPPGGGSGGGERLLTVDLSAATRSDFQRLVSRNGVTPAVAALAAWAVAVSAAVGRDDVMVGCVVDGRAWDLAKIDRIVGLVMNTVPVVWDPAGPATVASALTGLRDQLSDTVRHGYHSLADLQRRVPGSQGEPFDTLFVVEDVSDASSGRPYQRELGYEEVHYPLSLTLLVENGQPVALRFSFHEGGLGSERVRALAAHVVTALGLMASDASGPATALRTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ57</accession>
    <name>A0A7K2ZQ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001631">
        <property type="protein sequence ID" value="MYW34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="30773" checksum="6A84C0DB987C30FF" modified="2021-04-07" version="1">MILVTGATGAVGREAARLLAAAGPVRILARRPERVTVRGPQVDIVAGEYGDRASLDRALRGIDAVFLVTNSPTEPDDARVAAAAAAAGVRHLVKLSMMAVEEPDADDFITRLQRGNEQAIRESGVPWTFVRPRTFMSNTLSWAKGIASDGVVRALHGRSPVACVDPRDVAAVAVAALTGTGHEGRAYGVSGPEAISAYEQTAQLSEALGRPLRFEELPLDRAREALLAKYPRPVAEAFLESAERQRAGAKAAVVPTVEELTGRPARTFRTWAADHAESFGAVGRAGRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ68</accession>
    <name>A0A7K2ZQ68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HK97 gp10 family phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_35685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001627">
        <property type="protein sequence ID" value="MYW34475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="109" mass="11694" checksum="32667F9BE66ED788" modified="2021-04-07" version="1">MNGIRVELDEDAIAGLVHDPAVQTDMAVRADAVVGVAKLTAPVDTGLYRATIHRVERPDPASGAVHVDAPVHYAIYVEYGTRQTDRNGRRIHLPRHVLGNALDAAGGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ98</accession>
    <name>A0A7K2ZQ98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001638">
        <property type="protein sequence ID" value="MYW34551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="23356" checksum="71BFD7B5B804C92E" modified="2021-04-07" version="1">VGRVEWRGTVLTLLGLGALLLTAGGSAPHETLTLPEALGVGAATMAVVAGLSRPGARPGLRHAAASGITSGVASALTQTLTVAVTDHSGGPLFSWRLLTVALLVSAFAMGGLLLSQTAYRGGLGAPLAVVTLANPVAAAAIGLALLGERLQGGPVSLVLALLGTAAAVRGVILLSRAQVHGGTDPGEAAAASGPVADPLPSRVVIGSPRRAESTPLGAEPLAVRVEPLAVRAGARPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQA0</accession>
    <name>A0A7K2ZQA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001631">
        <property type="protein sequence ID" value="MYW34512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005509">
        <property type="entry name" value="AfsA_hotdog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03756">
        <property type="entry name" value="AfsA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AfsA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="AfsA" evidence="1">
        <location>
            <begin position="171"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="31430" checksum="377D673FD897E758" modified="2021-04-07" version="1">MELVHRSRAEDAFPRNWERLGPDRFHVEAVLPHDHPFFAPVGADRHDPLLVTEAMRQAAMLAFHAGYGVPVGYHFLMADLDYATHPDHLVVGGLPTVIDVEVTCSELKWRGGLPVQGRVDWVVHRAGRLVATGMGATRFTNPRVYRRIRGGSAEPGVVIPRTEPVDPARAGRARAQDVVLSESSREGVWELRVDTRHPTLFQRPNDHVPGMLLLEAARQAACLAAGDGGFVPAEGRTHFHRYAEFGSPCSIAAEVLPGGPPGEARIRVTGHQDGEPVFDTVLTGPVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQA2</accession>
    <name>A0A7K2ZQA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">gyrA</name>
        <name evidence="11" type="ORF">GT040_35835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001630">
        <property type="protein sequence ID" value="MYW34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="30"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="837"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="548"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="879" mass="96914" checksum="B29AA0D74EEC1EF7" modified="2021-04-07" version="1">MADENTPVTPEPATPEEVTVPGVGMRVEPVGLETEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYDGGYRPEKGFYKCARVVGDVMGTYHPHGDSSIYDALVRLAQHWSMRMPLVDSNGNFGSPGNDPAAAMRYTECKMMPLSMEMVRDIDEETVDFQDNYDGRNQEPTVLPARFPNLLVNGSAGIAVGMATNIPPHNLREVAAGAQWYLEHPEASHEELLDALIERIKGPDFPTGALVVGRKGIEEAYRTGRGSITMRAVVAVEEIQGRQCLVVTELPYQTNPDNLAQKIADLVKDGKVGGIADVRDETSSRTGQRLVVVLKRDAVAKVVLNNLYKHTDLQSNFGANMLALVDGVPRTLSIDAFIRHWVTHQIEVIVRRTRFRLRKAEERAHILRGLLKALDAIDEVIALIRRSNTVEIAREGLMGLLEIDEIQANAILEMQLRRLAALEHQKITAEHDELQAKINEYNAILASPERQRQIVSEELAAIVEKFGDDRRSKLVPFDGDMSIEDLIAEEDIVVTISRSGYVKRTKTDDYRSQKRGGKGVRGTKLREDDIVDHFFVSTTHHWLLFFTNKGRVYRAKAYELPDAGRDARGQHVANLLAFQPDEKIAQILAIRDYEAVPYLILATKGGLVKKTALKDYDSPRSGGVIAINLREMPEGGDDELIGAELVSAEDDLLLISKKAQSIRFTATDDALRPMGRATSGVKGMSFREGDELLSMNVVRPGTFVFTATDGGYAKRTPVDEYRVQGRGGLGIKAAKIVEDRGSLVGALVVEETDEILAITLGGGVIRTRVNEVRETGRDTMGVQLINLGKRDAVVGIARNAEAGREAEEVDGADDAESETAEVHAESVVEGTVEGTEPSTGEHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQC2</accession>
    <name>A0A7K2ZQC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_36145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001641">
        <property type="protein sequence ID" value="MYW34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="3">
        <location>
            <begin position="266"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="575" mass="58736" checksum="12FFA19A1484B624" modified="2021-04-07" version="1">MPTTTPARATDPPGIPAPPRLGHSPALSSGAGRAVARIAAFAVCQAAMIAGLGLLITGPARNIWPLSAEDALNEAFERVRTDTLTTASAVVSGAGDTSTVVGLTVLACLALLVVPPFPRWRAALFLALGVWLQSVVFLLITESVDRMRPDVERLDASPPTSSYTSGHTGAATALYAGLAVLVLSRVRNRWGRAVGALLLLIPLLVGLARLYRGMHHPSDVVGGLLNGALSLFVVGRAVLADDAWAARPPADAVDIAVAAAESRPGPGRESAVVIVNPTVTDTATRDRLRLVLAQRGHKDVAFVETTERDTGGGQAADAVRGGAGLVVACGGDGTIRAVADALAGTGVALAVVPCGTGNLLARSLGLPLDPVDALAAGLTGERRALDLGAISGDGIARTHFTAMAGAGLDATVMESTSDRAKSALGWPAYVLAGLGQLRSPRLRLAVALDGGPALHRTARLVLVANIGTVQGGTALVPGARPDDGLLDLALFDPRGAGGWLRVVGVLLRGSRPTGGGTANGAHGGPVEFFTFRHAELTFTRPQPREVDGDPVTPGRRIIAEVRPGALTVLLPAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQZ5</accession>
    <name>A0A7K2ZQZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class E sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_37130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001684">
        <property type="protein sequence ID" value="MYW34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="250" mass="27092" checksum="16486E87D6379BE1" modified="2021-04-07" version="1">APPAGHATAPSAPMSRMEARRAAKAAKDSPAVVASRAVGEIFISLGVLMLLFVTYQLWWTNVRAEQIAGQEKSKIQEEWAKGAGKPGVFAPGQGFAIMHIPKLDVVVPIAEGISNEKVLDRGMLGHYGEGKLKTAMPEDKQGNFAVAGHRNTHGEPFRYVNKLTPGDPIVVETRDAYYTYEMTSVLPSTVPSNISVIEPIPVGSGFTKPGRYITLTTCTPEFTSTYRLIVWGKMVDERPRSEGKPKALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRI3</accession>
    <name>A0A7K2ZRI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001729">
        <property type="protein sequence ID" value="MYW34943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513265.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001729.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="31884" checksum="8E6267A735CA1540" modified="2021-04-07" version="1">MKLGAVIITMGDRPDELRALLDSVIAQEGDRIEVVVVGNGAPVGSVPAGVRTVELPENLGIPGGRNVGIEAFGPSGADVDALLFLDDDGLLPGRDTAELCRQAFAADPRLGIITFRITDPDTGATQRRHVPRLRAADPTRSSRVTTFLGGANAVRTRVLAEAGPLPEQFFYAHEETDLAWRALDAGWMIDYRADLVLHHPTTAPSRHAVHHRMVARNRVWLARRNLPAPLVPLYLGVWLLLTLVRRPSPPALKAWFGGFREGWATPCGPRRPMKWRTVWRLTRLGRPPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRJ8</accession>
    <name>A0A7K2ZRJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ureB</name>
        <name evidence="3" type="ORF">GT040_38380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001738">
        <property type="protein sequence ID" value="MYW34994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="103" mass="10860" checksum="B180AABB1B862E94" modified="2021-04-07" version="1">MIPGEILYGDGGIALNEGRPVTRLTVLNAADRPVQVGSHYHFAEANSGLRFDRQAAHGLRLHIAAGTAVRFEPGIPVDVELVPLTGRRIVPGLRGETGGALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS14</accession>
    <name>A0A7K2ZS14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_38510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001747">
        <property type="protein sequence ID" value="MYW35019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="12036" checksum="635C50F1E276EFBF" modified="2021-04-07" version="1">ARLPEPPRVRPDGPPAPAAPAATVAEGSAAAVVREIWQEVLRLDDIGPDEDLFDLGGHSLTITAIAARIRKRLGVEVPLDVFFDTPTLTGVSDAVDELQQTAADSEAVRKSGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS80</accession>
    <name>A0A7K2ZS80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_39585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001796">
        <property type="protein sequence ID" value="MYW35216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029886211" evidence="2">
        <location>
            <begin position="29"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="73"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="34523" checksum="E3D93614B230A7CE" modified="2021-04-07" version="1">MSVRRSITLAIATLTATGLLTACGNPDASTDVAAPKGKKDTGINISPDQDRLRGKKVDAIAALVPEDIRKRGTLRIGASADAVPPLGFFATDDKTRIGSEIDIATLLVDTLGLKPDFGQVSWENLFVGLDSSKFDAVLSNVTVTEERKEKYDFATYRLDNIAFEAKKGSGWKVTGPEDVAGKTISVSSGTNQEKILVEWSEENVKAGRKPVDIKYFQRENDYYLALQSGRIDLHLGPSPSAAYHVESAGQSEIVGQISGAGGGLQGKIAATTKKDSGLVKAYAAAIDHIIEDGSYGKVLERWGLTGEAVEKSEINPPGLPKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z687</accession>
    <name>A0A7K2Z687_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000029">
        <property type="protein sequence ID" value="MYW27848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="76" mass="8243" checksum="D2DC1AB507C611D4" modified="2021-04-07" version="1">MSAAPAPGPRDAKQQQPHAQPSQEPKPKPKPVLIFDDPLDQQSADDTDRGWGERPSNGSGAADLARFLDEKPPHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Q0</accession>
    <name>A0A7K2Z6Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000071">
        <property type="protein sequence ID" value="MYW28020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="373"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="732" mass="78114" checksum="03FEA535097A7C98" modified="2021-04-07" version="1">TDGAGGTNGAGGHGADSPGRVLVAAELGALRQWESRLALLQGLATQSPVGLAIYDTDLRLTWSNTAYEREIGKPLAEYRGKRADELYSGGTFVTPGYPQTLDAVMHHVIDTGEPILDLHFQGIPPSDPGTEHLWSCSYYRLQDANGHVFGVCEDAFDISDRQRAQQRLALLVEVGRRIGTVLDVVTTAEEIAEVTVPEFAAAVRVDIARVTVMSGELPATGSSAAMDLLRVGEHSMDPAAADAAEPLYPGAPGSPADHCPPVAYPPGSPQDRSLASGGLVLDDNVLVVPLRVGGSVLGLVTFVRSPRPELSDRPLSRGPANTFDNGEVALADELAARAAVCIDNARRFTRERSASLALQRQLLPHHVPPQSAVEIAYRYLPSDDVTGVGGDWFDVIPLSGTRIGLVVGDVVGHGLQAAATMGRLRTSVRAFAQLDMAPDELLTRLDDLVGQPWDERPGTRDGAASDAYDELTTGATCLYAVYDPVSRRCVMARAGHLPPAVVHPDGRVTFPDLPAGPPLGLGGLPFESMEVELPVGSLLALFTDGLVEARDHDIDQGLDALGRVLGDPAAALEELCDRAVSELVPDATTADDTALLLARTRQLDEGQVAEWELPAEAVAVGRARELATRQLGVWGLEELCFGTELVVSELVTKAVRYGGGPLRLRLIRDRTLLCEVADTGHTSPHLRHSAEDDEGGRGLFIVAQLVQRWGTRYTPAGKTIWTEQAFPPVEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6R5</accession>
    <name>A0A7K2Z6R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000077">
        <property type="protein sequence ID" value="MYW28036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="21421" checksum="8089654B43A02F3A" modified="2021-04-07" version="1">MLQEPQIPESAQGPRVTPAAGRTAPTPRPVPGPRSAATPRPGRPVPGPARPTPPAQRAHPAPAPAPAPVAPTGAPSRPENRSAPQLQLIPAPAGGALDAAEEAVDLLLESGRAPGDILVLTTGEQHPWAAHELSFGDGAYWAQQDAGDDVFFADASAIDRAKPRPIVVVAVNGDADDTVARALPVARDRAAALLIVCGDPQTINSALGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6V9</accession>
    <name>A0A7K2Z6V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_02020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000097">
        <property type="protein sequence ID" value="MYW28079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="27274" checksum="CA35E98CB26C66DF" modified="2021-04-07" version="1">RAAMVFQHFGLLPHRTVLDNVAYGLEIQGLSKAERRAKAAELVEKVGLAGLEDRRPSQLSGGQQQRVGLARALAVDPSVLLFDEPFSALDPLIRREMQDEVVRLHREEGRTMVFITHDLSEALRLGTRIALMRDGGIVQLGTPEEIVGSPADDYVREFVRDVPREQVLTVATAMRPALAGESERGPAVRPDATVYEAIEAVSRSGDPAARVMDAGRLVGVVDQACLLDVVAGTTDPGTVTAPDAPDGPREVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7E0</accession>
    <name>A0A7K2Z7E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000140">
        <property type="protein sequence ID" value="MYW28267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="9316" checksum="39B905EB3E0DCD59" modified="2021-04-07" version="1" fragment="single">TVVAANGVAMTAFLWHLTAMLGVYGAMLALDVPLPGPATAAWWAQTPLRLAAAAALTAVLVAAFRTFERPAPTAPVQGHGPLAALGATLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7H6</accession>
    <name>A0A7K2Z7H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="21574" checksum="0F68F3474C1FA4F0" modified="2021-04-07" version="1">MADTRNADLTFGASDYLVYAAPLNTVAPSAFADPAAAWINCGWVTTEGGLFKIEEESKDVEAAGALEPIRTLMTKSVKSLQVTFLEALNPVVRSLYDNVPVASLEPTTDIASYDLPDKPNDLRYAFIFDTMDGDKRMRLYMPNGKVTERGDEQPQTTGEMALQMTFKFYKGATAAAVKRSIDYGGVDVSTFFPDETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7R2</accession>
    <name>A0A7K2Z7R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000147">
        <property type="protein sequence ID" value="MYW28362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="316" mass="35025" checksum="BCFA8B299F00492B" modified="2021-04-07" version="1">MTETGSRDVEHEITISAPAAEVYRLIADVTNWPRIFPPTIYVDQVAEGPGEERIRIWATANGEAKNWTSRRTLDPEGLRITFRQEVSAPPVAAMGGAWIIEPIGAAASRVRLLHDYRAIDDDPESLEWIDQAVDRNSRSELAALRTNVELAHAAAGLTFSFEDTVRIAGSAKDAFDFVNEADRWHERLPHVATVRLTEDTPGLQELEMDTRAKDGSTHTTKSYRVTFPHHRIAYKQTTLPALMTLHTGYWTFVEDGDGVTATSQHTVTVNTENIARILGPEATVEDAKGYIHTALSTNSTATLQHARAFAEQRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z805</accession>
    <name>A0A7K2Z805_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000187">
        <property type="protein sequence ID" value="MYW28484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="81" mass="8545" checksum="A1CB1110770C6D15" modified="2021-04-07" version="1" fragment="single">DRLGEYQAQAAVAALHADAPTAAETDWVQIVEWYDELARLTDSPVVRLNRAVAVGEADGPRTGLAALAELDGALPRYAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8H6</accession>
    <name>A0A7K2Z8H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000214">
        <property type="protein sequence ID" value="MYW28622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030566028.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000214.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046263">
        <property type="entry name" value="DUF6296"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19813">
        <property type="entry name" value="DUF6296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="82" mass="8893" checksum="D19CF8DD56937B93" modified="2021-04-07" version="1">MEHTERYELIFQMSGAEDDVVTVRLTDRTGAGGSPVYEDETGIVRAEISDRGEVRMLASGGHQVPGTPLLARPLVEGVPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8N7</accession>
    <name>A0A7K2Z8N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000231">
        <property type="protein sequence ID" value="MYW28665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="180" mass="19432" checksum="5A2273FBC9401587" modified="2021-04-07" version="1">SRLLTEAVRAGHSEPAAVVRELSAAKLLGRPVVVGAVEALLAAGRAVAEERLYAMVREHGLPEPLWNVELRLPGGPELGGADAYWPDLAVAVELDTRAPRSGAPEEGRRGGNRGAGRVEDPQWSAYAARRDRLERLGVTVVHLTPRKLREAMDQQATVVRTALMAANDREPAAYLVVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8X1</accession>
    <name>A0A7K2Z8X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_05680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="25022" checksum="CAD66DB46FFD4509" modified="2021-04-07" version="1">MTRVLLAEDDASISEPLARALRREGYEVEVRQDGPTALDAGLQGGIDLVVLDLGLPGMDGLEVARRLRADGHTVPILVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRGASEPVAQPSTHGVRIDVESHRAWMGEEELQLTAKEFDLLRVLVRDAGRVVTRDQLMREVWDTTWWSSTKTLDMHISWLRKKLGDDAANPRYIATVRGVGFRFEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z932</accession>
    <name>A0A7K2Z932_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000275">
        <property type="protein sequence ID" value="MYW28870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="355" mass="39386" checksum="1EE4185C60D60563" modified="2021-04-07" version="1" fragment="single">MADMPRTNHEPDVSVIIGAYDAMPYLVRCLESVEAQTIGAGRLEIVAVDDGSTDGTGACLEEFAARTAIPMRVVRQPNSGGPSGPRNLGLKLARGRYVFFLDADDYFGEEALERMVAMGDRAGTDVVLGKIVGVNRGAAKSMWKETLDHADLYESNVKFTLSAQKLFRRDLLVRLGMRFDEQLKTGEDALFTMEAYLRGNGISVVADYTCYYLVGREDGNQMTKKGDHRRRFDSARALMELVAGLVPPGPRRDSLMVRPFVITLLPQFGPGLVNQSDAVRREKAALAAPLMDAYWTPEVGRRLKVHERLRLTALARGRLDLLLDIAAFLRDKKEPEVVRQGDRILLAYPHFARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z998</accession>
    <name>A0A7K2Z998_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_06420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000297">
        <property type="protein sequence ID" value="MYW28916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="263" mass="28439" checksum="B2E24A9B115DD3D0" modified="2021-04-07" version="1">MDPVTLSPKDARTAAPSLDVSGLAYAYPDGHQALFGVNLTVGRGERVAVLGPNGAGKTTLVLHLNGILEAGSGTVHVAGLPVAKRHLAEIRRRVGIVFQDPDDQLFMPTVREDVAFGPAAAGLRGPELEERVLRALKQVGMEEYVARPPHHLSFGQRRRVAVATVLAMEPEILVLDEPSSNLDPASRRELADILRSLDVTVLMVTHDLPYALELCPRAVILSEGVIAADGRTQHLLCDEELMRAHRLELPFGFDPRSVTVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9A3</accession>
    <name>A0A7K2Z9A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000299">
        <property type="protein sequence ID" value="MYW28934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14982" checksum="7780C830C2A360EB" modified="2021-04-07" version="1">MTSKKHPEWVPAAGHQLHLTGIHFDAIRLRGIRGEAVLHHLATLTEGEPGPVVREMAGARWTYFLIPPGASDGYDWPPGVKCFGSATRDEWVGIPAPDGNTYPLSWRCGAPEEDEFVDPELLHGLVMAQLAPAAHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9A9</accession>
    <name>A0A7K2Z9A9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">hemC</name>
        <name evidence="9" type="ORF">GT040_06400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000297">
        <property type="protein sequence ID" value="MYW28912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="6"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="228"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="310" mass="32788" checksum="BA151C5A33334AD3" modified="2021-04-07" version="1">MSVDLIRIVSRDSPMALAQVERVRAELAVLHPRTRTEVVPVKTTGDKWMGDLSAVEGKGAFTKEVDAALLAGEADLAVHCVKDIPADRPLPAGTAFAAFLRRDDIRDALIHPGGLPLDELPAGTRIGTSSVRRAAQLAASHPHLLCVPMRGNANRRLEKLAAGEADALLLAASGLERIGRPDVITEILSPEVMCPPIGAGVLALQCREGDSDLIDAVSGLGDPAAHRETTAERMFLHVLQGHCNSPIAGYAQVERNGDMSLRAKVFTPDGKTVLNAHEWAGPLDPATLGTSVAVALLRQGARELIDGIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9B2</accession>
    <name>A0A7K2Z9B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000298">
        <property type="protein sequence ID" value="MYW28929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="256" mass="26889" checksum="EE1B43B45C65EEC5" modified="2021-04-07" version="1">MSLPSVLAVHAHPDDESLFSGGVLAQHAAAGARTAVVTATWVEGSHRAAELARALEILGAGAPRLLGYADARVPESAPGRPRFLDTPLDAAVGAVVGHIRAVRPQVVIAPDPYGGMTGHPDHVHAHRVTALAVRAAGLARLFPEAGEPWQPSALYLATHPRSAAEEVGKHLGRPGTPTDAFYVSDDSWITTTVDVAPWLPQKLAAILAHRSEVERGAAPGRIAALPPEVQHQVLSTEWYIRQDLAPRGAADTSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9E1</accession>
    <name>A0A7K2Z9E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000301">
        <property type="protein sequence ID" value="MYW28959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="8987" checksum="0B7D3A82AD86E139" modified="2021-04-07" version="1">METNGTTEDAPVTQGDEHHVLLSADTNGDGKPDVWMTDTTGDGVADLYQFDTTGDGTIDVTVVEGAEEPGTDRLVVEGDGGHPQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Q2</accession>
    <name>A0A7K2Z9Q2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000331">
        <property type="protein sequence ID" value="MYW29086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029887155" description="Glyco_hydro_114 domain-containing protein" evidence="1">
        <location>
            <begin position="39"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_114" evidence="2">
        <location>
            <begin position="53"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="30109" checksum="DFFFBF26F745B822" modified="2021-04-07" version="1">MPQHAATPFLRRRSTLAALAGGVAVTAGAGFLLSSAFAAKPAPKVVLPKADATFDYQIGGAYTPPAGVKALSRDRGAKPVRGLYNVCYVNAFQTQPDAMDWWQKKNPDLLLRDGSGEPVNDEAWGEALLDTSTAAKRTRLAKIVGGWIDGCAKAGFQAVEPDNLDSYERSGGRLTKAHNGAFAKLLATRAHAAGLAIGQKNTTDLLGQRKSIGFDFAVAEECGRYDECADYATAYGNRVFVIEYTARDFSKACSAVGAKLSVVHRDLDVRPAGQKGYVFRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9S7</accession>
    <name>A0A7K2Z9S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/LC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000313">
        <property type="protein sequence ID" value="MYW29025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006128841.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000313.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14047" checksum="7B32B3946706A616" modified="2021-04-07" version="1">MIQQRGNMDWMLKELADDVPSIHQIVVLSSDGLRIAMHGGDPDVADRLAAACAGLQSLAAAVATEIPYSDGLMKLVVIEVTGGFFYLMAAGTGAYLAVLAGETVDAGLVGARMRDMVVRIGAHLTSPPRHGGQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9U1</accession>
    <name>A0A7K2Z9U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_07385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000339">
        <property type="protein sequence ID" value="MYW29103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="24"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="180" mass="19428" checksum="8443026A3FD8EB6E" modified="2021-04-07" version="1">MPWKPPAADDPFQQLVRAQAAARPAGLGKRFAARLVDNLVLGTVVGAVAIPLGTQAMDHIDRKITAAKQTGETVTVWLLDSTTGTLLGALIAAFLVLGFLLEALPTAKWGRTLGKKIFGLDVRDIESHDSPTLGAALRRWLVYGVLGLLVIGVANVLWCLIDRPWRQCWHDKAARTFVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA06</accession>
    <name>A0A7K2ZA06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate synthase large subunit</fullName>
            <ecNumber evidence="17">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">gltB</name>
        <name evidence="17" type="ORF">GT040_07730</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="17"/>
    <dbReference type="EMBL" id="WWKE01000358">
        <property type="protein sequence ID" value="MYW29169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="28"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW29169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1519" mass="164105" checksum="F1A732F5ED5969EB" modified="2021-04-07" version="1">MRIDAWSPMDGRPAQQGMYDPRNEHDACGVGFVATLTGVASHELVEQALTVLRNLEHRGATGSEPDSGDGAGILCQVPDAFLRAETPFELPEAGSYAVGIAFLPADGSTEAVRTIEEIATQEGLTVLGWRDVPVTPALLGNGARATMPEFRQVFVADGESAGIVLDRKAFVLRKRAEREAGVYFPSLSARTIVYKGMLTTGQLEPFFPDLSDRRFASTVALVHSRFSTNTFPSWPLAHPYRFVAHNGEINTVKGNRNWMKARESQLASSLFGQAQLDRIFPVCTPDASDSASFDEVLELLHLGGRSLPHSVLMMVPEAWENHDSMDPARRAFYQYHSAMMEPWDGPACVTFTDGVQVGAVLDRNGLRPGRYWVTDDGLVVLSSEVGVLDIDPAKVVRKGRLQPGKMFLVDTAEHRIIEDDEIKASLAAEQPYQEWLETGEIELSDLPEREHIVHTHASVTRRQQTFGYTEEELRVILAPMARTAGEPLGSMGTDSPIAALSERPRLLFDYFTQLFAQVTNPPLDAIREELVTSLRSSLGPQGNILEPTAAAARSVTLPFPVIDNDELAKLIHINADGDMPGMKAATLAGLYRVGGGGDALAARLEEICTEVDTAIEDGARLIVLSDRHSDAEHAPIPSLLLTSAVHHHLIRTKQRTQVGLLVEAGDVREVHHVALLIGYGAAAVNPYLAMESVEDLVRAGTFIENIEAEQAIRNLIYALGKGVLKVMSKMGISTVASYRGAQVFEAVGLDEEFVATYFNGTATKIGGAGLDVVAKEVAARHTKAYPASGIAASHRALEIGGEYQWRREGEPHLFDPETVFRLQHATRNRRYDIFKQYTDRVNEQSERLMTLRGLFGFTSGRAPISIDEVEPASEIVKRFSTGAMSYGSISREAHETLAIAMNQLGGKSNTGEGGEDADRLYDPARRSSIKQVASGRFGVTSEYLVNADDIQIKMAQGAKPGEGGQLPGHKVYPWVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANPQARIHVKLVSEVGVGTVAAGVSKAHADVVLISGHDGGTGASPLTSLKHAGGPWELGLAETQQTLLLNGLRDRIVVQTDGQLKTGRDVVIAALLGAEEFGFATAPLVVSGCVMMRVCHLDTCPVGIATQNPVLRDRFSGKAEYVVNFFEFIAEEVREILAELGFRTIEEAVGHAELLDTDRAVTHWKAQGLDLAPLFYVPELPDGAVRHRIIEQDHGLTKALDNQLIKLAADALGADSPEAAQPVRAQVAIRNINRTVGTMLGHEVTKKFGGAGLPENTIDITFTGSAGQSFGAFLPRGVTLRLEGDANDYVGKGLSGGRVIVRPDRGADHLAEYSTIAGNTIGYGATGGELFLRGRTGERFCVRNSGATVVSEGVGDHGCEYMTGGHAVVLGETGRNFAAGMSGGVAYVIDLDRDNVNVGNLGAIEELTDTDRQWLHDVVRRHHEETGSTVAEKLLAEWDTAVTRFSKIIPSTYKAVLAAKDAAELAGLSEQETTEKMMEAATNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA64</accession>
    <name>A0A7K2ZA64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000357">
        <property type="protein sequence ID" value="MYW29165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="140" mass="14546" checksum="F3C422507265CA7D" modified="2021-04-07" version="1">MGRIVVGVDGSDPSIKALRWAVRQAELTGDTVEAVNSWEYPATSWASMMPGLPEDFDPQALALVSLNEALEEALGAEGAAAVSKIVVIGNPAQSLLDRAQGASLLVVGARGRSAFKATLLGSVSLHVTQHAPCPVTVVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA67</accession>
    <name>A0A7K2ZA67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-formylglutamate amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000368">
        <property type="protein sequence ID" value="MYW29229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007709">
        <property type="entry name" value="N-FG_amidohydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05013">
        <property type="entry name" value="FGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="28402" checksum="54024B5872683F1E" modified="2021-04-07" version="1" fragment="single">MSTAAQQSFHLLPGSPDSPVLLHVPHGSRTIPEEVRDGILLDDGALERELDHITDAHTAELATRAAEFCSVRPWRHINALSRLVVDPERFPDDREEMRAVGMGAVYTHTTHRERLRAPDVDQRPLLASYFHPYAQALTEAVDARIAATGRAVIVDVHSYPSKPLPYELHSTGPRPPICLGTDPFHTPPELRALAETAFAGFGGTGVNSPFAGTYVPLKHYGTDRRVTALMIEIRRDTYMTEPGGPAGPGLDALAGALAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAU3</accession>
    <name>A0A7K2ZAU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000422">
        <property type="protein sequence ID" value="MYW29476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="201" mass="21798" checksum="E34ECBA60288951A" modified="2021-04-07" version="1">MRIRSARRSDLRLLQDIERAAGEPFRTLGMHSVADDDPPPLDLLESYRRAGRCWVASDPLSATGDRPLGYVIADPVDGALHIEQISVDPVAARRGIGRTLIDRLAALAPGQGLTALTLTTFSDVPWNAPYYARIGFRVLHERELTDGLRTIRGEEAQHGLDRWPRVCMRRDLLPAQPSAPAPNPASAPAPESASVAVSGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAW0</accession>
    <name>A0A7K2ZAW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000438">
        <property type="protein sequence ID" value="MYW29507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="90" mass="9865" checksum="D2FA5C2D5FD8C3AF" modified="2021-04-07" version="1" fragment="single">PPRNPRALADACIALLRDPERRARLGAAARARALELFTVEQNLAAFRGIYLELISHAPVRREADALDADGEPRLFAAPAEARLLGPWTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB66</accession>
    <name>A0A7K2ZB66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000444">
        <property type="protein sequence ID" value="MYW29515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029867288" evidence="1">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="245" mass="26165" checksum="4E1ED25A11D59CDA" modified="2021-04-07" version="1">MAGGAAAVFTAAAAVPAGAAEGGASFSRVQVNGGKPIVIGTSKEVAIPASFRVVTTRAWKWAPLVYLYRNGADDMLWHNIGTNDCPHRVGSCDIAETLYFNPSLWMMRNSEAGVWKVAGQVYFKDGSKDVDATGLTVHVKRNSRLTVNAAPEPVAKGKTITVTGKVTRANWETRKYAVYGGRHVSLQFKPSGTDSYTTVKKVYANGSGALRTTVKAAKTGTWRWAYYGNTTTGASMSPGDHVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB99</accession>
    <name>A0A7K2ZB99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000465">
        <property type="protein sequence ID" value="MYW29636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022118">
        <property type="entry name" value="Peptidase_C70_AvrRpt2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12385">
        <property type="entry name" value="Peptidase_C70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029896362" evidence="1">
        <location>
            <begin position="30"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="21584" checksum="AB7ECEB66BDE4292" modified="2021-04-07" version="1">MLSPRIARTAAAAALAIAGTLAGAQSSVAAVLPYTQEVQKGGYWCWAATAVSIQKYHGSQIDQDRFCHVARNIPANRPCPDEGLAWPNIVKGYNATGYSAKWTQSHLPFPTVKREIDADSPFVMGVTWTNGPSVNSQHTVVVYGYDDSYSTANPTVSYADPGPNSQRRTTVAWNDLGVRTPTSQFRWTDTIYNIRKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC44</accession>
    <name>A0A7K2ZC44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000520">
        <property type="protein sequence ID" value="MYW29878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="22531" checksum="50FAADC86E929F2F" modified="2021-04-07" version="1">MTTDDARTSWDGIYAARPVATDPQPNVRLTETVADLPPGDALELGCGEGGDTLWLARRGWRVTAVDVSEVAVERLTTLARSLGLGDRVTAERHDLGATFPDGPEGGFGLVTAHYLHTPYDLDRAAVLRRAAHALRPGGRLLVVDHGSTAPWSWNQDPDASFPSPQEVADGLALDPAAWTVERADAPRRTATGPDGTTAEVTDHVLVVRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCB1</accession>
    <name>A0A7K2ZCB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000549">
        <property type="protein sequence ID" value="MYW29973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="800" mass="85356" checksum="5D78EA03E7E24449" modified="2021-04-07" version="1" fragment="single">MITTGGSALRSLVRALPGPDADPVLMFVEGAAGEGKSHLLQELADLQELADLQGPADRRGPADPPGAPDLARLWWRCGAEGGPPEEDEHRREPALWLVDDVHRAEEDELRRLRRVLEGLERGSAAVVTYRPEELPVPGLPLGSPPMAYPNRPTVLMSRLAPWDEERVRRAAEALGEGGGCTDEAVTRIHERTGGVPRVVVDLLAMVRGQWPAFTGTAAEVDAAGVPPRLAELVLSRTHALSPEHRPVVWAAAVLDGPVGREELIAVSGLGAATGNSALLRALESAALAEPAEGRYGFAVPLAASAVRATVPGPVRQDLHRRTANVLSRRHPVSWAAVAEHHRAAGDGPRWLRAVEKAAESAETSGRHQQAITLLERTLATPDIPPQARARLAPLLARNAVTGLRSDQTVEVLAQIVQDAALPPAVRGELRLDLGLMLCNQMGRFPEGWRVLEIAAAELRDVRSPLAARAMAALVLPYHPGVSLDVHQGWLIKAVAAADDSGDEAMRTAVLANHVGLAMSWADPEAWELVAKLPVESTDPACARQAARGLCNAADSAVWLGFYGRVDDLLTRGRELSARTGAPYTEHSALGTLLLQAWWTGQWLGLAERCEEFITATADMPLIASDAYLVRGLLAVAQGDWGEARSWLLQRGTFGTENLPVPLGAAAAGALIRLALARQEVGVAAEQARSAWKVVADKGVWPWAAELAPWAVEALVRAGDSGTAHTMVRNFAQGLGRCDAPAARAALVWSRAVLTETDAPARERRDGLLEAAKLYGEAAAAYAELPRPYSQALTMEGAARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCL5</accession>
    <name>A0A7K2ZCL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="24456" checksum="65619E3DADC2682A" modified="2021-04-07" version="1">MEDQSVVDVGDVRLAYRTWGDPFGSPVVLLHGLGGSTADWEAAGPLLGQEWRVFALDLRGHGESDWPDEYDLELMAEDVVGFLDELELNRVGLVGHGMGGVVARLVAHEHSDRVERLVLIETPAPFPGDPGPAGRPEGPVDYDENAVPAVRDQLADPGPDADEGLGEIVAPTMIITGGPESRMPQDRQADMASLIPDCRLITVPGGHRMHQTRADQVAAHITEFFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCL6</accession>
    <name>A0A7K2ZCL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4352 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_12705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="4">
        <location>
            <begin position="88"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="20928" checksum="B7F80E7088F348E0" modified="2021-04-07" version="1">MSYQQPQPGQPQQPGWGQQPPPAPKKKTGKIIGLGCLGVVGLFILIGIIAAVVGGGDDGNESSATPPAVTQGDTKKDEPKKEKKDEEPAKKATVTVTAKQVDFKKSVLAQGDDYTSIQVTITNNSKNDLDINPLYVTITDTSGSKHTAELGVDEDQLDMVKLAPGENVTGTITGKGKFDAKYVTYTDGLIGDSVRGNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCN2</accession>
    <name>A0A7K2ZCN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketopantoate reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000596">
        <property type="protein sequence ID" value="MYW30089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="30719" checksum="2E663E1DF8F91877" modified="2021-04-07" version="1">MKLLVHGAGVCGSLLAAQLHEAGADVSLLARGRRLESLRRHGVRLAEEDSPVVRQVPVPVVEHAADGYDLAAVTVRTHQVDAVLESLAGFGGDVLFLHNWAAGAQPLEEVVGRGRVLLGFPAVGGTMDGDVVRHRASNPVTDRVAMPIGEPDGRTTPRLERIVRVFRAAGVNTKAEPRMDAWLKTHAAFSVPLGRAAYTAGGPAALAEDSDAVRAMLRLMRQNLAALPTPPVPRPFGALDKVPEGVLVPLLRRFLRSRTAVRSGLSDTSPATAAELDRLAGQLRALTQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDR6</accession>
    <name>A0A7K2ZDR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol phosphodiesterase</fullName>
            <ecNumber evidence="2">4.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphatidylinositol diacylglycerol-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphatidylinositol-specific phospholipase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_14265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:17093"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58484"/>
            <dbReference type="EC" id="4.6.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511129.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000665.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004436">
        <property type="term" value="F:phosphatidylinositol diacylglycerol-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="PLCXc" evidence="7">
        <location>
            <begin position="58"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="307" mass="33208" checksum="888BECB57648A033" modified="2021-04-07" version="1">MSTPPNHPAPSGLLTTRRGFLAGALAVSATAVIGAAPAVAATRKAVRGTQDWMGGLPDGTALQRLTIPGTHDSGARFGGPWAECQNTTIAQQLQSGVRFLDVRCRITSGSFAIHHGAAFQNMMFGDVLIACRDFLAARPTETVLMRVKQEYSSESDAAFRAVFDDYLDGRGWRSLFRLDSTLPTLGGARGKVVLLADNGGLPGVRYGDPAVFDIQDDYMAEPFAKYPKIEAQFRKAAQQPGKFFMNYVSTAALMPPRWNADRLNPQVHSFLERSETAGWTGLGIVPLDYPNQRGGLVESLIRHNPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZED7</accession>
    <name>A0A7K2ZED7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000733">
        <property type="protein sequence ID" value="MYW30696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="6770" checksum="BE9D29E695FAF217" modified="2021-04-07" version="1" fragment="single">MSRRVSLPGADELFRTTGGGMGLQSSSPADRRRKANGEPRVPAPAGESDASGRSSEAGEEHASADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEE0</accession>
    <name>A0A7K2ZEE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PQQ-binding-like beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000742">
        <property type="protein sequence ID" value="MYW30723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="417" mass="43576" checksum="139FF2F0AC9D26DB" modified="2021-04-07" version="1">PAAATGWVRPPAGLNGAAGTPTAPVPAPGPAPDTAPAAPDRWRPWRFRMSNDVWGTPVVSGDLLYVTSFEIHALDVGNGRRQFKTRDVAWAMAVEGGRIHASDGPSLYALDAAGGAEQWRVRTDAWVYALKADRGTVLTATRGGGVQGWEASNGDKLWEITGAQSDFETAEAAPVIHDGTVYVWQDARLRALDARTGLERWSYPIGDAASCGGVPVRVTPAPDGYVYIAAGTRVLAVDTVSGRVRWHFESPAVFLSPPAFAPGPAVTGGGVYLADYLGTVYALDATTGKDRWRIATEARASLEPVLVAVGNVHVGSGSALYTLDAVTGTPKWRFAAGGDVVGAPVVADGRVHFGSADHVLYTLDAAGGQLRWKLATGGEITGSPVAQAGVVYACSKDRCVYALDALKGTGTGNRART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEG2</accession>
    <name>A0A7K2ZEG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotin carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000741">
        <property type="protein sequence ID" value="MYW30722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="111"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="412" mass="45025" checksum="A669B5A177B2BE74" modified="2021-04-07" version="1">MIVIHRWRDRHAHYEEYVDHRTHRVTYVTTELALDSVPGGAAAARTVQATDDLDAVWRAVTELRTHFGVPERVVALNEGDLDTAAVIRERLGCAGQTSAALARFRDKLTMNQVTADADIPAPAFADAPDEAAVLAFAERHGWPVVVKPRRGTASRGVVRLDSEADLPLLRTSPPEPRLVQRFCADPIFHIDGLWTGEKLGPWRASRYVNTCVDFTQGEALGSVEVDDPELLRPLREFTTRVARALGPEPWVFHLEAFVGTSADGSPSIQFLEAGYRVGGAEIPFVWREVHGIDLAGAAADVQLGRRPHLPVPDVWRTGGWLLVPSPVPAPCRVTAWELPEPPAPDEGPYAVVVPAVGQVVPRVGGYEHVGARFRFRGGSSGDVEKAILRTAAQFRLECVPERGARVACGLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZET4</accession>
    <name>A0A7K2ZET4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretion protein Rhs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000762">
        <property type="protein sequence ID" value="MYW30795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="2">
        <location>
            <begin position="415"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1534"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1582" mass="171644" checksum="777DF697DFF40A01" modified="2021-04-07" version="1">MGFGDFVRDITPDVVEDAVEDGVEWAGDRVEDAGNWTGDRLDDAGWESGADWVREKSRSVANRMGAEVDEMDLGQTEDKTKLIYGSPSEIRSTATHLRKLQGAFDKVGGGLKGVDSSALKGQAADAFRNSVSVEPPKWFKAADAFEKAAGALDSFAGTVEWAQGQAQTAIDKWKAGTKASEEARDAFNEKTTTYNKAVDVYNAKPADERDPSTLPPKPETFSDPGTARMTEAQELLAEARKQRNTAAETARKAVTAARDAAPQKPRYAEQAMDGLAEYQVIKTHLAGGVVKGAAGILTFARSVNPMDLYNITHPAEYGLALNNTAAGLVRVANAPWGTGKQMLDDFMKDPAEGFGRLLPDAALTVATGGAGAGVKGARVVKEAADIASDARRLERHAPEGTHNRPDGERTTGGTDPVDLASGRMFLPQTDVVLPGVLPLAFTRRVESGYTAGRFFGPSWSSTVDERLEIDAAGVIHVTDDGLLITYPHPVPGLTTLPESGTSRSALSRDDAGYYTLTDPETRLTKHFAGPPGAEPGEDGTAWLVQMTDRNNNTITLDRADDGTPLALVHSAGHRLILTVAEARVTGLSLMDGTGAVHPLRSYGYASGNLSTITQPSGAALTFEYDDARRITAWTDSNQSRYAYVYDEHDRVIAAGGEAGHVELALSYGRPASATGHRVTTLTTADGHATRYLIDARCRVLATTDPLGHTTRSTYDSHGRQLTRTDPLGRVTDFTYDEQGRLLTVTRPDGSRLTTKHDPSGGHRETRGPDGARRLQVFDEQGNLTAVTDAAGHTTRWNFDAQGRPTSVTDALGATTTIRCDTVGMPTEVTDPAGGTTHVKRDALGRPVLIADPAGGTTRLEWDVDGRLARRVAPGGATESWTYDGEGNCLTHTDPVGGVSSFDYTHFDLPAARTHPDGTRYSFGYDAHLQLIQVTNPQGMQWSYAYDAAGRMISETDFDGRTVSYHYDADGQLSSRTDALGQTISFKRDQLGRVIEKDAEGRMTVYSYDQAGRLLQASSPDSELLYRYDRRGQVKTELVDGYAMAYAYDAVGRRTRRTTPTGQVTTYAYDSGGRPAHLTAGGCRVGFTHDVAGRETARVFGGFLTVTSAWDEVGRLSAEELTADGRALNGRCYSYRSDGHLTELSDRLSGSRTFDLDAVGRVTAVHARGWKERYAYDADGNQTEAVWPATHPGSDGAGPRSYTGTKLIRAGGTHFEYDALGRVTLRRRARLSRKPEIWRYTWDAESRLTSVITPDGTRWRYRYDPLGRRTAKQRLSTDGGTVVEEVRFAWDGLTLCEQTMREPALPNTVVLTWDHRAGVPLAQTERILTADTRQDEIDRRFFAIATDLVGAPTELVDESGDIAWRTRTTIWGTTAWARTSTAYTPLRFPGQYYDPETGLHYNLFRHYDPGAGRYVSPDPLGLAPGPNPVAYVDNPFTWCDPLGLMPKCPKERARKVSDQVIERAQEGKMRKSGNYHADTRHQFSDDRVLEILKNPDAVYHSQGQRGNLTFRQGEDVVITKGPGAGAGDVITAYGPSGTRGESGAKAFGGSPDDPGLPVTHDDIVNGNIPDSRGGTLAPADQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFF7</accession>
    <name>A0A7K2ZFF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_17660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000827">
        <property type="protein sequence ID" value="MYW31058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="3">
        <location>
            <begin position="80"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="18544" checksum="A4EEBED3A86815A0" modified="2021-04-07" version="1" fragment="single">MQKKRPRSQGSTRDGSGATPPAPVATKRTVRVRSRLVAGVAVVGVIVLAAGAPAALSASSDLAESQRLVTLSELNQRAVTLAHSLADERDAVTAYIAGGRADDGDAAAANRLTRTTRVDQQIDEIHEPAPAALRRDLSTVPSLRRDALTGKGSALEAHQAYSEVIAKLHGIAAELADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFF8</accession>
    <name>A0A7K2ZFF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_17445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000815">
        <property type="protein sequence ID" value="MYW31015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="12"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="239" mass="25049" checksum="D8A31DA12AD64060" modified="2021-04-07" version="1">MTDRKAQLAANLAQVEERITSACAAAGREREEVTLIVVTKTYPASDVRMLHELGVRHVAENRDQDAAPKATACADLSLTWHFVGQLQTNKVRSVTSYADVVQSVDRVKLVTALSAAAVRAERELGCLIQVALDAESGERGERGGVAPDGIEELAAAVDAAEGLRLEGLMTVAPLAGPFAGRQRAAFDRLMEFATRLRAGHPAATMVSAGMSADLEDAVAAGATHVRVGTAVLGVRPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFP9</accession>
    <name>A0A7K2ZFP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molecular chaperone Hsp90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000854">
        <property type="protein sequence ID" value="MYW31105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12042" checksum="2595446853BC8AC6" modified="2021-04-07" version="1" fragment="single">MNATEGADPFGTARLRRGVLDAWGAGPARFREDANAEEDLALGGYRDRLVVELAQNAADAAARAGVPGRLRLTLHPAAPGDPDGRCVLAAANTGAPLDATGVESLSTLRASAKREGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFY4</accession>
    <name>A0A7K2ZFY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000874">
        <property type="protein sequence ID" value="MYW31273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="42"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="364" mass="38509" checksum="4CACA2CF18B9B04D" modified="2021-04-07" version="1" fragment="single">MNGAPDARGVVAGFCGELLSDPRHRDDPVLGDIAAQCRQPLRVLLVGDVSAGKSTLLNALLAGHHARTAHRETTSTVTWFHGLGPEAVRLPDPTHRGVRVDFPLARRLMIADAPGLNTKSEKARHTLRMLPGGDLAGAAAAYVFLLLRGRADGEAEALGNLTAMTAGPFDLVGNVVAVAGKADEVASDHAEIEERVPREARVPIRAVAVHQKMAVAARVAEVSAPLLSALASIRTRPELMARPTLGWPHLTGHLSEAQLAGLTAALGSPAWLPELIRRTADSATAEDVLRVVEEMSRIPVLEAVLADMADDEDLFTATGAVLRLRNWAARPGSGDGASVREGLRALQTTAAFDRLRARAAARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG22</accession>
    <name>A0A7K2ZG22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000876">
        <property type="protein sequence ID" value="MYW31280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="173" mass="19715" checksum="F299030CB63A3215" modified="2021-04-07" version="1">MEHMTTASTASTGATRWLTDEEQRVWRAYLHATTLLEDHLDRQLQRDAGMPHIYYGLLVQLSQAPRRRMRMTELARNVKITRSRLSHAIARLEKNGWVRREECPSDKRGQNAVLTDDGYAMLGRSAPGHVDAVRQALFDRLTPEQVRSLGDIMRVLAAGLEPEGTDADLPWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGB9</accession>
    <name>A0A7K2ZGB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000912">
        <property type="protein sequence ID" value="MYW31411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="220" mass="23713" checksum="2D9B85AB53726DC4" modified="2021-04-07" version="1">RRLADALSRLNRTEEALGLLYEALRACRALGEVEGVREVRLSLVRAYDSGGAPRRALPHARLALAMAERTGDPQALADGLTAVAQQWERLGEHAGALDHARRALELYTALGHLDGQAGILICMGHAERGLGRPAAAVGHYEVSLDLDRALGDRYREAHALGHLGDAHLALGGEEQARARWEEALAIFEDLHHPDAGPVRAKLRTPAVNYPPVPASSQHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGE5</accession>
    <name>A0A7K2ZGE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000913">
        <property type="protein sequence ID" value="MYW31412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="27503" checksum="F270CAEA6A9846EE" modified="2021-04-07" version="1">MVLTTLTAPPAQAAPTGIVVSNVVVNNGKPIVVGTKEAKEPPVTFQVSLPPGLSTSKPSAYDAKPFLYRGAKLPKNPDNDSLRMGIYTCYPVNDRKERCEGTLFIDPPYDLASNSYATTWKVGLTLRLWKPDGRLKAEEFKKAPGSVQLKRWAKATVNASPEPVKKGKKLTVTGKLTRADWTKHKYTAVAGSARLQFRKKGSSAYTTVKTVKSNSAGALKTTVTASVDGYWRWTHNGSSITGPATSTADFVDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGF5</accession>
    <name>A0A7K2ZGF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000909">
        <property type="protein sequence ID" value="MYW31385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029827518" evidence="1">
        <location>
            <begin position="36"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="457" mass="49843" checksum="B23B296A1E38D082" modified="2021-04-07" version="1">MRPHPRRRHGPRRRLPRTAATAAALALLATGCAGAGGTSFGGGDALNVLMVNNPQMVELQKLTKEHFTKETGITVHFTVLPENDVRDKISQDYSNQAGQYDIATISNFELPFFAENGWLRPLDSYVDADPGFDQQDILTPLRESLTHKDGKLYAQPFYGESSFLMYRKDVFEKEGLTMPAKPTWKEVAELAAKTDGSQRGMKGICLRGLPGWGEVIAPLTTVVNTMGGTWFTEDWQPQLTSPEFKKATKFYVDLVRQHGELGAPQSGYAECLNNMTQGKTAMWYDATAGAGSLEAKGSPVKGKIGYVPAPVEQTKSSGWLYTWAWGMQNASKKADDAWKFISWASGKEYEELVGATSGWSNVPAGKRASTYAHPDYRKEAGAFADVTQQAISEADPNNPGTQPRPTAGIQFVGVPEFTDLGTKVAQEISAAIAGRQSVDAALATSQKLAEKVAEEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGG1</accession>
    <name>A0A7K2ZGG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1080 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_19395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000908">
        <property type="protein sequence ID" value="MYW31379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029553974" evidence="2">
        <location>
            <begin position="24"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="4">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="663"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="989" mass="108023" checksum="F8A2A282DF62B26A" modified="2021-04-07" version="1">MRRLAVLVSALFLATLVPGQAAAQPPDIPPQEPGVTMRVFDVQMVLEDFCTLKPGQTPNIDELKPTIDWTTAEDFGMDGKFVTEVTAYLDVESAGKHDFRITSDDGSRLIIDGTQIIDNGGKHGARPKEGSVELTEGHHALRIDHWDGEYDQRLLLEWRPPGASAFSTVPTSVLSTDADVTRVTSPGRKVCEGIDESPGDGLPLAGVHPDYTLTDLRPDGFEPQVTGMDWLPDGRLAVSTWGGSRESKLGQVYLLDNVTGNTDPSKVTKKLIAEDLLEPMGLKYVDGTVYVSEKNGLTALVDKDGDEVADEYRKIATWPFGGNYHEFAFGLLYEKGNFYVSTGIAMVPGGATQDPQNVPNRGSTLKINKKTGKVSYVAGGLRTPNGLGWGPQGEIFATDNQGAYVPTSKLVRIKQGAFYNHHTNPDGVYDDQPVTEPVLWLPHGEISNSPSNPMLLPKGPFAGQMVFGDVTYGGLQRAYLEKVGGEYQGAVFRMTQGLEAGVNRISLGPDGAIYAGGIGDSGNWGQEGKLKFGLQKLTLTGDQAFDMRAMRAVDGGFEIEYTQPLSEETAEDLTAKYQAQQWRYVATPRYGGPKADEETLDVTSATLSADRRTVTLKMDGLRPGYVVHVQSPRPFAAENGEELWSTEAWYSLNTLPDGSKAPPVYEAESASLSGGTKFNDNHSGYSGTGFIDNNWEPGSRTTFAVRADKKGKHDLALRYANGQNSDPEPKPRSMTLYVNGERHKQIWLNSTVAWNKWATHTESVPLRKGANTITYAYEPEDDGHVNLDNLTVTPSKRTTLFDGTDLDAWESNNGGPAAWPVADGSMESYGGDIRTKETFGDFRMHAEWYQPDYPADVTGQARGNSGVYIQERYELQILESFGVKVPAKDDAGSIYLRKAPDVNAATAPKTWQTYDIEFRAARFGSDGKKTQDARVTLRWNGKVVHNDVAIAGPTGAGRPEGPAPGHIKLQDHGDPGENPRFRNIWIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGU3</accession>
    <name>A0A7K2ZGU3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folB</name>
        <name evidence="3" type="ORF">GT040_20445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000967">
        <property type="protein sequence ID" value="MYW31581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514312.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000967.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="13071" checksum="61EB51A93200829D" modified="2021-04-07" version="1">MDRVALRGLKARGHHGVFPKEREEGQTFIVDLVLGLDTRPAAATDDLARTVHYGVVAEEVVEVVTGEPVDLIETLAERIAQQCLKHEGVQEVEVVVHKPDAPITVPFDDVTITIIRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH84</accession>
    <name>A0A7K2ZH84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000973">
        <property type="protein sequence ID" value="MYW31619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="16598" checksum="0BD41BF32F27D58B" modified="2021-04-07" version="1">LDLLVDDSDGVVLGRLRIPAPTPAAGAGAPHTGVTAVWDTCRSLMTSLVRPAVPGAVTAPPGTYRLRVEADGVLLSDLDAPVRGVSVLSQGDGGLADVVVSTSDGEDVTVEAKAVTVSGADFRYRADIQTGGPVRTRTWTVRAGAWGLMLPLPASADGARGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH99</accession>
    <name>A0A7K2ZH99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001007">
        <property type="protein sequence ID" value="MYW31731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="18490" checksum="8786AC1678AF691A" modified="2021-04-07" version="1">VLPERWSGPLVPVGEEEIVLVVPFDDPPAGRPSVGLHELADRPWVRCAMEPVVDGRPFLDGVCGAAGFEPRTAVWTEHTSTAIRMAAAGVGISTAPSHTVRGVLGEDCGVLSVDPPWLRALAVFSRVALTGAAAAFTELITALPDTGIRPLRPFRPGDPSPERAYADCAGPPAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHB3</accession>
    <name>A0A7K2ZHB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L,D-transpeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_21210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001005">
        <property type="protein sequence ID" value="MYW31727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="93"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="22804" checksum="8101A69D6BDC3C22" modified="2021-04-07" version="1">MRIGSEGAQVRELQARLRQIGHFGRTPTGYYGTVTAEAVRSFQAERGTEATGATDAVTWRKLLAMTRTPTADELDPPTERPVAEPDRRCLTGRVLCISKKSRTLAWMIDGRVVSAMDVRFGSEYTPTREGEFPVFWKSRDHVSTLYDTPMPYALFFSGGQAVHYSADFAANGYGGASHGCVNVRDKAKVAALFDQVKNGDKVVIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHF4</accession>
    <name>A0A7K2ZHF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="17425" checksum="9D98CDF563419939" modified="2021-04-07" version="1">MTERPVVKRTARAILLDGDDLVLIKRTKPGVDPYWLTPGGGVEPEDATVVDALHREVDEELGAKIVDVVPCFVDTVEHIADGGVTGVKVQHFFVCRLASMDVTRRHGPEIDEPCGEYEIVRVPFSRVGIAAVHLVPLSLRHYLDGNIEGVRAMHAPDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHG7</accession>
    <name>A0A7K2ZHG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001018">
        <property type="protein sequence ID" value="MYW31801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966321.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001018.1"/>
    </dbReference>
    <dbReference type="GeneID" id="63982749"/>
    <dbReference type="GeneID" id="66955589"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046086">
        <property type="entry name" value="DUF6104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19599">
        <property type="entry name" value="DUF6104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="7350" checksum="B7B0EC8F8118EDA2" modified="2021-04-07" version="1">MYFTDRGIEELEKRRGEEEVTFEWLAEQLRTFVDLNPDFEVPVERLATWLARLDDEDDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHM4</accession>
    <name>A0A7K2ZHM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_21900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001029">
        <property type="protein sequence ID" value="MYW31856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="251"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="472" mass="48931" checksum="94AA8C25D4834C7A" modified="2021-04-07" version="1">MVFVLVALVVLALLASVHRYVWRRFVGDTTAPGSTLRKVGTVAAFVLPLLSLGAMTSGRIGAPFWLQQVLAWPGFLWLACLMYLTLALLVGEVVRPLLTRVLARRDAARATAGTGTSGTAVDGTLAATTSGTRPRTEELVPASRSCPSNSADPAPATAPAAEPEAEAVRDTEQAAPAAPADTEPAEADPAAPAPGLALPSRRLFVSRVVGGAAAAAGLATVGYGTANVLRGPSVKRVTVPLAKLPRAAHGFRIAVVSDIHIGPILGRAHTRRIVDTINSTSPDLVAVVGDLVDGSVADLGSAAEPLAGLRARHGSFFVTGNHEYFSGAEQWVNHVRELGLIPLENARVEMGGFDLAGVNDIAGETEGQGPDFVRALGDRDRGRAAVLLAHQPVVIHDAVEHGVDLQLSGHTHGGQLWPGNYLAELANPTVAGLEQYGDTQLFVSRGAGAWGPPVRVGAPADITVVELASRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHR8</accession>
    <name>A0A7K2ZHR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2510 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001044">
        <property type="protein sequence ID" value="MYW31902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2510" evidence="2">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="50" mass="5488" checksum="18CCCD83F926439D" modified="2021-04-07" version="1" fragment="single">MSFATPPGWYPEAGTPGTERWWDGTAWTAHTRPAAAHPAPYEPAHPPYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHY4</accession>
    <name>A0A7K2ZHY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_22270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001060">
        <property type="protein sequence ID" value="MYW31925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="373" mass="41193" checksum="05B2E10FF536322E" modified="2021-04-07" version="1">MSNNVALPDQQGTTEKTGERRELLTVEKMAMHFPIYGGFPIKRKVGAVKAVDGIDLTVYEGESLGLVGESGCGKSTTGRMMTRLLEPTGGKITYQGQDITHASRKELAPIRSEIQMIFQDPYSSLNPRQTVGTIVKSPMEVNGIKPPGGREARVRELLELVGLNPEHYNRFPHEFSGGQRQRIGVARALALQPKLIIADEPVSALDVSIQAQVVNLLQKVQREMGIAFVFIAHDLAIVRHFSERVAVMYLGKVVEVADRDSLYNRPRHPYTHALLSAVPEANVDTGAKERIRLEGDVPSPIMPPSGCRFRTRCWKAQDKCATEEPPLVQIGGNRAGHLTACHFPEDPTTEPRDEDVVMDPALVALEEEQEAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHY5</accession>
    <name>A0A7K2ZHY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ORF">GT040_22485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001062">
        <property type="protein sequence ID" value="MYW31966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030076797.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001062.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW31966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="508" mass="54366" checksum="708A4BCB52556BB4" modified="2021-04-07" version="1">MPRGDGRLNHDLLPGEKGPQDACGVFGVWAPGEEVAKLTYFGLYALQHRGQESAGIAVSNGSQILVFKDMGLVSQVFDETSLGSLQGHIAVGHARYSTTGASVWENAQPTFRATAHGSIALGHNGNLVNTAQLAEMVADLPRKDGRATQVAATNDTDLVTALLAGQRDEDDKPLTIEEAAAKVLPDVKGAFSLVFMDEHTLYAARDPQGIRPLVLGRLERGWVVASESAALDICGASYVREIEPGELVAIDENGLRTSRFAEAKPKGCVFEYVYLARPDTDIAGRNVYLSRVEMGRKLAAEAPVEADLVIATPESGTPAAIGYAEASGIPFGAGLVKNAYVGRTFIQPSQTIRQLGIRLKLNPLKEVIKGKRLVVVDDSIVRGNTQRALVRMLREAGAAEIHIRISSPPVKWPCFFGIDFATRAELIANGMTVDEICTSMGADSLSYISIDSMIEATTIDKPNLCRACFDGEYPMDLPDPELLGKQLLETELAAGPAATAAADALRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIG6</accession>
    <name>A0A7K2ZIG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_23360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="71"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="171"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="382" mass="43263" checksum="FC5BF2D89BB9C0AA" modified="2021-04-07" version="1">MATRKPQRRREFGTVRQLPSGRWQARYWAPDGSRRTAPETFSTRTDAQTWLTLTQADIERKHWFDPDAGAVNFAAYAVQWVEERGLSATTEELYRRLLRLHLLPTFASVNLDDITPPGVRTWRAERLEATGATTVAKSYRLLKAIMETAADDELIRRNPCRIRGGGSERAKERPTATVEQVDALADAMGPRWRLMVYFGAYGPMRPEEQAALRRPDVTLEPLAARISDAAPELTTGRWVEGDTKSTAGRRTVFLPTFLRIEVERHLDWYAEKEPNGLLFVGEWGAPFRRSTFGRKWRRARAKVGLPEDFRFYDLRHTGHTLSTQSGATLKDTMVRAGQSSEKAALIYQHSDGERQREVAGGIDARVRAARQKAVAQPGARET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIJ5</accession>
    <name>A0A7K2ZIJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coagulation factor 5/8 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001109">
        <property type="protein sequence ID" value="MYW32158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029841729" evidence="1">
        <location>
            <begin position="26"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="29"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="721" mass="76348" checksum="25F93CC1F8D3ACF5" modified="2021-04-07" version="1">MPLLALGGLVGSLLTAVATAPAAQAAELPTGWVTVTAAHSGKCVDAAAAGTADGTAVQQYACNGSNAQQWQFRSVGGGYVRVDNRNDAAKSWDVTNVSTADAAPVQLWSYSGGLNQQWLPVEEPGGSFHFVNRNSGKCLDVPAASTADNARVQQYTCNGSAAQSFRVGATDVPNPPGTPDLGPNVSVFDPSTPRATIQNKLNQVFAQQETNQFGSQRQALLFKPGRYDVDANVGFYTQVAGLGLSPDDVTINGGVHVEADWFQGNATHNFWRSAENLSVNPPSGTDRWAVSQAAPYRRMHVRGNLQLDDGGWSSGGFMADSKIDGQVRSGTQQQWLSRNSHWNSWTGSNWNMVFVGDVNAPANSFPNPPYTTVAQTPVSREKPFLYVDGAGAYQVFVPALRTNTQGTSWGSGAPAGQSLPISQFFIVKRGATASQINAALAEGKNLLFTPGVYRLNQTINVTRADTVVLGLGLATVVPENGVTALSVADVDGVKIAGILIDAGTVNSPTLMQVGQAGAGARHTANPTSLHDVFFRIGGAAVGKATQSLVVNSSDVIGDHLWLWRGDHGSGIGWNTNTAATGLIVNGTDVTMYGLFVEHYQQHQVIWNGNGGRTYFFQNEMPYDPPDQAAWMNGSTRGYDAYKVSPSVTRHEAWGLGSYCFFNVNPSVVAERAFEAPNAPGVRFRNMVTVSLGGTGTINRVINNSGGPSNSSTNVANLVAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIM7</accession>
    <name>A0A7K2ZIM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17078" checksum="1D209258AE70103E" modified="2021-04-07" version="1">MPSYGEQPQPTYYPTPLPPQYGQPPAPAYGQHVVPLPQGAVVYPPTAGLDGVVMMPGPNGQPVAYYTPPPAPAPQPYVSPLLVKAALVAFIVGVAGVGVYFLAAAILELAKALAIIAGVALVGFVLLKMLVTGPGSGRSINVNARGRAKVQVHTGRGHNRGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIN3</accession>
    <name>A0A7K2ZIN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001112">
        <property type="protein sequence ID" value="MYW32210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="34858" checksum="9E2771E75300735C" modified="2021-04-07" version="1">MSTLTPPKPDAAETSEASLGGSVRVLLRLHRRSLWAAGVLLVLGIGTVIALLAWVAVQRCPDEDATGCGNGDLYMVTTAQSAAESLLSGGGSALLLLACLVGAFVTGPLIARELESGTFRMAWAQSVSPAQWLAARLAVPAALSVTGVGLLSVVYRWGWTEVRNANAFGLGWFEDGVFPGIGPAAVGYTLFGVAVGALCALLIRRMLLSMAVTTVVLGVVMTGFTRRRRMLWPVDRILGNGYPGPNTWTTETGMLTASGEKLFWRDCPSMGADHDGVGCMKARGGVTDFTDYHPASHFWPLQLVETGILLALAALAVFVSFRVLRRLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIU2</accession>
    <name>A0A7K2ZIU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001124">
        <property type="protein sequence ID" value="MYW32270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22369" checksum="D23ADBEE1B0F38AA" modified="2021-04-07" version="1">MKGALLDRAARAAIAELEAEDDVEFGVRLLRNTPTHERRDPALLRHWAATADAFGAGLEPVAATARVVESDGGLAKGLLARYTSRPVPTVELFTDTLALADELIDLLGWRHRYPAGSVRAAAIAHEAVHERLHHGPAKKSLKRALNHVVLRAGRHTLYGHVAGADEIAAHAHARTVCGLGRSPLLLTAALATAAEPQHGSPQGSPHGREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJB9</accession>
    <name>A0A7K2ZJB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001152">
        <property type="protein sequence ID" value="MYW32349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="362" mass="38568" checksum="15918B3434F63E99" modified="2021-04-07" version="1">MGKVVLVTGVARQLGGRFVRRVQRDPGVDRVIAVDAVAPAHPLGEAEFVRADIRQSALARILAEYAVDTVVHLDVSGKALGTAGRTAIKETNVIGTMQLLGACQKSPTVRRLVVKSSTSVYGSASRDPAVFTETTPPKSLPSGGFAKDAVEVEGYVRGFARRRPDVAVCVLRFANILGPRPDSPLADYLSLPVLPTVFGYDPRLQFVHEDDVVDVLGIAAREPRRGTLNSGTFNIAGEGVLLLSQCSRRLGKPTVPVLLPAVTWVGSALRTIGMTDFSPEQIRLLTHGRVVSTVQMRETLGFRPEFTTAGTFAEFARSRGPGLLPPETVGRAVDRLAELPLPGGGGPRERGTGAVQTTHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJM2</accession>
    <name>A0A7K2ZJM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">argC</name>
        <name evidence="3" type="ORF">GT040_25500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="341" mass="36515" checksum="22DCCCAF00FF1570" modified="2021-04-07" version="1">MIRVVVVGAAGYIGGELLRLLIGHPEVEVVGAVSSRFPGKRVDGVHPNLRSATDLLFCSADDVGECDTVFLSTPHRAAMTQIDRWIGQSKQVIDLTGDFRLDDTEVYRRYYGTEHAAPHLLGGFVPGIPELHRESLAGADLVSVPGCMAVAGVLALYPLVARGLVEPDARLDARTGSSGSGATAGEANLHAERSGAMRVFAPTGHRHEAEISRHLGIPARMTATGVEAVRGVQTICHATLRPGVDTAAVRGAFREQYRDEPFVRLVAHRRGTFRYPEPKILLGSNYCDVGYAVDEEAGRLVTIAALDNLMKGGAGNAVQCLNIRMGWPEELGLSFPGLHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJQ3</accession>
    <name>A0A7K2ZJQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="644"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="682" mass="72902" checksum="C1AD1A302B485AB4" modified="2021-04-07" version="1" fragment="single">MTEPIAPHVLLSPAHFTDVRRRVGDYGDRTIAEASAIGLAYWATGAGPDGIDLTPGTSFADVLGWVDNGGGGSPGWEVGADGLSVTLPDGVRPDEAQLALDDLAGFPDRPVGTIGPSSIAARTETLARWNDNRADRVRPTLMELFREQARARPDAVAIVDEHRTLTYRQAAERSAQLAHHLTGRGLGAEQVVGISLGRSADMVIGLLAVLQAGCAFVPLDPQWPAARRAVVIEDAGVVLQLNSSGGSDATEPDAVAVDLGDWGFGSYPAEAPETAVHATSLAYVIFTSGSTGRPKGAMIRHEAISERLLWQREEILRFGHDDASLFKAPLSFDISINEIFLPLVSGGRLVILRPGGERDPHHLLSVIAEQRVTFTYLVSSMLDVLLEIEAGSGRLDSLRHVWCGGEVLTPELYERFRTRLDIPMYHGYGPAETTIGVSHVIYRGEAERLSTSIGKANPNTQLYVLDDELRPVPVGVGGELYVGGLLLGRGYVGAPGLTASRFVANPFASDGSRLYRTGDLARYAPDGSLDFLGRADNQIKIRGMRLEIEDVEASLAEHPRVRHTCVVARKNSAGGTYLVGYVIPSGGGEELTADEVTAWATAHMVEYMVPAHLVVLTEFPLTANGKIDRAALPEPTRPTGGLVAPATENERLVCAAVAAVLRVDGVGVDQDFFQLGGDSILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJV7</accession>
    <name>A0A7K2ZJV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ORF">GT040_25525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="402" mass="42306" checksum="D2EA309C744616E7" modified="2021-04-07" version="1">MTATTDAISAQEHAALADHWSAPNYHPMSVVLAQGEGAWVTDLDGRRYLDFVSGYSALNFGHRHPDIVAAAKAQLDRLTLTGRSFHNDQFGLFCSELAELTGTEMVLPASTGAEAVESAVKIARKWAYQVKGVPDGAAEIIVAGANFHGRTTTMVSFSTDPSARNGFGPFTPGFTVVPFGDLDALTSAITENTAAVLLEPIQGEAGVVVPPRGYLAGVRRLCDETGTLFIADEIQCGLARAGATLALDDENVRADLYTLGKSLGAGLVPVSAVVGRADVLGVLKPGEHGSTFGGNPLACSVARAVVRLLATGEFQERSRELGTYLHSCLEAVEGVAEVRGRGLWAGVQIAEGRPTGHRVSEAMAERGLLCKENQGHLRVAPPLVITREEIDLGVDVIAKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK07</accession>
    <name>A0A7K2ZK07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EamA family transporter RarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rarD</name>
        <name evidence="11" type="ORF">GT040_26255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001221">
        <property type="protein sequence ID" value="MYW32680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW32680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="346" mass="36705" checksum="6B15D1AECAAB145D" modified="2021-04-07" version="1">MKGKNEQRAGLLYGVGAYGMWGIVPLFWPLLKPSGAIEILAHRMAWSLAVVGIALLVVRRWAWIGELARDPRKLGLISVAAATITVNWGLYIWAVNHGQVVEASLGYFINPLVTIAMGVLLLGERLRPAQWIAVATGLAAVLVLAIGYGRPPWISLILAFSFATYGLVKKKVNMGGLESLAAETAVLFLPALGFLLWLTATGASTFTAGDAGLGHGALLAATGIVTAVPLICFGAAAIRVPLSTLGLLQYLAPVFQFALGIVYFHEEMPPERWAGFALVWLALSLLTWDALRNARRNRVLAAQLLATAAAAPAPATPQVATPETVTPETATPETGTPETATQQKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK37</accession>
    <name>A0A7K2ZK37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3037 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001231">
        <property type="protein sequence ID" value="MYW32703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030567319.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001231.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021398">
        <property type="entry name" value="DUF3037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11236">
        <property type="entry name" value="DUF3037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="127" mass="13652" checksum="A91325AEB19B0ED5" modified="2021-04-07" version="1">MTRRDVFEYALLRVVPRVERGECFNAGVLVYCRAHSFVAARTHLDEAKLRALDPDADVVGVRAALRAVEGVCGGGEGAGQAAGDDAGRRFRWLIAPRSTVVQPGAVHTGLTTDPAGEVERLLDLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK73</accession>
    <name>A0A7K2ZK73_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_26520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="3">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="17744" checksum="E6AFA50E6DE18D1F" modified="2021-04-07" version="1" fragment="single">MSDEAEPGFVRVRLDLSYDGKDFSGWAKQTSRRTVQGEIEDALRTVTRSAVTYDLTVAGRTDAGVHARGQVAHVDLPEAVWAEHEEKLLRRLAGRLPLDVRIWRAAPAPAGFNARFSALWRRYAYRVGDRPGGVDPLTRGHVLWHDRPLDVDAMNEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKL7</accession>
    <name>A0A7K2ZKL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloregulator ArsR/SmtB family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001273">
        <property type="protein sequence ID" value="MYW32890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="278"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="370" mass="40785" checksum="431B6B77033A6F85" modified="2021-04-07" version="1">MNIDIAGLPSDRIVFSVSPLTELGDALHALSEPGHHPGVHGWATATSAALEPDLADRLLEAEFLWRHSFSDIFLPYAGVRGHDGRPGATLAEDLDLLDRIDDERFVTSALEFTCAGLVEPGNPSPLTNAAMRARALDMAAARGPRQVKFTQRLLADPVRVRGWIRRLFEDCDQAFFADTWRRVSVQLVADARHKTEVLRRKGVQEAMGAVSAALTLDEEAGRLSVDKLAEARTTAVDPDLGTGLTLLPSSFGWPHLMVLYAPGWRPVIQYPVRLPDLPAPASVELLQLRMEALAHPMRMRLCRNLARSAYTTGELADSHRITAPEVSRHLSVLKKAGLITTRRRGRYVLHQLDLTVVARIGSDFLEGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKR5</accession>
    <name>A0A7K2ZKR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001297">
        <property type="protein sequence ID" value="MYW32937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="81"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="20323" checksum="024294AF2EB1BF4E" modified="2021-04-07" version="1" fragment="single">MTWPRALRDVLRSGLSIEETRLEPLLALRAAVGVALLVGPALWLGSPAYAASAALGAFSAGGATFQRAWRPRKVIALGAGAGLALSTLAGYLAAGQLVTFLPLLALWTFVAGLAWAVGSTAGIVAATTVGSMLVTITLPTSAGRALEHAGIIALGGVVQALLILLFPIRRWGAHRDALADALAAVADYARRLRHDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKU2</accession>
    <name>A0A7K2ZKU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AIM24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001299">
        <property type="protein sequence ID" value="MYW32974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="22734" checksum="7D81BD07B44C2DAF" modified="2021-04-07" version="1">MPFREMNSKMIEATVVPGQKLFSQRGAMLAYRGEVSFTPNIQGGQGGFASMIGRRVAGEATPLMTVEGSGTVMFGHGGHHIQVINLAGDTLYVEADRLLAFDGSLQQGTMFMGSQGGVMGMVRGQVTGQGLFTTTLKGHGAVAVMAHGGVIELPITPGRDIHVDPQAYVAHHGDVRNKLSSAVGWRDMVGRGSGEAFQLELSGSGAVYVQASEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLC3</accession>
    <name>A0A7K2ZLC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3516 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001309">
        <property type="protein sequence ID" value="MYW33049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="254"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="837" mass="93259" checksum="49A31C845AE82B11" modified="2021-04-07" version="1">MTLIDQLPQTADPDALFEAFSSWTESQGITLYPAQEEALIEVVSGANVILSTPTGSGKSLVAAAAHFTALAQDKVTFYTAPIKALVSEKFFDLCKLFGTENVGMLTGDASVNADAPVICCTAEVLASIALRDGKYADIGQVVMDEFHFYAEPDRGWAWQIPLLELPQAQFVLMSATLGDVAMFEKDLTRRTGRPTSVVRSATRPVPLSYEYRFTPITETLTELLDTRQSPVYIVHFTQAAAVERAQSLMSINMCTKEEKEKIADLIGSFRFTTKFGQNLSRYVRHGIGVHHAGMLPKYRRLVEKLAQAGLLKVICGTDTLGVGVNVPIRTVLFTALTKYDGTRVRTLRAREFHQIAGRAGRAGFDTAGFVVAQAPEHVIENEKAVKKAGDDPKKKRKVVRKKAPEGFVAWSETTFDKLIQSEPEPLSSRFRVTHTMLLAVIARPGNAFEAMRHLLEDNHEPRRAQLRHIRRAIAIYRSLLDGGVVEQLETPDAEGRIVRLTVDLQQDFALNQPLSTFALAAFDLLDAESPSYALDMVSVVESTLDDPRQILAAQQNKARGEAVGQMKADGIEYEERMELLQEVTYPKPLSELLWHAYDVYRTSHPWVNDHPVSPKSVIRDMFERAMTFTEFTSHYELARTEGIVLRYLASAYKALEHTIPDDVKSEDLQDLISWLGEMVRQVDSSLLDEWEQLANPEVETAEQAQEKADEVKPVTANPRAFRVLVRNAMFRRVELAALDRARDLGELDGEAGWDEDAWGEALDAYWDAHEEIGTGPDARGPKLLKIEEDPAHGLWRVWQAFADPAGDHDWGIQAEVDLAASDEEGRAVVRVTKVGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLC9</accession>
    <name>A0A7K2ZLC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_28745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001345">
        <property type="protein sequence ID" value="MYW33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="341" mass="34457" checksum="66EFF0812D447594" modified="2021-04-07" version="1">MTRPARWRPALLAASLAVVLVVLCLLSLGLGALQIPPGDVLKALLGRPAGPRIEDVIWSVRVPRTALGLAAGAALGLSGCVMQALTRNPLADPGILGVSAGAAFAIVLAAGVAGIGSLLGYIWFAFAGAMAASIVVYLLGRMGRSGSTPVKLALAGVAVTAVLSSLTSAVVLTDPAALDRFRFWSAGSLANQDASTVLRILPFLGLGALLAVASAPALNSLALGDDVAASLGRKLGLVRLQGVVAVTLLTGAAVAVIGPVVFIGLVVPHVARALAQWAGLGPDHRWLLPLSAALAAGLLLGADILGRVIARPVEVQAGIIVAFIGGPFFIALVRRRRLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLE0</accession>
    <name>A0A7K2ZLE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma factor SigF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_28895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001349">
        <property type="protein sequence ID" value="MYW33177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="4">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="12473" checksum="C3F2C7C6876D724E" modified="2021-04-07" version="1" fragment="single">MTAMSVQATGATAPLSDDLAGARTDVGAEELPWVEDAGKVAPKDARALSKVFFDRLQVLEEGTHEYQYARNTLIEMNLSLVRFAASRFRNRGGDDTEDIIQVGTIGLIKAIDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLR1</accession>
    <name>A0A7K2ZLR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001351">
        <property type="protein sequence ID" value="MYW33199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515309.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001351.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="29286" checksum="7B2348543ABA1295" modified="2021-04-07" version="1">MGTPELISPRSPRVAAARRLARRNFRGKERRFIAEGPQAVREAAAHRGGDGEPTLIELFATPEAADRYADIVDAAHAAGARVHLAGDDVLADVSQTVTPQGLIGVCRFLDSPFQEILDAKPTLVAVLANVRDPGNAGTVLRCADAAGADAVVLTDASVDLYNPKSVRASVGSLFHLPVAVGVPVEQAVQGLRDAGVRILAADGAGDDDLDDELDAGTMGGPTAWVFGNEAWGLPEETRALADAVVRVPIHGKAESLNLATAAAVCLYASARAQRPRRAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLT7</accession>
    <name>A0A7K2ZLT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001373">
        <property type="protein sequence ID" value="MYW33325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="35" mass="3565" checksum="20125BA0E9F87963" modified="2021-04-07" version="1" fragment="single">MKIALMDSGIGLLAAAAAVRRLRPDAELVVSSDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLU5</accession>
    <name>A0A7K2ZLU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001375">
        <property type="protein sequence ID" value="MYW33327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="7986" checksum="1EC89F401A5D4634" modified="2021-04-07" version="1" fragment="single">MASHAKNPKAAGVLLAAGGGRRLGGRPKALLEHHGRPLVEHALRALRNGGCGPLHVVLGAAADEVRARADLTGSAVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMF8</accession>
    <name>A0A7K2ZMF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3618 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001431">
        <property type="protein sequence ID" value="MYW33545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="188" mass="20169" checksum="5DE985922AC3C3F0" modified="2021-04-07" version="1">MNDESQNKMGTPTPEELREQVERTRDELGQTVEALAAKADIKAQAKEKTAAVKEQASERAAVAREQASEKAAAVKEQAAEKTAVVREQAAEKAAAASGQIREKTEQAAQLVKDRTPDAVLEKTAQAAAQVRESAAQAKRYAAEKTPGPLLEKADRAATAARANRTPLIMGGAVLVAFLLIRRSRGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN63</accession>
    <name>A0A7K2ZN63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001481">
        <property type="protein sequence ID" value="MYW33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032772066.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001481.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7154" checksum="E7CC0655D83398D2" modified="2021-04-07" version="1">MHEELSAPARTTAPHPSSCPAPPPAGHNATTTERGSFCLARCTCGWTGPARRSRDRARTDAAEHLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN83</accession>
    <name>A0A7K2ZN83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001483">
        <property type="protein sequence ID" value="MYW33816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19030" checksum="17D7B9CEBB691E53" modified="2021-04-07" version="1">MPGFAAVPVALALCAGLLTGPAVGEPRTHCRTGPAGCYGLYTYGYGLGLHPFTSPHAVRAQLTDHFWLFPVSGGCAGRIRAGARCELLGGNPVEVEYIGNDFFQINTLPGHQLGRGMHIRFAFSRTLGFHTLTVRAWQDRATDCTGEAFCNTVNRVFAWGTWRVLAQTLRISAYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNA8</accession>
    <name>A0A7K2ZNA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1349 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001484">
        <property type="protein sequence ID" value="MYW33820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="PTHR35332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21366" checksum="2C2560BAF42DB86F" modified="2021-04-07" version="1">MTLHLDGLPFALAPEGPDGRWTHADSVLTGRAGPGQDLFVPPSGEAPACATDTPRLLGAVGDGDFRLLARVRPGLVAAGDAGALHLHLGDRDWAKLCLEHSSGLATVCSVVTRGHSDDANAFVVEDDSYWLRLSRTGNAYAFHASADGETWTFVRVFTLGTAEQRAAARVGFLVQSPTGEGCGAVFDRIAFLPGGVENLRDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNM2</accession>
    <name>A0A7K2ZNM2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferric nitrobindin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks the conserved His residue that binds heme iron in the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001502">
        <property type="protein sequence ID" value="MYW33953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511113.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001502.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="2">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="1">
        <location>
            <begin position="20"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="190" mass="21279" checksum="B235D966E4BEF825" modified="2021-04-07" version="1">MIEIPSDLHPDLVPLAFLIGKWAGAGVSDFPGAEKCNFGQEVTFSHDGRDFLEYVSHTWVLDADGNQVRPLESESGYWRIDKDRKVEVVMVRDQGVVEIWYGELADQKPQIDLVTDAVARTAASGPYTGGKRLYGYVKSDLMWVGEKATPEVELRPYMSAHLKKVVTPEEVAEMARNLEDMPDDGIAFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP88</accession>
    <name>A0A7K2ZP88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NPCBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001550">
        <property type="protein sequence ID" value="MYW34150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14244">
        <property type="entry name" value="GH_101_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040633">
        <property type="entry name" value="Gal_mutarotas_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040502">
        <property type="entry name" value="GalBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035364">
        <property type="entry name" value="Glyco_hyd_101_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18080">
        <property type="entry name" value="Gal_mutarotas_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17974">
        <property type="entry name" value="GalBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17451">
        <property type="entry name" value="Glyco_hyd_101C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12905">
        <property type="entry name" value="Glyco_hydro_101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029686054" description="NPCBM domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1292" mass="137042" checksum="30B6458AB4915423" modified="2021-04-07" version="1">MSPRFPFAGLVAVASAAVLALVGTALPAAAAADPSPAPPAGAAKPSGSVTIGSPQLTVAVADDFPRVLSYTDRAGGKQLLGSTRPVTAVTLNGTAHPVKLKGAPKVNSSSARYTLTFTGLPGVEIDASLTVSGRTTTFKVTAVRDTAAFRVGTIDIPGHDLISVGSTEPGAATAFTTLDPDSTRTADVFGKVTAATKPDPAPVGATYAILNTSSLAAAVESNSSYDKPSGPTGGDDARLWHQARTEADGSGVRVGVSSGQWTYRGEGAQTPESGENLPWAKVVVTPDVNGDRAVDWQDGAIAFRSIGITAPGSEETADRVVTHIPFNFASQATHPFLRTLDDVKRISQSTDGLGQLAVLKGYGSEGHDSAHPDYGGNYNKRAGGLKDLNTLLKQGKKWGATFGVHVNATESYPEAKAFSEQLVDKAKPGWNWLNQSYYIDQRRDINSGDLAKRFQQLRNETDRNLAFLYIDVYYSHGWIADKTIQSVQKQGWTVGTEWADKFERASLWSHWANDLNYGGATNKGLNSQIIRFIRNGEKDIWNNHPVLGQSVLEDFEGWTGETDWNAFTANIWQKNLPAKYLQQQKITRWDGNDLTFTGGVRGTVEDGKRTFYDQGRKVLSGTDYLLPWDGGRKLYHYSETGGTSTWEVPGKGPYAVYELTDNGREKTATVRPVNGRITLTATAGQPYVLYPSQAPRAADPAWGQGTPLKDPGFNDRDLTGWTKTGTAVRDTDDQGRNSAALSGTATAALSQPVTGLKPGKRYTASALIEVESGQSRRTVLSAGGRSVAVERSTAEDFVAASDWHGTRFQRAKVTFTAPANGRTTLRIEAAAGSPATVRADDVRIVENAPATRPGTLVYEDFEAVDQGWGPFLKGNAGGSTDPRTHISQLNAPYTRSGWNGKLIDDVLGGKESLKSHEENTGLVYRTAPWTVPMKDGHRYEIAFDYQSSHAGAYTWVDGYDRVAGDKATSTETRTTPIGQQRTTGRFTQTLTAGCGDTWTGLRKRAGAPEGADFVLDGFTVTDLGPAPAGQEAVCGTLGVAADAETLEPGAPNTVKATFGNDEASAATGVKLALTVPEGWQAEPVGAVAFDTVAPGAKVTGSWRVTPPVDAAYDTYQLGAEATYAVQGSPRTLGAQTSVRTLPPPPTQDSWASDLDWTASQNGWGPVERDQSNGETGTGDGRPLSIGGVAYAKGLGTHAPAKIRYYLGGKCTSLTAEVGVDDVQTTRGSVRFSVTADGTEKVKSPVLGAADPAWKLTADVTGARYVELVVDDGGDGNGNDHADWGNARFHCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPE5</accession>
    <name>A0A7K2ZPE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Germacradienol/geosmin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001548">
        <property type="protein sequence ID" value="MYW34139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="23002" checksum="FCA2AE3594335EC5" modified="2021-04-07" version="1" fragment="single">MAQPFSLPDFYVPYPARLNPHVEAARTHTRQWARGMGMLEGSGIWEEKDLEAHDYALLCAYTHPDCSAEALSLVTDWYVWVFFFDDHFLELFKRTPDREGAKRYLDRLPAFMPMERGAATPEPENPVEAGLADLWTRTVPAMSDAWRARFAESTENLLNESMWELSNINEGRIANPVEYIEMRRKVGGAPWSAGLVEYAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPJ8</accession>
    <name>A0A7K2ZPJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001588">
        <property type="protein sequence ID" value="MYW34286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016794">
        <property type="entry name" value="UCP21603_acetyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021603">
        <property type="entry name" value="UCP21603_acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="30132" checksum="E63E8C594E16A9DF" modified="2021-04-07" version="1">MTQTTTRVLEPSDLGAALAILESEPVANAFVTSRVQVAGLDPWRLGGEMWGWYADGRLRSLCYAGANLVPICAGPEAVRAFADRARRAGRRCSSIVGPAEPTALLWRLLEPGWGPAREVRANQPLMVTESPSADIAPDPLVRRIRKDETDILMPACVAMFTEEVGISPLAGDGGLLYQARVAELIGAGRSFARIDDGKVVFKAEIGAATTQACQIQGVWVAPEHRGKGLSETGMAAVLRYALADVAPVVSLYVNDYNAPARKAYRRVGFRETGTFMSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPS4</accession>
    <name>A0A7K2ZPS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001585">
        <property type="protein sequence ID" value="MYW34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16181" checksum="165DBC4D4B5551F4" modified="2021-04-07" version="1">MTGPETKAAIEWLTSVAPDPGACRWEWERNPQGIALLPAGRRWDVLILPGELGYPTLDVLTRLIDRPGPVLADFGESRMGFFVPPGTASRWLGTGIRGAGPGTWIVVPHPGRAAGGVRWLIPPDGSGTLTDAALLELAMHEAAGAAAQGDREGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPX9</accession>
    <name>A0A7K2ZPX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001606">
        <property type="protein sequence ID" value="MYW34377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="84" mass="9087" checksum="595D2C50F174AF78" modified="2021-04-07" version="1">MDARASHQEAPPAPPAPGTPLVDTSRNDRVGEFRGVAGARWSLRPIGGGIEWEADPQHVRPALPMEQIRARTARANARSRGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ65</accession>
    <name>A0A7K2ZQ65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001627">
        <property type="protein sequence ID" value="MYW34482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="30276" checksum="25FEDEE2A9E7F649" modified="2021-04-07" version="1">MAASSNQIAAAARHQSAVIRRIEQQAARDAGQPLAQALAAAQNTATRQWIHATDRQTLPSPGALDRLIKAIKQLLTEAFRGKGKLAADTIRIAAFNSAQLSARQASALAAAMSGEPPPPVQPVIGPEAVAAADAVPAAIDDEHQRALALLTTASVTALGFAGVTGVFSRARRAVTRIARHAAVAVTSAAAHAAAAVARAIGPTIRLLWVAEPGACAACAAYAGRSVPVGRRFPAALSLDPRRAVFATAPKGPPLHPHCRCWTIPYSPTWRVDGTPLPRLLRQYARAERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ67</accession>
    <name>A0A7K2ZQ67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">pgk</name>
        <name evidence="12" type="ORF">GT040_35775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="WWKE01001628">
        <property type="protein sequence ID" value="MYW34493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW34493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="403" mass="41891" checksum="9B526D6E7001C506" modified="2021-04-07" version="1">MKTIDELLTEGVAGRRVFVRADLNVPLDGTTITDDGRIRAVLPTVSKLAEAGARVVVASHLGRPKGAPDPAFSLAPAAARLGELLGADVAFATDTVGDSARSVVAGLTDGQVAVVENLRFNAGETSKDDAERGAFADQLAELADVYVGDGFGAVHRKHASVYDLPARLPHYAGYLIATEVGVLKKLTTDVKRPYAVVLGGAKVSDKLGVIDHLLERADRILIGGGMAYTFLKAQGHEVGSSLLQEDQIPAVQEYLRRAEEKGVEFVLPVDVVVAPAFPDLKTKAPADATTVAADAIPAGQMGLDNGPETNKLYASKLADAATVFWNGPMGVFEHPDFADGTRAVAQALVDSPAFSVVGGGDSAAAVRILGFDENAFGHISTGGGASLEYLEGKTLPGLAALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQP4</accession>
    <name>A0A7K2ZQP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TlyA family rRNA (Cytidine-2'-O)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001678">
        <property type="protein sequence ID" value="MYW34686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="28552" checksum="28F25885D20738B5" modified="2021-04-07" version="1">MAGVARRRLDAELVRRKLARSREHASQLIAAGRVTVGRTTATKPATQVETAAAIVVTKDDDDPEYVSRGGHKLAGALAAFVPLGLAVEGRRALDAGASTGGFTDVLLRAGARQVVAVDVGYGQLAWSLRSDERVVVKDRTNVRELTLEDIDGEAVGLVVGDLSFIPLGLVLPALARCAAPDADLVLMVKPQFEVGKERLGSGGVVRSEELRAEAVREVARRAWGLGLGVRGVTASPLPGPSGNVEYFLWLRAGAPELDPADVDRAVAEGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQS7</accession>
    <name>A0A7K2ZQS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_36370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001651">
        <property type="protein sequence ID" value="MYW34609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029663205" description="Germane domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="5">
        <location>
            <begin position="216"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="609" mass="64720" checksum="F870F56CE6F60BEF" modified="2021-04-07" version="1">MSALLGCSVIVLAGCGSMPMTGDVKAVDASQPGDSQVQVYAVEPREGAAPSEIVDGFLESMTSDDPGFRTTRKYLSKDAADTWQPGEGTTVLTQAPNRSGPSLRDEERRDSETSYTLTGEKVAAVDAQSSYQPLAPTDYSQVLHLVREKVAEGKAEWRIDTVPDGLVLGQSDFKRLYRSVNKYYYATGRTAGQPTLVADPVYVRTGTDPVTRMSTATQTVRTLLEGPTNWLRPVVDSRFPTGTALRKDVVALAPDDQNVLKVPLNGKADKAGRAACRMMAAQVLFTLRDLTSARVEQVELEGGRGRLCALDADEAAKFSSDSSSDGPDSQYFIDAKGRLQRLPGTQEGNGTPEVVRGPLGVGTVAMGAVGVARDERRAAAVSATGQNLYVASLDEEGELAAPAVTSAGKKTADRLSSPSWDGRGDLWVADRDRSRPRLLRLVEGEGEPQEVRVPGLNGGRIEELRLSADGVRIALLVTEDGHTTLKIGRVERRGTDEAPELSVEGLRQAAPQLTDVTAISWSGRSRLVVVGKEAGGVQQVRYVQADGSTPSSGASGVLPGVNQVQAVAAADDELLPLMAETEGDGIVKLSPGDNWQTVLEEGTSLVYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQV6</accession>
    <name>A0A7K2ZQV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001677">
        <property type="protein sequence ID" value="MYW34678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="31637" checksum="7F2B3939AC7CB562" modified="2021-04-07" version="1">MSAALDSLLDLLDLEQIERDIFRGTSRSAVVPRVFGGQVAAQALVAAGRTVPAERAAHSLHAYFLRAGDPGAPIVYSVDRIRDGKSFTTRRVVAVQHGQPIFHLSASFQSHEDGLEHQADMPSSPDPETLPTAAEMLPRYADRFSDPGMVDRLIEARAAVDLRYVDAPPFGTVGEAREPRSQVWFRTNGKLADDPLLHVCMATYVSDMTLLDSVLLAHGRGGWAVGDVVGASLDHAMWFHRPFRADEWLLYDQESPSASGGRGLGQARIYTADGRLAITVIQEGVVRVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRD4</accession>
    <name>A0A7K2ZRD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_38115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001729">
        <property type="protein sequence ID" value="MYW34941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW34941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="353" mass="37023" checksum="68B925EC3D5A907F" modified="2021-04-07" version="1">MPVLTRLIPSPVVVDIRRGAMDDLAGLLADQRISSSGKLAIAISDGSGRALRERLAPVLPGADWYAVADGTIDSAVRLADGIKGTRYDAVVGLGGGKIIDVAKYAAARVGLPMVAVATNLSHDGLCSPVATLDNDNGRGSYGVPTPIAVVIDLDVIREAPARYVRSGIGDAVSNISCVADWELAHEVNDEEIDGLAAAMARQAGEAVLRHPGGVGDDAFLKVLAEGLVLTGISMSVAGDSRPASGACHEINHAFDLLYPQRAASHGEQVGLGACFAMHLRGARQEALLMASTLRRHGLPVLPEEIGFTVDEFVRAVDYAPQTRPGRFTVLEHLSLSTDQIRDAYADYASTISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRI2</accession>
    <name>A0A7K2ZRI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001732">
        <property type="protein sequence ID" value="MYW34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="402" mass="42013" checksum="F8EDF6C66AE5CDE1" modified="2021-04-07" version="1">MTSFDSSPTLTAWRALLAVAVVFVMLATTGWSAVRDHQTDGERELALASWARDRIAGRPLPEAGAPAFRMAHFFATLTSGQQMSLADKYPTVVGNLNGVPVTLRYHANRLALKQAVAVEKRRTYDETLSAGGHSEAAQRVARFRSMLAKDRQILAFDPSGRGRAAEVFGDLDRASRVSVVVPGVDTNLLTLERSRRVNSAPVGMAKSLYGAERAASPWTRTAVIAWADYTAPAGLGMDAALGGLATEGALRLNALVGALPGTSTVSLFCHSYGSVVCGVAADKTPDRVADIAVAGSPGMRAESAARLDTDARIWAMRDRDDWIQDVPHLEFGGIGHGADPVDPAFGARLVSAAGAAGHSGYFEPGTESLGNFAAIGVGAYGSVSCATADGACHSGISGDREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRL8</accession>
    <name>A0A7K2ZRL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001730">
        <property type="protein sequence ID" value="MYW34947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6507" checksum="E22623C6462859FD" modified="2021-04-07" version="1">MSTTTLNPRRTGPAHGATAVTGHHRPHRVGDAVRAVKVFVTAAFSVVVLGEYAEGAGVRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRR7</accession>
    <name>A0A7K2ZRR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">cysC</name>
        <name evidence="3" type="ORF">GT040_38055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="WWKE01001727">
        <property type="protein sequence ID" value="MYW34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="20226" checksum="91E9A1716879EE0A" modified="2021-04-07" version="1">MTTDQESSMSVTETGATIWLTGLPSAGKTTIAYELAGRLRTEGHKVEVLDGDEIREFLSAGLGFSREDRHTNVARIGFVAELLAANGVKVLVPVIAPFADSREAVRKRHAAESTTYLEVHVATPVEVCSVRDVKGLYAKQAAGEISGLTGVDDPYEAPESPDLRIESHQQTVQESAAALHALLSERGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSC9</accession>
    <name>A0A7K2ZSC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_39855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="11"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW35266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="441" mass="46866" checksum="20E69FE59F9CAF6A" modified="2021-04-07" version="1">MPATPTETPAELVARLRATFRTGRTKDLAWRTGQLERLRALLTEHGDDLADALRADLGKSRKEAYRTEIDFTVREIDHTLEHLADWLRPEPAPVPPHLAPTGATAHTVLDPLGVVLVIAPWNYPVQLLLAPVVGALASGNCVVVKPSELAPATSAAVTRLLPRYLDTDAVGVVEGAVEETTALLEQHFDHIFYTGNGTVGRIVMTAAAKNLTPVTLELGGKSPVFVDRGTDLKAVAGRLASGKFLNAGQTCVAPDYVLTDPETAPALAEALAEAVEGLFGADPAEHPEYGRIVNERHFDRLTGLLDSGRTVTGGAHDRDTKYIAPTVLADVAPDAPVMGEEIFGPILPLVTVDGLDEAIGFINDRDKPLALYAFTDSPAVRDRLLAETSSGGVGIGLPLAHLTVSDLPFGGVGESGMGSYHGRYSLETFSHRKAVLDTPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSK6</accession>
    <name>A0A7K2ZSK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001836">
        <property type="protein sequence ID" value="MYW35346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7485" checksum="07E14DCA6BBCC788" modified="2021-04-07" version="1">VGAAFTSVRGLLRRSDTAELAAGAEQDLIARGRLALDRYATAPPAHLEVLARHVIAQRDGDGGREGYGDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSL3</accession>
    <name>A0A7K2ZSL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">A/G-specific adenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_39550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001794">
        <property type="protein sequence ID" value="MYW35209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW35209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="10594" checksum="73F93F07D1D29F52" modified="2021-04-07" version="1" fragment="single">MTAMTSTSPQTPPAAASLHTPVIGWFEQHARDLPWRRPEAGAWGVMVSEFMLQQTPVSRVLPVYEQWLARWPRPADLAAEAPGEAVRAWGRLGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSR6</accession>
    <name>A0A7K2ZSR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001843">
        <property type="protein sequence ID" value="MYW35395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="124"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="24139" checksum="DC1EF1D71F54824F" modified="2021-04-07" version="1">MHAQIVLFDGFDPLDVVAPFEVLHAGGTASGGSVTVELVSAEGAREVVSGTGGLTLRATAALDPERADLVLVPGASGRVGEAEDGPEEVFGEAAVDVPGAGPADVVDQPVPVLIGRTLTTGLPALLRSAMDDPSVTVAAVCGGSLVLALAGLLEGRHATTHHLGLDLLDATGAHAVRARVVDDGDLVTGAGVTSGLDLALYLLEREAGPRIAHAVEELFAHERRGTVWRDRGPVPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z641</accession>
    <name>A0A7K2Z641_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ectoine dioxygenase</fullName>
            <ecNumber evidence="6">1.14.11.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ectoine hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thpD</name>
        <name evidence="11" type="ORF">GT040_00630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate</text>
            <dbReference type="Rhea" id="RHEA:45740"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:85413"/>
            <dbReference type="EC" id="1.14.11.55"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. EctD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.55" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000018">
        <property type="protein sequence ID" value="MYW27811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012774">
        <property type="entry name" value="EctD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02408">
        <property type="entry name" value="ectoine_ThpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW27811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="297" mass="32792" checksum="0C172A532C15FA78" modified="2021-04-07" version="1">MTTEVRADLYPSRGAAEMTTPRQDPVIWSAPGAPGPIAAKDLQGYEHDGFLTVDQLITPDEVAVYEAELNRLITDPAIRADERSIVEKQSQNVRSVFEVHKISEVFAALVRDERVVGRARQILGSDVYVHQSRINVKPGFGATGFYWHSDFETWHAEDGLPNMRTVSVSIALTENFDTNGGLMIMPGSHKSFLGCAGETPKDNYKKSLQMQDAGTPSDEALTKMADRHGIRLFTGKAGSATWFDCNAMHGSGDNITPYARSNVFIVFNSVENEAQEPFAAPIRRPEFIGARDFTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z699</accession>
    <name>A0A7K2Z699_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">purD</name>
        <name evidence="9" type="ORF">GT040_00745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000023">
        <property type="protein sequence ID" value="MYW27833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="107"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW27833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="416" mass="42646" checksum="9561EB24FCBE866B" modified="2021-04-07" version="1">MKVLVIGGGAREHALCRSLSLDPDVTALYCAPGNAGIAEVAELHPVDALDGDAVARLAAELGAELVVVGPEAPLVAGVADAVRAAGIPCFGPSGEAAQLEGSKAFAKDVMAGAGVPTARSYVCTTPAEIDEALDAFGAPYVVKDDGLAAGKGVVVTDDLAAARDHALSCDRVVIEEFLDGPEVSLFAITDGTTVLPLQPAQDFKRALDGDAGPNTGGMGAYSPLPWADPKLVDEVLETVLQPTVDELRRRGTPFSGLLYAGLAITSRGVRVIEFNARFGDPETQVVLARLRTPLAGVLLASANGTLDVLPPLTWRDDAAVTVVIASHNYPDTPRTGDPIDGLAEVAAQDAPDAYVLHAGTRTEGGAVVSAGGRVLSVTATGKDLAAARERAYTALGRIRLDGSQHRTDIALKAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6I3</accession>
    <name>A0A7K2Z6I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_01380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000060">
        <property type="protein sequence ID" value="MYW27957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW27957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="296" mass="30502" checksum="4D04EAD926235C14" modified="2021-04-07" version="1">MTTFIELLLGGLSVGSVYALIALGFVVIFKATEVVNFAHASLLLAGGYVTAVLHDDIGFWPALLVGIAGAATVGAAIEFFVMRRYRGSDHSVLAIVTIGVDILLITELTRRMGTDVLALGDPWGNEVVNIGGITLAQTRIAAFLAAGLLITVFLLAFRYTSWGVSMRAAAENPQTAALMGIKLGRVSLAAWAVAGALAAVAALFLTVFPTPGLERATSLAALKAFPAAILGGLDSTTGALAGGLIVGVTESLATGYQSDLSFLGRGIGDLAPYLVMVAVLLIRPAGLFGTKELARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6R8</accession>
    <name>A0A7K2Z6R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/LC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000070">
        <property type="protein sequence ID" value="MYW28018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015607287.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000070.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="15205" checksum="5EA2DC9DAC9CDE10" modified="2021-04-07" version="1">MTAPNAAAPNPARHGSGELNWLLDELVQRVASIRKALVLSSDGLATGTSQDLTREDSEHLAAVASGFHSLAKGVGRHFDAGRVRQTVVELDEAFLFVTAAGDGSCLAVLADADSDVGQVAYEMTLMVKRVGAHLANAPRTTGLPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z720</accession>
    <name>A0A7K2Z720_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000105">
        <property type="protein sequence ID" value="MYW28146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="16324" checksum="D7FC833A4BF86515" modified="2021-04-07" version="1">MNAQTRPPDPSHQRPDGVTDTTVEALGALSKALETTERARGALYTFHQLTGGADLSLDDAVRLLREAGHGEQADRVRREILGRNVIPGHWTFQIVEEYNATYYDVFRTVEREIRGELADGRDHLYEAEMKEARRTREHPDHSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7A3</accession>
    <name>A0A7K2Z7A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000117">
        <property type="protein sequence ID" value="MYW28221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029864556" evidence="1">
        <location>
            <begin position="36"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="56"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="388" mass="42182" checksum="128806BDE5DCB237" modified="2021-04-07" version="1">MTERESGTPGRRALLGAAVLSTAALGLAGTAQAQAAERGRGGHGGGHGSLRDLPVPTVIGHRGASGYRPEHTLGSYQLALDLGAHIVEQDLVPTKDGHLVCRHENDITATTDVADHPEFAGRKATRKIDGVSYTGWFTEDFTLAELKTLRATERIPGNRPDNTLYDGRWTIPTFEEVLRWADQEGRKRKKPVWLYVETKHPTYFRSLGLGLEEPLARLLRRYGRDGRNAPLILQSFEPSSVQRLARLVDTPRIVLLSGPTSRPWDFVESGDPRTVADLVTPAGLKWIASYAQGIGPTLDLVIPKDAAGRLTTPTTLVKDAHARGLLLHPYTLRNENGFLPADFRRGTDPNAYGDVFGAAAAYFATGIDGIFSDHPDTALLAAADFDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7F0</accession>
    <name>A0A7K2Z7F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_03060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000144">
        <property type="protein sequence ID" value="MYW28279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029480788" evidence="3">
        <location>
            <begin position="24"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="22433" checksum="F682F8252E82659C" modified="2021-04-07" version="1" fragment="single">MLLLVLLGATALGAIGLSGSAIAADAMGAQVLGILLYASAPGVLCALLAWHLRTGGRRVRWGIVAVQVWLIVGGLGNLADGSPDGFTQLVLPVVILVLLSRAQSRAWFLLPPRERGEPPKFSLPYMITWKRDRGQSALEYLGLVLIVVALIAALTVGGLGGRITEGLQSAICSLTGSSCPVSGGSGEVEAGDTSGGTSGGASGGTDAGSTVTGGTGAPGGDATGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7K0</accession>
    <name>A0A7K2Z7K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="6508" checksum="69F038EAF06345BB" modified="2021-04-07" version="1">MSTIDAGEPSPEMAAVEADMQRVDLFRRAHALVNDLEWGDTVGVYDVLQVARFLEGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7T0</accession>
    <name>A0A7K2Z7T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000157">
        <property type="protein sequence ID" value="MYW28409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="221" mass="23946" checksum="9B39240CBE7BCC70" modified="2021-04-07" version="1">MSHTAGIRQTQKLKTRQALLDAALLLLEHQSLSSLGLREVTRAAGVTPTAFYRHFADTAALGVALVEETLGSLHGLIAAVLAETGDSQERVDRSVEVIARHVGAQPAHFRFIAREQHGGVGPVRAAIATQLRRFAEEVACALGQEPGSAGWSEEDLLMLGGLYVDHMVITTSTLLEAGPEGEAEVVRVARRRLRLVTIGRAHWLDEAPARDRERDEAPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z859</accession>
    <name>A0A7K2Z859_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mltG</name>
        <name evidence="9" type="ORF">GT040_04490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000200">
        <property type="protein sequence ID" value="MYW28547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="31263" checksum="C7B27ABC1AF534E1" modified="2021-04-07" version="1">MVNESPDARPRRRLRPTRRGKIVLVVTALLVVSAAVLIPLSLFGSDEQKEKKERPQSTLVIPEGWRASQVYTAVDRALGLKSGTTQKTAATVDLELPEQAEGNPEGYLFPATYPIDSATKPTGLLRYMADTARKRFGADHITAGAQRNNVTVYETATIASIVQAEADTASDMGKVARVVYNRLLKDMPLQMDSTINYALKRSTLDTTTTDTQLDSPYNSYVRKGLPPTPIGNPGEEALRAAISPTPGPWLYFVTVAPGDTRFTDSYDEQQRNVEEFNSNRRAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8I2</accession>
    <name>A0A7K2Z8I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000233">
        <property type="protein sequence ID" value="MYW28667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="221" mass="23201" checksum="F6EEC458F9D1CC52" modified="2021-04-07" version="1">LTLGKGHATLTPLGNWAVWVKLEQICVAAQSPAGNIEQSAADMLLGCARLTPGPARAEYRAWLAARTVGSAVAELLAVARGEDALLRGLAFEALRVVGAPAEPEVRAVVTNPSLRPYALLWLAEYEGADPDDAQEILSREEATWLWVDTAAAVADHGETGLLVRHLDSAVQGTVPALLDEVRAVGHPRTVQVLVALAAAHPDPALAKAVRRAAFQVHTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Z1</accession>
    <name>A0A7K2Z8Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000255">
        <property type="protein sequence ID" value="MYW28796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="168" mass="17933" checksum="AE0359A0F1E0E39D" modified="2021-04-07" version="1" fragment="single">MGRVSQAQAEENRRRVVETASRLFREQGTHVSVADLMKAAGLTHGGFYKQFASKEALVDEATAHAFDGFARLREDGLERHAGQRDAAQRALISTYLSAEHRDSAADGCPAAGLASDMARASGSDTAHRVYAEGVADFARWLATEDEDGLARLSTLVGALVLARATKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z941</accession>
    <name>A0A7K2Z941_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000271">
        <property type="protein sequence ID" value="MYW28864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="145" mass="14931" checksum="B48014B1FFB9B57A" modified="2021-04-07" version="1" fragment="single">MTAADPLRHALAQELPATTVLDAAGALRLTEGSAVVILDAWTLGTAEELSRHALAHPVTLVPVRGDGALTVAGPVLRPGARGCLACGEYRRLATIGGRVPWHSPGLRLEGRPSPAFTDAVGVLAASLLDSDGAVVHVVHNGRGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9V0</accession>
    <name>A0A7K2Z9V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Primosome assembly protein PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000350">
        <property type="protein sequence ID" value="MYW29113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="91" mass="9310" checksum="CF49012B001FB10F" modified="2021-04-07" version="1" fragment="single">ESKPSPEPLPPPPPPEPGTWERYGQGPAFLRALAEGGAPRAVWTALPGPHWSAEIARAVAATLSSGRGALVVVPDGRVAGRVDAALTEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9X2</accession>
    <name>A0A7K2Z9X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_07380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000339">
        <property type="protein sequence ID" value="MYW29102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="91"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="239" mass="25515" checksum="80BB90E62BD81BA9" modified="2021-04-07" version="1">MSNDQPTPGQPPEDDDPFVKKPQEPPPPSDGQPPYGQPPSGGQPPYGQPPSGGQPPYGSAPPPPPPPPNDPYGSGGGFGAPDPLAGMPPLAEPGKRILARLIDFLIISIPLYLISLPWGGAIDVGGDGGDGFDGAYSGHQFLWSFIGLVVYVAYDTYFTHKDGRTLGKRLLKLRVAMLNDGRVPDTRAALMRAVVLWAPALLCCPCLWWLINIVLMFTDKPYRQGLQDKAAKTVVVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAG2</accession>
    <name>A0A7K2ZAG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="15169" checksum="C5968EC77A46E3A1" modified="2021-04-07" version="1">MPVTAEPDPPDYRQDLVAHPESLAIMRRIVSAHVDLWGFRELADSVTLCAHELLANVDRHTGSPHCTITLRRRPNGVRVTVTDTNTDPLESSDPDWDAESGRGLALINGVAEHFGTVIRRDGKDVWAEILTSRPAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAN7</accession>
    <name>A0A7K2ZAN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000410">
        <property type="protein sequence ID" value="MYW29399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="21947" checksum="2586D59E6E98A64B" modified="2021-04-07" version="1">MKEHDRDDPELDAVLTGVGPRLRRLRKDRGVTLSELSAATGISVSTLSRLESGGRRPSLELLLPIARAHEVPLDDLVGAPPVGDPRVRAKPIVQHGRTMLPLTARPGGLQAYKMVQEAGSGEVPEQRTHEGYEWLFVLSGKLRLLLAEHDLVLEPGEAAEFDTRLPHWFGPAEDKPVEFLSLFGPQGERMHVRAKPKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAR4</accession>
    <name>A0A7K2ZAR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Betaine/proline/choline family ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_09065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000413">
        <property type="protein sequence ID" value="MYW29423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="423" mass="46711" checksum="58ABA125225B862E" modified="2021-04-07" version="1">MPETETDPAVATEDGNTATSGATIELESLTKRYPGNPNPAVENVSMEIKAGETVIFVGPSGCGKSTTLKMINRLIEPTSGRIRIGDEDVTDIDPVKLRRKIGYAIQSSGLFPHMTVADNIALVPKMVGWSKSRVKDRVEEMLDLVGLDPREFHGRYPRQLSGGQQQRVGVARALAADPPVLLMDEPFGAVDPITRDHLQDELIRLQHELHKTIVFVTHDFDEAIKLGDRIAVLRERSHIAQFDTPEAILTNPTDDFVSGFVGAGAALKRLNLTRVRDVGIADFPTVTVEDPLQTIFNKLRNGPHNELLMLDRQNRPYKWLRRGDLMRARGSLARAGQLVHDTVTRDATLHDALEAVLTDSGGRVAVTGRRGEFIGVVDMKTLMDNVQELLEADRLTAMEHQHELEEQRVHQTEQELEGGGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB74</accession>
    <name>A0A7K2ZB74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">nirB</name>
        <name evidence="18" type="ORF">GT040_09925</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000457">
        <property type="protein sequence ID" value="MYW29584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="7 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="14"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="17">
        <location>
            <begin position="331"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="15">
        <location>
            <begin position="430"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="14">
        <location>
            <begin position="565"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="13">
        <location>
            <begin position="637"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MYW29584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="857" mass="90396" checksum="075A69EC5DBD2ABE" modified="2021-04-07" version="1">MPDTTIPNTTPTFVLVGHGMVGQRFLESLAARGLTPAAGRARIVVLCEEPRPAYDRVQLSSYFAGRTPEELSLVEPEFMAEHGIELYVGDPAESVDRTARTVTARSGAVFPYDALVLATGSYPFVPPVPGKDSRGCFVYRTIEDLLAIEEYAKGAGTGAVVGGGLLGLEAAGALKGLGLRTHVVEFAPRLMPVQVDEGGGAALLRTIEGMGLTVHTGVGTQAVTAGTDGAVNGMALSDGSSLATDLVVFSAGVRPRDRLARDCGIAVGERGGIVVDEECRTSDPAVFAIGECALASDGRVYGLVAPGYEMAETVAEVLGGGRAGFTGADMSTKLKLLGVDVASFGDAHGSAEGALDVVYADSRSGVYKKLVVGADGTLLGGVLVGDADDYGTLRPLTGSVLPVSPEQLVLPAGAGGPVTLGPSALPDDAVICSCHNVTKGAIREHPTLPEVKKCTRAGTGCGSCVKVIGQLLPQSLDTGLCGCFAYSRSELYEIVRTLGITSFTVLLDSHGREEARGGEGCEVCKPTVGSVIASLAPTLGASGYVLDGEQASLQDTNDHFLANLQRNGSYSVVPRIPGGEITPEKLIVIGEVARDFGLYTKITGGQRIDLFGARVDQLPLIWARLVDAGFESGHAYGKSLRTVKSCVGQTWCRYGVQDSVRMAIALELRYRGLRSPHKLKSAVSGCARECAEARGKDFGIIATAGGWNLYVGGNGGATPRHADLLAQDLSDAELVRLIDRFLMFYIRTADRLERTSAWLERIDGGLEHVREVVVHDSLGLCDELERLMADHVNGYRDEWAETIDDPERLRRFVTFVNAPDTPDPSVKFVPERDQVKPDLELLAGPVLAVRTLEGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB83</accession>
    <name>A0A7K2ZB83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-aminoethylphosphonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000454">
        <property type="protein sequence ID" value="MYW29568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029638106" evidence="2">
        <location>
            <begin position="32"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="354" mass="37975" checksum="4C609AC1A0765F74" modified="2021-04-07" version="1">MRTHALNRPLAVLGALSLAALTLTACGGTSAASDEKVVTVYSADGLKGENGDGWYDKVFKEFEKETGIKVKYVEGGSGEMVQRTVREKSNTQADVLVTLPPFIQQADEKGLLAAYEPKGADQVDAADKAPDAKWTSVVNNYFGFIYNKQRLTTPPRTWEELLDASYKEKVQYSTPGVAGDGTAVLIKAMHDFGGKEPAMEYLKRLQTNNVGPSASTGKLAPKVDKGELLVANGDVQMNYAQSKDMPNLAIWFPAKGGGKPTSFALPYAAGLLAKAPHSENGKKLLDFLLSEKAQRDVSAVGGGFTARKDIKATDANATELNGLLEGVEIFEPDWSDIGANLDTYIDVWKTATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB88</accession>
    <name>A0A7K2ZB88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Threonine/serine exporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_10000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000459">
        <property type="protein sequence ID" value="MYW29599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="7">
        <location>
            <begin position="146"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="8">
        <location>
            <begin position="413"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="567" mass="59159" checksum="42F1F00C2F5B1A6B" modified="2021-04-07" version="1">MVAESGGPEDQKPQSDEARSAFVPPAGTMQPVSPPEEDHPTSEFAIPTGVHPETSGSGGSGGGSTGGPNSDTLSSAFTPPSSYNAQQAPPAFTPAQGIPMVKLTKEAPWQDRMRTMLRMPVTERPAAESIQRTDDDTGPAVPRVLDLTLRIGELLLAGGEGAEDVEAAMFAVTRSYGLDRSEPTVTFTLLSISHQPSLVDDPVTASRTVRRRGTDYTRLAAVFRLVDDITSEDAEVSLEEAYRRLAEIRRNRHPYPGWVLTAAAGLLAGSASVLVGGGPLVFLVAAAGAMLGDRLAWLCAGRGLPEFYQFTVAAMPPAAMGVALTLTHSTDIRPSAVITGGLFALLPGRALVAGVQDGLTGYYITASARLLEVMYFFIGIVAGVLIVLYLGLQLGAQLNPEARFVAYNEPVVQILASMALSLAFAVLLQQERSTVLAVTLNGGVAWIIFAAMARTGEISPVAATAVAAGLVGLFGQLFSRYRFTSSLPYITAAIGPLLPGSATYFGLLGVAQNELDTGLASLSTAVATALAIAIGVNLGSEISRLFMGVPGAVGGASRRAAKRTRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBQ6</accession>
    <name>A0A7K2ZBQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex cytochrome c subunit</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GT040_11030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">Binds 2 heme groups covalently per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000499">
        <property type="protein sequence ID" value="MYW29801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009152">
        <property type="entry name" value="bc1_cytC-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000007">
        <property type="entry name" value="Ubiq_cycred_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="115"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW29801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="24651" checksum="49FA21F6B6FED6CE" modified="2021-04-07" version="1">LYAAFAPAGKAQADETAQSLAIDEGKKLYTVGCASCHGTGGQGTTDGPSLVGVGSAAVDFQVGTGRMPAQQPGAQVPKKKVIYAQAEIDQLAAYVASLGAGPIKPTDKQVDPAGADVAKGGELFRNNCAQCHNFTGKGGALTKGKYAPDLEGVSPKHIYEAMQTGPQSMPSFPDTTMPEQEKKDIIAYIQTVNGSETASPGGLSLGGLGPVSEGLFAWIFGLGALVATAVWVAAHTAKAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBU9</accession>
    <name>A0A7K2ZBU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="13" type="ORF">GT040_11250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000507">
        <property type="protein sequence ID" value="MYW29841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="12">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="9">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="9">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW29841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="22990" checksum="274AE95C791F64AD" modified="2021-04-07" version="1">MPTPREQLSDARLYLCTDARKRQGDLPAFLDAVLAGGVDIVQLRDKGMEAAEELEHLAVFADACRRHGKLLAVNDRADVAHAIGADVLHLGQGDLPVPAARAIIGSDRLIGRSTHAESEVDAAVAQEGVDYFCTGPCWPTPTKPGRHAPGLDLVRYAASLRQSRPWFAIGGIDAGNLDEVLEAGARRIVVVRAITAANDPAAATAELAKRVRAHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBW0</accession>
    <name>A0A7K2ZBW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000510">
        <property type="protein sequence ID" value="MYW29851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029442163" evidence="1">
        <location>
            <begin position="35"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="72"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="325" mass="34310" checksum="959CBBA69AD398EC" modified="2021-04-07" version="1">MTRTALRVRRWAAIAVLGGLLAGCGTTGGESGTAAEPATGPRTSTEVQPIKAATEITDAKGVTVSLKKPPQKIVCLVALCDDILVELGMTPTATNSAVLAHPEFLGKEKAAKVPVVPGGFLSPEVEAILSHRPDLVIGLEDTHGKLAPALKGATTFWPVQPGSWKDSVGYLRDLAALTGRTEEGEKAEKTFRARLAKAEEARSDKTALIIFGSDENFGVATPETDVAAGLLPKISHYPWKSRGVDGSYSLEEILARDVDVLFVETLAFGAPDGKLSDKLAKSPLWSRIPAVKNGKVIEVDSEVWAKGRGTRSLGVVLDEATAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC39</accession>
    <name>A0A7K2ZC39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BatC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000544">
        <property type="protein sequence ID" value="MYW29917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="6165" checksum="30A7D135E6D60CC5" modified="2021-04-07" version="1">VHDGGADGGADGGAEGPADGGAAGTPGVHDGGADGGADGGAEGPADGGAAGTPGVHDGGADGGADGGAGQSGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC48</accession>
    <name>A0A7K2ZC48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000546">
        <property type="protein sequence ID" value="MYW29941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="16859" checksum="06B0D4BE7DED8219" modified="2021-04-07" version="1">MNRIGITGHRSIPDGARTHVLAGLRAALCGLDGATEALSSLAVGADQLFAGLALDCGAKLTVVIPSGDYEACFESTAELARYRLLKSRAAQEVRLDFPHSTDEAYYAAGAYIADHCDLLLAVWDGRPARGLGGTGDIVDYARTLGRPVTVIWREGVERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC86</accession>
    <name>A0A7K2ZC86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000548">
        <property type="protein sequence ID" value="MYW29970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="362" mass="39921" checksum="9E122A83DB5A7100" modified="2021-04-07" version="1">AVRDFGDRPQDLAPEVADEAERRLRGLRRPNMVPYTQSAERQNPFVGSGDKIKETVWQPIDISRPADAPGGGKASLVPFDAVDLHTYLARELGNLAGLEGLRAQNRLYVLGPRVLYLGDDVLPDRLRPPNSEIPPPLVKAGLLKPGAGMRTYLSLERVGEGGRVIVSMHLRARLQHPSLSWEVAAYCIPPLHARYYGADYLPRDGFEHWWSLVRYATSHTWSGLAGAPGRIGRRNAEHKRRARELEKARKEITKKHALYDYGTTDSLRERVGSGDQLGHSERTDSQDFLHRLQQGVLIATERFLKDHNVDTSSFDQAQQVINTQTYNISGDITGPANIGNNGQVSAAYGQGAQATAAAGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCE6</accession>
    <name>A0A7K2ZCE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3068 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000556">
        <property type="protein sequence ID" value="MYW30009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="38577" checksum="EEB358BA9D362D35" modified="2021-04-07" version="1">MRRRAGLVLLAFAVFFAALSPLLRWYTFPRLAKVPPNQYQEVVLEAKPATLLDYTTLKAKEVEKVTIVQTLKGNVEESEKIERSAGRDVVVWDALSYIEGPDGKMVSEIPERYIFDAHTQAPVNATGEMVDGDPVRRTGIEFKWPFLTEKRDYEYFDAQSRTTAPIHYKGTRTFRGLEVYYFEQTIPWTKVPMPKKMPIEGVTAEQIAQTGMTRWYTTKRMFWVEPVTGAPVNGEEVHEEELRNAKKMGMSEDTVTAFSGHVKMREDYIVDTVDLVKSQRVLVLLLTSYLPWGFLGLGIGLLALALWLEARSRRPAATESSTVPESPPVPESPTAPESPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCT6</accession>
    <name>A0A7K2ZCT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MarP family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_13065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000606">
        <property type="protein sequence ID" value="MYW30191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="401" mass="42518" checksum="EC8466E182882002" modified="2021-04-07" version="1">MNVLDILLLLAAVWFAVIGYRQGFVVGILSVIGFLGGGLVAVYLLPIIWDRVTEGAEVSTATAIGAVVIVIVCASIGQAFTTHLGNKLRRHITWSPARALDATGGALVNVVAMLLVAWLIALPLARTSLPTLGKEVRNSSVLLGISRVMPQQPPPWFQDFSSVLAQNGFPQVFSPFANEPITEVKPPDPALVGSPVAARAKKSIVKVVGTAPSCGKVLEGTGFVFSGRRVMTNAHVVGGVSEPTVQIGGEGRLYDAKVVLYDWQRDIAVLDVPDLRATPLEFTGPNDDAQSGDSAIVAGFPENGAYDVRSARVRARIDANGPDIYQRGTVLRDVYSLYATVRQGNSGGPLLTPDGKVYGVVFAKSLDDPDTGYALTADEIREDIEIGRTANQQVDSQGCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCT9</accession>
    <name>A0A7K2ZCT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_12865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000600">
        <property type="protein sequence ID" value="MYW30153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="28"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="500" mass="51322" checksum="D47170948F80E2D4" modified="2021-04-07" version="1">MAESAARSGPAGRGAGPGGEPDPRRWKALAVCLVAGFMTLLDVSIVNVALPSIKEGLNTPESDLQWVLSGYALAFGLFLIPAGRLGDARGRRAVFMAGLALFTLASAACGAAQSSMWLVIARLVQGIAGGLISPQISALIQQMFSGRERGRAFGMFGTVVGISTAVGPLLGGLLIQAAGPDHGWRWVFYVNLPLGVVCLLLARRLLPDTPSAGRVRPRDLDPVGVLLLGAGVLALLLPFVQAQQWPGNGKWLLVVLAAALLGAFVAWEARCTGGPTHPVLDLALFRLRSYWLGCLLILLYFAGFTSIFFITTLYLQSGLHYSALQAGLAITPFALGSGAAASIGGRLVGRFGRPLVAAGLTMVALGLAGTALAVHLVPGSGAGWAMAAPLLLAGLGSGLVIAPNQTLTLAEVPVPRAGSAGGTLQTGQRVGSAIGIAAVGAVFFAQVGPEGWADAYDHGLIVSVAFVLAALIVALADVGADRRGRRRAESKSTDPPRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDA0</accession>
    <name>A0A7K2ZDA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobalamin biosynthesis protein CobG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000644">
        <property type="protein sequence ID" value="MYW30288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="7728" checksum="DD391EE4718B2C06" modified="2021-04-07" version="1" fragment="single">QLRGLGTECGGELAGLLTAAGLLPSAAHERARNIVASPLAGLDGSLSLGPWLTELDRLVCGSPAAAALSGRFLFALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDB3</accession>
    <name>A0A7K2ZDB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000651">
        <property type="protein sequence ID" value="MYW30298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030565003.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000651.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="15206" checksum="6E9FFFF8F70EF8E4" modified="2021-04-07" version="1">MATVELRFSAQPEHVRTARLVAAAVARRAGVDEAVLDEVRLAVGEACSRAVGLHRSHGITAPVSVVLTEEEKAFSIEVGDGVPDPGSDPATPGARGGASGGPDEPEGDGGEDEMGLAVISGLVDDVEVRSGADGGTIRMSWPTALAGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDG7</accession>
    <name>A0A7K2ZDG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ORF">GT040_13710</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="WWKE01000652">
        <property type="protein sequence ID" value="MYW30315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="185"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="377"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="192"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW30315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="497" mass="51778" checksum="3088D23DE3A41666" modified="2021-04-07" version="1">MSLLVVGLSHRSAPVSVLERASLAADTQAKLLQDTLAAEPATEAAVLATCNRIELYADVDKFHAGVAELSTLLAQHSGVGLDELTPYLYVHYEDRAVHHLFSVACGLDSMVVGEGQILGQIKDALARGQELHTAGRLLNDLFQQALRVGKRAHSETGIDRAGQSLVSFGLQQLAAGADPGLWARGKRALVIGAGSMSSLAAATLARTGVAEIVVANRTRSRADRLVEILQQGDDTTVRAHAVEMSAVGDELTRADVVVSCTGSTGLVLTADALADALGVTLDAPAEAPAATAVPAPADVDQHAAWVENGSATSAPGAPRRITLPAQSTGPVKLALLDLAMPRDIDGAAHRIDGVRLVDIESLADASADAPMAADVDQVRTIVADEVAAFGAAQRAAHVAPTVVALRTMAADVVAGEIARLDGRLPDLDEKQRAEITQTVRRVVDKLLHAPTVRVKQLASEPGGAGYADALRELFDLDPQTVAAVSRADLNDPNRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDQ8</accession>
    <name>A0A7K2ZDQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Non-ribosomal peptide synthetase condensation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000686">
        <property type="protein sequence ID" value="MYW30484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="276" mass="29226" checksum="CFDB5A3AC1BA5829" modified="2021-04-07" version="1">GRRRGAAALAHWEAGYRAAPATMFPEPVAAPRTPRFWTGRIVSPALARAVAAVATAHRVSGSTVLLTAAAVLVAAGQGHRTAAVMPIVGNRTAAGHRDLVTTLSQDGLFVLDLAAAGTPEPSFTDLLPAAYRSALRSYRAAVYDPVEWDALGERMRTERGAEVHPYCCFNDMRLVERPAPPGPAPTAGELAELGGRTVFGFPATQERVACRYCLHITEEGDALAVSLTADTAYLPPETIRAHLYGIEELIVRAAAGRSPLLAGVRELLETAGKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE02</accession>
    <name>A0A7K2ZE02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OB-fold tRNA/helicase-type nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000715">
        <property type="protein sequence ID" value="MYW30552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016499">
        <property type="entry name" value="NucleicA-bd_Rv2694c_prd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006910">
        <property type="entry name" value="NA_bind_Rv2694c_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="15424" checksum="B6A89688DA84A711" modified="2021-04-07" version="1">MSAVPRHEKAGRAERPSGRFRRMLDRLSSSQEDLESQELREDTQATGCTRISECSDRQIVKVAGTLRTVTLRPRAGVPALEAELFDGTEPLDVVWLGRRSIVGIEPGRRIIASGRVAMSHGRRVLFNPTYELRPLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEI7</accession>
    <name>A0A7K2ZEI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_16205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000759">
        <property type="protein sequence ID" value="MYW30777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="235" mass="26354" checksum="C1D4F7AA8FB20C45" modified="2021-04-07" version="1">MVAEDDEKQAELVRRYLEREGHAVRIVGDGLAALDAVRRQEPDLLVLDVMMPRADGLDVVRVLRAEARELPVLMLTARTAEDDLLLGLDLGADDYMTKPYSPRELMARVRTLLRRTRRPGGAASAPDDHVLRVGGLVVDPERHEVTVDGEPVECTRGEFRILAALAAGPDRVFSRQRLLEELHGFDRYISDRTVDVHVMNLRKKIEPAPRRPVRLLTVFGVGYKLTDPAKAARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEW5</accession>
    <name>A0A7K2ZEW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SigB/SigF/SigG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_16895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000788">
        <property type="protein sequence ID" value="MYW30907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513654.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000788.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="31591" checksum="BBF80645BF6779D2" modified="2021-04-07" version="1">MSAEQGSSKVLTLTKSVPAPAVLTSSPEAIDTRTLSRSLFLRLAALGPASGPEGTDSPERTYVRDTLIELNLPLVRYAAARFRSRNEPMEDIVQVGTIGLIKAIDRFDCERGVEFPTFAMPTVVGEIKRFFRDTSWSVRVPRRLQELRLALTKTSDELAQRLDRSPTVPELAKALGVSEEDVVDGLAVGNAYTASSLDSPSPEDDGGEGSLADRLGYEDAALEGVEYRESLKPLLAKLAPRERQIIMLRFFANMTQSQIGEEVGISQMHVSRLLTRTLAQLREGLISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFA3</accession>
    <name>A0A7K2ZFA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000808">
        <property type="protein sequence ID" value="MYW30965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26258" checksum="5FD760DED25AF8ED" modified="2021-04-07" version="1">MTITEQPFHGWSPEAVVFDCDGTLMDTEQHWQDARGRAFRDFGLRPAPGFAERAKGVHYLDCGRMMAEEADKPDLAPELTESLLAHFMERVADDPVTMPGAAEFVRNLSGRLPLAVASNCPLAVVERSLEQAGLLSHFGHIVVPGDPESTGAATRSPDGREPIRPKPWPDVYATAARLCGARSERTLAVEDSFTGIVSARRAGLRVVGVGKPPGDGRESTVDLWVPTLHAPELLDLDWVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFG1</accession>
    <name>A0A7K2ZFG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_17565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000820">
        <property type="protein sequence ID" value="MYW31039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="9277" checksum="1BBD51965075205F" modified="2021-04-07" version="1">QWRQELRPGWTGLAQVRARSGMPWDDPALLDQHYAEHHGVVLDLAILAEAVRTPLRAALGKARSTKAHLSDTDHRPSGYSRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFK2</accession>
    <name>A0A7K2ZFK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">folD</name>
        <name evidence="11" type="ORF">GT040_17950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01000855">
        <property type="protein sequence ID" value="MYW31110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="9">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="10">
        <location>
            <begin position="131"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW31110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="29961" checksum="DDE675E44DE7B3B6" modified="2021-04-07" version="1">MSQTQTARLMDGVGLARRIVEETSSKATELARRVGVTPCLATVLVGEDPASVTYVRMKRARCAKAGIESRLVSLPATTTTAELVETIQSLSQDAGVHGILLQHPVGPHIDERAAFEAIAPEKDVDGVTMSSFGAMSFGLPGFASCTPGGIMRLLDEYGVELAGQHAVVVGRSAILGKPVGMLLLARDATVTYCHSRTTDLAAIVQEADVVVAAVGRPRLLRGEDVKPGAVVIDAGYNPGNVGDVDFDTARTRARLITPVPGGVGPMTIAVLLAQTVDAASIQLGLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFR4</accession>
    <name>A0A7K2ZFR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MCE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_18275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029482146" evidence="2">
        <location>
            <begin position="20"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="114"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="379" mass="39574" checksum="533DCBEFADAD0C24" modified="2021-04-07" version="1">MRRIRIIGIGAGLAVVAVAATTGVSALQEDSRTTVTAYFERATGVYAGSDLRILGVRVGTVESVTPRGREVKVVLRLDRGVKVPKDAHAVVVAPSLVADRYIQLAPAYDGGPLLADGAQLPAARNATPVEVDQLYASITEITTALGPNGANADGALARLLETGAKNMDGNGKAIGDSVEQFGKAAKTLDRSSGDLFDTLAYLQSFTTMLKENDSEVRTAEQQLNSVTSFLADDKKNLSAALKELGAALGQVKTFIAKNRGALKKNVDALVPITQALVDQRASLAEAMDTLPLAAGNVLNAYDPANRTLNGRANLNELSMGGPLVDPDAASGPPPGLAPVDANRRKALPVLPLPEVGTVFGTPEKQPAQRKPDDRKGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG40</accession>
    <name>A0A7K2ZG40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional metallophosphatase/5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_18750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000871">
        <property type="protein sequence ID" value="MYW31259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07412">
        <property type="entry name" value="MPP_YhcR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041831">
        <property type="entry name" value="YhcR_MPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029946929" evidence="1">
        <location>
            <begin position="36"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="62"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="4">
        <location>
            <begin position="412"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="607" mass="63234" checksum="AF8D76F6D7D06E61" modified="2021-04-07" version="1">MSATPQKKRASRRVLAAAAGLATVGALVAAMPAGAQDRGHGHGHGHGHGHKPRTVDVQLLSFNDLHGNLEPPAGSAGNVSETQPDGTVKAIPAGGVEYLATSLRTARKGNPYSVTAAGGDMVGASPLLSGLFHDEPTIEALNKLKLDVTSVGNHEFDEGATELARLQNGGCHPVEGCYEKGKKFKGADFPYLAANVTKEKTGKPLLKPYTVWKKNGVKIGFIGVTLEGTPDIVTANGVKGLKFHDEVETINKYARELDRKGVKSIVALIHEGGAPASTSYNYDCDSPGPGSGISGPILDIAKGITPKVDALVTGHTHQAYVCTVPDPAGKPRMVTSASSFGKLYTDTTLTYDRRTDDIVRTSVKSANHVVTRDQPKAADMTSLIERWNKLAAPIANRPQGWISADINGRGSTAPEKPLGNVIADAQLEGLAPADKGGAEVAFMNPGGIRADLVHKASGSEGDGVVTYGEAFTVQPFTNMMNVVDLTGAQLVTALQQQVSGPNEASPKILQVSKGLTYTLDLTKTGAARVVTDSIKLNGAAIDPARTYRVAMNEFLAGGGDGFPALGQGTNKLVGASDLDLFNAYLAAHSTAAAPLAPPATDRITVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGB2</accession>
    <name>A0A7K2ZGB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="12909" checksum="46BA4184866F8AD9" modified="2021-04-07" version="1">MTRGRAQDPNVCGVTAAIAVVDGKWKSGLIWLLESGPRRPGELRRELPGLSEKVLTQALREMEADGLVRREVHDVRPLKTTYSLTEDGQELAGLLDTLSDWGRRRLARLTELQSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGC9</accession>
    <name>A0A7K2ZGC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000912">
        <property type="protein sequence ID" value="MYW31407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030567311.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000912.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="14070" checksum="4B9238CA76FC2056" modified="2021-04-07" version="1">MAKSPVEITTQLSMAEAADVFREAMRVSWWSEHVTGAGTTFEQPSGSVFDTVAEDRPDFVVMALLGGRGAGIQKSAVHMYMWNRGPNREIMLGVGRNLGSFGIKANRKIRRYVDALADLDPSMEYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGL2</accession>
    <name>A0A7K2ZGL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000927">
        <property type="protein sequence ID" value="MYW31476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="525" mass="55828" checksum="53909F18E9FAA78F" modified="2021-04-07" version="1" fragment="single">MAPAIPPPPRPPQNTGAALELLVHGVGGATPQEMLGDPRTVRVTGDATAAVYRRTEDAHGEKHPERYRDEPVAEAYCWSGLTSGNGSRALWLLLLPFMVVNLAHWMRPTAAGRTRAVRLYGVAVRLVALSLTVLLTAAACEVALDLVAWQCAGTSACSERRSWLGFLSSTQGGWWSQPGRRLALAAVVPAALVGLLWYLSNRTWSAYESQSPLDVTDDDACDPDGTEEAHGPGAPDNADDPESARPVPPALSRPGFWYGRRLVSRLRAAHTAAGFLTVAAFVMGAATLHDRTVGGSVPPVFGLVIQGALVLCAVVVVWVVCRRGRSESVRDNRVDGALITYLPGSALTLLGLAVVHAAWSRPEWVSSGSLSGETAFRLLALGQGLLVVTMALVARSLYRRTPEPRTTLYGLGGPSVAMLACALGGVMTGGVAQRVADWLDGPGTPGMGRGSIIEGPPVLLSWQASVIPVLLLLLLVPVLFLTVRTARRARRMGPDIEAEYAPEPPDRARTRRIARIRATASLTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGL6</accession>
    <name>A0A7K2ZGL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000916">
        <property type="protein sequence ID" value="MYW31429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029797313" evidence="2">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="13533" checksum="3F38FBE3C057B6AE" modified="2021-04-07" version="1">MKKMMAGAAVAVSLLGLSAVAAPTAMAIGNDGGTTTVNGNGAESEIGNAETKGDWSPQNQLVQGTLNKLCVGLPAKVNVGSLIGLVPVTVQDINVLSNPQNQQCTDNSTQAKGDEPLSHILDGIPVLSGNGVGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGN6</accession>
    <name>A0A7K2ZGN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YihY/virulence factor BrkB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_20095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000936">
        <property type="protein sequence ID" value="MYW31514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="370" mass="39925" checksum="C94FD682F1A4ED4A" modified="2021-04-07" version="1">MAWQLLKDTVNSCIEYRILGLAAEAAFFTLLSLPPLLLGMIGLLGYVDEWTATTTVASIERNILSASQTVLSERGVNDFAKPLLADVTTGARPDVISIGFAIALWSGSRAVNVFIDTITVMYGLDGHRGIVKTRLLAFLLYVVALLLGAVVLPLLVVGPDRVVEFVPWGTEVIAVLYWPLVILLTIAFLTTLYHVSVPVRSPWIEDVPGALVALGMWVLGSFLLRIYLTNTVEGPTIYGSLAAPIAVLLWIGISAFAVLVGAAVNAAIDHVWPSLATAAAREATERVRAAQAAEFVARTRPATYDGADDDEDEDDGPAYMPSEFPERWSRFLPPDDVKSRLQSTWEKEPKGGKAGKEPGHSTNDSGPQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGP2</accession>
    <name>A0A7K2ZGP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_20085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000935">
        <property type="protein sequence ID" value="MYW31512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029909250" evidence="6">
        <location>
            <begin position="48"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="44"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="21912" checksum="1D5726AE26E33A2B" modified="2021-04-07" version="1" fragment="single">MRTEPRWHRTRSTRSITPNKRSKVLAGATALLLPLAAMVGLASPAEAAASATATYTKASDWGSGFEGKWTVKNTGTTTLTSWTVEWDFPANTKVTSAWDATVTNSANHWTAKNLGWNGTLAPGASASFGFNGSGSGAPSGCKLNGNPCDGGPTVPGDNAPSAPGKPTASDITNTSVKLSWAAATDDKGIKNYDVKRDGATVATVTGTTYTNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGY8</accession>
    <name>A0A7K2ZGY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_20660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000973">
        <property type="protein sequence ID" value="MYW31623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030570949.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000973.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="222" mass="23948" checksum="45CB6104D820503D" modified="2021-04-07" version="1">MSDTDIRVLIVDDQMMVREGFSVLLNAMPGITVVGEAVDGRQAVAQVAALRPDVVLMDIRMPEMNGIEATREIVAQDADAKVLVLTTFDLDEYVYQALRAGASGFLLKDASARQLADGVRVVASGEALLAPTVTRRLITEFSKLAETPRPPALARIGDLTERETEVLVLIAQGLSNAEIASHLIVAESTIKTHVSRILVKLGLRDRTQAAVFAYEARLVTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH60</accession>
    <name>A0A7K2ZH60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000985">
        <property type="protein sequence ID" value="MYW31686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="261"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="36258" checksum="BBEA6C744B87F1E9" modified="2021-04-07" version="1">MLGALGLDERQEAAYRALVAAGAAELSDLAHRLSLPEADAERVLRRLEQQGLAAQSSARPGRWVAAPPGVALGALLIQQRHELEQAELASALLAAEYRAEASEPEVHDLVEVVTGSAAVAQRFHQLQLGAATEVCALVTGKPIAVTGLENESEERAASRGVAYRVVVEREVLSLPSGILELSAALSRDEQCRVVDRVPTKLVIADGTTAMVPLTGRGAEPAALVVHASGLLESLMGLFEAVWREAMPLRLGERDGSVREDGTGPDPTDLEILSLLLAGLTDASVAKQLELGLRTVQRRVKGLMELTGVSTRLQLGWHAYERGWVARSAQPGSPPSAQVAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH95</accession>
    <name>A0A7K2ZH95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3291 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001003">
        <property type="protein sequence ID" value="MYW31722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11531" checksum="00F73F2F5423ED47" modified="2021-04-07" version="1" fragment="single">MTSIDTETDFAQHELAQVNIARLRFPLDSTELKEFVDGLDPVNAVADQAEGFVWRLRSESGNATDVPVFGDAWLIVNMSVWRDAEALTGFMYAGRHRELMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHF9</accession>
    <name>A0A7K2ZHF9_9ACTN</name>
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        <submittedName>
            <fullName evidence="6">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_21490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MYW31780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="370" mass="39600" checksum="B3AED785E9F593DD" modified="2021-04-07" version="1">MTAAGKHQVSRTETPRRSGRPGRAGIRDVAAAAGVSITTVSDALNGKGRLPDATRSHVREVAERLGYRPSAAARTLRTGKSGLIGLTVTTYGDEPFTFTEFAYFAEMARAATSAALARGYALVILPATSRHDVWSNVALDGTVVIDPSDQDPVVTELVRQGLPVVSDGRPAGTLPVTAWVDNDHRAAVLDLLDHLAAAGARRIGLLTGTTTDTYTRLSTTAYLHWCERVGQDPVYESYPAHDPCAGAVAADRLLARPDRPDAVYGLFDPNGTDLLAAARRYGLRVPEDLLLVCCSESTVYAATEPPITTLSLKPRRIGTAVVQLLIDAIEGVEHDGPVEQVIPTELIIRTSSQRRPPRTTVSPPRSPSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHG3</accession>
    <name>A0A7K2ZHG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thiol reductant ABC exporter subunit CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cydD</name>
        <name evidence="10" type="ORF">GT040_21510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014216">
        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02857">
        <property type="entry name" value="CydD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="333"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW31784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="549" mass="58595" checksum="679D556220FEC593" modified="2021-04-07" version="1" fragment="single">MKPIDPRLLRYARATRFFLAAVVGLGLVGAALVIAQAMLIAEIVVGGFEDGLTVTELRAPLLLLAAVAVGRALVAWLTELAAHRASAAVKSELRGRLLERAALLGPGWLSGQRTGSLVALATRGVDALDDYFARYLPQLGLAVVVPVAVLARIVTEDWVSAAIIVVTLPLIPLFMILIGWATQSRMDRQWQLLSRLSGHFLDVVAGLPTLKVFGRAKAQAESIRTITTQYRRATLRTLRIAFLSSFALELLATLSVALVAVTIGMRLVHGELDLYTGLVVLILAPEAYLPIRQVGAQYHAAAEGLSAAEEIFAVLETEPRAAGTEDVPDSVGLELEGVTVRHESRAEPSLDAVSLTVEPGETIALVGPSGIGKSTLLNVVLGFAVPDEGHVRAGGRDLAELDPERWRNRIAWVPQRPHLFAGTIAENVRLARPDADDEAVVAALREAGAYDFVAELPDGERTLLGEDGAGLSAGQRQRLALARAFLADRPLLLLDEPTASLDGETEAGIVEAVRRLAAGRTVLLVVHRPALLAVADRVVTLEPRDVEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHL0</accession>
    <name>A0A7K2ZHL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001013">
        <property type="protein sequence ID" value="MYW31739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="16526" checksum="23FD4D04FD75EAF1" modified="2021-04-07" version="1">MTVEREEYGSPVGRPRSPRSGNSDWLTGSRITAVQGVFYRPEGRAGEPEAVEFVIDRGESVLLTCTSDWTLCVTPGAWPLLPDWCVPANQWQHAPLTQLPPVPYEGGWTVVGTLERRDGCGEVHEAVIRCREGDFVVAAGDTLAVRFHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI34</accession>
    <name>A0A7K2ZI34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine synthase</fullName>
            <ecNumber evidence="9">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_22655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01001065">
        <property type="protein sequence ID" value="MYW31997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="9"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="176"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="316" mass="33789" checksum="5B731BB5BF08B1A4" modified="2021-04-07" version="1">MRYDSPLAAVGNTPLVRLPRLSPSEDVRIWAKLEDRNPTGSIKDRPALHMVEQAEKDGRLTPGCTILEPTSGNTGISLAMAAKLKGYRIVCVMPENTSQERRDLLAMWGAEIISSPAAGGSNTAVRVAKELAAEHPDWVMLYQYGNPDNAGAHYATTGPEILTDLPSITHFVAGLGTTGTLMGVGRYLRENREGIQIVAAEPRYDDLVYGLRNLDEGFVPELYDASVLTTRFSVGSADAVTRTRELLQQEGIFAGVSTGAALHAAIGVGNKAVKAGEGADIVFVVADGGWKYLSTGVYTAETTEAAIETLQGQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI41</accession>
    <name>A0A7K2ZI41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_22595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001064">
        <property type="protein sequence ID" value="MYW31985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="27390" checksum="C5784C757B9E5409" modified="2021-04-07" version="1">MSTGNGRAAYRPGTEGSRPSKGERTRARILDAAAELFSRSGFNAVSLRDIAAHAGLTHAGLLHHFPGKDRLLLEVLERRDLIDARELFPGLLRPGSPAPEPARRLRLLLELVARNSRTPGLVALYAKVSAEATDPDHPAHAYFARRYRYLRTELTGIVADLQQAAGAGDAADPGVVAGQLLALMDGLQTQWLLEPEAVPMEALVRDFLDRLELLPADGAEATDGAEAGEGVSAETGDGVSAETGDGAETGDGAEAGGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI65</accession>
    <name>A0A7K2ZI65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">secA</name>
        <name evidence="17" type="ORF">GT040_22895</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="WWKE01001071">
        <property type="protein sequence ID" value="MYW32041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="87"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="430"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="849"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW32041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="938" mass="104995" checksum="58D9FCE0C3A412DD" modified="2021-04-07" version="1">MSVFNKLMRAGEGKILRKLHRIADQVSSIEEDFVNLSDAELRALTDEYKERYADGESLDDLLPEAFATVREAAKRVLGQRHYDVQIMGGTALHLGYVAEMKTGEGKTLVGTLPAYLNALSGKGVHLITVNDYLAQRDSEMMGRVHKFLGLTIGCIVSNMTPAQRREQYACDITYGTNNEFGFDYLRDNMAWSQDELVQRGHNFAVVDEVDSILVDEARTPLIISGPADQATKWYGDFAKLVTRLTKGEAGNQLKGIEETGDYEVDEKKRTVAIHEAGVAKVEDWLGIDNLYESVNTPLVGYLNNAIKAKELFKKDKDYVVIDGEVMIVDEHTGRILAGRRYNEGMHQAIEAKEGVDIKDENQTLATITLQNFFRLYDKLSGMTGTAMTEAAEFQQIYKLGVVPIPTNRPMVRADQSDLIYRTEVAKFAAVVDDIAEKHEKGQPILVGTTSVEKSEYLSQQLSKRGVQHEVLNAKQHDREATIVAQAGRKGAVTVATNMAGRGTDIKLGGNPDDLAEAELRQRGLDPVENVEEWAAALPAALESAELAVKAEFEEVKELGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDDLMRLFKAQMVERVMSMANVPDDVPIENKMVTRAIASAQSQVEQQNFETRKNVLKYDEVLNRQREVIYGERRRVLEGEDLQDQIRHFMDDTIDDYIAQETAEGFAEEWDLDRLWGAFKQLYPVKVTVDELEEAAGDLAGVTAEFIAESVKNDIHEQYEEREKTLGSDIMRELERRVVLSVLDRKWREHLYEMDYLQEGIGLRAMAQKDPLVEYQREGFDMFNAMMEGIKEESVGYLFNLEVQVEQQVEEVPVQDAAERTSLSKEGAPAARPEIRAKGLEAPQRPDRLHFSAPTVDGEGGVVEGDFATDGAQSGSSDGLTRAERRKAQKSGGGGGRRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIB7</accession>
    <name>A0A7K2ZIB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001088">
        <property type="protein sequence ID" value="MYW32102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="10810" checksum="72FA0FFEADDA4165" modified="2021-04-07" version="1" fragment="single">MDLTPDPLLVELRAALRTSLAAVPVRSEVHGAPVADGHRGPARAVLDQLGVADFERPASGGGLGLGLTAGVLVSEELGHASCGNAYRADAMAADVGHPPRAALAGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZID2</accession>
    <name>A0A7K2ZID2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001085">
        <property type="protein sequence ID" value="MYW32094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="27125" checksum="B55B4F61FCFB8D29" modified="2021-04-07" version="1" fragment="single">MTSLRTLGSSDLQVFPLSLGGNVFGWTADEDRSFAVLDAYAAAGGNFVDTADAYSAWVEGNQGGESETVIGKWLASRANRSDIVVATKVGAHPDYKGLSAATIKGAAEQSLRRLGTDHIDLYYTHFDDETVPVEEIITALDGLVKDGKVRHIAASNISPERLQESLDFSEREGLARYVALQPHYNLVSRATYEGPLQETAARAGLAAVPYYALASGFLTGKYRPGTSVESARSAKAGEHLESERGRKVLAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIJ3</accession>
    <name>A0A7K2ZIJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="19281" checksum="A0EE0ACDBE6E8C07" modified="2021-04-07" version="1">MSDQSGHETGKPFLYVVVCAAGIAGDVGRLISAAQEAGWEVGVVATPQGLGFIDAPSIEAQTGYPIRSAWRSPADPRPLPPPDAIAVVPATFNTINKWAAGISDTLALGILCESYGLGVPTAVLPYVNAAQAAHPAYAESLRSLRGMGVLIGSYEPHRPKAGGGADRFHWEEALELLAPRLSAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIL3</accession>
    <name>A0A7K2ZIL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="22156" checksum="3B39F37CDA731408" modified="2021-04-07" version="1">MPTTVFDQFTRRTADVTAQLTTLGIPLTAPTPPPADPDPADPWASSYTVPVDRSTLAWCTAVTMLADHHDTGIDRQVLAADALLRELGVRGLAQLHSDLHAGAPVDYRFTRCPYCSAIGEDPTQPDCSEVGCASWLEFAGHDHVCPVCHGEDYQPQWFAEEQMTELEELLTDAIEEREERTSLRYRIRARLYRRTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIX6</accession>
    <name>A0A7K2ZIX6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ORF">GT040_23845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001113">
        <property type="protein sequence ID" value="MYW32219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="243"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="272"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="351"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="52475" checksum="37B2D5FA75129A44" modified="2021-04-07" version="1">MTTVTNRQDFKVADLSLAAFGRKEITLAEHEMPGLMSIRKEFAATQPLAGARITGSLHMTVQTAVLIETLVALGADVRWASCNIFSTQDHAAAAIAVGPNGTPEAPAGVPVFAWKGETLEEYWWCTEQALTWPNTPTGGPNMILDDGGDATLLVHKGVEFEKAGAAPDPSTADSEEYAHILTLLNRTLGEAPQKWTQLASEIRGVTEETTTGVHRLYEMHRDGTLLFPAINVNDAVTKSKFDNKYGCRHSLIDGINRATDVLIGGKTAVVLGYGDVGKGCAESLRGQGARVIVTEIDPICALQAAMDGYQVATLDDVVEQADIFITTTGNKDIIMASDMAKMKHQAIVGNIGHFDNEIDMAGLAAVEGIVKDEVKPQVHTWKFPDGKVLIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELFTKPAEYPTDVYVLPKHLDEKVARLHLDALGVKLTTLRPEQAAYIGVEVDGPYKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ17</accession>
    <name>A0A7K2ZJ17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-deoxy-D-xylulose-5-phosphate reductoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001149">
        <property type="protein sequence ID" value="MYW32332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="8622" checksum="7AEFFDEE17A0EA6B" modified="2021-04-07" version="1" fragment="single">MGGMSDSPAPLADPHLLFDTADGRRDLVILGSTGSIGTQAIDLVLRNPDRFRVTALSAAGGRTALLAEQAHRLRVSTVAVADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ51</accession>
    <name>A0A7K2ZJ51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001153">
        <property type="protein sequence ID" value="MYW32365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="34397" checksum="85519ED13292933C" modified="2021-04-07" version="1">MSSWRSWHRPLVVLSAVMALWALVSAVGLAVDDRVLVGAPIWAKPFKFFVSFAAYGLTLAWMLAQTTWGRRTGWWAGNVVVVTSLVEMVIITGQVIRGKRSHFNAETPFDTSLYTVMGLTVVVLWAAALVIAVLLLRTRLADRATAWAIRGGVLIALAGAAVGFLMARPSAEQRAAGDLDTADVIGAHSVGVPDGGPSMPLTGWSTTGGDLRIPHFVGMHALQLIPLFLIALVLLAPRIARLRDAELRLRLVRVVTAGYAGLVALTTWQALRGQPLVHPDAPTLMAAGALLATVAAGVWAALRTTPAPDPAPAEPASDSKEFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJU5</accession>
    <name>A0A7K2ZJU5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6 7" type="primary">rplM</name>
        <name evidence="7" type="ORF">GT040_25910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001204">
        <property type="protein sequence ID" value="MYW32614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510581.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001204.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="16421" checksum="D0193BA1068802C5" modified="2021-04-07" version="1">MRTYSPKPGDVTRQWHIIDAQDIVLGRLATTAANLLRGKHKAIYAPHMDMGDFVIIINADKVHLSGNKKTQKMAYRHSGFPGGLRSVRYDELLAKNPEKAVEKAIRGMIPKNTLGRQMISKLKVYAGDQHPHAAQQPVPFEITQVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJX2</accession>
    <name>A0A7K2ZJX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator AfsQ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">afsQ1</name>
        <name evidence="5" type="ORF">GT040_26105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001213">
        <property type="protein sequence ID" value="MYW32652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018490978.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001213.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="228" mass="25400" checksum="687BDFF6A268D906" modified="2021-04-07" version="1">MTLVPFLLLIEDDDAIRTALELSLSRQGHRVATAATGEDGLELLREQRPDLVVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARSDDIDVVVGLESGADDYVVKPVQGRVLDARIRAVLRRGERESTDSATFGNVVIDRSAMTVTKGGEDLQLTPTELRLLLELSRRPGQALSRQQLLRLVWEHDYLGDSRLVDACVQRLRAKVEDVPSSPTLIRTVRGVGYRLDSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK53</accession>
    <name>A0A7K2ZK53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_26495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001247">
        <property type="protein sequence ID" value="MYW32723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="355" mass="37993" checksum="1F91F5BE07EEC72B" modified="2021-04-07" version="1">MQPGKGLLMIQFDTVHKRFPNGTTAVHDLTLEMPEGGVTVLVGSSGCGKTTTLRMINRMVDPTSGTIRVGGKDVLEQDAAELRRSIGYVIQQSGLFPHRTVVDNIATVPLLLGWGRRKARARAAELLETVGLSADTGKRYPHQLSGGQQQRVGVARALAADPPVLLMDEPFGAVDPVVRTQLQDELLRLQRELNKTIVFVTHDIDEAVRLGDRIAVFRTGGHLVQSAAPAELLARPADAFVADFLGAERGLKLLSLTTLAGVAQGPAPKGARWQLTLDPARKPLVWRDGESDAEIPVRPLRDTDSLLSALNESIAAPSGLVARVDADGVLTGVTSREDIHDRAGHVHSEASTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL07</accession>
    <name>A0A7K2ZL07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001305">
        <property type="protein sequence ID" value="MYW33023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="18282" checksum="5D1F294AC1610ED5" modified="2021-04-07" version="1">GQAAGQGQAPGLGQGPGQAQGGQPGNAPGVMPTAPTGTGTGTGFGEGMRGGGGGGGLGGLLNGTSVSTEAKALLEKDADAYTWTAAAVGAQNAAGYQLATGDPVMAVGGFNGSDPSPTLARFKKYVAEGKIHYFVSGGTGGGGMGGGGMEGGAVMGGGGNGTSSQISSWVTENFTEVTVGSATFYDLTQPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL38</accession>
    <name>A0A7K2ZL38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001311">
        <property type="protein sequence ID" value="MYW33065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="173" mass="19360" checksum="31647BBA73A7AEB5" modified="2021-04-07" version="1">MNTRYQIAMLMVAKGGGVRDITVGDCLELRETEARVHVHAGSGRSLFYNWLRQLGNFPTEAPTTLRDVSRHSGRVSAAELVDRHQLRCRPVRDLIVDDLTERQPSLDHNSLEDLSRTLARHFWADLERHHPGIGSLRLASTGRNDAAPGPRSADCPTAPQPRPRVLERTASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL47</accession>
    <name>A0A7K2ZL47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="374" mass="39385" checksum="77C45B8CD0A8830B" modified="2021-04-07" version="1">MVQLRRAQWIPVGVIVLAVVIDLATPTDVTSAPLLMAAPVASAPLLPLPGIIAIGALSMAVHSVLAWVDGTFGWKQGVSNQLTLLAVTVLAVLINRTLEGQSARTRRARQVAAVAQAAVLPLPPSRLGDLRIAARYIPAEDEAMIGGDLYVVQETPHGVRVMVGDVRGKGLGAVRAVCADLGAFRFAADQAEDLPGLVTALEGALLREGGRRGGQEEDEGFTTALIAEFTAGLDAVRIVNRGHPPPVLLDAEGTATVLEPSQEAPPLGMAALGIYVFPVDTFPFPPGSTLLCYTDGVTEARDEAGAFYDAAVRLPRLLRHRSLVGDPPAPAQILQLLIEDVGRHTGGRVQDDQALLALHRPAPEAAPVLRRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLF9</accession>
    <name>A0A7K2ZLF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1990 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001349">
        <property type="protein sequence ID" value="MYW33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018960">
        <property type="entry name" value="DUF1990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014457">
        <property type="entry name" value="UCP010260"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09348">
        <property type="entry name" value="DUF1990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010260">
        <property type="entry name" value="UCP010260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1990" evidence="1">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18369" checksum="3EE92FC64E0F8D24" modified="2021-04-07" version="1">MSTLTYPEVGATRLGPLPKGYNHLHHSTRVGRGADDFAVAGAAVTEWRMHRASGVRVDASARRAEPGGTVTMSLGAGPLRLSVPCEVIWTAYGEEGRTGFGYGTLAGHPENGEECFVVDLADDGTVWFTVMAFSRPATWYARLAGPLVPPVQLWYARRLGRTLRRLVAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLT9</accession>
    <name>A0A7K2ZLT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_29685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001372">
        <property type="protein sequence ID" value="MYW33323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="419" mass="42584" checksum="325F5FFD08682EC5" modified="2021-04-07" version="1">DAVIVTAIPWVGENGEAETGDGEVLAAALHGAAAGSPAKPVAVVHVEIGGLAEALAAASSTAAPRTRPTTLAAQPSGPPAAPTPPTPTEPATVEAAGAVEAAGTGEAAGAVEAAGTGEAEGTEPPARPGRIPAYPAAERAVRAMAEAVKYAQWRRQAATPGKVPEFLDETTDEPGAAALIDTLLGATPDPRGRTLAHDEARELLGRYGIPVRPTLPAPDPGAAVAAAARLGYPVALKTTAPHLRHRADLGGVRLDLADEDALRRAYGEFTELLGKPAELLPVVQSMAPRGVDTVVRASIDAAAGAVLSFGLAGAPSELLGDTGHRLVPVTDRDAAELIRSIKAAPVLFGWRGSAPVDTPALEELLLRLSRLVDDHPEVVSVALEPVVVAPQGLTVLGASVRLAPPPPRGDLGPRRLPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM40</accession>
    <name>A0A7K2ZM40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001389">
        <property type="protein sequence ID" value="MYW33402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="269" mass="28956" checksum="391E6F75BDD308E6" modified="2021-04-07" version="1">MPKETAVYTHGHHESVLRSHRWRTAANSAGYLLGELRPGMAVLDVGCGPGTITADVAALVAPGRVTAVDTGPGILEQAAAVADERGLDNVEFAVADVHALDFPDDSFDVVHAHQVLQHVGDPVQALREMRRVCRPGGVVAARDSDYAAMAWYPETPGLAEWQEVYRRVARANGGEPDAGRMLVSWARQAGFTDITPTAAAWCFATPETRAWWSGLWADRTTASVYAELAVQGGHASTDQLTSIAATWRGWGEEADGWFMVPHGEVLCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZML0</accession>
    <name>A0A7K2ZML0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="10849" checksum="AF88315FEB5F47F4" modified="2021-04-07" version="1">MSEPYDFDFELYIALREGLGRRSERSHGAVAFGQLAKVIYQQLGREDALRFFRCAIAETQEPGEHCRHLLLSDRLSRALWTEFGDDEDERVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZML6</accession>
    <name>A0A7K2ZML6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001413">
        <property type="protein sequence ID" value="MYW33519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="6507" checksum="F77FA5CA318962DB" modified="2021-04-07" version="1">VGASGAGVRAVGTAIGRNPLLVVRPCHRVIGGDGALRGYAGGLERKQLLLGLEGAACVERLAKAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPA6</accession>
    <name>A0A7K2ZPA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001561">
        <property type="protein sequence ID" value="MYW34204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="24207" checksum="C6E3C2290AF039F5" modified="2021-04-07" version="1" fragment="single">MLIGEVARRSGVSARMLRHYESLGLVRPSGRTGSGYREYSEEDIRRIFHIESLRALGLSLREVQRALDDADFTPAALVDDLIRRTRERIAAETELLTRLRRIHAADPAGWEDVLQVVTLLQALGSKSADARQRAALASASSASPGSSASSGDEVPVPVEALVEAALGESDPNVAGALRWALARSGDGAPALLAEGIGSPVAAVRERAVRSLAVLPGGEAAGHLREALAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPE2</accession>
    <name>A0A7K2ZPE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1343 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001549">
        <property type="protein sequence ID" value="MYW34148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029464515" evidence="1">
        <location>
            <begin position="29"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="256" mass="26518" checksum="A8679C2BCA4BF096" modified="2021-04-07" version="1">MSLSRRGVLAAGGAVGALAATAAGTAGAAAAARGPGRGRVRTGFDRLAADGYRLLRGQKVGVVTNPTGITADVTHIVDVMHPDDRVNLTAVFGPEHGFRGTAQAGGSEGRYDDPATGLPVYDTYLKSGQPLADVFTASGVDTVLFDIQDAGARFYTYIWTLYDCMEAAALAGKRLVVLDRPNPVTGHGVGLEIEEDPQLAPTAMGKLDACVPVTVEPGVHLPGRGGVRIDDTLVVRPEADGGPELLTMTTKELLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPN8</accession>
    <name>A0A7K2ZPN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001590">
        <property type="protein sequence ID" value="MYW34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="353" mass="37542" checksum="B8A888902D35DCFA" modified="2021-04-07" version="1">MTDLSVPTVDAPGSPATARLLAEAAGRIDAPDVVLAMSRGGVRTVHTGGSGEPGPVARERLHYELGSASKPFAGLLLARLVAQGRVRYEDRAADLLAPGLPVHPAVRRITLRHLLTHTSGLPGLPADFYPQAVPRWSSDPYGNYPADRVVRAFLRARPRHRPGTRWHYSNFAVSVLGHTLAAATGTPWEVLLHQQVLAPLGLEATLLRPGPDSTDATGHRRDGTPLPALDTGGFTAAGALRSTPLDLLTFLEAHAGGAPDSPTDPTLAAALTEVTRPVLRRGWRHAHTHTLTWFQHPTPYGPVLFHAGATLGQQAFLGFRPGAGPAVVATATRRVHRADTFVATVYGLLTETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPP9</accession>
    <name>A0A7K2ZPP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_34860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001592">
        <property type="protein sequence ID" value="MYW34320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="10">
        <location>
            <begin position="111"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="17725" checksum="706C7471CFDE9ECF" modified="2021-04-07" version="1" fragment="single">MSKLRVAVLGANGRIGSEAVRAVEAADDLELVAALGRGDKLEALAEAGAQVAVELTTPASVMGNLDFCVRHGIHAVVGTTGWTDERLAQLTAWLENSPETGVLIAPNFSIGAVLTMKFAEQAARYFESVEVVELHHPNKVDAPSGTATRTAQLIAAARAKAGSAPQPDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPR5</accession>
    <name>A0A7K2ZPR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001593">
        <property type="protein sequence ID" value="MYW34325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="350" mass="39798" checksum="8C9149F730D7F87C" modified="2021-04-07" version="1">DSSATDHTLHFANWPLYIDTDDDNESKRPTLDAFSKRTGISVTYTEEINDNDEFFGKISPALMNHQQTGRDLIVISDWMAARFVRLGWVQEMNRAKQPNVAKYLDPQLRSPAFDEGRLHSVPWQSGITGIAYNRKRLGREIRSTGDLWADDLRGRVTLLSGLDESFALLMQGNGVDITRWTPDDFHEICEQTERRVRSKHIRRFTGNDYIKDLATGDVLACQAYSGDVIQLQADNPDIEFVVPEEGAELWAESLMIPNLARHKRNAERLIDHYYDPEIAAELATWVNYVCPVPAARDILASSKDEETAALAEDPLIFPDDTMRLRLAIARDITSEERTDFAKKWNSIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPT9</accession>
    <name>A0A7K2ZPT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001601">
        <property type="protein sequence ID" value="MYW34360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="149"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="381" mass="40478" checksum="60594F1934CE8CC2" modified="2021-04-07" version="1">MSPLRSNSPLRTAVVGAGGIARTSHLPALRTLAAEGRAEVVAVVDVVEAAARALADEESVPYASADLGSMLADVRPDLVVLCTPPAVHREQTVAALEAGAWVWCEKPPCPSLADYDAVLAAEKGGGHDPYASIVFQHRFGSGARHIGALLADGAFGRPLVAHCQTTWYRDRAYYAVPWRGRWATEGGGPAMGHGIHQTDLLLDLMGPWTEVHGMAARLVHDVETEDVSTAQVRFASGAVATLVNSVLSPDEVSRVRIDCELATIELTHLYGYRDADWRITPAPGVAAETSAAWLDFGEEVPSSHLAQLRVLVDDIAQGRRHATSGEGGRRTLEFITALYRSAFTGTTVRPGDIGPGDPYYTALHGGAPGWAPAGAQEEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPU1</accession>
    <name>A0A7K2ZPU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 6 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mdh</name>
        <name evidence="13" type="ORF">GT040_35045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 6 9"/>
    <dbReference type="EMBL" id="WWKE01001600">
        <property type="protein sequence ID" value="MYW34355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="12">
        <location>
            <begin position="157"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW34355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="34617" checksum="86D376E500ADA36B" modified="2021-04-07" version="1">MTRTPVNVTVTGAAGQIGYALLFRIASGHLLGPDVPVNLRLLEIPQGLKAAEGTAMELDDCAFPLLRGIEITDDPNVGFAGANVALLVGARPRTKGMERGDLLAANGGIFKPQGKAINDHAADDIKVLVVGNPANTNALIAQAAAPDVPAERFTAMTRLDHNRAISQLAAKTGAAVSDIKKLTIWGNHSATQYPDVFHAEIAGKNAAEVVNDEVWLADTFIPTVAKRGAAIIEARGASSAASAANAAIDHVHTWVNGTADGDWTSMGIPSDGSYDVPEGIISSFPVTTKDGKYEIVQGLDINEFSRKRIDASVQELTEERDAVRELGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPW3</accession>
    <name>A0A7K2ZPW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_35145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001605">
        <property type="protein sequence ID" value="MYW34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="538"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="573"/>
            <end position="580"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="841" mass="88066" checksum="C50636C3658CE901" modified="2021-04-07" version="1">PAVQREDRMLRPGGVPIDTSYFTAGGSGKRPAVLIGHGFGGSKNDVRAQAEKLAADGYAVLTWSARGFGKSGGAISLNDPDGEVKDVSGLIDWLAKRPEVQLDAEGDPRVGLTGASYGGAVSLLAAGHDQRVDAIAPVITYWNLADALFPDGVFKKLWAGIFITTGGGCEKFEKRLCEMYERVAVSGKPDAAATKLLSERSPSAVADRIKVPSLLLQGQSDSLFPLGHADAMQKAISANGAPVSVDWISGGHDGGDNETSRVEGRVGAWFDRYLKEETGTGTGPAFRVTRTGGIDSTDGAALKRGASSDTYPGLRSGGREIPLGEGTKTFRNPAGSAPPAISAVPGVGGGLSQLSSLGVGLSLDFPGQFGRFESAPLATSVHVTGTPTARVTVKATEGRDAVLFGKVYDVSPDGRQQVLPSQLVAPYRITPDQQGKPIELALPAVDREFDAGHRMRLVFSATDLGYASPAEPATYNVTLDGPLTVPTAPAVATAAAALPWWTWGLPAAALVIAAALLLTARRRTATPAPDPALTDVPLQITGLSKKYAKSVDRYAVRELSFRVEKGQVLGLLGPNGAGKTTTLRMLMGLITPDEGEIRVFGQAIRPGAPVLSRVGAFVEGAGFLPHLSGRANLDLYWQATGRPAEDAYIDEALEIAGLGDALARAVRTYSQGMRQRLAIAQAMLGMPDLLILDEPTNGLDPPQIREMRDVMIRYAAGGRTVIVSSHLLSEVEQSCTHLVVMDRGRLVQAGPVAEITGSGDMILVTTAEEVSEPLAEKVASLPGIGSAVRTDDGRGLLVRLDGATTSRLVADLVRLDVPVTGVGPHRRLEDAFLTLISGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQS0</accession>
    <name>A0A7K2ZQS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001648">
        <property type="protein sequence ID" value="MYW34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14415" checksum="C0948413AE824946" modified="2021-04-07" version="1">MKSVVVFRIDRRSGVATYLQIVRQVEQALRMGALEEGDRLPTAAQVAATTKVNPNTTLKAYRELERAGLAEVRQGAGTFITRSLAQPRSGPDSPLRASLAAWMDQARADGLTGQDVTALFHSAFETAYPGEAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQV7</accession>
    <name>A0A7K2ZQV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">23S rRNA (Guanosine(2251)-2'-O)-methyltransferase RlmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlmB</name>
        <name evidence="3" type="ORF">GT040_37015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073877001.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001681.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="33678" checksum="1F0E1D7ADEEF8E29" modified="2021-04-07" version="1">MAGNSQRRNRRTSNKKGMQVGSGGQRRRGLEGKGPTPPASARKGHKKNRIAGAQAKQAAARRPAPRRGGVKGTSEMVVGRNPVYEALRDGVPATTLYVQQYIDNDERVRDALKLAGERGNINLMEAPRPELDRMTNGLNHQGLVLQVPPYEYAHPEDLTAAAYDNNEDPLIVALDGVTDPRNLGAIVRSVSAFGGHGVVVPERRAAGMTAGAWKSSAGTAARTPVSRVTNLTRALEGYQKAGLTVVGLAADGEHTVEDLEQLAGPVVIVIGSEGKGLGRLVGETCDYRVRISMPGGAESLNAGVAAGIVLYEVARRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQY1</accession>
    <name>A0A7K2ZQY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NtaA/DmoA family FMN-dependent monooxygenase</fullName>
            <ecNumber evidence="4">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_37245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001687">
        <property type="protein sequence ID" value="MYW34776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="446" mass="49371" checksum="2204DA7A4203874D" modified="2021-04-07" version="1">MSRRIHLALHPYGVGGPGQHGLWKDPRVAKDASIDINYYIQQAQAAEHALFDALFIVDSQFINSTYPAHYLNRLEPLTLLSAVATHTRHIGLVATASSTYNSPFNLARRFASLDLISGGRAGWNVVTSFDTGTSKNFGLDEHLDYATRYGRALEFVQVARGLWDSYEDDAFPADVERSLFLDPERLHALDHVGEHFKVAGPLNVSRSPQGQPVIFQAGVSAEGRDLAARVAEGIYAPGGTLEQAQEYYADIKQRTAAHGRDPDHIKVFIHGGPIVASTDEEARRREREIFEEDNDFERNLALLGRSFGAYDFSVHDLDAPFPDVAHLAEKGGRTGAARIIERAREEKLTLRQVAQEANAFRQSPFVGAPDTVADTIEKWYDAGTLDGINLAFRNNDDLNLFVDGVVPLLQKRGLFRTAYEADTLRGNLGLPIPANRHTRERELAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR44</accession>
    <name>A0A7K2ZR44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001696">
        <property type="protein sequence ID" value="MYW34825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029889128" evidence="2">
        <location>
            <begin position="25"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="249" mass="26273" checksum="007B0A52067BE7CA" modified="2021-04-07" version="1">MRPVRVPVVASAVAALTLLSGCGAAGGLESAGEAPSAVEPARLWPDLPPASAAPYDYGEGETARIPGITVPGGDVHRLDPVAVAQAGLKARTNRDSGLDELPDATVRQIRACRTAPDDCPVLAPYYFDLTGDGRDELVLGVRMPKRQLAVRAYRADQGDGGGLTRIMSTSDAVISVELAGRDLILRAPSAISGYEYRTAWSWDDRQQAMLATRDEILRAPERREGTGRDRTPSPSAPTPESSGSAADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR77</accession>
    <name>A0A7K2ZR77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ORF">GT040_37110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001683">
        <property type="protein sequence ID" value="MYW34749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003964410.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001683.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZR77"/>
    <dbReference type="GeneID" id="6215611"/>
    <dbReference type="GeneID" id="66956293"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="54" mass="6547" checksum="EE4EA15223957E3F" modified="2021-04-07" version="1">MARNEVRPVIKLRSTAGTGYTYVTRKNRRNDPDRMVLRKYDPVARRHVDFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR89</accession>
    <name>A0A7K2ZR89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001722">
        <property type="protein sequence ID" value="MYW34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="385" mass="40421" checksum="04C3AE727B605353" modified="2021-04-07" version="1">MSPSASSPRGAGAPRFAVVGNPENRRVAFFREAVRAAGLEPGRVVSWLQVLRGEAEFEPGETVRIDSPGEDAELERLLRGVDNPTRVEGSARWYAGFLSAVGEVTRAASAAGAEVLTSPGDIAALFDKRLCHALLEGAEVPVPASPTSGPRAAEVRGWSDVRALLREHRMPRAFVKLAHGSSASGVLAVETAGPGRVRASTSVERDAQGRLFNSLRVRRYTTEAEVGALVDALAPDGLHIERWLPKASQRGRAADLRIVVVGGRATHAVVRTSLSPMTNLHLGGARGDLDEVRAAVSAVGGCWREALAICERAAACFPGTLCVGVDLLPSAGWRRFAVGEVNAFGDLLPGLTGLPGSGAEGLDTYAAQVAAVLDRTRNDHALTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR97</accession>
    <name>A0A7K2ZR97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001704">
        <property type="protein sequence ID" value="MYW34866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="29"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="188" mass="20264" checksum="D59CAA9287C5389E" modified="2021-04-07" version="1">AAVLYARPARPVPISYVDLAHQDGARLAAEHLLARDCRRIATISGPLDVPAGQARLAGFRDTMARHGHPYTPIVEGQFTQESGEAAMERLLAEHPDLDGVFAANDLMAMGACHVLREHGRRVPEDVAVVGFDDSSAALACRPPLTTVRQPVEEMAAEMTRLLLDRMVRPAAPATSVIFEPELVVRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRA4</accession>
    <name>A0A7K2ZRA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001708">
        <property type="protein sequence ID" value="MYW34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="32"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="25574" checksum="036791BB757BE016" modified="2021-04-07" version="1">MAPGPAGRTPVFERRPTGGAAGSAAEKAAAEKVVALTFDADMTADQGARAKAGERFDNPELIALLRRLKVPSTVFMTGRWAEEYPAQAKGIGTDDLFEVANHSYSHYAFTADCYGLPVVAKDAMTRDVERAFSAFRQAGVRNVVPYFRFPGGCYDDAALRALGPANVTAVQWDVVSGDAFATDAGAVAEQVLDGVRPGSLVVMHCTRSAAPVTAEAISRIVPELRKRGYRFVKVSGLMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRR8</accession>
    <name>A0A7K2ZRR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001755">
        <property type="protein sequence ID" value="MYW35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="11211" checksum="94B3B766745953B9" modified="2021-04-07" version="1" fragment="single">MTDTLSPPEPTAPAASPPRTGHPARGAFRAELRRGIAPWVAPAMALTIVVPMISKAAQWQGSWGETQGLLHSLTTLIGGPLAAAAGCWQGGREHRRRTAGLSLSVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRX0</accession>
    <name>A0A7K2ZRX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4157 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001776">
        <property type="protein sequence ID" value="MYW35124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="2">
        <location>
            <begin position="105"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="460" mass="48455" checksum="0A8FF26F2B27F684" modified="2021-04-07" version="1">MHGRAHHPDHDEASPTRPPAGRSVRVPALADQEFRPDAPLPPATADFLQRSIGNAALARMVEDQRHVHDPSRSQHPDTAGATEFEVNTPVQRSSVHDVLRSPGRPLSEPVRTEMELRLGEGFESVRIHDGASAARSASEIGARAYTSGDHVVLGHGGTDKHTLAHELTHVIQQRQGPVAGTDTGSGLRVSAPWDHFERAAEANATAALARPLPAPAADRDRLSPGPGPVPLGGANTTGHSFPSPVQRAPSTGSTATGTGTAASVASQAALTNLPADELEGECGYFERRRRLSVNPPQQGLIIQEINRVFAVEQWDGSAWTALPAANIDAYVTAKRSNVFASVGRYWELWIVDAQGNVSDGGEDTFSLASIIPGKKRKDTTRGTYTITGDAQFYPTTVAPSALGFTQGGAGPAGGLFSTLTDPSGAIAASGLTATGQPVRCRVHVAWDSSAPDRYSTVTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS27</accession>
    <name>A0A7K2ZS27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ORF">GT040_39230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001781">
        <property type="protein sequence ID" value="MYW35153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="7"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW35153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="460" mass="52556" checksum="C60C52123A307A58" modified="2021-04-07" version="1">MAADKIDTIVSLSKRRGFVYPSSEIYGGQRAAWDYGPLGVEMKENLKRQWWRYMVTSREDVVGLDSSVILAPDVWVASGHVATFSDPLTECTSCHKRYRADHLEEAYEEKHGKPPVNGLADLNCPNCGNKGTFTEPKEFSGLLSTHLGPTQDSGSVAYLRPETAQGIFTNFGQVQQTSRKKPPFGIAQVGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEEWQQYWMDQRWNWYTDLGMREENMRWFEHPKEKLSHYSKRTADIEYRFRFGGSEWGELEGVANRTDYDLKAHSKASGTDLQYYDQEAGERWTPYVIEPAAGVGRAMLAFLLDAYIEDEAPNAKGVMEKRTVMRLDPRLAPVKVAVLPLSRNPQLSPKAKGLATDLRKNWNIEFDDAGAIGRRYRRQDEIGTPFCVTVDFDTLDDNAVTVRERDTMKQERVSLDQIQAYLGARLIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS41</accession>
    <name>A0A7K2ZS41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001774">
        <property type="protein sequence ID" value="MYW35108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="426" mass="47105" checksum="576C5D22CE656031" modified="2021-04-07" version="1">MTVPNQVSDDRAARIDLADPAFWELPRPERLSAFARLRQLEAPVLFTPRPGTARTSGKPFYALVRHADVLTASRTPKVFASAPGVTTPEPAGWAKALFGNSMVNMDGPEHAALRRIISRRFTPRLLAATEENIGRLAGRLVDEMIAERPGDFMPSAASRLPLEVICDLMGVPGEHRPRIAAQIDHASEHVGVERRGRARLRIPGRGLASLAMMQLVMARLARERRRRPQDDLVSALVRADIEGEGLSSRDLGAFFSLLLVAGVETTRNAIAHGLFLLDRHPEQRELLRSDFDRYIGGAVEEIVRHSTPIIQFRRTVVSECELGGRTFLPGEKVALLYASANRDESVFTRPDLFDITRSPNPHLGYGGGGPHHCLGAHLARLEMTALFRELLTRRPVIRRTGDPKLVDSNFDNRVGSLPFTLDSTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSE8</accession>
    <name>A0A7K2ZSE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0301 protein GT040_40110</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001833">
        <property type="protein sequence ID" value="MYW35314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="186" mass="19539" checksum="21EC42ABEB31745B" modified="2021-04-07" version="1">MTEVSSLTGRLLVATPALADPNFDRAVVLLLDHDEEGSLGVVLNRPTPVGVGDILGSWAGLTGEPDVVFQGGPVSLDSALGVAVIPGDEGPLGWRRVHGAIGLVDLETPPELLGPALGSLRIFAGYAGWGPGQLEGELTDGAWYVVESEPGDVSSPRPENLWRAVLRRQRSELAMIATYPDDPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSJ1</accession>
    <name>A0A7K2ZSJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3039 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001833">
        <property type="protein sequence ID" value="MYW35313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_029395429.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001833.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021400">
        <property type="entry name" value="DUF3039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="10593" checksum="5D9A9AE193A8ECB2" modified="2021-04-07" version="1">MSTLEPDRGAGTGTLVEPTPQVSRGDGDHERYAHYVQKDKIMASALEGTPVVALCGKVWVPGRDPKKYPVCPMCKEIYESMGAGGDKDKGKGGKDKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSM6</accession>
    <name>A0A7K2ZSM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_39600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001797">
        <property type="protein sequence ID" value="MYW35219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="201"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="309" mass="32642" checksum="51FFF5FE981D2178" modified="2021-04-07" version="1">MTSLTSSLVRGAVTSPFKHPGRPGATLPTDRLTLPAAPAAPGPLAAYRRICGFPAPESGPLPLPYLHVLAFPLAMRLMTGRDFPLPVVGLVHTWIEIRSHRPVQPGEALEPTVYAAELTPHRRGTEVTMVTEARVGGELVWESRSGYLSRHATKAEAGAKAEAGAKGEEGAKGEEGAKGEEAQAPALPAVAEWRLPGDLGRRYGAVSGDRNPIHLHPLTARLFGFPRAIAHGMWTVARCLAEADEQPGELRSVRVDFRAPVLLPATVVYAADPAGNTFVLRSESSSGSSSGRGTRSGQVHVTGSVTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSN4</accession>
    <name>A0A7K2ZSN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001804">
        <property type="protein sequence ID" value="MYW35229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="379" mass="39663" checksum="52CF57CEDC8CEAF2" modified="2021-04-07" version="1" fragment="single">MTSAPPLSPLTTSEALPLDGHLVHLPPAPPAGLATATEVVRDHLTRLGARFGPGSGPWHPDGSAAPAPDRYATAGPETVIGLSGPHAQATDLTLRGWPTGDPSPFDETTAQAATGLMALHGRANGGPRPLGTDYLSTLTGVVATQALLAAALSGLRGTPVRSARVSVTEAALFSLGPYVAAATAGDEAEEVPSPPYRRAARPPFLSADGIRFEVEALEVQPWRDFWKAVGAPAKDIANSWRAFAARHTRAAAPLITTLAQCAARHRYADLLLIAERTGMSLCALRTLADRRADSDVRYDDDPWELRELPRDEGDGLPAPPYTSSRPHTGFPQLPLGGLRVVESTRGVQGPLATSVLQALGAHVIRIEQPGGDPSRGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSV7</accession>
    <name>A0A7K2ZSV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF485 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001842">
        <property type="protein sequence ID" value="MYW35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="42" mass="4146" checksum="D0896F43157479B6" modified="2021-04-07" version="1" fragment="single">MEKEAGPAAVGVRLDDPWYEASAAGWDEADGVGGEAADGAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z649</accession>
    <name>A0A7K2Z649_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000020">
        <property type="protein sequence ID" value="MYW27825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="35" mass="3609" checksum="9FCCCB462BC7089D" modified="2021-04-07" version="1">PADKCLDATGNSSANGTRAQLWTCTGAANQKWTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6J8</accession>
    <name>A0A7K2Z6J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000061">
        <property type="protein sequence ID" value="MYW27966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00766">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaG_DnaB_bind" evidence="2">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="20685" checksum="5385E984B3DCF528" modified="2021-04-07" version="1">PRGGRGPGGPQDRRGGAPQHSAQAVQAPTAPSGPALNLRSPAHRTERELLKLALQKPALVSPAFDAYGADEFTAPPYAAVRQCIAEAGGAERGLGDNREYLVAVMDAAPNNTVRSLVTELAVEVFMGRTIDETYAGMQLVHVRLRAVDRRINEVQGSLARLGSNVAPDDLAAAQNEVWVLQQYAQSLRAKGADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6N9</accession>
    <name>A0A7K2Z6N9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">whiB</name>
        <name evidence="15" type="ORF">GT040_01605</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000068">
        <property type="protein sequence ID" value="MYW28001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015611216.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000068.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="14">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW28001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="13113" checksum="92E394E3E83D6BAE" modified="2021-04-07" version="1">MQLEAHAPSVPQSDSISPPGSTEDSTLLPLTALTALDDAIENLGVPVPCRSYDPEVFFAESPADVEYAKSLCRTCPLVEACLAGAKERREPWGVWGGELFVQGVVVARKRPRGRPRKNPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6U8</accession>
    <name>A0A7K2Z6U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000084">
        <property type="protein sequence ID" value="MYW28060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073873920.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000084.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="7535" checksum="038D84F7922D76FE" modified="2021-04-07" version="1">MAAHPPVIVYPPSATGGRRVTVHGQIVGLAHGRGEVAALLRAAGFAPGPDQAVELDRPGLIEWRGGDLDTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7H1</accession>
    <name>A0A7K2Z7H1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ilvC</name>
        <name evidence="12" type="ORF">GT040_03070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01000144">
        <property type="protein sequence ID" value="MYW28281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030573364.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000144.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW28281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="333" mass="36379" checksum="F68EBEF0DF4A7759" modified="2021-04-07" version="1">MAELFYDDDADLSIIQGRKVAVLGYGSQGHAHALSLRDSGVDVRVGLHEGSKSKAKAEEQGLRVVTPSEAAAEADVIMILVPDPIQAQVYEESVKDNLKDGDALFFGHGLNIRFGFIKPPANVDVCMVAPKGPGHLVRRQYEEGRGVPCIVAVEQDASGKGLELALSYAKGIGGTRAGVIKTTFTEETETDLFGEQAVLCGGTAALVKAGFETLTEAGYQPEIAYFECLHELKLIVDLMYEGGLEKMRWSISETAEWGDYVTGPRIITDATKAEMKKVLTEIQDGTFANAWMAEYHNGLPKYNEYKKADSDHLLETTGRELRKLMSWVNDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z814</accession>
    <name>A0A7K2Z814_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000174">
        <property type="protein sequence ID" value="MYW28462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="23363" checksum="91E60743C26FC385" modified="2021-04-07" version="1">MLYGNGFIEDHVRHHSRRCTMTVPAPDSAAEWLLGLLFGPPSLVVSTFVLVNALWAWWSLGRSAVVTATTVFNRSQDRPGRKTLKAGATWRIAVAWTIFYAAASFVTQIWAGSQFSPGQGGGLKELLRWSGIFGALTVAGCFYVTPSQGPRHGDQQWAPYLGMVGGYAFGLIWAVIAFTQRGPEPGDWWVCPAMSCVGVLGSALRMRIRARASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z815</accession>
    <name>A0A7K2Z815_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylalanine--tRNA ligase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000174">
        <property type="protein sequence ID" value="MYW28458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="98"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="193" mass="20185" checksum="550998E494662029" modified="2021-04-07" version="1">KGTPATWADAVEAARSIAAEAGVEVTVRADQHAPWHPGRCAALYVTVNGEETLFGHAGELHPRVIKALHLPERTCAAEVELDVLEQAVDGALQAPRISTFPVATQDVALVVAGDVPAADVERALREGAGELLESLRLFDVFTGEQIGGGNKSLAYALRFRAADRTLTVDEASAARDSAVALAAERTGAVLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z875</accession>
    <name>A0A7K2Z875_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartate-alanine antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aspT</name>
        <name evidence="10" type="ORF">GT040_04265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAE transporter (TC 2.A.81) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000195">
        <property type="protein sequence ID" value="MYW28505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022457">
        <property type="entry name" value="Asp_Ala_antiprt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006512">
        <property type="entry name" value="YidE_YbjL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06826">
        <property type="entry name" value="Asp-Al_Ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03802">
        <property type="entry name" value="Asp_Ala_antiprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01625">
        <property type="entry name" value="YidE_YbjL_dupl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="9">
        <location>
            <begin position="205"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="9">
        <location>
            <begin position="287"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="558" mass="58474" checksum="50B3510BB33A89B5" modified="2021-04-07" version="1">MGVLRDHPELALFFCLAAGYLVGKLRVGPITLGGICGTLIVSLLIGTRHVSVDDDVKTVFFALFIFSLGYMAGPQFFANLNRSSLRFFALCLIELVCVLGIAYGLAKAFDLDVGTAAGILAGAATESAVVGTATEAIGKLSDLTSEQITQYQGHVATAYTVCYLFGLITIVLFTSQIMPMLLRINLADASRELWEKMRGGQSGLESDEREALPGMVGRTYLVTLADGRTVGDLESGLGGHITVEGIKRGSKLLTPSPGLELTLSDLVQVVGRRSAIIEAGREIGPETPAIPGLDTPLATSQVAVTEKATAGSTIDRLEKNHPEFREDGVYITDVLRNDQHLPASGETVLQRGDVLTLVGARGGLGKLVAKIGAVVKNDSTDFVYIGFGIVAGSLLGQIVVKLGDVPMSLGTGGGCLISGLIFGWFRSRKQTFGAFPPQAATTLKDMGLAVFIACTGLAAGPQAWPLLKEYGALLPFAGIAMVLVPATISLIVGRKLLKIEKPLLIGAIAGQQCSTPAITSITQVAQSSVPLLGYTITYTLSNFLLPLTGPILVGVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8G0</accession>
    <name>A0A7K2Z8G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000206">
        <property type="protein sequence ID" value="MYW28585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="12975" checksum="5DBF843BC4E50A78" modified="2021-04-07" version="1" fragment="single">MNRRAFSTLGAPGADLDEVVRLARTGRCQGVELRCSVDQLVYPDMPATEAGRLGAALRRAGLAVPVLASYVQVAADDSGVVERLARHIDLAARLGAAQVRVFGGGADRADGRRERAVRHLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8G3</accession>
    <name>A0A7K2Z8G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000223">
        <property type="protein sequence ID" value="MYW28650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="31"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="25071" checksum="79C50A4A68667330" modified="2021-04-07" version="1">MVRRWARGVPRAFGVRVTVRVRPYAHGTGGELVVANHVSWLDIPLVASVLPGRMLAKSEVGRWPLLGRLAGLGSTLFIDRDRLRALPGAVDTVAEALRSGSRVVAFPEGSTWCGRGSGGVFRPAVFQAAIDAEVSVRPVRITYRAPGAVAFVGDDPLAASLWRVVRAAGLTAEVDVLARIPAGDHAGTSVSGEPGRRGLARTARAAVAGTDRTTTAPEAAVAQTAVASDRANRPAASVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8M8</accession>
    <name>A0A7K2Z8M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_05345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000247">
        <property type="protein sequence ID" value="MYW28707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029444118" evidence="8">
        <location>
            <begin position="32"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="31772" checksum="1D84B4C82F538D62" modified="2021-04-07" version="1" fragment="single">MARRPAGVRTLWLLAAVLALAAVMVASIAFGSRDVPWADVQAALGGAQETLGQAAATKRIPRTVLAVVIGAALGLAGGVMQGVTRNPLADPGILGVNMGASLAVVTAVAFFGLSSPTGYIWVAIAGAALSALFVYTVGTLGRGGATPLKLALAGAATSAAFASLVSAVILPRNDIAGSFKLWQIGGVGGASFERIGQVAPFLAVGFAICLLSARALNSLALGDELAAGLGERVAVARAVAALGAVLLCGAATAVAGPIGFVGLVVPHTCRLLVGVDHRWLLPLSALLGAVLLTAADVAGRIVARPAEIDVGIVTALIGAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z966</accession>
    <name>A0A7K2Z966_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000292">
        <property type="protein sequence ID" value="MYW28891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KR" evidence="1">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="233" mass="24238" checksum="A357A927366CC71E" modified="2021-04-07" version="1" fragment="single">LARHLITEHGARRLLLLSRRGPDSPGADTLRQELTGLGAHVDLVAADAADRDALGRALATIPGDHPLTAVVHTAGVIDDATVASLTPEQLDNVLRPKIDGAWNLHELTRDHDLAAFVLYSSIAGTLGTPGQANYAAGNTFLDALAHHRHAHGLPADSLAWGLWDASTGMGATLSGADVARWTRTGVLPLAEEQGLRMFDTALGADAPLTVAAALDPARIAGSGLPPAVWRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z983</accession>
    <name>A0A7K2Z983_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_06315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000295">
        <property type="protein sequence ID" value="MYW28896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029541582" evidence="7">
        <location>
            <begin position="38"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="716"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="293"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="490"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="745"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="844" mass="87214" checksum="0FE7C7F32E211ABD" modified="2021-04-07" version="1">MFRTALRNVLAHKARLLMTVLAVMLGVAFVSGTLVFTDTLGNAFRNQSAKSYDDVAVAVETYAGGRDEKTPGLDEATLEKIRAVDGVASVTGRVNGFAGVADPDGKLIGNGWSNTGANFAPGKDGKDGAYDFTQGSGPVKNGQIALDKDTASKGKYRVGDPVRVATNGPVKEYTLSGVFTTEDGAVNAGGSLVLFDTSTAQKLYLKPGVFQNATVAAAGGASDQKLLDAITPLLPKEATAQTGKALADEQAEQIESGLTSLNTMLLAFAGIALFVGIFLIANTFTMLVAQRTRELALMRAIGATRRQVKRSVLIEAAVVGALASVIGFALGLGLATGLRSAMGLLGGKIPAGPLIVSPTAVLSAFAVGIVITILAAWLPARRAAKIAPVAAMSSVHATASVKSLVVRNSIGGFIALLGAVGIVGGAATGGTNGRYLVAAGAFLALIGIIILIPLLSRPVIALVRPAISKLFGVSGKLASQNAVRNPRRTGATASALAIGLTLVTGISVLGVTLGQAIDKMTTDNIKADYMVSMASGDSLDKSALTALSKADGVSALSPQQASSLRVDGEYHSASGVTPGDVEKVFALDTVSGSLATLKDGQVAVGSKTAKSNGWKTGDTLPVQFDDEKKGEVTIGALYKENEFLSPFVIPKELADRHSASSRPEIREIWIKADGGASQANEQSIVDALGDNPAMSVMDRQDIRDMFGGFINTALNIMYGLLAMALLIAVLGVVNTLAMSVFERQQEIGMLRAIGLDRAKVKRMIRLEAVVISVFGAVIGVGLGVFLGWAIGQTLAADIPGYALVIPWDRLAIFLALAGLVGVLASLWPARSAAKLNMLTAIKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9D4</accession>
    <name>A0A7K2Z9D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000277">
        <property type="protein sequence ID" value="MYW28875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="16929" checksum="F7C9190FB99411AF" modified="2021-04-07" version="1">MGSDEGAGFEPATGDGPPPTEAAEVRAASVRTAFEGLLQIRRLTGDGRTGDPEAAPAPWELHRSVRAVALALESSGATPSAVDASGHRVSAGYRVRTGERAGSVRVDWAGPPGSGAAHHEEEALGECAEVLRQLGWTVLLYRGPRRRRYLEVEPPAGVAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9H6</accession>
    <name>A0A7K2Z9H6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_06865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000307">
        <property type="protein sequence ID" value="MYW29003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030572159.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000307.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="101" mass="10918" checksum="FC3BC47C384E897D" modified="2021-04-07" version="1">MSAEPLSKTETEHRLESLPGWALEGDRITRTYRLPSHFAAAALTVHIAQIQEELNHHSDLTLGYNTVALSVHTHDAGGKVTEKDLELATRVTAAAPGHGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9M8</accession>
    <name>A0A7K2Z9M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000307">
        <property type="protein sequence ID" value="MYW29002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="273" mass="30478" checksum="091D8058D13EC889" modified="2021-04-07" version="1">MTTVFPDTGVGPLLRDWRERRRISQLDLALRADSSARHISFIETGRSRPSEDMVLRLAEQLDIPVRERNALLVMAGYAPRYAQTPLDDPAMVSVRDGLDRLLAGYEPYPALVVDGRYDVVAVNRGIALLMEGVAEELLTPPLNAMRITLHPAGLAPRIRNLAEWRADLLTQMERQIALVRSPELRTLYEEVAGYPVPDRADRDAEGRGTDRARERTPSFALPLVIEHGGQVLSFIASIATFNTPMDVTVAELAIETFLPADRETAAYLRERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA40</accession>
    <name>A0A7K2ZA40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="2">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mca</name>
        <name evidence="3" type="ORF">GT040_07875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000362">
        <property type="protein sequence ID" value="MYW29198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="293" mass="32862" checksum="F07EB17379555CA5" modified="2021-04-07" version="1">MTEQLRLMAVHAHPDDESSKGAATMAKYVSEGVDVLVVTCTGGERGSILNPKLQGDAYIEKNIHEVRKKEMDEAREILGVQQEWLGFVDSGLPEGDPLPPLPEGCFALEDPQVGAGRLVAKIRAFRPQVITTYDENGGYPHPDHIMTHTISMIAFDGAADAGAFPEDEFGPVWTPQKLYYNQGFNRPRTVALHEALLARGLESPYGEWLERWKEFERVERTLTTHVPCDEFFEIRDKALIAHATQIDPEGGWFRVPMEVQREVWPTEEYELAKSLVDTSLPESDLFAGIRDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA57</accession>
    <name>A0A7K2ZA57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000367">
        <property type="protein sequence ID" value="MYW29218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="10574" checksum="C3367BA3AC6CA802" modified="2021-04-07" version="1" fragment="single">MDPTHQGPEEYGRTPGGSDDSDRSAGRRRPSRESNAADFGQPTPQQVRVVQVTVGDLLLTVNPVDGSEVEACPPGYEPDAPVRRTLSERAAHERAGAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA61</accession>
    <name>A0A7K2ZA61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_08000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000367">
        <property type="protein sequence ID" value="MYW29223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="9"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW29223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="249" mass="26728" checksum="86C711CD06718946" modified="2021-04-07" version="1">MLFHDTAIVFGRYARQTLRSRFQVLFGLLMPLLHLFFFGPLLQDLPLGSSAGSWQVLVPGLLLQLSLFGASFAGFAIIIEKSTGVVERMRATPVSRLALLLGRVLRDALLFTFQAVLLVLAALLMGLRAPLAGVLIGFAFTGVLALALASLSYALAMRVSTPQEFGPVINAVTMPAMLLSGLMLPITLGPAWLDVVSHFTPFRYLVDAVRDAYTGSYATAHMLYGVLVAVGFALLAVTVGTRVFRQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAD4</accession>
    <name>A0A7K2ZAD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000398">
        <property type="protein sequence ID" value="MYW29320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="11408" checksum="DBCC67FC2A5D50D9" modified="2021-04-07" version="1" fragment="single">PEGGSYAVPGLYDWLHELPFVAERHSGHSRYHAVVRAPMLRLQRTGSPRRWKAAHDRLAEAFAARRDAAAEGIDPERLWAEQPWRRAALEVLYHRLCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB23</accession>
    <name>A0A7K2ZB23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_09835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000454">
        <property type="protein sequence ID" value="MYW29567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="27810" checksum="8BBDE817E7110587" modified="2021-04-07" version="1">MLVHSRTGKWATWSAFALLFLPLFAVPLLVILAASFSTNWSGALPSGPTATRYAAATSGDSLQALTTSLVTALCASVLALVLGGWAALAASALGRRGKRFLDALFMLPVAVPSVVVGLAVLVAFSRPPVLLNGTRWIVIIAHTVLVTAFAYQSVSAAARRLDPMYEQAAASLGAAPGRVLWRVRLPLLLPSLTAASGLCFALSMGELSATMMLYPPDWTPLPVQIFAATDRGSLFTGAALAVVLMGTTLLVLTAVSRIRTRASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBF7</accession>
    <name>A0A7K2ZBF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_10355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000476">
        <property type="protein sequence ID" value="MYW29669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="108"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="284" mass="31415" checksum="60EEA05728C9A9C3" modified="2021-04-07" version="1">WCQLFSEPGAGSDLAALATRAVRDGDDWVIDGQKVWTSSAHVARWAILIARTDPDLPKHRGISYFICDMADPGVDVRPLRQITGEAEFNEVFLSGVRIPDSHRLGPVGDGWKVAQTTLMNERVSIGGSRIPREGGMIGPVSQTWRNRPDLRTHDTHQRLLTLWVEAEVARLTGERLRQQLVAGQPGPEGSGMKLAFARLNQQISGLEVELLGDEGLLYGDWTMVRPELVDFTGRDAGYRYLRSKGNSIEGGTSEVLLNIVAERVLGLPAEPRNDKDVAWKDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBX1</accession>
    <name>A0A7K2ZBX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_11265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000508">
        <property type="protein sequence ID" value="MYW29844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="31975" checksum="E50DA4A544C5DFA2" modified="2021-04-07" version="1" fragment="single">MPQNTDTSYEPVLSAEVRAALAGGLPVVALESTIIAHGLPRPRNLRVAIELEGIVRSAGAVPATIAVLDGQAHVGLEKDQLERVAGDPAVRKLGHRDLAPALALGASGATTVSATAFLAARAGLRFFATGGLGGVHREWADSQDESADLRLLARTGITVVCAGVKSILDVPATLQRLETLGVGVLGYSTGHFPGFYLSSSGQPVDWTVHSPEEVVEVVRAKEALGGPEAALIVANPVPEQDQLDPALHDRVLAEALDACRERGITGQGVTPFLLEELMRRTEGASLEANLAAVRGNVRLAARIAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC09</accession>
    <name>A0A7K2ZC09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000520">
        <property type="protein sequence ID" value="MYW29879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="17455" checksum="2609E370E31C43F0" modified="2021-04-07" version="1">MATRDTPPPRTGTSEAETLRGFLDYLRTSVAAKVDGASEPEVRTAAVRSGTNLLGLLNHLTYVERAIFLGEHVADWQATFRAAPEDSVAEVVARYRTAVESANTVLDGCTDLAAPVPRPESGARPGKPAPSVRWALAHMIEETGRHAGHADILRELIDGSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCI6</accession>
    <name>A0A7K2ZCI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000580">
        <property type="protein sequence ID" value="MYW30066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6343" checksum="8F369C909CE1E592" modified="2021-04-07" version="1" fragment="single">MSAYGPTGTTPYGPYGPTELLVIAKEPVPGRVKTRLCPPFSPAEAAELAAAALADTLETVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCR4</accession>
    <name>A0A7K2ZCR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000600">
        <property type="protein sequence ID" value="MYW30150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="383" mass="42859" checksum="03ED024C19B69556" modified="2021-04-07" version="1">MAAKKHPARTMAATEHPAVLSTRALNRATLDRQLLLRRSAMSAKDAVAHLVGLQAQNTKPPYFQLHARLAEFDPRELSALMESREVVRIVTLRSTLHTHTADDTLTLRPLVQAARDRELKAFRHGLAGVDLARLAAVSRELVEERPRPVKELRAELSARWPEADPLALTVAARCLLPLVQVTPRGLWERSGQVALTTAEHWLGRSSEPVPAPDATVLRYLNAFGPASVKDMQRWAGLTRLREVFDRLRPRLRTFRDENGTELFDLPDAPRPDPDTPAPPRFLPEFDNVLLGHDDRSRVIAEVNKGRNGVGNQSYGTVLVDGFFEAIWRVERDGDAAILTVQPLRTLRRDERDGITEEAVGMLSVMTDATSYDVRFGTFLDFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD75</accession>
    <name>A0A7K2ZD75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000630">
        <property type="protein sequence ID" value="MYW30269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="15"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="31484" checksum="16854B9E9FAC7728" modified="2021-04-07" version="1" fragment="single">MTRRTGTGAGARTRTVTVVGAGIGGLATAIGLRRAGWSVTVLERRTELERYGAAFGIHPTAQAALDRLGAGAALRDHAVPYRDARIRTPGGRVLARLPLERIEKKAGRPELLISRPYLVDALLAGLDAFGDVPVKLGETVTQVSALAAGSDLVVGADGIRSAVRTSHFGDRSGPREVGTVAWIGIAGFESPVHGETWGSGRFFGLTPVEPGRTNWYATVPEVTTADELRASFAGWHDPIPRILDATDPDTWIRYEMRHLYPALPSFVSAGASAGHVALVGDAAHAMTPNLGQGACTAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD93</accession>
    <name>A0A7K2ZD93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_13640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000651">
        <property type="protein sequence ID" value="MYW30302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="3">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="20342" checksum="EE4D7A43C7AF3C63" modified="2021-04-07" version="1">MGPEGGRRWRCRQEEVGGRVRSQARGGGPGGERFRGTDRGVATVWVAVTTVALCAVFALVLELGQAVTARHRAGGAADLAALAAADRALEGPEAACEAARRVALAQKAVLVRCSVQGEIADVVARSSLGRYAPAVRARAAPPAGPRAVVAGRSSFASATSQRTVSAGPDVRVGRCERDLQASSPAAQAVSPPHSSRTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDH6</accession>
    <name>A0A7K2ZDH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041479">
        <property type="entry name" value="TetR_CgmR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17937">
        <property type="entry name" value="TetR_C_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="19789" checksum="07C3E8C86C2B451E" modified="2021-04-07" version="1">MRTSKRTQILEAATRVVEREGVKSVTFDAVAAEAGLTKGGLLYHFASRDDLVQAIHQHLADAWEAQMVAAAGKSADLATPEERLTAYSRISTRSATRAELLFMLEGSTTPGHAAPWDAVMERWAPSLTTDDVDDRAALDRFIARLAADGLWLYESLNTEPLAPELRRALAERIAGALDPEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE66</accession>
    <name>A0A7K2ZE66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ORF">GT040_15485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="WWKE01000724">
        <property type="protein sequence ID" value="MYW30644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="288"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="460"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW30644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="615" mass="65796" checksum="E829F018657051CE" modified="2021-04-07" version="1">MCGIVGYVGGQSAQDVVVAGLKRLEYRGYDSAGVAVLADGGLAAAKKAGKLVNLEKELGDRPLPAGRTGIGHTRWATHGAPNDVNAHPHLDNAGRVAVVHNGIIENFAALRRELTGRGHALGSETDTEVVAHLLAEAFSAGGDLADAMRQVCRRLEGAFTLVAVHADQPDVVVGARRNSPLVVGVGQDEWFLASDVAAFIAHTRSAIELGQDQVVELSREGVTVTGFDGDLAEVREYHVDWDASAAEKGGYASFMLKEIADQPQAVADTLLGRIDGEGSLSLDEVRIPDAELREVDKVVIVACGTAFHAGMIAKYAIEHWTRLPCETELASEFRYRDPILDQRTLVIAISQSGETMDTLMALRHAREQGAKVLAICNTNGSTIPRESDAVLYTHAGPEVAVASTKAFLTQLVACYLVALYLGQLRGTKWGDEIRTVVRQLSAISGEVERVLETMEPVRALARSLAHHDTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEEGLPVVVIVPSPRGRSVLHDKIVSNIQEIRARGARTIVVAEEGDEAVVPYADHLITVPATPTLLQPLVATVPLQVFACELATARGNEVDQPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE78</accession>
    <name>A0A7K2ZE78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_15595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000729">
        <property type="protein sequence ID" value="MYW30663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="40"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW30663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="30444" checksum="BB89154284DEB057" modified="2021-04-07" version="1">MSTTTTLTPAPAGSAGTNPPKAQAQATGEGRIGLRANLRHIGALARRNLLQIKKDPESMFDVLLMPVIFTLLFVYVFGGSVGGSLGGDRQDYLNYLVPGLMAMMGMNIAMAVGTGVNDDFRKGVMDRFRTMPIARSSVLIAKIVVELGRMMVAIAILLAMGFALGMTLGTSVLGLLEAVALAAVFGAAIMWIFIVLGLSMKTAQAVQGMGMLVLMPLQFGSSIFAPPQTMPGWLQAFTDYNPLSNLADAVRGLMMGGPVAGSVWTTLAWAAGITLVMAPLAVSKFRKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE95</accession>
    <name>A0A7K2ZE95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="250" mass="26271" checksum="CB1DBEC51E516B4B" modified="2021-04-07" version="1">MVLTPLPDSRTEPDGSAVIRVLSYNVRSMHDDTAALARVIRACAPDLVLVQEAPRFFRWRKAAARLAKSSDLVVLSGGATAAGPLLLCSLRAAVESTEDVLLPLTPGLHRRGFATAVVRIGGVRLGVLSCHLSLQREERLAQADLLLERLASMGVQHAVAGGDLNDVPTGKAFQHLAGHLQDCRAVAPWGGELTFTPDDPRKRIDAVFATPGIEVLGCGVPAGLPGVSEEDLRAATDHLPVLAALGVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEH2</accession>
    <name>A0A7K2ZEH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_15960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000749">
        <property type="protein sequence ID" value="MYW30732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="167" mass="17954" checksum="DC708F818F5B93C5" modified="2021-04-07" version="1" fragment="single">SLEALALGDAFGERWFPLFRERQQAANEIRARRTPQEPLWHWTDDTALALALHRSLDERGLVDQDHLALRYALAFDADQARGYGHGMHLLLPQLLVAPADWRTLAPGLFDGGSLGNGAAMRVAPLGARFHEDLDRVAEQAALSAAVTHAHPDGIAGAVAVAVAAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEM2</accession>
    <name>A0A7K2ZEM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000762">
        <property type="protein sequence ID" value="MYW30800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036471">
        <property type="entry name" value="Colicin_D_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="27484" checksum="45B22547CBE28DEE" modified="2021-04-07" version="1">MVGSNEGRAGDATAVLDGRGTFSEQWLSAGGKKIVPVPAGSLTDGSLVRRVIEGCRAAGADVVLVMRPSAGAAAPADSLPPTDPGLVALPPPLLLAAANLEGAVLFPRPGYALVAGTSVFLAGAAAEGVDQGRARFARYVRAAEPEWPGLKATARSFPPGHVAWKHPEDVPVDTATGRQLALMRDVAAGHCTGAEFAVGWLDARRRSQQQGERVRDPLETLLDRVFSLLEDYSIDPQFKEPDDLSDDGLKNAVIRLLHKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF19</accession>
    <name>A0A7K2ZF19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000806">
        <property type="protein sequence ID" value="MYW30957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="187"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="399" mass="41523" checksum="52D3C9685C4F4FF7" modified="2021-04-07" version="1">MTAPGTERAATQDGKVVDERLGALKAAVRDTVTIHAEALLDLSRRIHADPETAFEEHRSAALCAELLAAHGFDVTAPAHGLETAFRATIGSGPVTVAIACEYDALPGLGHACGHNLIAAAGVGAALGLAPYADELGLTVRVIGTPAEERGAGKALLLEAGAFDGVDAAMMVHPCPFELADFRSFALGTLDVTYIGRTAHPSLNPHEGRNAADALTVAQVALGLLRQQLPPQWRVHGITTAAGTSPNVIPDRATATYEIRALAAEDLRELRQRVEDCFRAGALATGCEVALEQPEPDYLDFRGDAELLRLWTANARVLGRAESVERPPFACTDMGNVSHVVPSIHPVLDISGGACGPHEPEFVAAAVSPAAEQALLDGAVGMAWTAADFAAARKAAAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF35</accession>
    <name>A0A7K2ZF35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2637 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000804">
        <property type="protein sequence ID" value="MYW30928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="53462" checksum="23877F3F7202451E" modified="2021-04-07" version="1">MAAIPLTRTHRILIGIVVAGAVIIAAIGFAGSYAAVRELAEAKGFGEFSLVFPIGIDAGICVLLALDLLLTWMRIPFPLLRQTAWLLTAATIAFNGAASWPDPLGTAMHAVIPVLFVVSVEAARHAVGRIADITADKHMEGVRLTRWLLSPVPTFKLWRRMKLWELRSYEQVIKLEQERLIYQARLQARFGRNWRRKAPVESMMPLRLAKYGVPLAETAPAGLAAAGIEPALLPPAPKAELPYEPWREQDLEHGYEQGQGREEQAPQQEQAHPHPQQHPQQQQPTSLQKQGPQQLQAQAQLPEQAAPTHDSPWFAAQKLPEGPHASAYDPLHAEGLEPTPAAVPLGPGRTRPLGNVGTIGAVPHPRREEPQDTPEPVQQAQPAQQAQPVQQAADEEPPAVPAPGPEDAPQLEEWSQEDNDFADRAYEEFSAYTDEVGEFPNVETLDIHLADRRDVHHPRSTALLLDLMPQFKNLYTQRATADQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFQ5</accession>
    <name>A0A7K2ZFQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="26902" checksum="C6B1666861FC551B" modified="2021-04-07" version="1">MSTTRHLVNRRRRLATSPSRPSPSTELPAKPVTDEEADAATEAEREPEAVTESASDPASDFASNSEPEPDAAATSRRRLRPRLPALLCALTVLLGAFAVWAFTSAASLRETPARQNTALTDIARTSEVKGRIGEAVGAVFSYDYASPARSDRAARTHLTGRAVQQHKDMLAEVRAQAPQQKLVLTTTVTASGVEYLDGDRARLLIFADQSNTRTGKDEETTYAAAMFAVDAVRRGDTWRIAAIDTFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG46</accession>
    <name>A0A7K2ZG46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000902">
        <property type="protein sequence ID" value="MYW31341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="262" mass="26905" checksum="4D84696A48841C82" modified="2021-04-07" version="1" fragment="single">LRYEAEARRGVDGTDLVREACMREHIAEALANGRRPAVVVGAFHTPALLPYAEGAATAPAPGAPHAADAPDVPDAGDTPRAAKAPDAPRAAKATDAPNTLAGAPKAPAREPGAGVAAACTVSLIPYTYPLLDSRSGYPAGIRDPEWQHTVLDAAGDPSALHEALVRTAVRVCVALREQGHPYGPADGREVVRVAGDLARLRDLPAPGRGELLEAVQTVLGRGETYGTGRAVAHALERVLVGTRTGRPTPAAPRSGLGPAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG75</accession>
    <name>A0A7K2ZG75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_19195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000901">
        <property type="protein sequence ID" value="MYW31340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="21610" checksum="D2F38F7ACD36B47D" modified="2021-04-07" version="1" fragment="single">VNFITTIICMRAPGMTMFRMPIFTWNVLLTGVLVLLAFPVLAAALFALEADRKFGAHIFDSANGGALLWQHLFWFFGHPEVYIIALPFFGIISEVIPVFSRKPMFGYIGLIAATIAIAGLSVTVWAHHMYVTGGVLLPFFSFMTFLIAVPTGVKFFNWIGTMWKGSLSFETPMLWAVGFLITFTFGGLTGVILASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGH1</accession>
    <name>A0A7K2ZGH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Htaa domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000910">
        <property type="protein sequence ID" value="MYW31389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007331">
        <property type="entry name" value="Htaa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04213">
        <property type="entry name" value="HtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029702507" evidence="2">
        <location>
            <begin position="31"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="HtaA" evidence="3">
        <location>
            <begin position="37"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HtaA" evidence="3">
        <location>
            <begin position="251"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="456" mass="46346" checksum="93F6139EE3292451" modified="2021-04-07" version="1" fragment="single">MLPSRSARALAVALLAVLLGALLPAATAQAASRTVQGGRLDWGIKSSFQSYVTGPIAQGSWSLTGGAATVGGSQFRFHSANGSYDPATGALSSGFSGGVHFTGHKKADGTNELDLVISRPTIRISGGSGTLFADMVSKERGTGKVSNRSQVPLATLGLGGINMKGGSTPIALTNVPTTLTAQGASAFAGYYTAGTPLDPISLSVDTRAPAEQPKPAPSATKDEDAKKPEGEKKKDAEKAKGQEKAGRFEDAAVDWGVRRTFREYVTGSIGQGKWTLADGAQDGGALFRFPQGKGTYDAKKQTLDADFGGSIHFTGAHDLDLKFAGVTVAVTKGEGTLSADVTSAGTTRKDVPLITFAAKDFAPREGLAVLTEVPATLTEDGAKAFGSMYKAGTEMDPVSLAVAVDDKAQLPPLPDLGSEPTAAAEPTAKPSAEPSAAPAAATSDSGPGAGTYAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGI6</accession>
    <name>A0A7K2ZGI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000916">
        <property type="protein sequence ID" value="MYW31428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7187" checksum="3B0AD9940EEF4ABD" modified="2021-04-07" version="1">MDPYDSQTSQSAEPWSAPGGTPIYDRLVAEWRAAGHDHPSAEPRQEPASRRGGGFVPAARTPDDAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGK7</accession>
    <name>A0A7K2ZGK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000930">
        <property type="protein sequence ID" value="MYW31487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="17702" checksum="3F6CB5A514A887B0" modified="2021-04-07" version="1" fragment="single">MRHVIALDVGGTGMKAALVGTDGTLLHEARRATGRKRGADAVVETILAFAADLRAHGEEHFGESAVAAGVAVPGIVDAEKGIAVYATNLGWRDVPLRALLGQRLGGIPVALGHDVRTGGLAEGRIGAGRGADRFLFVPLGTGIAGAIGIAGRIEAGAHGYAGEIGHIVVRPEGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGT8</accession>
    <name>A0A7K2ZGT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YtxH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000944">
        <property type="protein sequence ID" value="MYW31528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030564731.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000944.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11099" checksum="587C68AA4CBC1800" modified="2021-04-07" version="1">MRYRLTFIAGVALGYVLGTRAGRERYEQLKKSARQFTENPAVRNAAESAAHSGRDIAGKAYHSVSDKVGDKVPASVAERVRSLKERSSQNGGAEDDWGTTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH76</accession>
    <name>A0A7K2ZH76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1298 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000999">
        <property type="protein sequence ID" value="MYW31713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045017">
        <property type="term" value="P:glycerolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WS_DGAT_C" evidence="1">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="18483" checksum="1E807F075F839D0B" modified="2021-04-07" version="1">AATDPRALVPVSRRRPGGAVSGNRLSAYLLDLPVGAADPRERLRAVRGGMDRNKAAGPLKGAGAVAVLADQLHPLAHRFGAPLAANAARMLFDLLVTSVPLPRSALSLGGCPLSALYPMAPLARGQSLAVALSTYGGRVHVGLVADGKALPDLDRLAGAVEEEFDEIGALFTAGRVAAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHG0</accession>
    <name>A0A7K2ZHG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001016">
        <property type="protein sequence ID" value="MYW31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026242105.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001016.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="27196" checksum="505D349ED8536C5E" modified="2021-04-07" version="1">MPRMLDVSQDVRAEIGDDEADRLLVGDDTPGSYDCTSCRTPGDSDQERTSTVLFIGDETAVLAFAHATCIPSQVVKVAEDQLQGAVRSITGSEQKNTEGRMPEQAVLGITSGLVLIEDDVRPALVVEPTGPVARPGTDGSGGDEFLQLLLEQGFHPAPDLTALPAPLPGWSVLLAVGQLHAVLQPGSGGGNPVAWWQAHQPLQVTDGWRAAVNKSQTVLVFAAPAGTIGQQPREDLLRDALEKAAVNGVLVAASMPLAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHG2</accession>
    <name>A0A7K2ZHG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_21605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001019">
        <property type="protein sequence ID" value="MYW31803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="256"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="386" mass="43015" checksum="F1119455AD5B4844" modified="2021-04-07" version="1">HVVWLLPDPAAALAHWFGLLKPGGRLVLIEGVWGGVGLSAARVTALLAPHTERVHHEDLAGDPRLWGKEVDDERYALVARAEPPHRHTEVVDVHLILRRGPDVLLARRANTGYADGLLHMPSGHAEDGEDIREAMIREAAEEVGVVLDPDDVRVALVMQHRGPGGGARMGWFFVAEYDAEHPPHNAEPEKCSELDWFPLDALPDDMVAYCRAGLDGYRAGEHFMIHWHEDGDPIAHRPDGPRRAVALPPAAERTGRVHHIELRVPDLAGAERRWGWLLTRLGHLPYQRWAEGRSWRRGESYVVVEQSPDLSADHHDRRRPGLNHMAFHVADRATLDALKAEAPAYGWRLLHPERHPCAGGDGHRAACLEDEAGYEVELVVTSEPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI90</accession>
    <name>A0A7K2ZI90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001073">
        <property type="protein sequence ID" value="MYW32057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="22973" checksum="6C60995AC9EDA430" modified="2021-04-07" version="1">MAAPTGGHPYEGDQRVPGEHGDNRFGYPAASGGQGPGNAYQPYQQPQQQHGAHGAQGSEWPQQQPGSPWPQQHQPQQRYDAPQQQRIQPVQQQRAPEPAAHNPLVRPYAMTGGRTRPRYQLAIEALVSTTADPSRLQGQLPEHQRICRLCIEIKSVAEVSALLSIPLGVARILVADLAEAGLVAIHQPGGDEAAGGQPDVTLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZID6</accession>
    <name>A0A7K2ZID6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001086">
        <property type="protein sequence ID" value="MYW32098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="1">
        <location>
            <begin position="409"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="522" mass="55967" checksum="4B8B5A2A52AC487C" modified="2021-04-07" version="1" fragment="single">FRHDSIPAGIAALRQLGAANNFTVTATEDAAAFTPANLTGYEAVVFLSTTGDVLNAAQQTAFEGYIEAGGGYVGIHAAADTEYDWAWYNGLAGALFKSHPHIQPATVKVEDRAHDATAHLGPTWQRTDEWYDYRTNPRSSAHVLASLDESTYSGGTMGGDHPIAWCKDYRGGRAFYTGGGHTQESFAEPAFRRHLLGGIRWAAEMTEADCRPETGYTTLFGTSGTTGWKQAGPGSFTHTNATLTSQGGLGLYWYQAKEYTSYSLKLDWRQSGDDNSGVFVGFPASDDPWSAVNNGYEIQIDDTDTPDRTTGAVYGFKSADLAARDAALNPPGEWNTYEIRVEGERLQLFLNGRKINDFTNTDPVRSLQQGHIGLQNHGDGDDVSFRNIRIKELGGATGPREGAITGIGGKCVDVANGSSADGTQIQLWTCNQSTAQRWTAGTDDTLRALGKCLDISGAGTADGTKIQLYGCNGTGAQKWVAQPDGTLKNPSSGKCLDASGVSSVDGTKLHLWTCHTGANQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIY4</accession>
    <name>A0A7K2ZIY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_24345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001144">
        <property type="protein sequence ID" value="MYW32313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASH" evidence="4">
        <location>
            <begin position="41"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="4">
        <location>
            <begin position="313"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="590"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="813" mass="86048" checksum="93674B78889E0A23" modified="2021-04-07" version="1">MAQGTVQVTHTGTSRWRRRTGEYASLSAALEAAADGDVLTVAPGTYRENLVLHRAVTLRGPEGSVGSVRIAPVDGVPLTVRASAIVQDLHIEGQDSAAPAVLVEDGTPEFSDLRIVTRSAAGIEVRGAARPTVRRCTVDNPAGVGIAVLDGAGGVFEECEIVAAGQSGVSVRDGGHPRLDRCRIHHSSGAGIGVTGEGSGLEAIGCEVYEVKGSGVQVTARATAHLTDCTVHRTSGDGVTLDTDAVLTLADCDIHDIPENAIDLRSRSVLTLTRSTVRRFGRNGLSVWDPGTRVDANQCEIHDSTGDYPAVWVSDGATVILDACRVHDVPDALFVLDRGSRADVVDSDLSQIRNTAVSVSDGATAQLDDCRIREASTGAWFRDHGSGGTLNNCTIDAAQTGVIVTKGADPVIERCTVTNPAEAGFYVSAEGRGTFDSCRVTGSEGYGFHVMDGCRTTLTRCRTERCARGGYEFPEGFAGPTGDGSGGSGPVVTDCTSDESGLRTAPAPAPAVLTATQSTPGLLNTMPGQRAVEPEPVAPAAEPARDSAAVLGELDALVGLESVKREVRALTDMIEVGRRRAEAGLKAASVRRHLVFTGSPGTGKTTVARLYGEILASLGVLERGHLVEVSRVDLVGEHIGSTAIRTQEAFDRARGGVLFVDEAYALSPEDSGRDFGREAIDTLVKLMEDHRDAVVVIVAGYTHEMERFLTVNPGVASRFSRTITFHDYLPEELLRIVEQQTEEHEYSLAEGTGEALLKYFTALPKGPAFGNGRTARQTFESMVERHAGRVAQLTETSTDDLTLLYPEDLPELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ42</accession>
    <name>A0A7K2ZJ42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001127">
        <property type="protein sequence ID" value="MYW32279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="137"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="488" mass="52129" checksum="7FA7C5E4E41BD7DF" modified="2021-04-07" version="1">TVRGDEPGRTRPVGGTRRLPPRTPYALAVTDLRPRLVPLTADTPWLDPDPESIHALAETGAHSLIVVPLTLRGAVLGLVSLYRCGATDPFDEEDVSLAGTAATRAALAIDNARRYEREHVIASTVQRRLLPQAERHQAAVETAHVLLPGRDSGCWFDTIALSGARTALVVGGVAGEGLQSAIAMGQLRTVIQALAGLDLEPEEVLARLKETADRLAHERAALPPSDSLHGEELRAGCVYGVYDPFTRTCTVARAGHPAPLIVGPDGQRITVDAPEGPGLFADGSALFAPATVTLEEGSLLAFCTAELLADEHAEERITRTLARPGRSLQQLGDDIVYALPDDTRSAGAALLLARTGTVSDHRVATWDLAQERTTPATARLLVRDRLQGWGLDEDTVEATELIVSELVTNAVRYGTPPLRLRLLLDTSLTCEVHDGSTASPHLRHARTADEGGRGLFIVSRLAAHWGARHGPDGKVLWTEQDLPGSGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJD6</accession>
    <name>A0A7K2ZJD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_25090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001175">
        <property type="protein sequence ID" value="MYW32455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="22854" checksum="EDEC03749C7C8690" modified="2021-04-07" version="1">MTDEAPPSAPSPVRILLCDDHVVVRAGLLALLGSEPDIEVVGEAGSGEEAVALAARLTPDVVLMDLQLGEGIDGVEATRRIAAGGTVHVLVLTTYDTDADITRAIEAGATGYLLKAERPEELFAAIRSAAQGRTTLSAPVATRVMARMRSPRPTLTDRERDILAQLSQGLGNRDIARALFISEATVKTHLGRIYDKLGVDTRAGAVSVAKEQRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJI8</accession>
    <name>A0A7K2ZJI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001196">
        <property type="protein sequence ID" value="MYW32512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="24503" checksum="8AEE0CD90BB4EFFD" modified="2021-04-07" version="1" fragment="single">MVDDTWSSALHRLWQAASRAEEVAALADDVYAPLLATPGVHHVVGTRWDEKHVLRYMRALSAGSDTPVIVATTRSMPGAAVREPGGEPVVTRSAVDGMDGSVWPEAEFLRQAPGASVVACTFRLDQRGWAALALAVDGTADLSVVESRLTQAVDVIVACHTGILQRGREARRASDDALLAEASLQMDSSLDVEDTLRRVARIAVPAVADGALVHLLRGEGPEFVAATHVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJP7</accession>
    <name>A0A7K2ZJP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_25720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="40"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="355"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="389"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="595" mass="62093" checksum="A1EEF283CCF8C71C" modified="2021-04-07" version="1">MTVTDTPPAPAKLRTATGREATGWVAAHCRRAPWLTFSTVLTTVAGAALQVVPVLLLGRVVDGVVGGESRSVLVTVGVLMGAAALLGAAATAASTYLIGRLGAELLAQLRESAVRAVLGMPSARVEQVGRGDVLSRVGDDVAVLSKGIRQAIPTVFSAGVLVAIATLGMFGLDWRLGLAGACALPAYALALRWYLPRSAPLYRKQRIAQADRAQALISGLNGIDTVRAYRLEGDVREKVTAESWRVRNLGVEVFRFFGRFVGRENRAEFIGLVLILVVGYALLEADAATLGEVSAAPLMFHRLFTPLGAIMFTFDEAQKSGASLTRLVGVLGEPAEERLVGDASVAPAEAVLYAVTVEGLTFSYPDTEEPVLRNVNLAIPAGGSLALVGATGAGKSTLAALIAGIGTPQSGTVRIGSWDLAGLDEAAARSLVSILTQETHVFSGPLADDLRLAAPEASDEELTDALRTVGAAGWVELLPGGLHAPVGEGGERLDVTKVAQVALARLVLSRSPVVVLDESTAEAGSEGAAELERAVRAACAGRTTLFVAHRLTQAMAADRIAVLDAGRVVEEGTHEELVALGGMYARLWRAWREGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJQ2</accession>
    <name>A0A7K2ZJQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_25730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001200">
        <property type="protein sequence ID" value="MYW32578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="118"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="325" mass="32889" checksum="FE9DEF73F710D6A2" modified="2021-04-07" version="1">AVAGLGSLPLAYAAVVVAGIATPPLEGGLRALWPSVLKRQDQVHRAYALDAVAQEIMFTVGPLLVTLLVSLRSPAAALLVINAIGVLGALSVVLSEPSRSWRSAPREAHWLGALRSPGLLALLGAFFFVGLALGSITVAGVAYADDHGRESVYGWLMAALGLGALIGGLGYGARQWAGAPERRLRVIVGLLALGYLPLTLTPSVPVMTALAALAGVFLAPAIACSFIVVDRHAPRGTVTEAFSWLVTTFGVGAAAGTAVAGPAVELGSTAWSFGVAGVGGVLALVVLLATGKVLAAPVRDPAVVTGSENDRNGAVEPGFSTGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJV8</accession>
    <name>A0A7K2ZJV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001207">
        <property type="protein sequence ID" value="MYW32627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reductase_C" evidence="1">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15928" checksum="087ACE911FD23AF4" modified="2021-04-07" version="1">ALRTSDPHIYAAGDVAAVAHPLLGVRLRVEHWANALNSGPAAARSMLGQDVTYDRVPYFFSDQYDLGLEYSGWAPPGSYDEVIIRGDAGKREFIAFWLKDRRVLAGMNVNVWDVTETIQELIRAGQQRDPEALADPSVELSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL10</accession>
    <name>A0A7K2ZL10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">GT040_28160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001308">
        <property type="protein sequence ID" value="MYW33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="517" mass="54367" checksum="2235C97CBA80594C" modified="2021-04-07" version="1">MSVNKPIRRALVSVYDKTGLEDLARGLHEAGVELVSTGSTAGRIAAAGVPVTKVEELTGFPECLDGRVKTLHPRVHAGILADLRLDTHREQLAELGVDPFDLVVVNLYPFKETVASGASDDECVEQIDIGGPSMVRAAAKNHPSVAVVTSPERYADVLAAVKAGGFDLTARKRLAAEAFQHTAAYDVAVASWFVDGYAPADDSGLPGFLGDALTRKSVLRYGENPHQPAALYTSGTGGLAEAEQLHGKEMSYNNYTDTDAARRAAYDHDEPCVAIIKHANPCGIAIGDDVAEAHRKAHACDPLSAFGGVIAVNRPVTVELAEQVAEIFTEVIVAPAYEDGAVEVLARKKNIRVLRAGGAPATTVEVKNIDGGALLQVTDRLQAEGDDPANWTLATGDALSEAELKELAFAWKASRAVKSNAILLAKDGASVGVGMGQVNRVDSAKLAVERAGAERAAGAYAASDAFFPFPDGLEILTAAGIKAVAQPGGSVRDELVIEAAKKAGVTMYFTGTRHFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLG0</accession>
    <name>A0A7K2ZLG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001349">
        <property type="protein sequence ID" value="MYW33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025450">
        <property type="entry name" value="YndJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14158">
        <property type="entry name" value="YndJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="30009" checksum="42C58B9EAC9DF73B" modified="2021-04-07" version="1">MTVLVNAIVMLGMLLVVPAGLRLTGLRELDGIRRLWPLFAAPGAVALWLPRGPTATALASCYALGTVLLALLGARRVVRGRDLSPAGIALLTALVTPAVAALALVAERWGHELFGFELGILALTVPHFHFAGFAAALVAGLVCRVTEGPAGRFAALSVPLGTLLVLVGYFIGDWAELAGAVVLTAGMWTVGLLTWRLGHEEGRDRTTRLLLLTSAAVLVATMLLALSWAVGEATGLPHPTLTWMAATHGLGNALGFALCSLLAWQRIRTTHPSDSPHPSHPESRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLI3</accession>
    <name>A0A7K2ZLI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ORF">GT040_28995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001351">
        <property type="protein sequence ID" value="MYW33196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076967956.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001351.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="105"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="26667" checksum="A4B01EB8CB9DF170" modified="2021-04-07" version="1">MRHTRNAAVRQAVAWCYRGGSISAEPRINDRIRVPEVRLVGPSGEQVGIVPLAKALELAQEYDLDLVEVAATARPPVCKLMDYGKFKYESAMKAREARKNQAHTVIKEMKLRPKIDPHDYDTKKGHVVRFLKQGDKVKITIMFRGREQSRPELGFRLLQRLASDVEDLGFIESNPKQDGRNMIMVLGPHKKKTEAMAEAREAQAARKAERQGTTDAAPEGDTAEAPAEAAEAPAETPSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLM6</accession>
    <name>A0A7K2ZLM6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein GT040_29320</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_29320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001358">
        <property type="protein sequence ID" value="MYW33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="878"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="922"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="959"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="994" mass="109014" checksum="6761EBB17CAE4835" modified="2021-04-07" version="1">MPDRGGGPTGPRISVGRPSRRVRTLLMTLGVLAVLAMAFVMFAGFWTDWLWYRSVAYSSVFTTTLWTKIGLFLVFGLLMALAIGVNIWLAHRLRSPLSAMSLEQQSLDRYRMSVAPFKKWVLLAVTALVGLIAGASASGQWRTWLMYVNGVPFGTKDPQFKLDVAFYAFDLPWYRFLLGFGFAATVLSLIAAALTHYLYGGLRITSPGARATAAATGHLSVLLGIFVSLKAVAYWLDRYGLAVKSSDFKAAENWTGLRYVDANAYLPAKTILFFIAAICAVLFFATLWRRTWQLPVIGFGLMVLSAILIGGLYPAIVQKFQVQPNEQAKEAPFIQKNIEATRDAYDIDDAVMEDYSGQATTTDDTKLRAAANTAASYRVMDPNVVSPAFQQLQQRRNYYQFPKTLDVDRYKGEDGKEQDTVIGLRELNIQGLPKRNWINDHFTYTHGYGAIAARGTSTGTNPTGSPDFTESGLPSTGEFGKYEQRIYYGEKTEQYSIVGGPQKELDYEEDGEKTTSYKGDSGVSLSNTFNRAAYAVSFSEPQIMYSGAIGDGSRILYNRTPKERVEAVAPWLTIDGDAYPAVIDGRIQWIVDAYTTTNGYPYASRTTLGDTTADSLTTNQRAVVAQQNQVNYIRNSVKATVDAYDGKVKLYEWDTKDPVLKTWRKAFPGTVKARSEISQTLMDHLRYPQDLFKVQRELLTRYHVQDPAQFYSGSDAWQVPADPTTKDSGSVPPYYLSMKMPGQDQQAFSLTTTFTPRGRPNLGAFMAVNADAASKDYGTMRLLRVTSTVKGPGQVQSELNGNDDVAEFVRNLKGTDSDIDYGNLLTVPLEGGFLYIEPVYTRGGNQNYPLLRKVAASYGSKIVFENNLGDALNAVFGVDGDSDTTPDPSEPPGDTTKPPATGSDALKKAIADAQKAYNDGETALKEQDWPAYGKAQDALQEALERAAKAQPTGGAEGDKAGTPEKDDGADPAKKPDEKPDEGDGAAEQGGDQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLY5</accession>
    <name>A0A7K2ZLY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybaK</name>
        <name evidence="5" type="ORF">GT040_29910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001386">
        <property type="protein sequence ID" value="MYW33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="167" mass="17017" checksum="B4346732D662F443" modified="2021-04-07" version="1">MAKKPKKQPGGTPATVALTAAGTAFTLRPYDHDPASTSYGEEAAEALGVSPDRVFKTLVADVDGELTVAVVPVAGSLDLKALASAVGGKRATMADPAAAERTTGYVRGGISPLGQRKRLRTVLDASARTHTTICVSAGRRGLQVELAATDLAELTGAVFAEIGRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM19</accession>
    <name>A0A7K2ZM19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001387">
        <property type="protein sequence ID" value="MYW33386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="27782" checksum="918F96C9526B0E9F" modified="2021-04-07" version="1">MGATRYREIAESLRHAIRTGTYPLGSRLPSESDLSARWEVSRGTVRQAVALLASEGLIGSRQGARRVVLRQERRQSFQQLNSFAQWAQAMGCEVASRILARTLRTATDEEAERLDAEPGSQVLYVLRLRWLDGEPVMVERTVYADWVAPAVLELPEDCVSIMDSIAERADIVAHHGEHLIDAVAAGSEDARLLQVRRASPLLRQRHLTCTAAGRAIEWTDDRYRAGSVVFNVMNSAGAAPLERRAGPDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM48</accession>
    <name>A0A7K2ZM48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="15344" checksum="6F836866365F9ED2" modified="2021-04-07" version="1">MSETTQLPCLHTAFYCRDRSSIPVVRKFTRKALIEWEYEERAYDVLLCVTELATNALRHGVPPGRGFRVKISLERMEKVIRIELHDSGGGEVRMADGLPGVEDEGGRGLLLVSALADKWGVAERNPGKIVWCEFTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMJ1</accession>
    <name>A0A7K2ZMJ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">yidC</name>
        <name evidence="16" type="ORF">GT040_30965</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001435">
        <property type="protein sequence ID" value="MYW33567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="329"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW33567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="417" mass="46111" checksum="85C3C54FFE2E05DE" modified="2021-04-07" version="1">MDTIASLFSFITTPVSWVIVQFHKVYGALFGDDSGWAWGLSIVSLVVLIRICLIPLFVKQIKSTRNMQVLQPKMKAIQERYKNDKQRQSEEMMKLYKETGTNPLSSCLPILAQSPFFFALYHVLSSIASGKKIGAINQDLLDSARQAHIFGAPLAAKFTDSVEKLQSLDATLLDVRVVTAVMIVLMSASQFFTQRQLMTKNVDLTVKTPYMQQQKMLMYIFPVIFAVMGVNFPVGVLVYWLTTNVWTMGQQMYVINQNPTPGSKAQDAYLQRVLKTVDSRGQVRGRTQRRTVKAIVAKGPDRNDIERKFITGLSKKGLVAQEDGTVKKGEVVPEGEGAAAKRQQPKRQTKAKRQTATTAGAAAKDEPVAGSKTSLQKQDAPQDDKPTSAGKSASGSSRQAKSGQRKGPQRPKHPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMM5</accession>
    <name>A0A7K2ZMM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="88" mass="9741" checksum="09EE2F4AA6AC7C49" modified="2021-04-07" version="1">MSDPTVLYDVTEQVRDALTSAPLIGWTGDRHYDIAATHAASTALYEVADILRERAEVYAADGKHEAARALLDEADRLADRERTRPDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMQ9</accession>
    <name>A0A7K2ZMQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001434">
        <property type="protein sequence ID" value="MYW33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14073" checksum="C70D3C8BC0B58409" modified="2021-04-07" version="1">MTIRATNQPHARVIPLRPFPAPPGPAPAREPLWRDLVGDVLRRERLSQERTLKDVADAARISMAYLSEVERGRKEASSEVLAAAARALGLSLADVLELAQGELIRLSGARSRSTGQHGRPAGPLGTVRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN11</accession>
    <name>A0A7K2ZN11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VCBS repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001439">
        <property type="protein sequence ID" value="MYW33659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="948" mass="100537" checksum="2982E5E79BA6ADA0" modified="2021-04-07" version="1">MAAEAMASARATAEGEPVEVSSARTETGEVHAMPDGTMRRTEHTAPVRVKRAGQWHAINTDLHRSGARLAPKAAPGAVTFSPGGDRELATFTDKGRSVTLKWPDPLPQPQLEGPTATYPEVLPGVDLAVSAKLDGFGHVLIVKDAQAAAQPRLRTITYGLEADGLRVEKDEASDTLRAVTPQGQEIFSTSTPRMWDSSSTGTARRAALAQESDPGVQTAGLPLTLSPDALTLTPDQDLLNGEDTTYPVYLDPNFNGAKQAWTIAYSRYPSTSYWNGANWNGSYKDQPRVGYEKDTGGKSRAFFRLNSKGLGGVQVLSAQFQITNTYSWSCSGRSTELWLTGGISNQTTWSKQPSWSTKLQTKSFAYGYNSSCNARPVDFDAKVAAERAAAGNWADITVGLRSTSETDTYTWKRFNSNPKIIISYNRKPNTPSGMQTSPSTSTSTACNVAPYVTLGNTDVTLRAKISDPDGGTVKARFHLWPTGKHPNDAADGVLIINRDVQVTSGSMASTVVSKNDLKRYEGFGSGGRFSWKVSALDAHTSSGYTPTGGGCAFGFDSSRPSSPPGVTSTEFPNGDSGTWGAPARTEGSFTLASGGVSDVVKYTYGLNSNPPTTEATPSSAGGSVTVRLTPTHTGPHILYVVSHDGAGNKSDTQAYLFYASSPGTPEKPGDLNGDGHPDLYAVDSASNLRFYPGNGEGRFGARMDVSTTGQWAGSLITHRGDWTADGYEDLITRQSDGKLWLYPTDGLGRVDEETRQEIGQFATPGEPEYIDPASVDQLVSVGDMGADPDAAKVDFAAVIGDTLWYLPGYTGGHLDYGYPIADTGWKNMTLVSPGDLDGDGHTDLIARDTVSGQVWLHRGKPGPDGGTDPFSLADPATRTAYATGLPATTHPLMTATGDASGDGVTDLWSTHLVTGSGNLMFHPGRANGAAQPPLLVGPGGWHTIRSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN22</accession>
    <name>A0A7K2ZN22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_31915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001452">
        <property type="protein sequence ID" value="MYW33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35525" checksum="19D8C0CABDBC24EB" modified="2021-04-07" version="1">MSTVSTEAPPGADRTDGPRRSHAPKRRGPRRDKQWPAYVFLTPWMLGAAVLTLVPMAVSLYLSFTDYNLFEAPSWVGLRNYREMLTEDPRYWRSVGTTLLYVVVGVPLKLVLALGAALLLKSLGRGRSFYRSAFYAPSLLGASMTVALVWRALFNDGGTVPDVLGAIGINTGGWVGNPDLAVFAVVLLTVWQFGAPMVIFLAGLQQISPDLYEAAALDGAGRWRQFVSVTVPMLSPVVFFNLVLEMIQSFQVFTPAFAISGGSGGPADSTMFYTLYLYERGFTASHMGYAAAMAWLLLVAIGVVTLFLFRTSRSWVFYADEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN43</accession>
    <name>A0A7K2ZN43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001466">
        <property type="protein sequence ID" value="MYW33784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS_4" evidence="1">
        <location>
            <begin position="83"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="29912" checksum="7CAE4741E4DD3157" modified="2021-04-07" version="1" fragment="single">GWAVRRADAHEVQGRLMAAMDAPGRQVHEFALLRKDGSRVLVRTQSARVLGADGKPAGVYCAFSEVHAQIDLERAIALSEALLEDASWGVVLVDVDLRPTVVNAYASRALGGGRTTLLGRPLGELVVQGVDELEAALQHVLAEGAPGAPAEFWVTLRTAEGERRRCWRSGFLRLASPLAEEPVPLGVGWLFRDVTAAKLAQQEADRLRFRASQLHRAVRTASECEDPMEAVTSLLDFALAGFADHVLLDLTADGPTAGEVMEGERLVRTAATPSDAPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN89</accession>
    <name>A0A7K2ZN89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglycosylase SLT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001481">
        <property type="protein sequence ID" value="MYW33802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="121"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="27849" checksum="B2C05EA5D57B3358" modified="2021-04-07" version="1">YQESGWNPRAQSPAAAQGIAQFIPGTWATHGIDGNGDGKRDVWDPADAIPSAASYDCEIAGYVKKVPGDPTNNMLAAYNAGAYAVIKYGGVPPYKETQNYVKIIRSLEKSFARPVGRVAPSRQAAGAIYFAQKKLGTPYLWGGNGTPEQQGRFDCSGLTQAAYRTVGIELPRVANDQYNAGPHPSRDELLPGDLVFFSDDLTNSRAIRHVGLYVGGGYMINAPFTGAVIRFDKIDTPDYFGATRVTKDGAAALPTDLPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNH9</accession>
    <name>A0A7K2ZNH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_32645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001491">
        <property type="protein sequence ID" value="MYW33890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="340"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="524"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW33890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="709" mass="74883" checksum="E9DDA70C1D6A5A55" modified="2021-04-07" version="1">MSSTTELLKGAAELFPGEVVTQAHVRHLDLPSGAGRFALITLDNGLDHTKPTTFGPQSLANLNAAIDQVEKEAADGTITGVGITGKPFIFAVGADLKGVELLGRHEDALAIGKGGHDVFRRLSGLAVPTFAYYNGAAMGGGVEVGLHCAYRTVSTAIPAFSLPEVFLGLVPGWGGCALLPNLIGADRAVSVIIENSLNQNRQLKGKQVFELGIADAIFEGADFLEQSLIWTAAVLKGELAVERPEIDRGEGWDAAVARGRAIADSKVHGAAPAAYRALDIIAAAKDGDLSAGFDAEDQALADLIMGGELRSGIYAFNLVQKRAKRPAGAPDKSLARPVTKVGVVGAGLMASQLALLFLRRLEVPVVLTDIDQERVDKGVGYVHAEIEKLLGKGRINQDKANRLKGLVSGVLDKAEGFADADFIIEAVFEEIGVKQQVFAEVEAVAPAHAILATNTSSLSVTEMASKLKNPERVVGFHFFNPVAILPLLEIVRGEQTDDASLATAFGVARKLKKTAVLVKDAPAFVVNRILTRFMGEIQNVIDEGTPVEVAEKAVEPLGLPMSPLGLLELVGPAIGLHVSETLNRAFPERFTVSENLAAVVKAGKRGFYVYDSGAPVLDPEVAALLKQGDTVLTEEQTRDRVLDAVAQEIGLMLDEGVVAEAQDIDLCLITGAGWPFHLGGITPYLDREGVSQRVNGKPFLAQGVASVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNP1</accession>
    <name>A0A7K2ZNP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic dehypoxanthine futalosine synthase</fullName>
            <shortName evidence="6">Cyclic DHFL synthase</shortName>
            <ecNumber evidence="6">1.21.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dehypoxanthine futalosine cyclase</fullName>
            <shortName evidence="6">DHFL cyclase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mqnC</name>
        <name evidence="8" type="ORF">GT040_33120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33083"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="1.21.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.1" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001508">
        <property type="protein sequence ID" value="MYW33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046992">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00992">
        <property type="entry name" value="MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022431">
        <property type="entry name" value="Cyclic_DHFL_synthase_mqnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03699">
        <property type="entry name" value="menaquin_MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="56"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="399" mass="44119" checksum="FA3F6A8BFEB7D71D" modified="2021-04-07" version="1">MTEKADLQPVLDRAAEGGRITPEEALDLYRSAPLHALGAAADAVRRRRYAGTEHIATYIIERNINYTNVCVTACKFCAFYAPPKDKAKGWTRDIEDILRRCAETVELGGTQIMFQGGHHPDFGVEYYEEHFSAIKKAYPQLVIHSLGASEIEHMARISKVSAEEAISRIHAAGLDSFAGAGAELLPARPRNAIAPLKESGERWLEIMEIAHGLGVESTSTMLMGTGETNAERIEHLRMIRDVQDRTGGFRAFIPYTYQPENNKLKGRTQATLFEYLRMISIARLFLDNVAHIQGSWLTTGKEVGQLSLHYGADDLGSIMLEENVVSSAGAKHRSNRLEIIDLIRKADRVPAQRATTYEHLVVHDDPAMDPVDERVVSHISSTAIAGGTAHPELKLLNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNQ0</accession>
    <name>A0A7K2ZNQ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_33035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001505">
        <property type="protein sequence ID" value="MYW33967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="14886" checksum="4E7EAAF587388072" modified="2021-04-07" version="1" fragment="single">MSATETAIASAEAHSAHNYHPLPVVVASAEGAWMTDVEGRRYLDLLAGYSALNFGHGNRRLIDAAKAQLERVTLTSRAFHHDRFADFCTELAALCGMEMVLPMNTGAEAVETAVKTARKWGYRVKGVPDGLAKIIVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP26</accession>
    <name>A0A7K2ZP26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucarate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03323">
        <property type="entry name" value="D-glucarate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034598">
        <property type="entry name" value="GlucD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="3">
        <location>
            <begin position="181"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR634598-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="434" mass="46648" checksum="CFB135383BBD51D0" modified="2021-04-07" version="1">MHTTLVIEDVRLTPILVADPPLLNTQGVHQPYTPRLIVEVVTRGGVTGVGETYGDGTYLDPANALARALPGRTVTDLNGLFTLADEVCGDSRQAGDREADLRVAAGGLRGVRSAEKIRLSVVSAFEVACLDALGKALGLPVHALLGGKVRDAVEYSAYLFYRWAHHPQGGERDDWGAALDPEGIVAQARRFADTYGFASFKLKGGVFPPDQEIAAIRALAGAFPGRPLRLDPNGAWSVPTSLYVAEQLTGVLEYLEDPTSGTESMAAVSAATDVPLATNMCVTTLAEVPEAFATDAVQIVLSDHHYWGGLHRTRELAALCRTFGVGLSMHSNTHLGVSLAAMTHVAATVPGLAYACDSHYPWQTEDVITERHTFTHGRLTVSDAPGLGVELDRDRLAALHRRWLDDDGTHRERDDAAAMRGGDPQWVAPVIPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP35</accession>
    <name>A0A7K2ZP35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_33740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001543">
        <property type="protein sequence ID" value="MYW34103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509769.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001543.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="330" mass="35460" checksum="4C004D9E342ACE27" modified="2021-04-07" version="1">MALLSVEELSVTFTARGRKDATAVDGVSFDVDQGQVVGLVGESGCGKSVTSLALMGLLPRKGVRIGGRAEFDGQNLLGISERKLRDMRGSQLAMIFQDPLSSLNPVVPIGIQVTEILQRHRGLKGEKARKEAASLLDRVGIPDPDRRLKEYPHQLSGGMRQRALIAMAVACAPRLLIADEPTTALDVTIQAQILELLKELVDQEGTALLMITHDLGVVAGLCDEVNVLYAGRAVESAGRRELFAHPTHPYAHGLLGSIPRLDAPRGEPLNPIRGSINDKIAWADGCAFAPRCDHYTMECLTGTPELTEPRAAGHQVRCVNPVLPKAEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPI4</accession>
    <name>A0A7K2ZPI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fic family toxin-antitoxin system, toxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001584">
        <property type="protein sequence ID" value="MYW34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018516085.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001584.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13371" checksum="E3E7361DD5722263" modified="2021-04-07" version="1">MNLRIDLSWLLMVAEHKTPGDPQVVDWGALVAAVARHEAEIFGSAVYSDPHTRAAALLQLLLHVPALERSNAMFASAVAYGYLVASGLKVITSPEQVRDLALLVKQGKADVRAIADELRQWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPK2</accession>
    <name>A0A7K2ZPK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001590">
        <property type="protein sequence ID" value="MYW34301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="11474" checksum="E818B94C60010913" modified="2021-04-07" version="1">MTHLPTDVRAAFRLFAFYLRNGTLDVDLLGFDYWDALQHGSDLEMVFAIFSNVLEVDEHDRTVNDGDAQYRVAQWIRARQDPSYVVDPPFEPWETELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPQ7</accession>
    <name>A0A7K2ZPQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2690 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001600">
        <property type="protein sequence ID" value="MYW34354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021224">
        <property type="entry name" value="DUF2690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10901">
        <property type="entry name" value="DUF2690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="13536" checksum="0C83165F103FD1B9" modified="2021-04-07" version="1">AKAAPPAAPTSEAPTSEAPTEEPAPEQPAGVECQGAECAGQNPDEMGCGGDHARTVSTAQVGAARVEVRYSEVCSAAWARLTEAGAGDTVTITGGAAADAQNGAVTVTEAYTPMVAVRKAADAKACATLTAGTKGCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ08</accession>
    <name>A0A7K2ZQ08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001622">
        <property type="protein sequence ID" value="MYW34422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009956">
        <property type="entry name" value="Post-segregation_anti-tox_CcdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07362">
        <property type="entry name" value="CcdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="82" mass="8843" checksum="8075F8987D66B9FD" modified="2021-04-07" version="1">MSSTTRITVTLPSDQVAELRKLTDNVSGYVAEAVARQIRHQLLGDDLRRHEEEHGSFSDEELAEARAKIFGSAGTSTGADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ97</accession>
    <name>A0A7K2ZQ97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001636">
        <property type="protein sequence ID" value="MYW34546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509817.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001636.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="52"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="19168" checksum="3F0150BD4EBAA834" modified="2021-04-07" version="1">MMVGMAGLEGVDQPRPRSSATAARWTSGMDDEQAFKALELFGNPTEGEVRLPSRPESAATARRLTSCVVLRQWALSPQTAEYAVLLVSELVGNAVRHTGARVFGLRMVRRRGWIRIEVRDPSRGLPCLMPVREMDISGRGLFLVDKLSDRWGVDLLPRGKTTWFEMRISDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQC9</accession>
    <name>A0A7K2ZQC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001626">
        <property type="protein sequence ID" value="MYW34469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="459"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="818" mass="90829" checksum="009D234B985E2D17" modified="2021-04-07" version="1" fragment="single">MTDQGATEEGTRFPPGAQILVRDEEWLVRNTTTTDHDGERIEAVGVSEFVRDEEAVFFSGIDAVELLDPEKTRLVPDTSSYFRRSRLFLEAALRKTPLPQSERGLALADRFLLDPLVYQQRPAELALSMRNLRPRVLIADVVGLGKTLEIGLTLAELIRRGRGERILVVTPQSILEQFQHELWTRFSIPLVRLDSLGIQRVQRELPSGRNPFTHYKRVIISVDTLKNIGRYRHHLERIRWDAVVIDESHNLINPGSQRRALAEILAPRTDALLLASATPHNGDKRSFADLISLLDPAAIADRDHYDPAEDLGHLYIRRTKISPEVRDEMGTEWPDRGPTVSLHCAATEAEERVFAELAEHWIPTTQASTEFGTAAQDPVPVAVEPVFAYNLLKTFLSSHKALGETVTNRVASLQDRVRRAEEKGQLPDPAIATEQAALARLRQIVDGMGDGTAPGDSAKLDALVTQLKEIGVGPRSTTRAVVFSERVRTLTWLADVVPARLGLPVGADGTSKAVAVMHGGLSDEEQAKVLESFGLADTPVRLLFTGDVASEGVNLHRQCHHLVHYDIPWSLIRIEQRNGRIDRYGQKHEPRFHALILTSATPGAKDDRTVAEKLLRREEEAHKLDGTAEAVSGLYRAEEEERRLIKELVRGGTVEEFLDSGPAEEDTALADLFGQVDTVTEHELPARAELISLFDGDTADFVATALDEVYEERAADLIGLASGTDAQGGGYFSLSPSLAPDLLHRLKALPPSYLREQRVADRMLVTSDRALAQRKLDEARSSSTTMWPEVSFLTDIHPVVEWLTDKVLVEFGRQEAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQG8</accession>
    <name>A0A7K2ZQG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_36015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001636">
        <property type="protein sequence ID" value="MYW34538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="28"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="268" mass="28157" checksum="E2B65FF158D54ED9" modified="2021-04-07" version="1">MRTETTTATAPAATPGPGDARRRGPATAVLIAETRLFLREPGSLFWVFVFPSLLLVILGFVPAFRETQDDLGGRRVIDLYVPISILLAMITAGIQAMPPVLTAYRERGILRRMSTTPVRPSALLGAQILLHGAACLGSALLVTVVGRTAYGVALPGQLPGYLLALLLAVAAALSLGAMICAVTPTAKAATAVGSGAYLVMMFTAGVWLPVQAMPGILRRIVEITPFGAASQALEQAASGSWPGWIHLGIVALWTVAMGVAASRMFRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQL3</accession>
    <name>A0A7K2ZQL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diiron oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001650">
        <property type="protein sequence ID" value="MYW34607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="304" mass="34514" checksum="ACFA78ED73023F25" modified="2021-04-07" version="1">MSSSTVRPEDQDRLAEQDVARRLLDSSAKLSYDPATEVDWETPLDPDHHGASPEWSTLYGTAYWNELTDAQRKALTRQEAASVASTGIWFEMILQQMVLRDMYAKDPTDPRFQWALTEVADECRHSIMFARGAAKLGAPAYRPRRPVVELGRAFKTLAFGEAAYAAILVAEEVLDVMQRDWMRDERVAPFVRTINNIHVVEESRHMKFARDETRKRLRDAGAVRRQLNAVVVAIASYYIVTSMVNRDVYTNAGLDAQRARAEAKVNEHHKSLMRSSCSGLMEFLASARLLTKPALFFYKRASLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQL5</accession>
    <name>A0A7K2ZQL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ORF">GT040_36615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001675">
        <property type="protein sequence ID" value="MYW34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003967084.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001675.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="13228" checksum="5665B547F74CAC8B" modified="2021-04-07" version="1">MNAYAPILVLGALGAGFAIFSVVMATLIGPKRYNRAKLEAYECGIEPTPTPAGGGRFPIKYYLTAMLFIVFDIEIVFLYPWAVSFDALGIFGLVEMLLFVLTVFVAYAYVWRRGGLEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQM6</accession>
    <name>A0A7K2ZQM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001647">
        <property type="protein sequence ID" value="MYW34598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="193"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="542" mass="57252" checksum="AABF36E8D9466DD5" modified="2021-04-07" version="1">MPDGPLPVPPDTTPAPAAPGPALDDLSAREILGRLPAAVALLHGPDHRVAYVNEAYETAFGPRPSGVPAAEALPELAELSVLPLLDQVLRSGTARTVKSRRTAGGGSYTVTCTPVAAWDGTADKDDEKTGEKASGKTCEKDKETRSEGGVLVYAADVTDHAEAAERLRTSERRHRETAVTLQRSLLPQELEQPDDLRIAATYQPGGTDAAVGGDWYDVITLGAGRTALVIGDVMGRGVRAAAVMGQLRTAVRAYARLDLPPHEVIQLLDGLASEIDATQIATCVYAVHDPNEGQLVYASAGHLPMLVRDEDGTVSRAADPTGPPLGTGGWIHTSGTIALPPGSTAVLYTDGLVERRSEDIDEGVASLARALSGAKGSPQVVCDRLIRSLGVTAEHDDDVAVLVVQHPSRTGPHAELFHNAALDLLGGIEATPRARSFATGVLTSWRFPAELRDLGVLAASELVANSLQHGTPPMRLGLRRTDRRLIIEVTDGDDHLPRRRQAEPADEAGRGIEIIASIATSWGSRRTPGGGKAVWCEFALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQU7</accession>
    <name>A0A7K2ZQU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_36470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001658">
        <property type="protein sequence ID" value="MYW34629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="23962" checksum="9C57F08FA64AD164" modified="2021-04-07" version="1">MRAGDREVFGALYDRYAQSVHSHACRLTGDLSAAEDVMSETFLAAWRTREQIDPEGGPLRPWLLGIATNKARNHRRGVGRRLAFLARHPKPKETEDFAEASAGRLDHQRELAAVRAVLDRLRQPEREVLALCVWAGLDYAQAAVALGVPVGTVRSRLSRARTRLRGLAGEHLEREAREAREARESGRSGGSGWEPRRGRGEVGGRAAFVALPGEGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQW5</accession>
    <name>A0A7K2ZQW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001684">
        <property type="protein sequence ID" value="MYW34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="101" mass="10932" checksum="FA0EC969B57F2BCA" modified="2021-04-07" version="1">GPGALPDAQVRRWIEINGTRHQISRPTLVMGRSTDADVRIDDPGVSRRHCEIRTGTPSTIQDLGSTNGIVVDGQHTTRATLRDGSRIVVGSTTIVYRQAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQZ4</accession>
    <name>A0A7K2ZQZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511077.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001681.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8903" checksum="CE2EB8615BFAE7FC" modified="2021-04-07" version="1">MSFRISYAPPADDTLAKMRDGQSFRDEMARTLGREPYGHASSAVKSERDRREATVSGAIVLYYVSRSVLTVTVVRLVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR01</accession>
    <name>A0A7K2ZR01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001687">
        <property type="protein sequence ID" value="MYW34775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="26"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="592" mass="64046" checksum="4BFF173C51C3F6D5" modified="2021-04-07" version="1">MPQLPATGGRDVHTVRFPVGRPPATVDVLIVGAGPVGLAAATELTARGIRVAVVDRARTATLVRAGAMGHTPRVVEHFRRWGLLQRIREAWTYPPEWNRGTRLVTSLTGHELVPVPRPSFRGSGAPDHAADEALRRPQTVLQQVFLDHLAEHGVSVAGGWELQELAEDTEGVRGGVVDIDSGERRTVRAAYVLGTDGGSSTTRRLAGIDREGDHATEKRLRLIVRTGDISDRVGAAPSATSIVFNHRASGFLAAVSTREWRVYAGPYPLGHEPTEDELLETGRAAFGFDLELDLVSATTFYHATRIATTFRRGRVLLAGDAAHVRTPGGNLGEGIGDVANLGWKLAAVLAGHAPDTLLDSYDQERRPHNWRVAEHSLERSRRSQATLAEIRAGGIPDDADLGDEAVRRRAEIGERLRRDHAGGAGVTFDERYDASDVIWYEEGQLASEPGWRPDVYEDDPRPGHRAPDGRIDPHGSTLHDRIGTSFALLVLGEDPTGQFAEGGTRDRAVEDAFTREAAARSLPLSVIHLTDPDARAVYGTAYVLVRPDQHVAWRGSVLPDGGARAVLDRVLGRDRCGTAAEALGSVPARRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR18</accession>
    <name>A0A7K2ZR18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pup</name>
        <name evidence="7" type="ORF">GT040_37050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001682">
        <property type="protein sequence ID" value="MYW34738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515354.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001682.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02106">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="ARC ATPase binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="Deamidated glutamine" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="7920" checksum="1EFD8ECE9A098CB2" modified="2021-04-07" version="1">MATKDTGGGQQKATRSTEETEEQAQDAQASEDLAERQEKLSDDVDSVLDEIDDVLEENAEDFVRSFVQKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR74</accession>
    <name>A0A7K2ZR74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001700">
        <property type="protein sequence ID" value="MYW34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="13422" checksum="CB6E5A6CCE427BD3" modified="2021-04-07" version="1">MSPETAPRREVVTGEPRRVRPLPRYRTQAEIEEQTALGGAYVRSLMRSQLRAGLTVFAVLALVTGTLPLLFAALNSAALVWAVLGFATYPPLTLAAWWYVRRAERNERDFARLVEGRPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRB3</accession>
    <name>A0A7K2ZRB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mreC</name>
        <name evidence="6" type="ORF">GT040_37310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001688">
        <property type="protein sequence ID" value="MYW34789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="35681" checksum="D8F5BEB7B30D8DF0" modified="2021-04-07" version="1">MRDTRESRLLLVLLIAIAFALITVDIRGGEESPVDGARQAAATVFGPIENGVATAVDPVGNAIGAVRDSGKRHDRISALEQENAALKAKLGSDDRTNSRVRQLDAMLKNAGAGRYGIKGAEVIAIGAAQGFSWTITIDAGANDGIRRDMTVLNGEGLVGRVTTVGPSTATVLLANDPDFTVGTRMEKTDELGFATGQGSRPLSVQFLNGKAKVKAGDRLVTFGSSKDKPFVPGVPVGEVVRVDPSGGALTRTVYVKPYVGFTKLDIVGVVVQAPRQDPRDTVLPKAPVKAKPKPTPTVTVTVQPNGDLVDGSGKVVGNINENAGDGAAAGDQQPDNAANDLDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRD6</accession>
    <name>A0A7K2ZRD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001725">
        <property type="protein sequence ID" value="MYW34915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="20614" checksum="ED2164B512FC7401" modified="2021-04-07" version="1">MPLPDRRDLIADAALSTVASAGLRGLTHRAVDTAAGLPAGSTSYYFRTRSALISTCYLRLAELTVADVDRWQAEHEGTDPDSAAEVLAVLLHHWLTAGRDRQLARFELSLEAIRRPELRADLETAGLAARSRATALLAALGASRPAQAADLLVAWTDGLLYDRLAGAPAASRPAPDVTELTPVVRRMLAAALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRE5</accession>
    <name>A0A7K2ZRE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001694">
        <property type="protein sequence ID" value="MYW34819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA_3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23026" checksum="33CD490B1B1F40A8" modified="2021-04-07" version="1">DRVQAVIAERARMARELHDMVANHLSAVAIHSTAALSIDDPETSRNALKVIRENSVEGLAEMRRLIGLLREGGEDSAPAAAPTLASLDALVEQANTNGAPSGLVCALEDIREAGSEALPTPVELAAYRIVQESLTNALKHAAPGPVTVRLDLTGDVLAVEVTSVFGSRPGPTAPGSGAGLVGMRERVALLGGSFEAGCAGEKLWRVRAELPVREREMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRE8</accession>
    <name>A0A7K2ZRE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_38260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001733">
        <property type="protein sequence ID" value="MYW34970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="26014" checksum="60600DF092FB6EEA" modified="2021-04-07" version="1">MPEPRVPDPVNVLVVEDDATIRRAVQLALERYGYRVDVAADGLSALEAFRAGTYDLLILDVMLPELDGIGLCHRIREESLVPVLMMSARGDALDVVAGLEAGADDYVIKPVDTPVLVARIRALLRRATFAPSQSPPPDAPDHVLVFGDLTVDTLGMEVHRAGEPVPLTPTELRLLLEFASAPGSVLDRRRLLREVWDYGWEGDTRVVDLCVLRLRKKIGSGRIETVRGFGYKLVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRK7</accession>
    <name>A0A7K2ZRK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoadenosine phosphosulfate reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001727">
        <property type="protein sequence ID" value="MYW34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="42"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="155" mass="17182" checksum="D41C7895F656B519" modified="2021-04-07" version="1" fragment="single">MSAVTTTVSGDTANPYALSHLDSLESEAVHIFREVAGEFERPVILFSGGKDSIVMLHLALKAFAPAPVPFTLLHVDTGHNFPEVLEYRDRTVKKHGLRLHVASVQEYIDAGKLRERPDGTRNPLQTVPLTEAIQQHRFDAVFGGGRRDEEKARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRM3</accession>
    <name>A0A7K2ZRM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="10">PRA-PH</shortName>
            <ecNumber evidence="3 10">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisE</name>
        <name evidence="11" type="ORF">GT040_38325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PRA-PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="3 10"/>
    <dbReference type="EMBL" id="WWKE01001735">
        <property type="protein sequence ID" value="MYW34983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="90" mass="9889" checksum="2E11FBD9C03B3620" modified="2021-04-07" version="1">MGHKTFEELFAELQLKAAEGDPSTSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKEAAAEEISQLLYHVQVMMVARGISLDDVYAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRR3</accession>
    <name>A0A7K2ZRR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1918 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001736">
        <property type="protein sequence ID" value="MYW34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7566" checksum="03A213A5C56ECBDD" modified="2021-04-07" version="1">MEAHAGDRLLMHGRTVGQHDRVAEIIEVLGDGGAPPYRLRFPDGHEHLMSPGPDSVVQHIEAPRGRPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRX9</accession>
    <name>A0A7K2ZRX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Citrate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001766">
        <property type="protein sequence ID" value="MYW35057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="9933" checksum="1D70A2B48DAED4DD" modified="2021-04-07" version="1" fragment="single">FEAPPETLAAARRTVGALPAHSGSTDRLRVAVTAAAATDPLRFDLSPEAVLSSARSLIPTLVGALPVVGGASEAAGGSLARQLWPRLTARPADAPALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRY9</accession>
    <name>A0A7K2ZRY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inducer of phenazine A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001772">
        <property type="protein sequence ID" value="MYW35092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="336" mass="37596" checksum="ACAC4C7894348FAB" modified="2021-04-07" version="1">MKSQRELLTPQMLRYDDFDDRAETRYLPYLMYFHRADYRSATINTDRLGFRISHGATEQGSVADPPRGPVRLLAGSSTPFGIGATADTATMASRLWTRYAPSVPWLNFAGRSHNSMQELLLFLMHRELVPEIDEIVVFSGLNDLALARLPDAQRGDHGGFFNCGEYFDSMEELRASHRKPKRGFGRRPGGPEDAPHVVPPLADRIAYAVDLTSRHLAALRLLAGPTGARITYVLQPLATWVRESGPREERAIFGELDGISNFWELYGDIATLETGRRYADALQVACKEQDIRFLDLSPVVAESVKDDDWLYVDRAHFTDHGTEIVSGLLAESLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSE1</accession>
    <name>A0A7K2ZSE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001779">
        <property type="protein sequence ID" value="MYW35139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="50" mass="5391" checksum="70532224A16B8D47" modified="2021-04-07" version="1">VDRAGGRDWAQVCAADRMARAMHHLSRAVPDPDGAGDLLALAEFVTRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Y0</accession>
    <name>A0A7K2Z5Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000006">
        <property type="protein sequence ID" value="MYW27746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="59"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="30950" checksum="E0A80059CB0EAAB0" modified="2021-04-07" version="1">MYSPTPDDWQDANRARWDERVPIHTASDFYDLDAFRAGKDALRPFELAEVGDVTGKTLLHLQCHIGLDTLSWARHGAAQVVGLDFSEPAVETARGLAESLDLGPDRAAFVAADVYDAATAVPDSSYDIVYTGIGALNWLPDMERWAETAASLVAPGGFLYLAEFHPLTDTLDDGTGSVVTHDYFSREAWVDETPGTYADFDAPTVHNRSVEWQHPVGEVVTVLAAAGLRIEFLHEHDVSLFPRFGTLERHADGHYRFPADRPRIPLMYSLKATRPKPTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6U4</accession>
    <name>A0A7K2Z6U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VII secretion integral membrane protein EccD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000086">
        <property type="protein sequence ID" value="MYW28066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15129" checksum="13F8A836E4193F58" modified="2021-04-07" version="1" fragment="single">MTSRSELSRVTLVGERRRADIVLPSDTPIGQLLPEILQLLDDRAASRPLTRQLLTSDGSALPHDSTLASAGVSDGAVLRLVRIHAAPPAPVVHDVTDQVADTLDLQAWRWRPAARRVAAGASTVAFSVVAALLARREFPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z783</accession>
    <name>A0A7K2Z783_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000115">
        <property type="protein sequence ID" value="MYW28206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="543" mass="60000" checksum="249DED01D11DFA95" modified="2021-04-07" version="1">LVEYAAGAEVPAQVAGARPLRVLRDAFSDGVHLRNDLFSYQREVEEEGENSNGVLVLEKFLGCSTQEAAEAVNDLLTSRLQQFENTALTELGPLCAEKGLDPTQTASVLAYVKGLQDWQSGGHEWHMRSSRYMNGGGAGEAVAGFGMSAASIKFTLRSETARARSHSHLPYQHVGPSLVPDLELPFGTTLSPHLEGARVRLVDWARRMGILEAQPGVPGSHIWDEERIVAIDLPLCAAGIHPDASPEELDISSAWLAWGTYGDDWFPVVHGRSRDLAGARLANERLSLFMPLDGEAIPEPVNALERSLGDLWRRTAEPMDLGARRTFRSAIESMTESWLWELANQAQNRIPDPVDYVEMRRDTFGSNLTMSLCRLGHGRTVPEAVYRSGPMQSLENAAADYACLLNDLFSYQKEIEYEGEVHNGVLVVQNFFGVDYPTGVAIVHDLMKSRLRQFLHVAEVELPVLYDDFGLDAEAREVLAGYVLELKHWIAGILIWHRGCRRYREEDLRRGHGAPWHLGGPTGLGTSAAQVTRLMAELAGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z797</accession>
    <name>A0A7K2Z797_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPP34 family phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_02800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000119">
        <property type="protein sequence ID" value="MYW28227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="22416" checksum="1A5B18C028226AAB" modified="2021-04-07" version="1">MTTAKDLFIIAMDPRPERSVGQGDLSLALAGAELIDLIDAGAVTVDEDRIVPGETSAPQDGLLGEAAALLTRESPHERIEDWLWRRGRDLAAAYQAALEEDGELTRKRSGRLSFGSERVEPVDTPARRAAAERWEEREPVLAALASAVGVEGGRPDVEGGAPDEEPGLDDEAVTAVVTSVHDAVMELEAVRQRRTIENSAFANLWRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7D4</accession>
    <name>A0A7K2Z7D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000118">
        <property type="protein sequence ID" value="MYW28223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="12337" checksum="41EABEDE4AF19827" modified="2021-04-07" version="1">LLTTAARLASGDARPTLAHWAAGQQWVGTAGAVLVAHGCPAEAPPSLIRSSHLAAGYAAGVAQAHATALGLRSRPIGSWLQADLGAALGDAPGQDWIVHGLALAGPADPSVPAPPPLPGEEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z813</accession>
    <name>A0A7K2Z813_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000194">
        <property type="protein sequence ID" value="MYW28497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="371" mass="40430" checksum="E46AFDD6145DCB86" modified="2021-04-07" version="1">MNYEGVGAVVRTVGVEEELLLVDPDSGEARALSTAVLALAERDAEGESAFESELHRQQLEFATHPCREMGEIADAVQRWRAEASRHAADVGASVAALATSPLPVSPTIGTGERYDWMAERYGLTAQEQLTCGCHVHVSVESDEEGVAVLDRIRGWLPVLLALSANSPFWQAQDTQYASYRSRVWGRWPSAGPVELHGSAERYHEQVKALVGTGVLKDEGMVYFDARLSANYPTVEVRIADVCLDPADTVLLATLVRALVETAAREWRAGQPPLDTEVSLLRVASWQAARSGLEDRLIHPRTLRPEPAADVLQALVTHVRDALEDSGDLKAAQKALSALERRGNGARVQREILERTGSLRDTVAECVRITAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8C9</accession>
    <name>A0A7K2Z8C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000203">
        <property type="protein sequence ID" value="MYW28568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="15969" checksum="040F95FC908B9546" modified="2021-04-07" version="1">MEAELTALAASGATTFVGLMATEAWSQVRGRLARFLARGEDSEAIDAELEESREELVAARRSGDEGSAEDIAGAWRVRLRRALRDNPEAAGELRELLDELAPHQAPGPTVTVNNSTNGGTYYSQVIQGHDISGLTFHGGGAAPRPEPDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8J5</accession>
    <name>A0A7K2Z8J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_05005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000220">
        <property type="protein sequence ID" value="MYW28642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="277"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="352" mass="36406" checksum="4A87A71D49C7E97D" modified="2021-04-07" version="1" fragment="single">MPATTGTTTSVIVAGARTPMGRLLGSLKSFSAADLGGFAIKAALDRAGLGGDQVQYVIMGQVLQAGAGQIPARQAAVKAGIPMNVPALTINKVCLSGLDAIALADQLIRAGEFDVVVAGGQESMTNAPHLLPKSREGYKYGAIEMLDSMAYDGLTDAYENIPMGESTEKHNSRLGLDRTAQDEIGALSHQRAAAAQKNGIFEAEITPVEIPQRKGEPVVFAKDEGIRPETTVESLGKLRPAFAKDGTITAGTSSQISDGAAAVVVMSKAKAEELGLEWIAEIGAHGNVAGPDNSLQSQPSGAIRHALKKDGLAVEDLDLIEINEAFAAVAVQSMKDLGVTPDKVNVNGGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z903</accession>
    <name>A0A7K2Z903_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR02611 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000261">
        <property type="protein sequence ID" value="MYW28840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013434">
        <property type="entry name" value="CHP02611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02611">
        <property type="entry name" value="TIGR02611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16760" checksum="06CB4CE67F8B2D71" modified="2021-04-07" version="1">MNAESDERIEAAEKASPESAPGGTTKAEKVERELGSRAPGFIKASRPLHLSWQVGVFVVGLGVVVAGVLMLVLPGPGWLVIFGGMAIWATEFVWAQLVLRWTKRKVTEAAQRALDPKVRRRNIILTTVGLVIMAVLVGIYVWKFGLALPWTVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z942</accession>
    <name>A0A7K2Z942_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000267">
        <property type="protein sequence ID" value="MYW28856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="30456" checksum="35D4282AEB841029" modified="2021-04-07" version="1">MNGDLTRTFETPDGTVRWDVLGEGDPVVLLHGTPFSSRIWHEIAPALAQDHQVYVFDLLGFGQSEQREGQDLRLAAHTRVFTGLLDHWGLESPRVIAHDIGGAVALRALLLEGARYADLTLVDAVGCGDWGTGLFRLVRENAHLFEQLPVYAHEALAASHLRFASHAGYRPDVLAAHLDPWRGEEGRAAYYRQYRQLEQTATDEFQHLLGSVPVPTRIIWGREDGFLPPPFAEQLHGLIPHSELHWVEGAGHATPEDAPARLLALLTREFPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9C1</accession>
    <name>A0A7K2Z9C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_06540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000299">
        <property type="protein sequence ID" value="MYW28939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="145" mass="15758" checksum="ABC4D8E967395F3C" modified="2021-04-07" version="1">MTVTSDLARTLTEEAEAEGIATFVAAAVVTDADRILLVRRKPDDFMGGLWEIPSGHVDAGESILDAARRETREETGLTVISVDRYLGHFDYGNSRGTTTRQFNFAVTVAETGPVILTEHDLHQWVNPTGDLQGVTDGVRKVLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Q5</accession>
    <name>A0A7K2Z9Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF320 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_07255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000326">
        <property type="protein sequence ID" value="MYW29077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514626.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000326.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029853035" evidence="5">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="6">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="7436" checksum="0A24588621136EEB" modified="2021-04-07" version="1">MKYTKVAAVAAGTLMAMGAAAPAMADSGAEAIAAGSPGVLSGNIVQVPVHIPVNVCGNTVNVIGLLNPAFGNTCINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9R3</accession>
    <name>A0A7K2Z9R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000327">
        <property type="protein sequence ID" value="MYW29079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="429" mass="44709" checksum="F59322B0AA743A7F" modified="2021-04-07" version="1" fragment="single">CAELAPDGVVRLSGHRRTAADLLYGLFDATHLAPLHRPGPEELLALVRSIGAVVIVDDLEIGGAALDGLLEATPECAFLFGTTPDLTPPGVDAHLEEILLAGLGRAASLELLAKVVERPLTEDERNWAGDLWFESEGLPLRFVQAGSLLRQRDRLNTDPAAFDEYDYFEPRPDDAPPVPEAPTAETLDVPLPSLGEGAAPAVLLASRLSEAARETLRFTVALGGEVPHQAHLPALVGDTHADAALGELAGCGLLSPAGPRYRLAAGVLAQLEAGGYAEEAAAHARTAAQHYAWWVSHPSVTPQRAVAEADAIVAAMGRLVPDGEAGQASAAVLLARSAAPALAAGMSWGAWEKALRAGQEAARIAGEVAEEAYFHHELGVLALCSGNLDRARTELETSISMRGALADKSGAVAGRRALALVADRSGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA02</accession>
    <name>A0A7K2ZA02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000355">
        <property type="protein sequence ID" value="MYW29132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029893745" evidence="2">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="8437" checksum="A11B65632DC13236" modified="2021-04-07" version="1">MSKKSLRSVLAVAFSAGLVSVALGALSPEVAGVDGTVAVQSQARPPVDLAWDAAPAKLAEASTAAERGPDMGWDFAPTEKDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA69</accession>
    <name>A0A7K2ZA69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF501 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000369">
        <property type="protein sequence ID" value="MYW29233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21685" checksum="C82A1FD33DEA9897" modified="2021-04-07" version="1">METPPPQTESTKPTDADIAAFEQQLGRPPRGLRAIAHRCPCGNPDVVETQPRLEDGTPFPTTYYLTCPRAASAIGTLEANGVMKEMTARLETDPELAAAYRAAHEDYITRRDAIEVLEGFPSAGGMPDRVKCLHVLVGHSLAAGPGVNPLGDEAIAMLPEWWAKGACVTPCVPKDEDGWTVHESDGGHFAFRPVDGPSEGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA94</accession>
    <name>A0A7K2ZA94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_08420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000385">
        <property type="protein sequence ID" value="MYW29301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="412" mass="42782" checksum="4A38AC263E639F22" modified="2021-04-07" version="1">MDNAESSVVTVLFPLMREAMGLTSSALGTIVAVGKVVGMVSGIPWVLLARRYPRKVVLATCSGFWGVWVIAAGLSTSFTQFVLLYAIAAAGFAGAGPIALEILGDIYGDSRRGGATGLLYGGVALIAGVSAPLFGLLSGSADGWRYGYMASGTICLVVGLLVLILLDDPGPAGGGTRPALDAVERRARSLRSGLRELLATGTFRLILVQRLCSGQNVIMSFGVVFLVEERGFSTATASIVALPFALGYLTGTVLGGRVNDRVHRLRPRSGRIVMLQGSQLAFAVVACVTTQVAWGGGIAVYAVLFALLGLLQGQVPVVNRPLIMAVVRPELRALAFAVSVTTVEALAYAGYALLVGHLGDTVGLQKALLAVTVLLTTANALASAALYRPYARDRIAIAEPRTSGLGPRPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAD0</accession>
    <name>A0A7K2ZAD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000375">
        <property type="protein sequence ID" value="MYW29262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="14886" checksum="85F2A1276B82C375" modified="2021-04-07" version="1">YAAAVAALGLSPVAASPLQDAPSRSETDRFERTLEYLCEGVAGGDVTAAIVHSDADAIVLIPRLQARGVRVPEDLAVIAYDDEVASLADLPLTAVAPDKHAVGAAAAKLLLSRLGVSDEGPAARRHLDILPTLRVRVSCGAAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAS9</accession>
    <name>A0A7K2ZAS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">16S rRNA (Guanine(966)-N(2))-methyltransferase RsmD</fullName>
            <ecNumber evidence="4">2.1.1.171</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsmD</name>
        <name evidence="4" type="ORF">GT040_09185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.171" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000418">
        <property type="protein sequence ID" value="MYW29444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052913">
        <property type="term" value="F:16S rRNA (guanine(966)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="20691" checksum="FDB077F8808B2943" modified="2021-04-07" version="1">MTRVIAGSAGGRRLAVPPGTGTRPTSDRAREGLFSTWEALLGTLEGVRVADLYAGSGAVGLEALSRGAVHALLVEADQKAVRTVRDNVRTLGLPGAEVRTGKTEQIVTGPAPSNPYDIVFLDPPYAVTDDDLREILLTLRAQGWLTADALVTVERSTRGGEFGWPAGFEPLRARRYGEGTLWYGRAAATCEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBQ4</accession>
    <name>A0A7K2ZBQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000497">
        <property type="protein sequence ID" value="MYW29786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="89" mass="9892" checksum="99D9C69A9D4A74CE" modified="2021-04-07" version="1">MDELMRQRRVYGADHDDPHPGPRPGHDYRELVGGPLDGLLLDVTGWSERALREGAGLVTEIGAYGPGGRAEYGPRSIDGHQWDWRGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBS7</accession>
    <name>A0A7K2ZBS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000497">
        <property type="protein sequence ID" value="MYW29789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512798.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000497.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="8309" checksum="4E6CFF15D944DF33" modified="2021-04-07" version="1">MANPPIVIHRPTPSGGRRVTVHYEGRDEILGLAHSDHDVIVFLSEAGLEEADRILDNPVWVEWRGGRAHRYEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBW2</accession>
    <name>A0A7K2ZBW2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_10800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000492">
        <property type="protein sequence ID" value="MYW29755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="28836" checksum="021F4360779658AD" modified="2021-04-07" version="1">MSDPLKDDFLGSDRLTGTLSALGVRPGDVLLVHASLRALGPVAGGAESVLAALRRAVGGDGTLVVPSFTPENSDTSPHYRARVRGLDAGAREAVRASMAPFDPATTPASSVGALAETVRTSAGAERSVHPQTSFAAIGPAAGKLLAGHRPDCHLGEDSPLARLYEADARVLLLGTGYDTCTAFHLGEYRRPGPPLRTYRCVVSLRGVRQWWAYEDVALDDSDFAALGAEFEEAAGPGDVRTGLLGSAPCRLLRLRAAVDFATGWLTEHRPTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC30</accession>
    <name>A0A7K2ZC30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000545">
        <property type="protein sequence ID" value="MYW29920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="20965" checksum="F5AE66431E10076C" modified="2021-04-07" version="1">MSERKLRVAVIIGSVRSGRFGPAPADWIAAEAAKRDDLDVDVIDLAKAWLPDVLPATAETPAPQAVQDLAPWLDASDAFVIVTPEYNHSFPASLKNAIDWYVDEWKAKPVGFVSYGGTAGGLRAVAQLRQIFPGLHAVTVRDSVAFPDCREQFDVQGRPSDPGGPLAAATSMLDQLIWWGRLLRDARAEGAYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC45</accession>
    <name>A0A7K2ZC45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000521">
        <property type="protein sequence ID" value="MYW29882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="30"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="304" mass="32237" checksum="54EAF089AFD64371" modified="2021-04-07" version="1">MTDRSSSAARLQEVAADVYAYIQPDGGWCLNNAGLIAAGDRPALIDTAATEARSLALRDTVTTVAKAPRYVVNTHPHGDHTFGNRLFTDEAVIIAQEATRAEMDLAGLHLTGLWPDVRWGDIGVELPGVTFRESLTLHLGDTTAELMHLGTAHTKNDTVVWLPRQRVLFTGDIVMSGATPFCLTGSIAGSLDVIERLRALAPSVVVPGHGPVGGPELLDSTAGYLRYVQDLAAEGIAAGLGPLEAARETGPGPYAELLDSERLVPNLHRAYAEARGARPGAPLDIEDLFAEMITFHGGLPACHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC66</accession>
    <name>A0A7K2ZC66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000532">
        <property type="protein sequence ID" value="MYW29902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="13332" checksum="54038CDD0F513695" modified="2021-04-07" version="1">PDGAEPAPPRLMAMWDSVLLAYADRGRVLPEAYRRTVIRANGDVLPTLLVDGYVAGVWRPVAGGIEATAFHPLAEEVWEGLAAEARSLVGFLAGREPEVYRRYGHWWSRLPDAAVRVLPGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC70</accession>
    <name>A0A7K2ZC70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000547">
        <property type="protein sequence ID" value="MYW29954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6555" checksum="229FDC6D94BCBB88" modified="2021-04-07" version="1">MVISISLVVLLTILAVIFLRNGGLKLSHAIVCALLGFLLASTSMAPTIHDGIGATANLVSGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCN6</accession>
    <name>A0A7K2ZCN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="241" mass="26200" checksum="7C1790E5DDFA4F43" modified="2021-04-07" version="1">MTDQQRLLSYARSKAQEIQEQLTWTAAEYGGGFWEAHGPGEGLVHGRVVAALQFLREYAGFDSSWFTRAEQTWDSQGGNKSVATGAYYVGELLKGWADQVEAGITEVAGSQAREKVGAVSTDVMEQVRQLNEDDKAHPAAAIVLCGAALETALRATVEARALSLPERQRPSLNSYTQLLRSAGIFTAQDVKDADMCGGLRNSAAHGHFDDLSRERAGLMEQQTNLLLRKLSDLATVGDEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCS5</accession>
    <name>A0A7K2ZCS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000600">
        <property type="protein sequence ID" value="MYW30157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="37"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="32768" checksum="56E70C8D967B5741" modified="2021-04-07" version="1">MSEEIIRTLSVDGVRYSYRVLPHASDSGAPAAEPALVLGGALQGMYGWPQMDDHLGPAADVVTADLPGMGSADPLPPGPSADILRRAVLRIADDLGAPRLNLFGFSYGTAIAFGFAQRHPERVARLALGGVPVHIDEDQVECWERAREVLAGGDREGFAAMAADALMCLDPERNVHRRELARRYVRRSFLHALTHSPHATNSLYRALADRPDFSGGLSGVPALVFAGEHDTVTSPERQREFAATIEGSRFLTVPDSDHWVVLERAFEVAELVARFFTETEAEGQRVGAPVSLPRQAGARAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCZ2</accession>
    <name>A0A7K2ZCZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000613">
        <property type="protein sequence ID" value="MYW30227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030562185.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000613.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="16809" checksum="848FA100ACCA6112" modified="2021-04-07" version="1">MTDPTDHVPAELYSRIQQFYARQMGLLDDGRADDWADTFTEDAVFQEASRLNEPLRGRDAIRESSRARKKRLEADKLDFRHWLGMLTVTPREDGSLQTRAYALAMRVPAGGELDIFASVVCHDQLVLTDGTWQVRHRDLHHDGSGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD00</accession>
    <name>A0A7K2ZD00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000616">
        <property type="protein sequence ID" value="MYW30240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="6479" checksum="22A397BC3F42D633" modified="2021-04-07" version="1">MPEFRQPGWTRGIAPLDEGAGGEVFGGASPVAATPAIMATAGAVVIAFAAGVVARELAGGNVELPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDD8</accession>
    <name>A0A7K2ZDD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000661">
        <property type="protein sequence ID" value="MYW30380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6265" checksum="EF783DCBE8024CDA" modified="2021-04-07" version="1" fragment="single">MTDAQETAADSSLRTTGGAPPDDVAPAPIPLLEPREGIPPVVASDDALARVVAAFAAGTGPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDF4</accession>
    <name>A0A7K2ZDF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_14060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000661">
        <property type="protein sequence ID" value="MYW30381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003965521.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6213395"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="220" mass="22936" checksum="0674A47FF43D8019" modified="2021-04-07" version="1">MSVLLEQPASLVAYRPNKPTAMVVVADPRVRSTVTRHLWALGVRDVIEASSIAEARPRVGNPRDICIADVHLPDGSGLTLLSETRAAGWPNGLALSAADDIGAVRNALAGGVKGYVVTGTRTNIGHPTRPGVAPIGANAARMHRRPPGSPSHPGGYRELSGREVEVLRLVAEGQSNKAIGVSMGLSALTVKSHLARIARKLGTGDRAGMVAVALRTGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDM9</accession>
    <name>A0A7K2ZDM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_14030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000660">
        <property type="protein sequence ID" value="MYW30375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="327" mass="35132" checksum="6DB5564BCC8F894E" modified="2021-04-07" version="1">MITVRGLARQFTVRGRTVDAVKGIDFDVAAGELVGFLGPNGAGKTTTLRMLTTLLRPTGGTATVGGCDLLTDPQGVRRRIGYVAQGGSTWPDSRVAEEIELQARLYGLSRADARRRGTLLAEQLDLAGLDQRPAKTLSGGQRRRLDIALGLVHDPALVFLDEPTSGLDPQSRANLWEHVRRMRAEQGMTVFLTTHYLEEADSLCDRILVTDHGTIVAEGTPDELKARVAGDAVAVDVADRAAEAAELAEQLPGAEEVTVARDTVRFRVPRGDSALPELLRALDGRGILMTSVQINRPTLDDVFLSLTGRSLRDSEAAPPAMEATHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDV8</accession>
    <name>A0A7K2ZDV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000713">
        <property type="protein sequence ID" value="MYW30534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="23503" checksum="B8D5C08289FD14C3" modified="2021-04-07" version="1">MLLLPQTNQLRALHTAIRDKNASVRDFEVYSRRIIRLLLEAGLDLLPFEKREVTTPVGETYHGLEFTPRVCGVSVVRAGESMEAELRDMIPGIRIGKILIQRDKRTKQPELFYKHLPDDIGSGHVLLLEPMLATGGSALAALDVLRDAGVPEENVVLINFLASPTGLERVSDAAPDMKIVTSSVEDGMNEHAFMVPGIGDFGDRFFGTVPTVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDW4</accession>
    <name>A0A7K2ZDW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane plasmid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_15000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000714">
        <property type="protein sequence ID" value="MYW30550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043760">
        <property type="entry name" value="DUF5706"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18967">
        <property type="entry name" value="DUF5706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="15412" checksum="E60B7F23DF0F19CE" modified="2021-04-07" version="1">MSSDRNLDAACATVSGEIARTDSKASLLLAFDGAVLAGLASVADKNLPVFTKAVGGLAVLALAAAAVLLLLVVRPCLTVPGRPAPGTFPQWAHLEENELQEAMDQDHRPARVKALSILAVRKFRRLALAVDVILAALALLTVAAIGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE31</accession>
    <name>A0A7K2ZE31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_15190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000718">
        <property type="protein sequence ID" value="MYW30586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="58" mass="6408" checksum="D4CA15FD2A0EB05A" modified="2021-04-07" version="1" fragment="single">MTAVPPPYTVRRAVEESDLAACFQVRKEVFVGEQNVPEEIEYDAYDPTAVHVLAVAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEA2</accession>
    <name>A0A7K2ZEA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen debranching protein GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glgX</name>
        <name evidence="4" type="ORF">GT040_15685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="176"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="709" mass="80230" checksum="D7D247D996F6C5A0" modified="2021-04-07" version="1">MQVWPGHAYPLGATYDGAGTNFAVFSEAAHRIELCLLHDDGSETAVELRETDAFVRHAYLPGIMPGQRYGFRVHGPYEPQNGQRCNSAKLLLDPYARAVSGKIEWGESVYGYPFGKPDARNDLDSAPHTMSSVVVNPYFDWGDDRRPRTDYHRTVIYEAHVKGLTMLHPGLPPELRGTYAGLAHPEVIAHLTELGVTAIELMPVHQFVQDHRLADMGLANYWGYNTIGFFAPHNTYASWGDRGEQVLEFKQAVKALHQAGIEVILDVVYNHTAEGNHLGPTLSFRGLDNASYYRLTDDQRYYMDTTGTGNSLLMRSPHVLQMIMDSLRYWVTEMHVDGFRFDLAATLARQFHEVDRLSSFFDLVQQDPVVSQVKLIAEPWDVGEGGYQVGNFPPLWTEWNGKYRDTVRDLWRGEPRTLAEFAGRLTGSSDLYQDDGRRPLASINFTTCHDGFTLHDMVSYNDKRNDANGEGNRDGESHYRSWNCGAEGETDDPEVLELRGRQMRNFIATLMLSQGVPMLSHGDEFARTQKGNNNAYCQDNELAWIHWPDPDAPDDEFRRNLLEFTRSMVWLRRDHPVFRRRRFFHGRPVEGTHDELSDIAWFTPEGEEMTQQDWQAAHAKAMTVFLNGQAISEPGPRGERITDDSFLLMFNASAETLEFAVPVDHGEQWQVVVDTARPEGVPPGTGPKVAEGEQLTLIGRSLTVLRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEB5</accession>
    <name>A0A7K2ZEB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029529993" evidence="1">
        <location>
            <begin position="33"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="95"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="503" mass="54039" checksum="65414B9CB1A0B5AF" modified="2021-04-07" version="1">MTRQRGIRRSAALAIALGLGLSGSLGTGPAGAQQKEGSTVRWGDCPEDVAAEAAPVVLKCATVFVPKDYADPGGDSIELMISRLASTDPGKRRGTLMLNPGGPGGSGLSQPAFLANRGIPSEVLDTYDVIGMDTRGIGRSAAVTCGFTPEGPYFANIPPYAVDDAAVTARAEAVEKVAEQCANRDKGGVLPHLTTANTARDLDRIREALGEERTSFLGYSYGTALGAAYASMFPERSDRIVLDSNIGDTHLDRDGMRRYALGVEQTFPDFARWAAARHDSYGLGRTVAQVRRTYFTLAERLDKEPVDGFDGNVLRQLTFGLLFKEVQYAKLAQHWQALKSDDAEAVRTAGARGAAADTPPSMDNQLSVFLAVSCNDVKWPTGVDTYRKGVAEDRERYPLFGAATANITPCAFWPYAPAEEPVAIDDDGPRNILLVQNLRDVPTPHVGGKLLRQKFADRSRLVSVDDSGHGVYVYGDNPCALNTTTRYLVTGEMPARDTLCRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEH1</accession>
    <name>A0A7K2ZEH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000757">
        <property type="protein sequence ID" value="MYW30757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="43"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="22086" checksum="B5AE471A01DD348E" modified="2021-04-07" version="1">MEGNFRDAAPEGADEGAGRTGPDHVARIQAEWARERPDVDVSPQAVIGRLHRLGHLLTARLDVVYRTHGLSEGEFDVLAALRRAGEPFERAPGELAAHTMVTTGAMTKRIDRLQRAGLVTRRRSAADGRGRVVALTPTGRSLIDRAFTEHMRNERRLLDALDPRESEELERLLTGWLARVEPVGGPATAPRTPSGPARREGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEP5</accession>
    <name>A0A7K2ZEP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_16260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000761">
        <property type="protein sequence ID" value="MYW30788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="26435" checksum="0A687DCB29CA6D1C" modified="2021-04-07" version="1">MGPSGGVTRSTLRQQIADALRDEVLAGRLRPGREFTVKQIAEQYGVSATPVREALFDLSAQGLLASDQHRGFQVHEFTISDYRAMVEARSLVVEGIFRRPADQVAVRPEALAPIRRRAAEAVRAAKGGDLDVLIGYDLRFWRELGAFVLNPYITAFLAKLRVQAWVFAVHRLRGEHADEHVLWFGHEELVEAIAGGDRGEVLAVMQTYYAHALAWADHLEAREAREAQKGRERPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZER4</accession>
    <name>A0A7K2ZER4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000759">
        <property type="protein sequence ID" value="MYW30775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="433" mass="46646" checksum="6CC1294EF6FB0E2F" modified="2021-04-07" version="1">MTNPSSATPAPPAGGGGGCPMGSGNGAVPLSGPGFHTEPHALYRSMRRDHGPVVPVELPGGFPAWLVIGYRELHQVTSDGELYPRDVSLWNQWEHIPPDWPLLPMVGAPMPSIYFTAGAEHRRHVEMVVPALEAADPFEIRQHCEQLADRLIDAVCSRGTADLVAEFAEPLPVLVLARLVGFPDDEGADIAQVLKDLADGGPGAQKAHLRFGEHMHRLVAAKRAHPGDDVTSRMLAHPEPFTDEEYALDLMAITAAGHLTTADWIGNSTRLMLTEDQFADALSGGRHSVAEAMNEVLWEDGPTQILAGRWASRDARLGGQDIARGDMLLLGLGAANADPHIRQQVTDQVVRSGQGGNSSHMAFSHGEYRCPFPAQEIAEIIARTGIEVLLDRLPDLELAVPATELVRRPSAFLRGMTALPVRFTPVRTTGDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEX2</accession>
    <name>A0A7K2ZEX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000776">
        <property type="protein sequence ID" value="MYW30882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="211"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="452" mass="48375" checksum="F02C1F6AE6929861" modified="2021-04-07" version="1">MQDGSSKGGLRAAFGGLTTRGRSFLAAGVAAAVCAYVLGQADLLRVGLLLAVLPLVCVIVLYRTRYRVTGTRRLTPSRVPTGSEARVHLRMDNVSRLPTGLLMLQDRVPYVLGPRPRFVLDRVEGGGRREVSYRVRSDLRGRYPLGPLQLRLSDPFGMCELTRSFSAYDTLVVIPRTVPLPALRLAGEASGYGDGRQRSLASAGEDDIIPRGYRHGDDLRRVHWRSTARYGELMVRREEQPQRARCTVLLDTRQAGYVGAGPDSAFEWAVSGAASALVHMLERGFAVRLLTDDGNAVPGSGSDGFAGSTQESADSAGLMLDTLAVVDHSDGGGLSRAHDVLRGGNEGLLIAFFGDLDEEQTSVAARMRQRTGAAVAFVLDSASWSGGMELLLGPPPGRAEARLRQLREAGWIVVPVPPGAELPALWQLAGQMRTDTQATGNGGSTGFPGGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEY3</accession>
    <name>A0A7K2ZEY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15489" checksum="F93E393B8338AC7D" modified="2021-04-07" version="1">MTAAQELSAPAPEPVLREDRVDYTPTARSVSLSRHRAARLVLQWGHPGMAGDAALVVSELATNALLHGAIRGRLFRVHLTLTEFVLRVAVSDPRGERLPCLQQPDGDDCYGRGLLIVAQLADRWGVEPRTVGKSVFAELSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFM1</accession>
    <name>A0A7K2ZFM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000849">
        <property type="protein sequence ID" value="MYW31099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029860403" evidence="1">
        <location>
            <begin position="34"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="99"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="430" mass="47050" checksum="4A3ABE9323C0FE96" modified="2021-04-07" version="1" fragment="single">MVTRVSSRTPRPGRRLRTLLASGAAALALTAGAVVPGNPLGPAPSEARADDGRTTLTVAVAQSVDSLSPFLAQRLLSTSIHRLMYDYLTNYDAKDNKAIPGLATAWEPSADKLTWTYTIRPDSKWSDGQQATAEDAAWTFNKMMTDEGAATSNGSFVGNFEKVTAPSKDKLVIRLKEPQATMAALDVPIVPRHVWEKVGDFSKFNNDKDFPVVGNGPFILTDYKVDSFVKLKANKDFWRGSPKFDELVFRYYKDQDAAVAALRKGEVSFVAGSPSLTPAQSASLENAPDIKVNDAPGRRFFALAVNPGARTKDGRKFGDGHPALLDQKVRHALFMAVDRRTIIDKVFQGHAVEGEGYIPPRFSDYFWKPSAGQKLAYDPAKAAALLDEAGYRRNGAGKRVGKDGKPLNFRILCHATDPNDKAIGKYLQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFM2</accession>
    <name>A0A7K2ZFM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC subunit UvrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">uvrA</name>
        <name evidence="15" type="ORF">GT040_18200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000859">
        <property type="protein sequence ID" value="MYW31151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="467"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="504"/>
            <end position="511"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW31151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="808" mass="86249" checksum="BC8ED7C3D9E67467" modified="2021-04-07" version="1">MHSPHDPYVRVRGAREHNLQDVNVDIPRDTLTVFTGVSGSGKSSLAFGTIYAEAQRRYFESVAPYARRLIHQVGAPAVGEITGLPPAVSLEQRRSAPGARSSVGTVTTLSNSLRMLFSRAGEYPAGAERLDSDAFSPNTAAGACPECHGLGRIHRTDEELLVPDPSLSIREGAIAAWPGAWQGKNLRDVLDTLGYDVDRPWCELEAKDRAWILFTDEQPVVTVHPVRDAGRIQRPYQGTYMSARRYVLHTFADTRSRTLRAKAERFLTSVPCPVCGGSRLRPEAMAVTFGGRTIAELAALPLSALAEVLTRAGAGGEETARVLTGDLLARIGTVTELGLGYLSLDRTAPTLSSGELQRLRLATQLRSGLFGVVYVLDEPSAGLHPADTESLLGVLGRLKEAGNSVFVVEHQMDVVRRADWLVDVGPLAGEHGGRVLHSGPPEGLAEVPESATRRFLFPGDGRGPAPVREPRTPTGWIRLSGVERHNVRGVDAAFPLGVFTAVTGVSGSGKSTLVGQVLAGVLADREAGEEAAGAGERFCAAVSGLEAVDRLLQVDQKPIGRTPRSNLATYTGLFDTVRKLFARTETARERGYTAGRFSFNVSGGRCETCQGEGFVSVELLFLPSTYAPCPDCHGARYNPETLEVTLQGLTVAQVLDLTVESAAHFFSGTPAAERALATLLDVGLGYLRLGQPATELSGGEAQRIKLASELQRTRRGHTLYLLDEPTTGLHPADVEVLMRQLHGLVDAHNTVVVVEHDMAVVAGADHVIDLGPGGGDRGGRIVATGAPREVARSAESRTAPYLAKALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG13</accession>
    <name>A0A7K2ZG13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000880">
        <property type="protein sequence ID" value="MYW31297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="17572" checksum="36CB3AD4C0F7F575" modified="2021-04-07" version="1">MTTPQTTAAVPATGTGPGVGGPKQSGAAGGTTTVGRGATGASEPAATRGRTSIADTVVVKIAGMAAREIPGVYDMGGGLSRTLGAVRDRVPGGRPNVGRGVKVEVGERQTAIDLDLVVEYGVAITDVARDVRENVIAAVERTTGLEVVEVNVTVNDVHLPEDDDEAAVTETRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG64</accession>
    <name>A0A7K2ZG64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2516 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030566729.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000907.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="11851" checksum="51CFAA5213AB3C79" modified="2021-04-07" version="1">MLLSAFGSLLQLLYLGMLVLAVVAFVFAATAREDAYRAADKKKKSFWLIILGVAVAVNLLIPFLFLQLAGVVASIVFMVDVRPALKEVSGGSGGGRRGGSSSDGPYGPYNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGA0</accession>
    <name>A0A7K2ZGA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000899">
        <property type="protein sequence ID" value="MYW31338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029680536" evidence="2">
        <location>
            <begin position="31"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="413" mass="43162" checksum="992EF16848C5BC23" modified="2021-04-07" version="1" fragment="single">MTCPSCRQELPSTARFCSSCGTPCAGPAAAAPAPVAPPAEDERKPVTVLFCDLVGSTALSGVLDPETLRAVTLRYFEAMSAQIVARGGTPEKFIGDAVMAVFGVPVVREDDARRALAAALGMRRALDALNEELYASLGIRLTTRVGVNTGQVVAGSDATARQALVSGEVVNIAARLEQNAGPGEILIGPQTLLAAGPTVTAEPTGPLQLKGKRDGVEAYRLLALGADDPELLRRFDAPFVGRTTELDALGRSLDETVREGLPGLLRVTGEAGIGKTRLVREWLTRRSGAGAFAYGAGRCRTYGDHGTLAPLADAVRSLLPHTHAHLTAPGDEATDDAMALLSGGLLRDGTPNAPFEDMCAALTVVLKRTARDRPVVLVFDDWHAAAPLLARTVDRLTGDAGPARVLVICAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGC0</accession>
    <name>A0A7K2ZGC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000912">
        <property type="protein sequence ID" value="MYW31404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="137"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="419" mass="44644" checksum="443418E424870FCC" modified="2021-04-07" version="1">AGAPDTGLGARRPHRADAPVGPGEAARIREQHAAAEDWQRLLTRIRGFDGFTHFLLPPSAEQMLREAKEGPVVLLNVDPLRSDALVVSAEGIELVPLGVTEGQLAHTARRFLAAVSVGADEPRARRKEASATVFDILEWLWDAIAEPVLETAGLTCPIPEGTPRGAVPRLWWSASGPLAHLPLHAAGHHRAADGRSVLDRVASSYTPSIRALRHARQAPAARGGGGPFLAVRRPTGTGGRDGASVAEVEAMARTVAGLRTVEGEDATVGRVLAELSSAATVHFACHGLSDAEDPSRSHLELADGRLGVLDVARRHLPHAQLAVLLACHTARTDRLPDEAIHLTSAFLTAGYPQVVGALWEATDLVSVRMADHLYRALRTYGGGLDVTDTARAVHGIVRELRARHPASPQVWAPYVHTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGG9</accession>
    <name>A0A7K2ZGG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000915">
        <property type="protein sequence ID" value="MYW31426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="8"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="510" mass="55578" checksum="4810BFFE276E68CF" modified="2021-04-07" version="1" fragment="single">MSTAPTLVVIGGGPRGTGVIERIAANARELYGDLPLDIHLVDPYPAGGGRIWRPDQSPLLWMNSMAEDVTMFTDETVELAGPVVAGPALHAWAEDVRAGRVTPDAEPAVLAEIRGLTGQDFPSRRLQSAYLRWTYERALAALPPSITVHEHRTTALSVTGPRGSRQRVRLKDRTEPLIADLVVLTVGHLDAEQGPEQAELNDFAARHGLIHLPPDFTADTDLTALPAGEPVIVRGFGLAFIDLMVLLTEGRGGRHENGVYVPSGREPVLYVGSRRGVPYHSKIGYTWTGERPPLPRYLTPEWADELLSRPGPLDFRREVWPLVAKELGHAHYHRLFTAHPERTILDPEVFDAKYAAADPGSPELADLVAGAVPDPADRLDLEALDRPLEGVTYESGEALQEGLRDYITADLTRRHDPDHSTDLAVFLGLLSAYAQLIRLGDIGNWWHGFFSYLASGPPGPRLEQLLALSRAGVVRFLGGSVAVEADEERGVFRASAATVPGEHIEARALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGI9</accession>
    <name>A0A7K2ZGI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000921">
        <property type="protein sequence ID" value="MYW31446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="249"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="335" mass="36764" checksum="9D48DDC5696492CD" modified="2021-04-07" version="1">MLRIHFTPDDLTRVRVARGPDFLWEITNSIQTLQRHDGEGVFGAWRRWVRPRLPEDRRLLSPLLPPYGYSPDFLTPTCGDRTTLRAAVDALLGTPRPRLRTELTLLARSRRLPGWTRALAEGDAGTLARLGDALHSYQAQVLVPHWRRVRADVEADRSRRLRSLMDGGTEGLLTSLGPDVRWRPPVLEVACPVDQHLRLDGRGLVLQPSFFCWPVPTTLADGALPPVLVHPIHHTPGWASSRDGGGGHDSLGHLVGRTRAELLRATRNGCSTVEAARMLQVTHPAVSQHMNVLRAAGLVTTVRDAGRAFHLATAEGLALLATEDRGSGPVGGDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGU6</accession>
    <name>A0A7K2ZGU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_20020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000933">
        <property type="protein sequence ID" value="MYW31499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15143" checksum="F512BB6465F501E0" modified="2021-04-07" version="1">MTAKVSYGSVEVGTELPAQSFPVTRETLVRYAGASGDFNPIHWNEKFAVEVGLPDVIAHGMFTMAEAIRVVTDWAGDPGAVVDYGVRFTKPVVVPNDDKGALIEVSGKVAAKLEDNLVRVDLVAVCDGKKVLGMSRAVVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHJ3</accession>
    <name>A0A7K2ZHJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent Clp protease ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_21690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001021">
        <property type="protein sequence ID" value="MYW31820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="98"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="26192" checksum="F27A8B942FFA4E65" modified="2021-04-07" version="1">MTQPLPATPSVRLDDLIEAIKKSNPDALEQLSGAVIAADHLGDVADHLIGHFVDQARRSGASWTDIGRSMGVTRQAAQKRFVAKKGGEASDLDPSQGFGRFTQRARNVVMASHNEARATRHAEILPAHLTLGLLAEPESIAARVLTGQGVSPDALRTAATLALPAAADEVPELIPYDADAKKVLELTFREALRLGHNYVGTEHILLALLEFEDGSGLLNGLGLTKEATSTAVESAVAEAAAALRQQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHN2</accession>
    <name>A0A7K2ZHN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001028">
        <property type="protein sequence ID" value="MYW31854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="18085" checksum="EE80241188EF589A" modified="2021-04-07" version="1" fragment="single">MNDRQNPYGHDPYYQQPQIIGYDEYGQPVYQQQGQQYDPYAAQQGQGQAQDTGYGYDPYGQAQQPQAYDSYARQQHPQQDQGGQGTDQGYGQSQGQGYGYGGYTDYGYTTGQQPAAVDTGQWNIPQQAAAPAPEQAQQHTPQPAARPTREQAPERQPATEEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI25</accession>
    <name>A0A7K2ZI25_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Big_10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_22180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001052">
        <property type="protein sequence ID" value="MYW31909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="4">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="257" mass="27879" checksum="ECDE340FD29355DB" modified="2021-04-07" version="1" fragment="single">TSVTVTDAEGHRLAGRAAADGRSWVSDRKAVPGTAYTVKAATRSSGGTARSTGAGFTTAPADKVNKVDWRPGTGSTVGVAQPVSLVFDHPVKNRAEVEKQLRITTSNDTEGSWGWIRDWSGRDRVDWRPRTYWKPGTEVTLKAELNGTDSGAAGGWFVRDYTTAFTIGDRQIVEVDLDRHQLSLVRDGRTARRIPVSGGTPGGDKRSWRGTAVLMAKEGTINMNSETVGLGDAYDKMVDHSMRLTWSGMYAHAAPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI39</accession>
    <name>A0A7K2ZI39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001066">
        <property type="protein sequence ID" value="MYW32016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="543" mass="60678" checksum="529813ED1B02A4D2" modified="2021-04-07" version="1">MGTVTDPAKLCDLFLRRSTLQDDKTTLHAHERDLRERAVREGLAVRKVWKEELSAFKAGVKREEFDSAISAVLAGEVRHLLVWKLDRLSRRGMGQVGQVLDQFDSKGARLLAHMDGLDSSIPQHRGLFAWLAEQARSESYNTSTRTRRTKAEKKFTGAWPGGQPPYGLRVRKGKTATEHHPKEYATSRRIADGLLADKAAGTIADELNAEGLTTRRGGRWRSSTITQLAHSPAWAGLMPVHDRYTDERGRERWRATDEPLTGPEGTPVRVGAGVITVGERARILAALRSRTSEGLATGRRGKPAAQSLLSGLLKCGRCGGGMTKGGPQYRCYRRVNMGKSACQGMTVLVEEIDSVLSAAFMSRVTSFTDTHELFQELARRWLSYKDPETDTRRTELTLALDNARSRLNALDDAFYVQGRFQGSEGQHRYEQMRGAIAGQISSVQNELTKIGTATDLMILRDCDLLNLAWQEADLAQARSLLRVVLHSVRLLPPDGPGKRCSWYQLYARCCFHWVGEQPQPLKLDMRRLDGVTRYLPEDLERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZID9</accession>
    <name>A0A7K2ZID9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001093">
        <property type="protein sequence ID" value="MYW32111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="12005" checksum="99730DC9ECBC6D87" modified="2021-04-07" version="1" fragment="single">MVLPCLDEAAALPWVLDRIPDGWRAIVVDNGSTDGSAKLARSLGAHVVTEERRGFGAACHAGLLAAEAEFVCFCDCDGSLDPALLAGFVRRIADGECDLLLGRRRPEGRGAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIG8</accession>
    <name>A0A7K2ZIG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001108">
        <property type="protein sequence ID" value="MYW32150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="73" mass="7893" checksum="73D89E10686D7D2B" modified="2021-04-07" version="1">MTRLSVRLPGYECSMVLWGKRVGVAVAYGALVGAVSRLWKDTWSDSLTFGISMAVVMLGVASAMDIRKRAGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZII2</accession>
    <name>A0A7K2ZII2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="502" mass="55250" checksum="28A1C9F2570339A4" modified="2021-04-07" version="1">MSAPTVPRPQQAGPPKTPLPPPPVSEADAAKARKSIAKLDEVLAMVTKALLTLGGGALIFTCVNVTLFGISHEIPWYIAWMLDPLASLALITVLYVDGVLAEHGGDYKPGGWPFLLRWTAGLSTWVMNCWTSLYPDGHFHFIPQKPDAGGILLHSVAPALLILLAEAATGYRKYATRRRGELNAVIAQFETAKATEREAAEKRAREEAEREAAAKREEAEREAAAKREAAEREAARREREEIARLENERRAAEIEAADRTRRAEIEAERERLALTERSAEIEASRRKTEAEIEDRRRREEWEREQAERDREATRQAEIVKAEAQAEALRKEAEAQAEALRKEAEAAAEAERIRAEAEARALEEAEKLKRQRALERAAAKARGTSESAGARASISAGRPSESGVALSAVPALTASENGGRIPREVREKQRDEAERYIAKCSLSGIAPDLERLGNQYGKGETWVGDRVRAAKKRLAEEDGFEESVIADALDVFEDDDSDSAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIL1</accession>
    <name>A0A7K2ZIL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001108">
        <property type="protein sequence ID" value="MYW32155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="127" mass="13632" checksum="9402D742AB570182" modified="2021-04-07" version="1">GGRPAKPPRPKWWPAAVLAQVSMTLLQVFGGLWLLGQIVGVLEPGLVVPALIMLAGVVGGPLVEWSCAAAIRGPARRYGQDAERRLREAAAGCGRARVLDPVSAELARYREVRERYVAVTEFSTTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIP4</accession>
    <name>A0A7K2ZIP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001113">
        <property type="protein sequence ID" value="MYW32222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="335" mass="36119" checksum="287F3B7209B3B20C" modified="2021-04-07" version="1">MDLDVFVTAHRTEWDRLDHLLRRGRRLTGAEADELVVLYQRTATHLSLIRSTTPDPLLTTRLTQLVARARATVTGTRKTSWRDAARFLTTGFPAAVYRSRHWWVPTAVLSTLVAALLGWWIGTHPEVQAAIAAPDDLRAMTRPGGEYETYYSSHPAASFAAQVWTNNAQAAAMCLVLGAFLCLPVVWILFLNMLNLGVGIGLMSSAGRLDVFLGLVLPHGLLELTAVFVAAGTGLRLGWTVIDPGPLSRRTALAQQGRAALGMAIGLALVLFVSGLIEGFVTPSGLPTWARITIGIAAELAFLAYVYILGRRAVRAGDTGDLTAVERSAELPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIT6</accession>
    <name>A0A7K2ZIT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001118">
        <property type="protein sequence ID" value="MYW32247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="25084" checksum="BBC305361D158860" modified="2021-04-07" version="1" fragment="single">MTPHVTVGVDESPESLAAALWAAEEASLLDVPLHLIHTEEWPVTAEVPPLSAESLVERYETLLRATADRVRDDRPGLDVTTGMARGRAPAELTAAANEAEVTVLGSRGLGGVVGFLIGSVSLAVVGRARRPVVLVRSGAPPSGAGSGDAGPGIVLGVDIEQPCDPLLAFAFGEAARGDEELRIVHSWSPPPAYGYTAVPDPGVGSGPGRKVTEGLAEMVRPWRSKFPAVRVTEQAVVGPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ34</accession>
    <name>A0A7K2ZJ34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2437 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001151">
        <property type="protein sequence ID" value="MYW32344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030569692.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001151.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="28136" checksum="7E2008D2E7CB7838" modified="2021-04-07" version="1">MRIARFSIDGNVAFGAVEGQGTVESGDLVLDIIKGIPYADFELSGTKVPLNKVRLLPPVLPNKVVAIGRNYAEHAAELGHEVPDAPITFFKPTTSVIGSGDAIEYPSFSNDLHHEAELAVVIGRMCREVPRERVKDVILGYTCANDVTARDVQAREKQWARAKGFDTSCPLGPWVETDLDPHDLTIQATVNGEQRQLGRTSDMVRSIEDLIVHITEAMTLLPGDVILTGTPAGVGPLHVGDEVAVTIEGIGTLTNKVIKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ36</accession>
    <name>A0A7K2ZJ36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001153">
        <property type="protein sequence ID" value="MYW32358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="25559" checksum="14A8BB1415077979" modified="2021-04-07" version="1">MRVVSLVPSLTEAVAVTAPGLLVGVTDWCTHPEDLTAARIGGTKNPDVEAITALAPDRVIANEEENRAPDLAALRAAGLDVHVTEIHTLDQAFTELDRVLTTGCGLTRPRWLDEAEEAWADLPAPTASPRPAVVPIWRRPWMVLGRDTFAGDLLARLGVRNVYADHAERYPRIPLDELNASGAELVVLPDEPYRFTADDGPEAFPGLPAALVDGRLLTWYGPSLLQAARELPSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJG4</accession>
    <name>A0A7K2ZJG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001183">
        <property type="protein sequence ID" value="MYW32474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="28109" checksum="DC95452483C7EFD5" modified="2021-04-07" version="1">MEVTWWGHATCTIEDSGVRVLTDPLFVRRFAHLRRRRGEVPPPQAALAEVVLVSHLHSDHLHLPSLSRLAEGTRLVVPSGAVAAVPGLRTLLRRRRLVVTEVRAGETVRVGEVRIRAVPALHDGRRLPVGPRKVPALGYVVEGEARTYFAGDTGLYDEMAEAVGSVDVALLPVGGWGPYLGHGHLDPSRAAEALTLLEPRSAVPVHFGTYWPIGLDGVRPHEFHGPGDEFVRQAGIRAPEVAVHLLSHGERVRPEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJI4</accession>
    <name>A0A7K2ZJI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="45"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="210"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="360" mass="37789" checksum="1B4FECD970192432" modified="2021-04-07" version="1">MSATPPPGPDDQDDVPGRIMSGEMAEQPAMLRRVLDQGAPRIREVAAEIAARKPRFVLLTARGTSDNAALYAKYLLEIRLGLPCGLASMSTTTAYGAKPDLRDVLVVTVSQSGGSPDLVASTRAAREAGAVTLAVTNNPDSALAAVSEFHIDILAGPEKALPATKTYTASLLSLYLFVEGLEGVDGTEAASALPDLAGAILGRRAEVKALAARYRFAERMVITSRGYGYPTAKEAALKLMETSYIPALSYSGADLLHGPLAMVDNISPVIAVVTDGRGGEALQPVLDRLRGRGADLFVVGPKAQVEAASAGFSLPTSGVPEELQPILEILPLQMLAYEVTIARGQDPDSPRALAKVTETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJZ4</accession>
    <name>A0A7K2ZJZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_26155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001216">
        <property type="protein sequence ID" value="MYW32661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="98"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="239" mass="25244" checksum="010122E5233008CA" modified="2021-04-07" version="1">PEGPGAAPSGWVLDGVQSAVPWAQVADRIAVPAHTGEGRAVLALVDPARRGVTLADQVSTSGERLAEMRLDGVRVEARELIAAPGAWEWLRDLLTTGTCALALGLGERVLAMTAEYTGKREQFGFPVATFQAVAVQAADRYIDLRAMEVTLWQAAWRLSTGAGGPLPAAGDIAVAKIWASDGVRRIVQTAQHLHGGFGADTDYPLHRFHAWAKQIELSLGPAAAHEEALGDLLAAHPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKU4</accession>
    <name>A0A7K2ZKU4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_27730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001298">
        <property type="protein sequence ID" value="MYW32960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="361" mass="37718" checksum="B11666C920A40886" modified="2021-04-07" version="1">MNDSSWGAPQGAGYRGAPEMGVAPAGPAYDAHEAQQTRPMPNVPDDPDAGRDAQSRANRDGDAAHVGGPLFRDEMPQEPMSTPLPSPPQKKRAGRDLRAAIGVGVGLGAVIVASLFIVKAVFVGVIALAVVVGLWELTSRLQEQKGIKAPLIPLAVGGAAMVVAGYARGAEGAWVAMALTALAVLVWRMTEPPDGYLKDVTAGVFAAFYVPFLATFVAMMLTADDGHWRVLVFLVLTVVSDTGAYAVGWRYGTHKLAPRISPGKTREGLLGAVAFAMVAGALCMEFLIDGGAWWQGLLLGLAVAVSATLGDLGESMIKRDLGIKDMGTLLPGHGGIMDRLDSLLPTAPVFWLLLVLFVGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL83</accession>
    <name>A0A7K2ZL83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001316">
        <property type="protein sequence ID" value="MYW33101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="16304" checksum="9343B2D0A7E5048D" modified="2021-04-07" version="1">MTETPQRNSPDSGSGKSPLSKRGGGDPGTRGRTTIADGVVEKIAGMAARDVVGVHAMGSGLSRTFGAVRDRVPGGGKSVTRGVKAEVGESQAALDLEIVVDYGVAISDVARDVRQNVVSAVERMTGLEVVEVNIAVSDVKLPDEDDDEDDGESQRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLK3</accession>
    <name>A0A7K2ZLK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SigB/SigF/SigG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_29100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001353">
        <property type="protein sequence ID" value="MYW33216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="49"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="21643" checksum="0AED4F4FC0CEC04A" modified="2021-04-07" version="1">IGLIKAIDRFDLSREVEFATFAVPYIVGEIKRFFRDTTWSVHVPRRLQELRVDLAKAKEQLSAELDRDPTVKELAAHLDLPEEEIIEGLVAANGYSAGSLDTPSADSDSGQEQRAYADVLGEADPGMETVENLHTLAPLLEQLDDRERRIVQMRFGAEMTQAQIGAELGVSQMHVSRLLTRIVKQLRKGMSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLX1</accession>
    <name>A0A7K2ZLX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001374">
        <property type="protein sequence ID" value="MYW33326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="124"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="374" mass="40438" checksum="88697BF3CED39273" modified="2021-04-07" version="1" fragment="single">TTVAKVTASHWPAAHRRAAAAGQPGGPEQLRLQWLTALEVRGIRPYLDQQRMLTPAARTPKKRAAPVVRQLRGGDRSAAARTRVVLEQSFGQLPSMEGPFTGRRAELAKVAQWVHAARAATQTRPVVVVLHGDPGSGRTTLAVRAAHALKDQFRGACVVDLRGQVDGESPLPTRDALLHLLNRLGAPREQLLFRDGTTPGAAGGTQPYGKSAAEQHVRRLGELYHQHLTGMPVTIVLDDATDAEQVRTLIPERSDSLVIVTAREPLELPEDIPAWVHHLPVGPLDAAGAEELLREVAGGEEAGPYDYPATDAVVELCGGLPLALRVAASSLGERTRSALAEDLRAYGPVSPVDRALWLRYTDQNEAARRLLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMD7</accession>
    <name>A0A7K2ZMD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YccF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001413">
        <property type="protein sequence ID" value="MYW33516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561948.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001413.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="130" mass="14127" checksum="9CADD98D0D13B2B7" modified="2021-04-07" version="1">MNTILNIIWLVLCGLWMFLGYLLAGVLLCITIIGIPFGVAAFRIGVYALWPFGYTVVDRRDAGSPSCVGNVLWLVLAGWWLALGHITTGIALCITIIGIPLGIANFKLIPVSLLPFGKEIVRTDQPFAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMI2</accession>
    <name>A0A7K2ZMI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001435">
        <property type="protein sequence ID" value="MYW33575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="33664" checksum="434510CD363CF01C" modified="2021-04-07" version="1">MTSTTGTAQHPEISEISDLTEGLLTPSRAGEIRDHLAECELCAEVRASLEEVRELLGALPDPEPMPEDIAARIDAALAAEARPGSPADGTADDSRATAVSREDADVSRETASADTGGTSSVTPPTGSSPAHPAGHPQGSTGPGRNRARRRRRAVFLGTACGAALIGMSVFFLQNLSSPSDSAGAAADRAVSASESATHSYSQESLETKVQDLLAGGAGTEDFSGQKQAPSTDEQAVPEAEPPDTKASRSPLVAPAVAVPPCVQQATGRTTPALAIDEGTYQGTDAFLVVLPHPSDPTRVQAYVVASSCVDTAPGSTGRLLLTEAYDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN15</accession>
    <name>A0A7K2ZN15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_31585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 9"/>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="804" mass="87863" checksum="E08516E2A04AA351" modified="2021-04-07" version="1">MTIAPADPVSATESAASTTSGEGTNDGPGTALLRTLTDLTVDLPDTDPGRVAASALRGRNARSDEAELRSLATEAAAGLISEDPAYSKLAARLLTRTIADEAASQGATSFSASVAVGHREGLIADRTAAFVELHSKALDELVERTLAEGADDRFGYFGLRTLHSRYLLRHPITRQVIETPQHFMLRVAAGLAEDESVRALDEVAALYGLMSKLDYLPSSPTLFNSGTRHPQMSSCYLLDSPKDELDSIYDRYHQVARLSKHAGGIGLSYSRIRARGSLIRGTNGHSNGIVPFLKTLDASVAAVNQGGRRKGAAAVYLETWHADIEEFLELRDNTGEDQRRTHNLNLAHWIPDEFMRRVDADTEWSLFSPADVPELVDLWGDEFDAAYRAAEAKGLARKTMPARELYGRMMRTLAQTGQGWMTFKDASNRTANQTAEPGRVVHSSNLCTEILEVTNDGETAVCNLGSVNLGAFVANGSIDWDRLDSTVRTAVTFLDRVVDINFYPTEQAGNSNSRWRPVGLGAMGLQDVFFQLRLPFDSPQARALSTKISERIMLAAYEASCDLAERSGPLPAWSETRAARGVLHPDHYDTELNWPERWDALRARVAKTGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETLSGEFLQVNAYLVDELKKLGVWDARTREALREASGSVQGFAWIPEDVRALYRTAWEIPQRGLIDMAAARTPFLDQSQSLNLFLETPTIGKLSSMYAYAWKQGLKTTYYLRSRPATRIARAASGQASAAAPIPVQQASAPDADAIACSLENPESCEACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN33</accession>
    <name>A0A7K2ZN33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001450">
        <property type="protein sequence ID" value="MYW33740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="424" mass="46217" checksum="9E7180DEDC3295A3" modified="2021-04-07" version="1">MAGERRRTAVVGSGVAGLTAAHVLHKAHDVTLYEADDRVGGHAHTHELGASDGRVHRVDSGFIVHNRRTYPHLLRLFDELGVATQESEMSMSVRCEGCGLEYAGARGPAGLFAQPRSALRGPYLRMLAEVTRFHRAARALLELPESPATDMTLGEFARRGRFSAYFHAHFLTPMVSAVWSCDPVTALRYPARYLFAFLAHHGMLTIGGSPVWRTVTGGSRAYVERVVKQLTAVHTATPVRAITRHADGVELTTEDGTTTPYDAVVIATHPDQALRLLADPTDAERDTLGVFTYSRNPTLLHTDTTLLPRSRGARASWNYLMPSCAADADRVTVSYDMNRLQRLDSPETFVVTLNGSDRVDPESVRARMVYEHPVYTPESVAAQARLPALSGAVTAYAGAYHGWGFHEDGCRSGAEAAAALGVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNA1</accession>
    <name>A0A7K2ZNA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="411" mass="44031" checksum="9951D24F6C5DC05B" modified="2021-04-07" version="1">MTGPLVLIEPYADRLGGHHQRTLVGLAQARPGSLVIAPRGVALDTVAALREADAQLVTSPARRPAAVLLAASQLAAGLSCAGLRAFRSRRWPRRLRRFPHQVTLIARCLTEASALRTARRLEPDAEAVVILSASEGLHGAAALLGGLPHLRFVHEQVTTEDASVRFLGRLARRGERQTVAVCPTQAVGDQLMAAFPGLPTVVRAFAVDDGRRLTDAERVGGRTALDIPTGEAAVSLIGGWWPYKDIGVVDAALTRLKRPLHLVVTGTPLDEAVLVRWRGLSNVRLHYVPGPVSEAVLRLVYAAADAALVARHPGIGKESGLVMDAARLGVPLVVSDHDPDLTARLSGRPWALTFTNSTPDALVEALHEVIRRPPERPGPEVPHLLGMWSAAGQADFLALTFASLRTKDHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNE5</accession>
    <name>A0A7K2ZNE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001490">
        <property type="protein sequence ID" value="MYW33883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029500470" evidence="2">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="209" mass="22539" checksum="A707B4E4560BB971" modified="2021-04-07" version="1">MVTGLGTPGVAATAVAAPMGITAPVSAAPADDEPVEGEPVEGEYEEDLPIPGEPPEVKFPDNEPDTPDGLECKPGWFFKITQNKKNTMSVKYRTFVENKKNYAVDFKFTSKKSGTTEAGASVTISADIGVKILGSIKAEVEANAKKSWTSEIGIEAYGRVKAKSTVNGDYGIGKENVYGYKYHLGSACQKSNKQYMTAWAPYREGWVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNR0</accession>
    <name>A0A7K2ZNR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001506">
        <property type="protein sequence ID" value="MYW33972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="283" mass="29437" checksum="F74EA5ED1F939CE0" modified="2021-04-07" version="1">MSADIGYFAAFLGGLLALVSPCSALLLPAFFAYSIDSTSRLLARTGIFYAGLATTLVPLGAAGSYAGRLFYGHRDALVTGAGWLIIALGVAQIVGLGFASKRIAALSGRIRPTTAFSVYALGAVYGLAGFCAGPILGSVLTVAAVSGSPVYGGLLLAVYALGMAVPLFVLALLWERFDLGRRTWLRGRTVQLGGRFRLHTTSLLSGLLFIGLGALFLVYDGTTALPGLLGVDASFAVEQWAQKLGERVSDAVLLGAVVLVVLLALGVRAWRRREPAVKEAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNS7</accession>
    <name>A0A7K2ZNS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001511">
        <property type="protein sequence ID" value="MYW33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015611831.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001511.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8539" checksum="E012090B7386FE47" modified="2021-04-07" version="1">MGTQQEKDELYALDISGVEWLSAPGTEDVEERVEIAHLPGGAVAMRSSLDPDTVLRYTEAEWRAFVLGARDGEFDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNX3</accession>
    <name>A0A7K2ZNX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-5' RNA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001505">
        <property type="protein sequence ID" value="MYW33969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="20868" checksum="7DAD058AE2A43349" modified="2021-04-07" version="1">MGTVTLGVSIAVPEPYGSLLQERRASFGDPAAYGIPTHVTLMPPTEAEAADLPAIEAHLDTIATAGRPFPMRLSGTGTFRPLSPVVFVQVVEGASACSWLQKRVRDASGPLVRELQFPYHPHVTVAHGISEEAMDRAYAELADYEAAWTCGSFALYEQGADAVWRKIRDFPFGSGGNAPAVPAQGGYSVDAPSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPC1</accession>
    <name>A0A7K2ZPC1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GT040_34305</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001564">
        <property type="protein sequence ID" value="MYW34211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="14">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW34211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22577" checksum="0DD8F1A10616210D" modified="2021-04-07" version="1">PRRALRLHGAAQAITERHGGDVPSEHGQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARAANGIQYPPNATTAAERKLARALLPDEDERAARWAAATMELGALVCTARNEDCDRCPIASQCAWRLAGKPAHEGPPRKGQTYAGTDRQVRGRLLAVLRDALTPVPQAALDAVWEEPVQRARALDGLVADGLVEPLADGRYRLPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPE3</accession>
    <name>A0A7K2ZPE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001565">
        <property type="protein sequence ID" value="MYW34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="10958" checksum="31C61B1C8BDC460A" modified="2021-04-07" version="1">GDTWPVAAALLPATGSQYAAMAVGTCGLLALRMLDPRTTLAIQVVFSLTTVAFLAGGYVVGGVLGAAWGLFLGSLCKAAATWTRVARLRRRTPAPEETVTAGASPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPE6</accession>
    <name>A0A7K2ZPE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_34280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001562">
        <property type="protein sequence ID" value="MYW34207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="157"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="368" mass="38590" checksum="31A875412D4F05C4" modified="2021-04-07" version="1">MRDVLLIALFAFLGAAAAGLLGAFVLRLLRHRSLVVSVTVVAGVAVTAMLAGTLTVAWAMLLSSHDLYVVTTVVAMAAVVSLATAVLLGRWVAARSRELTLAARSFGDGGTFAAPAGQPTAELAALTRELAATSAKLDSSRERERALETSRRELVAWISHDLRTPLAGLRAMAEALEDGMAPDSGRYLRQIRTEVERMNGMVGDLFELSRIHAGSLTLAPARISLYDLVDDALAGAGPLARERGVRLVGDRIEEAPVEVDGKEMSRVLGNLLINAIRRTPADGTVALSAHRSEGGVVLSVTDGCGGIPEEDLPRVFDTGWRGSHARTPPAGAGLGLAIVRGIVEAHAGRAEVRNVQGGCCFSVTLPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPH4</accession>
    <name>A0A7K2ZPH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_34455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001584">
        <property type="protein sequence ID" value="MYW34240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029879750" evidence="9">
        <location>
            <begin position="22"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW34240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="446" mass="47308" checksum="6643680B183CD12E" modified="2021-04-07" version="1">MIEVLLLLVALLLCVACGAFVAAEFSLTTVERGELERAVERGDRGASSALKAVRSLTFQLSGAQLGITVTNLVIGMLSEPSIAKLIRGPVEAAGLPPAAASTLALVIGTALSTVVLMVVGELVPKNWAISSPLSVARAVATPQRVFTAVFRPFISHLNNTANRIVRRFGLEPTEELASARSPQELVALARHSAKEGALEADTAELFVRTLNLAELTAENVMTPRVQVTALEVRATAEDVANATRATGLSRFPVYRGSLDTVVGVAHIKDVLAVPADERPRKRVSEMLREPLLVPETLTVDRLLDQLSGKLAMAVVIDEYGGTAGVVTLEDIVEEVVGEVRDEHDPHETPDLAAAGEDADGRTLWSADGAARTDQLSRIGLRVPDGPYETLAGLIAAELGRIPTVDDTVELAGWRIDVVDATGRRAARALLHAPPPGAEERTGEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPI9</accession>
    <name>A0A7K2ZPI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">GT040_34640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001587">
        <property type="protein sequence ID" value="MYW34276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="563"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="749"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1098" mass="120672" checksum="BBCCD28850CFB714" modified="2021-04-07" version="1">TVAEFPSWETLPHERLSPRSDTVGRRLAVLRRLAHPREDDPETGPVSVVVAPVRSVLQPQVKGLGELEPVSLASGQSADLGEVVDALAAAAYARVELVEKRGEFAVRGGILDVFPPTEEHPLRVEFWGDDVEEIRYFKIADQRSLEVAAHGLWAPPCRELLLTDEVRERAAALAEAHPELGELLGKIAEGIAVEGMESLAPVLVDDMELLLDVLPQGSMALVCDPERVRTRASDLVATSQEFLQASWAATAGGGEAPIDVGAASLRSIADVRDRARELGMMWWSTSPFAADDADHDEDTLKLSMHAPEAYRGDTARALADTKGWLADGWRTVYVTEGQGLATRTVEVLGGEGIAARFVPDLTEIAPSVVHVSCGAIDQGFVDPALKLAVLTETDLTGQRTATKDLGRMPARRRKTIDPLTLEAGDYIVHEQHGVGRYVEMVQRTVQGATREYLLVEYAPAKRGQPGDRLYIPTDQLEQVTKYVGGEAPTLHRLGGADWTKTKQRAKKAVKEIAADLIKLYSARMAAPGHSFAPDTPWQRELEDAFPYAETPDQLSTIAEVKEDMEKTVPMDRLICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLVQQHFGTFTERYSQFPVNVRALSRFQSETESKATLAGLKDGAVDLVIGTHRLFSSETRFKDLGLVIVDEEQRFGVEHKEQLKKLRANVDVLTMSATPIPRTLEMAVTGIREMSTITTPPEERHPVLTFVGPYEEKQIGAAIRRELLREGQVFYIHNRVESIDRAAARLREIVPEARIATAHGQMSEQALEQVVVDFWEKKFDVLVSTTIVESGIDISNANTLIVERGDNFGLSQLHQLRGRVGRGRDRGYAYFLYPPEKPLTETAHERLATIAQHTEMGAGMYVAMKDLEIRGAGNLLGGEQSGHIAGVGFDLYIRMVGEAVADYRAQMDGSVEEEPPLEVKIELPVDAHVPHDYAPGERLRLQAYRAIAQATSEDDIRAVREELTDRYGPLPEPVENLLLVAGLRMLARACGVGEIVLQGSNIRFAPVELRESQELRLKRLHPKTVIKSTAHQILVPRPTTGKIGGKPVVGRELLSWTGEFLTTILGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPT2</accession>
    <name>A0A7K2ZPT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoglycoside 2'-N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001597">
        <property type="protein sequence ID" value="MYW34345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="51" mass="5213" checksum="C228E2EBDBCA4AB5" modified="2021-04-07" version="1">VWPGGLAALGPHGTVALPAEEGSTYVRPAAGHVLPAAGHPLVFDWRDGDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ17</accession>
    <name>A0A7K2ZQ17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001606">
        <property type="protein sequence ID" value="MYW34378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="31092" checksum="87D669F2A81794A8" modified="2021-04-07" version="1">MVNIKELNPASSPQAAFGARIRRFREERGWTQDALAPRIGYSSQHISAVETVRKPPSLRFSRKSDHAFGTTGTADSFEREYMELRNGSLLEGFPEYVGYEGRAVEIRLFDVGLIPGLLQTPDYARAVAYGHVERGSITYEQADERVAFLEQRQAALVRSQPPMMFVVMDESCLHQAVGGAEVMNAQLRRLEEMSARPNWIIQVAPFSLGARRAFYLPVNLLTMADRSIVAYAESQSQGYVERETSLVAPMFTAYHQLQGEALSKAASAAKISKLRKGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQA5</accession>
    <name>A0A7K2ZQA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_35555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001624">
        <property type="protein sequence ID" value="MYW34449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="34080" checksum="14E4F701DC3657CE" modified="2021-04-07" version="1">MTDEMVKGLGERIPASLPNALRDHGLLVNTATGLYGWGAELETVYSGLANALSAEVAHKEPTELHFPPILPRAVFEKSEYVASFPQLFGAVHAFRGDEFAHEGLEKAVTKGEDWGGHTQLTDFVLAPAVCYSVYPLFGGSVLDESRTVDASGFCFRHEPSTEPGRLVSFRLREFVRVGSPAEASTWFDDWHARASAFVRRLGLEAKVEAASDPFFGTTGQIMADNQREEGMKAEVVAPIGGHPVAVASINYHHDHFGRIFDIRSADGEPAHSACVGFGLERIALALVAAHGPRLAEWPDDVRELLWSGRTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQE3</accession>
    <name>A0A7K2ZQE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001641">
        <property type="protein sequence ID" value="MYW34562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="44" mass="4679" checksum="3D61704CE954DD97" modified="2021-04-07" version="1" fragment="single">MPTRTTAAPQSQEQRTRRADRRFGVRLLGAVAAAAAAAIPFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQF6</accession>
    <name>A0A7K2ZQF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001641">
        <property type="protein sequence ID" value="MYW34573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="83"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="383" mass="40058" checksum="C6BCE4DDA756B854" modified="2021-04-07" version="1">MRSERAVAVFGAYGHTGRFVVAELRARGLRPVLVGRDPDKLKALAYGTETHGTGAWGTEGRAAGAYGAGGRAAGAYGTEDRAAAAYGTAPDIRAASADDPASVDRALTGAAAVINCAGPFATTAAPVIEAALRAGIPYLDVAAEIEANLDTFAHYAERARESQALIVPAMAFFGGFGDLLATAAMGDWTAADEVHIAYGLSSWHPTAGTRTAGAVSRERRGAGRRIRYTEGRLEHCDDAPPTLEWPFPEPLGPRTVIGEFTMADVVTVPSHLTVPEVRTYMTAEAARDLSSPDTPAPAAVDERGRSDQTFLVDVVVRSGGAERRAVARGQDIYAVTAPLVVEAAERVLTGRTRAVGVASAGRMFDAPGFLRALSPHIGVELFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQH7</accession>
    <name>A0A7K2ZQH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001646">
        <property type="protein sequence ID" value="MYW34593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="20211" checksum="1B86B1A325F32D51" modified="2021-04-07" version="1" fragment="single">MSFAPPSVPLSSPFDWIDDEARRRAAAGLVRALRPRSPQAGPLDLASNDYLGLTRHPEVTAAAAAAAHRWGAGATGSRLVTGTTALHTELERELADFCGFEAALVLSSGYAANLAALTALTGRGSLIVSDAGNHASIVDGCRLSRAETSVVPHADPDAFAKALQAHEGRALAVTDSVFSVDGDAAPLSALAEVCRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQP3</accession>
    <name>A0A7K2ZQP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metXA</name>
        <name evidence="6" type="ORF">GT040_36595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001674">
        <property type="protein sequence ID" value="MYW34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2 3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="399" mass="41835" checksum="8CA1A327EC08105E" modified="2021-04-07" version="1">MNRSAAPAALPLPPASGGRREGDPPGRRRWVTIEDPLPLESGVRLPGVRLAYETWGQRAADSSNAVLVLHALTGDSHATGPAGPGHPTPGWWDALVGPGRALDTDRWFVVAPNVLGGCQGSTGPSSPGPDGLPWGSRFPYLTVRDQVAAEAALADALGIGRWAAVVGGSMGGMRALEWAVSRPERTGSLLVLAAPAAASAEQIAWGSVQIGAIRSDPAWRGGDYHDAPPGGGPHRGLGQARRIAHITYRSEPELGSRFGGAPQPGEEPGRGGRYQVESYLDHHAAKLVHRFDAGSYVALTEAMNGHDIGRGRGGTPRALRRAEMPALVVGVDSDRLYPPPQQEELAALLPGADGLRIVTSPYGHDGFLIETGQVGSFVRELLPPPSPLTPSPLLHEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQQ7</accession>
    <name>A0A7K2ZQQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001676">
        <property type="protein sequence ID" value="MYW34663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9651" checksum="18F53CAC9025A00A" modified="2021-04-07" version="1" fragment="single">MDEELRSLLDRLRDEAAGSAAYDLLVATDDNEVLARVLVEPGRPLWAREIAAFRLGRAGDRRAFEALVLLLNHRDPERCVSAAHALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR09</accession>
    <name>A0A7K2ZR09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ORF">GT040_36995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="26537" checksum="4CE7581526D5FFA7" modified="2021-04-07" version="1">MTSTPPPPDRPRPPRTAAVIPAAGRGIRLGPGAPKALRALGGTPMLIHAVRAMAASRAVSLVVVVAPPDGAPEVKHLLDEHALPERTDYLVVPGGDTRQESVGLGLDALPEDIAVVLVHDAARPLVPVDTVDAVVEAVRNGAAAVVPALPLTDTVKEVEPAEVAGEPEPVLSTPVRARLRAVQTPQGFDRETLVRAHAEVALDGEGATDDAGMVERLGTPVVAVPGHEEAFKVTRPLDLVLAEAVLARRRAHDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRD0</accession>
    <name>A0A7K2ZRD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polynucleotide kinase-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_37920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001723">
        <property type="protein sequence ID" value="MYW34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07423">
        <property type="entry name" value="MPP_Prp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041780">
        <property type="entry name" value="MPP_PrpE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024028">
        <property type="entry name" value="PNKP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032390">
        <property type="entry name" value="PNKP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032380">
        <property type="entry name" value="PNKP_ligase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16536">
        <property type="entry name" value="PNKP-ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16542">
        <property type="entry name" value="PNKP_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04075">
        <property type="entry name" value="bacter_Pnkp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="207"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP_ligase" evidence="5">
        <location>
            <begin position="484"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP-ligase_C" evidence="4">
        <location>
            <begin position="808"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="867" mass="95329" checksum="1594281AE180B857" modified="2021-04-07" version="1">MTNDDSTSTTTDDTDTTTDDTGTAARTLPVTDLSLVVLIGASGSGKSTFARKHFKPTEIVSSDFCRGLVADDENDQSASRDAFDVLHYVAGKRLAAGRLTVVDATSVQSESRKQLVRLAREHDVLPVAIVLDLPEEVCAARNAARPDRASMPRHVIQRHRRELRRSLRGLEREGFRKVHILRTEEEAENARVVLERRYNDLRHLTGPFDIIGDIHGCRSELDTLLGTLGYVDGAHPEGRTAVFVGDLVDRGPDSPGVLRRVMSMVASGNALCVPGNHENKLGRYLAGRKVQQTHGLAETVEQLEREDAEHPEFRQQVREFIDGLVSHYVLDGGNLVVCHAGLPEKYHGRTSGRVRSHALYGDTTGETDEFGLPVRYPWAEDYRGRAAVVYGHTPVPTTSWINNTICLDTGVVFGGKMTALRWPERELVDVPAEKVWYEPTRPLATEAPGGREGRPLDLADVQGRRVVETRHLGRVAVREENAAAALEVMSRFAVDPRLLAYLPPTMAPTATSREDGFLEHPAEAFAQYRADGVERVVCEEKHMGSRAVALVCKDAEAATARFGTDGPSGALHTRTGRPFLDDRALTEVILGRLRTAVTAAGLWEEWDTDWVLLDAELMPWSLKAGGLLRSQYAAVGAASGAVFPSALAALETAAARGVDVGDLSVRQQGRAADAAAFTEAYRRYCWSTEGLDGVRLAPFQILAVQGRSLAAVPHDEQLAWLDRLVEHDPTGLLQVTRRLVVDPADEASVRAGTDWWLEMTGRGGEGMVVKPLGALVRDAKGRLVQPGIKVRGREYLRIIYGPEYTRPENLERLRSRFLGHKRSLALREYALGLEALDRLADGEPLWRVHEAVFAVLALESEPVDPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRL5</accession>
    <name>A0A7K2ZRL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Urease subunit gamma</fullName>
            <ecNumber evidence="4 5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureA</name>
        <name evidence="6" type="ORF">GT040_38385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the urease gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4 5"/>
    <dbReference type="EMBL" id="WWKE01001738">
        <property type="protein sequence ID" value="MYW34995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018516067.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001738.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="100" mass="11091" checksum="4FC808ABC66238B7" modified="2021-04-07" version="1">MQLTPHEQERLLIHVAADVAEKRRARGLKLNHPESVALITAHLLEGARDGRTVAELMASGRKLLTRDEVMEGIPEMLHDVQVEATFPDGTKLVTVHDPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSD9</accession>
    <name>A0A7K2ZSD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation:dicarboxylase symporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_39800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW35255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="469" mass="49294" checksum="55ACD96D490C7066" modified="2021-04-07" version="1">MSANSASAAPEAEQPSAAPEAEQPSTGSGPGPRIPKVPFWAQIVAGLVLGVLLGWLARSQDVSWLVTTLDKIGSIFVQLLKLAVAPLVFFAILVSITNLRKVNNAARLATRTLLWFMITSLIAVAIGLTIGLITNPGSGTGLTPKDGKLPERTGSWIDFLTGIIPNNVIEPFTELNVLQIVFMAAVAGIAALKLGEKAQPILTLSQSILELLQKALWWVIRLAPIGTVGLIGYAIAGYGWDLIGKYATFTADVYIGCLLVMFGVYPLLLATVAKVSPIQFFKGAWPAIQLAFVSRSSVGTMPVTQRVTERLGVPKEYTSFAVPFGATTKMDGCAAIYPALAAIFIAQIFDVQLGIGDYVLIAFVSVIGSAATAGLTGATVMLTLTLSTLGLPLEGVGLLMAIDPILDMIRTATNVAGQALVPVIVAAREKILDHDKYNSASASPIDAFDDAGRDEDRAPAPKDAVPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSE7</accession>
    <name>A0A7K2ZSE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family 2 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001802">
        <property type="protein sequence ID" value="MYW35227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="24860" checksum="467924A8E162ADAE" modified="2021-04-07" version="1" fragment="single">QALDEVTGLLGTLLRPGRILAARRDRGKGVVDAAELRALFPPPGATVRATVEQVAGNFGNKGEAESSGSRHGAVESGPGGDDADFLEVDQFARLKRIGRKPGPVLFALLLVVSLIACRNLLTGGSLAGGALLPAPAEAGELWGRYADAWHTISTGSTETAPPYLALLAALSALFLGSTGFAVAAILVCSVPLAGLTAYFASRPLLPSRLLRAWASVAYAFLPAATGALATGRLGTAVLLVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSR4</accession>
    <name>A0A7K2ZSR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001839">
        <property type="protein sequence ID" value="MYW35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029557473" evidence="2">
        <location>
            <begin position="36"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="233" mass="24198" checksum="E06E9F87B40413D1" modified="2021-04-07" version="1">MSFPTTGITTTTAATTSTATARLRLAAFVAVPVLALSVACVGGDDTAGTKSHDAIADVPAATDTPTTATTATTSGSTSATPSTQPDGKSAFYDAQMTFVRCMRAKGGYKDYPDPKLSGHLDWSKVNEIGSQPGRNQGVKAGMNNVCVDELQAVMAVEPERDQQKSYESMLAHAQCMRDNGVSRFTNPVMSGGNAMPGGDPNPASPVIDTDSPAYKQAREACAPKLLDGLDGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZST3</accession>
    <name>A0A7K2ZST3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001866">
        <property type="protein sequence ID" value="MYW35460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="10289" checksum="F41C9370ACA10E82" modified="2021-04-07" version="1" fragment="single">GAAGGGRSAVAVTALVAAVGGAVSVGLLSLAAEAATYAVFGALVVLFAGAALRTRAVVKQAVFAVAAVVWGMVLTGCAARSLELAPHEAAPLLLVVPAVTVLLGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSU0</accession>
    <name>A0A7K2ZSU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001861">
        <property type="protein sequence ID" value="MYW35454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="13416" checksum="8047F22C997253D4" modified="2021-04-07" version="1" fragment="single">MSPDQNPHPLTDHNGRTSGGETPMPLVDDVALHRPALPTPPPLFRPKEEDRLVGENPLVGKDPLVGEGSLSVEDRLPGEASPEGPDDLAALAQGSDPASAQDSDSAPAQRSALDPNPDSGSAPDPAPVSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Z1</accession>
    <name>A0A7K2Z5Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GatB/YqeY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000003">
        <property type="protein sequence ID" value="MYW27732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514200.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000003.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16331" checksum="99FCA43F95DAF473" modified="2021-04-07" version="1">MTTLKSKLKEDLHTAMKARDELTSSTLRLTLTAITKEEVSGKSARELSDDEVQKVIAKEAKKRREAAEAFAQGGRTEQAEREKAEGELLDGYLPKQLSDDELNAIVASAVEEAKAAGAEGPRAMGAVMKIVNPKVAGLAEGGRVAAAVKKLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Z2</accession>
    <name>A0A7K2Z5Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M24 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_00350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000009">
        <property type="protein sequence ID" value="MYW27760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="4">
        <location>
            <begin position="39"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="481" mass="51542" checksum="021B254820BC430A" modified="2021-04-07" version="1">MDRRDGSAGTGDRATGRPAAPEGLFGHGWAATDLALRPVPGAAWAAKRRAAVSARFPGERVVVPSGGLKVRSNDFDYAFRPHSAFVHLTAEQGTGAVPDSVLVFEPTGGGHEVTLFVRPRSPRDPGAGSTELHRDPRHGEFWVGRRRTLAETADALGIGTDHRDRVEAALATRVPTRVVRGQDPLVDSLVPPSADADEELLAFLSELRLVKDAWEVEQLDSAVRHTVAGFHDVAGELSHALRARRGERWIEGTFNRRARLEGHGLGFETIAAAGAHACALHWTRNDGPVRDGDLLLLDAGVEADSFYTGDVTRTLPVGGRFSDVQRRVYDLVFAAQSAGIAALRPGAPYGAFHDAATRVIAEGLDAWGLRPGGRHLPHGPALYRRYTVCGTGHMLGLDCHDCAAARDETYAGGTLEAGHVLTVEPGLYFQPDDLTVPEELRGIGVRIEDDFVITADGARCLSSGLPRDADGIEAWMSATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z642</accession>
    <name>A0A7K2Z642_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkene reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000018">
        <property type="protein sequence ID" value="MYW27809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="356" mass="37626" checksum="E66E77FFFA3617B3" modified="2021-04-07" version="1">MTTAFDPIDLSGTPLANRIVMAPMTRSRAGEGGTATELTAAYYAQRASAGLVITEGIQPSVVGQGYPFTPGLHSAEQVASWRTVTDAVHAEGGRIFAQIMHAGRIGHPVLLPDGLVPVGPSPVRAEGQVYTHEGPKDFVEPHELTDAEIRQTIADFVSASRNAIEAGFDGVELHGANGYLIHQFLAPNTNLRTDAWGGSETGRTRFAVEVVKAVAAEIGAARTALRISPSNVYNDIDEPAPEAVYTALVQEIEPLGLAYLHILEGAPIRELTLTLRKVFTGTVLINVHSDGPTGPDAHTVIDDGIADLISYGVLFLANPDLPARLKAGGPFNTPDPSSFFGGDAKGYTDYPALDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z650</accession>
    <name>A0A7K2Z650_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000017">
        <property type="protein sequence ID" value="MYW27806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8491" checksum="D90F62BDB3941774" modified="2021-04-07" version="1">MRGSSGGESPDLGADRPPGRDVTDESLVREYFASVERETTALPPAARQDLLADLGEHIEVARAERPGDVRAIPHEGATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z693</accession>
    <name>A0A7K2Z693_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF192 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000027">
        <property type="protein sequence ID" value="MYW27842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="14406" checksum="B2E3414F9D6AFD24" modified="2021-04-07" version="1">MRTWRDGDGTLTVGGDAGVREVPLRIAASYRSRTRGLLGRDGIDGALLLTPAGSVHTFRMRFAIDVAYLDRKFTVLAVRTMEPGRLGLPRLRSRHVVEAEAGAMERWGVRPGVRLELRALGTSWGKPAPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6J9</accession>
    <name>A0A7K2Z6J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Steroid 3-ketoacyl-CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_01440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000062">
        <property type="protein sequence ID" value="MYW27969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="266"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="392" mass="41547" checksum="B591E4473E04CB91" modified="2021-04-07" version="1">MAAEPVIVEAVRTPIGKRGGALANLHPAYLLGETYRELLGRTGIQADCVEQIVGGTVTHAGEQSMNPARNAWLAVGLPYETAATTVDCQCGSSQQAAHMVANMVAAGVIDVGISCGVEAMSRVPLGSGSKHGPGKPWPDEWNVDLPNQFEAAERIARKRGLTRERVDALGLLSQQRAAAAWAEERFKRETYAVQVPTTEEEQAGGQGMWRLVDRDEGLRDTSMEALAGLKAVMPSAVHTAGNSSQISDGAAAILWSSKRMARALKLKPRARIVAQALVGSDPHFHLDGPIDATRAVLGKAGMSLKDIDIVEINEAFASVVLSWAQEFEADLDGLEKVNVNGGAIALGHPVGATGARLITTALHELERRDKEFALITMCAGGALATGTIIQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6L6</accession>
    <name>A0A7K2Z6L6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="2" type="ORF">GT040_01530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000065">
        <property type="protein sequence ID" value="MYW27986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003959706.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000065.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6209976"/>
    <dbReference type="GeneID" id="63978673"/>
    <dbReference type="GeneID" id="66956124"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="14008" checksum="F972DD2AB7CA9256" modified="2021-04-07" version="1">MSERALRGTRLVVTSYETDRGIDLAPRQAVEYACQNGHRFEMPFSVEAEIPPEWECKACGAQALLVDGDGPEEKKGKPARTHWDMLMERRTREELEEVLAERLAVLRSGAMNIAVHPRDSRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6P7</accession>
    <name>A0A7K2Z6P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_01665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000070">
        <property type="protein sequence ID" value="MYW28011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="188" mass="19980" checksum="6904D80412D542C0" modified="2021-04-07" version="1">MSEPTDSPAPTTGRQPTPYVRDSHCSTCGAPYPALTAPGTWPRTCPRCGTTAYRNPLPVAVALLPVTGPASPGLVVITRTIQPQKGGTALPGGFVDHAEDWRHAVVRELREETGIEADEQDVRLADALSDTAGHLLLFGLLPPRPLAALPPSAPTHETSGYEILHAPRPLAFPLHTEAVNAWFAGRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6P8</accession>
    <name>A0A7K2Z6P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000065">
        <property type="protein sequence ID" value="MYW27983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="10584" checksum="8B5EC682A7A29911" modified="2021-04-07" version="1">TPEHRISVRAGFTAHTRGGWRAIGRDDAGLLVPGAPADYAVWRTAELLVQAPDDRVARWSTDPRSGTPGLPDLTPGAELPVCLRTVVSGHTVYMRPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Q6</accession>
    <name>A0A7K2Z6Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000068">
        <property type="protein sequence ID" value="MYW28002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="12066" checksum="AF5C7C996FE7C752" modified="2021-04-07" version="1">MRLGTIDRPQTHDPRNQAPMITPTQEPVGSATPDVTIIGANDSRQNRTREMQLIPEALARAHMHDRLREAQVDRQAVRLVAARRMQRRAERASLRARRALAMAVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Y7</accession>
    <name>A0A7K2Z6Y7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein GT040_02035</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000098">
        <property type="protein sequence ID" value="MYW28082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="12876" checksum="14DD4E1AC2EC0890" modified="2021-04-07" version="1">MNARGALGRYGEDLAARLLTDAGMTVIERNWRCRAGEVDIVARDGDALVFCEVKTRRPNGFEHPMAAVTPAKADRLRRLAGIWLERHGGPPAGGVRIDLIGVIVPRRGAPVTEHARGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7I5</accession>
    <name>A0A7K2Z7I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="103" mass="11164" checksum="12D741EDAEC8B83E" modified="2021-04-07" version="1">MVGRPWLAKPCRDAAVKIMQVAQPGAPVGNPAEDKHPGLYKASFDVVPVVKNVPFRGKPRQRFGAAVVNTAPHAWRVEKGDGRVPRYAVLQKAVDTVKVANRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7M5</accession>
    <name>A0A7K2Z7M5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">dxs</name>
        <name evidence="12" type="ORF">GT040_03475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="WWKE01000146">
        <property type="protein sequence ID" value="MYW28356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW28356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="637" mass="68144" checksum="68519F8992D44E64" modified="2021-04-07" version="1">MDLLTRIKGPRDLDRLSLGELEELADEIRTFLVDAVSKTGGHLGPNLGVVELTIALHRVFESPQDKVLWDTGHQAYVHKLLTGRQDFSRLKMKGGLSGYPSQAESEHDIIENSHASGVLGWADGLAKANEVLKKDDHVVAVIGDGALTGGMAWEALNNIAAAKDRPLVIVVNDNERSYAPTIGGLANHLATLRTTDGYERFLARGKDILERTPVVGRPLYETLHGAKKGLKDFIAPQGMFEDLGLKYVGPIDGHDIEALESALQRAKRFGGPVIVHCLTEKGRGYTPALQDEADRFHAVGKIHPDTGLPISTSGLDWTSVFGEEMVKLGHEREDIVAITAAMLQPVGLGKFEEAFPDRIYDVGIAEQHGAVSAAGLATGGLHPVFAVYATFLNRAFDQVLMDVALHKCGVTFVLDRAGITGTDGASHNGMWDMSILQCVPTLRIAAPRDADQVRAQLREAVAVDDAPTVVRFSKGAVGPAVQAVGKAGGMDILRKPKAARPDVLIVSVGALAPMCLEIADLLDAQGISSTVVDPRWVKPVDEALAPLAERHRVVVTVEDNSRAGGVGSAVAQALRDAGVDVPLRDFGIPPVFLDHASRAEVMTEIGLTAPDIARQVTGLVAKLDGRFESRAVEPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z840</accession>
    <name>A0A7K2Z840_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000198">
        <property type="protein sequence ID" value="MYW28527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="31857" checksum="94394AE9EA071AB9" modified="2021-04-07" version="1">MPRTRTHPWHGVMVATTLPFREDLSVDHDAFADHVRSLIDAGCDGVVPNGSLGEYQTLTDDERRRVVETAVEAAGDGARVMPGVSAYGSAEARRWAEQAADAGAGSVLLLPPNVYSADEAAVRAHYAEVARAGLPVVAYNNPYDTRVDLTPALLAQLHEAGDIVAVKEFSGDVRRAWEIAERAPGLDLLIGADDVLLELAVAGAVGWIAGFPNALPGSCTALYRAAVAGDLDTAVPLYRKLHPLLRWDSRTEFVQAIKASQDVVAEGSGGPCRPPRTPLAPQDESIVRALTGKLLVDGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8H4</accession>
    <name>A0A7K2Z8H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Keto-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.14</ecNumber>
            <ecNumber evidence="2">4.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="2"/>
    <dbReference type="EC" id="4.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000225">
        <property type="protein sequence ID" value="MYW28654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="11564" checksum="9CA37ECD62A66AA2" modified="2021-04-07" version="1">DALLEAMKGSGVPFLPGVSTTSEVVALLERGVSDMKFFPAEAAGGTAYLKALSAPLPQARFCPTGGISLASAPSYLALPNVACVGGSWMVPGDAIASKDWDRVARLAAEAAALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8J7</accession>
    <name>A0A7K2Z8J7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine N-alpha-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Histidine trimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">egtD</name>
        <name evidence="5" type="ORF">GT040_05055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:38471"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. EgtD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.44" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000223">
        <property type="protein sequence ID" value="MYW28651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030745">
        <property type="term" value="F:dimethylhistidine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02037">
        <property type="entry name" value="EgtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032888">
        <property type="entry name" value="EgtD_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="4">
        <location>
            <begin position="19"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-histidine binding" evidence="3">
        <location>
            <begin position="280"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="320" mass="34854" checksum="E2C6E5E40FA23924" modified="2021-04-07" version="1">MSPFLLTRTLPEDATDAALRADVLSGLTRHPKTLPPKWFYDARGSELFEDITRLPEYYPTRAEREILEERAEEIAAASGARTVIELGSGSSEKTRHLLEALDGLESYVPVDVSESALTGAAESLLAEHPGLSVHALIADFTGGLALPGTPGPRLVAFLGGTIGNLLPEERAGFLNSVRSLLTPGDALLLGTDLVKDEETLVAAYDDASGVTAAFNKNVLNVVNRELGADFPLEDFEHVAVWNPEQRWIEMRLRARRALTVKIRELDLVVPFEAGEELRTEVSAKFRQEDVREELAAAGLQLAQWWTDAAGRFALSLATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8W3</accession>
    <name>A0A7K2Z8W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000252">
        <property type="protein sequence ID" value="MYW28776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="17193" checksum="E5DB3E48DAA190EA" modified="2021-04-07" version="1">MPTNTLPHWTLRPGLPEDVEAVAELRAVVMRPDLERLGRYDEHRVRQRLRDAYVPAYTSVLETPDGFAGCVTLRPAGNCWWLENFLLSPALQGHGIGSAVLRGLLDRADAERMPVRLNVLQGSAARRLYERHGFALEREDPIDVFLVREPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8W9</accession>
    <name>A0A7K2Z8W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000253">
        <property type="protein sequence ID" value="MYW28789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="307" mass="32599" checksum="AC82A0CD3DC3F8A9" modified="2021-04-07" version="1">MTPAAASLRDLVRLRAEHPEAVAEAAARRKRRPLIRAEGIASDRARPPHPGRLMIIAADHPARGALAVGGRALAMANRFELLERLRLALSRPGVDGVLASADVLDDLLLLGALEDKVVMGSMNRGGLAGAAFELDDRFTGHRPDDLVRHGFDAGKLLLRIDHDDPGSLDTLHTAARTIDAMAAHRLPVFVEPFLCRRVDGRLRNDLGAAAVATSIAIASGLAGTSAYTWLKVPVTEHPDDMAQVMETSTLPAVLLGGEVGDDLDGAYGKWREALRLPTVRGLVVGRSLLYPVDGDVAGAVDTAVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAB4</accession>
    <name>A0A7K2ZAB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_08295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000382">
        <property type="protein sequence ID" value="MYW29278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="34045" checksum="2AF4C0F312F6B5AD" modified="2021-04-07" version="1" fragment="single">MTATTAASGGAVRNLTRGQWRLLLGGTALGLLGVVCTLAQPVLLADLIRAAGDHRPVAGVVVALVVLFLLDAVLSAAQGCLIGRAGENIVRDARVLLSGKVLRADRAHLDTLRQGDLHTRLVADTSLMKIALTQSLAQIVLNGLIVVGAVVMMAFTDIWLLLIAVGCLGFAGTGSVWLARALRRAALANREDIGDFGADLQRVLTALTTVKAANAEGREQHRLAESADRARVSGNRVTVLNALFTPALNVGLQASLAAVMGIGMARVVGGSISLADFSAFAMYLFYLVSPLVLVFLSIGTYLQGRAAVQRVDELDTLPQEDEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAC5</accession>
    <name>A0A7K2ZAC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TOMM leader peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000383">
        <property type="protein sequence ID" value="MYW29284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="133"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="529" mass="56972" checksum="25F0A4B039B23F96" modified="2021-04-07" version="1">AETLAGLIAARLDGGGPQTGAFPAVHLVDLQTLAVRHYPLVPDPECPVCSTPEPDTDAAATLTLKPAPKLRPGSFRVRDIGSYELPVEPYANPVCGSLGPSVVQDVSSTSTSATIGCFSMRSGPYLRETFWGGHADTFAESVRIGVLEGLERYAGMRSRAKRAQVHASLDGLRAVGRAAVDPRVVGLYSDAFHAANPRVLPFTSDREIPWVRGWSLRDGKTVLVPEVLTYYHAPGLENRFVQESSNGCASGGALEEAVYFGLMEVVERDAFLLSWYGRAALPEIDPRTSRRPATRQMVDRLEMYGYEARFFDTRISFPIPVVTGVAVRPDGGPGRMCFGAGAGLDPEAALAGALCEIATDAVNLQGRTERDEERLRAMAYDFDKVAALHDHPLAYGIPEMGDHADFLLGAPGSVRQPPLSLAELYGDGPGARPVLPVSDDLREDLQRCVDAVTGAGFDVVVVDQTMPEQRALGLTTVSVLVPGLLPIDFGWSRQRALHMPRLRTALREAGLRTADLTDADLNPAPHPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAC7</accession>
    <name>A0A7K2ZAC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LamG domain protein jellyroll fold domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_08580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000402">
        <property type="protein sequence ID" value="MYW29331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="813"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1203" mass="126831" checksum="455A5C9B4875C61A" modified="2021-04-07" version="1">MSLLVMPVPDARGATVTDEPPAVTEDQRALDQAEETGTRVEVEGQRSEYATVYANPDGVSFTLEQSVTPVRVAKAAGGWQKPDATLERRSDGTIGPKAAAVSISLSGGGDGALAKIEKAGLSLELEWPQELPVPRIDGASAVYDDVLPDVDLKVTATVASFQQVLIVKTPEAAGDPRLKKLTLGMETSGLDVRRGSAGNLAAVDGDGRTVFRAPPAQMWDSAGTAAAPRSAASKGRAGAEASQRTGVTGGRAEPAASGSVTEPGQGDNVERIDVQVTKNSLTVVPDAAMLEGTSESAFPLFIDPPVTWGESERTLLRSDGYESYEWNNGDDGQGKGVGKCGTWQGYYCGPGYVQRLYFEFSPANLKGKNVLSASFRVTEPWAFQCDPRVVDLVRTTNISSSTTWTTRPTHLDLMVDRNVSAGRGSACDPDQPDAPIFFEDSPSESNENLTPTVKSFAAGKFARLTLMLKAHDETDTSAWKRFKNDAVLVVKYVGLPALPKSTGLVAGTGLVCSTDSGDPSTIGDPEPLVTGKPMAASGGTSQANLRIRWRTEKLSGSTWSVAHTDVDGPTSGYVGSGATQNRRLPKLAEGVLYRLKALTMSYDEAGANRLNTGYTTPCYFKVDRSRPLPPVVTPASGSPYTLCGTVCLPGGGPGTKGRFTFAPAAGDTNVAYQYRRSDSVPWSGEIKGSTVGVDIVPQESGTYQLQVRAKDAVTWGAVQIVSFLVKEGSGPVGRWRFDEKSGPAIDSSTTVAANQENATLATGAVRDGLGRRGELRHGPDGQPLATPVTDTGLRLNGTSGYAATSAPVLETRSAYTVSAWVRMENKDTEGIVLSQDGAQFSPFLLWYENTYDSWCFGTKAQDAADGKAYHGVCGRRPAVVNAWTHLAGSYDPVTKTVVLYVNGRQQGSVVSDGGWAASGGFQIGRYKWANKYQFNFNGSIDEVAAWQRVLSPAEVATEARSLSAGTGQANVELVAHWDPFGASGTTLADKGTGYGRNLATAGGAVLDGRSLVLDGKDGAAATSGPVVDDSGSFTVTAAVELDQQALLTKNIGYVGQVAGQRTATGSSWGLWFKLTGKETRFDDDGNEYTAPVGLWHFGRVGANGAGDWVSSDEEAELGSPVRLTGVFDALDETGGSVVRLHVGLKQNDMDKTYTSAIGAGDFAVGKGYSTTAWGHHLPARVDDVRLWAGAMSDVDQIADVVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAV9</accession>
    <name>A0A7K2ZAV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000421">
        <property type="protein sequence ID" value="MYW29469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="25937" checksum="D279ADD1908ABBE1" modified="2021-04-07" version="1">MSATFHGKVALVTGAGSGIGRRSARAFAERGATVVVADLDGENAAHTVKLIEQEGGTASAVTVDVTDADSVRTAVDATVARHGGLHIAHNNAGVFAALGPAGDIDEKQWHTQLAVNLTGVMLSMKYEIQHMRENGGGVIVNAASNIGYHLRYPGTGAYAASKAAVSTLTRAAALDHIKDGIRINAVSPGASNTPMTFMPGESEADRAARLNGTIPLGRIAETDEIVASVLWLASDDSSFVVGHDLVTDGGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB01</accession>
    <name>A0A7K2ZB01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000444">
        <property type="protein sequence ID" value="MYW29519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="326" mass="35220" checksum="6C7B0FF2D79133F7" modified="2021-04-07" version="1" fragment="single">MDTQQNTALMRALTELPGPLPARGVIQITIPHTDRFTVVGNHLAQHPGLSTAAVGFAVRIQSLPQGTEVGVKALAARFPEGEKLIGAALRELEAHGYLRRARTRLTNGRIVTRTVFCNQPAALLRPRVTAARPQQPPAAPQTPPPAQEPPAPEPAAPQAPAPPDVQQQQAPEAPAPQDHAPFVALVPPPTAPRQPSPPLPQPRELTAELDRAATALLSDLRRHARQLVLSENDIRQLAPAVAAWLERDTHPDTIRHTLTNDLPQPLRHPAKLLKHRLTVLLPPPLPGADDLAAPARPRIAVTPFQTCDGCERAFRAPTPGHCRDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB46</accession>
    <name>A0A7K2ZB46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000457">
        <property type="protein sequence ID" value="MYW29587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="21945" checksum="76D815E531FA73AA" modified="2021-04-07" version="1">MSQSAQKARGWLVGIAVLCGIWLVQNGSGDQVIPPQPSSAQAFAAGPQLQPGSPVAEPLHPSDPVRIRIPSISVDAPMMRLGLGADGSLDVPPDTDRNLAGWYAGGVPPGAKGTAIVAGHVDNAEGPSVFYALGALTKGTRVEVVREDGRTAVFSIDAIEVYDNKDFPDQRVYGESPHASLRLITCGGGFSKETGYQGNVVAYAHLTDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBE0</accession>
    <name>A0A7K2ZBE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000483">
        <property type="protein sequence ID" value="MYW29680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="159"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="30746" checksum="763DCBDA107D9BBC" modified="2021-04-07" version="1">MKKAVVVGVDGSPESLAAADWAAREATLRSLPLRIVHAWLWQPLDVPLVQNRETEAQAARAVLREAEDQVAGRYPELSVSSRVLPETAVVALLAEAERSALLCLGTRGHGALLGFLLGSYGQQVIAGANGPVVSVRAYDGEYPIRENGEVVVGQQGTPDDSADVLGFAFEAASVRGVPLRAVRAWSLPPVYTWSASLALADASGGLEPFERKALQEALAPWREKYPEVQVTEHVEMGSAGQVLVEESAEAQLMVVGRRARRAPIGTRIGSAAHAVLHHARCPVAVVPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCV9</accession>
    <name>A0A7K2ZCV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000609">
        <property type="protein sequence ID" value="MYW30211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="314" mass="34466" checksum="EDB5C09F78FF6AD5" modified="2021-04-07" version="1">MASLAAMRADASALTGRHPAHVFRPLSETLNRWAAEGIDTTPFHAGLESAERRYAGYGLTTMLPLDRVLVGCASSRAGAFGGFHHPDQGYGHLQMMAVITMYGPMERPDPERPALALLDLLRAYAHDCLHYGSRRRYVEVAGMPVRTQYGINYRRVNGQSYSAADRTGSRHTRNLGIVMEGACDREARSITRKAAEQFGITEPSDTVGALAFRDVTGTLTDGDARRVGNVPERGEQARYAAALTGYETGINRRYAHFLTEFTPGEESECHRRILTAVITGDVTELGAWLDERHGPGTFTGLFRTPGYFEPVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDQ1</accession>
    <name>A0A7K2ZDQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000672">
        <property type="protein sequence ID" value="MYW30449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="34"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="19380" checksum="4331E4E0C3051A54" modified="2021-04-07" version="1">MTPRQPTTEPDARYSSALDPRPGAENVTATDWAEAERRLSGAEVFWITTVRTDGRLHVTPLMAAWYDGTLFSSTGPGGQKARDLAGNAHCALTTGHGSLAGGLDIVVEGAAEQVTDPARQDEAIAAFEAQYGDHITSPQGAFFGFGDSIREGRDLLFAVVPITAYGFGRDGQVFSHTRYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE37</accession>
    <name>A0A7K2ZE37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_15330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000720">
        <property type="protein sequence ID" value="MYW30614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23835" checksum="C5E373AB4D9C9B48" modified="2021-04-07" version="1">MRHGEVHNPDGVLYGRRAGFSLSELGRQMADRVAEHLEKRDITHVVASPLERAQETAAPIAKSHSLALATDERLIEAANVFEGKTFGVGDGALRKPENWKHLTNPFKPSWGEPYIEQVVRMMSALDAAKDAARGHEAVCVSHQLPIWIVRSFVERRRLWHDPRKRQCTLASLTSFTYQGDRIVSVGYSEPARDLVPAHLLAGAKPVKGKSKAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE57</accession>
    <name>A0A7K2ZE57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2191 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_15480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000724">
        <property type="protein sequence ID" value="MYW30643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032756544.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000724.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="8342" checksum="BA07BF3ED4FA939C" modified="2021-04-07" version="1">MTQIDIDDEALERAMALSKARTKKETVNLALRFYAEQQERAARISRHFERARNWGAVEDAERRHRAEKDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZER2</accession>
    <name>A0A7K2ZER2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoacid dehydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030563182.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000769.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="326" mass="35501" checksum="76E4E2468E9F726C" modified="2021-04-07" version="1">MAVEKMSIAKALNESLRLALDTDPKVLIMGEDVGKLGGVFRITDGLQKDFGEDRVIDTPLAESGIVGTAIGLALRGYRPIVEIQFDGFVFPAYDQIVTQLAKMHARALGKIKLPVVVRIPYGGGIGAVEHHSESPEALFAHVAGLKVVSPSNASDAYWMMQQAVQSDDPIIFFEPKRRYWDKGEVDTESIPGPLHKAVTVREGSDLTLVAYGPMVKVCLEAAAAAQEEGKSVEVLDLRSMSPIDFDAIQTSVEKTGRLVVVHEAPVFYGSGAEIAARITERSFYHLEAPVLRVGGYHVPYPPARLEDEYLPGLDRVLDAVDRSLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF76</accession>
    <name>A0A7K2ZF76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dapA</name>
        <name evidence="11" type="ORF">GT040_17420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="WWKE01000814">
        <property type="protein sequence ID" value="MYW31010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW31010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="293" mass="30320" checksum="059E55B1C4C2B4AE" modified="2021-04-07" version="1">MTATAPRPFGRALCAMITPFTATGALDLDAARAHAAHLVAGGCDGLVLSGTTGESPTTSDAEKSDLLRAVRAEVGDGVPLLSGVGSADTTHAVRLAREAEEAGADGLLVVPPYYSRPPQAAVETYFLRIAGATGVPLMLYDIPGRTGVRIEPETLLRLADHPRVVAVKDCAYDLLGSTKVIARTGLAYYSGCEELNLPLYALGGAGYVSTVANVAPRQMRAPLDAFDAGRTDEAARLNGLTVRLAELMMAGGLPGTVTAKALLDAGPVREPLQPAGREAVDGLRAAYEELLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFC8</accession>
    <name>A0A7K2ZFC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA</name>
        <name evidence="12" type="ORF">GT040_17690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="WWKE01000829">
        <property type="protein sequence ID" value="MYW31064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW31064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="341" mass="36495" checksum="9499F1B85F9E2EE7" modified="2021-04-07" version="1">MRIGILTAGGDCPGLNAVIRSVVHRAAVGHGDEVIGFEDGFKGLLDGHVRPLDLNAVSGILARGGTILGSARLERDRLREAAENCEELARRYGLDALIPIGGEGTLTAARMLSDAGMPVVGVPKTIDNDISATDRTFGFDTAVGVATEAIDRLKTTAESHQRVMVVEVMGRHAGWIALESGMAGGAHGICLPERPFEVDDLVKMVEERFARGKKFAVICVAEGAHPAEGSMPYAKGAIDQFGHERFQGIGNRLAVELETRLGKEARPVILGHVQRGGTPTAYDRVLATRFGWHAVEAVHRGDFGRMTALRGNDIAMVPLADAVTQLKTVPLDRMYEAESVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFS6</accession>
    <name>A0A7K2ZFS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000867">
        <property type="protein sequence ID" value="MYW31227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013230">
        <property type="entry name" value="Peptidase_M15A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08291">
        <property type="entry name" value="Peptidase_M15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_3" evidence="2">
        <location>
            <begin position="94"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="222" mass="22871" checksum="8B11014BAFF2D5DE" modified="2021-04-07" version="1">TASGDIGTADACYTWGGTLREGSSGEAVRQLQIRVAGYPGTGNQIAIDGAFGPATKAAVTRFQAAYGLAADGIAGPATFNKIYQLQKNDCTPVNFTYAELNRCNSDWSGGKVSAATARANALVTMWKLQAMRHAMGDRPITVNGGFRSVSCNSAVGGAANSRHMYGHAADLGAGSQGFCALAQAARNHGFTEILGPGYPGHNDHTHVAGGSGRFWSAPSCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFW9</accession>
    <name>A0A7K2ZFW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytidine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_18540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000866">
        <property type="protein sequence ID" value="MYW31218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="12741" checksum="4E1ABBE88CE99651" modified="2021-04-07" version="1">MREAARDAMSRAYAPYSGFPVGVAARVDDGRTITGCNVENASYGLSLCAECGLVSTLQATGGGRLTHFTCVDGTGSVLVPCGRCRQLLYEFGGPGLLLETPDGRRTLDEMLPQSFGPQHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG25</accession>
    <name>A0A7K2ZG25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type VII secretion protein EccE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eccE</name>
        <name evidence="4" type="ORF">GT040_19100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000891">
        <property type="protein sequence ID" value="MYW31321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03923">
        <property type="entry name" value="T7SS_EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="30711" checksum="289B6058F69E3657" modified="2021-04-07" version="1">MLGDGTFLTAAVRVEAGGEALRPAFGARSLPLSLLGDALQVDDIVLESAQLVQQVRAAPAPQLPQRSVARLSYAPLQDKTGAPALRMTWVAVKLDPELCREAIEARGGGLEGAQRALVRVADHVASRITGAGFRAVVLDQDELNSAVATSACANPLLSGRAGRPDAAPQRRTMETSRVWRCDDRWHTTYAVERWPELGRGATPLPQLVALLTSVPAYATTFSLTVRRGVRQGETSVSGHVRVTGGSDTELVGVRRTLEQAARHAKVGLARLDREQLPGVLATLPLGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGH6</accession>
    <name>A0A7K2ZGH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000913">
        <property type="protein sequence ID" value="MYW31418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="29054" checksum="EB55CE5F062825F3" modified="2021-04-07" version="1">MIPKVHLPESRTMITLEVLRRESLSPGFASVTLGGPAVRDLMIAGGDQAVRLFFPREGQTGLRMPTLSNEAWIAQLMLLPKSVRPWVRNLTVRRARPEQGEIDIEFALHGDAPLSSWVRRVEPGDPAGIFDIGTTYRLPEHAEGQLLVGDETALPAILSILDGATAGLPTEVHLEVASSADIRSVETPAGVRIHWYARDDAELRPGAPALAGVRDATLPSGRFTTWVAGESRLATSVRRYLVNERGVPKRDVTFVGYWRLGRSSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGL4</accession>
    <name>A0A7K2ZGL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1080 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000920">
        <property type="protein sequence ID" value="MYW31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="227"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="420"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="960" mass="103388" checksum="C2F022BC9DCD8424" modified="2021-04-07" version="1">RPEIYAMGFRNPFRFSVDQATGIAYVGDYGPDAGAADPKRGPSGKVEFARVTKAGNFGWPYCVGENEPYIDYDFATKTSGAAFDCANLTNESPHNTGLVDLPPAEAAWIPYDGGSLPEFGTGSESPMGGPVYRYDADLDSPVKFPEAYDGDFFAGEFGRRWIKRIEQDADGAVQSINDVPWSGTQIMDMAFGPDGALYVLDYGLAWFGGDENSALYRIENATGGRSPIAEASANKTSGTAPLKVKFSSAGTADGDGDPLTYAWDFGDGGTSTAANPTYTYKKNGTYVATLTAEDPSGRTGSASVHVTVGNTAPTVELVLPEDGQLFEFGDSVPFKVNVSDPEDGTIDCTKVEVKFTLGHDSHGHDITTEHGCEGTIKTAMEGGHDPNANIYGGISASYTDNGGGGQAKLTGRDQARLQPKHRQAEHFDDSFGVTTPSKSSAHGGKTVGDIHNDDWISFKTYVLGGTTKLTARISSAGSGGFLEVRTGSPTGKILGSGPVPVTGSWDTFQDIDIPLRGAPKKKTDLFLVFKGGDGALFDIDDFELSNTPVDKTAKRVLVFSKTAGFRHDSIPAGIAALKEIGKDTNITVDSTESAAQFTTSNLARYDAVAFLSTTGDVLNADQQKAFENYVATGGGYVGIHAAADTEYDWEFYGGLVGAYFDSHPQIQPATVRIEDHDHPATAHLDEEWERTDEWYNYRTNPRDKAKVLATLDETTYTGGNMKGDHPISWCQTYQGGRSFYTGLGHTKESYAETAFRQHLSGGLRYATGQVKADCKPNKDYRPIFNGKTLEGWKQAGPGKFSISDGALHSEGGMGLLTYQAKELKAYSLKLDWKMAGDDNSGVFVGFPESDDPWSAVNNGYEIQIDATDAADRTTGAVYGFKSANIKARDRVLRPPGQWNSYEIKVQGERLQLFLNGAKINDFTNTDPARSLKDGYIGLQNHGADDQVSFRNIQLKELPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGS0</accession>
    <name>A0A7K2ZGS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000956">
        <property type="protein sequence ID" value="MYW31547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015611637.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000956.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14247" checksum="774D255191790E20" modified="2021-04-07" version="1">MTPPPASPDPYGALHHASYDEGGDQPLVRPYAMTGGRTRPRYQLAIEALVSTTADPAHLGTLLPEHQRICHLCREVKSVAEVSALLSMPLGVARILVADLAEAGMVAIHQPGNGEAGGAPDVTLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGY9</accession>
    <name>A0A7K2ZGY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GT040_20625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000972">
        <property type="protein sequence ID" value="MYW31616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029726973" description="Cytochrome bc1 complex Rieske iron-sulfur subunit" evidence="12">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="59"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW31616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="14702" checksum="D4FA41086AFDB5FF" modified="2021-04-07" version="1">MNANARRRTVLTAGAAGAAALVTGCGSSGDESGGGDASGTPTGTASDAASPGASPGGGEELAATGDIPVGGGTIFKEQKVVVTQPEEGEFKAFSAVCTHARCLVSTVSDGTINCPCHGSKFSITDAAVEAGPATRPLPAEQITVEGGAIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH11</accession>
    <name>A0A7K2ZH11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000974">
        <property type="protein sequence ID" value="MYW31632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="13830" checksum="3BF09760C136A2DC" modified="2021-04-07" version="1">AEAAGVGLALETHDTFLTGAEVAAVLEAVGSPHAGAVWDAVNPWRAGESPERTAALLGPWLRHVQLKDVASPTDLRPVPPGHGVLPLPSVLAQLGHLGYGGWISLEWERAWYPDAAPLADALPAFHRVLDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH34</accession>
    <name>A0A7K2ZH34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_20870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000981">
        <property type="protein sequence ID" value="MYW31664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029536957" evidence="2">
        <location>
            <begin position="27"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="96"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="574" mass="61716" checksum="DA4A9487165A15C0" modified="2021-04-07" version="1">MRQPSVISRRVAAATVTLVLATGAAACGPEDSKGGDSGSGAGGTPQKGGTLTVLNRNTQQDFDPARLYTSGGGNIPSLVFRTLTTRNREDGADGAQVVPDLATDLGKPNEDATVWTYTLKEGLKYEDGTAITSADIKYGIERSFAPELSGGAPYLRDWLIGGADYQGPYRDKKGLDSIEVPDDRTIVFRLNKPEGEFPFLATQTQTTPVPKAKDTGTKYEEHPVSSGPYKVVTNENDGERLVLERNPHWSATTDEERKAYPDRIDVRSGLDAAVINQRLSASQGPDAAAVTTDTNLGPAELAKVSSDKKLAARVGTGHFGYTNYIAFNPKVKPFDNPKVRQAISYAVDRSSVINAAGGSSLAEPATTFLPERDSFGHAPYDHFPAGKTGDAAKAKELLKEAGYDKGLTITLTHSNAKDFETSPEIATALQAALKKAGITVKLQGLEDNDYSDTIHDAKKEPGFFLAHWGADWPSGGPFLAPIFDGRQIVENGANYNTSFLNDPEVNKEIDEINKLTDLKAAAARWGALDKKIGEKALTVPLFHPVYKRLYGQDVKNIVISDWTGVLDVSQVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH40</accession>
    <name>A0A7K2ZH40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_20880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000982">
        <property type="protein sequence ID" value="MYW31666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="10455" checksum="FEFBF6BB8A8C39EA" modified="2021-04-07" version="1">MKFVWDQSSRDDYVWWQNQDRKILKRINTLLQDIARNGNEGMGKPDPLKHGFQGYWSRRITDEHRLIYKVVDDEVRIAACRYHYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH47</accession>
    <name>A0A7K2ZH47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000968">
        <property type="protein sequence ID" value="MYW31589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="31801" checksum="365A5447C04F5722" modified="2021-04-07" version="1">MSHVVRAALVQATWTGDTESMIAKHEDHAREAARQGAKIIGFQEVFNAPYFCQVQDPEHYRWAEPVPDGPTVRRMQGLARETGMVIVVPVFEVEQSGFYYNTAAVIDADGSYLGKYRKHHIPQVKGFWEKYYFKPGNAGWPVFDTAVGKVGVYICYDRHFPEGWRQLGLNGAQLVYNPSATSRGLSGYLWQLEQPASAVANEYFVAAINRVGQEEYGDNDFYGTSYFVDPRGQFVGEVASDKEEELVVRDLDFGLIDEVRQQWAFYRDRRPDAYDGLVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH51</accession>
    <name>A0A7K2ZH51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000984">
        <property type="protein sequence ID" value="MYW31681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="49"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="27696" checksum="269FF03BC27E5AB3" modified="2021-04-07" version="1">MTETGTSTDWQSWQESWDRQQEWYMPDREERFRVMLDMVEAVVGPAPRVLDLACGTGSITDRLLKRFPDATSTGVDLDPALLAIARGTFEGDDRVTFHAADLKDPDWTTGLPHTSYDAVLTATALHWLHSEPLAVLYGQLGGLVRDGGVFMNADRTIDPETPRINAAERAHRHAGMDRAKAAGVLDWADWWALAAADPVLAGPTAERFAIYGEHADGDMPSAAWHARTLLASGFAEARTVWASPSDSLVLAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHC8</accession>
    <name>A0A7K2ZHC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="16541" checksum="08BD750EDEAAB283" modified="2021-04-07" version="1">MSDLEIRPVAETDLDAVVAMLADDPLGAQRESPDDLTPYRAALRRLADDPNQHVVVAVREGRVVGTLQLTVVPGLSRRGATRSIIEGVRIHADERGSGLGTQLIQWAVDESRRQDCRLVQLTSDATREDAHRFYERLGFTASHVGFKLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHV7</accession>
    <name>A0A7K2ZHV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_22280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001060">
        <property type="protein sequence ID" value="MYW31927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="325" mass="35758" checksum="41435BF6BC436AD4" modified="2021-04-07" version="1">MLQFLIRRLTGAVVIMFLIGAFTFFLFYTIPQDFAQLSCGKNCSPENIAVIRENLGLDKPITAQFWDFMSGIIVGRDFATGHCSAPCLGQSFSTGDFVWDSIMDRFPLTLSLTVGGLVIFLILGLGSGLLAAWKRGTAIDKVVSGASMLLSSFQIYFLGPIVLGIFVFSTGWMENPKYIPFTENPVGWAVGLLLPWAVMATIFTAQYTRMSRSTMIEQLQEEHVRTARAKGMPARYVFFRYAWRGSLAPIVTILGMDLSGLLAGGVVTEFTFDLAGIGRLAVESSLTKDLPLTMGVMLFGAFFILLLNIVVDLAYAYIDPRVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI53</accession>
    <name>A0A7K2ZI53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001065">
        <property type="protein sequence ID" value="MYW32008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="20243" checksum="EB697CE1AEC4699F" modified="2021-04-07" version="1">MHRALIVVDVQNDFCEGGSLAVAGGADVAAAITDLIGEAQPGYRHVVATRDHHVDPGDHFSETPDFVDSWPVHCVAGTEGVGFHPNFAPAVASGAIDTVFDKGAYSAAYSGFEGADENGTGLAEWLRERSVTEVDVVGIATDHCVRATALDAAREGFVTHVLLDLTAGVSSATTEKALDELRTAGVKLSGEPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI57</accession>
    <name>A0A7K2ZI57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001071">
        <property type="protein sequence ID" value="MYW32042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="11410" checksum="F9B3CFAD69899867" modified="2021-04-07" version="1">MLAVLSGQRPVHWMLGHTIGDAYDQLAELAPSTPLGATRGHRPVLRHCHGAQPATGVVEAFASIAAGDRVRAMAFRLEQGPDQRWRCAAVELGGERLVPAGNAGPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI88</accession>
    <name>A0A7K2ZI88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001076">
        <property type="protein sequence ID" value="MYW32072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="17142" checksum="B2FA8CF236ADE909" modified="2021-04-07" version="1">AEAERALGGGRAEELFAETYRKMVLSPGAAAAYRAFLETAADPAARPVLFHCTAGKDRTGWAAAVLLMILGASRETVRQDFLAVNPAVRAAFAPYVQKFLDGGGDPAVAAAIVEVRPRYLETALDAMDERWGGLDGYVRTGLRIPEPVLERLREGLVIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIA5</accession>
    <name>A0A7K2ZIA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001083">
        <property type="protein sequence ID" value="MYW32092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="17813" checksum="A65AE32829F3F627" modified="2021-04-07" version="1" fragment="single">MEYRRAAIPALVGGLLLTALLWWAGASTQALRLPGTIDVLGGLTAAQLEHWLTPWSYDPPSSVRIGAETFGVGEDGAAIDNSRYLSLYTTGMQIRFAAVLLFFVPGALLLVRRLPPVNGRVPATLLAVWAWGLVAGALAVAVSAPWLIAANGRGSYRFLPQLAGMASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZID3</accession>
    <name>A0A7K2ZID3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001105">
        <property type="protein sequence ID" value="MYW32123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11058" checksum="7FAB398F63A52322" modified="2021-04-07" version="1">QDRSGFVVNALLIPYLLSAIRMFESGIASREDIDNGMEMGCAHPMGPLKLADLIGLDTVASVADSMYAEYKEPLYAAPPLLQRMVDAGRLGRKTGSGFYPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIE0</accession>
    <name>A0A7K2ZIE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001090">
        <property type="protein sequence ID" value="MYW32107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029464440" evidence="1">
        <location>
            <begin position="32"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="204" mass="21252" checksum="F6E151D2774EEE4B" modified="2021-04-07" version="1">MRTTRTFRAALLTAAVAGLAATALPMAPAAAAPAVPKFLSAGQWPASLTPWTAGPVRKGLPEEGSVCTAGTIPATGTRHRDFRTELDTGARQTITVAPTAAKAKALAAELRTALATCLDRLKEQEPGLEGVSRYHGRVSVEEGAHVYSIDTSYPEVGSTDIGLHSVGRDGRTVTVLEWGQLGDLDGAPLKGFRKTTGTAVAKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIL0</accession>
    <name>A0A7K2ZIL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6954" checksum="B29120799A550D73" modified="2021-04-07" version="1">MTHRPDEEEEDTVDTDFEFDFTHLGTEPVALLPKAGPGHPPTILLRRDELLPTRWRQLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIT1</accession>
    <name>A0A7K2ZIT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_24010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001119">
        <property type="protein sequence ID" value="MYW32251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="27984" checksum="3EE92D41493756F7" modified="2021-04-07" version="1">MTDPALTELLDLALEAARRAGALLRDGRPADLGVAATKSSPIDVVTEMDIAAEKLITGYLSDFRPDDGFLGEEGASSPGSTGIRWVIDPLDGTVNYLYSLPTWAVSIAAERDGERVVGVVEAPMRRETYQAVLGGGAYANGNALRCRPAPPLDQALVSTGFNYVSTVRAHQADVAQQLIPRLRDIRRSGSAAVDLCDVAAGRLDGFYERGLHPWDLAAGDLIAREAGALTGGRPGLPADGDLAVAAVPGVFEPLQAALEELGAWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ68</accession>
    <name>A0A7K2ZJ68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ORF">GT040_24670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001154">
        <property type="protein sequence ID" value="MYW32374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="225"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="55"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="76"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW32374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="35135" checksum="B5F22100D1C41851" modified="2021-04-07" version="1">MSARPNQESAAPQAETTSPHRAGFACFVGRPNAGKSTLTNALVGQKVAITSNRPQTTRHTVRGIVHREDAQLILVDTPGLHKPRTLLGERLNDVVRTTWAEVDVIGFCLPADQKLGPGDKYIVKELAGIKKTPKIAIITKTDLVESKALAEQLLAVSALADELGFEWAEIIPVSAVKDQQVGLLADLIAPLLPQSPPLYPEGDLTDEPEMVMVAELIREAALEGVRDELPHSIAVVVEEMLPRENRPADKPLLDIHANVYIERPSQKGIIIGPKGQRLKDVGTKSRKHIEALLGTPVFLDLHVKVAKDWQRDPKQLRKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJU8</accession>
    <name>A0A7K2ZJU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001203">
        <property type="protein sequence ID" value="MYW32613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="53" mass="5751" checksum="0243DAE238C65478" modified="2021-04-07" version="1">SGGHYRVDAVRAHLLERAGDHDAARTAYLAAADGTLSEPEARYLRARADRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJV6</accession>
    <name>A0A7K2ZJV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_25895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001203">
        <property type="protein sequence ID" value="MYW32611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029805054" evidence="5">
        <location>
            <begin position="27"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="6">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="7">
        <location>
            <begin position="254"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="512" mass="53130" checksum="6E4F7864224526EB" modified="2021-04-07" version="1">MAVVAATALATPLLLGAAPNHGPSHGSGHSKGASKEAVKLSRELVKNASARDAYRHLQQFQAIADSAGGHRAAGSLGHDASAAYVYRQLQRSGYQVSYQTFRFPYTETLAEKLAVVSPTPRDVTIKAMTYTPSTRVGGLTAGLVGVPVDDTSGCEASDYASANFTGKIALIKRGGCTFADKQAAAAAAGATGAVIYNNTEGLLSGTLGEVGAGRIPTGGVSQEEGEQLVADLAGGEVTVSFEVRQLQEERTTRNVIAETRGGKAANTVVLGAHLDSVTEGPGINDNGSGSAGLLEVAQELAESKSKPANKVRFAWWSAEENGLLGSEAYVAGLSEKQRQQIKLYLNFDMIASPNGVQFVYDGDDSDGVGAGPGPEGSAQLERDINKFLDSKGKKHEGTDFTGRSDYGPFIEVGIPSGGTFTGAEGIKTAAQARTYGGQADVAYDPCYHAACDDLSNISMRHFDVNIDVIANAVGTYAHDLRSLTRPVKPVPSTGTPGSGGGLHDGHGHEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK00</accession>
    <name>A0A7K2ZK00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001217">
        <property type="protein sequence ID" value="MYW32668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="234" mass="24908" checksum="6F6B32540CCBC7B8" modified="2021-04-07" version="1">MARQLDEQIAGRFPVGQRLRVLDVGMGRGVQALRLARAGHSVTGLESDAELLRVAREALATEPEGIRERVKLIEGHGRETGVHFLPGSFDVVLCHGVLMYVEEPDPMLAGLARMLAPGGLLSLLVRNADALAMRPGLTGDFGAALAAFDSATYTNDLGLTVRADRLDALRATLAGIAAPLHAWYGIRVFTDNAADGTELPAGELERVLALEDRAGRTDPYRGVAALLHLCGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKJ1</accession>
    <name>A0A7K2ZKJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPOX class F420-dependent oxidoreductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001265">
        <property type="protein sequence ID" value="MYW32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024031">
        <property type="entry name" value="MSMEG_5819/OxyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04023">
        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="42"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19387" checksum="1643A5055C745DB7" modified="2021-04-07" version="1">MRIPFTGPRSRSNTLSPSPDGRATSSQPREYAREKGKALPFTDLELAYLDEQPLGRLATVSPKGQPQTRPVAFSVNRELGTIDIGGYSMGDTQKFRNVRSNPLVSLVVDDIPSTDPWTVRCVEIRGHAEAITGPPTSGFSNDLIRIRPTRILTLGLDENHPKTQTRNIPLPSPDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLB0</accession>
    <name>A0A7K2ZLB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001319">
        <property type="protein sequence ID" value="MYW33108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="336" mass="34908" checksum="CA9796CCA593A2F4" modified="2021-04-07" version="1" fragment="single">MARTGHGPLAGIRVVELAGIGPGPFAAMLLADLGADVVRVDRPGGAALGIDPAYDITNRNKRSVLVDLKAGGGAGRVLDLAERADILIEGYRPGVAERLGVGPDACLARNPKLVYGRMTGWGQDGPLAQRAGHDVAYLALTGTLSMIGKPDEPPVVPANLVGDYAGGSLYLVVGVLAALQHARTPGGAGQVVDAAIVDGAAHLASMIHGMLAAGSWQDRRGANLLDGGCPFYGTYATSDGGHMAVGPLEGQFYAEFIGLLGLADAFPDRWELARWGELRAAVTERFATRTRAEWTETFEGTDACVAPVLSLSEAPHHPHLAARSTFVEHSGITQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLE2</accession>
    <name>A0A7K2ZLE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_28800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001346">
        <property type="protein sequence ID" value="MYW33163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014048542.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6210413"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="193" mass="20697" checksum="27BAF41566B43713" modified="2021-04-07" version="1">MDFASSSGGAARSTTSAKIVVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHTGDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLVDTRRLADCFPAVDYFENSGLPFVIALNGFDGHQPYTPDEVREALQIGPDTPILTTDARHRADAKSALITLVEHALMARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLE6</accession>
    <name>A0A7K2ZLE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP90 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_28815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001348">
        <property type="protein sequence ID" value="MYW33166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="615" mass="66635" checksum="4F93045EBC83B6F1" modified="2021-04-07" version="1">MTLPRPASPDGADRAFQVDLRGLVDLLSHHLYSSPRVYLRELLQNAVDALTARRGLEPDAPEGAFGIRLFADGSVVRVEDDGVGLSEADVHTFLATIGRSSKRADGIAEQRGDFIGQFGIGLLSCFLVADEIHVLSRSARTPDAPAVEWRGHGDGSYSVRTLPASARPRPGTTVTLTPRSDAGEWTRPAQVQALARHFGSLLRHPVAFSDGTAGVPTVSVNPEPAPWARTFPTPGSRARALAAYGEEVFGFAPLDTIELDLPAVGLKGIACVLPEAVPAGRRHGHRVHVKGMLLSEQADEILPEWAFFVRCVIDAESLRPTASRESLYGDDTLAAVRDALAERLRAWIARAAASDPELLGRFLQAHHLAVKSLAVHDDEILRLLLPWLPFETTDGHTTLDEFARTHRTVLVTSSVEEFRQVAAIASAAGLGVVNGGYTYDRELVHRLPEIRPEASVADLDPATLTAHLDPVDRETELAASAYLALARDALAVFDCDVALRTFHPASAPALLVDSREARHERTRSQLAREQEGGLWGDILGALRQEAPRAQLILNQLNPLVRTAVAIDEPELARTSAEALYGQAALLSRRPLRPAESSLINRSFLDLLAHALRKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLM9</accession>
    <name>A0A7K2ZLM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001355">
        <property type="protein sequence ID" value="MYW33228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="64"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="24414" checksum="4E161744606DBBF5" modified="2021-04-07" version="1">MVLLLPDGESASRRRPSSLSYAIQLPFARALARAGEGDGLAVHVLRYRCRGWNDTDAHPAEDAAWAADEVQRRYGDVPVCLVGHGMGGRAALRAAGHGAVTSVLAMAPWLPDHAAAEPEPVKQLVGRRVLIVHGTNDERTDPELSYRLAERAKKSNRDTCRFEVHSDGHALRQHRSEVVALAADFVRGSLFARSYARPVKDALAAPPPLGLRMPLAAGFGRSLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLN5</accession>
    <name>A0A7K2ZLN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aliphatic sulfonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001345">
        <property type="protein sequence ID" value="MYW33159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029576325" evidence="1">
        <location>
            <begin position="28"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="371" mass="39008" checksum="BC2A327FFE62B326" modified="2021-04-07" version="1">MPAHRSTVRRSIAAVAALPLLALAATACGYGSDAKDDDAKKANVSAGGKKLSSDTVKIGYFPNLTHATALVGIQEGTIQKELGGTKVESTTFNAGPSEIEALNAGSIDIGFIGPSPAINAYVKSQGKGLRIVAGSASGGVKLVVNPKKIKTLDDLKGKRIATPQIGNTQDVAFLNWISEKGWKVDPQSGKGDVSVVRSDNKVTPDAYKSGSLDGAWVPEPTASKLVSEGAKVLLDEKDLWPDKKFVITHIIVSQKFLDAHPDVVEAVVKGSVSTNKWINANPEEAKASANKALEKLSGKPLPQEILDPAWESVEFTNDPLATTLKTQSEFSVKAGLLENPKLEGIYDLGPLNKALKAEGQPEVSDAGLGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLV7</accession>
    <name>A0A7K2ZLV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VII secretion integral membrane protein EccD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001371">
        <property type="protein sequence ID" value="MYW33316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="158" mass="16312" checksum="E1E5B1C6700DCAC7" modified="2021-04-07" version="1" fragment="single">MTDSAVAESCRLTVRAPSVTIDLAVPADVPVADLLPTLLRYVGEEAEEAGLDHAGWVLQRLGDAPLDEETTLAQAGLADGAVLHLRPHTEALPEARLDDLVDGIAETVGRRLHTWHAGAARSLLVGTAVATVAAALVLVFRPGVAESTAVRAACAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMB6</accession>
    <name>A0A7K2ZMB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001391">
        <property type="protein sequence ID" value="MYW33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="25736" checksum="F05410C1EFA0A86D" modified="2021-04-07" version="1" fragment="single">MRSGPGQNDRLEALLECWRAIELFGPPSIPALPRRRSLARSGSKDEYIVDLMPQAGPRNVLLPWDDGHPETGARRAPYGRMWRHEVYCGVFDLERLRQAMIAVLPPGTDPDPGVPQSELKVPGQSAMFALVLDEAGRPVEDTSVISASAWATGRLFDPGPSVAGWLDGFEDLDDAFGTAVDELTAAAIPYPAARRGTTDGQRPAAGPEPGSAASRASWQRLLGEILGGAAVGAVDALFGGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMG2</accession>
    <name>A0A7K2ZMG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACP S-malonyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001397">
        <property type="protein sequence ID" value="MYW33459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="2">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="459" mass="47587" checksum="9531B3DAD38BD5FC" modified="2021-04-07" version="1" fragment="single">MTSEPRSEVNGPHRGRSEPIAVVGLSCRLPEASGPAAFWELLSEGRDALTDMPADRWESISGDPVDGIRRGGFIDGIADFDASFFGISPREAVVMDPQQRLLLELTWEALEDAGIVASTLESSATSVYVGTAREDYTSLVYRQGSSAITQHTVTGTHRGIIANRVSYALGLNGPSLTVDTSQSSSLVAVHLACESLRTGESDMALAAGVNLNILGEGIGGAEQFGGLSPDGRSFTFDARANGYVRGEGAGVLVLKPLSRALADGDRVLSLILGSAVNNDGATPGLTVPSGAAQERVIRLARERAGVAPDAIQYVELHGTGTPLGDPIEAAALGAALGTLKADGDPLRVGSVKTNIGHLEGAAGIVGLIKTVLSIRHRMLPPSLNFETPNPDIPLGELNLAVNERLSPWPRPDRPLTAGVSSFGMGGSNCHVILTEAPARPADPADPDPAAVDPAADPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMP1</accession>
    <name>A0A7K2ZMP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="19076" checksum="10F77F10757B80FB" modified="2021-04-07" version="1">MNVAEVYALAAAAHAGQFDKIGVPYIEHVRAVAVGLVSFGDHLVMAGLLHDIIEDTDWTGERLREAGVPDHVVALVEAVTNERGVPYEEKVARITGHGRDAVLLKVADNAHNSHPDRAVKLPKGQRTRLAAKYRAARDILWPAVEDRDIETIVRIVNPSLLDELRERQNSGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN16</accession>
    <name>A0A7K2ZN16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001452">
        <property type="protein sequence ID" value="MYW33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7725" checksum="451F19040E043044" modified="2021-04-07" version="1">AAAALVRPRLEDWQRRWEEGARAAAETTAAQLEALRGHDEQHLTRALVASTGPTAHGRFGMCGRLAVYQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN23</accession>
    <name>A0A7K2ZN23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hisI</name>
        <name evidence="9" type="ORF">GT040_31940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001453">
        <property type="protein sequence ID" value="MYW33756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="13577" checksum="8DDFD4CB2B93CB20" modified="2021-04-07" version="1">MTSTPGPTPPASSLDPAIAARLKRGADGLVPAIAQQYDTGEVLMLGWMDDEALHRTLTTGRATYWSRSRQEYWVKGETSGHIQRVKAVALDCDADTVLVKVDQTGAACHTGDRTCFDADVLTLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN30</accession>
    <name>A0A7K2ZN30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001451">
        <property type="protein sequence ID" value="MYW33747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029766467" evidence="1">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="20846" checksum="174D21B8C78C27A8" modified="2021-04-07" version="1">MRKKASAAVIGLAIAGVSVLATTSASSHGYTDSPISRQKLCANGTVTGCGNIQWEPQSVEGPKGFPASGPADGKICSGGNGQFAQLDDPRGGNWPATQVTGGQGYSFRWQFTARHSTSDFRYYITKNGWDSTKPLTRAALESQPFMTVPYGNQQPPATLTHQGTIPTQKSGKHIILAVWNVADTTNAFYACSDVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNF6</accession>
    <name>A0A7K2ZNF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Na+/H+ antiporter subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_32485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001487">
        <property type="protein sequence ID" value="MYW33862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="131"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="551" mass="57868" checksum="93E99E45C3383467" modified="2021-04-07" version="1">MNALVPLPVLLPLCATGLSLTFGTRMQRFQRFISVAVLTAVLALSIILMIAADRQGPLSVHLGDFAPPLGITLVADRLSGLMLTVSSAVTLCVLIYSLGQGMTDRDKETPLAVFHPAYLILVAGVSSTFLAGDLVNLFVSFEIMLVASFVLLTLGGTGPRMRAGSTYVIISLFSSMVFLIAIAMTYAALGTVNFAQLAERLPGLSLGVQTLIQAMLITVFAIKAAVFPVAAWLPDSYPTAPAPVTAVFAGLLTKVGVYCMMRTETLLFPGNRIGDLLMAVALASMLIGILGAVAQTDLKRLLSFTLISHMGFMVFGIGLATREAYGGAIVYVVHHITVQTSLFLVAGLIERRGGTTELTRLGGLAKAAPILALLFFVPAMNLAGIPPLSGFIGKLGLMRAGVADGSVWAWILVAGSVVTSLLSLYVMAKVWNLAFWRAAPPGQAEAGTVLESQDDSDDDTDEGPDGVPGTGDEGIEPVRRPAGGAVVATKPRQTSVITTSRLPRPMMAATAATIALALAFTVFAGPLTAFTDRSAAELLKRTPYIEEVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNH4</accession>
    <name>A0A7K2ZNH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001490">
        <property type="protein sequence ID" value="MYW33882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029581181" evidence="2">
        <location>
            <begin position="26"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="16388" checksum="F3ADE3FD3BFBFA86" modified="2021-04-07" version="1">MRRRILTATVPLAAVLLVGGCSGSADTGTPEGAGSKTSPTASEPAASPTPPSSPGGTSAPALEYPEKAQALVPETSGAGDKNLPAFTPAEETYTIYADCTGKGSVSLVDRDNPDGKPHPISCDGVPTVGVIHTEAVPQRLMVKVTGGAAQWAIAILSGDKRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNK0</accession>
    <name>A0A7K2ZNK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001496">
        <property type="protein sequence ID" value="MYW33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="20251" checksum="B425D21DF17EE2C4" modified="2021-04-07" version="1">MDTATPPGSARLTFRDATDADAPALVALIESAYRGDSSRTGWTTEADLLEGQRTDEEGVRAVINAPAGRLLAVERDGGLIACCQLEHRGEAAYFGMFAVRPDSQGGGLGKVIIAEAERTARESWGVAEMHMTVISAREDLIAWYERRGYRRTGQFTPFPYGDVRFGIPQRDDLAFELLVKNIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNL3</accession>
    <name>A0A7K2ZNL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M48 family metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_32875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001499">
        <property type="protein sequence ID" value="MYW33935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="129"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="24707" checksum="2592F0F26453FF16" modified="2021-04-07" version="1" fragment="single">MGVFVYLPLVLPLTALPIARLAEQHLHPRRAARLLTTVAVILASCSLVCLGLLVVVGTAQLPGNPLPDGWSDDEVREAVPHDAFAGKASILALVAVTMTCGFTVHRHYRFRARAHRTLAGLPGGGDLAVLPDDVPYAYALPGSPGRVMVSTAMLAALDPAERRALLAHERAHLDGRHHRLLLATRLAGCVNPLLRPLQEALVYSTERWADEEAARVTGDRRLTARAVGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNL4</accession>
    <name>A0A7K2ZNL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_32515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001487">
        <property type="protein sequence ID" value="MYW33868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="27"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="420" mass="44536" checksum="AF743B039D4BEC67" modified="2021-04-07" version="1">MSDVERHRPFLNRRLLVVSTNYAPEVTGIGPYATQLAEHWAASGARVRALTGMPHYPSWQLDEAYRSVWRTVEIRGGVGVHRRRHYVPPRQTALKRAAFEASILATGLFAPPPGRPDAVIAQMPSLAGGVIGARLSRRHRVPYVPVVQDLMGAAAAQSGIRGGGRAAAVAAAAERYALSGAALVGVIHESFVPGVTALGVDPGRIRLVPNWTHVQGPTADRAATRARLGWDPETPVLLHSGNMGLKQGLEVLIDTARLARDVRVVLMGDGNQRDALRARAEGLPNVDFLEPAGAAEFTDVLAAADVLAITQRASVLDMSVPSKLTSYFVSGRPVIASVADEGGTADEVRRSGAGVLVAPEDPAALLETVRKLAADPAAADALGAEGPRYVARHLSREAGLARFDDLLAETLRDGQGSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNU3</accession>
    <name>A0A7K2ZNU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1416 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001502">
        <property type="protein sequence ID" value="MYW33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003968135.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="63981598"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010814">
        <property type="entry name" value="DUF1416"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07210">
        <property type="entry name" value="DUF1416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="9635" checksum="E0E0A3765B86A48D" modified="2021-04-07" version="1">MCGAQAGGPDASTIKPGETTIQGSVTRDGEPVTGYVRLLDSTGEFTAEVPTSATGQFRFYAAEGTWTLRALVPGGSADRTVVAQTGGLSEVAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP05</accession>
    <name>A0A7K2ZP05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001543">
        <property type="protein sequence ID" value="MYW34104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="40"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="18055" checksum="C6322C7067439DD1" modified="2021-04-07" version="1" fragment="single">MSLLELDGVKVHFPVKKGLFFDRTVGHVYAVDGVSLSVEAGQTYGLVGESGCGKTTLGRAVLRLNDITDGAVVFDGTDLAQLPSEEMRSFRRRLQMVFQDPLGSLNPRQNIESILAEGMAAHDIGKDQAERREKIKEILAKVGLPANAMSRYPHEFSGGQRQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP46</accession>
    <name>A0A7K2ZP46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_33855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001547">
        <property type="protein sequence ID" value="MYW34126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="132"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="132"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="25161" checksum="6B913583396D0A15" modified="2021-04-07" version="1">MRLLLVEDDDHVAAALSAVLARHGFQVVHARNGEEALRALLPAEKEPFGVILLDLGLPDQDGYEVCGKIRKRTATPVIMVTARADVRSRIHGLNLGADDYVTKPYDTGELLARIHAVARRTTSGEDTAPTPVAALRLGSVAIELPTRRVSVDGAEVQLTRKEFDLLALLAQRPGVVFRREQIISEVWRTSWEGTGRTLEVHVASLRSKLRLPALIETVRGVGYRLVAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP96</accession>
    <name>A0A7K2ZP96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid deaminase/aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001558">
        <property type="protein sequence ID" value="MYW34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="25"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="400" mass="42561" checksum="75CC2D728DABFB44" modified="2021-04-07" version="1">MTARAADRTRYNRATAHLDAPIAIVDLDAFDDNADDLVARAGGKPIRVASKSVRCRVLLERVLARPGFAGIMSYTLAESLWLARAGFEDVLLAYPSADRSAFAELAADPKLAAAVTVMVDDHSQLELIDASRAGGQEEIRVCLELDTSLRLLGGRIRIGALRSPLRSPAQLAELARSVARRPGFRLVGLMAYEGHVAGVGDSLAGRPLRSRAIRLMQTTARKELAARRAEVVRAVRAVAPDLEFVNGGGTGSVQHTAAEAAVTEIAAGSGLYVPRLFDNYTSFTARPAALFAQPVVRRPGVGVVTVLGGGYPASGAAGADRSPVPYLPEGLRYDPQEGAGEVQTPLLGSPADDLLIGDKVWFRHAKAGELCERFDALQLIEGDRVTATVPTYRGEGKTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPA2</accession>
    <name>A0A7K2ZPA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001555">
        <property type="protein sequence ID" value="MYW34186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="429" mass="45506" checksum="E20369D5E0A50FFC" modified="2021-04-07" version="1">MSVDDTNLLPQKRHEGPLPSPWRSNRFRLFFTARSASLLADGMLMVSLTTAVLGAGHGASGVGYALAAWMTPIVLLVLFGGVLADRFTPQLMMICADLVRMLAMITLGALLFFSDSVPLWQIMGLMALSGAATAMFQPGMASMVPRVAEDIQKANALLRISEALSTLLGPGLAGILVAYWQVSGSYLVIAAAYALSALVLLPLRKLHTERDEGDDPMWRRLATGWQEFRSRQWLWGVIAVWSVYGLFVFGPALPLGAALMIEQHGASGYGWIASADGAGTIIGGLIGMRVRPRRPLVAGALAMLCFALNPLAPALEWSFAATAVAHVVAGYGFAFWGVMWATSVQSHIPLTVLSRVSAYDVAGSIMVIPLGRALAGPAADAFGANEVLIFSSVISLVLLAAMLSIPAIRALRRAPEVIALKPGGEQPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPR9</accession>
    <name>A0A7K2ZPR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_34960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001595">
        <property type="protein sequence ID" value="MYW34340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="17802" checksum="DC5378A1A74E5131" modified="2021-04-07" version="1" fragment="single">MLDHSELLVVGECVADIVRQPDQEDRVHPGGSPANVAYGLARLGRRATLLTQLGPDPNGRLIRDHLAAAGVTVRTDGSATATPSAVVTLDGAGRASYAFDIAWTLVPVTVAPASGHVHTGSIGAVVEPGSATVLDIVRGARATATVSYDPNVRPALMGDHAAAVARVEECVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPW7</accession>
    <name>A0A7K2ZPW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001606">
        <property type="protein sequence ID" value="MYW34382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7171" checksum="5988A39736470469" modified="2021-04-07" version="1">MMTESPRWFTSSYSDNGGDCVQLAVNLVASQGIVPVRDSKCVDGPVVDVRTAAFSAFVAGVQAGTFDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPZ2</accession>
    <name>A0A7K2ZPZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_35470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001623">
        <property type="protein sequence ID" value="MYW34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015607899.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001623.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="25798" checksum="DF4DE61E5E9399B4" modified="2021-04-07" version="1">MTALLEVEDLRVAYGKIEAVKGISFKVEEGEVVTLIGTNGAGKTTTLRTLSGLIKPLTGQIKFNGKSLRKVPAHQVVSLGLAHSPEGRHIFPRMSIEDNLRLGAFLRKDSDGINKDIQRAYDLFPILGERRKQASGTLSGGEQQMLAMGRALMSQPKLLMLDEPSMGLSPIMMQKIMATITELRAQGTTILLVEQNAQAALSLANHAHVMEVGNIVLSGTGQDLLHDDSVRKAYLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ49</accession>
    <name>A0A7K2ZQ49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001627">
        <property type="protein sequence ID" value="MYW34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7519" checksum="6CF09454BA71A5E9" modified="2021-04-07" version="1">MADDNTVKMKLTFPRGKQMPGEIVEVAADEVHRWKGYAEVVDDKKADEAAKTAGDKNPTTGSVSQKAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQD6</accession>
    <name>A0A7K2ZQD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001643">
        <property type="protein sequence ID" value="MYW34584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="29302" checksum="AEE70A5BAF24EB2D" modified="2021-04-07" version="1">MSSWQGGPSWGPGDNGTPGDSGTPDWAALAEASAARTRRKRWLMIGGGVLATAVVGAVVATAVVTTGGKSDPAGNASELPAPAELPEDTSAPAPSFSSVAPPPPPDPKEYISSAAKDKAPITVDGFFPGKKLAMGDRVHLKGATNRTTACATGTQGALGAVLTKNGCQQLIRATYRKDGVAVTVGIAVFATEARAKKTVDEVSGGLASLSGAGVPTFCRGGTVCRRTTNSYGRYAYFTVGGFTDGTRVTLQDKNVFAVGDDLTNFVFRQIHQRGRVQASQAAEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQF2</accession>
    <name>A0A7K2ZQF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001639">
        <property type="protein sequence ID" value="MYW34555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="167" mass="17542" checksum="EEFAFA11BC5F3E06" modified="2021-04-07" version="1" fragment="single">MSAVRRLVVEADGGSRGNPGPAGYGAVVIDAATGETLAEAAEYIGVATNNVAEYRGLIAGLTAAKALFPDVGAAGPDLEVHVRMDSKLVVEQMSGRWKIKHPDMKPLAARAAAILPPSSVTYEWIPRAQNKHADRLANEAMDAGRDGRQWEASASTAELDAPARTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQU6</accession>
    <name>A0A7K2ZQU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_36960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="20"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="441" mass="46469" checksum="54E980AF658EBFF9" modified="2021-04-07" version="1">MSVAGLRTAARETVSGLPREFWWLWLSTLVNRLGGFVATFMALYLTLDRGYSASYAGLVAALHGLGGVISSLGAGVMTDRLGRRPTMLIAQLSMAVSVAVLGFMEHPGAIAAVAFFVGMASNASRPAVQAMMADIVPPKDRVRAFSLNYWAINLGFAVSSAGAGFIAEYSYLAGFLGEALMVLACAVVVFLKVPESRPAQAAPVKTAGGKRAKDEVRITTVLRDGRFMGVVGLSFLVSLIFQQGYVGLPVAMGADGLSSSDFGTAIAVNGVLIVALQIPVTRFIQHRDPRRLLIISSLLAGYGFGLTAFAGSVAVYALTVCVWTLAEIVNAPTQTGLVVQLSPAQGRGRYQGMYTMSWSVAALVAPLMSGFVIDHYGAAWLWGACAVIGTVAGLGYWLLMRNLPREEILADEAVPEPAPVPAQARPDQAEPDPAPAIERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR43</accession>
    <name>A0A7K2ZR43_9ACTN</name>
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        <submittedName>
            <fullName evidence="3">Zinc-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">GT040_37505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF17032">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="18"/>
            <end position="74"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="104" mass="11549" checksum="FAF60AEFD41310C3" modified="2021-04-07" version="1">MIIFGTKGYLYQLAILTMVCGWCGNPAAHTLRKRVTKFTLFFIPLFPFSTKYATQCTFCGGEQQISKEQADQLLAQHAAGLDGGHGQHPQQPGFTQPGQNPYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR76</accession>
    <name>A0A7K2ZR76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_37400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001690">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="36"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="48"/>
            <end position="66"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="141"/>
            <end position="160"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="19109" checksum="41FD79D7AF8BF99A" modified="2021-04-07" version="1">VWGAAAVALTLSVPLSLACGLLAGTVHLAAVAAAWLYNLRLKATVLSWVPYAAGFAALPSLVTLSLPDGPWPRWWTVAAGALLGCAAHLGDTLPDIEADRAAGIRGLPHRLGARGTRLLLPVPLLAATGVLVLGPPGPVDAGSLAVLVLAGAAAPLGPALGRWWRKAALAGAVTVAAADLALLLTRGTALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRM1</accession>
    <name>A0A7K2ZRM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001738">
        <property type="protein sequence ID" value="MYW34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="11447" checksum="20B4AB4E47D64EE9" modified="2021-04-07" version="1">MLDGAARCFARSGFHGTSMQDVLKEVGLSAGAVYRYFPGKEDIIAAITEETFATIRGAFAEAGRMARTMIATAQGFIVQEALFGDVHPEVLESGLRGLMSMGRQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRP0</accession>
    <name>A0A7K2ZRP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNP_UDP_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001741">
        <property type="protein sequence ID" value="MYW35003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="394" mass="40611" checksum="31F6BA35D0EB96BA" modified="2021-04-07" version="1" fragment="single">MTELRVGLIVPLSEEFGYVSSVVDLLGDFREQGRVYHSFLVPGTEITGLLTVLHEMGQSNAAIAAQDLIRVFGVPLVALIGTGAALSSEVALGDVVVASEIDAYLHRAKAVGEAEHPGGAGLALAGTSWKPSAPLLDLVRNFPLRKASRDVVTAWSGDALARCPLPVGLRPAAGPGLHVAPVATGDVVVGSDTFKAVIRNKNRTLAAVEMEAGGAALSAYHSDTADVLVVRGISDHAAKDKTATDLTPDVDGRPNAWRRYAVTNATRILLKLLAAPDFPWRATSPARGPVSPAPPRRPEPGPSRGDGAESGPAVDGRSPDGRRSGKGWLDGRTVAAVTSGAATALAVESLLHRRRDIEEALSAASSPPAPEAGSHAARTESADGPDGSDGGSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRQ5</accession>
    <name>A0A7K2ZRQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001744">
        <property type="protein sequence ID" value="MYW35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="155" mass="16134" checksum="027E0BB367FB316A" modified="2021-04-07" version="1" fragment="single">MGVSLAKGGNVSLSKEAPGLTAVTVGLGWDVRTTTGADHDLDASALLCSAAGKVLSDAHFVFYNNLNSPDGSVRHTGDNLTGEGEGDDESVEVDLASVPAEVAKIVFPVSIHDAQSRGQSFGQVRNAFIRVVNRANGVELARYDLSEDASTETAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS24</accession>
    <name>A0A7K2ZS24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001751">
        <property type="protein sequence ID" value="MYW35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="450" mass="47548" checksum="F3D40A5978F420E5" modified="2021-04-07" version="1" fragment="single">MGTTTPPRTLAEALRARGDESLAGLLRARPDLLNPVPNDITQLATRAGTRASVVRALEHLDKFALQTAEALAVAPDPAPYATLLSLLTGDGLDDGEQRDDVGAAVTAALPGALATLREQALVWGEDERLRLVRTARELLAPSPQHPSPTGLGPTVAEATAGMSPGRLQEILVASGLPATHDPVSAVAALSSLFTDRTRMAELLDTAPVEALSVLDRLVWGPPYGEVTPNPTPPVKWLRDRGLLLPVSTRTVVLPREAALHLRAGRAHRVPEPVPPVVAAAAERDPQAVDRAAAGQAFTALSTVEELLKLWNGGGPAILRAGGLSVRELKRVAAALEVTEPIAAFWVELAYAAGLLASDGESDERYAPTPAYDEWLDLPAQDRWTHLATAWLPATRVPGLVGGQDAKGRALSALGPELDRSAAPDVRRRVLALFAQLPPGTAPDPETLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS38</accession>
    <name>A0A7K2ZS38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001782">
        <property type="protein sequence ID" value="MYW35165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="105" mass="11454" checksum="131E09F864C52694" modified="2021-04-07" version="1">MADAEFSASGVRIERFTRSLTRAGQVVVKDGRLSLLTSNGREIDSAPVGTVSAGKRWFFAADSAIARVNGVRYRLTMGQRSRRRDGAAPLRRFLEALRSAGGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSD7</accession>
    <name>A0A7K2ZSD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001832">
        <property type="protein sequence ID" value="MYW35304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029866949" evidence="1">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="423" mass="45066" checksum="53BCD146047345EB" modified="2021-04-07" version="1">MRRGITATALVAALALAATACGSGDETGGSKSSGELSGTVTWWDTSSVGSEDKVFKKLAEGFEKKHPKVDVKYVSVPFGDAQNKFKNAAQAGSSAPDVIRSEVAWTPDFASLGYLAPLDGTAALKNQDDFLPQAVASTKFEDKTFAVPQVIDSMGIFYNKKLMEKAGVEPPTNLDELRASAKKIKDKTGKTGLYLRGDDPYFFLSFLYGEGGDLVDAETKTVTVDKPEGVKAFKAVKALVEDGTAKTDASDGWENMMQAFKNGDVAMMINGPWAVADTLTGKEFTDKDNLGIATVPAGSAAHGAPQGGHNLAVYAGSKNLEASYAFVEYMTSVESQATTAGELNLLPTRTSAYAKKEAVNSEIVGFFKPVVETAVERPWIPEGGSLFAPLGIEYTKVLTNQTTPEKAAKATGDAYRKLLKDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSI0</accession>
    <name>A0A7K2ZSI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_39365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001785">
        <property type="protein sequence ID" value="MYW35179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW35179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="270" mass="28495" checksum="E59551E51A91EE0D" modified="2021-04-07" version="1">MTTTTVLTGPRKSPSKASASARRLTALARAELILLVRNRSAIFIALVLPIVMIFSIRASLQQIDLAGTGLSIAGAALTGGIGIVLVQVVYMTLVTGYVTRREELVLKRLRTGEVTDREILAANALPAVALALLQVVLLVAAGAVAFDLSAPKRPEIFLAGLLVGLVMMSGLAAATSAVTRTVQTSQLTTLPLFFVSLFASGIFVPLEIFPDGLASAFELLPLTGVMTLIRHGWLGGVEGGDLLTATVAALAWTGFAVFAVQRWFRWDPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSJ0</accession>
    <name>A0A7K2ZSJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="126"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="303"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="472"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="695" mass="74088" checksum="98B619D4247C800B" modified="2021-04-07" version="1">MAGPAHLLEAANPAFFAAIGGIERTRTGVPLGQLMPELVEQGFIALLDRVYRTGAAYTGRDARVMLGEGADAREGFFDFTYEPRLDSGGNVMGVRMIGVETTQVKHAQRLTAEHRALLEQIARQAPLSEVLEGMARAIEDLTPEEVLVSVLLADADGRRLRHGAAPSLPDFYNQAIDGIATGEGVGSCGTAAHRRRPVIVTDIATDPFWDDFRDLADKAGVAACWSTPILARDGSLLGTFAMYHRVPRTAQETDLALARVFAGTAALAIERHQVEQAYLAAEAREKTARDDLAFLLNASTLLTADLDVAQTLNRLAQACSPRLAPLCAVDVIEGGRVRRVATAAPAQWQQDLLADHAPVYDDTDDAVARVLTSGVTEVARRTPTGPGPWHDLGVTGYVCIPLLDRDSVVGTVTLLSTDGYTFDGHTVALAEELAGRAALAARNARQYTHRAVLARDLQAGLLLPELPCVPGTEVATYYHPAGEGLDVGGDFYDVFPLSDGRWAFLLGDVCGRGAIAATTTALVRHTARAVAPLVPGPQEVVEAVNQALCNRPVGHGTGFVTLVYGRITPTDDGLDVELVRAGHTLPLHLDAHGTVRAVDAPGVLLGIGPQTHLTARNLRLRPNESLVLYTDGITEARRHDNELFGDRRLADAVADAPARPAAQQLIDTVTHAVHTFTGDHGIDDDQAILVLTATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSM0</accession>
    <name>A0A7K2ZSM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_40270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001836">
        <property type="protein sequence ID" value="MYW35343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="3">
        <location>
            <begin position="228"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="509" mass="55081" checksum="E873AC3744A49ECF" modified="2021-04-07" version="1">MEWFSAENVVAVLTAVLGVLASIGVLWYERRVPRRKRIGYRVQMDTPIGSDVSQGRANVRLGLFSETPEMSDATLVLLRVENDGSQSIVDSDYTGREMHGLTAEFTGRTVRGVAVTQPPGAAHLMEHFTAAAGMRLSGSLIRLPRVPLNRGEHFKLLVLLTGADVGSPIRITGGIRDGEVTVNRAARPDDKPPLFGRAARLITVTLTVCVMALAAIILVRDDTPPPLDCARGELRVTGSTAFAPVVRELAATYMKECEGSRIEVDPHGSNSGIRELSDEGARAGKSGSPGLVALSDGPKPPGHPELRETRVAVSLFSLVVNDRVPVRDLALADIRRIYAGEIRNWRELGGPDLEILLVSRDANSGTREVFQRRVLDRNEPAQSSRDCATKDDPRAPVTRCELDGTDQVLATVARLDGALGYSELRSGSEPRGLHRIAIDGAHPSVDTIGTSPYPYREIEYAYTYGRPPADSLASSFLGYLSRGRGQDVIHIHGHLPCATPRGLRVCGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSU6</accession>
    <name>A0A7K2ZSU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_40715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001850">
        <property type="protein sequence ID" value="MYW35426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="3">
        <location>
            <begin position="84"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="459" mass="47331" checksum="AC55674A87232DDE" modified="2021-04-07" version="1" fragment="single">SGRTPKALDAQAARLAAQVAADADMTPAAVGRSSVSTRSLFAHRGVVLAADQDELLAGLQALGGRLPAANVVSGSEVGGRLGMVFTGQGAQRVGMGTELYAAFPAFAAAFDAVCEHLDPLLERPLREVIASGEGLDLTGSTQPALFAVEVALFRLYESWGVRPDFLAGHSIGEVAAAHVAGVLTLADACVLVAARGRLMQALPEGGAMVAVQASEAEVLDALSGHEAAGSQAVSLAAVNGPAAVVLSGDEAAVLEVAGGLRERGHKTKRLTVSHAFHSAHMDGMLDAFRRALAPLSFHPPRIPVVSTVTGEVAADGLLESPEYWVEQVRAPVRFLEAVRTLEAEGVRTVVELGPDGVCSAMVAESVLDRDAVHAEPALRSGRPEDRTAGAALARAFVRGAEVDWDAVFAGTGTHRVELPTYAFQRERYWVTDLPAPAAGSSPAAAAVNARPTTASSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5T8</accession>
    <name>A0A7K2Z5T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_00065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="73"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="384"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="418"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW27706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="626" mass="65847" checksum="814D209BD2B26656" modified="2021-04-07" version="1">MSAVAGTTTGAGRRPEGAEGQGGPGGHGGPETHGGPEAPEESAPPSEAATTCPSPLRLLLTRVRPHRGVLIRAGLLSLTGSAAGLAMPLTAKYAVDAFAADRSPVTPLIALTALVLAGACLSAYGRYLMARTGEGVVLRARHQLVGRIMRLKVPAVDRLTPGDLQSRVTSDTTLLRTVLSSGLVESFNSVLMLLGTIAFMAYMDVTLLGVTLVVIVGIGAVTALLMPRIQRAQLRAQESVGAMGAALDRVLQAFRTVKASGAEERETAAVAEAARHAHDRGVSVAKWSSVSDVTMMMSIQLAFLAVLGVGGARVASGSLDISSLIAFLLYLFYLMGPIGGLVEGWTGLQSGLAAVRRIDEVESLPGEPVEGFSGLKSGGGPLRVSFQDVAFGYGDERAPAHKGVTFEVPAGGMVALVGPSGAGKSTVFSLLERFYDHDAGAIALDGRDIRDWPLVELRASLAYVEQDAPVLAGTLRENLLFAAPDAPEDRLTEAVARTRLDALVARLPDGLDTAVGHRGVTLSGGERQRIAIARALLRRPRLLLLDEVTSQLDAVNEQALRDVILELAEQTTVLVIAHRLSTVRHADRIVVLEEGRVRTAGTHEELIASDDLYRELATTQLAAEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Y7</accession>
    <name>A0A7K2Z5Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_00330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000008">
        <property type="protein sequence ID" value="MYW27756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029735207" evidence="2">
        <location>
            <begin position="34"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="53"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW27756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="36317" checksum="DBC077CC00B3B62D" modified="2021-04-07" version="1">MPETSRRGLLFGAAAVSTGALLTACTSNEPKSAQPAGNSQPAADDKPGKPVTIGFAGPQADHGWLNAINVNAKSRAEKYSEVTLEITEGSNDTAAQIGQVKTLINKKVDVLVILPADGKALTQVGLEAMRAGIPVVNLDRIFASPQAYRCWVGGDNYGMGLNAGHYIGEQLKGKANAKVVELAGIDNLELTKQRSQGFADALKNYSNIKLVARQAADFTVESGQAKMAQLLQAQKQFDALWNHDDDQGVGALRAIQQAGRDEFIMVGGAGAKSAMDAIKADNSVIKATVLYPPTMAASAIDLARALGQSKGISGLSEMEIPTSLTLYSAVVTKDNIDQYLPTGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6B9</accession>
    <name>A0A7K2Z6B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000031">
        <property type="protein sequence ID" value="MYW27853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="487" mass="52511" checksum="41196694BD9D9344" modified="2021-04-07" version="1" fragment="single">APATAPATPDPAGSDVFGEWLRSMGGITDLDAPVAETPDRGDGVPLETQLERHRPARLLTGEDARPPGPAPRTVTFDDGSRLPTVLISPDADPDDGGTGPGTRTDGAPRTGLLNGLGVLNLRSPEQVAKEVFDQLPKKLRSQFDEAELLRLLKDQPGAFTAPRGARFVGREKSGVGHEMVVEAVPYHRWERFSEPGGATVRVDTVRRGQSGTGGGRSVGVGRRIAAGLGMGPPLNWLLKIGVSLGWNRKTDYTQGTQAYHQSEYRAWEGSHLHLDDVHYRVRVERVTEAPRTPAPGTPPTAPHWQRSEVHSASFAMRDGLSWRLPDDLTVPFNGPKRAPETLTFPNGAEPRITDTTALHLTDPPENVALAISGARPGSSAHRTLVSYVRPGRLLGLFGRLSGPVTGPELTRGSGQHPLGHLIVERSIPHRATLVTESVKSEIRDLTQTTYQNQRAHVRDTRLGVQVTAGPNYTLIGPETDVRLQGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6M3</accession>
    <name>A0A7K2Z6M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000067">
        <property type="protein sequence ID" value="MYW27995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="459" mass="50667" checksum="C30E5A86C8805E6D" modified="2021-04-07" version="1">MGNPIAVSKDLSRTAYDHLWMHFTRMSDYENAPVPTIVRGEGTYIFDDKGKRYLDGLSGLFVVNAGHGRHELAETAYKQGQELAFFPVWSYAHPKAVELAERLADYAPGDLNKVFFTTGGGEAVETAWKLAKQYFKLKGQPTKYKVISRAVAYHGTPQGALSITGLPALKAPFEPLVPGAHKVPNTNIYRAPLFGDDPVAFGRWAADQIEQEILFEGPETVAAVFLEPVQNAGGCFPPPPGYFQRVREICDKYDVLLVSDEVICAFGRLGTIFACDKFGYVPDMITCAKGMTSGYSPIGACIVSDRIAEPFYQGDNTFLHGYTFGGHPVSAAVGLANLDIFERENLTQHVLDNENAFLTTLQKLHDLPIVGDVRGNGFFYGIELVKDKATKETFTDEETERVLYGFLSKALYDNGLYCRADDRGDPVVQLAPPLISDQSTFDEIESILRAVLTEAWTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6N6</accession>
    <name>A0A7K2Z6N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3046 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000069">
        <property type="protein sequence ID" value="MYW28009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="7351" checksum="CC317153B86B5AF1" modified="2021-04-07" version="1">MRLTIFWERMADHFGAVYADSFARDHVMAELGGRTVHQALDAGWDAKDVWRAVCRTMDVPADKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7N4</accession>
    <name>A0A7K2Z7N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="12237" checksum="9C5A3C99FCB2A79A" modified="2021-04-07" version="1">MAPEIVIAVITAASVLGAAVVAALPALMTALRRTRSAVGAVEESVQAQGAETRAATVDAMACVASQIEAVASRLDSRIDDVRDDIDGVRESVARVREWQAGHDAEHLLIPNPRPGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7V5</accession>
    <name>A0A7K2Z7V5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">coxB</name>
        <name evidence="18" type="ORF">GT040_03880</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000163">
        <property type="protein sequence ID" value="MYW28434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="17">
        <location>
            <begin position="137"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MYW28434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="322" mass="36097" checksum="03E624752914E4C6" modified="2021-04-07" version="1">MSPNGSDRSSRRPMRRKLPQVLTAGLVLATASGCSYNWEDFPRLGMPTPVTEEAPRILSLWQGSWAAALVTGVLVWGLILWSVFFHRRSRTKVEVPPQTRYNMPIEALYTVVPLIIVSVLFYFTARDESKLLELSDKPAHTVNVVGYQWSWGFNYIEKVEGQPAAGGEVPKELAAIPQKFQDDFPKDATGVYDAGIPGTRNPQNGNPGPTLWLPKGEKVRFVLTSRDVIHSFWVVPFLMKQDVIPGHTNVFEVTPNREGTFMGKCAELCGVDHSRMLFNVKVVSPERYQQHLKELAEKGQTGYMPAGIEQTDPARDSEKKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z803</accession>
    <name>A0A7K2Z803_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent F420 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000189">
        <property type="protein sequence ID" value="MYW28487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="47" mass="4792" checksum="CC5441BB8A50386B" modified="2021-04-07" version="1" fragment="single">MTTQDSGSAPKPPAKDPWDLPDVSALSVGVLGGTGPQGRGLAYRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z867</accession>
    <name>A0A7K2Z867_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000199">
        <property type="protein sequence ID" value="MYW28544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="113"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="407" mass="43285" checksum="96564614B5D77311" modified="2021-04-07" version="1">MTIAALESLSFGLGRMAEAAAETGHRLCLLTGDRSVYRHELATLPADALDVVDVDTDDPEAVRRALADLPSLSGLINTTDTWSVPAASLAAGLGLPGPDPEAVRLLRDKRRVREALYERGLSRSAAVAVEPGPEGAEAVLRTIGLPAVLKDSAGTSSRGVWIVHDEEALHRALAEAERQPLKGALFAESFLAGPLYSAETLSWEGTTRLLGVLSRQTSRSAVVREEVAAFPVALPDGERDAVEAWVGQVLEVAGHGRGFAHVEFILTSEGPELVEINRRIGGALVGEVLCRTLGTNVYTAMMDEALGRRPRLLDAPLDGQGPAYGFVLVYADRPGVLKGWHGLDELAAFPGSVEWYPVREPGETLAHVGDQRGCTGMVLAEAATAELAQHRAWSAAVRVRPVIADTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z876</accession>
    <name>A0A7K2Z876_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000197">
        <property type="protein sequence ID" value="MYW28522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010866">
        <property type="entry name" value="A-2_8-polyST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07388">
        <property type="entry name" value="A-2_8-polyST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="458" mass="49219" checksum="DB11B4BEDBF1EBF5" modified="2021-04-07" version="1">MSTAPAPRTTQLLSASTLHGAATLAAALDTGCFGPADRRVLVVCDNAAVPEAGPALDALPGFERLRGRFDDIVSWNGTIAPFHPSGWSPRPDDVPLWERHLRLAWGLGDDEVELAVESIEVSPALAIAEIFAGAPVDVYADGLTGYGPTRDKLDPLIGTRVRRLLHLDLVPGLKPLLLTEFGVEPLVVEAGGFLKVLGELADAVPVELPSVESPALLLGQHLSAPGLITAAEEEELYLRMVRGAVALGHTRLVFAPHPAAPARRSRSMEEEAERLGAELTVLDTGILPDPVLAEVLCRRMRPALVVGCFSTALLTASAFYGLPVARVGTELLLDRLSPYESGERMPVTLVDALLPELGDRAAVVERRPSDGAEREVAALVAAVGFAMRPRLHPGLRPAAERYLSTRLTPVTWRYFKRRRLTQLGLPGGVPARFMFLSRSAAVRGAVRRARSLRRAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Q8</accession>
    <name>A0A7K2Z8Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urea ABC transporter permease subunit UrtC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">urtC</name>
        <name evidence="8" type="ORF">GT040_05515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000250">
        <property type="protein sequence ID" value="MYW28740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017778">
        <property type="entry name" value="ABC_transptr_urea_perm_UrtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482:SF4">
        <property type="entry name" value="PTHR30482:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03408">
        <property type="entry name" value="urea_trans_UrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="386" mass="40117" checksum="4771DB14E9B8576C" modified="2021-04-07" version="1">MTTTSTPPTAAPATEPTAGPPETPFLGRFLGRFRTPAAFALGALLLVGVAPLVLSDFRLGLLAKYLCYGIAAVGVSLAWGRGGLLVLGQGVFFGLGGYAMAMHLKLADAAATGETLPDFMLLYGTEGGLPWWWQPFANPAFALAMTVVLPMAVAALLGALVFRRRVKGAYFAILSQALAAALAIWLVGQQATTGGTNGLTDFQGFFGYDLNDPVNQRMVYVIIAVALLLLMAAARQLFVSRYGELLIAVRDSEERVRFLGYNPANVKLVAYVVAAGMAGLAGALFVPAVGIISPALIGIVPSIGFVIGAAVGGRASLVGAVLGAIAVAWAQSTLSDAWPAGWTYLQGLLFVVAVGFLPGGLASLRTVLRRRRTSSDRVGATKGVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8S3</accession>
    <name>A0A7K2Z8S3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_05430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000248">
        <property type="protein sequence ID" value="MYW28723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="662" mass="70966" checksum="BA7BB7743C7E0E20" modified="2021-04-07" version="1">MQGEDRSGAGYGGGGPVDGEASPGHGHEGRPQVVIEGRYELLEPIGSGGMGEVWKAHDRRLRRFVAVKGLLDRNAMTAGTQAAAMQRARREAEAIAKIEHPNVVTVHDQVETDNQVWIVMKLLEARSLADLLRSERVLAIPRAADIGLQILQGLRAVHAASVVHRDVKPGNVLVREDGTAILVDFGIATFEGAAQVTRSGSVIGTPPYLAPELFTPGSPGPAPASDLWALGITLYEMVEGRVPFAGGEVWEVQENIRQSPDPSLRYAGPLAPVIQGLLFPDPHERLDAATAEAMLREVLGAPLVPNATASDTATHPPTAVSEATPDPAPEPLGPPTPAPRTPHGRRRRPWLKAATVTLCVTLLGTAGWLVAQGIGDDRADTSGGATAGSSGRGKGSTPMEKWKAANPLLKIGVKDDQPGLSKYDRKTKTYAGYDIDLAYAIAGHLGYDRDEVAFTTVPTDYRSTALRTKGVDLVIASYSITPERKSASPGGDSVDFAGPYYEASRSFLVRQKSSKYTINDSSDLRRLGVEVCTARDSTYERELPKRGFTMTESQPNTYQDCLDQLLDVTSDVYAVASDDIILAGYEKANPGKVRRLENIQGAEGYGVAMRPGSTGLKTEVCSALRKILGGEVWEDMYEKNLSALMDNDTPPGRPDLTECEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8S6</accession>
    <name>A0A7K2Z8S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="102"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="284" mass="31990" checksum="7A8228A658F6E64E" modified="2021-04-07" version="1">MADEDVSEPDLDLDIDPADDSSAVMAAVGRQIRLWRETAGLRAAELGTAIGYSEDLVYKVEGGRRIPKPEFLDGTDRAVGAGGKISAMKQDVAEARYPKKVKDLAKLEREAVELGAYDNHNINGLLQTADYARALYEMRRPAFGPDEVERYVGARMARQEIFRRKPLTMLTFIQEEVTIRRPLGGRAVLRRQLEYLLEIGELRNVEIQVMPTDREDHAGMGGQMQLLKFKDGSAVGQWESQLFSRLTFDPKEIRILEQRLGLVRAQGLTPRESRTFIEKVLGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8U9</accession>
    <name>A0A7K2Z8U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000250">
        <property type="protein sequence ID" value="MYW28748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="112" mass="12181" checksum="EF0DCE226FC5D5A1" modified="2021-04-07" version="1" fragment="single">MARPRKPLLSRDRIVEAASALVDAEGLDAVSTRRLAAVLGVSGPSLYNHFRNKDEILDAVADAVSVQVDLSMFEASDARDWREALHDWALSYRAALAAHPHIVPVLARGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Y5</accession>
    <name>A0A7K2Z8Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRC-barrel domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000258">
        <property type="protein sequence ID" value="MYW28820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026242248.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000258.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13757" checksum="3BE9A32C00E8188C" modified="2021-04-07" version="1">MQTDIDPRRLIGRKAFDRKGAKIGTVDEVYLDDATGVPEWAAVRTGLFSRDAFVPLEPSEFVEDELRVPFDRTLIKGAPDFGVGRHLSPEQELQLYRHYGLDSPPAAETGPDRDFGRLAGQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z931</accession>
    <name>A0A7K2Z931_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000256">
        <property type="protein sequence ID" value="MYW28805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029554907" evidence="2">
        <location>
            <begin position="28"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="420" mass="44134" checksum="8EFA4564DD74B56A" modified="2021-04-07" version="1">MKYRLLAGGSGLVLAAALSACSSPSDSASGDGRTTVDVWLMRDSVSDTFQKEFTADFVKRHPKIDVKIQIQEWDGIGQKITAALASNDAPDVIEAGNTQVAQFAESGGLLDLSDRKDELNGADWLSGLAEPGAYEGKQYGIPYYAANRVVIYRTDLFEKAGIDAKAIKTRDQWIDATTQLNQGSTQGIYLPGQMWYALAGFIWDEGGDLATESGGKWSGALDTPEALRGMAFYEKLQALGKGPKDSDEDDPPQAELMAQGKVAQLISTPGGANVIVEKNPELKGKLAFFPIPGKTADTPGSVFTGGSDLVVPAASAHPDEAVTFIKELTGDAWQKRLAVAMSYVPNRTSLASAVADDPGAAAMAVGAAEGHATPNTPGWAAVEAENPIKDYMTAVLTGGDPGKEAAKASQDITRAMNAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9B0</accession>
    <name>A0A7K2Z9B0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="15" type="ORF">GT040_06475</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000298">
        <property type="protein sequence ID" value="MYW28927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5029987365" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029987364" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW28927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="14843" checksum="5C5CFA6DD9CD9B6C" modified="2021-04-07" version="1">MLRTLFKSKIHRATVTQADLHYVGSVTIDADLMDAADLLPGELVHIVDIDNGARLETYVIEGERGSGVIGINGAAAHLVHPGDLVILISYAQVEDVEARAFTPKVVHVDADNRIVALGTDASAPVPGTRTERSPQAVVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9C7</accession>
    <name>A0A7K2Z9C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000300">
        <property type="protein sequence ID" value="MYW28943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="17208" checksum="3B675B20500A8CBE" modified="2021-04-07" version="1">MEEGTSKSPSNCGHTGVEQDFDISNWDVREGCEVRQILDRVADKWSLLAIAHLERRTLRFSELRRLIDGISQRMLTVTLRQLERDGLVRRTVYPVVPPRVEYELTPMGATLHTTIRSLVDWTEGHQQEIARARAEYDSRQSEEEAGAATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9F4</accession>
    <name>A0A7K2Z9F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_06310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000295">
        <property type="protein sequence ID" value="MYW28895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020803">
        <property type="entry name" value="PKS_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00828">
        <property type="entry name" value="PKS_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_MT" evidence="4">
        <location>
            <begin position="156"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="434" mass="48224" checksum="8D993AAC2AB103C9" modified="2021-04-07" version="1">MARAASRLTALAEELLSEPLPVRVRAWDGSESGPPGAPVLVIRHRRALRRLLWKPGELGLARAWVAGEIDVEGDLYEVLDRIAGLLWDRGADAKDAVHPARDPAVRAFARGLLQLAGPWPPPAPPAEEVRRRTGPLHTKRRDKEAISHHYDVGNDFYALVLGPSMVYSCAYWQDGGSLEDAQRDKLDLVCRKLALKEGDRLLDVGCGWGSMAIHAAREYGAHVTGITLSQEQAAHARKRIAEAGLTDRIEIRVQDYRDVTDGPYDAISSIGMAEHVGSVRYREYADDLFALLKPGGRLLNHQIARRPEKDEDAYRIDAFIDSYVFPDGELAPLGRTLATLEEAGFEARDVEAIREHYALTLRQWVANLERHWEQAVRATSPGRARVWRLYMAASALSFEHNKIGVNQILAVRPLEGGSSRLPLRSRAWTEEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9H3</accession>
    <name>A0A7K2Z9H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1080 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_06835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000306">
        <property type="protein sequence ID" value="MYW28997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029442148" evidence="1">
        <location>
            <begin position="46"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="55"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="2">
        <location>
            <begin position="687"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1010" mass="109532" checksum="8F34D93727F4B8F5" modified="2021-04-07" version="1">MHPRPFHRSRRRPVLRHRPFLRRHLTGLLVSSFLVGAFSAVPATAAPAAPAELPPQEPGVTLRVFDVQVPLDELCDIKAGQTPNVDKLMPQIDWDAADDFGFEDRFVSQVTGNIKVPEDGSYTFRLTSDDGSRLLIDDRLVIDHDGLHGADPKDGAVTLTAGYHSLRIDHFDRTGGQQITLAWQPPGSGDFAVVPNSVLSTDADVVRVTAPGRKECEGALDSPGDGLPLTETHPDYALTDLRPAGFEPQVSAMDWLPDGRLAVTTWGGTDNETGEVYLLDDVQGETGPDRVKAKKVAEGLKEPMGIKAVDGKLYVSQKHELTELTDTDGDDVIDERRTVATWPYGGNFHEFAFGLLYRDGFFYLNLSVAIDYGGATTNPQPAQNRGTTIKVNKETGKVDYIAGGLRTPNGIGWGPENDLFVLDNQGGWLPSSKLVHVKQDRFFNHYTNPSGPFDAKPVTKPVLWLPQNEIANSPSTPLQLTEGRFAGQMLFGDVTYGGIQRAYLEKVDGEYQGAVFRFTQGLEAGVNRISMGPDGAIYAGGLGAGGNWGQEGKLTYGLQKLSPSGDKAFDILAMRAKPGGFELEYTEPLSEETAAKLAESYQVEQWTYAPTPAYGGPKIDEETLKVGSATLSEDGKKVTLALPGLKPNRVVHVRSPRPFSSASGTELWSTEAWYTLNSLPGDQPSPTLYEAEEAALTGGAGVDTEHAGYSGGGFVDNFGNQGAAVTFDVRTEKAGTYDVGLRYSNGPDPAPGTKTISVHVNGTKVRQTSLASTTDWKTWATKNEQLELDEGRNTITYSYDSGDTGHVNLDMIAVHPKGARIPLFDGTSQAAWQHPDGRTPEWPVSDGEMEIKNGDLRTKQGFEDFRVHVEFWLPNLPPDVTGQDRANSGVYLQERYEVQILDSYGDDTLADNEAGAIYTKKAPDVNAATAPETWQTYDITFRAARFDSSGNKTEDARISVVWNGVTVHDDVAVDGPTGGGAAEAATAGAIKLQDHGSKIKYRNVWVEPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9R2</accession>
    <name>A0A7K2Z9R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000325">
        <property type="protein sequence ID" value="MYW29074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="306" mass="30672" checksum="80C839CD8F809C90" modified="2021-04-07" version="1" fragment="single">MSRARGPGAGPGRGWLLRLVIAFAFAQGAVSMARPAVSYRALALGADETAVGVIAGVYALLPLFAAVPLGRRTDHGRCAPLLPIGVVLISGGCALSGVVSSLPAMAAWSGVMGLGHLCFVIGAQSIVARQSAPAEQDRNFGHFTIGASLGQLGGPIAAGALISGESGALGRTSALALLVSAGVCAVALTSLWRIEHRRTPGAGPGAHTAGAKVPVTRILGARGVPAGIFISMAVLSSTDILTAYLPVVGEHRGIAPATVGLLLSLRAAATIACRLVMTPMLRLLGRTALLTTSCLLAGLLCAGMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9T9</accession>
    <name>A0A7K2Z9T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000354">
        <property type="protein sequence ID" value="MYW29126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="21639" checksum="B25C686601BDB98D" modified="2021-04-07" version="1" fragment="single">MAVIGAGPAGLAAAVTAADSGLRVVLIDASERPGGQFFRRAAPGLAPRNKLVHHKRATFAALSARLAAHVHGGGITYLPRHHVWTAEGDGSPAAGPTRWTLRHVPVDGAPAAPTPSDGIRVTTARFLLLATGAYERQLPFPGWTLPGVVAAGGAQAILKDSGALPGRRIVVAGSGPLLPAVAVSLAEAGADIPVLAEAASYTGYASRPGVLARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9X7</accession>
    <name>A0A7K2Z9X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="409" mass="44558" checksum="15E13D274E80FD76" modified="2021-04-07" version="1">MTRIALDPFVRDLDGESAALRAAGPLAEVELPGGVHVYAVTRHAEARALLTDSRVVKDINVWGAWQRGEIPMDWPLIGLANPGRSMLTVDGADHRRLRTLVAQALTVKRVERLRAGIEALTNASLEKLAALPAGQPVDLKAEFAYPLPMNVISELMGVDAADHPRLKELFEKFFSTQTPPEEVPQMMADLGTLFTKIVDDKRANPGDDLTSALIAASEDGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKVLNGEIGWDGVIEETLRWNTPTSHVLIRFATEDIEVGDQILPKGEGLIISFGALGRDEEQYGPTAGDFDAARTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELELAVPAAELRNKPIVTQNDLYELPVELGCPFGHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAC2</accession>
    <name>A0A7K2ZAC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000385">
        <property type="protein sequence ID" value="MYW29296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="19677" checksum="2ADB2BDAC6E91598" modified="2021-04-07" version="1">MPLRDDDAGKPDLALGQTHHLLDDDGEGLARDLVRSAKLTLRRDGGHFHPMTNGNWTDATYEAVLTLDRALAPEFTTAMAKAIRQRLKAVFKQLERDDAQSPVIEAALRPLPEITQDWRHRGDDPTKQAGHERQSNQGYPAANGPTFASRAELAVYQILQDLRQWALRRFRRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAU8</accession>
    <name>A0A7K2ZAU8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmF</name>
        <name evidence="5" type="ORF">GT040_09205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000418">
        <property type="protein sequence ID" value="MYW29448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003965982.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000418.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZAU8"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="57" mass="6596" checksum="ACE34327DBB23DCD" modified="2021-04-07" version="1">MAVPKRKMSRSNTRHRRSQWKAAVPTLVSCERCQEPKLQHIACPSCGTYNKRQVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAW2</accession>
    <name>A0A7K2ZAW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000425">
        <property type="protein sequence ID" value="MYW29490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="305"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="442" mass="47537" checksum="8243B3B93298A946" modified="2021-04-07" version="1">MPVRRRTTALPARLTALRTPADPGFWRSPVRGARFTAVLGMVLLAGLTLLFVTGLLSYAAYNPDLDPVNDKTPGKGWLGFYLFAWPTGPHWLYRLTQGLHVTVGIVLVPVLLAKLWSVVPRLFALPPARSVGHALERLSVLLLVGGALFQFITGLLNIQLDYLFPGSFYTLHFYGAWVFLAGFVTHVALKLPQAVRVLRSGGIRRGETSPLAASDPLTAPETLAAPDTLAAPDPLPATLSRRGALVMVGAGSLLLLITSAGRSFDGPLRRIALLTPRGGTDQGPGPNAFQVNKTAAAVRITPADTGERWRLTVRGPAGELRFSRAELLAMEQHTAALPIACVEGWSTSDQLWRGVRLSDLAALAGYPDNPPDVFVESLQRSGSFRKAALRDNQVRDGRSLLALEVNGAPLSPDHGYPARIIVPAAPGVLNTKWVETLTFGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB16</accession>
    <name>A0A7K2ZB16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_09720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000451">
        <property type="protein sequence ID" value="MYW29546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="30748" checksum="F24BCC5C4F736C80" modified="2021-04-07" version="1">MSETALAKRPAEVAGVARRAGPTAGERLTRAAERSWRPVALLVACFALWWVIAAAELVEPYLVPSPGATLDVLTGKAGYLWQHSWVTTYETLLGFVIAVAVGVFAAVVMVYSSTVERTLYPILLFAQVVPKIAIAPLFVVWLGFGIAPKILIAVLIAFFPVVISMVTGLKAVDPEMLQLSATMGAKPWQTFLKIRFPASLPHLFSGLKVAVTLAVTGAVVGEFVGANEGLGYVILQANGNLDTPMLFAGLLVMSLIGVVLFVVVEIAEKLLLPWHASRRETSATTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBT2</accession>
    <name>A0A7K2ZBT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000505">
        <property type="protein sequence ID" value="MYW29830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7079" checksum="D107255A5FF9F866" modified="2021-04-07" version="1">MSTHIGMDSGVSVICRPADFKGSGGATIRVCVDGSCEERASGRGGGVVTDTAQAQLTENRPNGPNCEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBT3</accession>
    <name>A0A7K2ZBT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="13098" checksum="0B4BCA554C21D9D5" modified="2021-04-07" version="1">VAAGSGALRDTANPVGRGDPLEAAYLLASQHGLRAEHAYAAVSTTARAALGLPDVRVEAGFPAELLAVRGEQLSAALSLAYSRIVIHRGRIVARTSAVREYCDSDPDPTAGPDLPRQGRPDSGGGPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBZ3</accession>
    <name>A0A7K2ZBZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">whiG</name>
        <name evidence="9" type="ORF">GT040_11340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000513">
        <property type="protein sequence ID" value="MYW29859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241016.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000513.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="278" mass="30761" checksum="EE11B640EDF0DA22" modified="2021-04-07" version="1">MPQHTSGSDRAAVPPVARGTVRPPAPSSLDELWRSYKTTGDERLREQLILHYSPLVKYVAGRVSVGLPSNVEQADFVSSGVFGLIDAIEKFDIERAIKFETYAITRIRGAMIDELRALDWIPRSVRQKARNVERAYATLEAQLRRTPSESEVASEMGIALEELHAVFSQLSLANVVALEELLHVGGEGGDRLSLMDTLEDTAADNPVEVAEDRELRRLLARAINTLPDREKTVVTLYYYEGLTLAEIGNVLGVTESRVSQIHTKSVLQLRAKLADAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC14</accession>
    <name>A0A7K2ZC14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan DD-metalloendopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000528">
        <property type="protein sequence ID" value="MYW29896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="30899" checksum="1D3E72ADD3B89F39" modified="2021-04-07" version="1">AYTVATGDSLSGIADAQRVRGGWQRLYAANRTVVGDNPDLIFPGQRLSLVPRGGDGASARKPAPPPEPQKRQAAPQPRSSEQQAARSRADEAKKAEQRKAEEKRAEQQKAEQQKAEQERAEQKRAEQERAERKKAEQKQAAPKPQKQAPAERAVKRSGMSAPVAASTGTAYRQAGSWSSGYHTGVDFPVPTGTSVKAVAPGRVVSSGWAGAYGYEVVIRHEDGRYSQYAHLSALHVKEGQSVSGGQRIARSGSTGNSTGPHLHFEVRLGPGYGSDIDPLAYLRAGGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC60</accession>
    <name>A0A7K2ZC60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000546">
        <property type="protein sequence ID" value="MYW29946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="302" mass="32809" checksum="F802555C0801B9B7" modified="2021-04-07" version="1">MRNRVRAADGRHLMVERLGDPRGRPVFLLHGTPGSRLGPAPRGMVLYQRRTQLITYDRPGYGGSDRQEGRRVSDVVEDVRAIADSLGLERFAVVGRSGGAPHALACAALLPERVTRTAALVTLAPWGAAGLDWFDGMAASNVLAYSTAAADPDSLAESFIVRSAQIRRDPVRLLDDLRRELTDSDRMVVNDAGIRSMLLRNYSEGLRTSAYGWIDDAIAFCSPWGFDPAHITGRVLLWHGVKDVFSPVGHSRWLAGQIPGATAVLEPAAAHFDALAVLPRILNWLLDEREPPGDPLPATTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCJ8</accession>
    <name>A0A7K2ZCJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6 12">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hemG</name>
        <name evidence="14" type="ORF">GT040_12535</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:43437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6 12"/>
    <dbReference type="EMBL" id="WWKE01000596">
        <property type="protein sequence ID" value="MYW30087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="8 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW30087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="387" mass="40290" checksum="9322F02F0B6C2145" modified="2021-04-07" version="1">MGVPGDPAALDGVLSPEGLARIAEERELTPTPVGDDVAVGAYVADRLGREVVDRLVEPLLGGVYAGDAYRISMRAAVPQLFEAVKEGGPLLEAVRRIQQRAAARQQTGPVFQGIEGGIGTLPDAVADAVRAGGGRILTETPVLGLTRTDAGWAVRTDTGVITADGIVLATPAWSASALLAAESPAASAELTGVEYASMALVTLAFRRTDVEAYEALRGRSGFLVPPVDGHTIKASTFSSNKWQWVADAAPGLFVLRTSVGRYGEEDHLHREDGELVAVSLRDLRAATGLAARPVDSEVTRWIGGLPQYPVGHHTRVARIRDEVAKLPALRVCGAVYDGVGIPACIASAQRAADEIAGEITGEDTGKIAGEIIATPTLVQGTGSEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCM9</accession>
    <name>A0A7K2ZCM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Excalibur domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000560">
        <property type="protein sequence ID" value="MYW30025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008613">
        <property type="entry name" value="Excalibur_Ca-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05901">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00894">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Excalibur" evidence="2">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="17644" checksum="55FD2ABD91E0E6A7" modified="2021-04-07" version="1">MNWNDPQHPSRQADWGPGATVPPPDPSTGPRWARKRVILPAAGVLFLLGIGIGATGEEPEAVQTAAVKAEPGPTVTVTVTETAKVTVTASPEPAPTVTKIKKVRVTVTAPPPEPAAEAPDPVYDEDDDSGGGSTYYKNCTAVRAAGAAPIRRGDPGYASHLDRDGDGVGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCY5</accession>
    <name>A0A7K2ZCY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000602">
        <property type="protein sequence ID" value="MYW30168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="212"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="30528" checksum="725696049E516FE3" modified="2021-04-07" version="1">MELQTGSEKAGDDTALRWRALNPQIAAAGLASAESRLRRKVADLSGSRRNLDELSRVYSILSTAHRSGDAIEVFASPAEAALLIDEAMARCRSEVISAQPGEGGPAEEVRPATARDVELLGRGVRLRFLYRESSLHHPSTRSHVSRVTAAGAHVRTSAELFGRLMVVDRSVAFVPHHRVAGGAAVVRDRSVVTLLREAFDHAWGRAHAVEDGRTKPAELSDLHRTILRLLSEGARDETIARRLGVSLRTCRKYVAEIFEAIGAESRFQAGYLAAQRGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD20</accession>
    <name>A0A7K2ZD20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000611">
        <property type="protein sequence ID" value="MYW30222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="25975" checksum="A7A154AAACCCF399" modified="2021-04-07" version="1">MSSETGSTGSTPEPAPVDPAPAEPVQYDDGYGQAIGVGPHPLPWPEGERYDPELLAHGDRRNVGDGYRYWTREAIVADLDLRRHAFHVAVENWGHDFNIGSVVRTANAFLAKEIHIVGRRRWNRRGAMVTDRYQHVRHHPDTADLTAWAAAEGLPIIGIDNLPGAVPLERTELPRRCVLLFGQEGPGLTEEARKHASMVCSIAQFGSTRSINAGAAAAIAMHAWVQRYADVPDPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD47</accession>
    <name>A0A7K2ZD47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_13380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000621">
        <property type="protein sequence ID" value="MYW30252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="7113" checksum="6DDA558E4865BFB2" modified="2021-04-07" version="1" fragment="single">MSKEAEFDAFYAATAKRLVATVYAMTGDLAESEDAVQEAYARAWQRWDRLTREGDPLPWVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDE8</accession>
    <name>A0A7K2ZDE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">hemE</name>
        <name evidence="14" type="ORF">GT040_14070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="WWKE01000661">
        <property type="protein sequence ID" value="MYW30383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="13">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW30383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="361" mass="38725" checksum="DE2E0FD66736E820" modified="2021-04-07" version="1">MSANTSPTGQQTTTAASNDATQDSAFLKACRREPVPHTPVWFMRQAGRSLPEYLKVREGIAMLDSCMMPELVTEITLQPVRRHKVDAAIYFSDIVVPLKAIGIDLDIKPGVGPVIAEPVRTRADLARLRDLTPEDVPYVTEAIGMLTAELGATPLIGFAGAPFTLASYLVEGGPSRNHERTKAMMYGDPQLWADLVDRLAEITGAFLKVQIEAGASAVQLFDSWVGALAPADYRRAVLPASAKVFEAVAPYGVPRIHFGVGTGELLGLMGEAGADVVGVDWRVPLDEAARRVGPGKALQGNLDPAVLFAPTPAVEEKTREVLDAAAGLEGHIFNLGHGVMPSMDPDALTRLVEYVHEQTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE21</accession>
    <name>A0A7K2ZE21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000716">
        <property type="protein sequence ID" value="MYW30572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19160" checksum="1B1544E17583431F" modified="2021-04-07" version="1">MEQSIDSNKKPEFAAGTDPAFIPLPGLAAPVAPRKTEPESEAAPETDPELDEAPEAAAEAPEAEADAVADAVPDAEGEAEGAEDGPVFEISDRRGSIRVAREGVRFTLDDQEADFDWSEIGAVEMNPARFGRRFTVTVHLSSRRWFNAEVEAESRARLKEWPAELDAVLDAYFEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE96</accession>
    <name>A0A7K2ZE96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">pdxH</name>
        <name evidence="10" type="ORF">GT040_15455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000723">
        <property type="protein sequence ID" value="MYW30639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="8">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="9">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="5"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 6">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="56"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="24052" checksum="E25AAC8AACA1745E" modified="2021-04-07" version="1">MREQYRSEDFTESDLSPDPMDQFARWFRQVAVGGVLHEPNAMVVSTATPDGRPSSRTVLLKQYDDRGFVFFTNYGSRKGRELAANPYVSLLFPWHPMARQVIVTGTASRVSREETVGYFRTRPHGSQLGAWASDQSTVIGSREELIERYEELAARYPEGEKVPAPPDWGGFRVVPETIEFWQGHGNRLHDRLRYVREDGSGSWRVERLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEB4</accession>
    <name>A0A7K2ZEB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000721">
        <property type="protein sequence ID" value="MYW30625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="546" mass="56193" checksum="923FA85B77E6D5C3" modified="2021-04-07" version="1">MSVLDAPVTAAAPAARTTGLTPIFVRLKLTLLRNGLRQSSGRKAAYIASLVFTLLLAAGQVLGLVLLRGNAQAGTVVVLLTAVVALGWAVLPLFFPSGDDTLDPTRLVMLPLRPEPLVRALLVSSMIGIGPLFTLCLAVGSVLALAHGPAGVLVAVVAVPLTLLLCVALSRAVATANVRLLNSRKGRDLAVLSGLVIAVGIQFVNFGAQRLGEAGGLSTLEPAGNVARWLPGASAIAAVDAASDGAYGVAVLQLLITVAALVALVWLWQRGLVKLMTAPDGSTLAAAAEPTRKESGRTGLSALLPEGRTATVVHRSLLYIARDPKTKAAWVTALAIGAIVPLINALQGTGSIYFACFAAGMLGMQMYNQFGQDTSAFWMVALTISSTRDAYVELRARALALLLITLPYTVLVCVATAALLGSWQALPGVLGISFALLGAMLAIGAVASAQFPYSIPQEGAFKNVAPGQGGLAWISILGGMLAAPVLAGPVIALTVWLHIADRQDALWLVIPAGAVFGALIGWAGLRIAAPRTANRLPEILTAVSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEQ9</accession>
    <name>A0A7K2ZEQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000764">
        <property type="protein sequence ID" value="MYW30812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="491" mass="53782" checksum="A501D1050C241D75" modified="2021-04-07" version="1">MSGSGAGDTEAGKRPNAQLGSWFVRSGWSKGELARQVNRRARQMGAHHISTDTSRVRRWLDGEQPREPIPRILSELFSERFGAVVAVEDLGLRTAHQSPSVAGVDLPWAGPQTVALLSEFSRSDLMLARRGFLGSSLALAAGPALIEPMQRWLVPVPAKGPGEPESEASARRPSRLSGPELDLLESTTAMFRQWDAQCGGGLRRKAVVGQLHEVTDLLQEPQPGPTSKRLFRCAAELAELAGWMSYDVGLQPTAQKYFVLALHAAKEAGDKPLGSYVLSSMSRQMIHLGRPDDALELIHLAQYGSRDCATPRTQAMLYAMEARAYANMGQPSKCKRAVRMAEDTFLDAGLDGEPEPDWIRFFSEAELNGENAHSYRDLAYVAGRSPTYASLAEPVMEKAVELFGEDDEHQRSYALNLIGMATVHLLQREPEQSTVLAGQALKIAKKVRSERVNTRLRKTVDTAARDFGDVADVARLTDLLSEQLPESAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZER3</accession>
    <name>A0A7K2ZER3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000766">
        <property type="protein sequence ID" value="MYW30826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="19295" checksum="7714AF50EEF80BF6" modified="2021-04-07" version="1">MNICVFLSAADLDDRYTVPAREFAELLGRGGHTLVWGGSDRGLMKVVADGVQTAGGRLVGVSVEFLAASARTNADEMVIARDLAERKALLLEKSDAIVIMVGGTGTLDEATEILELKKHGRHTKPVVLLNTAGFYDGLREQFQRMEDEGFLPLPLTELVFFAKDGVGALAYLEESAGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFH8</accession>
    <name>A0A7K2ZFH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_18040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000856">
        <property type="protein sequence ID" value="MYW31124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="405" mass="42165" checksum="BA5AB73CFEF32E66" modified="2021-04-07" version="1">MIAAVAGAAIVTAGAFTTVPGLLVTPLGEEFAWNRGQVALAASVNMVLFGLTAPFAAALMDRVGARRVAGGALLLVSAGGVLTAFMTRPWQLVAYWGVLIGLGSGCLTMTFAAGVTARWFDRRRGLVTGALSSSSHLGQLLFLPLLAGSVERHGWRPPVVTLALVALAVAALVFLALRDHPADVGVRPYGAREFVPEPPPPSGTATRTLKVLAGALRTRPFWLLAGMFVLCGASTNGIMWSNWAPAAHDHGMRVTAAASLLSLIGVFSALGALLSGWLTDRFDPRRLLTVCFALRALTLLALPALFSSAVTAPMLLFVFVYGLVDVATVPPVIELCRRVYGTDGPIVFGWANAAHQLGAGASAFLGATARDVFGTYDVVWVALSAGCLVAAVLAPAVRATLVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFQ2</accession>
    <name>A0A7K2ZFQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000856">
        <property type="protein sequence ID" value="MYW31129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514287.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000856.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8485" checksum="6E41C0BE64F41113" modified="2021-04-07" version="1">MHHVYNGMAATELRGVVWQKSRHSNSQGSCVEFAKLPGGDVAMRNSRHPDGPALVYTPAEIEALLLGVKDGEFDHLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGA3</accession>
    <name>A0A7K2ZGA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000895">
        <property type="protein sequence ID" value="MYW31329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7862" checksum="0126A2E7B2A6CCA4" modified="2021-04-07" version="1">MPRNSSRPERGAEDTAPPQHHGLFLEPHFAAGLTSPDEDDEELDAAYDALPAPTTSAREPERANRRQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH52</accession>
    <name>A0A7K2ZH52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_20825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000979">
        <property type="protein sequence ID" value="MYW31655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="362" mass="39241" checksum="79DE439D261CC293" modified="2021-04-07" version="1">MNQNPALNQKPPSNQKPPSNRKKTPFVSVVIPNYNYGRALELCLRAALAQTYAPMEVLLIDDCSTDDSVAVAEACGVRVISTGVNSGVATTRNTGAAHARGEIVVFVDSDVAMEPDAVANAVALLSSDPKIGAVCGTYDAEPLIRDSLIEEYRCLHQYYWLAETEGRIGTLHTAICAMPADVFAEIGPFNPRLRHTEDGDYAARICRSYEVHSSTTVRGRHDHDDTWRVVLRKVFHRTRLHIPLYVRRGDLPGGIATGPRAGASVAALLAVLTLPLGFAAAPWLLLPAGLLAFALLADTALYRFVLRRRGPLFTAYFAFVHSVVNAVIAAGAGVGVLQWLASRRFRGLYEPGEHLTAVRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH65</accession>
    <name>A0A7K2ZH65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_21080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000994">
        <property type="protein sequence ID" value="MYW31703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="117"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="305" mass="31471" checksum="D3EFAD747C68F60D" modified="2021-04-07" version="1" fragment="single">SQPVAKLRWLARTEPENAQRVAAVMQPHDWLVWQLLGRPARRTTDRGAASGTGYWSAGSAAYRPDLVELALGHPAALPEVLGPADSAGTTPEGLLISAGTGETMAAAFGLGVAVGDAVVSLGASGSVMAVHHEALADPHGMITSFADATGMHLPVVHVSNAVRALRGTTEMLGLDGLEELSALALKSTPGASGLVLLPYLEGERTPQLPHTAGTLSGLRRESMKPEHLARAAFEGMLCSLADALDVLRGRGVEVRRVFLLGAAAELPAVQALAPAVFCTQVVVPEPAQYAALGAARQAAWALGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH68</accession>
    <name>A0A7K2ZH68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF456 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000985">
        <property type="protein sequence ID" value="MYW31687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007403">
        <property type="entry name" value="DUF456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04306">
        <property type="entry name" value="DUF456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="16528" checksum="FF6726F1C04D1F08" modified="2021-04-07" version="1">MGVWQLVGVGLVMLLGLVGVLVPGVPGQAIVWAAVLWWALTDMTPTAWGVLIGATALMLLNQALKPLLPPRRPGESGAPRRTVMIGGVAGIVGFFVVPVVGGIAGFVGAIYGAERLRLGSRGAGWTSVRSVMRATGYAVLVELFACLLVAAAWLGALIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH93</accession>
    <name>A0A7K2ZH93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_21100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000996">
        <property type="protein sequence ID" value="MYW31707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="24841" checksum="B5D5AD4B04747F7C" modified="2021-04-07" version="1" fragment="single">RALGSMLAEALEAVHGAGLVHRDVKPGNVLLGLDGPRLIDFGIARALDDTVLTATDAIVGSPGFLSPEQAQGRRIGPPSDIFSLGCVLVYAATGGRPFGSGPVEAMLFRTVHDPADLGALPPGLRPVVEGCLSKEPEGRPTSGDIRRAFAEDASGGSWLPGPVTHLIAERSARMLALPDIEATSLDAGSTVETDAGSRDTTAVPVSPGRRRFLAYVTGGAVLAAAGGTTAWLATAFGDEKDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHB0</accession>
    <name>A0A7K2ZHB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_21290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001013">
        <property type="protein sequence ID" value="MYW31742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="13"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="440" mass="48093" checksum="9EF97458081136D8" modified="2021-04-07" version="1">MVTSSKRRMPDRRTYVLDTSVLLADPGAMARFDEHEVVLPIVVVTELEAKRHHPELGYFARQALRLLDDFRIRYGRLDAPIPLGDLGGTLRVELNHSDPGVLPAGYRLGDNDSRILAVARNLQAEGYDVTVVSKDLPLRIKASSVGLLAEEYRAELAITDSGWTGMTELALSGEQVDLLFTEETLYVPEAAELPVHTGLVLQSERGKALGRVTAEGNVRLVRGDREAFGIHGRSAEQRIALDLLLDQDVGIVSLGGRAGTGKSALALCAGLEAVLERQQHKKVMVFRPLYAVGGQELGYLPGSEAEKMSPWAQAVFDTLSAVAGREVIEEVLGRGMLEVLPLTHIRGRSLHDAFVIVDEAQSLERNVLLTVLSRIGANSRVVLTHDVAQRDNLRVGRYDGVVAVVEKLKGHPLFAHVTLTRSERSQIAALVTEMLEEGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHH2</accession>
    <name>A0A7K2ZHH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001020">
        <property type="protein sequence ID" value="MYW31813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12231" checksum="81F073166A69FA02" modified="2021-04-07" version="1">MDVLINVFVALHIIGIASLLGGFLTQMKAMGAGTARFVPAMLHGALTMLVTGVALVGLNQADDQAVNNIKIGVKLALLVVILALVYVKRDEEKVEKGAFAAVGGLTVANIFIATLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHH8</accession>
    <name>A0A7K2ZHH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001019">
        <property type="protein sequence ID" value="MYW31806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="13504" checksum="4F59935882FE8D28" modified="2021-04-07" version="1">MTEKPAAEKIVLDPDSGIAPYEQLRTQLSERARSGVLPVGHRLPTVRGFAEELGLAANTVAKAYRALEADGVIETRGRNGTFVAAAGGAAEQKAATAAQLFAETAERLGLTRQQALALAKDAVRAAYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI95</accession>
    <name>A0A7K2ZI95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3499 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001077">
        <property type="protein sequence ID" value="MYW32076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="12062" checksum="2E54E14ABA4BB472" modified="2021-04-07" version="1" fragment="single">MVSPVRRCSRTACGRPAVATLTYVYADSTAVLGPLATYAEPHCYDLCAEHSERLTAPRGWEVVRLSDGSAPAHPSGDDLEALANAVREAARPHDRGPDGVGRGPRAADPVEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIE5</accession>
    <name>A0A7K2ZIE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001091">
        <property type="protein sequence ID" value="MYW32108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="73" mass="8149" checksum="61B0365B52A3B228" modified="2021-04-07" version="1">MPRPSGFQYEQHGDRSVTVAHHGRPAGTLRGGRAEKFLAEVAAGDAQLVMARWTGAYKHGNERTARDHPRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIG2</accession>
    <name>A0A7K2ZIG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3631 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022081">
        <property type="entry name" value="DUF3631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12307">
        <property type="entry name" value="DUF3631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3631" evidence="2">
        <location>
            <begin position="213"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="409" mass="44457" checksum="F7A301AC6A6B4FFA" modified="2021-04-07" version="1">MDDPAPSTPSLPAGAAAWPPVAVPGRPRPDEDGPSSEQHHLASASEGEEALTALREQILRYVVMPSEEASVAVTLWVAATHLQTAWQHAPRLAVVGPAKRCGKSRLLDVITESVHDPLITVNASAAAVFRSITDTPPTLLVDEADTLFGSAKVAEKNEEMRGLLNAGHQRNRPTLRVSGPNHEVSKFPTFAMAALAGIGDLPDTIMDRSVVIRMRRRMPGEKVAEFRTFRDTPPLHALRERLATWLGPLHASAMELTPAMPVEDRAADTWQPLVAVADLAGGMWPSLARNACRVMAKHEAEQDQDRSSLGIRLLADVRRAFASEGNPPALRTSRLLDILNQDAETPWPEYTANGLTPRGLQILLNEYGISSAPKRFHGNVQARGYTRRHFADAWARYCPEPAPEAATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIT8</accession>
    <name>A0A7K2ZIT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper resistance protein CopD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_24050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001121">
        <property type="protein sequence ID" value="MYW32258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="8">
        <location>
            <begin position="279"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="385" mass="38564" checksum="75EB2FF1483DB19B" modified="2021-04-07" version="1">MIFSGPPADPAAPTPPTGSGTSAASSGTPPTGSGTLSSGSGTPPTGPGLPSATGAGLPSTGPGTTATPPGLPPAGAPADAATIALAAAGLLALLIALAGPGLAARGTGELRIPGAGLTTLLRTVLFTALAVHLGELLAPQLIRPLRSRPRTAARSWSLYAALAGAAAAAGQIGQLAAVSGLGITETYATRDGGLLLLIANGLVLAAFCAASKRPALALAPLAVVIGAEAIRAHPEAYSPEIGAALTVIHLTAASLWTGGLLYVLRTMWLWRGSPVAARALLGRYARLAIWLYVALAATGTVSTLRRLPLDVLLTSAYGRTLLVKMALMAVVSALAVAARRRMLRDTDPAVAHRLARREQAVLGAVVVVSAILTVVPDPHRISLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ24</accession>
    <name>A0A7K2ZJ24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001148">
        <property type="protein sequence ID" value="MYW32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029615124" evidence="1">
        <location>
            <begin position="46"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="71"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="362" mass="38470" checksum="6A4D10727B65DBF9" modified="2021-04-07" version="1">MSPSIPAGRRTGPLARVLALAIGAVLVLGGCGSGGSGKTATEAKADGASNSFPVDIKHAHGTTTIKEKPRRIVTLSWMSLDVVAALGTVPVGVDEQWGGDKDGYTPWFRTQVEKLGGPLPETLKYGDAGEIDFEQILSLEPDLIIGLYSGITDVDYKRLAEIAPTLPYLKKPWDGGTWQEMTRTIGKAMGEEKKAEGLVKDVGGQLAAVAVDHPEFKDRTFTYAVALTPGSTEVGLYLDYDARVRLLTEIGFRNTPSMSTIAATAKGTNWYGGVSLEKLDSIEADVVVAWANAPAEVTYSLKDPLFSRWKPIAGKHYAFVQDPQLAMATSGPTVLSIPWGLERYVPMLADAVAGKGSTGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ80</accession>
    <name>A0A7K2ZJ80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2083 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001160">
        <property type="protein sequence ID" value="MYW32406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018653">
        <property type="entry name" value="ScfR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09856">
        <property type="entry name" value="ScfRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="2">
        <location>
            <begin position="64"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="ScfRs" evidence="3">
        <location>
            <begin position="176"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="37122" checksum="76C568893E4D51BA" modified="2021-04-07" version="1">DLTAEKLAAEIGVRPGEVVTALAARLTERHGIRLATADDRQGRAGGASGGRRPARHGSDESSREADTGRLHHYAPDARVLYLSSRLRPGQQAFRMATQLALLEYGREISQLASEDYDEGSATWPLARIGVANYFAGALILPYRAFHTAAEEVRYDIERLTDHFGLGYETVCHRLSTLQRPRLRGVPFSFVRVDRAGNMSKRQSATGFHFSRAGGTCPLWNVYEAFAAPGRIHVQIASMPDGQRYLWTARAVTRHRGGWGEPGKTFAIGLGCEIRHACRLVYSDGLDLDNASAATPIGMGCRICERLDCPQRAVPPLGQPLAIDENSSTFVPYPVKGAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ86</accession>
    <name>A0A7K2ZJ86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001162">
        <property type="protein sequence ID" value="MYW32416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="133" mass="13986" checksum="DAAE59B8E1A9DB7F" modified="2021-04-07" version="1">HPLVRGVVGLAPWCPPGDPVTQLAGREVVLVHSSRDRITSPQATQSLTARARRAGARTCMVTVRGGDHAMIRRAPAWHRLTTTLVTGLLGTGSLPEPVTTALGLPPTAEPTEGTLDLDRLRAQRGPAGLLPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJB4</accession>
    <name>A0A7K2ZJB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gmd</name>
        <name evidence="6" type="ORF">GT040_24930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="WWKE01001164">
        <property type="protein sequence ID" value="MYW32425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514437.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001164.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="6"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="337" mass="37809" checksum="973857791A9AB90A" modified="2021-04-07" version="1">MAKTALITGVTGQDGSYLAELLLDKGYTVHGLIRRSSSFNTERIDHIYQGPEEPERSFVLHHADLTDGVALVNLLRDIQPDEVYNLGAQSHVRVSFDAPLYTGDVTGLGTIRLLEAVRASGIQTRIYQASSSEMFGASPPPQNEKTPFHPRSPYSVAKVYSYWATVNYREAYDMFAVNGILFNHESPRRGETFVTRKITRGVARIKAGLQDRLHLGNLDAVRDWGYAPEYVDAMWRMLQCDTPDDYVVATGEGVSVRQFLEFAFEHAGLDWAEHVRYDPKYERPSEVDALIGDASKAEELLGWKPEVKSRELARIMVDADIRLLSDQLTGAAVRVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJF1</accession>
    <name>A0A7K2ZJF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001177">
        <property type="protein sequence ID" value="MYW32461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="377" mass="41051" checksum="4799DBC010415022" modified="2021-04-07" version="1">AALAGRHSSGIDLGRLGRWEEAGDVHRAVAAQRESVLGPDHPDTLASRHEIGLTLSRTGRAADALREFGQVAAGRERTLGPDHPQTLAARQETAHVLGQLGRHFESHQVYAAVLAARERSMGPDHPETLRCRHHLALNLSRLGRPEESWQLARQVADDRARLLGATHPDTLATRYEVAYTLGRLGRWAEALESYQDVARARAATLGPDHPGTLAARYEAGISLGRLGRSAEALELFRALVADRTRVGGPSDAETLRARHGLGVNLGRMGHWEEAVTEAREVCAIRESTLGPDHPDTVLSRREVAVALGWLGRWAEALIAYREVAGARGRGLGPDHPETLAARHDEAHCLDRLGRKKESAELFRTLATHRAQNALPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJG7</accession>
    <name>A0A7K2ZJG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001193">
        <property type="protein sequence ID" value="MYW32485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KR" evidence="1">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="19734" checksum="364EFFA259E8449E" modified="2021-04-07" version="1" fragment="single">VHGVSHLLIVSRSGPAAPGAGALADDLARLGAKVTITACDTADRQALAALLAAIPDEHPLTGVVHTAGALDDSLIPVLSPEQLAGVLRPKVDAAWNLHELTAGHDLSAFVLFSSIAGVVGGPGQSSYAAANVFLDALAAHRADQGLAATSLAWGLWDSAQGMGGHLSAADLKRIARTGLLPVTEEDGPRLLDTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJR3</accession>
    <name>A0A7K2ZJR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_25705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="372" mass="38099" checksum="6441EE2992FB455C" modified="2021-04-07" version="1">MSKTDLNPAGTNLTTTNPTGTNPALSPGVRFGQVSFVWRPWLVLVTLVLAASAFLVFCLSIAVGDFPIGLSRVIATLLGQGEQVDEFVVMDLRMPRALAGLVVGIALGVSGAITQSVARNPLASPDILGITSGASAVAVFLVTVSGGAAAAIVGSVGLSAAALLGGLGTGLLVYFLAWRRGIDGFRLILIGISVSAVMQALTTWLLVSADIRDVARAQAWLVGSLDGRSWDEVNIAFWGALVLLVVVAAAAFSFKPMHLGDDVAAGLGVRYTRVRAVLLLCAVLLAAVAVSAAGPVPFVALVAPQVAMRLARFPTPPMVASGLLGALLLIGSDLIARTALPVTLPVGVVTAAIGGPFLVYLLVRANLRRTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJS2</accession>
    <name>A0A7K2ZJS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_25830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001202">
        <property type="protein sequence ID" value="MYW32598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="22151" checksum="B9F57CF996D961E0" modified="2021-04-07" version="1">MAKNAPPRWDRRMQQRLARGEAAALGELYDRFAALVHSQAHRMLDDEDAAGLVTREVFAQVWEDPEAYDPKQGSMRSWVARLTHRQSVQRLRRAAAVAYAEEHGEGAVPDPEELERRVRSATAAARADYIVSSMPASLRKALELAYTQRRDYRQAAADLGVTEDEARRRLRLGLQLLSTANTRPLEGSSPPGYGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJX1</accession>
    <name>A0A7K2ZJX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylcrotonoyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001210">
        <property type="protein sequence ID" value="MYW32643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="274"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="540" mass="57395" checksum="C78B48045EA0EFFB" modified="2021-04-07" version="1">MQQAPVLASAADPASEAWQANEAAHHALADELAARLATARLGGGEKARARHEARGKLLPRDRVDTLLDPGSPFLELAPLAANGMYGDQAPAAGVIAGIGRVSGRECVIVANDATVKGGTYYPLTVKKHLRAQEVALENRLPCLYLVDSGGAFLPMQDEVFPDRDHFGRIFYNQARMSGAGIPQIAAVLGSCTAGGAYVPAMSDEAVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGEVHSRISGVTDHLAEDDAHALRIVRNIVATLPDRAPLPWSVEPAEEPKVDPAGLYGAVPVDSRTPYDVREVIARVVDGSRFQEFKAEYGQTLITGFARIHGHPVGIVANNGILFAESAQKGAHFIELCDQRGIPLVFLQNISGFMVGKDYEHGGIAKHGAKMVTAVATTRVPKLTVVVGGSYGAGNYSMCGRAYSPRFLWMWPNAKISVMGGEQAASVLATVKRDQLGEDWSAEDEETFKAPIRAQYETQGNAYYATARLWDDGVIDPVDTRQVLGLALTACANAPLPQKDPAGPGFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK26</accession>
    <name>A0A7K2ZK26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001229">
        <property type="protein sequence ID" value="MYW32700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="26644" checksum="DD1881A5CE8887A4" modified="2021-04-07" version="1" fragment="single">MSGPAGGTARASAATDVVCLGESMVTFLPSQPGRLADVPSFGRGIGGAESNVACALAAAGHRAAWVGRVGADGFGDHLVETIGGYGVDTSAVRRDPVRPTGIYFRTATDRGAGAHEVAYYRAGSAASAMSPANVPYEEVFAGRVLHLSGITAALSADCLELVRELTAPRPGRPLVSFDVNHRPHLWRGGAADASVLLELARRCDLVFVGEDEAEEAWGIVGAEAIRAALPEPSVVVVKRGSAGATVFSGLRPGPRSSNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK84</accession>
    <name>A0A7K2ZK84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rplP</name>
        <name evidence="10" type="ORF">GT040_26635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966953.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001248.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZK84"/>
    <dbReference type="GeneID" id="63982131"/>
    <dbReference type="GeneID" id="66955247"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="139" mass="15842" checksum="B28000E40191951D" modified="2021-04-07" version="1">MLIPRRVKHRKQHHPKRSGMSKGGTQVAFGEYGIQALTPAYVTNRQIESARIAMTRHIKRGGKVWINIYPDRPLTKKPAETRMGSGKGSPEWWIANVKPGRVMFELSYPNEKIAREALTRAAHKLPMKCRIVRREAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKF3</accession>
    <name>A0A7K2ZKF3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplQ</name>
        <name evidence="7" type="ORF">GT040_26525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561896.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001248.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="18658" checksum="D15F6ECE78A133E5" modified="2021-04-07" version="1">MPRPAKGARLGGSAAHERLLLANLAKSLFEHGRITTTEAKARRLRPVAERLVTKAKKGDIHNRRLVLQTITDKSIVHTLFTEIAPRYENRPGGYTRITKIGNRRGDNAPMAVIELVEALTVAQQATGEAEAATKRAVKEDAAKKDEAKAESTEAVEDAKPVEKADEESKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKK2</accession>
    <name>A0A7K2ZKK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001267">
        <property type="protein sequence ID" value="MYW32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="33181" checksum="B6D582255ECD05F8" modified="2021-04-07" version="1">MVMEPPYLRIAGDIRRRIASGELAPGARVPSTRRITQDWGVAMATATKALATLQQDGLVRAVPGVGTVVAASGRERDAAPHSGLTRDRIIRAAIALVDGEGLVALSMRRVATDFGVSTMALYRHVPSKGELVRLMSEAVFDGEPPGSRPSGWRAQLEREARWLWTRYQRHPWLARAMAALTRPMASPHAMRYTERVLTALQGLGLTPNQIIHVHLALFGYAQGVAAAVELEAQARQDTGMTPEEWMASNELRLEEIQTAGSYPNLSTLFGEDEFDLELDTLFEFGLARLLDGVASLIERSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKP2</accession>
    <name>A0A7K2ZKP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_27455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001285">
        <property type="protein sequence ID" value="MYW32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18038" checksum="0A527649C80D9C35" modified="2021-04-07" version="1" fragment="single">APGPTGRRPERGARWRRVGLRLVALAALLALWQLVIVLQLWSPVLVPSPAAVWRALLETSGTHDGVRGYQGHTLIEHLGISLRRIFIGAGAGVVAGLVVGVLMGTLPWVRVVLEPAVAFLRTLPPLAYFSLLIIWFGIDEAPKLWLLAIAAMPPVAVATASAVASAPTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKW3</accession>
    <name>A0A7K2ZKW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001300">
        <property type="protein sequence ID" value="MYW32983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="372" mass="39493" checksum="FD28D4352E25933C" modified="2021-04-07" version="1">MTSINEQPIPAARPVIGEDEIEAAVRVLRSGRVVQGPEVAAFEEGFSRLVDGRHCIAVNSGTSALQLLLLALGIGPGDEVIVPSFSFAASANAVRLTGADVVFADIEPGGFGLDPAAVEAAITPRTAAVMPVHLYGHPAAMDKLMPIADKHGLAVVEDACQAHAAALNGTPVGAFGAGGTFSFYPTKNMHALEGGMVTTADAALARTLRLLRNQGMEQRYANEIVGANMRMTDVSAAIGRVQLAKVEEWTEQRRANAAYFDAHITAPAVTTPPVAQGARHVYHQYTVRVRGDRDAAMAGLTEAGVGNAVYYPTPIHRLKPYWEPDQKAGRTWELPETERAAAEVVSLPVHPSLTRNDLERIVTAVNSLGENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKX9</accession>
    <name>A0A7K2ZKX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001302">
        <property type="protein sequence ID" value="MYW33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="18775" checksum="DCBF5952FA7C9604" modified="2021-04-07" version="1">GHTLTDEEGAGVLGRTCADTAAYLATLSPRAVSDRALESDLEDTFLTAVEKGVRLRPGARDLLDRLADGNIPAALVSASPRRVVDAVLKTLGAEVFRTTVADGETDRSKPHPDPYLEAAARLDLPPGACLVVEDSPTGIAAAEAAGCRVVAVPSATPVDAAPGQRVLGDLTALLHTWGPYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL04</accession>
    <name>A0A7K2ZL04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_28120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001307">
        <property type="protein sequence ID" value="MYW33036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="260"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="506" mass="54163" checksum="E09E03EEC67C5F4C" modified="2021-04-07" version="1">MTHRSAKDPAAPVLALRDISKSFGAVRALRDVSLDLFPGEVHALAGENGAGKSTLIKTLAGVHRPDAGQVLLDGEPTVFHGPADAREAGIAVIYQEPTLFPDLSIAENIFMGRQPRRALGRIDHRATRTATTALMRRLGVALDPDRPARGLSIADQQIVEIAKALSFDARVLIMDEPTAALTGSEVARLFTVVRTLREQGAAVLFISHRLEEIFRICERVTTLRDGALISSEPLGGMTEEDLVRRMVGRDLDELYPKQEVAAGPVALSVRRLTREGVFTDVSFDVRCGEIVGLAGLVGAGRTEVARAVFGVDRWDAGEVEVAGRALTNGAPSTAMAAGLALVPEDRRAQGLVMDMSIERNIGLTGLRTTVKAGLMDRVAERSRSLDWAVRLQVKYARIADTVGTLSGGNQQKVVLAKWLATDPAVLIVDEPTRGIDVGTKAEVHRLLSQLAVDGVAVLMISSDLPEILGMADRVLVMHEGRLTAELPRSEATEETVMAAATGRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL19</accession>
    <name>A0A7K2ZL19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_28150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001308">
        <property type="protein sequence ID" value="MYW33042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="85"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="22932" checksum="2876A7DDAB95263A" modified="2021-04-07" version="1">MSFGDPNNPYGQQPGQPPQGPPQGQPGYGYPQQAPQGVPQQGYGYPQQQPGYPQQPGYPQQPGQPYGGGYPQGQPGYGGGMPELAHWGLRAGGLIIDGLIIGAPYLVLAGIGGAMGDSAGGFIVLIGFLLMIGLSLWQLYQEGTTGQTIGKKAVGIRLLREADGRPLGFGMAFVRRLAHFLDSIACYIGWLWPLWDEKKQTFADKVCSSVVIRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL90</accession>
    <name>A0A7K2ZL90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation/acetate symporter ActP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">actP</name>
        <name evidence="8" type="ORF">GT040_28610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001328">
        <property type="protein sequence ID" value="MYW33127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="530" mass="54883" checksum="F0871A9628337012" modified="2021-04-07" version="1">MRGDHQTLALLLFCAFIAVTLFITTWVSRNRQGSAEEFYAGGRLFSPMENGFAIAGDYMSAASFLGISGLIALFGYDGMLYSVGFLVAWLVVLLLVAELVRNCGRFTLADVVAARMAERPVRIALGTSSVTVSVLYLVAQMVGAGSLVALPLGGTSDAARTWTVVGVGALMVVYVSFGGMRATTWIQIVKAVLLMGGAVALTVLVLVQFRFDVDSLLTTAAERSGHGKDFLVPGLRYGGDWISRFDFISLGVALVLGTAGLPHILSRFYTVPTARAARRSVVWSIGLIGSFYLMTIVLGFGAAALVGSAEVRSSNAAGNTAVPLLALNLGGGEGSTGGTVLFAVVAAIAFATILAVVAGITLASSASVAHDLYASIRRPGRKQYGEVAVARVAAAGIGAVAIALGLLAQNLNVAFLVGLAFAVAASANLPALLYSLFWRNFTTRGAVWAVYGGLVPAVVLVLVSPVVSGSPASLFPGVDFQVFPLENPGLVSIPLGFLAGWLGTVTSREKPDEAKHAESEVRALTGAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLD5</accession>
    <name>A0A7K2ZLD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001310">
        <property type="protein sequence ID" value="MYW33059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029752998" evidence="2">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="13741" checksum="8A650A71091B1799" modified="2021-04-07" version="1" fragment="single">MTIPRRSWRAAGTLVAATVVGLTGSILSAGPAAAHTPTWDVTCSEVTVDLTYYTPDVPNTVTVTVDGKDLLPTKTFGKEFSTKLTLPEHSEKLTVRLVVKDGSKGGKYSYEDEKTADVCEGETPTPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLI1</accession>
    <name>A0A7K2ZLI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001355">
        <property type="protein sequence ID" value="MYW33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="190" mass="20109" checksum="F0131210879FA1F1" modified="2021-04-07" version="1">MDVRQGSDGQTVIHFRAAGVTLLLAHLLLVGWLTLRPLDVPWITAANFEPLASIRADLALGPVEAARRIGGALLLLAPLGVLLPMAGGRIFVSPWVSLLRTVAAGALISLAIELGQTGVPGQVVDIDSVLLNTAGVVLVHLLVVPVCRARLRRRGVPGVRDLPRYRQETRLRDEAPGGSTPTITRVGIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM01</accession>
    <name>A0A7K2ZM01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_29995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001387">
        <property type="protein sequence ID" value="MYW33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="31420" checksum="2A80BB9C725D2F92" modified="2021-04-07" version="1">MKAGRRTEGRKADGRKRRRRAPRAWFGALPLLLFAGLCFGLPAGALLYGAITRTDPVAGTTEFTGEHLQRSLQGPYLTSLTGSVELSALTAAIATVFGVLIAQAVVTSRRGALRGAVLTASGVLANFGGIPLAFAFVATLGISGVVTQLGHLDALGWNLYSFTGLTVIYLYFLIPLMVIVVVPALDGLRPQWREAARNNGATAWQFWRYVGLPVLAPSLLGGFVLLFGSAFAAHATAAALVGGSVPLVTLKIADALSGNVLVGQENVALALSLDMIVIAGLVMAVYLPLQRRSSRWLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM52</accession>
    <name>A0A7K2ZM52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polypeptide N-acetylgalactosaminyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029772472" evidence="1">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="49"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="167" mass="17588" checksum="27F94DC9997DDA56" modified="2021-04-07" version="1">MAGVLRKLLVPALLALTPFALPSPVVAATPAPAAPTASAASVAPAAGVMCLNSNYPTTRIVNVVPCSSGAGQRWTISGEAIFQSAHPGMCLTSDYPRSRIVNVEPCNSSTRQRWTISGEAIFQSAHPGMCLTSDHPRSRIVNVEPCNPSGIRQHWTVLGEQISMTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMI0</accession>
    <name>A0A7K2ZMI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001414">
        <property type="protein sequence ID" value="MYW33520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="14155" checksum="4CCF96B741671A6E" modified="2021-04-07" version="1">RHASETATAAQGLDDRPWYDARRLDIDLLLWRLRDHPDLAAFVNRAIGPLREHDRTSRPPLLPTLQAYLAHAGRKAETARELHLNRQTLYNRLARIGELLGTDLDDPQTVLALSLALRARRHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMU4</accession>
    <name>A0A7K2ZMU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylacetic acid degradation protein PaaN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">paaN</name>
        <name evidence="4" type="ORF">GT040_31390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001438">
        <property type="protein sequence ID" value="MYW33650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011975">
        <property type="entry name" value="PaaN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02288">
        <property type="entry name" value="PaaN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="107"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="578" mass="61457" checksum="30CFE1D82D928014" modified="2021-04-07" version="1">MTTARSERAAAEAAQDLLTRHRAPLERAVTAIRTREYWSPYPDEAAAYGELARTAGDEAFHRLLGQEFASDQPGRDGSVGPGPEDGGESSPYGFGLGITYAHADPDVLLPAMEAAMAGWREAGPWGRAAVCAEILERINARSFELAYAAVHTSGHNFLMAFHAGAVHAQDRGLEAVAYALSEQTRMPTEVTWSKPMPDGRVFSLAKTFTVVPRGVSLVVANRVFPTWNGYPGLFASLATGNAVLVKPHPGAVLPLALTVRIAREVLRESGFDPNLVALAPERPGERLAATLALRPEVRIVDYAGTSEFGQWLEANARQARVFTAKSAVNSLLVESTADYRGMLHNLAFSLALYSGQLCTSPQNLLVPRGGIATDQGHRTYAEVVRDLAATVTALLTEDESAIAVLGALVGLDVLADVEHAASGAIGPVALAPRAVAHPDHPQATVRTPVLVALDASREEDHQTFGREWFGPVGFVVAVDSAAHGAEVLGAVTRRAGALTVGVHTTSPEVEALVAEVCERAGVMLSVNLMGDWFITQSAVYSDLHGTGLNPSGNSVYCDGAYVAERFRTVGVRRYGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN60</accession>
    <name>A0A7K2ZN60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_32010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001458">
        <property type="protein sequence ID" value="MYW33770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="75"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="352"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="692"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW33770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="748" mass="79920" checksum="624D7A35CC3E0A21" modified="2021-04-07" version="1">MGRADARRARAQESRRAAKSGGIRRLFTWKKLLGTFFGIVLLGMGAFGALYLYVDVPAPNALAERQSNVYQYSDGTVLARSNGDVNRQIVDLAQVPKEVQHTFVAAENKTFYEDDGIDLKGTTRALLNTLSGKGKQGGSTITQQYVKNYYLTQDPTISRKLQELVISLKVDQDQSKGQILAGYINTAYYGRGASGIQAASQAYYGIDAKDLNVSQGAYLASLLQAPSQYDWATATDTGKRLVKDRWAYTLKNMVEMGWLSEAERAKQEFPVPDKPKPAQGMEGQTGYLVEAVNKELDKQGISAEDREAGGWTFTLTVDKKRQQQLEKSVEKELESKLDRKGSKIDATVQAGATSVDPKTGKVVALYGGEDYVKHYISNATRQDYQPASTFKPLVLAAALENESKTQNGNLIGLNTIYDGTSKRPVVGSDTAFAPQNEDDRSYGPISVQRAMNSSVNSVFAQMIVDVTPAATKRTALGLGVPDKNFPERPAVTLGTMNASTWDMAGVYATLDNHGRKVTPHILQSAEHRDRTVKPQAPKKEQAISRASADTVTSALTGVVKSGSGSAASTSAYQAAGKTGTSEENKSAWFAGYTPELTTVVALFGEGDGGRKQVSLTGTANSGRANGGGFPARIWADYTLGALGGGSDARFDLQDVERGEVPPPPTPSKTPSEEPTPSEEPTPSKTPSETPSETPTSEPPPSSPPTPSTPPTITPPTVPPTKSPELPPQPGESDGQPGERPGGGGLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNB4</accession>
    <name>A0A7K2ZNB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">nuoK</name>
        <name evidence="6" type="ORF">GT040_32440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001486">
        <property type="protein sequence ID" value="MYW33853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510682.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001486.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="10701" checksum="5BE6ECD97561F709" modified="2021-04-07" version="1">MNPVNYLYLAALLFAIGASGVLIRRNVIVLFMCVELMLNACNLALVTFSRMHGNLDGQIVAFFVMVVAAAEVVVGLAIIVSLFRSRHSASVDDASLMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZND7</accession>
    <name>A0A7K2ZND7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001487">
        <property type="protein sequence ID" value="MYW33866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="25441" checksum="23FEFBBCFD5B6A6F" modified="2021-04-07" version="1">MGSTGTVLRELRGAQKSAKGVSLYSRYVNRPTGRVLAAGAYRAGLTPNQVTLISALLTYAALAAVALVKPSWTLALLVYAALAIGFAFDSADGQLARLTGRGGPDGEWLDHVVDCGKLVLVHTAVLISFYRFGELPSHAWLLLPLGFQLAAVVTFCAGLLREKLGKAAVAGAPAGSTAAPASQLRAFALLPADYGVFCLVFLLLGVPGAFRAGYAVLAVVHTLFLAAFLTKWFRELRALRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNL9</accession>
    <name>A0A7K2ZNL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001501">
        <property type="protein sequence ID" value="MYW33940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15512" checksum="4B60F9F0395040B1" modified="2021-04-07" version="1" fragment="single">MTVHQHAVDVGTFAQYLREMTARLDPGRGWYGVFTRRDPQGMRSCLDGVEIPPWDVVESLLADLAEVHGAYFAEQVSVRAAALYSASAAAHDRRPGGRQELVHRLELMIREQGRAAERLRPPGAGGVDPADPEALAWAHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNT6</accession>
    <name>A0A7K2ZNT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S58 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001533">
        <property type="protein sequence ID" value="MYW34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="5679" checksum="0D253188A20AAE4D" modified="2021-04-07" version="1" fragment="single">MPEGGPLLDALTDVAGVRVGHAQVGGAGALSGTTVVLAPEGGAVAAVDVRGGGPGTRETDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP89</accession>
    <name>A0A7K2ZP89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001541">
        <property type="protein sequence ID" value="MYW34079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="24796" checksum="3D63F77F776DFB21" modified="2021-04-07" version="1">METTRGAERQRTAAEARRRELLEAADRVVLRDGPQASMNAIAAEAGITKPILYRHFGDKGGLYRALAKRHTDALLSALRAALDAPAERRARVEATLDTYLAAIEARPQVYRFLMHPADGAADSATSAEVALSPEQGFDVGRHSAPLLRRLGEELGQVIVERVDLGPDGEQMARIWGHGIVGMMHAAGDWWLADRPCSRERLVRSLADLLWGRLTEAGDRDVKGGPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPC9</accession>
    <name>A0A7K2ZPC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001570">
        <property type="protein sequence ID" value="MYW34221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="25984" checksum="BF2F721FEB9B9CCE" modified="2021-04-07" version="1" fragment="single">MRPATATATAVTTILGAGAAAVAAGRYASDAALKAAPGRPLPTDRRLTVHATGIRRVTLTRSLTALRPGTYGIEGPGVHAVVGPVVEGAESTADTVVRTLERVTHGILEPGDKVRLTPEVYRGDPGTALGLEYREVEIPGELGGLPAWWVPGDRDTWVITAHGLGTTREHPMNLMGFLSGRQLPVLDLAYRGDAGAPRPADGLGHLGASEWRDLDAAMRFAVRYGARNVILYGWSTGASMALHAAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPK3</accession>
    <name>A0A7K2ZPK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_34180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001557">
        <property type="protein sequence ID" value="MYW34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="423" mass="42800" checksum="7C3CBF0B23C76941" modified="2021-04-07" version="1" fragment="single">MAAASAPGEIRVASPVGRWVVLTTVLGSGMAMLDSTVINVALPRIGADLDTDLAALQWTVNAYMLTLAGLILLGGALGDRYGRRRVFVVGIVWFALASLLCGIAPNAGVLIAARALQGVGGALLTPGSLALIQASFHPDDRARAVGLWSGFGGVGAAVGPFVGGWLVDGPGWRWVFLLNLPLAAICVPVALRHVPESRDPAAHGRFDVLGAALGALALAGVTYALIEAPEQGASPLVIGAALGGVLLGVAFVLVEQRRADPMLPPSIFRSRLFTSVNLVTFCVYAALGGFFFLSAIQLQVVAGYSALGAGTALLPTTVLMLLFSAWSGELGRRIGPRIPLTVGPLLAATGMLLMLRVGPGSASFGGYVSEVLPAVTVLGAGLVVVVAPLTATVLAAVDTGRAGLASGINNAAARAAGLIAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPP5</accession>
    <name>A0A7K2ZPP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001585">
        <property type="protein sequence ID" value="MYW34258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="42"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="471" mass="51630" checksum="7DE091C9358055DB" modified="2021-04-07" version="1">MAPAAMSTAAQSLSGAKPVSYWLDDPAKPDALPALTGDEHADLLVIGGGYSGLWTALIAKERDPGRDVVLIEGHEVGWAASGRNGGFCAASLTHGLANGVQRWPDEIAKLEELGERNLDAIEAAVARYGIDCEFERTGEIDVATEPHQLEELREWHEELVKLGITGVDFLDRDALRAEVDSPTFLGGLWDRNGVAMLHPAKLAWGLKRACLELGVRIYEHTRGLDLVRSGPGMAVRTPYGRIFARRVALGTNIFPSLVKRVRPYTVPVYDYALMTDPLTPEQLESIGWKGRQGLGDSANQFHYFRLSADNRILWGGYDAIYPYGGKLSADLDQRPETFLKLAEQFFDCFPQLSGLNFSHAWGGAIDTCSRFTAFFGTAHQGRVAYAAGYTGLGVGSTRFGADVMLDLLAGEETERTRLEMVRSKPMPFPPEPFAWAGIEITKRSLARADSNGGHRNLWLKTMDKLGLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPX5</accession>
    <name>A0A7K2ZPX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_35355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001622">
        <property type="protein sequence ID" value="MYW34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="16"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="422" mass="43206" checksum="3E9F9DE852FE73DB" modified="2021-04-07" version="1">MHDTTALLVELGAVILGLGLIGRVAGRIGLSPIPLYLLAGLAFGHGGLIPLDASEEFTMVGAEIGVILLLLLLGLEYSASELVTSLKTQYPSGAVDFVLNATPGAVAALILGWGPVGAVALAGVTWISSSGVIAKVMTDLGRLGNRETPVILGVLVMEDLAMAVYLPLLTAMLAGVSLAGGSLALVIALGTVGFVLYLALRHGRLISRAVSSDNPEMLLLVVLGLTVLVAGVAQQLQVSAAVGAFLVGIALSGEVAEGARKLLTPLRDLFAAVFFVFFGLSTNPADIPPVLLPAAILAVVTVLTKIATGWYAARRAGIGSRGRWRAGGTLVARGEFSIVIAGLAVATEPRIGPLATAYVLILVIVGPLTARWTQPLAEKIQAARGVKPGGPAVEAPPKAAPERRLGDHDELTPEPAGEARGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ07</accession>
    <name>A0A7K2ZQ07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="12" type="ORF">GT040_35110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001603">
        <property type="protein sequence ID" value="MYW34368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
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        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="99"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="100"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW34368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="517" mass="55347" checksum="C8EF1E4AF3F4C91E" modified="2021-04-07" version="1">MFDTLSDRLSATFKNLRGKGRLSEADIDATAREIRIALLEADVALPVVRAFIANVKERARGSEVSQALNPAQQVVKIVNEELVSILGGETRRLRFAKTAPTVIMLAGLQGAGKTTLAGKLGLWLKGQGHSPLLVACDLQRPNAVNQLSVVAERAGVAVYAPEPGNGVGDPVQVAKDSIEFAKAKVHDIVIVDTAGRLGIDQELMQQAADIRDAVSPDEILFVVDAMIGQDAVNTAEAFRDGVGFDGVVLSKLDGDARGGAALSIAHVTGKQVMFASNGEKLEDFDAFHPDRMASRILDMGDLLTLIEQAEKTFSQEEAAKMASKLQSSKGGKDFTLDDFLAQMEQVRKMGSISKLLGMLPGMGQIKDQINNIDERDIDRTAAIIKSMTPKERAEPTIINGSRRARIAKGSGVEVSAVKSLVERFFEARKMMSKMAQGGGMPGMPGMPGMGGGPGRQKKQVKQAKGKRKSGNPMKRKAEEAAAAERREQAAAQGGALGLPAQEDKNFELPDEFKKFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQW7</accession>
    <name>A0A7K2ZQW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_37220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001686">
        <property type="protein sequence ID" value="MYW34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029578245" evidence="2">
        <location>
            <begin position="38"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="3">
        <location>
            <begin position="251"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="530" mass="56542" checksum="8CF6838EFAFC5E64" modified="2021-04-07" version="1">MTTVRITRTALTRGTLAALSGLLAGFAALTVAELVSAAVRPEASPVTAVGGAAIDRTPAAVKDFAIRNFGENDKLVLQLGIVVTLALFALAVGVLALRHRRTGSAAVLAFGVVGAASAVSRPDSTGVVDGLPSLVGAVAGAFLLYVLIGRLLRPRRVAGEEEQENEGGWDRRGFLVAATAAAAASTVAGAVGRTLNGRSAQDAVASREAARLPAPASPAKPIPAGARLRVPGLPPFTTPNSKFYRVDTALVVPKVDANSWRLRIHGKGVRRDLEFTYQDLLDRPLIEREITLCCVSNEVGGPYIGHARWIGVRLADLLKEAGVKPPSRGGKADQIIARSVDGMTLGTPVEDVMDGRDAMLAVGMNGEPLPFVHGFPVRMLVPGLYGYVSACKWIEDIELTTFDDYDAYWVKRKWARKAPIKTQSRIDTPKPFGRPEAGTVMVAGVAWAQHRGIEQVEIRVDDGPWRPAQLAEQDTVDTWRQWSYPWKATPGGHTLTVRATDGTGEVQTEKRTKTVPDGASGWHSVVVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR22</accession>
    <name>A0A7K2ZR22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin biosynthesis protein CobW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001683">
        <property type="protein sequence ID" value="MYW34747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="1">
        <location>
            <begin position="242"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="385" mass="41384" checksum="BB33B1D31E855F8C" modified="2021-04-07" version="1">MTAEPRRKLPVVIVCGLHAEVRHEVVETLLSQVPHSVALHHDLSTATDGTVRRTLRDATGELSAGETPLVNDCACCALREDLVPELQRLADSGLTRLAVLELWDSVEPKSMAEVIAVHGAGSFEVTNVITALDPTLVLPCLTNGDDLAEAGLAAAPADQRTIGDTWARQVEYAPVLAVADSPAADDEDRALIRQINPMARQVASDSAELARLAVAGFDVEAAAAGQHPACALLPQEAEEAGVSTLVWRRHRPFHPERLYHALEDLCCAAARSRGRFWLADRPDTLLSWDAAGGALCVENTGPYLASLPDAAWALVPPYRQAAAALDWHPEHGDRCQHLVFVSPGLDRDGLTGLLESCLLSDEEYRAGREAWKSLPAAFDALLDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRE1</accession>
    <name>A0A7K2ZRE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001700">
        <property type="protein sequence ID" value="MYW34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="6224" checksum="0A3940DDBEB8236C" modified="2021-04-07" version="1" fragment="single">MQLTEPHIRVGAYALGVLGRADAFRFEEHLEECPPCRVRARELAPIAARLAVARPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS69</accession>
    <name>A0A7K2ZS69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001793">
        <property type="protein sequence ID" value="MYW35206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="82" mass="8856" checksum="321DA4FEAC49C50C" modified="2021-04-07" version="1" fragment="single">MNDPRNVHNHEGPVFNEAVSGAQFAWNNQSVTQNQQNNSTVAPGFEALAALVDDLLQQVPRAGLAERDREDVEAAAGEVRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSJ5</accession>
    <name>A0A7K2ZSJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ORF">GT040_40115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001833">
        <property type="protein sequence ID" value="MYW35315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015608864.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001833.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW35315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="446" mass="48020" checksum="0100CBCF6A71B1F0" modified="2021-04-07" version="1">MTGTDDVLLVHGGTPLEGEIRVRGAKNLVPKAMVAALLGSGPSRLRNVPDIRDVRVVRGLLQLHGVTVRPGDEPGELILDPSHVESANVADIDAHAGSSRIPILFCGPLLHRLGHAFIPGLGGCDIGGRPIDFHFEVLRQFGATIEKRADGQYLEAPQRLRGTKIRLPYPSVGSTEQVLLTAVLAEGVTELSNAAVEPEIEDLICVLQKMGAIISMDTDRTIRITGVDKLDGYTHRAIPDRLEAASWASAALATEGNIYVRGAQQRSMMTFLNTFRRVGGAFEIDDEGIRFWHPGGALNAIALETDVHPGFQTDWQQPLVVALTQAAGLSIVHETVYESRLGFTSALNQMGAHIQLYRECLGGSDCRFGQRNFLHSAVVSGPTKLQGADLVIPDLRGGFSYLIAALAAQGTSRVHGIDLINRGYENFMDKLEKLGAKVELPGGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZST9</accession>
    <name>A0A7K2ZST9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="81" mass="8638" checksum="613029216355C19F" modified="2021-04-07" version="1">MSTTDLAWFKSSYSGGDGDSCVEVALEWHKSSYSSGSGDSCVEVAACPSTVHVRDSKIEESPQLALTPTAWTRFLSYAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSV6</accession>
    <name>A0A7K2ZSV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001851">
        <property type="protein sequence ID" value="MYW35436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="164" mass="16967" checksum="A26D7CF663350902" modified="2021-04-07" version="1">MDHDRTAAPLSADEADARARQLITEAYAPPYEVPTSYRDETEPTAYVPTPPVAQPGRPPMSQRATDASALMLSGSVAALSVGGATSLVLYTLGQVDPVTLAIGATGPVALVLAAGSLLKAVGRAKAAAAPTEVHNHYTGPVRQESTTVSSTTKGLFAKNRNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5W3</accession>
    <name>A0A7K2Z5W3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">GT040_00190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000003">
        <property type="protein sequence ID" value="MYW27729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073719522.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000003.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW27729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="133" mass="14624" checksum="757D26C998425EFE" modified="2021-04-07" version="1">MPLPPWGSLDSGEDGAGMGWVTDWSAQAACRTTDPDELFVQGAAQNRAKAVCTGCPVRTECLADALDNRVEFGVWGGMTERERRALLRRRPTVTSWRRLLETARSEYERSTGILPAVIGLEDDELHETYAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6K4</accession>
    <name>A0A7K2Z6K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_01385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000060">
        <property type="protein sequence ID" value="MYW27958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW27958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="386" mass="39783" checksum="55C8FB921314D5F7" modified="2021-04-07" version="1">MSDTTAEAAPEATTTPAPAPVGASSLTDRLRRPRTYAVLVASVLLLALPFYLDRFWLQAGLFAMAAAIGAIGLNMLTGATGQLSMGHAFFLAVGAYGYCILAGESSTENGHTLTGLGLPTWLAAILAVLLAGAAGGVFSPIAGRLRGAYLGIATLALIFIGQHVLFNAGSLTGGYNGRAVPPLSLFGFTFDDTEVVVAAVPFGSSEKLWYVGLAALLLSALFARGILRGRPGRAMNAIRDHRIAAGVMGVPVARYRAGVFVLSSMYAGLAGVLLALVFQRTVPEYFGMILSLEYLAMIVIGGLGSVAGAVVGAFFVSLLPQVLTHYSDSLPLVSAPGTGGLAPGEASRYLYGAAVVAVVLFLPGGLARLGIALPRVNRPKKSGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7T7</accession>
    <name>A0A7K2Z7T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000149">
        <property type="protein sequence ID" value="MYW28375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="27274" checksum="FCE7A389FF03614D" modified="2021-04-07" version="1">MIRPRLSSTIERRLLVNYRVDPPVAAALLPAPLRPQLVRGRAVAGICLLRIGGVRPGWAPAATGLTSENAAHRISVEWDGPDGVEHGVYIPRRDTASRLNVFAGGRIYPGEHGRADFTVREEADAVRVAFATRDGEVEVDATVEPAEELRGSGLFTDLAEASEFFRLGSRGLSPNARGTHLDVLELSTEAWKVTAGRPRTVRSSFFEDPDRFPPGSAVLDSALVMRGVAADWSQGEPFRVGARDTSPPGSPGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z877</accession>
    <name>A0A7K2Z877_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000197">
        <property type="protein sequence ID" value="MYW28523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6746" checksum="42A368C3D32EBD19" modified="2021-04-07" version="1">MVKLSVVMPFFDVRTYAPDAFGILRADIREDFAFRPRSSPAATKKPNNTGSAEKAEKAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8M1</accession>
    <name>A0A7K2Z8M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dabb family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000221">
        <property type="protein sequence ID" value="MYW28645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="11234" checksum="6DEDCF5B1790F035" modified="2021-04-07" version="1">MIRHLVLFKLNDGVERDDPRVVAGDRAFRELEGQVPELEFWECAWNITDRPIAYDYAINSAVADEAALKRYIEHPAHQAAAGQWREFATWVIADYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8R1</accession>
    <name>A0A7K2Z8R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000247">
        <property type="protein sequence ID" value="MYW28712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="15223" checksum="8942B0F2FE93784A" modified="2021-04-07" version="1">MTFSVDVTVRGYELDTQGHLNQAVYLQYAEHARWELLRAAGLPQEKLLADGIGPVQLEVTVKYRRELRGGEKVRVTCRFDYGTGKTFTLAQQVIKEDGTVAAEITGVAGVLDLTERRLVPDPQRRLAALAGNPDLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z927</accession>
    <name>A0A7K2Z927_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyphosphate kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000269">
        <property type="protein sequence ID" value="MYW28860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="2">
        <location>
            <begin position="77"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="187" mass="21520" checksum="015EBDAB3A7980E4" modified="2021-04-07" version="1" fragment="single">MTRSTKAHGGRNGRNGDNGAKKKRTAREEAARAARYGGPYLDGFQVADSGDDDPVLVEPDGHARDAWREDYPYTSKLRRRDYEKAKRALQIELLKLQHWVKERDERLVILFEGRDAAGKGGTIKRFTEHLNPRGARIVALEKPTERERTQWYFQRYVAHLPSAGEIVLFDRSWYNRAGVERVMGFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z962</accession>
    <name>A0A7K2Z962_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000277">
        <property type="protein sequence ID" value="MYW28873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="PTHR43176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="364" mass="38477" checksum="5CF8620128EBDA4A" modified="2021-04-07" version="1">MIDDRPVLLETRGRSLHIILNRPRAINALTPTMVRLLDEALTGAEQDEAVTSVVLAGAGDRGLCAGGDIRALHDDTRAGGRASLDFWRDEYRLNARIARFPKPYVALMDGIVMGGGIGVSAHGSIRIVTERTRAAMPETGIGFVPDVGGTHLLAASPGELGTHLALTGRSVGAADALLCGLADHHVPTRRLPELTEALAGTASADEVARTVQRFAEEPPAGELAAQRDWIDACYAADTVEEIVRRLRACSARAAADAAAELAGRSPLALKVTLAAVRRAARLGSLEAVLDQEFRVSGRIREEPDFVEGVRARIIDKDGSPQWKPATLAEVDDSAVARFFAPLGPDEQELGLAPYAPAAPADGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAB1</accession>
    <name>A0A7K2ZAB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000379">
        <property type="protein sequence ID" value="MYW29273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="6307" checksum="27ABA0EE12F8306D" modified="2021-04-07" version="1">PAALAAADGPGERAIIKDAFASGLETSQLAGAVAVLAGGLLAALLLRRAERTEAAAGRAKAVGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAF2</accession>
    <name>A0A7K2ZAF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_08625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="26598" checksum="A7DA2136ED0995E3" modified="2021-04-07" version="1">MSLLSVNDVSYSYDGIVNVLLDVSFTVEEGTIVGLVGPNGSGKSTLIKNIFDLVAPQSGSIQIGGHGHDRPEAKQLAMYLSSNDYLPEFLTAREYISMMGELFRLDVDHGQALELFRKFSMDGRYDDLIEDYSHGMRKKTQLVSSLVMRRSLTVVDETLNGIDLEALHLAEKEFGKIRSEGRSLLLCTHDFSVLERLADRILFLDLGHVVYDSPTNTLVEEHGSVADMVFDYLETAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAQ3</accession>
    <name>A0A7K2ZAQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsfS</name>
        <name evidence="3" type="ORF">GT040_09140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000415">
        <property type="protein sequence ID" value="MYW29436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030563602.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000415.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="143" mass="16008" checksum="1DA0FF8461E10C9A" modified="2021-04-07" version="1">MTATDRSIELINAAAQAAADRLAHDIIAYDVSDVLSITDAFLLASAPNDRQVKSIVDEIEEQLQKQLGAKPVRREGDRDARWILLDYVDIVIHVQHSEERVFYALERLWKDCPEIALPEDAIKTRGKAEEHAQLNGSTEGDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB89</accession>
    <name>A0A7K2ZB89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000465">
        <property type="protein sequence ID" value="MYW29637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002169">
        <property type="entry name" value="Peptidase_M9A/M9B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01752">
        <property type="entry name" value="Peptidase_M9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00931">
        <property type="entry name" value="MICOLLPTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="276" mass="30695" checksum="99868AA1B4328E7D" modified="2021-04-07" version="1">GPAVTAPSDAPTAVRSSAPAKVATQAVNSTLPVDHSCSSTLRVRAQQMTSGQLSSVCTSLAGQAAYFHNVVKSNSQPVRGDNNASLEVVVFNSSSEYRRLAGSLYGVSTNNGGVYLEGNPSAPGNQARFIAYRDETASAFTVKNLNHEYTHYLDGRFNMYGDWNANISTPTLWWIEGLAEYVSYGYLRRHNTWAAGEASRQTYNLSTLFDTTQQHDQDRVYAWGYLAVYYLMENRPADVTKILGYYRAGSWQAARTYIKQNIGTRYDADFRRWLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBI9</accession>
    <name>A0A7K2ZBI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000465">
        <property type="protein sequence ID" value="MYW29635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029616689" evidence="1">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="14219" checksum="54B7F25115BBFAD4" modified="2021-04-07" version="1" fragment="single">MSRHTGRRVAVTVLSAAALWSPTAQGAAVADSPRPVVETLPEQEVRVAVAAARTPGAVNLARSNLGISAGQSAALRVEDRGTVVHHLDPAFAERGGRLPLAVPGYVAVTAHAGDGRAVTLQVARVVPAGGGGPRWTAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBM4</accession>
    <name>A0A7K2ZBM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="691" mass="74898" checksum="316CBD61E39A329C" modified="2021-04-07" version="1">MTDTAAPAAHLRPVPDLDDTETAASVAVDNPALPEPRVSVEKRKPVLAGWLTDRRDFTATARHAGANAGYSALFHGVRLPVYAGRLALMSPRGACRFIATSNRWIWDREAAPLRAAAVRAEDVEEYMRLARLRAGRVRLRGLVALVAAVFGVGFALWLYVMAPALMYAFAAGGVLLLGMAGQQPDAPVIGPAVLKTEVQKLTGSIVLRGLDSVGNSRISAAIKKGGDMNGLRFTSEIVRDGPGYRADLDLPYGVTPEDIMEARKPLASGLRRKVGCVWPSPDPTEHEGRLVLWVGDKPMNETTKPAWPLLKTGQVDLFRPVVFGNDQRMRDVSVTLMFAAVVVGSIPRMGKTFLMRLFLLIAALDPRAELHAFDFKGTGDFGALEPVCHRYRAGEENDDIEYVLDALRELKEELRRRAKVIKSLPRSRCPESKVTPELASDKNLGLHPIVAGFDECQVPFEHEEHGKEIEAICTDLVKRGPALGIVTLFGTQRPDAKSLPTGISANAVLRFCLKVMGQPANDMVLGTSMYKAGYRATMFSRSDRGICWMAGEGDDPRIVASAFVDAVAAEQIAARARQVREEYGNVTGHAIGAGPEKSGHSDVLADVLSVIAPDEKAVWCERLAARLATAQPEVYGGWKGENVTAALKPHGIKAGQVWGQTDTGEGKNRRGIDRADITTAITRRNQNKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBT5</accession>
    <name>A0A7K2ZBT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000500">
        <property type="protein sequence ID" value="MYW29803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="168" mass="17380" checksum="A8286CB93BFA1ADA" modified="2021-04-07" version="1">MTASPELAPSLTASPELLRSVFRRHAAGVAVITAAGQRPVGFTATSLNSVAAEPPLVSFGIGTSSSSWPVLAEAEYVGVHILGEHQQELAATFARSGADRFGPSTDWSSGPEGVPLLAGVSAWLVCRVVTRVPAGDHRIVIAEAVAGDPSGAGRPLVYHQGRFTALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBU1</accession>
    <name>A0A7K2ZBU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000504">
        <property type="protein sequence ID" value="MYW29826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513656.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000504.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7167" checksum="4E7626C6851FBFB5" modified="2021-04-07" version="1">MAHNPHAPQPGPEGTPDPAGSTQMFRAFVDEGEPQRRAQPAATSSGPRVGVIAAVVAVVVVLGAVAWLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC18</accession>
    <name>A0A7K2ZC18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000522">
        <property type="protein sequence ID" value="MYW29883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="221" mass="24610" checksum="663F8D6724B74F0A" modified="2021-04-07" version="1">ARRRRGRGTIAALAAEEVLRGWGCTHVRTEVPADNDPARRLAAALGYTERSRNMVKTLGPDTVPLPEGLTARPMSEQEYAEWLREAVRSYAQEWTDRGVPPEQARLKSEADHAGNLPEGLATEGVRFRVLVHGGAVVGHVWLALRELEPGRTAGFVFDVEVREEHRGRGFGRALMLLAEYETRSWGRDRLGLHVFAANVPALRLYESLGYATTRYNLAKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC82</accession>
    <name>A0A7K2ZC82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000548">
        <property type="protein sequence ID" value="MYW29966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514556.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000548.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="220" mass="24139" checksum="C6E04257B6840A75" modified="2021-04-07" version="1">MANRPVHFIWLLDCSYSMQGEKIGQLNYAIREAVPEMRSVAHDNPAAQLLLRTLTFSTEARWHHKDPVPVDDFTWQDVQVDGMTNLGEALEVVSREFQTPPMPQRALKPVLALVSDGVPTDDWKSGLRALDATPWGKKAVRVAIAIGADADRSVLQEFLGNPELQPLDANSPKQLAAAIRWASTAAVKAASQPVAAPTDATVKQPPYAPPQLDDDDDDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC93</accession>
    <name>A0A7K2ZC93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000547">
        <property type="protein sequence ID" value="MYW29959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="222" mass="24524" checksum="4D34D5C8C4833C17" modified="2021-04-07" version="1">MSGRKPPSARRIADALMEECGRTYAEEAGIRLKDTPQPLYQLLVLSLLLSARIRASVAVAAARALFAHGMRTPRRMVDATWQQRVDALGEGHYRRYDERTATQLGEGAQLVLDTWRGDLRRLREEADGDRDRLMEGLRRVPGIGPARADIFVREVQSLWPETGPWLGAKALQGAERLGLPTSPGKPVQAARGHDDARFAAALVRAALDKDIVDAVTEAARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCF6</accession>
    <name>A0A7K2ZCF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000565">
        <property type="protein sequence ID" value="MYW30047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="18229" checksum="6237E0C033CAB4E1" modified="2021-04-07" version="1" fragment="single">MPPTLASLVQHSALKLTVRAGADRLDTPVRWAHASELADPVPYMDGGELLLVTATNLDAENAESMRRYVRRLAGAGVAGVGFAVGVNYENIPAALLDAAEEAGLPLLEVPRRTPFLAISKAVSAAIAADQYRAVTAGFEAQRELTKAALAGDGPADLLARLAAHIDGWAALYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDE1</accession>
    <name>A0A7K2ZDE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000658">
        <property type="protein sequence ID" value="MYW30364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="12488" checksum="1568517D5EAADCB0" modified="2021-04-07" version="1">MAEERDRDIDVTVGPSGPGCAECLAGEGLGWWVHLRRCAACGHVGCCDSSPSQHASGHAEASGHPVLTSFEPGEDWFYDVRTGAFLDGPALAEPTAHPASQPVPGPAGAVPEDWRELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDJ0</accession>
    <name>A0A7K2ZDJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_14300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="268" mass="29140" checksum="1B83874326C6E254" modified="2021-04-07" version="1">MSSLLLLTNALQPSTEVLPALGLLLHSVRVAPAEGPALVDTPGADVILIDGRRDLPQVRSLCQLLRSTGPGCPLILVVTEGGLAAVTADWGIDDVLLDTAGPAEVEARLRLATGRQQITSDDSPMEIRNGDLSVDEATYSAKLKGRVLDLTFKEFELLKYLAQHPGRVFTRAQLLQEVWGYDYFGGTRTVDVHVRRLRAKLGPEHESLIGTVRNVGYRFVTPEKVERAAEEAKERQAAQQKAAEPVTRSEQSSSATAREEAPVEAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDJ9</accession>
    <name>A0A7K2ZDJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_14360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000668">
        <property type="protein sequence ID" value="MYW30433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="22258" checksum="084D5AF41D9373DD" modified="2021-04-07" version="1">MTTEGSEGSEGRPLRVLLADDEHLIRGALAALLALEDDLVVVAEAASGPEALAMALAHRPDVAVLDLQMPGADGVKVATSLRSELPGCRTMIVTSHGRPGHLKRALAAGVRGFVPKTVSARRLAEIIRTVHAGNRYVDPELAADAISAGDSPLTAREAEVLELAADGAPVAEIAERASLSQGTVRNYLSSAASKIGAENRHTAVRLARERGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDS1</accession>
    <name>A0A7K2ZDS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PrsW family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000695">
        <property type="protein sequence ID" value="MYW30503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="12954" checksum="B33C68A8DD2906CA" modified="2021-04-07" version="1">AGLRRRARHDAVGLDFAARERELLHHLWQRRAIAAPALTHAARMTGRGPRPQPYPYRPPMPPHGQGHGHGYGYGYGYGYGYGYGHGYGQGHGTAYGSPPPQPYPYGRHSQYGPTAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDT4</accession>
    <name>A0A7K2ZDT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000705">
        <property type="protein sequence ID" value="MYW30514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="140" mass="14009" checksum="80FF403920377D9C" modified="2021-04-07" version="1" fragment="single">AADGPGLPFLIGVRHHAPSLAAAVPALLDAAAPDVLLVELPAEFQPWLGWLAHEETRAPVALAAVPADGPGAGGGQGPAFYPFADFSPELAALRWAARNGVPAVACDLPLADRAWAWGGPDAPAPVPGVDSAPVPGEGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDY6</accession>
    <name>A0A7K2ZDY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000716">
        <property type="protein sequence ID" value="MYW30573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="23127" checksum="6A02F03226923C6C" modified="2021-04-07" version="1">MHLALSIAAEEPKGGIAGWATGLVETFGGPGAGLAIALENLFPPLPSEIILPLTGFAASQGVLSLASALFWTTLGSVVGALALYGLGAVFGRERMHALWAKLPLVKPSDLVRTEEWFARHGTKAVLLGRMVPVFRSLISVPAGVERMPLPVFIGLTTAGSLVWNTVLVLAGYWLGDSWDVVGTYVGLMSKVVLGVAVLAVTWWVVTRVRGRKDSRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE88</accession>
    <name>A0A7K2ZE88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_15645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000731">
        <property type="protein sequence ID" value="MYW30673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2132"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1079"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1038"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="2230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="2230" mass="238819" checksum="CC441AB9EC0A172C" modified="2021-04-07" version="1" fragment="single">MSLRALARLYADGEISTAEALAELGRRVDIPLSEGQRGLWALARMEPETYAYNVPLCFSCADVDTEALQAAFRDTLSWHPLLTATVRETDDGPRLSHADADGFSVESVDISDVPSGRVPDLVKERARQPFDLSGEPLTRLAVLRRSPSEAYVLLVVHHLVIDGVSGRLVIDALFRSYRARVEGRDVPMEVGSASFGEFVAWERDVLAGERAEVDREFWVRELAGADVLTGLPTQVALEPDAPHVGEVHTSRLPEERAAAVAAFTASHGISPGIFFLAAFLTLLHRYTGSEDLVIGMPVAGRPTEHFDPVVGCFINTLPVRSRPDASEEFTSFARRVQSTVLDVLEHGTYPFHRIVSDLGARGANPRSPLYQIVYNYQDSALSGYLGERARVTGESDFELVDGLYQLGEYDLTVDVAPGDGFLVNWKYHPDAFSADAVAGMAQHFATLVDSILQSDGQTPTGRLNLLDDEERRLVIEAWNRTEADLPTHRTCWDLFAERAGANPDAPAVTCGERTLTYRELADRSSASAQALTRRGVGPGDVVGVCYERSLDLVVALLAVMRLGAVYLPLDSRLPAERLSYMVEDSGAHLVLCHEAVLDRLAAAQMPEVRLYATDRREEQAAEAAAAVGETASSAPDPRAAYIIYTSGSTGKPKGVVVPHTALTNFLLAMADTLHVTSDDRLLAVTTHSFDIAALELYLPLITGGQVCVADSATAADATLLADKVTDWRPTIMQATPATWAMLVRVGWRNTEGVKVLCGGEALPDGLKDQLVARGEVWNLYGPTETTIWSAAKRLSREEPVTIGSPIANTQLYVLDQNLNPLPVGVTGELHIAGDGVALGYHRKPELTAERFLDNPFAPGRLYRTGDRARRLPNGEIVVLGRIDHQVKLRGHRVELGEIEAVLDAHPAIGRSVVLLGRAGLSDRLTAYYTGNGDAPVDDALLRAELAKTLPAYMLPAAFVALDAFPLTANGKIDRARLTESAQAVPLPAGGNTTADSRVADSLVAALDIERTVRGIFEEVLGSRDIDRGAGFFDIGGDSFAAIEAVARINHEFGCSLRPTSLFAHPSVTAMARHLTGLLPAGEAPEGQPPAEPVRAGRQAAAAQPVEPGPHSDPRPATPAADDATLDDAIAVIGISCRFPGAMDHRAFWSALVEGRSGSTSWSADELRTLGVPEELITRPGYVPQRSVVDGRAEFDASFFDISPRDAEFMDPQARLLLQHAWQALEDAGYRPEDVPGTSVTTSTSTNFYQALLPALMANASGPRVLASSETYAAWLFAQGGTVPTMISTKLGLRGPSMAVSTNCSSALSAVHVACQGLLAGDVDQAIVGAASLFSAGELGYVHQPGLNFSSDGRSRAFADGADGMSGGEGVGVVVLKRAGEAIAAGDHIYCLIRGIAVNNDGGDKAGFYAPSVRGQAEVIRKALDKAGTDPSTISYVEAHGTGTRLGDPIEVAALTEVYRDHTDRRRFCGIGSVKSNIGHLDAAAGIAGLIKVALSLQHGEVPRTLHSDVPSSEIDWDESPFFVADRNLPLDGDGPARAGLSSFGIGGTNAHAVLEQAPTGARAAGRPGPQAVVLSARDGERLGVLTRQLLEFLPGYRDAHGDLASLAYTLQVGRRAMAERVVFVADDLDGLIATLQDYVGRGPRGTVFEGTARRPEDQLLGLFDRPGELRELVAGWLERGEWDKVAPLWVNGIDVDWHARHGANPPVRVSLPTYPFAAKRHWPAAGAVPVARAADQLGAVSVPRATDPLDAASLLAAAAEPESVETFLSGRTSATDELDGLSRPLVLGQLVAGGLFDVPVRRDLMGQGITPSFAQWLDHTVTVLLGHGDLVQEAEFVAPRKSAPGLEQAWRAWRTWKAARADDPELAAKAGLTERMIEALPAILSGRTKATAVMFPGGSFELVEPAYRGNATADFFNDVTAGAVRAEVDARGDGTRMLEIGAGTGSTSERIFARLAGRDVAEYRYTDISKAFLIDAERRMAGQVPYVSFSTFDVEREPGTQGLEPGHYDIVIANNVLHATQDIVRAVRHAGALLRPGGVLVLNELARNDWWSHLTFGLLDGWWRFTDGRRIQGGPALSSDAWREVLRECGFDTVGLLAEPARDLGQQVLLARAGSLVPRRGEQPAPSGSVEEHVRAAVERILAETLKLTDDELAADKPFADYGLDSLTGVSLVQRLNESLGTDLDPSVLFENPSVRRLTSFIVDEEGATVAAGVPLPSVVPERSVVPERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE94</accession>
    <name>A0A7K2ZE94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_15650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000731">
        <property type="protein sequence ID" value="MYW30674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="392" mass="43672" checksum="35D1183E06F87F6D" modified="2021-04-07" version="1">MHLEYTPEQEQLRTELRTYFAALVPDNAYARYAEPAAQKRFYRETVRRLGTDGWLGVGWPKEYGGRGLTPIEQFIFFDEAAQAGVPLPLMALNTVGPTIMQFGTDEQKTYFLPKILAGEIDFAIGYSEPDAGTDLAALKTRAVRDGDAYIVNGQKIWTTNGDTADWVWLAVRTDPDAPPHKGITMLLVPTSDPGYSCTLINTLASHDTTASYYENVRVPLTHRVGEENKGWRLITNQLNHERVTLAAHGTMAVRALHNVQRWAAGTKLTDGRRVIDLPWVRTRLARTHTRLDAMKLLNWQMVSALQNATLTPQDASAVKVYGSEARRDAYAWLMEIVGSSGPLKEGSAGAVLHGELERGYRSAVIFTFGGGNNEIQREIISWIGLGMPRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZED6</accession>
    <name>A0A7K2ZED6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_15675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8099" checksum="C651B661FED84C1E" modified="2021-04-07" version="1">PARFAAPDRFDPLRADADPLLTGPAGCPAALLGRLEAEHGLRALLTAMPGIRWADGFRPASSGVLTRGPRTLLVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZED9</accession>
    <name>A0A7K2ZED9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000731">
        <property type="protein sequence ID" value="MYW30678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6708" checksum="20E0BC2B6DBDC8D4" modified="2021-04-07" version="1" fragment="single">MWKAPAYHTSPGRPDERPHPGQESWCPRSERTPHMSRRHQFYARPLLATAAAVAVLAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEF3</accession>
    <name>A0A7K2ZEF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000736">
        <property type="protein sequence ID" value="MYW30712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="15454" checksum="37AFFD0A5A1EC996" modified="2021-04-07" version="1">MSGTERAGGTERAAASERVGIDELLERVRAGYDRIGPEEAAAAATDGALLVDIRYAALRDRDGLIPGALVVERNELEWRLDPQGSHRAAEAVSHDLPVVVICNEGYASSLAVASLRQLGLHRTTDLIGGFQAWRAAGLPVTPGAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEG9</accession>
    <name>A0A7K2ZEG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000757">
        <property type="protein sequence ID" value="MYW30753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="13"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="26090" checksum="52D67C3BC05AB0C7" modified="2021-04-07" version="1">MIGHDDAMRFLPVGDSMTIGATGDFTWRYRLWQHLEAVCPVSYEIVGPRTTLYDPEANAPLSDAYADPSFPPDARRHLAGWGEGWLHMAPAIADAVRAAEADVLLVSLGLIDLGFYTDAEQTAANARAFIEAARTANPHIRMVLLPVIPNVRAESDAPFAASCARFNELLAKAVADLDTPASPLLLASRPPGYDIHTDTYDGTHPGPTGEHLLAAAFADAMHQAWGLGGPYARQQATPQPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEI0</accession>
    <name>A0A7K2ZEI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="11" type="ORF">GT040_16130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="WWKE01000758">
        <property type="protein sequence ID" value="MYW30764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="558"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="331"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW30764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="584" mass="62722" checksum="3CE6DB760BA8746C" modified="2021-04-07" version="1">MPQLRLALNQIDSTVGDLAGNSEAIVHWTRHAAEQGAHLVAFPEMVLTGYPVEDLALRSSFVEASREALRALAARLDAEGFGELPVVVGYLDRSEHDAARYGQPAGSPRNAAAVLHRGGIALNFAKHHLPNYGVFDEFRYFVPGDSMPVVRVHGIDVALAICEDLWQDGGRVPAARSAGAGLLLSINASPYERDKDDTRLDLVRKRAQEAGCTTAYLAMIGGQDELVFDGDSIVVDKEGEVIARAPQFSEGSVILDLELPAAATVAPSGVVDDGLRIDHVVLSDRPVDAYEPELAGGYAERLDDDEEIYSALVVGLRAYAAKNGFSSVLLGLSGGIDSALCAAIACDALGAENVYGVSMPSKYSSDHSKGDAAELARRTGLNFRTVSIAPMFDAYMEALGLTGLAEENLQARLRGTTLMGISNQEGQIVLAPGNKSELAVGYSTLYGDAVGAYGPIKDVYKSSVFRLAKWRNRAAEERGQTPPIPEASITKPPSAELRPGQVDTDSLPDYDVLDGILELYVDRDQGMDAIVAAGFDAELVAKTLRMVDTAEYKRRQYPPGTKISPKGFGKDRRLPITNRWRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEK7</accession>
    <name>A0A7K2ZEK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000762">
        <property type="protein sequence ID" value="MYW30797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="24496" checksum="9DF284C99EC608E3" modified="2021-04-07" version="1">MTATIPSSDTTKALNATAKDIEAKARKYSKSTLCWRSFIRPTWAGIPKELARLSGYKYAGDARGFSAKQKNPGSRAGVTGTVNWKSGRGTWDRFTGKTRVYKTPNSRLVATPKASVKKIKFKALNKHNGKERGVRIIIDATGPFCPKTGAKRAGIGSSATVQMTRGGSFHVTGKHRQAPDHELYVYNYAGKKYKAKTILRDKMLDLWCISQPACRLQNIAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEM8</accession>
    <name>A0A7K2ZEM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_16105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000757">
        <property type="protein sequence ID" value="MYW30759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="687"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="770" mass="82275" checksum="0D2F9D6EFEEFAE82" modified="2021-04-07" version="1">MGLLPPYLDPALPVADRVADLLGRMTLPEKVGQMLQLNAKEGVRHLVEELHAGSILHASPERVLEAAALTEKTRLRIPLLVAEDCIHGHSFWEGATIYPTQLGMAATWDTDLVERIARATAVEVAATGVHWTFSPVLCITRDLRWGRVSETFGEDPFLIGELGSAMVRGYQGEGLTDPTAILACAKHFAGYSETQGGRDASEADISRRKLRSWFLPPFERVAKEGCRTFMLGYQSMDGVPITVNDWLLGEVLRGEWGYTGTLVTDWDNVGRMVWEQQIYADYAQASAAAVRAGNDMVMTTSKFFEGAQEAVAEGALTEAEIDAAVRRILTLKFELGLFENPRHPDAARQAEFIGSAAHAELNLEAARRSLVLLTNDGTLPLAGGLEAEEPGSLTAHGGGRARATGSGPRTVAVVGPNAHDAQTQLGDWAGSSGQADWLPDGQPRAMIRTVLDGFRDRVPADWTVAYAPGARILGVGPDPEGEFFPDGQPRPEVVVPAEPDPGLIAEAVAAAEAADHVVAVVGDRIELIGEGKSTATLELVGDQVALLDELAATGKPLVVVVISSKPLVLPPSALGAAAIVYAANPGMLGGTAVAELLLGLIEPTGRLPLSFARHAGQQPTYYNQVRGQHGTRYADLTQSPAFAFGEGLSYTTVEYTDLELLTAVVEPTETVRARVTLTNSGARPALETLQVYVSDTVTSVTWAEKELKAYEQVALAVGESRQVSIELPVAACTLVDAQGRRVVEPGRFELLVGPSSRDEALLRAEFTVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEP1</accession>
    <name>A0A7K2ZEP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">DNA ligase</fullName>
            <ecNumber evidence="9 10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">ligA</name>
        <name evidence="13" type="ORF">GT040_16450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9 10"/>
    <dbReference type="EMBL" id="WWKE01000766">
        <property type="protein sequence ID" value="MYW30823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="639"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="729"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="45"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW30823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="755" mass="82552" checksum="8C395CA81965FAFB" modified="2021-04-07" version="1">MAGEERVEQESSVPADAREEHALLAERIEEHRFRYYVKDQPVVSDADFDRQMRELEALEDEYPPLRTPDSPTQKVAGPYRTEFTSVEHAERMLSLDNAFDDEELAAWAERVAKDVGTPDHHFLCELKVDGLAVNLTYEHGRLTRAATRGDGRTGEDITPNVRTIAEIPHRLQGDDIPALVEIRGEVFFPMEAFEELNARLVAADDKPFANPRNAAAGSLRQKDPKVTATRPLHMVVHGIGAHEGLTLDRLSQAYELLHTWGLPTAKHNKVVDSLAGVREFIAYFGEHRHSVEHEIDGVVVKLDEIPLQGRLGSTSRAPRWAIAWKYAPEEVNTKLVNIRVGVGRTGRVTPYAQVEPVEVAGSEVEFATLHNQEVVKAKGVLIGDTVVIRKAGDVIPEILGPVVDLRDGTEKAFEMPTHCPECGTELRAMKEADIDLRCPNARTCPAQLRERVFYLAGRKSLDIDHFGYVAAAALTRPLEPAEPVLKDESGLFDLTIEQLLPIRAYVLDQDSGLPKRDPKTGEEKIATVFANKQGEAKKNAVAMLEGIAAAKEAPLARILTGLSIRHVGPVAAQELARQFRSIDRIDEATEQELADADGVGPIIAASVKQWFAEDWHREILRKWREAGVRMADEGSDEEQGPRPLEGLTVVVTGTLTAYTRDGAKEALQSLGAKVTGSVSKKTAFVVVGDNPGSKYDKAMQLKVPVLDEAGFAVLLEQGPGAAREAALPVPEAAASVAAPEATPEADAEAPEAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEZ9</accession>
    <name>A0A7K2ZEZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_16800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000778">
        <property type="protein sequence ID" value="MYW30888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="98"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="459" mass="50167" checksum="DA6C5898085C8618" modified="2021-04-07" version="1">MDGTQGARGADQTHTTPGTPATSGTPAAHSERGTGSSYGPADTERFDTEQDKRPGRTAFQRDRARVLHSAALRRLAGKTQVVTPGTRSLVWDASPRTRLTHSLECAQVGRELGAVLGCDPDLVETACLSHDMGHPPFGHNGEQALNDFASDCGGFEGNAQSLRLLTRLEPKRFVHDPRTGELVSVGLNLTRAALDAATKYPWPRGAHPTDPHSVKFGVYADDLPVFEWARKGAPEGRTCFEAQVMDWSDDVAYSVHDFEDGLHAGHIDPNCLYAEPEREEIFAVAIGRYVPVDTDPQELAEALDRLIDQEWWPHGYDGSAVAQARLKDATSQLIGRFCTEAETATRELYGPGRLTRYGAELVVPRTVRNECAVLKAVADRYVMQRAEQETLRADQRIVIAELAAALTARAPEGLEPHFRALFDQAPDDHSRKRVLVDQIAALTDASARSLHAALTARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF43</accession>
    <name>A0A7K2ZF43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000806">
        <property type="protein sequence ID" value="MYW30952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="13040" checksum="16E9C46E41B94B2E" modified="2021-04-07" version="1">RSDAHLAATGERPKVFIAALGPAAAHTARASFAVNLFGAGGIEAVHRPVSVDAATAGEALTASGASVACLCSSDALYAEQTAEVAGALKSAGAAQVFLAGRPGEYADVDSYVFAGCDTVAVLTSVLDRMGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFU1</accession>
    <name>A0A7K2ZFU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000866">
        <property type="protein sequence ID" value="MYW31223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="209"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="411" mass="43501" checksum="575E4326EDBF06C0" modified="2021-04-07" version="1">MKSRASRPEDLVDQPGGGGLPGRLGDELRAELIAFRRDLHMHPELGNQEFRTTAAIKDRLEKAGLKPRVLDVGTGLVCDVGEWDGVTPMLALRADIDALPIPDTKVDVPYRSTVPDRAHACGHDVHTTTVLGAGLVLAALDRQGLLPNAVRLVFQPAEEVMPGGALSAIKSGVLEGVGRIIAVHCDPKVDVGTIGLRIGPITSACDRLEISLDGPGGHTARPHLTTDLVTAAARVAVDVPALLSRRVDARSGLVLTWGRLHTGHAPNVVPQHAELSGTVRCLDLNAWRDAADLVHAAVDEVAGMHRAKSVINYVRGVPPVVNDAESVGLLDAAMTERRGSYAIEDTEQSLGGEDFSWYLEQVPGAMARLGVRPPGDTRGLDLHRGNFDVDEEAITVGVELFTAAALLAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFZ6</accession>
    <name>A0A7K2ZFZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000877">
        <property type="protein sequence ID" value="MYW31283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="167" mass="18712" checksum="8F4D7AAF36FFD22F" modified="2021-04-07" version="1">MPARVRVEDRECPLSTAMSYVGEWWTVLLLHDCFDGYTRFDQFEANIGLSSSMLTTRLKTLVDNGILTKRVYQERPVRHEYVLTDFGRSLRPVLVAMAAWRNEQLAPSERAMVLVDTDTGREVEPVTVDPVTGLSVSDPRFAFRSGPAAGEEMRARYAGERGKPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGB3</accession>
    <name>A0A7K2ZGB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000900">
        <property type="protein sequence ID" value="MYW31339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="14869" checksum="25D413A5AF2ACCBF" modified="2021-04-07" version="1" fragment="single">KQGFGKHRRSHEAKLSGRVRAARTRLEALRRTPVPAPPKPLAFTGRPALAGETPSGFLVELEDVSVGERLHLPALRVEAGARLLVTGDNGAGKTTLLRVLAGDLAPDTGTVRRRARVGYLPQELPARPTRRTLLATFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGB6</accession>
    <name>A0A7K2ZGB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000909">
        <property type="protein sequence ID" value="MYW31382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="7"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="34324" checksum="0665B42C05CD11A9" modified="2021-04-07" version="1">MRAAIVEAPGKVSVTTVDDPTPGRRDVVVKVASCGLCGTDLHILQGEFAPTLPIVPGHEFAGEIVAVGTDVTELAVGDKVAVDPSLHCHECRYCRSGRGNLCDNWAAIGVTVPGGAAEFAVAPVANCVKLPEHVDVTDAALIEPLSCAVRGYDVLKGNLGAEVLIYGSGTMGLMMLELAKRTGAASVDVLDINAQRLETAKLLGCTGAAARAEELDRPGGWDVVIDATGNAGAIQDGLGRVAKGGTFLQFGVADYATTAVIEPYRIYNQEITITGSMAVLHSYERAAALFASGVLDPAVFISDRLPLEQYPQAIDQFKAGVGRKIVVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGD5</accession>
    <name>A0A7K2ZGD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetate-CoA oxygenase subunit PaaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">paaC</name>
        <name evidence="1" type="ORF">GT040_19505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000911">
        <property type="protein sequence ID" value="MYW31400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011882">
        <property type="entry name" value="PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037834">
        <property type="entry name" value="PA_CoA_Oase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02158">
        <property type="entry name" value="PA_CoA_Oxy3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="25976" checksum="7C3990176C2DD9A9" modified="2021-04-07" version="1">MSAALALGDDALVLSHRLGEWAGHAPVLEEEVALANIALDLLGQARVLLSLVGDEDELAYLREERAFRNLQLVEQPNGDFAHTIARQLYFSVYQHLLYERLAAGGGEFADLAAKAVKEVAYHRDHAEQWTLRLGDGTAESHERMQAGLEALWRFTGEMFQPVEGLDATGSGVDPEELESAWLSAVTGTVERATLTLPTGPRTGAWTAGAGRQGVHTESFGRMLAEMQHLHRSHPGASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGD7</accession>
    <name>A0A7K2ZGD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="17103" checksum="44FC8E807287067B" modified="2021-04-07" version="1">MKLAEALAERAEATRRVEQLRARIVSSARYQEGETPAEDAAQLLAEAGEVLSALEALIRRINRTNAAVEMGPDGTLTDALARRDVLRLRHSVVTAAADAAAGSSERGYGRQLRSELMMLSALPVAELRGQADVLAREIREVDVRIQRTNWEVDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGJ1</accession>
    <name>A0A7K2ZGJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000918">
        <property type="protein sequence ID" value="MYW31438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="25154" checksum="7BDE1A5A902BE597" modified="2021-04-07" version="1">MLEAMIPRPGLHVIFDLDGTLVDSEPNYFEAGRRLLARYGVSDFRWEDHTRFIGIGTRETLTTLRAEYGIDAPVDELLAGKNALYLELAGASTEVFGQMRAFVELLHAAGVPMAVASGSSRAAIGAVLAVTGLEAYIPLYVSAEEVAHGKPEPDVFLETARRMGVEPADCVVVEDAPPGAAAAHAAGMRCIAVPYAPATASDPAFKAADLLFTGGQSAFTAEAAYGWLRGETRPGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGV0</accession>
    <name>A0A7K2ZGV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000965">
        <property type="protein sequence ID" value="MYW31570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13619" checksum="8887DC1075DB1A64" modified="2021-04-07" version="1" fragment="single">MSKTYAGARLRRLREERGLSQAELARMLAISPSYLNQMEHDSRPLTVPVLLRLTEAFGVDPGFFSERDTTRVLADLREALADEVGAARVSAAELSELASRLPGVASVLLDLGRRNQALAGRLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGW6</accession>
    <name>A0A7K2ZGW6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">fdhD</name>
        <name evidence="4" type="ORF">GT040_20560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000970">
        <property type="protein sequence ID" value="MYW31603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="29498" checksum="BA7A904AAB575BB3" modified="2021-04-07" version="1">MGRVTERRRTLRIRDGAVSSRADTLVAEEPLEIRLNGKPLAITMRTPGDDFALAAGFLVSEGVIAEGDEVQSIVYCAGATADGVNTYNVVDVKLAPGVVVPDITLERNVYTTSSCGLCGKASLDAVRTTTRHPVGDTPPVRVTPELLSALPDRLRAAQKVFDRTGGLHAAALFSEEGELWDVREDVGRHNAVDKLVGRALTDGRLPLSRAVLLVSGRASFELAQKAVMAGIPVLAAVSAPSSLAVDLAAESGLTLVGFLRGPSMNVYAGEHRIALEAGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH78</accession>
    <name>A0A7K2ZH78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000995">
        <property type="protein sequence ID" value="MYW31706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14507" checksum="66278A99341F397D" modified="2021-04-07" version="1">MNRPNLTHPDPRPTLAPAPALAPPRQLPRRPLDLRVRTRRIQVEELVVDDPGKVLDHAQRAALTAPDTAAVLGHSPTTPLTLPAAAALLCALHEPGELAAMGLRLTRHTTHVTASDQQTEPVSLELSYAPDGPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH97</accession>
    <name>A0A7K2ZH97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001000">
        <property type="protein sequence ID" value="MYW31714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="5830" checksum="193969E5C87A2C40" modified="2021-04-07" version="1" fragment="single">MKAHDQMYISGAWRPAVGQDTIAVVNPADEQLIGHVPAGTAEDVDAAVKAARAAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHJ0</accession>
    <name>A0A7K2ZHJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001021">
        <property type="protein sequence ID" value="MYW31822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046245">
        <property type="entry name" value="DUF6278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19794">
        <property type="entry name" value="DUF6278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15763" checksum="67B69790278D6FBA" modified="2021-04-07" version="1">MNIPFLDNWRKRQGSTQGHALAAAVEADPDGVAELLAECELLRARAGQQGLELDDSPASLSALDQLPPRWRDDPEELPWLGNDAGLYLGTVIVRTVTGAAWDIWPSGQPVVRLESGREIDVVAAGLDWAMTGSPELSQVYAESAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHM9</accession>
    <name>A0A7K2ZHM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001031">
        <property type="protein sequence ID" value="MYW31861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="19989" checksum="6F1886AB9E1BA46D" modified="2021-04-07" version="1">DGWREFRARSWLWGVIAVWTVYGFAVLGPVLPLTAVLVTQAHGSGAYGMLMAVNGAGSVVGGLMALRLRPSRPLAAGAIALPLVAVSLVVLALGMPLPVLAAGQLLAGAAAAFWLVMWSTTVQTHVPPEALNRLHAYDVAGSLLMVAAGRALAGPVAEAVGAPELLVAAAVVNMGVVAVLLVARPIRQLKRRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI31</accession>
    <name>A0A7K2ZI31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001066">
        <property type="protein sequence ID" value="MYW32020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="127" mass="14488" checksum="B98753BCC251FD47" modified="2021-04-07" version="1" fragment="single">MNAALRSAMEDAKLTPRKLATRIGVAPKTVERWLADAELLPHARNRVDACRALKVDEDMIWPKVVQERVKTGHDRELAHAYPYRSACPSTVWSELIAGASTDIFFAGYTNYFVWLEQPAFIETLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIA0</accession>
    <name>A0A7K2ZIA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001072">
        <property type="protein sequence ID" value="MYW32045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="297" mass="31724" checksum="1FA72F35A60D92A7" modified="2021-04-07" version="1">MGAAPSPPAEAVGLLKGRIGEPVTTRLLSDRRGSRAWRIEGTQGVVALKANDPDAETARDKAAEMAQEGDHLIRLTEAGALSPGYRVGAGAWEGGRWLAVRWVDGIPVWGAFAPAREPEGGRPSMRPWLLGITRTWAERLAQLHTAGWAHADVQPTNTLITQAGAAEVIDYALACGPDGRPRLPFRGALTHTTSPEIADAILATAADTHIQAEPPADIWGLGASLFWCWTGHRPVPYDDDTPRVDKLKAIARAATLPLDGARPWTFAEFEKVIRACLAPAPEDRPSATDLAALLTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIC5</accession>
    <name>A0A7K2ZIC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001065">
        <property type="protein sequence ID" value="MYW31999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="54" mass="5844" checksum="231E81BAE294DC83" modified="2021-04-07" version="1">MGSHSGFRTGNRYDARMVPHDVSNRTPGTLLVARLHVDLCRLKSAICPPPAACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIC9</accession>
    <name>A0A7K2ZIC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_23185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001085">
        <property type="protein sequence ID" value="MYW32097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="249" mass="28063" checksum="695E8A5E58E07FE3" modified="2021-04-07" version="1">MEWSIQEIARKAGTTSRTLRHYGDLGLLAPSRLGSNGYRYYDQDALVRLQRILLLRELGLSLPAIKGLLEGQRDTAVALRAHLRLLEQEQARIGRQIASVRTTLHKTEEGRELMAEEVFDGFDHTAHEREVTERWGREAYEEGDRWWRSLGEAGKQAFLGEHEAIARDWGSAREAGADAGGERAQDIARRHCAWLSASSGEPGRSYVIGLGEMYVADPRFGKNYDRYGDGTAAFVRDALTIYAERRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZID0</accession>
    <name>A0A7K2ZID0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001093">
        <property type="protein sequence ID" value="MYW32112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="12356" checksum="1157777AE5054A08" modified="2021-04-07" version="1" fragment="single">MENTPLAPPHAPAPAAARGRVLVVDDDPTVAEVVVGYLHRAGYAVERAGDGPAALERFAAARPDLVVLDLMLPAMDGFEVCRRMRAHGPVPVIMLTARGDEEDRILGLETGADDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIE4</accession>
    <name>A0A7K2ZIE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001068">
        <property type="protein sequence ID" value="MYW32029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="31112" checksum="5BE5CF8639A64479" modified="2021-04-07" version="1">MTAPAGPRRPALLLVTDLAYEARGRRYCDEDIFLASRLREAFDVALCHPRDAAALLDRFDLALVRNSGPVLHYREAYDAFRARALELGVPVCNPLDGRGDMAGKEYLVELSRAGFPVIPTVDRAADLGLLPEAGAYVVKPKLGADSVGLRFVGGAEVAGELAEEGEGALLVQPRVDFRYEVSFYFVDHDFQYALYAPDPERRWVLEPYAASAGDLAFARRFIEWNALGHGIQRVDACRTAEGELLLVELEDLNPYLSLDRVDEEVREAFVARLKASIASLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIN4</accession>
    <name>A0A7K2ZIN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">manA</name>
        <name evidence="8" type="ORF">GT040_23830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001113">
        <property type="protein sequence ID" value="MYW32216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="408" mass="42791" checksum="999BEB16E43FB538" modified="2021-04-07" version="1">MDRLSNTVRPYAWGSTTAIPALLGTAPTGEPQAEMWMGAHPGAPSRIARPKSATYTTGTTETTATQTERPLTEVIAADPEGELGAATVARFGPRLPFLLKLLAAGSPLSLQVHPDLDQARKGYADEEARGIPIDAPHRTYKDANHKPELICALTPFDGLCGFRRPTEAADAMEALGVDSLKPYVDLLRAHPEEAALREVLTAILGADPAEMADTVAEAAAACERLGGAHAPYARIAHNYPGDPGVLAAMLLNYVQLQPGEALFLGAGVPHAYLDGLGVEIMANSDNVLRCGLTPKHIDVPELLRIVRFEATEPGVLRPEASPSGEERYETPVDEFALSRYTLASGAAPAGLTAPTPQILLCTAGTVRVGEIDLTPGQSVYVPAAEAVEATGSGTLFRATVAAGTVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIR3</accession>
    <name>A0A7K2ZIR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001117">
        <property type="protein sequence ID" value="MYW32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029781936" evidence="1">
        <location>
            <begin position="33"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="393" mass="42040" checksum="4651AF08F6187519" modified="2021-04-07" version="1">MVRTKTAGKLRKGMLVIAAASLVASATTVAAAANPPQDAPGRSGTDRALQKSLDSLVREHEFPAAFAWVRKDGRTSSLVSGTARLGKQVPVPRDGYVRAGSNTKTFTAVVVLQLVAEGEVALDEPIETYLPGVVRGEGIDGRKITVRQLLQHTSGLPNYTEHIGLEDFAKLQHKFFQPHDLLAAALAHPAEFAPGARWKYSNTNYLLAGMLIEKVTERPVQEQITERVIRKAGLRHTSWPQPGDQSLPRPHARGYALSSTENGKVVDATRMDPSWGGAAGQMISTPSDLAKFARLLLDGKLLAPEQLAEMRTTVDAPLMPGWRYGLGVFSIPLSCGGEYWGHGGDIDGYETRGGATDDGRSVGLAVTALPGTFSDAEKSAKAVMSATDTAFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ75</accession>
    <name>A0A7K2ZJ75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001140">
        <property type="protein sequence ID" value="MYW32309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="78"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="27513" checksum="ADC4CB071E4A8800" modified="2021-04-07" version="1" fragment="single">ITVLDEADQMADMGFMPQVTELLDQVNPEGQRMLFSATLDRNVDLLVKRYLNDPVVHSVDPAAGAVTTMEHHVLYVQGADKYATTTEIAARDGRVIMFLDTKHAVDKLTDHLLHSGVRAAALHGGKSQPQRTRTLERFKTGHVTVLVATNVAARGIHVDNLDLVVNVDPPSDHKDYLHRGGRTARAGESGSVVTLVLPNQRREMTRLMADAGITPQIAQVRSGEAELSRITGAQAPSGVPVVITSPPKERSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJC1</accession>
    <name>A0A7K2ZJC1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001169">
        <property type="protein sequence ID" value="MYW32435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14394" checksum="B040D0D5CC5AF689" modified="2021-04-07" version="1">MKYLVMVQGSQADYDAQAGKGSADSPAWDEKAMQEMFAHMGSINDDLAESGELVTAYGLTEPAQGRAVSLDAEGRPVVSDGPYSETKELLAGFWILECESLERVTEIAARVARCPQPAGAPEYPVLIRTIGGGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJE6</accession>
    <name>A0A7K2ZJE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_24695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001154">
        <property type="protein sequence ID" value="MYW32379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073873626.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001154.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="124"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="354" mass="38825" checksum="BD3DB03360148B7D" modified="2021-04-07" version="1">MTQTPTQPQARAQIRIPAAHPMVMLLGSGDSLLRVIEEAFPAADIHVRGNEISATGEAADVALIQRLFDEMMLVLRTGAPMTEDAVERSIAMLRAAGTGEGDPQGETPAEVLTQNILSNRGRTIRPKTLNQKRYVDAIDQHTIVFGIGPAGTGKTYLAMAKAVQALQAKQVSRIILTRPAVEAGERLGFLPGTLFDKIDPYLRPLYDALHDMLDPDSIPRLMAAGTIEVAPLAYMRGRTLNDAFIILDEAQNTSAEQMKMFLTRLGFDSKIVITGDITQVDLPSGTKSGLRQVQDILEGLDDVHFSRLTSQDVVRHKLVGRIVDAYEKYDSRNGQQDGQADGREDGRRDRRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJE9</accession>
    <name>A0A7K2ZJE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001181">
        <property type="protein sequence ID" value="MYW32468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="6334" checksum="1ACC0731B1D426FD" modified="2021-04-07" version="1">MSNTAAGLPEEPEGRLDAEQPKRSRELPVFDSGRPLAPDEMNESVYEHIKKRAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJG6</accession>
    <name>A0A7K2ZJG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_24795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001158">
        <property type="protein sequence ID" value="MYW32399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="45"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="207"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="389" mass="42012" checksum="5F039C0A1B413DCE" modified="2021-04-07" version="1">MPQHVPPPLLPAAAPQGQGQVSPRVSASPRRIVFLAHRDLGNPAAGGSELLIDQLALGLTERGHDVTLLCGGQAARRPYRVVSAGSQLGHYLGARSAFARQVGSCDLLIEVCNGMPYLAPLWHRGPTVCLVNHVHTDLWEMRFPAPVARAGRQLEHWALSRAYRDHLMIAVSPSTAGALRELGVPDERIRLVNNGVQDPLPQSERSATPLFLALGRLVDYKRIDLLLQLWERVRPVTGGRLVIVGDGPEREKLEKLAGPDVEFAGHVSEAEKHRLLCASWMLLHPAAVEGWGLVVTEAGTRSTPTLGFDVPGLRDSVEDGVTGILARGESSFAAAWCALALDEERREAMGKAARERAAAYRWSSSVTQLEAVAAEAISGTRSWPTGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJH5</accession>
    <name>A0A7K2ZJH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001161">
        <property type="protein sequence ID" value="MYW32409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11015" checksum="0E2F4BCD4E0311E1" modified="2021-04-07" version="1" fragment="single">MTFRATARHPALILDDVRGAQKMLSGVARVTALEGSRHLSELVGAPVHLKCENLQRTGSFKLRGAYVRISGLSPVERAAGVVAASAGNHAQGVALASSLLGVRSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJK0</accession>
    <name>A0A7K2ZJK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK family alpha-L-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="101"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="292" mass="31302" checksum="92DA77B37C52501C" modified="2021-04-07" version="1">MSTTPEQPGEGGIAVLASRIGADEKRLFDAFDRRGIPFDHLDTRGQWFSAEQRQPPRRIVLNREIGQFRAAYAARSLTEAGAEVVNSADAIEVCGDKWRTTMALQAAGIPTPRTALGLTPKATLAALDSIGYPALIKPLVGSWGRLVVRLPDRAGAEGVLEYVTALPGPQSHLGYVQELIDKPGRDIRAIVVGGELLGAVYRTGELWRTNVALGAQTLPCEATPEITKLSVAAAAAVGADIAGVDLIEDADGRLLVLEVNHRVEFTGFQSALGDQVDVADRIVEHLQERAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJN5</accession>
    <name>A0A7K2ZJN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_25550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="34857" checksum="D1CBC5508A74E1EE" modified="2021-04-07" version="1">MTGQMSRTKDASDHRPKTPPDHVRAVPVRRPGRWIAVLVIGVLIAQFLHLVLTNQNLHWDVVGQVFTYRTVVRGLSFTLLLTVLAMMIGIVGGVLLAVMRLSNNPVLSGVSWVYVWVFRGTPVLVQLFFWNFLGAIIPDIGLGIPFGTTFVEWSYNDLVGLFTAATLCLGLNEAAYFSEIVRAGTLSVDEGQSEAAASLGMTRSQTLRRIVLPQAMRVIIPPTGNQTISMLKTTALVSAISLEELTRAALDIGNRTLYVIPALIAASLWYLAFTSILSIGQYYIERHFARGSNRTLPLTPIQRARARLGVPSKGKGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJN7</accession>
    <name>A0A7K2ZJN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="66"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="139" mass="14552" checksum="D112EB4B616F644A" modified="2021-04-07" version="1">MPSYSIGQAAELLAVSPETVRRWADGGHLAMDRGSSGNRLIDGVSLAAFATERATGLHPVPGGGALTSVRNAFAGIVTAVIMDDIVAQVEIQSGPHRLVSLISRESVDELGLEVGVLATARVKSTNVHIDRPGSQSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKC7</accession>
    <name>A0A7K2ZKC7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pstA</name>
        <name evidence="10" type="ORF">GT040_26895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001253">
        <property type="protein sequence ID" value="MYW32802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="146"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="362" mass="38194" checksum="48A6FD290F11639F" modified="2021-04-07" version="1">MTHASTAVQERPTPPGGPGAPKSGLSSRSLPRLAPVGFAALAIALSVGISTAAGWHSKVQWGMIAALLFLAISYVATTVVENKRQAKDRLATSVVWVCFLIAIVPLASLLWTTITRGAERLDGYFLTHSMAGVLGSEASGGVYHALIGTLEQVGIATVISAPLGLLTAVYLVEYGKGSLAKAVTFFVDVMTGIPSIVAGLFILSIMLIFEIQPSGLMGALALTILMIPVVVRSTEEMLKLVPNELREASLALGIPKWRTILKVVLPTAIGGITTGVMLAIARIAGETAPIILLVFGSQLINTNPFSGAQSSLPFYIYEQYKIGEAASYDRAWAAALVLIAFVMILNLVARGIARWKAPKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKH5</accession>
    <name>A0A7K2ZKH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001261">
        <property type="protein sequence ID" value="MYW32841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="29536" checksum="FF2FA5506B4AB2B1" modified="2021-04-07" version="1">MAGADADDDALLVLTAVLLTPARFPSVLGDDYVAACEALALEPYEEGYGLVLGQDGDGARWTVVVEDVSLVAVAIAAWDCGMEYDLSPDDRSVVCALPGWPLALAVAAPGVPAPHDPETGGVGPAPLSPPDTGSWGPAQRRLGADEIAERWALWREQIDDAQFVRPGGEQAGQAGNGEQGDEDTAAEGDAEPVGAATGQHPGVRRALAEALAYTKAPPPPGRIRSGFASADARTLRVDGPGWSMVARTDDIALILLDEEPGEVLPVGRGPALPGLLKALDALAPHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKS6</accession>
    <name>A0A7K2ZKS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">clpB</name>
        <name evidence="14" type="ORF">GT040_27630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001297">
        <property type="protein sequence ID" value="MYW32943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="403"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW32943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="879" mass="97950" checksum="4A39B2138B74CC18" modified="2021-04-07" version="1">MDMNRLTQKSQEALQEAQSAAGRMGHTEVDGEHLLLALVDQEDGLISRLLEQAGSDPAELRAAVREELSRRPKATGSGAAPGQVFVTQRLAGLLDAAEREARRLKDEYVSVEHLLLALAEEGASTAAGRLLNRAGITRDSFLGALTQVRGNQRVTSANPEVAYEALEKYGRDLVAEAKEGRLDPVIGRDAEIRRVTQILSRKSKNNPVLIGDPGVGKTAIIEGLAQRIVRGDVPEGLRDKIVFALDMGSLVAGAKYRGEFEERLKAVLSEVKAAQGGILLFVDELHTVVGAGAAEGAMDAGNMLKPMLARGELHMIGATTLDEYRKHIEKDAALERRFQQVLVGEPSVEDTISILRGLRERLEVFHGVKIQDTALVSAATLSHRYITDRFLPDKAIDLVDEACARLRTEIDSMPAELDELTRRVTRLEIEEAALSKETDPASQARLEELRKELADLRGEADAKHAQWEAERQAIRRVQELRQELEQVRHEAEQAERAYDLNRAAELRYGRLQDLERRLAAEEEQLATRQGQNRLLREVVTEEEIAEIVAAWTGIPVARLQEGERDKLLRLDEILRERVVGQDEAVRLVADAIIRARSGIRDPRRPIGSFIFLGPTGVGKTELTKTLARALFDSEDNMVRLDMSEYQERHTVSRLMGAPPGYVGYEEGGQLTEAVRRKPYSVVLFDEIEKAHSDVFNTLLQILDDGRITDAQGRTVNFRNTVIIMTSNIGSEHLLDGATAEGEIKPDARALVMGELRGHFRPEFLNRVDDIVLFKPLGERQIERIVELQFDELRQRLAERRIDVELTDAAREVISHQGYDPVYGARPLRRYISHEVETLVGRALLRGDVQDGATVRVDAEHGELVVTYDQPEEAREARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKV8</accession>
    <name>A0A7K2ZKV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001299">
        <property type="protein sequence ID" value="MYW32970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="233"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="626" mass="68664" checksum="446E0D3574D61D21" modified="2021-04-07" version="1">MGISTRSTVGGTVRSEGYDYDTYSRLAGPLTEPDPEGYRVRYRSLLSSEKHRIRAVLLMTLAPVLTATLMLYLVWPSHWTDRENGERWLVVADTAMLVSIGLIGLFMLVNVVSIAHATMVARDPVPVTPEPGTRVAFLTTYVPGKEPLSMVRATLKGAVRLTHSGPLDIWLLDEGDDPAARMLCAELGVHHFTRRGVPEWNRKKGVHKAKTKHGNYNAWIALHGDDYDFFASVDTDHVPMPNFLERMLGYFRDPDVAFVVGPQVYGNYDSAVTKAAESQQFLFHALIQRAGNRYGAPMFVGTNNVVRVAAVRQAGGLYDSITEDMATGFEIHRRRNPLTGRFWRSVYTPDVLAVGEGPASWTDFFTQQLRWSRGTYETLFKQYGKALFRVPPGRLLSYTLMLVYYPMTAVNWLLGVFSCVLFLWFGASGTQVAASIWLMLYSDAAALQIGLYLWNRRHNVSPHEPEGSGGLAGMAMSALSAPIYLKSLGSAVLRTEGRFVVTPKGGQVSPDRLLTFRIHLAWAAVLVSSLAASVYLDHTHVAMRTWATLGLAIALSPVAVWAWTQWQDRRTRAGNAVPALAPAPAPAAAPAPVQQVLPEPTYLTTTTTTSSSASAGTTATTTAGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL95</accession>
    <name>A0A7K2ZL95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001333">
        <property type="protein sequence ID" value="MYW33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="1">
        <location>
            <begin position="47"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="33026" checksum="E1D4D6E8C336C040" modified="2021-04-07" version="1">DVHAETSGVAHFAYDDEETCIAEVRYLIGMLPSNNRENPPAVESDDPADRRGDVLLDLVPADGNRPYDMHQVIEELVDDGDYLEIHERWARNIICALARLDGQVVGIVANQPQALAGVLDIEASEKAARFVQMCDAFNIPIITLLDVPGFLPGVDQEHGGIIRHGAKLLYAYCNATVPRISLILRKAYGGAYIVMDSQSIGADLTYAWPTNEIAVMGAEGAANVIFRRQIADAEDPEAMRARMVKEYKAELMHPYYAAERGLVDDVIDPAETREVLIASLAMLRTKHADLPSRKHGNPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLC7</accession>
    <name>A0A7K2ZLC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001347">
        <property type="protein sequence ID" value="MYW33164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="25846" checksum="F4446F6068A9BD8E" modified="2021-04-07" version="1" fragment="single">LLVVGEVITDIVARHGSPLVHGTDTAAHIRSVPGGAGANVACWAVRSGCLDVALVARAGAESADWHREALEQAGVRALLAVDPEVATSTVIALVDAAAERTFLTDSGAVLRLATEDFAPPMLDGVGRLHLSGYLLFAAASRGAALLALRTAMERGVPVSVDPASAGFLAELGPKRFLELADGAELLLPNADEARLLTGLPEPEEAAAELSRTFPRVAVTLGERGAVVAAGGVVTARVRARPVPHPVDSTGAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLH6</accession>
    <name>A0A7K2ZLH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">pheS</name>
        <name evidence="15" type="ORF">GT040_29020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="WWKE01001351">
        <property type="protein sequence ID" value="MYW33201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="135"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW33201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="379" mass="41576" checksum="3FB8E70266DB6FE0" modified="2021-04-07" version="1">MSAPNKSYDPVEVEALKPEEIERMRDEAFAAFAAAGDLDALAQAKTAHTGGTSPLSLANREIGALPPQAKAEAGKRVGQARGAVSKALAARQSELEAERDARVLVEEAVDVTLPYDRVPAGARHPLTTFMERVADVFVAMGYEIAEGPEVEAEWFNFDALNFVPDHPARQMQDTFFVQGTTPDGKATEGDESGVVLRTHTSPVQARSLLERKPPVYVVCPGRVYRTDELDATHTPVFHQIELLAVDEGLTMADLKGTLDHMVQALFGPDMKTRLRPNFFPFTEPSAEMDMVCYVCRGESVGNPDRPCRTCGSEGWIELGGCGMVNPKVLTACGVDPQKYSGFAFGFGIERMLMFRHNVEDMRDMVEGDVRFTRPFGMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLT0</accession>
    <name>A0A7K2ZLT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001370">
        <property type="protein sequence ID" value="MYW33313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="284" mass="31988" checksum="7C218DAABBA0EC91" modified="2021-04-07" version="1">MVDEGEGARARGAGYAGLAAVGPYGVRPGHALITMVEPHPGHEYAYNRWYEDDHYYAGATAMPWMFAGRRWVATKDLQELRYPEESAVARPVGTGCYLSTYWVTEGRYDEHMKWTVAINKRLNRDGRVYQDRTHVFTAFQDHEATVYRDGAAGPRDFHALDHPYAGLVLQVVDAEGPEQRAELLEWLRSRHLPKRLSGSPAAMVTVFRPTPLPGDRMTYVKQVEGVDTRLTLLWFLQEDPRTCWGAHFTGLDAAVAEAGLGRVELVAPFIPTVPGTDRYVDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMG1</accession>
    <name>A0A7K2ZMG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001434">
        <property type="protein sequence ID" value="MYW33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029829206" evidence="2">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="10775" checksum="FC11404F222F8BE7" modified="2021-04-07" version="1">MSVTRRTLLTATAAGTLLAALWFVPSANATVETASRSGAATASGTVSGQGPQTPAEDLDAEPQLAATGPGVDTTPYLIGGTVLLGLGAGFVTYSIRRSGDGDGGGARPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMS3</accession>
    <name>A0A7K2ZMS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_31415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001438">
        <property type="protein sequence ID" value="MYW33655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="402" mass="39706" checksum="492492DAA00C53A7" modified="2021-04-07" version="1">MTQVEESTGTPPTPQRSPLSGWLGVVALALGTFTVVTSEMLPVGLLTPMGESLRVSEGVAGLTLTITGLVAAVSSPVLVSMLGRTDRRMALCALVAVLVIGNLGAAWAPNFGVMVVARILVGIGMGGVWAIAAGLAVRLVPAKSVGPATSLVFSGIAVASVLGVPAGTYLGAAAGWRSAFLAAAGLGLVVLVAAAVLLPRLPAERTIPLGGVMGLFGNTQVRTGLIVVGFVVTGHFAAYTYIRPVLEDVSGVGAGMIGTLLLVYGVAGVAGNFLAGAGAARSPRKTLLVISAVMAATVIALPWLGGSVALAAVLMVVWGLSYGGVSVSTQTWILLASPDAREAASSLFVGVFNGAIALGALIGGLAADGIGITAVMWVGGALAVGALVTTTVGRSPTPAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMW5</accession>
    <name>A0A7K2ZMW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative selenoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076965864.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001443.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007423">
        <property type="entry name" value="Sel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04328">
        <property type="entry name" value="Sel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7882" checksum="BB0CD34AA9673AAE" modified="2021-04-07" version="1">MTLADVRRVAGRIRWYVRELTGESTYDRYVAHARAHDPDTPVMTRRAFEHSRTDAREADPREGFRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN92</accession>
    <name>A0A7K2ZN92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001453">
        <property type="protein sequence ID" value="MYW33758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="12482" checksum="392A202894897974" modified="2021-04-07" version="1">ALRACPASGGTVVLDEHLPDALVVSSPALGSALADRVLGPLDRLDPSDRDVILETLTAWLDADGSAQRAGARLYCHRNTVLNRLRRFEQLTGRCLTRPRDAVEVSLALAARRLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNS4</accession>
    <name>A0A7K2ZNS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001510">
        <property type="protein sequence ID" value="MYW33990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="43" mass="4678" checksum="300AE1E105BAB37C" modified="2021-04-07" version="1">TPRIAPATAYALGVLHADQRHEVEAARAVFRETWPYAAAMTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP79</accession>
    <name>A0A7K2ZP79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001550">
        <property type="protein sequence ID" value="MYW34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029442994" evidence="1">
        <location>
            <begin position="31"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="220" mass="23401" checksum="80F1664ABB53EBE6" modified="2021-04-07" version="1">MRGRQAGLPRRTLAALAAAFLLAAPATAHATAPPPPTAQGLRAFQQSYGLAPTGQVDTATAHLLKTAPDSELRGAFADPSDLGPEQLAHARTVIGVGKGADIPEQGQVIALMTAMQESKFVNYTTPVDHDSLGIFQQRPSMGWGTAKQITHVPTASKSFYGLPSPTSNPGLLQIEGWEAMEPGKACQAVQRSAHPDRYAQWEDFARDLLEREGPTVDPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPI8</accession>
    <name>A0A7K2ZPI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gabT</name>
        <name evidence="5" type="ORF">GT040_34570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001585">
        <property type="protein sequence ID" value="MYW34262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004632">
        <property type="entry name" value="4NH2But_aminotransferase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00700">
        <property type="entry name" value="GABAtrnsam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="446" mass="46502" checksum="2807EAA556F1FA86" modified="2021-04-07" version="1">MTAIPQERRVVTAIPGPKSVELQARRLAAVAAGVGSTLPVFTARAGGGIIEDVDGNRLIDFGSGIAVTSVGASAEAVVRRASAQLANFTHTCFMVTPYEGYVEVCEQLAELTPGDHAKKSALFNSGAEAVENAVKIARAYTKRTAVVVFDHGYHGRTNLTMGMTAKNMPYKQGFGPFAPEVYRVPVAYGYRWPTGAENAGTEASAQAIDAITKQIGAENVAAIIIEPVLGEGGFIEPAKGFLPAIAQFAKDNGIVFVADEIQSGFCRTGQWFACEDEGIVPDLITTAKGIAGGLPLSAVTGRAEIMDAAHAGGLGGTYGGNPVACAGALGAIETMRELDLNGKAKRIEEVMKDRLAQMQAKLPNGDIIGDIRGRGAMIAIELVKSGTKDPNPEAAGALAKACHAEGVMVLTCGTYGNVLRFLPPLVIGEDLLNEGLDVIEQAFGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPZ0</accession>
    <name>A0A7K2ZPZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001606">
        <property type="protein sequence ID" value="MYW34387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6938" checksum="4594D7BB62953F8D" modified="2021-04-07" version="1">MSVRTPTSKELGAIIAVFAFFFILVITGETMTGDGNLTQSVLFYLAVAVPGGLLVYWLATRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQD7</accession>
    <name>A0A7K2ZQD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_35855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001631">
        <property type="protein sequence ID" value="MYW34508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="346" mass="36397" checksum="466265322BC9186A" modified="2021-04-07" version="1">MTTVAAYAAPRAKAPLERTTIERRPVGEFDVLIDIKFAGICHSDIHQARDGWGEGIFPMVPGHEIAGIVTETGPGVTRFKAGDRVGVGCMVDSCGKCDACLMGREQHCVEGNTQTYNALDRGGRPTYGGYSTHIVVTEGFVVGIPEGIALDEAAPLLCAGITTYSPLRRWGAGPGKKVAVIGLGGLGHMAVKIAHTLGAEVTVLSQSLRKKGDGLKLGADHYYATSDPKTFEELAGTFDVILSTVSAPLDFGAYLALLRTDGTLVNVGAPEEPVSLNLFSLIGGNKSMAGSAIGGIAETQEMLDFCAVHGLGAEIEVIEAGQVNEAYERVLASDVRYRFVIDTATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQE9</accession>
    <name>A0A7K2ZQE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001637">
        <property type="protein sequence ID" value="MYW34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029760416" evidence="1">
        <location>
            <begin position="31"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="573" mass="60736" checksum="AAD3FDA38332FD24" modified="2021-04-07" version="1">MPRSGLYRLLMRLALVVGVWASVIGLTASAAVARPEPVPAPGDDRSGVSRYFSGPQGLAIPTAPCDPAGPSATDGTMAGQLNPQLGAKMAGYLTAYKMSCARMVTQAVKDRGLNPRAAAIAIATIIVETSMNNYSQAVDHTSIGLFQQQDWWGSREQRLNPAYATNAFLDDMERRYPGGSWNNAPVGEVCWRVQQPREDLRHLYGIEAGDATLIANALWSGTSAGPKHPYASGRVVSGQSADGRLEAFAAGADGVYHAWQTTANGAWSPWRPVGGPRNAQLAVASNADGRLELFALSDGTFDHMWQTAPSGGWSAWENFGTGGHRLAAGHNADGRIEVFASNADGVFHRWQTAPSGGWSGWEGTHGGPANARLAMENAPDGRLEVFALSDATFEHLYQTRVNGGWSAWENFGTGGRDVAAGHNQDGRLEVFASNAQGVFHRWQTGPSSWSAWTGTGGIPDAELATSRSVDGRVEVFAVNATTASHAWQTRPNAEFSPWETFGGGGTSIGTGRNADGRIEVFGTSHAGVYHRWQTGFATWSEWAWLNDAGPAMPQGVVAGSATPKGLVGGSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQQ8</accession>
    <name>A0A7K2ZQQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001644">
        <property type="protein sequence ID" value="MYW34589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16652" checksum="ACC811D1759FF1EB" modified="2021-04-07" version="1">LMSDLTGERNVVLGGLAMGMSQAEIRERYDEIVDFSGINEKGDFITLPMRTYSSGMAARLRFSIAAAKNHDVLMIDEALATGDHKFRVRSEARIRELRKEAGTVFLVSHNNKSIRDTCDRALWLEKGELLMDGPTEEVLKAYERETGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR35</accession>
    <name>A0A7K2ZR35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_37330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001688">
        <property type="protein sequence ID" value="MYW34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="110"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="366"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="507" mass="53896" checksum="78804FCE9F84DAAA" modified="2021-04-07" version="1">MSEPRPSDRHDASQPDDTFEEIVGEETQRDPDLAVIEAGSRTLRTYAGSPQGEAVPARPTDPETDQALRAVEQELAGRWGETKLEPSVTRIAALMDVLGEPQRAYPSIHITGTNGKTSTARMIEALLNAFELRTGRYTSPHVQSITERISLDGSPIEPERFIETYEDIKPYVEMVDAQQPYRLSFFEVLTGMAYAAFADAPVDVAVVEVGMGGTWDATNVIDSTVAVVTPISLDHTDRLGTTPAEIAGEKSGVIKQGATVILAQQPVDAAQVMLKKAVEVDATVAREGMEFGVTSREVAVGGQLLTLRGLGGEYEDIFLPLYGAHQAHNAAVALSAVEAFFGIGAEQARSLDIDAIRKAFAAVISPGRLEVVRSSPTVVLDAAHNPAGARAAADGISEAFSFSRLIGVVGTSGDKDVRGLLEAFEPIFAEVVVTQNSTPRAMDADELAAIAVEVFGDDRVQVEPRLDDALEAAITLAEEDDEYAGAGVLVTGSVITVGEARLLLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR86</accession>
    <name>A0A7K2ZR86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001691">
        <property type="protein sequence ID" value="MYW34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029559245" evidence="2">
        <location>
            <begin position="36"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="17588" checksum="E23161C4B7D9CD6E" modified="2021-04-07" version="1" fragment="single">MSTPVAHAGAGLRLTRAAVFTAVCVVLSAAGHAFAAGAPVPAWTLLAGFLGVLAVASALAGRERSLPSIVGALAGGQVALHVLFAYGSHGSAQTVVAAAPRGSGENPLIRFAAGLVCGGGPGQIDAADAHRIVTTAGIDPSTVAGHSHLASGAAATAAPDGGSGLAEAYASVAALLPGLPMFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR99</accession>
    <name>A0A7K2ZR99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001723">
        <property type="protein sequence ID" value="MYW34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514406.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001723.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="15823" checksum="83A86AEA59522584" modified="2021-04-07" version="1">MPPDVPVPASWRIALPHSTAAVPIARALVRTALSDIHAPADSDTAELLTAELVANAVEHTVSSEPIELVVELLPTGCQVEVHDHDPAPPGDLSRPQPGFEVDPWQEHGRGLLLIRTLSSACGHRTTEHGKAVWFTLPAIPSQPGPSPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRA9</accession>
    <name>A0A7K2ZRA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan DD-metalloendopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001722">
        <property type="protein sequence ID" value="MYW34886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="263" mass="26581" checksum="96CF9A1CA0D6C965" modified="2021-04-07" version="1">QAAPATAKKAAPKTYAVVSGDYLAKIATEHQVKGGWQKLYQDNRSTVGENPGLIFPGMKLTLGAKATGTAAPSEAKKSAPAPKAAAPKKAAPKKAAPAPKADTLSADESDAAAESGASTQTGSSESTGSGWTAPLDNANVTTQYRASGSSWSSGYHTGSDFQAASGTPVKAIGPGTVVSAGWSGSYGNEVVIKHEDGMYSQYAHQSSLSVSAGQTVTGGQQIGLSGSTGNSTGPHLHFEVRTGPSYGSDVDPVAYLRQHGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRG0</accession>
    <name>A0A7K2ZRG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001722">
        <property type="protein sequence ID" value="MYW34887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="275" mass="30618" checksum="AC8232AA395CC86D" modified="2021-04-07" version="1">MADDSRTQQQNIIGSYAAIGDSFTEGVGDPGPDGAFVGWADRFAVLLADRLPAPDAATNPDETRHGNFRYANLAVRGRLLDQIVEEQLPRAKELAPDLVTFCAGGNDIIRPGTDPDDLAERFERAVADLTGAVGTVMVTTGFDTRGVPVLRHMRGKIATYNVHLRAIADRYQCPVLDLWSLRSVQDRRAWDADRLHLSPEGHTRVALRAAQVLGHDVPADPDQPWPPQVQRRPFDERRDNIQWAREYLVPWIGRRLRGESSGDHVEAKRPDLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRH4</accession>
    <name>A0A7K2ZRH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ORF">GT040_38315</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="WWKE01001735">
        <property type="protein sequence ID" value="MYW34981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="229"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="160"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="222"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW34981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="434" mass="46623" checksum="AA45448854912F09" modified="2021-04-07" version="1">MTAQPTWLHPGHDPLAEDLSLDPVEQAIRDIAAGRPVVVVDDEDRENEGDLVIAAEMATPEIVAFMMSECRGLICAPMESDELERLELPQMVADNTESMQTAFTVSVDASAAHGVTTGISAADRATTLRMLAGGVAGPGDFVRPGHIFPLRARSGGVLVRNGHTEAAVDLAKLAGLRPAGAIVEIAGEDGTMLRLPELVPFARKHGLTIISIEDLIAYRRSAEPTVRREAATRLPTAFGDFTAYGYRSTVDGVEHVALVHGDVSENGGEDILVRIHSECLTGDIFQSARCDCGPQLHASMQRITEEGRGAVVYLRGHEGRGIGLLSKLRAYELQERGVDTLDANLELGLPADARDYAAGAQILKDLGVRSLRLMTNNPDKTAAVLHHGLAVTGREPMPVQAGEHNLRYLRTKRDRMGHDLPWLDGAPASPCANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRK5</accession>
    <name>A0A7K2ZRK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001752">
        <property type="protein sequence ID" value="MYW35030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="25959" checksum="6A3442757CA1AD81" modified="2021-04-07" version="1" fragment="single">MRWLVGWSSIAASFGTVGAVGNGGEGRTVHPVGSQLLWGDPDPLWAVGDWRPDEIRVIGVATPEGAPTARLAVLGCCGATDEQLRVGLLAARGGAMRHLTAWPGSYTAVVQIGRRITVAGDLAGARPVFHTPWANGTAYATAALPLADLIEAQLDIGHLAALLACPESPEALGDGTPYAGVKRVPPGHALILREGSREITGYEAVASLAVAAPQVDPVHAVEGVRDALVEAVRARLTAPRHAPETLPQDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRN3</accession>
    <name>A0A7K2ZRN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001745">
        <property type="protein sequence ID" value="MYW35015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="49" mass="5033" checksum="43780D062A7EEB5D" modified="2021-04-07" version="1" fragment="single">MSETPDPEVVELATKVFDLARAGDAEALAAYVDAGVPADLTNGRGDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRV9</accession>
    <name>A0A7K2ZRV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001771">
        <property type="protein sequence ID" value="MYW35086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="140" mass="14718" checksum="2C0F2F9A2E68D106" modified="2021-04-07" version="1">MYSTPPVRHADGGPSAGLPRTAGEARDVVTRLLAAEFDELSDELLSNVVVADALLVTSEIVTNALRHGGGLTGFSARITDSGLRLVVDDADPRHPVLQDPPPGSVGEGGYGWSLVHRLTRQLSVTSHEGGKRIVAVVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRZ3</accession>
    <name>A0A7K2ZRZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pheA</name>
        <name evidence="12" type="ORF">GT040_38775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001770">
        <property type="protein sequence ID" value="MYW35068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="198"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW35068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="311" mass="33208" checksum="F68B3D653A4B0CC7" modified="2021-04-07" version="1">MSATRYAYLGPEGTFTEVALRTLPEAATRELVPMVSVPAALDAVRNGEAAAALVPIENSVEGGITATLDELTSGEPLMIYREVLLSITFALLVRPGTKLSEIKTVTAHPAAQPQVRNWMAAHLPQATWESAASNADGARLVQEGRYDAAFAGEFAAATYGLEPLVTEIHDAENAQTRFVLVGRPARPSAPTGADKTSVVIWLGDDHPGALLELLQEFAVRGVNLMLIQSRPTGEGIGNYCFAVDAEGHIADRRVGEALMGLKRICPKVRFLGSYPRAGVSAEEVRPLRAGTSDSAFTEASDWLARSQDGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSM9</accession>
    <name>A0A7K2ZSM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-glycerol glycerophosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001832">
        <property type="protein sequence ID" value="MYW35307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="9712" checksum="935A89EFF94D92B4" modified="2021-04-07" version="1">YDLEHYRDTLRGLYFDFTTRAPGPLLETSEQLVKALREVDAVEAEYQDKYAQFKKDFCEPRDGRATARVVDRMLAGGPHAAASTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZST8</accession>
    <name>A0A7K2ZST8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system F family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_40600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001845">
        <property type="protein sequence ID" value="MYW35403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045980">
        <property type="entry name" value="DUF5936"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19359">
        <property type="entry name" value="DUF5936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5936" evidence="8">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="152"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW35403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="295" mass="32237" checksum="62B5AD2C12B1936C" modified="2021-04-07" version="1">MDLLLALVVGLAVYGAIHGIRMYRADAKLPGDLAVALESGSSRTGAVGSGIDRLGIRWAPMVLRMMGPKAVNKKRRQIDLAGNPGGLTIDRYAARRAVYGALGLLGAFSMLLQGQLFLALVMIAFGLFWVEAGIWSAIRVRREHIERTLPDFLDVLAVVVSAGLGFRQALDRVAEKYEGPWSDELRITLRQMDMGVSRRQAFEELRRRNDSEQVAMFVTTLQQGEELGAPIVETLIQIANDMRRTDAQNARRKAAKAVPKATFAVTSFLLPGTLVLLTVGFVYGADVDFSFLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSZ0</accession>
    <name>A0A7K2ZSZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001834">
        <property type="protein sequence ID" value="MYW35329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6689" checksum="6E164905EFDD459B" modified="2021-04-07" version="1">MYGWIWRHLPGNAWVRSVIALVLVLAVVYALFQYVFPWAEPLLPFGEVTVDGASAGGAGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z681</accession>
    <name>A0A7K2Z681_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000025">
        <property type="protein sequence ID" value="MYW27838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M4_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="13813" checksum="E9412E7157620DCD" modified="2021-04-07" version="1">GTPLRYMDKPSKDGSSADYWDENLGDLDVHHSSGVANHFFYLLAEGSGKKTVNGVEYDSPTSDGSTLTGIGREKAYQIWYKALSVYMTSTTDYAGARVATEKAATDLFGADSEELKAVSATWTGVNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6P9</accession>
    <name>A0A7K2Z6P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Twin-arginine translocation signal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000067">
        <property type="protein sequence ID" value="MYW27998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029756461" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="38" mass="3812" checksum="C3F6069F3E16F66A" modified="2021-04-07" version="1" fragment="single">MRAIRKNPMSRRSLLRALGAGAAGAALAGCGVPAAFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z755</accession>
    <name>A0A7K2Z755_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000104">
        <property type="protein sequence ID" value="MYW28143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="152"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="383" mass="42857" checksum="3D538870847F220F" modified="2021-04-07" version="1">MTRRTVRIAMNGVTGRMGYRQHLVRSILAIREQGGLDLGDGEVLWPEPVLVGRRAHALEELAARHGLTEWSTDLDAVLADDTIDIYFDAQVTSARVEAIKKAIAAGKHIYTEKPTATDVEGALDLARLARDAGIKHGVVQDKIFLPGLLKLKRLIDGGFFGEILSIRGEFGYWVFEGDWQEAQRPSWNYRTEDGGGIVVDMFPHWEYVLHELFGQVASVTAHVQTHVPRRWDEHGKPYEATADDAAYGIFQLAGGAVAQINSSWTVRVNRDELVEFQVDGTHGSAVAGLRNCRVQHRSSTPKPVWNPDLPVTESFRDQWQEIPDNQEFANGFKAQWELFLRHVALDEPYTWDLLAGARGVQLAELGLKSSAEGRRFEVPELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7A7</accession>
    <name>A0A7K2Z7A7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000124">
        <property type="protein sequence ID" value="MYW28239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22134" checksum="92DB7972C83416B4" modified="2021-04-07" version="1">PLTAPTDFTPPPARPDVAQAVDEVKKLLGEGRITQAVDILGAILPAAAAEHGEHSPVVRILRKQYAATLMDDGQYRRALPELRRLAEDPTAGTGPADLQALQFRYDAAQCLEQLGEATAALGEYRAVLPYYENAYGPVTTDPGRALDIRHRIGQLLLAVGDHTAGRAQLQALLYDAERTYGPHHPLPVDLRRRLSHQRDVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z846</accession>
    <name>A0A7K2Z846_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000197">
        <property type="protein sequence ID" value="MYW28524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="460" mass="49706" checksum="4689B539EA4BBBFD" modified="2021-04-07" version="1">MPPRTSNTADPARPPAEPRPALRVAVLADSDTRWKWGALTARRLTAAPDERGARPVEVSGLLLRGRATPTPRQLAEVGEVGIEAEKVREVTAVEFLHTVRDERYDVVVLALVGGGVQAMLHGLAALDLPRRPVIVTGYVGVVYEKLADGLLLRHGADVVLANSAHDAERFRAVYEGVGADASAVTEAALPFLGGAPYRAEEGRDTVVFAAQPSVPASRADRTYLLRRLVEHARLHPRREVLLKLRSKPGEHTTHIEELPYQKLAQKVPGGLPPNFRLVYGHMGEVLDRTDLLVTVSSTAALESLHRRIPTAVLTDLGVREPLGNHHFVGSGLLTSWDRLDGGYRPHPDGEWLAGQGVAADGSYSTAYDTARAKVAELLERSQLPPLAPYYTPATAPGYLPGILARHHLAPDGTPLPGAAAPQETGRMRGAVRETVRNAARGAYRHGVQRVAPVIRRMGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8R7</accession>
    <name>A0A7K2Z8R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exodeoxyribonuclease VII large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000249">
        <property type="protein sequence ID" value="MYW28739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="100" mass="10647" checksum="BE9C35EEB9351D83" modified="2021-04-07" version="1">VDERAAEVDALAGRSRRVLGHLLDRADSELAHTRARVVSLSPAATLERGYAVLQRPDGHVVRSPDEAGAPGEPLRARVSEGEFTVRVDGGGPRDDVAARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8S5</accession>
    <name>A0A7K2Z8S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urea ABC transporter permease subunit UrtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">urtB</name>
        <name evidence="7" type="ORF">GT040_05520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000250">
        <property type="protein sequence ID" value="MYW28741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515418.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000250.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017779">
        <property type="entry name" value="ABC_UrtB_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03409">
        <property type="entry name" value="urea_trans_UrtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="294" mass="30794" checksum="47F700C7E4D0DBB2" modified="2021-04-07" version="1">MTVILNQSFTGVSIGAVLLLIALGLTLTFGQMGVINMAHGEFIMAGAYTTYVLQKPIGDAGISLLLALPVAFLVAGSMGALLEWLLIRRLYTRPLDTLLVTWGVSLMLQQLARDIFGAPNVQTTAPGLLTGSVSVAGVNLANSRLFILGFALLCVAGLAAILRTTPLGRRIRAVVQNRDLAEVSGIATGRVDRTTFFIGSGLAGMAGVALTLIGPIGPTTGTNYIVDAFLVVVVGGIGRLRGAVITAFVLGLLQSVLEYSTTVSVAKVVVLVGIVAFLQWRPQGLYTVRTRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8X0</accession>
    <name>A0A7K2Z8X0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobB</name>
        <name evidence="7" type="ORF">GT040_05815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000255">
        <property type="protein sequence ID" value="MYW28800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="301" mass="32163" checksum="18BD7743BE840954" modified="2021-04-07" version="1">MRMRPTLSWTPTEKLSPGTTDLEPVADALSGGGVLVLSGAGISTESGIPDYRGESGSLSRHTPMTYQEFTADPQARRRYWARSHLGWRTFGRARPNAGHRAVASFERHGMLSGVITQNVDGLHQAAGSEEVVELHGSLDRVVCLSCGTLSPRRELARRLEEANERFAPVAATINPDGDADLTDEQVGDFRVVPCTVCGGILKPDVVFFGEAVPVERVEHCRALVRESTALLVLGSSLTVMSGLRFVRQAAQAGQPVLIINRDHTRGDRHAVTRVALPLGTALTTVAGRLGIPVDDGSAGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9C4</accession>
    <name>A0A7K2Z9C4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000300">
        <property type="protein sequence ID" value="MYW28954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003968990.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6213676"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="91" mass="10521" checksum="392E01C282C6AA8B" modified="2021-04-07" version="1">MLERRSSHDDLIDHLVRSTALQRGEAARVILDVLAYFDESTDDFVRRRHRELQSGGLVNTEIFERIAAELPHRAVAPPELSLRQLRRIVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9I5</accession>
    <name>A0A7K2Z9I5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="7" type="ORF">GT040_07015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000314">
        <property type="protein sequence ID" value="MYW29031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="185"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="402" mass="42335" checksum="8BBE58A4644768E9" modified="2021-04-07" version="1">MDKPKVVLGVSGGIAAYKACELLRRLTESGHDVRVVPTAASLHFVGAATWSALSGHPVSDQVWDDVHEVPHVRIGQGADLVVVAPATADMLAKAAHGLADDLLTNTLLTARCPVVFAPAMHTEMWEHPATQENVATLRRRGAVVIEPAVGRLTGVDTGKGRLPDPGEIFEVCRRVLARGVAEPDLAGRHVVISAGGTREPLDPVRYLGNRSSGKQGYALARTAVARGARVTLIEANTGLPDPAGADVVRIGTAVQLREAVLKAAADADVVVMAAAVADFRPAEYATGKIKKKDGEEAPAVSLVRNPDILAEVAAERARPGQLVVGFAAETDDVLANGRAKLRRKGCDLLVVNEVGERKTFGSEENEAVVLSADGTETPVPYGPKEALADTVWDLVSGRFPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9M4</accession>
    <name>A0A7K2Z9M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000315">
        <property type="protein sequence ID" value="MYW29034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="84" mass="8841" checksum="4A3BB138B210B69E" modified="2021-04-07" version="1">GRAQFFVAPGAATELPGLLYRMGWDDADLDLRALGPGAHITAPPSDLGGLGPVRWLRPPVLDTAAAPPQARLLLGTLAYICHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9U8</accession>
    <name>A0A7K2Z9U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03618 family F420-dependent PPOX class oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000355">
        <property type="protein sequence ID" value="MYW29130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="133" mass="14545" checksum="FE9D64798126E5DD" modified="2021-04-07" version="1">MADVRNPTPGYLAFWRERHVCTLTTLRPDGTPHVVPVGVTYDPEAGVARVITGKGTRKVANILAAGPEGARVAVCQMHKARWATLEGVATIRSEPEAVADAESRYTERYERTPRLNPERIVIEIAVDRALGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA15</accession>
    <name>A0A7K2ZA15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">gatC</name>
        <name evidence="3" type="ORF">GT040_07835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000361">
        <property type="protein sequence ID" value="MYW29190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966094.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000361.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZA15"/>
    <dbReference type="GeneID" id="63982958"/>
    <dbReference type="GeneID" id="66958374"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="10627" checksum="80FBF5E7FDCD07D5" modified="2021-04-07" version="1">MPGITREEVAHLARLARLELKGEELDHFAGQLDDIIGAVARVSEVADQDVPPTSHPLPLTNVMRADEVRPSLTPAQALSGAPAQEQQRFKVPQILGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA29</accession>
    <name>A0A7K2ZA29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arsenic transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_07855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000361">
        <property type="protein sequence ID" value="MYW29194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01118">
        <property type="entry name" value="ArsB_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="419" mass="42838" checksum="1B84B9A26AB3D1B0" modified="2021-04-07" version="1">MNTVTAELVSFALLLGVLAFAVVRPRGLPEATVAVPAAVLVVALGAVSWPEAREQVGELLPVVGFLAAILVLAQLCADEGLFRAAGDLVARACRGQTRPLLGGVFVVASLITAVLSLDATVVLLTPVVLATAARVGARPRPYVYACAHLANSASLLLPVSNLTNLLAFTASGLSFTRFAALMALPWLAAIAVEYVVFRRAFKADLAAGAHAPDPEAERTPVPVFTLVVLALTLAGFVVTSFAGFEPLWAALAGAAVLAVRALVRRETTPLAVVRSANPLFCLFVLALGVVVKAVVDNGLGGGIAAVLPDGDTLPALLGVAVVAALLANLINNLPAILALLPIVASAGPGPLLAALIGVNIGPNLTYVGSLATLLWRRILHAHGDAPELGHFTRLGLATVPATLLASTLALWGSLHLIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA96</accession>
    <name>A0A7K2ZA96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">GT040_08195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000374">
        <property type="protein sequence ID" value="MYW29258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="9"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="307"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW29258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="551" mass="60105" checksum="4B1FB36FCE46D5DA" modified="2021-04-07" version="1">MQPTSTTTKHIFVTGGVASSLGKGLTASSLGALLKARGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTNDGAETDLDIGHYERFLDVDLDGSANVTTGQVYSQVIAKERRGEYLGDTVQVIPHITNEIKHRIRRMATDDVDVVITEVGGTVGDIESLPFLETVRQVRHEVGRDNVFVVHISLLPYIGPSGELKTKPTQHSVAALRNIGIQPDAIVLRADREVPTSIKRKISLMCDVDEAAVVAAIDAKSIYDIPKVLHTEGLDAYVVRKLDLPFRDVDWTTWDDLLDRVHNPDHEVTVALVGKYIDLPDAYLSVTEAMRAGGFANKARVKVKWVTSDDCRTAAGAAEHLGDVDGILIPGGFGERGVDGKVGAIRYARENKVPLLGLCLGLQCIVIEAARSLAEIPDANSTEFDAATSHPVISTMEEQLAYVEGAGDLGGTMRLGLYPAKLAEGSLVREAYAGEPYVEERHRHRYEVNNAYRGELEKKAGLVFSGTSPDNKLVEYVEYPREVHPYLVATQAHPELRSRPTRPHPLFAGLVKAAVARRTGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAG7</accession>
    <name>A0A7K2ZAG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_08595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000402">
        <property type="protein sequence ID" value="MYW29334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="356" mass="37670" checksum="D36234870F17FE95" modified="2021-04-07" version="1">MHLSVLLAATPSPGPGGSLEEAAEQAGNAAGWVEENWSTWLSTGLRIMLIVAVAVTLRYLIRRALTNLIDRMNRSAQAVEGTALGGLLVNAERRRQRSEAIGSVLRSVASFMIMGTAALMVLGAFKINLAPLLASAGVAGVALGFGARNLVTDFLSGVFMILEDQYGVGDTIDAGVASGEVIEVGLRVTKLRGDNGEIWYVRNGEVKRIGNLSQGWSTAGVDVTVRPTEKLEHVREAITTAAETMAKEEPWSERLWGPVEVLGLDAVLLDSMTVRVTAKTMPGKSIGVERELRWRIKQALDDAGIRMIGAVPLQTEGESTADPTAAMAAPSAYASATSPQSMAATPIPPPATNLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAN6</accession>
    <name>A0A7K2ZAN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000410">
        <property type="protein sequence ID" value="MYW29404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7138" checksum="24E48BD140349120" modified="2021-04-07" version="1">MGILRKACTRCTKRGRLRRGVCRRCRVKEHGAEAADTGTDVAEVVVETGALGAVGRVFGAIVRAVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAS7</accession>
    <name>A0A7K2ZAS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000413">
        <property type="protein sequence ID" value="MYW29428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="597" mass="66036" checksum="2BE45BBDA86376F3" modified="2021-04-07" version="1">MTTTTTASSSHHLSPAFPGRAPWGTANKLRAWQQGAMERYVQEQPRDFLAVATPGAGKTTFALTLASWLLHHHVVQQITVVAPTEHLKKQWAEAAARIGIKLDPEYSAGPLSKEYHGVAVTYAGVGVRPMLHRNRCEQRKTLVILDEIHHAGDSKSWGEACQEAFDPATRRLALTGTPFRSDTNPIPFVQYEEGNDGIRRSSADYTYGYGNALADGVVRPVIFLSYSGNMRWRTKAGDEIAARLGEPMTKDAIGQAWRTALAPTGEWIPNVLSAADKRLTEVRKGIPDAGGLVIATDQDSARAYAKILKKVTGETPTVVLSDEKAASKKIDKFSADESRWMVAVRMVSEGVDVPRLAVGVYATTISTPLFFAQAVGRFVRSRRRGETASVFVPTIPMLLDFANEMEVERDHVLDKPKKGSDEENPFSEEDKLLADAERLEDEETEEQLPFEALESDAVFDRVLYDGAEFGMQAHPGSEEEQDYLGIPGLLEPDQVQLLLQKRQSRQIAHSRQKPAEEADLLEKPAEARPVVTHKQLLSLRKQLNTMVSAYTHQSGKPHGVLHNELRRVCGGPPSAEATAHQIQQRIAKVQEWATRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAY3</accession>
    <name>A0A7K2ZAY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000449">
        <property type="protein sequence ID" value="MYW29531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="21041" checksum="52158CB1DDFCEABD" modified="2021-04-07" version="1">MSDNLPPPPPEQPQPSPWAPPATPPGKPQRTGLIASLAVGGGLVVAGALVALVYSLLDSVSDSIALPPARSDAPYSDPYDEEAYGEEPYGEDPVEEERVEEKPEPVASGPAAERDVTITKCARDSLIGWQHADLTIVNGGRSPAGYVVFVEFLDAKGTVLTDGIATTDDLAPGASVKVKAQGVGEVPTGTTCRVEQVTRDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBQ9</accession>
    <name>A0A7K2ZBQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="7222" checksum="28E75787866A5C3C" modified="2021-04-07" version="1">MARPKMLKLREVLEEIDISRAAFYRMRARGQAPRLQKLPNGHVRVSRADLDAWWGTCEERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBR7</accession>
    <name>A0A7K2ZBR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000495">
        <property type="protein sequence ID" value="MYW29779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="235" mass="25777" checksum="09AEF442FEC6A704" modified="2021-04-07" version="1">MRREAEAYDLTLKYTGTDGRTSQSGTLVLGRNVDFLLNAYDTEGDGVVRTRVPRGTYLLETPVRTRKGARATPGTALMVQPELSVTKATTVTFDARRAKPVNFTVPQGAKGVDTYLKYVLESDDTTYGSVWQHDSFKGFRTGHVGAALPAKEFSSHIGGTWQKGSTTYNLHYDRARSLHTGLVHKAKAPVLNRKGKRTLSLSHPGKATSVSLKAKLTDKQGNSYQVTIVKAYLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBZ0</accession>
    <name>A0A7K2ZBZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_11385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000517">
        <property type="protein sequence ID" value="MYW29867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014298">
        <property type="entry name" value="RNA_pol_sigma-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02952">
        <property type="entry name" value="Sig70_famx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="99"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="198"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="28394" checksum="C8A34D459E3CDC36" modified="2021-04-07" version="1">MYPHVGVDASGLATLRASVIDRLRGFVPTAYAVPAFATPAPAGPCYAMAERSAAVGRRSTRAASATSTVRRPTADSDSARMMDLVERAQAGEADAFGRLYDQYSDTVYRYIYYRVGGKATAEDLTSETFLRALRRISTFTWQGRDFGAWLVTIARNLVADHFKSSRFRLEVTTGEMLDANEVARSPEDSVLESLSNAALLQAVRRLNPQQQECVTLRFLQGLSVAETARVMGKNEGAIKTLQYRAVRTLARLLPDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC53</accession>
    <name>A0A7K2ZC53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000524">
        <property type="protein sequence ID" value="MYW29888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_11" evidence="1">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="173" mass="17375" checksum="6392B4AE6EFF9FF6" modified="2021-04-07" version="1">FAEAEPLLAVMGKKAVHCGGAGAGQAAKICNNMILGVSMIAVSEAFVLAESLGLSDQALYDVASAASGQCWALTVNCPVPGPVPTSPANRDYRPGFAAPLMAKDLGLAANALRAGGIDAELGLRAAELYARFAEGAGAEQDFSGIVRTIRAASTATTDTASTATTVTEKGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCB7</accession>
    <name>A0A7K2ZCB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000546">
        <property type="protein sequence ID" value="MYW29948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029851781" evidence="1">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="17490" checksum="DCEE98C70E6FFE94" modified="2021-04-07" version="1">MRRRFTAPLAAVALSLPLTLLSAAPSSAAPADKPQVLSSWTQTSASSHNAWNAARNNQGAWAAYGFDWSTDYCSSSPDNPFGFPFQTACARHDFGYRNHKAAGTFSANKARIDSAFYEDLKRVCAAYSGAKRTSCNSTAWTYYQAVRAFGIAPTKADSTGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCJ9</accession>
    <name>A0A7K2ZCJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000553">
        <property type="protein sequence ID" value="MYW29995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="48" mass="5099" checksum="CD906A4FD92377E4" modified="2021-04-07" version="1">MTGTALAASMSEDGTTQFEPLSGLLTEAMVPVRWALEWLGPTERATCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDA1</accession>
    <name>A0A7K2ZDA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rex</name>
        <name evidence="9" type="ORF">GT040_13715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000652">
        <property type="protein sequence ID" value="MYW30316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030573738.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000652.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="89"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="26661" checksum="0174EA245CE114F4" modified="2021-04-07" version="1">MATGRTHRPATRSRGIPEATVARLPLYLRALTALSERSVPTVSSEELATAAGVNSAKLRKDFSYLGSYGTRGVGYDVEYLVYQISRELGLTQDWPVAIVGIGNLGAALANYGGFASRGFRVAALIDADPAMAGTPVAGIAVQHTDDLDRIISDNGVSIGVITTPPGAAQQVCDRLVAAGVTSILNFAPTVLSVPEGVDVRKVDLSIELQILAFHEQRKAGEDAPAEGEDPEAPPMRATPASRKGPDGDMPAVMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDB9</accession>
    <name>A0A7K2ZDB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_13900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="WWKE01000656">
        <property type="protein sequence ID" value="MYW30353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="409"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="468" mass="51079" checksum="AFDE476BF59999D2" modified="2021-04-07" version="1">MPVPQFPPGFLWGASASAFQTEGAVDADGKGPSGWDAFAAQPGRIKDGTDTTRGTGFHARYREDVALLSGLGADAFRFSISWPRVVPGGSGAVNADGLDFYDRLVDELCAHGITPAPTLYHWDTPLPLEEAGGWLDRDTAYRFAEYAGIVAERLADRVPMWITINEPAEVTMLGYALGEHAPGRTLLFDALPAAHHQLLAHGLAVRALRAAGADNIGIALSHAPVWTAGDSDEDRAGAELYDTLTNWLFADPVLTGRYPDEAIAALMPGPVADDLKVISTPLDWYGVNYYNPTLVGAPRPEALETFSGFAMPAELPFGIREIEGYEKTGFGWPVVPEGFTEILTLLHRRYGDRLPPLHITENGCALAEPLADDRRIAYLESHLTALRAAMDAGVDVRGYFTWSLTDNVEWTEGASQRFGLVHIDYETLTRTPKVSYAWYRELIRAQKQGQNHQIRKEAVEGAYAAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDH8</accession>
    <name>A0A7K2ZDH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_13985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000659">
        <property type="protein sequence ID" value="MYW30369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029598673" description="NlpC/P60 domain-containing protein" evidence="4">
        <location>
            <begin position="36"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="230"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="37018" checksum="74269D82D91DE364" modified="2021-04-07" version="1">MASHRRPKQPSRARVTVLTATAAAAVALTSQAAHADPKPTKNEVKAEVDKLYHEAEAATEKYNGAKEQQDKLKKQVDALQDKVARGQDELNDLRGELGSIATAQYRSGGIDPSVALFLASDPDSFLDQASALDQLTVKQTESLQKIQAKQRTLAQQRKEAQDKLGDLADVRKALGENKKKYQGKLADAQRLLNSLTAAERAKIQEEEAAKDRASRATSERVELGNEAPASGRGAAALSAAATQLGKPYVSGGSGPNSYDCSGLTQWAFAQAGVGISRTTYTQQNDGTKIGRSQLRPGDLVFFNGLSHVGFYAGNNQILHAPKPGTVVRYESMDYMGTFQFGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDJ2</accession>
    <name>A0A7K2ZDJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000660">
        <property type="protein sequence ID" value="MYW30378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046193">
        <property type="entry name" value="DUF6221"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19730">
        <property type="entry name" value="DUF6221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="14373" checksum="2637782FE92E1309" modified="2021-04-07" version="1">MSQDLVTFLHARLDEEADLARRCDGDDCGEWTAHGHTVDFCQVELPGFPPTIALHVALHDPARILREVEAKRRVLARHALSPATGDPELPWDNRDDCQYDGETWPCDDLLDLASPYGDHPDYPVTPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDR9</accession>
    <name>A0A7K2ZDR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lantibiotic dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000678">
        <property type="protein sequence ID" value="MYW30469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="76"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="20466" checksum="A5C727EE06958FB1" modified="2021-04-07" version="1" fragment="single">MPGGRWRLWEQFSLRGPGFPVGGVLDLAPVDVSVYADKFAGGVLSGPDWDEFEGVFGEVAARTAVRLQGVAGSSDFTAAVAWQNRTVLRTGLRPFLGWVPSASGRSSMPRQREELVAHYWQRFCVKNDTIGFFGPVGWGRVDGSVGGVEVDPGEGLTASSSVFFSSWSIDALARTLSADERLMAWIPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDS5</accession>
    <name>A0A7K2ZDS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000701">
        <property type="protein sequence ID" value="MYW30510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="10928" checksum="E1D0B3F25FFF0939" modified="2021-04-07" version="1">IRAGDTAATVVRKDPTEGASAPRASSGSLPRTTSAETLATVQAAAMTGTAVWIGYVNAEGAASQRVIAPVRVEGGFVTAYDHTADEVRTFALHRITGVAELAEDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE08</accession>
    <name>A0A7K2ZE08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_14990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000714">
        <property type="protein sequence ID" value="MYW30549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="283"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW30549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="36222" checksum="FD881C76778554B6" modified="2021-04-07" version="1">MSFPMALFVTVLLLIGSGFFVAAEFALVASKRHRMEQAVLAGQRGAKAALAGMRELSLMLAGAQLGITLCTLGLGAVSKPAISHELDPLLERLGLPAGLSYGIAFALAMALVVFLHMVVGEMAPKSWAIAHPERSAMLLSPAFRAMVKVVRPLIRVLNAVSNALVRLCRVTPRDELTSVHNRDQLTHLIEESERLGLISKGDSGLVTRSLTEPQTPVAELAIPAERIVTVPADAALDRILAVATAADRTRLLVRDGERVLGSVHARDALVARAAGREASARDLARPVPELAPEATAAHAVERLRERRATIAVVRDEQGRLSGLVSLDDLLARLLHPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE14</accession>
    <name>A0A7K2ZE14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030564213.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000719.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035183">
        <property type="entry name" value="DUF5304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17230">
        <property type="entry name" value="DUF5304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="17090" checksum="7A0E3283BC2BCF1E" modified="2021-04-07" version="1">MSEATDRPVDGDAWADACAEDLAEEKARRRAQYGPQPGSAAEELRKLVDAVADKVSSLQSPLLGVAAQGAVQQAIRQAKSAVEPVIERNPQVFDHLAAAGNELLAAYRSAVEGQESRWTRTAADPSKATPAAQADKAADDPSDPRDEGRGEGPSGTERIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE97</accession>
    <name>A0A7K2ZE97_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_15450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000723">
        <property type="protein sequence ID" value="MYW30638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510790.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000723.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="369" mass="39739" checksum="73E37FA672E49B1B" modified="2021-04-07" version="1">MSDFVPGLEGVVAFETEIAEPDKEGGSLRYRGVDIEDLVGHVSFGNVWGLLVDGAFNPGLPPAEPFPIPVHSGDIRVDVQSALAMLAPVWGLKPLLDIDEATARDDLARAAVMALSYVAQSARGQGLPMVPQSEIDKAHSVVERFMIRWRGEPDPKHVKAVDAYWTSAAEHGMNASTFTARVIASTGADVAAALSGAVGAMSGPLHGGAPSRVLGMIEEIERTGDATAYVKGALDRGERLMGFGHRVYRAEDPRARVLRRTARELAAPRFEVAEALEKAALEELHARRPDRVLATNVEFWAAIVLDFAEVPAHMFTSMFTCARTAGWSAHILEQKRTGRLVRPSATYVGPGTRNPREIEGYADIADLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEH5</accession>
    <name>A0A7K2ZEH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02775</name>
        <name evidence="3" type="ORF">GT040_16060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000117">
        <property type="protein sequence ID" value="MYW28222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01000756">
        <property type="protein sequence ID" value="MYW30751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026242069.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000756.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="24332" checksum="58937CABD7AF0918" modified="2021-04-07" version="1">MSRQTVIKAVLGPILRLMFRPQVEGAENIPGTGPVILAGNHLTFIDSMIMPICCDRPVFYIGKDEYVTGKGLKGRLMAWFFTGCGMIPVDRDGGRGGVAALMTGRRVLEEGQAFAIYPEGTRSPDGRLYRGRTGIARLTLMTGAPVVPFAMIGTDKLQPGGAGLPRPGKVTVRFGEPMEFSRYEGMDRDRYVLRAVTDSVMSEVMRLSGQEYVDMYATKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEN4</accession>
    <name>A0A7K2ZEN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">GT040_16030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="WWKE01000756">
        <property type="protein sequence ID" value="MYW30745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="397" mass="43229" checksum="2EDF5DD5C68C15CC" modified="2021-04-07" version="1">MTERVVLAYSGGLDTSVAIGWIAEETGAEVIAVAVDVGQGGEDLDVIRKRALACGAVEAEVADAKDEFAEEYCLPAIKANALYMDRYPLVSALSRPTIVKHLVAAAKKHNAGIVAHGCTGKGNDQVRFEAGISALGPDLKCIAPVRDYAMTRDKAIAFCEEKNLPIATTKKSPYSIDQNVFGRAVETGFLEDIWNAPIEDIYEYTSDPATPREADEVVISFKEGVPVAIDGSPVTVLQAIQQLNERAGAQGIGRIDMVEDRLVGIKSREVYEAPGAIALITAHQELENVTVERELARYKRQVEQRWGEMVYDGLWFSPLKRALDGFINEANQHVTGDIRMTLHAGRAVVTGRKSDESLYDFNLATYDSGDTFDQSKAQGFIELFGLSSKIAAKRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZET3</accession>
    <name>A0A7K2ZET3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000766">
        <property type="protein sequence ID" value="MYW30828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="5870" checksum="EE5CF6284110AE89" modified="2021-04-07" version="1" fragment="single">MDRILSADSTPIAYRRQGEGPPLVLVGGALSTAATDAPLAALLAPRFTVVTYDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF05</accession>
    <name>A0A7K2ZF05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000794">
        <property type="protein sequence ID" value="MYW30916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_C" evidence="1">
        <location>
            <begin position="74"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="17622" checksum="54B2B7E491CA02CA" modified="2021-04-07" version="1" fragment="single">MSAAVGLGLGGAGLLDHPVLSLGTSGVVFAASRTRSTAPALSGFAAADGTYLPLACTLNCTLAVDKVASLLGLHREDTAPGGEAVLLPYLDGERTPDLPSASGLLTGLRHDTTPQQLLGAAYEGAAVTVLRALDTLLRACGLDPDAPEVAARPLRLIGGGAQGRSWVETVRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF78</accession>
    <name>A0A7K2ZF78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000804">
        <property type="protein sequence ID" value="MYW30935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="50"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="133" mass="14400" checksum="FFE4591F7C47F55A" modified="2021-04-07" version="1">VLDPADEDARVAALDACLLALEPRPDPQAALAMELADRVRTDRSVCRAGQLARDAGLTPRSLQRLFSAYVGVGPKWVILRYRIHEALERAESDPAVDWARLAADLGYSDQAHLVRDFTATVGVPPTAYAAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF80</accession>
    <name>A0A7K2ZF80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigA</name>
        <name evidence="9" type="ORF">GT040_17475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000816">
        <property type="protein sequence ID" value="MYW31021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="282"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="361"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="450"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="515" mass="56200" checksum="EE0B0AAB3465FBDD" modified="2021-04-07" version="1">MSASTSRTLPPEIAESESVMALIERGKADGQIAGDDVRRAFEADQIPPTQWKNVLRSLNQILEEEGVTLMVSAAESPKRARKSVAAKSPVKRTATKAVAAKTTVTRTVAATAAPAAESADAVADDAVAAAPAKKAAAKKTAAKKTAVKKTAAKKTAAKKSGKQDDELLDGDEAVEEVKAGKGEEEEGEGENKGFVLSDDDEDDAPAQQVAVAGATADPVKDYLKQIGKVPLLNAEQEVELAKRIEAGLFAEDKLANADKLAPKLKRELEIIAEDGRRAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLARVQRQMLQDLGREPTPEELAKELDMTPEKVIEVQKYGREPISLHTPLGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHSVLDTLSEREAGVVSMRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFD3</accession>
    <name>A0A7K2ZFD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminobutyrate--2-oxoglutarate transaminase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_17510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000817">
        <property type="protein sequence ID" value="MYW31028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="467" mass="48926" checksum="B9CF5959DBDF9EC2" modified="2021-04-07" version="1">MSVTEPAPVAAPPAPPVHEGILRRQSLRESAARTYARSLPIVPVRARGLTIEGADGRRYLDCLSGAGTLALGHNHPVVLEAIRKVIDSGAPLHVLDLATPVKDAFTTELFATLPREFADNARIQFCGPAGTDAVEAAFKLVRAATGRDGLLTFTGAYHGMTAGALEASGGARDVRVTRLPFPQDYRCPFGIGGERGAALGSRWTEHLLDDEKGGVPAPAGMIVEPVQGEGGVNPAPDAWLRRMREITRARGIPLIADEVQTGVGRTGAFWAVEHSGIVPDVMVLSKAIGGSLPLAVIVYRSELDLWQPGAHAGTFRGNQLAMAAGAATLAYVRENGLAERAAALGARMLDSLRKLRADHPGIGDVRGRGLMIGLELVDPEAVPLPAEADDHAPAPPPDPALARAVQQECLDRGLIVELGGRHSAVVRLLPPLTLTDEQASAVVDRLADALAAAERSPHRGAAAGPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFD9</accession>
    <name>A0A7K2ZFD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhzF family phenazine biosynthesis isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000823">
        <property type="protein sequence ID" value="MYW31046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="273" mass="28829" checksum="FEB4704DEBE92903" modified="2021-04-07" version="1">MRIRIVDAFTDRPFSGNPAGVLLLESAAFPDAERLQEIATEVNLSETAFAHPLPPGGEADWALRWFTPATEVDMCGHATLATAHVLHTTGRATGTVRFTARCGILTSTAHPDGSLTLDFPTAPLREETAPPGLAEALGAEPVSVHDTGEHIGDLLVEVHDEATVRALAPDFAALKTHSRRGVIATATAEDPARGYDYVSRGFFPGVGIDEDPVTGSAHTALAPFWSARLGRDDLTGLQASARSGFVRTALRGERTLLTGSAVTVIDGELLTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFV6</accession>
    <name>A0A7K2ZFV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRC-barrel domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000865">
        <property type="protein sequence ID" value="MYW31212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030570692.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000865.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="12859" checksum="D77914C783930046" modified="2021-04-07" version="1">MIESADIREWRTRDVVDPDGRRIGSLESVYVDTGTDQPAFATVIVGLPTRHRLVFVPLAGTVVGPDYVRVAHAKAKVKDGPSIGTDDVLPAEDEPALFAYFGLEYLPPADGVRVLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFZ1</accession>
    <name>A0A7K2ZFZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1801 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000869">
        <property type="protein sequence ID" value="MYW31246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="21"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="13413" checksum="D62C3A52C4C45277" modified="2021-04-07" version="1">MVQNSAEDVDQYLAELPEARRGALTALRALCRAELTGFREVMAYGMPAYERDATGEVAFASQKQYISVCLLRTDVRDAFADRLAGHDMGEGCLRFRTPEKIDFTLLRDLLRATAATPGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG47</accession>
    <name>A0A7K2ZG47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000897">
        <property type="protein sequence ID" value="MYW31334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="19"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="449" mass="48971" checksum="27144D1ED9736848" modified="2021-04-07" version="1">MREMSADPAAADRRAGEDAQVIVVGAGPAGSSAAYHLARAGVDVILLEKARFPREKVCGDGLTPRAVHQLIRMGVDISAPGWTRSRGMHWVAGKHRVHIDWPALGRYPDFGLSRSRHDFDDILAHHAVAAGARLYSGWKAERPLTDRAGRVTGVSATPDAPDAPGPVDFRAPVVVAADGASARLALALGLERDPGRQIATAARRYYRSPERSREEYLELWADLRFPDGGPYLPGYGWIFPMGDGRVNVGLGALPHRRHGKADLRATLDQWLARTPEEWGLREENAEGPVRSAALPLGFNRHPLYARGLLLVGDSGGMVSPWNGEGIGQALEAGEVAAETAALALAHPEGARREQVLRGYPVEMNRRWGRYYRLGNAAADVVFSRSGFQPVLNRYVMNSPFLLNTLARLLTDLTDKPSRDVIDHVLNTAFRIVPAPRPGRAPGRLRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGA1</accession>
    <name>A0A7K2ZGA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000893">
        <property type="protein sequence ID" value="MYW31325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029599176" evidence="3">
        <location>
            <begin position="34"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="367" mass="38204" checksum="9FB4D052088C5FBA" modified="2021-04-07" version="1">MVRQPSEVGSRVPATLLLLLAALLALAAVPVTAAPAAPAVQAADGDAPSVTLSKKEAGKGGEITVKGGGWRSEALLMLLICGRSTPERGVIGGTNSCANADGRAVTTDKKGAFNKKLPVAEPPEPCPCVVHVATVTGEQAVIDAVFTVAGHPTAPLPPPADEGRLAVLATTRLEGESSLLTWFGAPPARQLVVTVGNLGSAPVEDPVFEIGTAHGVYAPQWEERQWRGTVAPGSKARIKLPVELSAGAHGDYQVSLRYGTKVLAEQPWGVSRPWGVTLFWVLLCLVVPAAVFRIGMAVVDKVRPRPAGLVARHAHRTRTPAAQAPPAPAALPWFTQDSAPPDIRRSAPPGNRPPPTTKGQAWTRNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGD4</accession>
    <name>A0A7K2ZGD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000906">
        <property type="protein sequence ID" value="MYW31359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1770" mass="196887" checksum="76A6F0152553839F" modified="2021-04-07" version="1">GRAALAQDAAALAEPAALAPEGWRKRYTESHLETLRALGYADAHERTVTVHSADRAYDIQVLHAEPGLYAVGCGWTTESDAALDPDGAGRLLHPVRTETSAPDLTDAKALTDFLFTCDTPPRHVLLLVGGVIVLADRLAWPEGRYLAADLDAALHRRDDRHGGELDTLAALFGSDSLRAPAEGGTAPLAAFLDRSGKHAVGVSTELREGLRLSVEWIANEVLDRLREPENGVTPADLDDPARLAKELSRESLRYLYRILFLLYAEASPALGILPSDYPEYEQGYGLQRLGDLVLRDLVGERSRRGFHLYESLDLLFEKVENGHRRYGTEPEDLAAEEAAREATKAEGEAAKLLAAGTITEAEYTDRIREADRARRAAARSTSAGLRFEALRSELFAKKAVRLISDDQIENPAYEEGGTDGRRPVLDTRLRNETLHKVLRRLMLTKGRGRERGGFISYAQLGINQLGAVYEGLMSYTGFIAEEELYEVAKGGDPSNGSWMVPASRAQDYDDAVFVKRTDEETGHRERVAHPRGAFVYRLAGRDRQTSASYYTPKSLTEVTVELALRHRLDQDGTTTPARELLEWKICEPALGSGAFLNEAIDQVAAEYLRRRERELGRKVDPELRQIELQKTKAYVALHNAYGVDLNATAVELAEVSLWLNSMHPGMRAPWFGLHLRRGNSLIGAGRKVYKADTLTGGGWLAKKNPLPPTDLPFRDGPLPEGAVHQFLLPAVGWGAVAAEPEAKKLAEDEARALGRWRKGVQKAPKGPKPFQERGEETDEARRKRYERWRKAADKTELGRLQGVARRAEFLWSLVATRLELSERAVARRVDVWGADWLDQSTEAEDKQKVLDDLTRHGTPYWRLKTVMDAWCALWFWPLDRVGELDGGDPVYGMGGALVGGAAVPGAAETAAPEQAASVAPAEPVSGPAPGDQLWRTAGLFDDPDGEQDELGEALASSDGGVRRTPAARRPSRTARPPERQVVPLQSFADWLEFLEAVLGTSDMPEESLLSGIEKLSPDDALEVLGDVEDRLEGFLGMRSAALLPFRYPWLNTVEDIAGTTEKDIRAEDGHGFFHWELHFAHVFRGAAGGFDLQVGNPPWVQPRWLENPVLAEYEPWFMLTEKPTKVERTRRRDGVLKSPRARAYLLAELASVSGMSEMLGSGPVYPLLAGTQPDLYRAFMSQTWRHMAGDGSVGLVHPDSHFSGDREGRLREAAYTRLRVHGGFVNQGNRFFAPPVGHASHFGVHIYGREKEVGFDHLSWLVSVDALRLSADDDGTAPDPGVKYGASWDERPHRKRIIRVDEQMLARWQKLTGDHTQSVRQARLLSPVSTAEAQAIEALADYSLRLAEYEPQISSGYHESGAKAADLIDYNAPDGTGVVRRPADWSEVILKGPQIGLANPMFKQPSQGAGEVLGLNPMLLADDAVPESEYVYVARPEVYRAAQDVWSDGRTLEQLKASEREGARAREAAGGRYEVEPSEITQDQMEAELLRRLRRPYTEFYRVAWRKMIAPDTERALYVALLPEGPSHIDALRSTALSDDRHTAVLGGFWASLPVDYLLRTARVGNLDVAPARRLPAPEIGHPLASSLLLRTLRLNCLTNAYADLWEELYDPTWPGYEPWACEWPELQPLHTVRPTWNRNTPLRTERARRAALVEIDALVAVWLGVSADALIAMYKARFPIMQDFDAVTWFDSNERKIAGKRHTYGFGQIKEHYEHFLAYQNKERSEPPEGYTAPFYKANREDEMREAHAYFSARLQEAIDQGKWTPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGF9</accession>
    <name>A0A7K2ZGF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_19690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000918">
        <property type="protein sequence ID" value="MYW31437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="161" mass="17215" checksum="09282A6259FB3C2B" modified="2021-04-07" version="1">MAVDALDTRILRLLIEQPRTSVREYARILGVARGTLQARLDRLERDGVITGTGPALSPAALGHPVLAFVHLEVTQGRLVEVGDALAAVPEIIEAFSTTGGGDLLTRVVARDNGHLEDVIQRLIQLPGVVRTRTDVALRERVAHRVLPLVESVGRAAAGQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGR1</accession>
    <name>A0A7K2ZGR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000948">
        <property type="protein sequence ID" value="MYW31537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="256" mass="26968" checksum="DB2CDDFF33CDEC92" modified="2021-04-07" version="1" fragment="single">GNVAVDVARILARGADELRATDVPRAALGALAGSRVREVHIAGRRGPSQARFTTKELRELGALPGARVVVDPAELAMDPAYAAQEGLPLPAVVRRNLDVLRGWSALGEPAAADAARRIRLRFFLRPVELLERGGRVAGVRFARTAPDGAGGVQDTGAYEEIEAQLVLRAVGYRGVELPGLPFDPVRGTVPHAAGRVLRDGVPSPGEYVAGWIKRGPTGVIGSNRSCAKETVASLIEDAPLLARRPAAEDPLAVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGX8</accession>
    <name>A0A7K2ZGX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="ORF">GT040_20565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01000970">
        <property type="protein sequence ID" value="MYW31604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="246"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW31604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="319" mass="32686" checksum="1B3C6682C6725286" modified="2021-04-07" version="1">MTGSRVVALGHYQPAKVLTNDDLAAMVDTSDEWITSRVGIKTRHVGGPDEPVDELAAHAGAKALAAAGLQPSDIDLVLVATSTAIDRSPSMSARVAARLGMGSPAVMDINVVCSGFTHALAVADHTIRAGAATRALVIGADKMGDIADWTDRTTCVLLGDGAGAAVVTADPSAPDTPAGPGIGPVLWGSVPEMGNAVRIEGTPPRFAQEGQSVYRWATTQLPPIARKVCEKAGITPEDLAAVVLHQANLRIIEPVARKIGAVNAVIARDVVDSGNTSAASIPMALSKLVERGEIASGAPVLLFGFGGNLSYAGQVIRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH15</accession>
    <name>A0A7K2ZH15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000970">
        <property type="protein sequence ID" value="MYW31605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="26413" checksum="5CE9996EEDDD89C0" modified="2021-04-07" version="1" fragment="single">MTARPANAHQARLLRLLRDGGPNSRAQLGDQVDLSRSKLAVEVDRLLETGLVVADGLAASRGGRRSHNIRLAPELRFLGVDIGATSIDVAVTNAELEVLGHLNQPMDVREGPVAVFEQVLAMAAKLRASGLAEGFDGAGIGVPGPVRFPEGVPVAPPIMPGWDGFPVREALSQDLGCPVMVDNDVNLMAMGEQHAGVARSVGDFLCVKIGTGIGCGIVVGGEVYRGTTGSAGDIGHIQVEPDGRACACGNKGCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH54</accession>
    <name>A0A7K2ZH54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_20955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000984">
        <property type="protein sequence ID" value="MYW31680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="27872" checksum="7E86C2215AAF8C54" modified="2021-04-07" version="1">MTTPMVKAEGVHKSFGAAHILKGIDLEVAPREVFCLIGPSGSGKSTFLRCINHLEQINAGRLSVDGELVGYRQKGDKLYELKDSEVALQRREIGMVFQRFNLFPHMTALENVMEAPIQVKGEAKAVARARAEKLLDRVGLADKAKNYPTQLSGGQQQRVAIARALAMEPKLMLFDEPTSALDPELVGDVLDVMRGLAEDGMTMIVVTHEMGFAREVGDALVFMDDGVVVESGHPRDVLTNPQQDRTKSFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHA2</accession>
    <name>A0A7K2ZHA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_21200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001004">
        <property type="protein sequence ID" value="MYW31726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="43"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="22726" checksum="2D4033C31097D38D" modified="2021-04-07" version="1">ALFAALALSEHPGRARMAGMTVALAGIGVAAVDEGAGGPVLAFVLVVAAAACWGVSNVLTRRAAPPDALAFMVWVSTVPVLPLLGLSLLFEGWDRDMAALAALDWSGVAIILFIAWVSTVFGFGAWGFLLRHHPASSVAPFTLLVPVLGMSSAALFLDESVSPLRWWAAVLLVGGVALTSLGGVRGRGARTPSAPPSVRPAASQPPAAGPTASAPPAAADAPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHK4</accession>
    <name>A0A7K2ZHK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001022">
        <property type="protein sequence ID" value="MYW31830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="PTHR33657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="31315" checksum="ED767CFEC82593C3" modified="2021-04-07" version="1">MRTPLIPAFARKVRREAPSNANASLSLRNRRAPRIATVLAAAGLLVLGTATAAHADPPQHLPQNAGGYEQTFSPAYDYDGDGCYATPAIGPDGTLAPGLKTSGAINGSCRDQWDLDNSQTYARSKCNNGWCGIVYASYFEKDQAVHGSGLGGHRHDFEHVISWVNQASNQVDYVSTTQHSTVKTYPRSQVRFDGSHPKAVYHKDGPSTHFFRLANNNDEPPENHYGNWRYPPIVDWNGFPSTALRDKLMNADFGSATIKVTDKDDRFRNLLNNSKPAGIPFDPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHM8</accession>
    <name>A0A7K2ZHM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001022">
        <property type="protein sequence ID" value="MYW31837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="139" mass="15144" checksum="8B833BF88B0660A6" modified="2021-04-07" version="1" fragment="single">MPAIPPRRLSLQQIVEGQRRAAFVGRESELSLFRRNLAIPPEDPRHRFVFHVRGNAGVGKTSLVREWQQVAGVFGALSASVDEAADSVPELLASVAGQFAEQGHQLRALDRMLVTYRRALHDVAGRLAADGDEPSPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHV4</accession>
    <name>A0A7K2ZHV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001023">
        <property type="protein sequence ID" value="MYW31839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511057.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001023.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029799297" evidence="1">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14662" checksum="63F4A9CADE87DF23" modified="2021-04-07" version="1">MTHTARRIGRSFALVLPVVMVLSGTLAVTSVPWAATDKDSTLLAASSETVSKPAKPRAAQDILRDKLLVELQEKDPGTALTGLQRAVEQRPSLARHCMSIARALGKAAVEQYGPTRAQRFSRPVCDTSFASGVAQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHX7</accession>
    <name>A0A7K2ZHX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001062">
        <property type="protein sequence ID" value="MYW31962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="31922" checksum="CAE217057DD0E42F" modified="2021-04-07" version="1">MSVVSSVLVPYTSYLRVYEPLAAFAEPERSHWARYAQRPVLPTAQDELRRSLADLVPTPPVGVPVHESGDAFVAELDGVVCVCPWRTRLRGWLALEELEGTGGQGGIFPANVLDALLPGVVRGQARADHERWQRRNPDARPWIRTTVWQVPVRWFVLFRDEEREYAAADGEGGEPVLRYRTPMVEARRRLARGLRTLRENDADGPLTEGLVDVGRWLEEFHPRSLVELDYGGLVHALPAGQLAGDRSAADVAEGLAALGNGDSEGAGEAYARLAERWRAVRDRQFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI81</accession>
    <name>A0A7K2ZI81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent RNA helicase HrpA</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrpA</name>
        <name evidence="3" type="ORF">GT040_22445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001062">
        <property type="protein sequence ID" value="MYW31959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="83"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="278"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1313" mass="148911" checksum="6A734E91811FA59E" modified="2021-04-07" version="1">MSTSFADLQSQLGQLSLRDANRLGRRLEGARRIRKPEARQSVLDEIAAEAGKAAERLATRAARLPALSYPEELPVSQKKDEILEAIRDHQVVIVAGETGSGKTTQIPKICMELGRGVRGMIGHTQPRRIAARTVAERVADELKTPLGETVGWKVRFTDQVNPESTYLKLMTDGILLAEIQTDRELLAYDTIIIDEAHERSLNIDFLLGYLARLLPKRPDLKVVITSATIDPERFARHFGEAPIVEVSGRTYPVEVRYRPLLEGADEDTADSDRDQITAICDAVDELGHEAPGDVLVFLSGEREIRDTADALNKRNLRHTEVLPLYARLSHAEQHRVFQRHTGRRIVLATNVAETSLTVPGIKYVIDPGNARISRYSHRTKVQRLPIERISQASANQRKGRCGRTSDGICIRLYSEDDFVTRPEFTDPEILRTNLASVILQMTAAGLGDIEKFPFIDPPDHRNIRDGVQLLQELGALDPAEKDPKKRLTPLGRKLSQLPVDPRLARMVIEADKNGCAREVMVIAAALSIQDPRERPQEKQTQADQNHARFKDETSDFLAYLNLWAYVREQQKERGSSSFRRMCKQEYLNFLRIREWQDIYAQLRTVAKQMGIVVEEPKGDASIPEQAVHTSLLAGLLSHIGLKDTEKNEYLGARSAKFAIFPGSALFKKQPRFVMSAELVETSRLWARVNAKVEPEWIEPLAQHLLKRTYSEPHWEKDQAAVMAYERVTLYGVPIIAQRKINFGRIDQEVSRDLFIRNALVEGDWRTHHQFFHDNRKLLGEVEELEHRARRRDILVDDETLFDFYDQRIPEHVVSGAHFDSWWKNKKREEPDALDFERSMLINEKAGAVTKDDYPDSWRQGKLKFKVTYQFEPGADADGVTVHIPLQVLNQVTSEGFDWQIPGLREEVVTELIRSLPKPIRRHYVPAPNYADKFLDRAVPLQEPLPFTLARELQRMVGVPVTADDFDLSRVPDHLKITFRIVDERRRKVAEDKDLEALKLQLRPKARQALSKAAAATAGPSGESIERSGLTDWTIGTLNKVFETRRAGQPVKAYPALVDQGDTVAVRLFDTEAEQQQAMWRGTRRLIMLNIPVNPAKFASDRLSNQQKLALSRNPHGSVQALFEDCATAAADRLIAAYGGPAWDEKAFRTLYDKVRADLVDLTVRTIDQVQQILAAWQACERRLKSTNSLTLVANVTDVREQLARLVPPGFVTATGLRRLPDLMRYLVAADRRLQQMPTAVQRDTTRMAKVHEMQDEYAWLLEQLPQGRPVGQEVLDVRWMIEELRVSYFAHALGTAFPVSDKRIVKAIDALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIL5</accession>
    <name>A0A7K2ZIL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane plasmid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_23610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043760">
        <property type="entry name" value="DUF5706"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18967">
        <property type="entry name" value="DUF5706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16110" checksum="B7A1DD90D4D61203" modified="2021-04-07" version="1">MTTAPLTISSDRNLDAACATVSGEIARTDSKASLLLAFDGAVLAGLASVADKNLPVFTKAVGGLAVLALAAAAVLLLLVVRPCLTVPGRPAPGTFPQWAHLEENELQEAMDQDHRPARVKALSILAVRKFRRLALAVDVILAALALLTVAAIGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIV9</accession>
    <name>A0A7K2ZIV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001120">
        <property type="protein sequence ID" value="MYW32255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="28"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="677" mass="73555" checksum="ED8330336B2906B7" modified="2021-04-07" version="1">MGNLPVVTTSFVGRDSELDSVDGALRDHRLVTLSGSGGVGKSRLALQTAGRVRDRYADGVWWADLSHLDDDQLLSTTVCDGVGLLDHSSRRPVAALCEWLSDRHLLLVLDCCERVVDSCRQLVTELLAAAPGLTVLATSRQPLGAEGEHALEVRPLSAGEDGDEAVRLFHDRAATVVPGLVLDSPGDTAAVAEICRRLEGIPLAVELACAQLRESSAQEITGRLACRLDALSDDTLWPRRHRALRTTIGWSHELCAPLERLLWARLSVFRGVIMTADAEAVCAGGPLGAEAIGPALESLAEQSVLRRTGDGYRMLDTLREYGAMWLAELGEDALLADRHARHFAQTAVQAHAGWLGPQQVEWYRRVASTHADLCAALEHLLAEDPERAMEMAGCAGLFWSCCGHLHQARAYLERVLALPLSAGPHRTRALWALGITLTLQGDHEAARRVGTECEEAARLGQDAEGALSAAHSMSFTYLMMGRPQTAHLVSDHALRLHPGDPADTPSQMRCRVIRLFALSALGRLDEAYEEATRLQRISLRFGEHWARAYADHQLALIHLLQGRPRHAESHARAMLASKHELHDSLGIALGLDLLAGAIAAQGDGVAAARTSGTGHTYWRIIGHPHRGTPELGAIREQWELQARQAAGNTAYERAYRRASADDAERGLAHALERQLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ13</accession>
    <name>A0A7K2ZJ13_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmB</name>
        <name evidence="5" type="ORF">GT040_24485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001150">
        <property type="protein sequence ID" value="MYW32340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003965989.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001150.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6707" checksum="946207D8CAC8EF59" modified="2021-04-07" version="1">MAANCDVCGKGPSFGNSISHSHRRTSRRWNPNIQRVRAVVGRTPKRLNVCTSCIKAGKVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ44</accession>
    <name>A0A7K2ZJ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001154">
        <property type="protein sequence ID" value="MYW32373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="100" mass="10573" checksum="008A35DF09FA6A60" modified="2021-04-07" version="1">MRIQVSRTGGFAGISRHHEVDTEGQEDAAEWESLAEEVLAAAPSSTEDGTPSGTPDAPPSGVPDGFRYRITVGDRTVYCADPDLTGAQRTLVSRVLKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ47</accession>
    <name>A0A7K2ZJ47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001154">
        <property type="protein sequence ID" value="MYW32380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13212" checksum="85FE8993B34AA02E" modified="2021-04-07" version="1">GAYAVDGRTGAAAQVPAIEVEALDPTGAGDVFVAGFVTGTLADWPLADRLAFAGLTAALSVQEFGGSLSAPGWAEIAAWWQRIRTLDDQDPTALERYAFLEELLPTTARPWPLRRAVPTIGFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ58</accession>
    <name>A0A7K2ZJ58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ybeY</name>
        <name evidence="8" type="ORF">GT040_24690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001154">
        <property type="protein sequence ID" value="MYW32378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511552.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001154.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="18145" checksum="1810F3523C4A49BC" modified="2021-04-07" version="1">MSIDVNNESGTEVDEQAILDIARYALARMRIHPLSELSVIVVDTDAMEQLHIQWMDLPGPTDVMSFPMDELRPPAKDEEEPPQGLLGDIVLCPEVAKKQGEEAPTQHSMDEELQLLTVHGVLHLLGYDHEVPEEKAEMFGLQAAIVDGWRGERGLTGASPAPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJH0</accession>
    <name>A0A7K2ZJH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="1">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GlcN6P deaminase</fullName>
            <shortName evidence="1">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">nagB</name>
        <name evidence="3" type="ORF">GT040_25290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="2">
        <location>
            <begin position="10"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="27200" checksum="3B12817C5DB3DCDF" modified="2021-04-07" version="1">MEVVIVPDATAGGELIAEAIASLLSRKPDALLGVATGSTPLPIYRALAAKVAAGAVDASHARICQLDEYVGLPVGHPESYRAVVLREVVEPLGLSKASFMGPDGSAEDVQAACEAYDRALAEAGGVDLQLLGIGTDGHIGFNEPCSSLASRTRIKTLTEQTRVDNARFFDDDIDQVPHHVITQGIGTILDARHPILLATGEGKAEAVAQTVEGPVASIVPASALQLHPHATVVVDEAAASKLKLADYFRATYAAKPAWQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJP9</accession>
    <name>A0A7K2ZJP9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_25740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001200">
        <property type="protein sequence ID" value="MYW32580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029734730" description="Peptidyl-prolyl cis-trans isomerase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="78"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="225"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="33028" checksum="C3CB761FADAB2B7E" modified="2021-04-07" version="1">MRRIAGLLVAPLLLLSAVACGSDDKASDSASSKNGVPAITAGAKFGEKPTLSKGKGDPPKELKTEVISEGDGAKLKNGDAIQVNYLGQSWDSDKPFDNSFDRKQPFDLTLGAGMVIQGWDKGLVGQKVGSRVQLVIPPELGYGEQGQGDIKPNATLVFVVDILKATQIPATAKGTEVAQDNIDLPKVGVKTDGKAPTVTIPKGDPPKKLVSNYVLESDGEVIKESDSVVVNYVGMIWKGAKEFDNTYSTGKTQTFPLSQVTLKGLKTGLIDKKVGSRVLLVIPPDQAFGDQQQQAIPKNSTLVFAVDILAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJY1</accession>
    <name>A0A7K2ZJY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SigE family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_26110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001213">
        <property type="protein sequence ID" value="MYW32653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="29609" checksum="ACF64D583D38C457" modified="2021-04-07" version="1">MNALHSTSSSAVVTRLHDVGRSAEKSGATNVTNMRGCVRSAGRQHLPSPAAAEQARKPYMTVVDAPTGERTGENGGSAYGEVTGDRTRTETEAAEAAFTAYVQERRASLYATAYHLTGDRFEAEDLLQSALFSTYRAWDRISDKAAVGGYLRRTMTNLHISAWRRRKLNEYPTEELPETVGDTDAMRGTELRAVLWQALARLPELQRTMLVLRYYEGRTDPEIASILDISVGTVKSSIWRSLRRLREDEVLSFGRDEQESFGELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKD1</accession>
    <name>A0A7K2ZKD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001234">
        <property type="protein sequence ID" value="MYW32709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="26308" checksum="5F505042E601CC28" modified="2021-04-07" version="1" fragment="single">MSAEAARPRAVLTVLPARETVTVALSPAPPASEAANGRRVLRLARVPGGPTGITEITDPSPSGGWVDPSPPFGQEVRYAALPLRDGRIDGPPVVSDVLLVAPDVWGLRSTTGRGRIEATWTEPSGALGVRVQLVGPGGPVDGADVRTGALTATGLGVGSYVLRVHCRYRSPDGAVIESAGAEHPASVDPWPTPVDRLDATAARGSVRFSWSGGDDADVRLVAWPTGPPEPGAELTDDPARPWPAPLPWETGEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKM4</accession>
    <name>A0A7K2ZKM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001273">
        <property type="protein sequence ID" value="MYW32891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="22158" checksum="B8E5FB83C230D567" modified="2021-04-07" version="1">MWINGPFGGGKTQTAYEIRRRLPGSVVCDPEHIGFGLHRTLPPHLRGDFQDLAAWRAGVREVLGLALAGHPHPVIVPMTLVDPGYFAEIVTALREDGHTVHHSALLADRATVLRRLRERGLGRGLKRESFAVRRLDDCLERLARPEFARHVRTDDVTVSQVADLVAGAAGLTLTPDTDGRLRHRLRRTWTGLRHIRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKQ4</accession>
    <name>A0A7K2ZKQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001258">
        <property type="protein sequence ID" value="MYW32829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029913160" evidence="1">
        <location>
            <begin position="24"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="61"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="37204" checksum="B377241E3B6EDD25" modified="2021-04-07" version="1">MQNRIRPAALVLAAALALTGCGADVTQQSDGKNDSAKADRHYPVTVENCGQKKSYDKAPQRVVTNDVGITEIMFALGLEDHMAGYVMPDDKGDMTSVPWKDGYKKTTWLSKERINKELVLGARADLVFAGWNYGFNEGEGFTPAELKRVGVDSYLLSESCRNGQGKARGVMPPLEALYTDLGNLGKIFDVEDRADTLIASFRKQVADAQAKAPKGSDRPRVFLYDDGKDKPLTSGAYAGPHDIITKAGGDHIMKDLKDSWTTVGWETVVDRDPEVIVINNYGDTSAEQKRRFLKTYKPLANVSAIKNDRIVVLDYVDLVESPRNPAAISSLAADLRKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL64</accession>
    <name>A0A7K2ZL64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline shock response membrane anchor protein AmaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001316">
        <property type="protein sequence ID" value="MYW33097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="99" mass="10769" checksum="6CF5B23CA53ECF44" modified="2021-04-07" version="1" fragment="single">MRSTVNRVLLALAGLVLIVVGGAVLAVGLGASLPSWWPWDGKNDVLLSASDRGRWRDEGWWWPAVIAVLAVLVVLALWWLLAQLRRGRLSDVLVDSGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL93</accession>
    <name>A0A7K2ZL93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lonely Cys domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001321">
        <property type="protein sequence ID" value="MYW33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="611" mass="65492" checksum="F3E4D9665362D5DE" modified="2021-04-07" version="1" fragment="single">ALRSGPLDVDAVARRIWHLAPSVLVDPEMRRDLYTLTGRALAAGRATGLAALTAFHLEEQGLLADDRARHVTAGGNRVPGLNWTGTATTGLDTLFVDRLTTGPTGAPAPTGQADIAPWPWDPAPYPVLADGSHDRVTAQLPDGTTWELDADEFAELVAADLTRHPLPEHAPIVLAVPSAGDRYLELPRKLAERTGRTVWVHSGLAQRNPDPAATNTVAVLHRDGLPDGTWLPVRPGLAPDPDDGAPAWHSEVLTQPIVSSRTGEQTGRSFHQPAELVGERESYRDLDHMSFYVHWDAATNTYSGKLPMRDPGPADKAYRLAGHGLPGGLSLPLADGSSRTVDRDEAAGWLRRRRSLTSLPQDHWVDLVICHSGAPGQGSAQDVSQLDGVLPAPFTTDPLGDDALSLGQHLANQLRRTTRLSYSSQGVVRFGDGPVRVLATDAQGRPWWWETSHPEPDDAELDRLAEQAGFQGDPSPRVRSELLRVVRALKLVVGPDVQVADDFPVLVAGAAAVVNMWFADPELQPTGPFWPQLLTQVIAAHPLAAGGVDGDVTRQVLAEAAKAWRNAGGALPVNRFVPLPQLRTAAAWLSDPAAVDRAAVDALRLTDPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL96</accession>
    <name>A0A7K2ZL96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001327">
        <property type="protein sequence ID" value="MYW33122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="100" mass="10435" checksum="CEE6C4093F5863DE" modified="2021-04-07" version="1">RASAPRAGRVLLVGDAAGYTDALTGEGIALAVATATAAVGCLAAGRPEEYPARWTRTTRRYRLLTQALLGAAGHPVSRRMIVAAAHRAPALFRTAVRALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLK8</accession>
    <name>A0A7K2ZLK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_29190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001355">
        <property type="protein sequence ID" value="MYW33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="42"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="436" mass="44292" checksum="AABEAEB7C688A922" modified="2021-04-07" version="1">MPPADTGASTVVVDASAPSSPVITSRATAPTSVERLEPGRPGYRKMSFALFAAGVAAFALLYSTQALLPAISASYGVSAGQASWTVSAATGALALCVLPLSALSERFGRRQMMTASLTVAVLVGMMVPFAPSIGWLIALRAVQGAALAGLPASAMAYLAEEVRPKALIAAIGLFVAGNSIGGMSGRILTGWVAQAWGWRAALASVGLLAVACAVAFHFLIPKARNFTPGTLNPKALAKTVATHLGNPLLVRLYAIGALFMTVFGAVYTVIGFRLVEEPFSLPQGIVGSIFLVYLVGTVSSAAAGRLVARLGRRGALYLAVSTTAAGLLLSLSESLAAVLLGLVLITAGFFAGHAVASSSVSRTATTGRAQASALYQSAYYLGSSAGGTLGAVAFHAGGWAATVALGLLAVIGVVSITLYGTRVARAERRPLVPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLL1</accession>
    <name>A0A7K2ZLL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001358">
        <property type="protein sequence ID" value="MYW33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="18492" checksum="C4550C89C3CEEB03" modified="2021-04-07" version="1">MAASPLTVAVLEIDAYASTLGWDQPARLFALVDTARLRVQEPGLAAQLGLDDAASTTASLTPIEQEELPAGAALDDFLGTIAWPDSVAGCAMTVERLMLPPSAEASVPDGLSDKQLTQWVAKHPDRQEVRMTVAVLRDGARESAVRLREKDSPTEVLTGAGLVPGLAEALAATFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLN0</accession>
    <name>A0A7K2ZLN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001358">
        <property type="protein sequence ID" value="MYW33246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="201" mass="21568" checksum="AF0471570717F5BD" modified="2021-04-07" version="1">WTPQNKQLMRVDLTMGGAGVLARQGSMVMYQGKVDFGYKGAGFVGRAVGNATGQEMQLMRCTGRGQVFLAEEGSYLHPIELQGDAICVSAESVLAFDESLQYEVRRVEGHGIPGGALFTMQFQGTGTVIIKTHGTPVVLPVTPTTFADCNAVVAWSAASQVIVSSQVRLRRNAYPGHSGETVNLQFRGAPGNFIVVQPYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM10</accession>
    <name>A0A7K2ZM10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rplJ</name>
        <name evidence="10" type="ORF">GT040_29815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510603.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001382.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW33348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="19426" checksum="F57CF17CDB0E3F1A" modified="2021-04-07" version="1">MARPDKAAAVAELADQFRSSNAAVLTEYRGLTVAQLKTLRRSLGENAQYAVVKNTLTKIAANEAGIDTLDDLFSGPTAVAFVTGDPVESAKGLRDFAKDNPNLIIKGGVLDGKALSADEIKKLADLESREVLLSKLAGAFKGKQTQAAQVFQALPSKFVRTAEALRAKKEEQGGAGTPAPAEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMC8</accession>
    <name>A0A7K2ZMC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001416">
        <property type="protein sequence ID" value="MYW33524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6510" checksum="FD061C7EC922CE64" modified="2021-04-07" version="1">MPRLALYALVVCVLAVVAAVVSFVQGSLLGIIWVLIAGLSSNMVWFYVRKQRMEAAAEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMF7</accession>
    <name>A0A7K2ZMF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Primosomal protein DnaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001420">
        <property type="protein sequence ID" value="MYW33531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="50" mass="5181" checksum="620174C3BE276A61" modified="2021-04-07" version="1">PGESWERMLIRVVPGRGAALAGALKTAQAARTAKGGGDQVRIRIDPPDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMI1</accession>
    <name>A0A7K2ZMI1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA</name>
        <name evidence="6" type="ORF">GT040_30995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001435">
        <property type="protein sequence ID" value="MYW33573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018489839.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001435.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="11908" checksum="69190902182D269C" modified="2021-04-07" version="1">MAGDLKHVTDDTFDDVVLKSEKPVLVDFWAAWCGPCRQIAPSLEAIAAEHGDQIEIVKLNIDENPATAAKYGVMSIPTLNVYQGGEVAKTIVGAKPKAAILRDLEGFISAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMZ1</accession>
    <name>A0A7K2ZMZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001448">
        <property type="protein sequence ID" value="MYW33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="41" mass="4352" checksum="4FE80F961F7ECEE5" modified="2021-04-07" version="1" fragment="single">METARVLVAADKFKGSLTAVQVAERVTAGLRRVVPGVRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN68</accession>
    <name>A0A7K2ZN68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001463">
        <property type="protein sequence ID" value="MYW33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="14140" checksum="A573BD16CC59A5B7" modified="2021-04-07" version="1">GAPLRLLLAAPYLLFALDPGVPVAVVAVVLASVGFSASLLLQERLMALTPQELSGHALGLSSSGMLAMQGVGAAVAGSVAQLTSPGTGMATVAVLSLAVTVALAPGLRAGRGQEAAGRLQGDGSPDGSPDAPPRTKETKETTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNJ3</accession>
    <name>A0A7K2ZNJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_32705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001493">
        <property type="protein sequence ID" value="MYW33902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="26246" checksum="C9B045FBAF910F94" modified="2021-04-07" version="1">MSIWEILAVFAAGVGAGTINTIVGSGTLITFPVLLATGLPPVTATVSNALGLIPGSISGAIGYRKELAGQRRRILKLSVGAAIGGLTGATLLLALPSTAFETIVPVLVALALVLVILQPRISKAVQRRRERTGTPARPDGGPLLFTGLTLASVYGGYFTAAQGIIYLSLMGMLVDDTLQRLNAVKNVLAAVVNTIAALFFLFVADFDWTAVVLIAVGSAIGGQIGAKVGRRLSPALLRALIVVVGSAAIVQLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP98</accession>
    <name>A0A7K2ZP98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001544">
        <property type="protein sequence ID" value="MYW34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046037">
        <property type="entry name" value="DUF5995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19458">
        <property type="entry name" value="DUF5995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="209" mass="23061" checksum="73463533436A0F60" modified="2021-04-07" version="1">MAQIEQFAEPAVLARPHRWPPGDGVGVFHDVRQAMGWRAAPAGTLEARLAERYLSALAAADAGRQAPECRRPLFRYRCHTGVRPVQFALAGLHAHIAHDLVLAVVDTCRARDCEPAALEGEFERVGDLLALLEERIHDELMPGPDLLRIADPLTHLVSTWSLERAREAAWTAARVLRQLRGFPAAAEEFAERNDAGAGLVVRFLLTPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPA1</accession>
    <name>A0A7K2ZPA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fbaA</name>
        <name evidence="14" type="ORF">GT040_34190</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="WWKE01001557">
        <property type="protein sequence ID" value="MYW34191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW34191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="343" mass="36621" checksum="9D14EDA1BD41BCC5" modified="2021-04-07" version="1">MPIATPEAYAEMLDRAKAGKFAYPAINVTSTQTLHAALRGFAEAESDGIVQISTGGAEFLGGQYNKDMVTGAVALAEFAHIVAAKYDVTIALHTDHCPKDKLDGYVRPLLAVSAERVAKGLNPLFQSHMWDGSAETLADNLSIGQELLAQAAAAKIILEVEITPTGGEEDGVTHEINDELYTTVDDALRTAEALGLGEKGRYLLAASFGNVHGVYKPGNVVLRPELLKDLQSGVSEKYGKPAGSQPFDFVFHGGSGSTAEEIATALENGVVKMNLDTDTQYAFTRPVVDHMFRNYDGVLKVDGEVGNKKTYDPRTWGKAAEAGMAVRVTEACANLRSTGTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPB2</accession>
    <name>A0A7K2ZPB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur carrier protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiS</name>
        <name evidence="1" type="ORF">GT040_34135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001554">
        <property type="protein sequence ID" value="MYW34182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032771849.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001554.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="6606" checksum="B8CBFC1EAD910DB8" modified="2021-04-07" version="1">MSVSVNGEPRVLDAGTALDRLVATLTTAPSGVAAAVNECVVPRGQWAATTLGEGDRVEVLTAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPG7</accession>
    <name>A0A7K2ZPG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ORF">GT040_34580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001586">
        <property type="protein sequence ID" value="MYW34264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="326" mass="35151" checksum="429205429D26F66A" modified="2021-04-07" version="1">MTATPARRVLLAAPRGYCAGVDRAVIAVEKALEQYGAPIYVRHEIVHNKYVVQTLEKKGAIFVDVTAEVPEGSIVMFSAHGVAPTVHAEAAERKLATIDATCPLVTKVHKEAVRYAKEDYDILLIGHEGHEEVIGTSGEAPDHIQLVDGPEDVANIEVRDESKVVWLSQTTLSVDETMETVGALKSKFPNLLSPPSDDICYATQNRQIAVKKLSEDAELVIVVGSKNSSNSIRMVEVALDAGADAAYLVDFASEIDEAWLEGVSTVGLTSGASVPDVLVDGVLEWLAERGYEDVETVKTADESITFSLPKELRRDLRAEAAALSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPP1</accession>
    <name>A0A7K2ZPP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_34820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001591">
        <property type="protein sequence ID" value="MYW34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="507" mass="54304" checksum="79995045A6E891B3" modified="2021-04-07" version="1">MPHEVDQSFLALPLRALADAALARARALGATHADFRLERVRSASWRLRDARPAGASDSTDLGYAVRVVHGGAWGFASGVDLTMDAAAKVASRAVAMAKLSAKVIAAAGSDERVELADEPVHGERTWVSAYDVDPFSVPDEEKAALLAEWSGRLLGADGVAHVDASLMTVHENKFYADTAGTVTTQQRVRIQPQFTAVAVDSATGEFDSMRTIAPPAGRGWEYLTGTGWDWDAELEQIPGLLAEKMRAPSVEAGTYDLVVDPSNLWLTIHESIGHATELDRALGYEAAYAGTSFATFDQLGKLTYGSPVMNVTGDRTAEHGLATIGYDDEGVEAQSWDLVKDGTLVGYQLDRRIAKLTGLGRSNGCAYADSPGHVPVQRMANVSLQPDPGGLSTEDLIGGVERGIYVVGDRSWSIDMQRYNFQFTGQRFFRIENGKLAGQLRDVAYQATTTDFWGSMEKVGGPQTYVLGGAFNCGKAQPGQVAAVSHGCPSALFRGVNILNTTQEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPP6</accession>
    <name>A0A7K2ZPP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001595">
        <property type="protein sequence ID" value="MYW34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15269" checksum="A6CC1D45B13F89E1" modified="2021-04-07" version="1">MTTAVDRFRAAVDTRDLSALDDLFTEDIRLYSPVKFTPFEGRPMVLGLFGVLLRTFEDFRYVGEFAGTAETSADGSEAPAAVLLFRATVNGKEIHGIDLVHLAEDGRIKEFTVMVRPRSAVHALGEAVLAGLVADGLAPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQF1</accession>
    <name>A0A7K2ZQF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001646">
        <property type="protein sequence ID" value="MYW34596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="54" mass="5243" checksum="6E054D4CD4D6320F" modified="2021-04-07" version="1" fragment="single">MTVLVVSGTGTEIGKTVVTAAVAAAARGRRVAVLKPAQTGLAPGEPGDAAEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQG5</accession>
    <name>A0A7K2ZQG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001641">
        <property type="protein sequence ID" value="MYW34565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029630412" evidence="2">
        <location>
            <begin position="30"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="237" mass="24987" checksum="739B129468641DD4" modified="2021-04-07" version="1">MHYTKKIIGLAAVGILAVGCGSGDSSGTAATPAADSKPDTVKETTAAPQAAALPVAVDGPQKDVLDSSSDGQLKVLPKPENSAPFAERVEHKLQEQVLGRVKVPGKTSAECPDGVTQKAGAVSTCNVTYEGAVIPYEVKISDSYKEGSFMTFYNAKPLKGLIVAKVVYNQLFEQYGSRSDASKLACEEFPAATAVDFDADSGLTCQYWSKYGNQGDGGYETLRVKAGNYGPSFEQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQJ6</accession>
    <name>A0A7K2ZQJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ORF">GT040_36300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001646">
        <property type="protein sequence ID" value="MYW34595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="309"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="425" mass="45726" checksum="6E4569AEC8DAA600" modified="2021-04-07" version="1">MRALDRAHVWHPYGPMPGRQEPLIVESASGVRLRLAEPVEGQRELVDGMSSWWSAVHGYNHPVLNEAARGQLDRMSHVMFGGLTHEPAVRLATRLVEITPEPLQHVFLADSGSVSVEVAVKMCLQYWRSAGRPEKRRLLTWRGGYHGDTWQPMSVCDPDGGMHELWSGALPRQVFADAPPDGFDAEPDPAYVARLRELITAHADEVAAVIVEPVVQGAGGMRFHSPAYLRVLREACDELDVLLVFDEIATGFGRTGKLFAAGHAGVSPDVMCVGKALTGGYLTMAATLCTSRVAEGISRGEVPVLAHGPTFMGNPLAASIASASVDLLLGQDWEGEVARIGAGLRSGLAPASDLPGVVDVRVLGAIGVVQLDHEVDMAAATRAAVREGVWLRPFRDLVYTMPPYVTGDDDVQRICRAVCAAAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQN3</accession>
    <name>A0A7K2ZQN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001677">
        <property type="protein sequence ID" value="MYW34676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031423">
        <property type="entry name" value="Phosphatase_SCO2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15698">
        <property type="entry name" value="Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="275" mass="29760" checksum="CB36E7685CC68B58" modified="2021-04-07" version="1">MPIPSRAALVDHLVRSRIAGDVATPRDNNLSHYRKLANGDRHYWLGLELGDRWTDEQDVLAVMAERCGVNDDPAHRMGQDTIDPELTVDALERMAARLRKAADGHERVLFATGHPGGLLDVHRQTADALRRAGCEIVRIPSGLIADEGLVVQFADVAMLERGATLWHTHSPAPMAAILDAMAHQGRPLPDLVVADHGWAGCAGQRGLDAIGYADCNDPALFLGEAEGTLQVTVPLDDHVTDPRFYDPMTDYLLHAAGLLEDEAEAEGEAAQEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQP7</accession>
    <name>A0A7K2ZQP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001661">
        <property type="protein sequence ID" value="MYW34637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="11988" checksum="B207FC6776E97BAC" modified="2021-04-07" version="1" fragment="single">MNGKATTTRTKLERGRSALGPALELVHTGRAPTRAVLTSELGVTRATAGAVAAELEALGLIRVDSSPGSAAGSQGRPSHRLSVLEDGPVVLAAQVHADGFRAALVGLGGRIVATSPGCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRG2</accession>
    <name>A0A7K2ZRG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formimidoylglutamate deiminase</fullName>
            <ecNumber evidence="2">3.5.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.13" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001726">
        <property type="protein sequence ID" value="MYW34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050416">
        <property type="term" value="F:formimidoylglutamate deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02022">
        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="45"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="336" mass="35694" checksum="40F2D1FF74692082" modified="2021-04-07" version="1" fragment="single">MDHAWLGTHVEPDVTVEVADGRIAGVRTGVETPPPGATVLRGLTLPGLANAHSHAFHRALRATVQVGSGTFWTWRELMYQVASRLTPDTYFDLARATYAEMALAGITSVGEFHYLHHAPGGTPYANPNAMGEALIAAAAEAGIRITLLDTAYLAAGFGEKPNRHQLRFSDTTADAWAERASLLKGDDLTLIGAAIHSVRAVPAGQLATVAAWAEERNAPLHVHLSEQTAENDACLAAHGRTPTRLLADHGVLGPRTTGIHNTHLTEEDVALLGSSTTGTCMCPTTERDLADGIGPAVALQKAGSPLSLGSDSHAVIDLFEEARAMELNERLRTHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRS9</accession>
    <name>A0A7K2ZRS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001765">
        <property type="protein sequence ID" value="MYW35056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="1">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="20578" checksum="B32B8A88A24DBE89" modified="2021-04-07" version="1">RLGHHVTVVDPSPNALFALERRAAEAGVADRVRGVQGDILGLFDVVERGGFDAVLCHGVLEYVDDPAEGVRNAVAALRPSGALSLLAAGLGGAVLARALAGHFTEARQALTDPAGRWGEGDPVPRRFTAEQLAELVSGAGLEVGAVHGVRVFADLVPGVLVDTEPGAMDALLKLEAAVAELPAFHSVATQLHVLGEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSA0</accession>
    <name>A0A7K2ZSA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001773">
        <property type="protein sequence ID" value="MYW35099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="532" mass="57448" checksum="36A3A3EFDE9F3FC2" modified="2021-04-07" version="1">MDQEPGHSFNRRVRLLVEVPNQPDETALVEELLTAQGWSVREATVEERTSIAFPRTGRVVEVRLRGARRGARRAAVRRVESLASRAKVPLWVRQSVLLEYPRERRTLYRARLRPPDQGTFAARRLLRLVRQIDGSHDQRALSLAGAPDRARALNELGASRLGGRPFDPEREELTGPPDLPGDAVPPDPWLDPETPGGLWSLALTVVGVLLSMLVCLAVGGLIQALDTPWRWLGLGPVAGAASAAGALVGAAPPLRPRPLVLLGSAAGCAVLVFCGYQLLAVTEGTGGSIALRAVVMPLFVLLALAVGYGVHWALVPSWFSRHASWLVPALLAPLLLLLPWFGRLLYTVYLTIGFGIPVESVPLTTYSMMYAALKPMAVAAGFALFFVGVAGWARHLYWGRIPGESSPTFLLPLSALQYIVTALLLGVLSAGYAWGDAVGAVREGRTPPGYYGLRGTLMCVELKDPDIPVYNAPLVTDRPVVTFGASGERVWLWAPSQRGSGSDQGRAMSVRLEDVTLTRPAVAKDRDCRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSD1</accession>
    <name>A0A7K2ZSD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tryptophan-rich sensory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_39095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001776">
        <property type="protein sequence ID" value="MYW35129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="13297" checksum="49D842617DC529E8" modified="2021-04-07" version="1">YAALDRPAWAPPGWLFGPVWTVLYGMIAVAGWLVTRRPGPVRRPALVAWGVQLALNALWTPLFFAAEQYGPAFLDIALLLAAVAATALLCARVDRRAGRLLAPYLLWVGYAAALNLALWLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSU5</accession>
    <name>A0A7K2ZSU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001859">
        <property type="protein sequence ID" value="MYW35451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16836" checksum="2B64C5E48AE5E026" modified="2021-04-07" version="1">MQKITPCLWYDGQAKEAAEHYIAIFGGDSRILDISYYGEEAPGETGSVLTVSFRLAGQEYTGLNGGPQFPFTEAISLSVDCADQAEVDRLWTALSEGGEEGQCGWLKDRYGVSWQIVPNELPKLLADPDPAKAERTMKAMLSMGKLDVQALRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5X5</accession>
    <name>A0A7K2Z5X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="230"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="641" mass="69231" checksum="2FD152B511DEEB28" modified="2021-04-07" version="1">MPGLLRDYFVVLPDSVAGHAVAGRLPVPDTTRTAGGAGGTVTVAHPSGRPWVVARPLVRKVSHLRRGDDALVLIGPDRVPEAVLAGLLEGARDRAGLERRLARLPGLHHVIAHLSGETWIRGTASGLRRIYHARYAEAGTIASDRPAVLAHLTGAPLDDGALALRMLDFLPHPLSRRVLWRGVHETGAGYGLALPAAAPGTAAAPGPREYRWWEPPPPELSLAEGARRLGDAVAASVRAHVGGLDRISCELSGGLDSTTLTFAARATAPAELSLLTVAARDRYSEDETWARRAVEAAHGGHTDTPAPAHHIIPADQAPYFYADLAATSAELNDEPLPVAPGRARAHLLLSRARATGSRYHLTGYGGDELFLGLPHAYQDLFHGNPLTAWNHLSGLRHQLGWPLLPTLKALLNRSTFPHWLAGAVTTEPQPVTRTPLLSWGVRQSLRPWFTDHANALITEEFRAAAAGQAEPIDRWRGRHVDIDAVRMGARHFQAMEDIGMTIGLPVAAPFYDDRVLEATLAVRLEQRISPWRYKPLLVEAMRGVVPDALLARTTKDHMSSDEHQGLREHAPDLADLWTGSRLAGHGLVDARQLLRLAAEPFSPVLVEHSISSTVAGETWLRTAENAWSAPHSTLPTSEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6T7</accession>
    <name>A0A7K2Z6T7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000076">
        <property type="protein sequence ID" value="MYW28032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029633213" evidence="1">
        <location>
            <begin position="38"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="68"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="330" mass="34964" checksum="46383F6F7CFDCF5A" modified="2021-04-07" version="1">MTAKSLQHRSRLLAAASLTVAAALALSACGFSTESGSASGSDSDGSGEAPRTVKTAMGEVKVPAAPQRVVVLDTAELDSVLTLGVKPVGATHADVDSGFLDYLPKDQVAGITDVGQMMTPNLEAIAGLKPDLILTSKIRHGDKYAELSKIAPTVMTENTGYPWKENFQVHAEALSKQAEAKMVTDDYARHVADVTKALGGKEKAGATEVNMVRFVEGADIRIYGKKNYIATILADVGLGRPAITDKAADGFSYDVSPEKIDLADADAVFHSTYGDPKKSKETRTTGSGLWKNMDAVKNGKVFAVDDQLWIQGIGYTAADKILSELRTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z703</accession>
    <name>A0A7K2Z703_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GT040_02280</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000102">
        <property type="protein sequence ID" value="MYW28127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW28127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="275" mass="30501" checksum="1EA5F69172384D62" modified="2021-04-07" version="1">MPEGHTIHRLAQDHAERFVGGPVRVSSPQGKFSDSAALLDGHTLTTTDAHGKHLFLGFGETGWVHIHLGLFGKLGFGTAPPPPPTDTVRLRLVNAAHHADLRGPTTCALITEPEKRAIHERLGPDPLRGDEDGERAWQRISRSRTTVAALLMDQKVIAGVGNVYRAEVLFRHGIDPYRAGKDLTRAEWDAIWADLVELMHEGVRNNRIDTVRPEHLPETMGRPPRKDDHGGEVYVYRRANLPCHICESEIRTADLAARNLFWCPRCQDPGASSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7F6</accession>
    <name>A0A7K2Z7F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000144">
        <property type="protein sequence ID" value="MYW28286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="34178" checksum="131AFD09CE7B4665" modified="2021-04-07" version="1">MGAVGLGCMPMSWGYSTSQQHGDRSVRTVHAALDAGVRLLDTADMYGPFTNELLVGRALKGRRSEAFLSTKCGLLVGDQHIVANGRPGYVRRACDASLRRLQTDVIDLYQLHRADPEVPVEETWGAMAELVTAGKVRSLGLCAVGARAPRRSGAGPHAGTIRQLERIQQVFPVSAVEAELSVWSPEALEELLPWCAARGVGVLAAMPLGNGYLTGTLKPGQGFEPEDLRARHPRFTAEMMAANQPVVAGLRRIAERRGASVAQVALAWVLRQGPHVVAVPGAKQEKWAVENARAAEMELDEADLAEIAGLPRARGSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7M8</accession>
    <name>A0A7K2Z7M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000146">
        <property type="protein sequence ID" value="MYW28359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="19126" checksum="6C10EF2380D868FB" modified="2021-04-07" version="1">LFKKGAKSVLDGKVKYGKEYDTKEWKPENANANMEAAITALGKDKIDGVYSANDGMAGGIITALKAAGLSPLPPVTGQDAELAGVQRIVTGEQFMSVYKSYPAEGIVAAEMAVALAKGEKLDSIATSKVDSATTKGIPTVLVPVISLTKDNIKDTVIKDGIWTLDEICSGKYKASCDKIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7U1</accession>
    <name>A0A7K2Z7U1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_03845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000160">
        <property type="protein sequence ID" value="MYW28427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="158" mass="17028" checksum="2CBCDC46B94A100F" modified="2021-04-07" version="1" fragment="single">MEQLTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIINECGPMPTQAVRWLAAGIAEALQSIHGAGLVHRDLKPSNVLVVEDGPRVIDFGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7V4</accession>
    <name>A0A7K2Z7V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000155">
        <property type="protein sequence ID" value="MYW28402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="215"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="34211" checksum="C0CA13396155034E" modified="2021-04-07" version="1">MPAPTPHRVAVLVLEGAKPLDVGIPAQVFTTRASMPYEVRVCGAESGLVTGGDGLSYSVAHGLRALEWADIVFVPGYRSPDREDPPQAVVDALIGAHDRGARLAAISTGAFALAATGLLDGKRATTHWHYTRALAARHPLVRVDENVLFVDEGSVLTSAGAASGIDLCLHILRGDLGVAASNHAARRLVAAPYRSGGQAQYVPRSVPEPLGERFAATREWALHRLGEPLTLDTLAGQAGVSPRTFSRRFVEETGYTPMQWVMRARIDVARELLERSERSIEQIAADIGLGTGANLRLHFQRVLGTTPSEYRRTFTRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8C1</accession>
    <name>A0A7K2Z8C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000210">
        <property type="protein sequence ID" value="MYW28599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029894104" evidence="1">
        <location>
            <begin position="35"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="514" mass="54015" checksum="38D967A9BBBE4898" modified="2021-04-07" version="1">MSRGMSRRSVLATTAAAASAAAVGSLATATTAHAAPPALPDGTSKDKVLVVGIDGLRHDVIAAASAPHLKGMMANGTYGTSLLYANPMAATSSGPGWSTISTGVWPDKHGVKDNSFAGKNYTRYPGFLARLAQVRPQLSTYAAVDWKPLDAQGTVTAGADAKLVLDGDRDGYTGHDATIAADTESILRNQNPDVVFAYLGQVDIVGHNLGAASAQYRQAIDVIDGYLGRLLAAIKARPAYATERWTVIVATDHGHTDAGGHGGSTIEERRTFVLAQGPGIAAGATPRDTRLVDVAATVFKQLGIAPDPAWGLDGKPIQERSTDPFEALYPALAGRVDETGIPAGVLGWTHTAPSGWSVINSAMGTGGVAEWRGWSFATDEFWSRSQRDQSRELNVRSRGIFAVADSDEWDDKASSGPFDSTLVTPAYAVGGNSTVTLDFTTLYRQEGSQSARVLASWNGGTPTLVRSYTSDVISQPQSLGLSVPAGATSVSFRFHYTGANNWYWVIDGVKITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8F1</accession>
    <name>A0A7K2Z8F1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000209">
        <property type="protein sequence ID" value="MYW28598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="6"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="480"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="918" mass="98422" checksum="DE58816BB19D7D71" modified="2021-04-07" version="1" fragment="single">MAPVDGGYPLSFAQEQLWLLDQLRSGDAAEYLMHETFRIRGPLDTEALNAALTETAARHEVLRTRYADEDGVGIQIIDEPEPVKPELVDLGDVPDERREQGLREFGASWASRPLDIRREHPWRVAVVRLAPEDWALLLTFHHIAFDGWSWGLLADELRESYAAFASGGAPAPEDLELQYADYAEWQREWWTAQPELMDRQLGYWRDRLTDTTPLGLPTDRPRPAQWDATGDTVAFTVPAPLAAGFSALAKEQGTTLFMAGLAAYQLLLGRYSGAEDIAVGVSLANRDDARLERLIGLFLNTVVLRTDLGGAPDFRELLSRVKSTTLDAYSHQEVPFERVVADLAPERDPGRNPVFQAGFALHNAHRRPFALLGLEVARVAGGSRSSAFDLSLHLTERPDGTIGGEFIYPTALFDGVRMERMAENFLHLLGQVVASPGTPVDRLELTAPAERAVLTAWGQGASRPASEDRSGHGLVAMVLDRAAATPDATAVAYDGGSVDYAGLVGRITGLAVRLREEGVRPGTPVAVSLHRGPELVTAILAVLAVGGVHVPLAPDLPEGRREFLLSDSGAALVLTEEALRDGFGEGTPVRALDAEWAGTGPDALPAAFPHQAGPEEAACVVYTSGSTGTPKGVVVTHGGLRNRVLWSVEAYAMTAADRLLQKTTIGFDASLWEFLSPLVSGGTVVMAPADAHRDPSVMAAAMDRHRVTLLQLVPSVLRLLVQEPALSRCTALRLVSSAGEPLPARLCERLRAAVPGVEVSNTYGPTECSIDSTAHRYTGEGLPGAGTVAIGAPLTGVGVSVVDRADLLVPVGVPGELCVRGAGLARGYLGRPGQTAERFGADPYATVPGGRWYRTGDLVRWRDDGTLEFLGRSDDQVKIHGVRVEPAEIEALLLAHPAVTASAVVARPGAHDQLELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8P3</accession>
    <name>A0A7K2Z8P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000247">
        <property type="protein sequence ID" value="MYW28714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="667" mass="71673" checksum="D98C0530C5224463" modified="2021-04-07" version="1">MHTLNLGILAHVDAGKTSLTERLLHTAGAIDTLGSVDDGSTRTDSLALERRRGITIKSAVVSFTLGATTVNLIDTPGHPDFIAEVERVLGVLDGAVLVVSAVEGVQAQTRVLLRTLRRLRIPTLLFVNKTDRPGARYDSLLTSITERLSPDTVAMGSTRHLGTRSASTTPFTGSDPGFTGALTDLLTRHDDELLTAYVDDPAALTHARLLEALAEQTARCRVHPVFFGSAATGAGIDALADGITGLLPAATGDAEAPARGTVFKVDRTANGERTAYVRMAEGTVHAREVLRFRSPDGREGEDKVSAVTVFEDGGEVPVSAVGAGRIGRLKGLTGIRIGDSVGEARAEAGRRHFAPPTLETVVVPVRPEDRGTLHVALGRLAEQDPLIAVRRDDLRQEVSLSLYGEVQKEVIQATLADEFGVDVTFRETTTICLERPAGTGAAVEIIDTDPNPFLATVGLRVDPAPYGSGVEFRREAELGSMPYSLMRAVEETVLSTLTQGIHGWQVTDCAVTQTHSGYWPRQSHSHGTFDKSMSSTAGDFRNLTPLVLMDALRRAGTQVYEPMHRFRLELPTDTFGALVPVLARLRAVPGPPGMRGALCTLEGELPAARVHELQQLLPGLTRGEGMLESAFDGHRPVTGPVPDRPRTDHDPLHRKEYLLRTVRRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z980</accession>
    <name>A0A7K2Z980_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_06440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000298">
        <property type="protein sequence ID" value="MYW28920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="33687" checksum="BDFC8F4DDDCA2F0F" modified="2021-04-07" version="1">MPSPQKDKGAVKVDLGGREVTVPKGGLYDRYRMDPDLDAIARDQRVSGVDFFRRLPKTKVDSPIGPTLTPNFYYAMSTARLTMLAPSKAIRTRLPEELSPLELVPGLGIVSVMFFRYDVCDIDFYTEATVGIAVKPARHGKLGFLDLVTGLKNERLDAYVLSLPVSSDIAQVRGHDGYGFPKWVTDLDVDIDDSRTTARVANDAGGVDLAFSAATPTQRAYVSGERVGSLTSYTSINGGWHSTLNQTHVLNAGTTRSTRDVSLQLGEGRMSDDLRSLKPKRTIQFDVMTEGQAALHMPVPTSVPPRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9E3</accession>
    <name>A0A7K2Z9E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000285">
        <property type="protein sequence ID" value="MYW28885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="127" mass="12270" checksum="D7FFB0C20C6E1A55" modified="2021-04-07" version="1" fragment="single">VRAATTAKADVIAVTVALPRKDTELTKAVAEARKAGAVVVAAATPEPPSRGSADEIPTRTYWPAGEPGVLAVADMLPSGARPDGALSTGDVDLAAPGAGVVSGGPRGKGHYLGGGVAVATAYAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9E6</accession>
    <name>A0A7K2Z9E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000302">
        <property type="protein sequence ID" value="MYW28963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="278"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="37253" checksum="9D5024036B682C6E" modified="2021-04-07" version="1">MHFVAQAPQQGAQWAAELHEFAVAFYERAIGRGEFDPLRIAEELGAPPRYAEHAVGVLRELRLVKQAESRADRLVAVSPEAAQMELLVPLEREILDSRHRLAGFKGQLSAFAAAFERQSRTRAEPVVIAGDQDEIELRLLEAAQSCTTEVLVMQPCVARETRELRLARPLVLEALRRGAHGRILYPHTARGDSGTRAHLGELLPAGGQVRTTKEVSDRFLVFDRKTAFIPSGEDGEIAVVYESTVAAFLAGLHARIWESAVDFDSGAAGYAGTMGELKATLLSLLASGAKDEVIARRVGMSERTLRRHVATIMQDLSASSRFQAGVLAARTGLVDLALRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9G0</accession>
    <name>A0A7K2Z9G0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="7">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">metG</name>
        <name evidence="11" type="ORF">GT040_06765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000304">
        <property type="protein sequence ID" value="MYW28983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="14"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="10">
        <location>
            <begin position="388"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="313"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="537" mass="59371" checksum="27B75D78E3F31E48" modified="2021-04-07" version="1">MAATGSEKQGATAYYVSTPIYYVNDAPHLGHAYTTVAGDVLTRWHRQRGEKVWYLTGTDEHGQKIMRTAEANNVTPQAWCDKLVEEAWKPLWEHLNIANDDFIRTTEKRHTDRVQEFVQDLYDKGEIYKGGYEGPYCVGCEEYKLPGDLLDGEGEFAGQKLCPIHKKPVELLKEENYFFKLSEYGPKLLEFYAANPGFIQPESARNEIVNFVEQGLQDLSISRSTFDWGVPVPWDDKHVIYVWIDALLNYATAVGYGANQEKFDGTFPADVHLIGKDILRFHTVIWPAMLMAQGLPLPGKVVANGWLMVGGEKMSKSNLTGIKPQDLTSHFGVDAYRWYFLRAIAYGSDGSFSWEDFTARYTSELANDYGNLASRVAAMVGKYFGGALPEATAAGDAERAVQEGLAKAVATADQKIGEELDFQSGILAIFDFVKQVNGYITEQEPWKVAKDTTPEGQARLATILYTAAEALRGVAVLLNAVMPETSQSLWESLGAEESLGALADQKVQDAGAWGTLPAGATVTKGAVLFPRLEEKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9J5</accession>
    <name>A0A7K2Z9J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000300">
        <property type="protein sequence ID" value="MYW28945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="23561" checksum="784995ED9606D257" modified="2021-04-07" version="1">MSHRHWPLHGLRIRTPRLELRLPDEALLDELASVGAGGVHAPDRMPFIVPWTDGEPDEVGRAGYQHVLGTIAGWTRQDWHLSLAVLHGGEVVGRQDVMGREFGVRREVMTGSWLGLPHQRQGIGTEMRAAALHLAFEGLGARYAVSDARADNAGSLGVSRRLGYEPDGLQIEVIRGEAVTLRRLRLDRTGWEKHRSVDVTMEGLDACRADFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9J7</accession>
    <name>A0A7K2Z9J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaL</name>
        <name evidence="2" type="ORF">GT040_07065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000316">
        <property type="protein sequence ID" value="MYW29041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="172" mass="17450" checksum="D304A99E5AB9689A" modified="2021-04-07" version="1" fragment="single">MLDADFFHRWMAATATAVERKADRLTELDSAIGDADHGSNLQRGFTAVAAVLEKDAPATPGAVLTLAGRQLISTVGGASGPLYGTLLRRTGKELGEDAEVTRDQLAQAFAAGVAAVGQLGGAQAGDKTMLDALLPAAEALASSFQGAADAARAGAEATVPLQARKGRASYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9W4</accession>
    <name>A0A7K2Z9W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Potassium transporter TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_07685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000357">
        <property type="protein sequence ID" value="MYW29161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="427"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="680" mass="72095" checksum="D4306C3B0C475A9F" modified="2021-04-07" version="1">MLGFVPPLPQQPGHPPAGRPQSGRPQPGRPPATGHMIVCGDDALARRLAVELRFVYGERVTLLLPPGRDANSPETPLTQRGRAAALFGRMSAAMNRTAANGNGSTGGNDTNAGVEAVRIMEAPEPSDDVLEEAGVDRAAALALVYDDDERNIRAALTARRLNPRLRLVIRLYNRKLGQHLEELLDQAAAVAMPGIDPALLDASTTVLSDADTAAPALAATALTGSSKVIQAEGLLLRAAERPPPRPGETLDPGLCTLALLSSTTNDPAGSEGSEGSGAEGPQLLPDEQTVAASEGRGTVVLEAISQAGPDRPATRMGGRGAPLAKIFSRRLRWSALGFVLAAVALVVVSVLTTEDSLLHSAYLILLDLLSMNDPSEDGTTARKIIQIFSGVAGILLLPLLIAAVLEAFGTLRTASSLRRPPRGLSGHVVLLGLGKIGTRVLVRLRELDIPVVVVEEDPDARGIPLARSMHVPTVLGDVTQEGVLEAAKIRRAHALLALTSIDTTNLEATLYARSVKPDLRVALRLYDDEFATAVYRTLRTAHPQALTRSRSVSHLAAPSFAVAMMGRQILGAVPVERKVMLFAALEVAGHPQLEGRTVEQAFQASSWRVLAIDATPPADRNPDLAAVPPYPPQGTPTPSGLVWDLHPGYMLRAQDRVVIAATRRGLAELLRRQRTVAPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA88</accession>
    <name>A0A7K2ZA88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000385">
        <property type="protein sequence ID" value="MYW29291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="269" mass="30033" checksum="AF6BA9D15B5F0595" modified="2021-04-07" version="1">MNAPNDHQGKLATSRAHSARVYDYILGGKDHYPVDEEAGDAMCRHWPALPVHMMENRRFMHRAARFLAEERGIRQFLDIGTGLPTSPNLHEIVQEVAPESHVVYVDNDPIVLAHARALLQSSPEGATAYVDANMHDPGTILDSPEFRELIDLNRPVGLMVIGIMHFILPPDDRRLVQDLLNPLPSGSYLAMTIGTADFAPEEVNRVAQEYREQGMPFVLRDLQTATSFFDGLELQDPEVTQVHAWRPGPEQNGIDGRDIAMYGAVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAF1</accession>
    <name>A0A7K2ZAF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000391">
        <property type="protein sequence ID" value="MYW29313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="11884" checksum="0FDCEE331AC6E757" modified="2021-04-07" version="1" fragment="single">MSEENAIRLLLADDHPVVRAGLRAVLDTEPDFRVVGEAATAEEAVARAAAGGFDVVLMDLQFGPGPGMHGSEATAAITAVPEGPRVLVLTTYDSDADILAAVEAGASGYLLKDAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBR1</accession>
    <name>A0A7K2ZBR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_10890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000494">
        <property type="protein sequence ID" value="MYW29773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513669.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000494.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="149"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="27384" checksum="698F8C855DA8FC0B" modified="2021-04-07" version="1">MTTTTAPQGRTELLRPDRTPVRVLVVDDEAPLAELLSMALRYEGWEVRSAADGAGAVRAARDFRPDAVVLDVMLPDMDGLAVLGRLRRDLSDVPVLFLTARDAVEDRIAGLTAGGDDYVTKPFSLEEVVARLRGLIRRSGTALAAERSQSTLTVGDLVLDEDSHEVSRGGDAIHLTATEFELLRFLMRNPRRVLSKAQILDRVWNYDFGGQANVVELYISYLRKKIDAGRTPMIHTRRGAGYLIKPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC26</accession>
    <name>A0A7K2ZC26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000504">
        <property type="protein sequence ID" value="MYW29825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18425" checksum="3817ECD388DC6926" modified="2021-04-07" version="1">MAARSRYAELARQLSAVGAVKRGLARALPPECPGGSAAVLTLLDRHGEMRISRLAELMAVDLSVTSRHVAHVAEHGWIERSPDPADKRSRILRLTPGGRAQLDELTRRTTEMFARNLADWSDEDVGRLNALLSRLRDSFACRGPGGCAPGSHSGECRNGLGDDAYTRTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC81</accession>
    <name>A0A7K2ZC81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000546">
        <property type="protein sequence ID" value="MYW29949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="352" mass="35809" checksum="49A7DAA05F2043C0" modified="2021-04-07" version="1">MTFVDEVKNAVTPRAALLVIGVLGLQLLFIASYVGALHKPKPTDVAFGVVAPQQMSQQLVSQLDGLPGGPLDPRTVSSEAEAREQIMNRDIDGALIVSPQGRTDTLLVASGGGTVLSSALERILTQVEAGQQRTVRTVDVAPASPDDFDGLSSFYLVVGWCVGGYLCASILAISAGTKPANRQRALIRTAVMAVYAVAGGIGGAVIIGPILGALPGSVWGLAGLGALVVFSVGMITLALEALTGIVGIGLAVLIIVIAGNPSAGGAFPLPMLPDFWRAIGPALPPGAGTWVARSIAYFRGNAVTGPLLVLSAWAVAGTALTLLLSMRRRSGRDDGRTEAASSPSPSGGSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCA0</accession>
    <name>A0A7K2ZCA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_11985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000551">
        <property type="protein sequence ID" value="MYW29984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036761">
        <property type="entry name" value="GDH_Mll4104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1670" mass="184216" checksum="9CE881A8A7F478F6" modified="2021-04-07" version="1">MQTKLDEAKAEQLARAAQVADHSPGGGVGGPGGIPRVRVAASGADEDARAGQDAVLAYLQRYYLHTAPEDLGGRDPVDVYGAAASHYRLAENRPQGTANVRVHTPTVEENGWTCSHSVVEVVTDDMPFLVDSVTNELSRQGRGIHVVIHPQVTVRRDVTGKLIEVLSGGPGTPKTSKGRKDKGGKDTPAELPHDALVESWIHVEIDRETDRADLQQITADLLRVLSDVRETVEDWGKMREAALRIADDLPGEPLDDLAEEEVEEARELLRWLAADHFTFLGYREYELKDSDALAAVPGTGLGILRSDPQHSVDEDHPVSPSFDRLPADARAKAREHKLLVLTKANSRATVHRPSYLDYVGVKKFDAKGNVVGERRFLGLFSSAAYTESVRRVPVIRRKVAEVVEGAGFSYNSHDGRDLLQILETYPRDELFQTPVDQLRAVVTSVLYLQERRRLRLYLRQDEYGRYYSAIVYLPRDRYTTGVRLRLIDILKEELGGTSVDFTAWNTESILSRLHFVIRVPPGTELAHLTDADADRIEARLVAAARSWADGFGEALNAELGEERAAELQRQYGHSFPEGFKADHSPRAAVADLVHLETLKEGEKDFALSLYEPVGAGPGERRFKIYRTGEQVSLSAVLPALQQLGVEVVDERPYELRCADRTHAWIYDFGLRMPQTNGHTGHLADDARARFQEAFAAVWKGEAENDGFNALVLGAGLNWRQAVVLRAYAKYLRQAGSTFSQDYMESTLRNNVHTTRLLVSLFEARMSPGRQSAGTELTDGLLEELDGALDQVASLDEDRILRSFLTVIKATLRTNFFQNADDGTPHSYVSMKFDPQAIPDLPAPRPAFEIWVYSPRVEGVHLRFGKVARGGLRWSDRREDFRTEVLGLVKAQMVKNTVIVPVGAKGGFVAKQLPDPSVDRDAWFAEGIAAYRTFISALLDITDNMVAGEVVPPADVVRHDEDDTYLVVAADKGTASFSDIANEVAVAYGFWLGDAFASGGSAGYDHKGMGITARGAWESVKRHFRELGHDTQTEDFTVVGVGDMSGDVFGNGMLLSEHIRLVAAFDHRHIFLDPTPDAATSYAERRRLFELPRSSWADYDTGLLSAGGGIHPRSAKSIPLNNHIREALGIDASMSKMTPADLMQTILKAPVDLLWNGGIGTYIKAVPESNADVGDKANDAIRVNGEELRAKVVGEGGNLGATQLGRIEFARDGGRINTDAIDNSAGVDTSDHEVNIKILLNGLVRDGDMTVKQRNKLLADMTDEVGALVLRNNYAQNVALSNASAQAPSLLHAQQRFMRRLEKDGALDRALEFLPADRQIRELLSNETGLSQPELAVLIAYTKITTADELISTVLPDDPHLQKLVHAYFPSQLRERFPEAVDGHALRREIITTVLVNDTVNTAGSTFLHRLREETGASIEEIVRAQFTAREIFGLSAVWDAVEALDNQVAADVQTRIRLHSRRLVERGSRWLLGNRPQPVAIAETIEGFRDGVEQVWNELPKLLKGADLDWYHSILDELTSAGVPSELAVRVAGFSSAFPALDIVAIADRTGKGPLEVAEVYYDLADRLRITQLMDRIIDLPRADRWQSMARASIREDLYAAHAALTSDVLSVGDDSATPEERFGAWEEKNAAILARSRSTLEEIQGSDAFDLANLSVAMRTMRTLLRTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCI9</accession>
    <name>A0A7K2ZCI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000558">
        <property type="protein sequence ID" value="MYW30018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="465" mass="51167" checksum="C0BEE2182F0C2B09" modified="2021-04-07" version="1">MTDGGPQGFDLKRLLAERGHERYDLHARHLNHQLPRMLHTIGFDKVYERAEGAYFWDAEGNDYLDMLAGFGVMGIGRHHPVVRQTLHDVLDAQLADLTRFDCQPLPGLLAEKLLGHSPHLDRVFFGNSGTEAVETALKFARYATGKPRVLYCDHAFHGLTTGSLSVNGEGGFRDGFAPLLPDTPIALGDLDALRRELKRGDVAALVVEPIQGKGVHAAPPGFLREAQELLHRHKALLIADEVQTGLGRTGDFYAYQHEDGVEPDLVCVAKALSGGYVPVGATLGKEWIFRKVYSSMDRVLVHSASFGSNAQAMAAGLAVLTVMEDEETVAGARRTGDLLRERLSALVDRYELLHEVRGRGLMIGIEFGRPTSLKLRSRWTMLQAARKGLFAQMVVVPLLQKHRILTQVSGDHLEVIKLIPPLIIGEAEVDRFVAAFTEVMDDAHSGGGLMWDFGRTLVKQAVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCL3</accession>
    <name>A0A7K2ZCL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000577">
        <property type="protein sequence ID" value="MYW30062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="22585" checksum="9249E453E7CC8283" modified="2021-04-07" version="1" fragment="single">PAMAGSYVGRLGQLRDLDALVSPDPVRRSHVMAVVGAPGVGKTALAKHWAHARREHFADGQLFVDLRGHSPLPALRPVDVLAQFLRALGATPRRLPADEDEAAALYRTLLADRQMLIVLDNARDAEQVRPLIPGAQGCAVVITSRSRLAGLVASDGARQLALDVLDPDEARRLLGSIVGECVASAEEEAARRLVRLCGGLPLAIRIAGANLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCT1</accession>
    <name>A0A7K2ZCT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="8898" checksum="0596040EE9D0FAAB" modified="2021-04-07" version="1">MHRLDNGQPIRDAIREAGLSIERLADRTKEVDPAGYGISQSAIGHMVSTGASGRASFTRRSCDLAAKALDKPVEELFTNTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD83</accession>
    <name>A0A7K2ZD83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000652">
        <property type="protein sequence ID" value="MYW30306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="24541" checksum="00D607F872803F67" modified="2021-04-07" version="1" fragment="single">MERRSGTTREGNAVVATPEAEQFAALLKELKDRSGRSYGVLAGRLHVSTSTLHRYCNGDAVPNEYAPVERFARLCGAAGDELVEVHRRWIVADAARRRPAGAGGAAETAAPVPATSVPVAAAESVAAPESVVAPETVPVAEPASGRFPWARLSRRTRVLLAAVGVAALLVPATVVAADLVGARAEDGAGAPGPGARADDDTFTPPVATDLQPSRTSASPSASASPSASPSSGAPSAVPSAEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDK1</accession>
    <name>A0A7K2ZDK1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">GT040_14370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01000668">
        <property type="protein sequence ID" value="MYW30434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="304" mass="33600" checksum="6E1AE2C1CE44594E" modified="2021-04-07" version="1">MSGFVEKPEPVQVPGLTHLHTGKVRDLYRNEAGDLVMVASDRISAYDWVLPTEIPDKGRVLTKLSLWWFDQLADLVPNHVLSTELPPGAPADWEGRTLICKSLRMVQVECVARGYLTGSGLTEYNASRTVCGIGLPEGLVDGSELPGPIFTPATKAAVGDHDENVSYEEIAREVGVESAAELRRTTLDVYRRARDIAHQRGIILADTKFEFGFETTDDGTERLIIADEVLTPDSSRFWPAATWKPGSAQPSYDKQFVRDWLTSPASGWDRASEQPPPALPQEIVDATRAKYIEAYEVLTGSNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDL7</accession>
    <name>A0A7K2ZDL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF255 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000658">
        <property type="protein sequence ID" value="MYW30365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="673" mass="71934" checksum="2177D7A9BD77117E" modified="2021-04-07" version="1">MANRLTQTTSPYLLQHADNPVDWWPWSPDAFEEARRRDVPVLLSVGYASCHWCHVMAHESFEDESVAAYLNERFVAVKVDREERPDVDAVYMEAVQAATGHGGWPMTVFLTPDAEPFYFGTYFPPEPRHGSPSFQQVLEGVSAAWTDRREEVAEVAGRIVADLAGRSLAHGGDGVPGEAEIAQALLGLTREYDEQHGGFGGAPKFPPAMVVEFLLRHYARTGSEGALQMAADTCSAMARGGIYDQLGGGFARYSVDREWVVPHFEKMLYDNALLCRVYAHLWRTTGSAEARRIALETADFMVRELRTAEGGFASALDADSEDQRGKHVEGAFYVWTPAQLREVLGEEDGAFAAAYFGVTEEGTFEEGASVLQLSGEGRPVDAGRVADVRARLLAAREERPRPGRDDKVVAAWNGLAIAALAETGAYFERPDLVERATEAADLLVRVHLGEVARLTRTSKDGRAGANAGVLEDYGDVAEGFLGLAAVTGEGAWLEFAGFLLDVVLEQFTGEGGQLYDTAHEAEKLIRRPQDPTDSATPAGWTAAAGALLSYAAYTGSEAHRTAAEGALGVVKALAPRAPRFIGWGLAVAEALLDGPREVAVAGPVGGELHRTALLGRAPGAVVAAGEGPGAGAEFPLLVDRPLVGGEPTAYVCRHFVCDAPTTDAGELAGKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZER7</accession>
    <name>A0A7K2ZER7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000762">
        <property type="protein sequence ID" value="MYW30799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029839944" evidence="1">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="45"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="21418" checksum="64957FD80E57F9C2" modified="2021-04-07" version="1">MNRVLVSAAVAAVVVGGVAVAVLPPDRPEQTGYRMSDRGVLTIDAKDRPKVPDIRGKTVEGKPFRLSDYRGKTVVVNAWAFWCGPCRLEMPMLVDFEKSMKDKGVVLVGINHGSDIGASKTFVREFDVTYPNLHDPLGKSTLDMPKGIIQSRGVPYTFVIDARQKVASSASGAINREMLDEMTAWAMKPSKEPIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEV6</accession>
    <name>A0A7K2ZEV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_16660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="351" mass="35912" checksum="BAF060A352E56377" modified="2021-04-07" version="1">MPASKPLLPDGARRAAAWCGVVLLVAGVAAVAIWLVVALKTAVTPVLLALLGTALLGPVHRWLIARRLNRSLAAGLTCAALVAVVGGAGYIVVTALVDSGDQIVRSLKDAGQWVIDHLDIGGNTDVDSLAENARNLVEKFGASAAGGLLSGISLVGTLVATSVLALLLTFFFLRDSDRAVDLAHAVAPRGTGDLVEAMGRRAFEAVEGFMRGTTFIALIDAVCITVGLLILDVPGAVGLGALVFVGAYIPYLGAFLSGAVAVLVALADRGFVIALWALGVVLAVQVLEGHVLQPVIQSRTVQMHPAMIMIALTAGASVAGLMGMLLAVPMCAAAFGVLGELRRRHSSPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF11</accession>
    <name>A0A7K2ZF11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multicopper oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_16675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000770">
        <property type="protein sequence ID" value="MYW30865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029816110" evidence="1">
        <location>
            <begin position="40"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="75"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="363"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="53484" checksum="CA0D35C99FCD5C8D" modified="2021-04-07" version="1">MLNRRHALQITAAAGAAALLPWDRLTGSSAPAATTTAAAAEAAPISPFAHAMPVPKVLAPVSSTKTSQLYELRMREAQVEIVKGLTSRVRTYGGTFPGPTIKASQGREVVVRQINELSVNTAVHLHGGHVRSEHDGLPMDTIVPGAERTYRYPNDQPAASLWYHDHAHHLEAENVYLGLHGLYLLSDRNERSLPLPTGAHDVPLVIRDARVEADGTLLYTRPSDCPHMLVNGKERPYFKVAARKYRLRIYNACANRYFKLRFADGAAFTQIGTDGGLLEQPVTRTELLMLGGERADIVVDFSRYREGSSIVLENTGALSTERPEVMRFDVGRATADHSYVPRRLASAPPVLPRRTVQRDFEIRTFPAMTINGLSYDPERVDVTARLGATEEWTIRNVDVPAAPGSPDFHLWHSFHTHLTFFRVLERNGQRPGIRDAGLKDTVTLGPGETVKIAMTWGPFTGEYVYHCHQLGHSSGGQMGRIDVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF30</accession>
    <name>A0A7K2ZF30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000790">
        <property type="protein sequence ID" value="MYW30909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="51" mass="5440" checksum="20345303B54D4ACA" modified="2021-04-07" version="1">RRLAAAGQVEAVRARPLPATASAHGRITLPEVTADPDIALLRRLRDALEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF57</accession>
    <name>A0A7K2ZF57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000793">
        <property type="protein sequence ID" value="MYW30915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029447195" evidence="2">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="6860" checksum="6BDF71F61EB25035" modified="2021-04-07" version="1" fragment="single">MRTLSVPARWAAVTALTIAASTGCMSVGDDGTRPGPSGSTDSKGRVIEPNGETVAGSGGAGHRGGDAHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFI8</accession>
    <name>A0A7K2ZFI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000822">
        <property type="protein sequence ID" value="MYW31045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="16697" checksum="7BE8D5CAA0762BEA" modified="2021-04-07" version="1" fragment="single">MSAAGHPRDVVIVGASLAGLRAAETLRAEGFTGNLTLVGAERHAPYDRPPLSKRFLTGQPPAADTALPVPDGLRARWRLGQAAVRLDPYSRIVTLADGTGLPYDGLLIATGAAARSGAAPGEPGPEQGVFTLRGRDDATALRAALTPGRKLLVVGAGFLGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFK3</accession>
    <name>A0A7K2ZFK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000836">
        <property type="protein sequence ID" value="MYW31079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029775138" evidence="2">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="14824" checksum="D644419A22A857E4" modified="2021-04-07" version="1" fragment="single">MICALGAALCYGTASVLQAIAARAATRPDSGAGVDPALLLRAVRQWRYVAGLALDGLGFVLQIVALRALPIYAVGAALAASLAVTAVVAARLLAVRLSTAEWAAVAVVCAGLGMLGLASGKEGDLPGPEWLPWAVPAAALGVLVLGAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFK7</accession>
    <name>A0A7K2ZFK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000829">
        <property type="protein sequence ID" value="MYW31065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="210"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="383" mass="40687" checksum="447460A2B0549494" modified="2021-04-07" version="1" fragment="single">MARSVYVTGIERGDGRQVVELGVMELLTRQVDRVGVFRPLVHDGPDRLYELLRARYRLSQSPASVYGLDYHEASAVQAEKGTDELVSRLVDRFHQVAREYEVVLVLGSDFAATQLPDELALNARLANEFGASVIAVVGGKGQTAESVRAETRNAYRAYAGLGCDVLAMVVNRVAPEDRAVIAERLAARLPVPVSVLPDDPALSAPTVAQVTAALDGTVLLGDDAGLARDALDFVFGGAMLPNLLNALTPGCMVVTPGDRSDLVVGSLAAHSAGTPPIAGILLTLNERPGEEILTLAARLAPGTPVVSVAGGSFPTAAELFTLEGKLNAATPRKAETALGLFERHVDTGALLERISVARSGRVTPMMFEHELLEQARSDRKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFK9</accession>
    <name>A0A7K2ZFK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_18030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000856">
        <property type="protein sequence ID" value="MYW31122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="34167" checksum="F99E58520D6F7822" modified="2021-04-07" version="1">MTEAIVLDGVHKRYGEKRALDGLDLTVGAGTVHAVLGPNGAGKTTAVRIMSTLLRPDAGRVTVAGLDVRERASGVRRRIGLLGQHAAVDEQLGGRQNLEMFGRLYHLGARRAGTRADELLERFGLADTGRKAVKQYSGGMRRRLDLAASLITEPAVLFLDEPTTGLDPRGRAEVWDAVRSLVGGGTTVLLTTQYLEEADQLADRVSLIDEGRVAAEGTSDQLKALVGGDRIDVVLRDAARLAEAAALLGSPDALRDPDRRLVSAPAPDRMAALTGAVRALQEAGIEAEDIAVRRPTLDEVFLSLTGRTSGEQAVRETEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFL2</accession>
    <name>A0A7K2ZFL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="244" mass="25266" checksum="5115CD606AC37DCB" modified="2021-04-07" version="1">MDAPHGPDIDYDALRRLLAPDRGPGSSPGAGPSPADRTAAGDLAVSVLRAVAEGRRSLSAVRHPLGFLCLPVLRDGAKGVCVHLFGAGTGGGGAGGEGDAPLVHAHSWSLVSLVLFGQVTNHSVRVVDDPVAPTHRVYEVRSGPDGTDEVRRTARFVRGVPDGFGHSTTGDVYVVRPGEFHATVVADGRPAATLVLGETQPGSKDMSLGLLSGEGHRSVREICGREETVVAVRAALRRIDATDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG66</accession>
    <name>A0A7K2ZG66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3696 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000906">
        <property type="protein sequence ID" value="MYW31354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030730785.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000906.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022532">
        <property type="entry name" value="DUF3696"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014592">
        <property type="entry name" value="P-loop_UCP034888"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12476">
        <property type="entry name" value="DUF3696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034888">
        <property type="entry name" value="P-loop_UCP034888"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_15" evidence="2">
        <location>
            <begin position="269"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3696" evidence="1">
        <location>
            <begin position="346"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="396" mass="42865" checksum="CF903DCCA8AB0550" modified="2021-04-07" version="1">MIDRLTLHNYKAFQHAELPLGPLTLLTGLNSSGKSSVLQSIGLLRQSYESGDLALSALTDEERRAGRRTNVSGRGFLLNGELVGLGTGEDVLHEDFTEDEPRIGLAVDEGAYHYGWTAAYEAEQNLLPLADADLPDTSEGERERPAGPEAVTPAFLTAPFQYLHADRISPAEFYPRDHQAAIGRGFLGVRGEHTVNYLRHHREDPVPEGPLRHPKAASDLLIDQAAAWMGDLCPGVDIQADAIKGTDAVSLSYGFRGTLGATKRRRPGNVGFGLTYVLPIVVACLSARRGALILLENPEAHLHPQGQTQMATLAASAAAQGAQVIMESHSDHVINGVRLAVKQGRITPEQAVFHYFRGDGTGVDFVSPRVDADGMLDQWPPGFFDELENTLDQLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGJ6</accession>
    <name>A0A7K2ZGJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1524 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000929">
        <property type="protein sequence ID" value="MYW31483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029800052" evidence="1">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="104"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="22882" checksum="87444D36C80D0CD0" modified="2021-04-07" version="1">MFGIYARRSAVVAATATLAATSVLLTAPTAQAALPTPVSAATARTYLGQLTVGAEGSSSGYSRDKFPHWITQSGTCNTREVVLKRDGTNVQQDAACAAVSGSWYSQYDGATWSAASDVDIDHMVPLAEAWRSGASSWTNAQRQSFANDLTRPQLIAVTDNVNQAKGDKDPAKWMPPRAAYKCTYVRAWVHVKHYYGLSVDSAEKSALQTALNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGN4</accession>
    <name>A0A7K2ZGN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hyaluronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_20130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000939">
        <property type="protein sequence ID" value="MYW31521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="3">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="500" mass="54116" checksum="E57512FCCA39172D" modified="2021-04-07" version="1" fragment="single">EALRALRAPDRADLPTGGYRIASGQVAGRATVALDGLGEDGLFHAVQTLRQLVRGGSVAGVVVRDWPGTAVRGMAEGFYGQPWTQEERLAQLAFMGRTKQNRYLYAAGDDPYRLARWREPYPALKRADFRELAQKAEAEHVTLGWAVSPGQAMCMASDQDVRALTRKIDAMWALGVRVFQLQFQDVSYSEWHCDLDAETFGSGPKAAARAQARVAGAVARHLEERHPDAAPLSVLPTEFYQDGATDYRTALAAELDDRVQVAWTGVGVVPKKITGRELSGARTAFRHPLVTMDNYPVNDYAQDRIFLGPYTGRDPAVASGSAALLANAMEQASASRIPLFTAADFAWNPKGYRAEESWQAAIDDLAGGDAEAREALRALAGNSADSVLGSAESAYLQPLFAAFWQSRAAAAPVRDRAARELRAAFTVMRQTPDRLATPAEGRLADEVRPWTEQLARYGHAGELVVDLLQAQAAGDGAAAWRTQLALEPLRQGIAAAKATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGW4</accession>
    <name>A0A7K2ZGW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="2">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_20475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000967">
        <property type="protein sequence ID" value="MYW31587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="3">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="TilS" evidence="4">
        <location>
            <begin position="138"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22810" checksum="983BD2C4FC212A69" modified="2021-04-07" version="1">ERHGAAAVLLGHTRDDQAETVLLGLARGSGIRSLSGMAAASGPAGRYRRPFLQLDRQTARKACLVQSIPVWDDPHNIDPAYTRSRLRHEGLPALEKALGKGVVEALARTAQLSRDDADALDTWAAEAELAVRDEAGGLECAKLYVLPPAVRRRVLRRAVIEAGAPAGSLFARHLEEVDRLITGWRGQRAINLPGRVEARRQGGRLVIRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH36</accession>
    <name>A0A7K2ZH36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000978">
        <property type="protein sequence ID" value="MYW31652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12890" checksum="F3AC83BCF813EB3F" modified="2021-04-07" version="1">MPDAVRTAAVRAVLIMSLTIIQAMVAFLSTLTGSWLAFPMVLSSVASTVVATWAVLDVWVTRQVWNQRHGVVSEPSSTARQMRRERRRAQRAARAAERDEAGGRIRGRRSAGDLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH94</accession>
    <name>A0A7K2ZH94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_20690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000974">
        <property type="protein sequence ID" value="MYW31629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="33308" checksum="7AA71282824A0632" modified="2021-04-07" version="1">MSTPVRTIPPAPHAPAAPSPDARPAPRPVRKGRWYGRTAANLVVGLSALYALLPLLWLLAASTVDSEALFASDFFSLSNFALFDNIKALLVQDDGAYLRWYGNSLLYAVGGAAVGALISTAAGYVFDKFEFAGKRALFALILVSVMVPATVLALPMYLLASDLGLANTVWSVLIPVLFNPFGVYLARMFSASYVPGEVLEAARMDGAGELRSFLSVGLRMIAPGYVTIFLFQLTAIWNNFFLPLVMLSDESLYPLSLGLYSWNAAAPINPDYYPLMVIGSLLALLPLVIAFLLLQRYWRSGLTAGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHI5</accession>
    <name>A0A7K2ZHI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">GT040_21530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001016">
        <property type="protein sequence ID" value="MYW31788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="14"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="18"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW31788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="23734" checksum="1E3165234EA05AC4" modified="2021-04-07" version="1">MSTTVETVSSAVIVAIDGPSGTGKSSTSKAVAAKLGLSYLDTGAQYRAITWWMLTNGIDVNSPAEIATAAAKPVIISGTDPTGPTITVDGEDASGPIRTQEVTSKVSAVSAVPEVRTIITELQRSIAAGAVGGIVVEGRDIGTTVLPDADLKIFLTASPEARAARRSGEVKGSDLAATREALIKRDAADSGRKTSPLAKADDAVEVDTTDLTLQQVIECVVTLVEEKRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHP0</accession>
    <name>A0A7K2ZHP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="8">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nagA</name>
        <name evidence="8" type="ORF">GT040_21980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001033">
        <property type="protein sequence ID" value="MYW31871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="52"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="306"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="385" mass="40393" checksum="ECFB8E398010C2AD" modified="2021-04-07" version="1">MAGRAADSTVLAGARVVLPTGTVEDGRVTVESTRISDSAPEDARVIDLPGHWVVPGFVDMHNHGGGGASFTSGTVDEVLHGIHTHREHGTTTLVASTVTGEMDFLAQRAGVLSELVEQGDLAGIHFEGPFISPCRKGAHSEQLLRYPDPAEVRKLVDAARGAARMVTLATELPGGLDSVRLLADLGVIAAIGHTDATYEQTVEAIDAGATVATHLFNAMPPLAHREPGPIAALLEDDRITVELINDGTHLHPATLELAYRHKGAGRVALITDAMDAAGFGDGLYDLGPLAVEVRDGVARLVEGGSIAGSTLTLDTAFRRAVTIDRIPVEDVVRSISANPARLLGVDDRVGSLEPGKDADLVVLDADFVLAGVMRKGEWIIEPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHR4</accession>
    <name>A0A7K2ZHR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_22110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001042">
        <property type="protein sequence ID" value="MYW31896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="306" mass="33690" checksum="752F5F45114354AE" modified="2021-04-07" version="1">MSTQTATPDAPPAPAPARRPSPPRRPRRTGQLTSKVAVNAVLAVVAVYTLMPLTWLLIAATKNYRDLFATNPFSLGDFHLLSNLEALFAYNDGLYGRWLLNSLLYTLVAAIFSTLVSVACGYAFDKYVFRGKEKLFGVVLVGVLIPSTVVQLPLYLMASELGLVDTYWAVLIPSLVNPFGVYLARVFSEGYVPGEVLEAARVDGAGELTTFTKVALPMLAPGFVTIFLFSFTANWNNFYGALMMLNDERLYPVNLGLFMWNQNVYQQPELYPLVIIGSLVAVVPLIIAFLCLQRFWRSGLTAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI04</accession>
    <name>A0A7K2ZI04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001063">
        <property type="protein sequence ID" value="MYW31983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029548468" evidence="1">
        <location>
            <begin position="44"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="297" mass="31504" checksum="25C3971DB8626EA6" modified="2021-04-07" version="1">MLPWFRAARVPRTRGVFAAFLLAVTLLVAPTATATAAAPTATAATSRGWNDYSCKPSAAHPRPVVLVHGTFGNSVDNWLVLAPYLVNRGYCVFSLDYGQLPGVPFFHGLGPIDKSAEQLDVFVDKVLASTGAPKADIVGHSQGGMMPNYYLKFLGGAPKVNALIGLAPDNHGTTLLGLTKLLPYFPGVEKFISDKTPGLADQVAGSPFITKLTAGGDTVPGVRYTVIATKYDQVVTPYRTQYLDGPNVRNVLLQDLCPLDLSEHVAIGTIDRIAFHEVANALDPARATPTTCSSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI54</accession>
    <name>A0A7K2ZI54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001071">
        <property type="protein sequence ID" value="MYW32040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="22387" checksum="8F9D28CB9882A29B" modified="2021-04-07" version="1">MEPTTLTTRRLLLRPFGPQDTYKVHAACQDPDIQRWTVIPSPYRLTDAELFTAKLAPAGWRDDSAYSFALVLPETGALVGALSIDRRSRPGTYEVGYWSTKEHRGRGYVTEAVLGSARWAFGALRADRLEWRAEIGNLASRAVALRAGFHLEGDQRSGLLNKGVRRDAWTAALLPSDLGLPGAHPYLPERHAERPGGVPDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI68</accession>
    <name>A0A7K2ZI68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511751.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001061.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="26907" checksum="7D36AC03DA439B64" modified="2021-04-07" version="1">MLTVDFTRFPLAAGDRVLDLGCGAGRHAFECYRRGAQVVALDQNGEEIREVAKWFAAMKEAGEAPEGATATAMEGDALNLPFPDDSFDVVIISEVMEHIPDDKGVLAEMVRVLKPGGRIAITVPRYGPEKICWTLSDAYHEVEGGHIRIYKADQLLARIREAGLKPYGTHHAHALHSPYWWLKCAFGVDNDRALPVRAYHKLLVWDIMKKPLATRVAEQLLNPVVGKSFVAYATKPHLPKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIC0</accession>
    <name>A0A7K2ZIC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001082">
        <property type="protein sequence ID" value="MYW32087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="454" mass="48124" checksum="70C5646906223C8D" modified="2021-04-07" version="1">MREAVRSGRLTAGTRLPSSRELAADLGVSRGLVTEAYEQLTAESYLRSGQGAGTWVSDGVRAAAHSVRDLAPRAPGARVDFRPGVPDLSLFPRTTWAATQRTVLGRLPHSSLGYPDPRGLPELREALAGLLARRRGVVADPERLVVCSGVAQATTLLGFVLREQGLSSVGVEDPGSPEHASLFAATGLRATPLPLDTEGVALGQLRRSGVRAVVTTPAHQFPTGIVYSAERRRALLDWAREADAVILEDDYDGDFRYDRAPVGALQGLDPERVVYTGSVSKSLAPGLRLGWLIAPATLTDRIVARKRTMDLGNPAIDQAVLADFIVRGAYDRQLRRCQRAYRERRDALVAALDEHFPGTVVSGIAAGLHIIARLPRRYGPEGAFLRRADRAGIALRPLSDCGDAGPEDGTVALVLGYAHLGAAEISRGVGMLAAAQEPGAQGPGAQESGGGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZII1</accession>
    <name>A0A7K2ZII1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001108">
        <property type="protein sequence ID" value="MYW32151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11145" checksum="1A483107DEA5D108" modified="2021-04-07" version="1">MRLGHPRAHCRVGVPEKGHRHAAAREHEMHALRHFYASILLGAGENIEALSLYLKHSDPGFTLRVYTHLMPSSETRARKAISAMCQAAGHAQEGPEATQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIJ0</accession>
    <name>A0A7K2ZIJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="15145" checksum="A31312556C10522B" modified="2021-04-07" version="1">MITDTTDETIRYTADVVLFADRHVLLIERGWDPFKNRWALPGGHVDKGESSLDASARELEEETGITVPVAELRQVGAFDAVGRDPRGRYVSVAYTATLPALVEPTAGDDATAARWWPLADLPDLAFDHAEIVAEAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIQ7</accession>
    <name>A0A7K2ZIQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_23930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001115">
        <property type="protein sequence ID" value="MYW32236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7292" checksum="83953AD878903614" modified="2021-04-07" version="1">APHAARALVGRRHVRVVPVSALLGALLVVVSDTVGRTVIAPAQIPVGLLTAVIGAPYFIWLLWRSRSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIT9</accession>
    <name>A0A7K2ZIT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3416 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001122">
        <property type="protein sequence ID" value="MYW32262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3416" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14641" checksum="C07D00F7C11474F9" modified="2021-04-07" version="1" fragment="single">MIGRIPVLDVRPLVDCGRRPAKAVVGETFEVTATVFREGHDAVAANVVLRDPSGRVGPWTPMRELAPGTDRWGAEITPDAEGRWTYTVEAWSDPVATWRHHAAIKIPAGIDTDLVLAEGAALLERAAAGVPKKNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ52</accession>
    <name>A0A7K2ZJ52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family 16 glycosylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001133">
        <property type="protein sequence ID" value="MYW32289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029492027" evidence="1">
        <location>
            <begin position="43"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="44"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="31774" checksum="DB69FDA1F6E5F2E6" modified="2021-04-07" version="1">MTVHLPHNAVPSRSRRRRTALYAASLLCCSALLATLPGGASAAPGSAPAPGPAAVSFEDNFDGPAGAAVDGSKWQLETGDNVNNHERQFYTGGNDNAALDGQGNLVITARKENPGNYQCWYGTCEYTSARLNTAGKFAAAYGHVEARVKVPRGQGMWPAFWMLGDDFGNVGWPQSGEIDVMENVGFEPGTVHGTLHGPGYSGADGIGAGYTLPNGAAFADDFHTFAVDWAPDSITWSVDGNVFQRRTPADLGGKEWVFNKPFFLILNLAVGGYWPGDPDGSTPFPSQLVVDYVRVTTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJK1</accession>
    <name>A0A7K2ZJK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type-I PKS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_25380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001195">
        <property type="protein sequence ID" value="MYW32511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="726"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="763"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1116" mass="120403" checksum="680D1E84AA43436E" modified="2021-04-07" version="1">SPARAVGDHSAGSEPGDRLRARVEAVALDVLAEALDIPRTRIGRDEPFSNYGLDSIFAVNVARTLGGTLSIDLDITVLFEHNTLAELGEFIVSEYAEELRDAHPPEPAPPEGVPDPVQPDPRPRPQAELDEAALDGMAIVGMAARFPGADDVDEFWRIVEHGRRCITTPPEKRADWASYDGDEAAALRGGFLEGVHAFDPLFFRMSMTEARQVTPELRLLLMTSWNAVEDAGYRPAELRNRPTGVFVATTQSEYRPAVRDLLSLPSPAMVPNRISYLLDLTGPSEQYDTTCSSSFVALHRAIRSIRDGECEQALVGGVNLVMSPEGFGGMRAAGMLSPSGDVRPFQEGADGTARSEGVAAVLVKPLRRALEDGDFVHCVVRGTGVAHGGRGVSFTAPNIRGMKSAVAHAYADAAIDPGAVEYIETHGMSSMLADSAELAALGAGPRGEDDEEAVTYLGNVKPCIGHTEVVSGLAALVKTAQAMRHGVIPAIPGFGQLHPDLSLKGTRLRIATRNLPWPERTDAAGRPLPRRAGMHSFGIGGVNAHVVLERHTAPANLDDEPGAQALVLSARSADALRERARRLIHRLGQADPRSWADIAYTLQVGREAMSCRLGFVARSTDEAARVLGGWLDGDPDALARVAFADGVGPAADAGHDGQPTRLDDVAEHWVAGTSIDWELMHRGARRRRVPLPGYPFARLTCFAEQAPPSDQAAHTGDGPPGGADGVDGEDREAFVADLVASVLGLPRHEIDGTRSLADYGLNSLLLVAMLGRISSAFPGFRPEWWQPHDTLNDVVARLPEAQVRSSGVSAPELVRLNGATEGRPVFWVHGALAGVESYRTIAERIDRPFYGIQARGLLTEDPPIEGITAMAAYYTEVIRSVQPEGPYDVGGFCLGGIVAYEVTRRLQEQGQDVASLTMVDSPDETGLAKSNANGFQSARSAALQVVNSLLWPAGETDPAVLRARLVHRDEVAEERDEDAFVVRLAEAAAERGLAMRPDRTAWFVRRNMAIQLAYRLGEHTIRPLPRPEAVVCTYFRNRRGLFLGEAEPYFQLAGETFSLDQVNYRQDWERELPGLRLVEIDAANHMTILNDAAPLAAIEETCLALYASDENGASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJS9</accession>
    <name>A0A7K2ZJS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">GT040_25870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="WWKE01001203">
        <property type="protein sequence ID" value="MYW32606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513622.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001203.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="130"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW32606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="22974" checksum="C9679A24F7538962" modified="2021-04-07" version="1">MRIHVVDHPLVAHKLTTLRDKRTDSPTFRRLADELVTLLAYEATRDVRTEQVDIETPVTPTTGVKLSHPRPLVVPILRAGLGMLDGMVRLLPTAEVGFLGMIRNEETLQAETYATRMPEDLSGRQVYVLDPMLATGGTLVAAIRELIKRGADDVTAVVLLAAPEGVEVMERELAGTPVTVVTASVDERLNEHGYIVPGLGDAGDRMYGTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJY7</accession>
    <name>A0A7K2ZJY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_26100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001213">
        <property type="protein sequence ID" value="MYW32651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="280"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW32651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="515" mass="55529" checksum="F10FDC58B0A22F83" modified="2021-04-07" version="1">MTERTKRSLRAGLRWTSLRLRLVVVFALVALTAAVSASGIAYWLNREAVLTRTQDSALDDFRRQMQETAAALPVRPTHNDLQRAAEQMASGGPGYNVLLVDERERGKPITGFSALDDFTLDYVPDSLQKQVARKQPLDSNNEHEYHLFWQRTSIAGTPYLVAGTRIIGGGPTGYMLKSLDQERQDLNSLAWSLGIATTLALIGSALLAQAAATTVLRPVQRLGDAARKLGEGKLDTRLTVSGTDELADLSRTFNRTASSLEKKVADMSAREESSRRFVADMSHELRTPLTAITAVAEVLEDEADSLDPMIAPAVHLVVSETRRLNDLVENLMEVTRFDAGTARLVLDDVDVADQVTACIDARAWLDAVDLDAERGMMVRLDPRRLDVILANLIGNALKHGGSPVGVRVRTEGEELVIEVRDHGPGIPEEVLPHVFDRFYKASASRPRSEGSGLGLSIAMENAHIHGGDITAANSPDGGAVFVLRLPRDASELTGGGAAGADGRGGDDDSEDGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKB2</accession>
    <name>A0A7K2ZKB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001251">
        <property type="protein sequence ID" value="MYW32783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="286"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118007" checksum="9E7A4164C6351D08" modified="2021-04-07" version="1">MSITPTYPGDRTVAVFGSLQGSGVLLADRLILTCAHVVGSGPALVAHPAVRDRMPATVAWMDDRLDVALLEAAGPVQPVLPARLGVLDTREAIPGCEITGFPRVQRYGPDQRLEADQYMATVLPMAGRVRDLLVCDLDGAPAVRPGDEHPALSGLSGGPVFVGDVLLGVVRRIPQQREGRRVDCVPLSPSLAAELFVQAGGRGALLREERVHGNFARDLRYEVEYAQALGVAYRRTKIFGLDELSRHDSEWDLDTAYLSLEAQAQGRAAPGPPLPQRIDTLLTGRPRVLLRGDAGAGKTTLLWWLAAHASAHTLDDDLAPLNGLVPFVVPLRTLRARGGGFPGPAELSGAAGLVVDAAPEGWAGRVLESGRALLLVDGLDEVPPEDREQAHDWLSQLLARYPETRCVATVRPLAVEPDWLRSEGFAELGLLPMRNEDIQAFVGSWHRAARLSEPDDAGRLDELERDLALQFDQNPTLRDLARTPLLCAVICALHRRRDGFLPETRWSLYRSALEMLLGHRDRRRRIGDPEGVDLSVEEHTQLLQRIAVWLVREGQSEFTREQALRQLGRALAGMERVSAQGPPAKILTHLLNRSGLLQERTDDTYQFIHRTFQDYLAAKELVEDDHLNELLRHADEETWQDVILLASGHCGRRELAVLVRGLLDAGLRHEADTVERTTVHVLAALCAQHATWLDHPVREAVRESTAALFPPRTGGQVASLARLGPAALAFLPDPRQVPEEDPRQQHVGQLIVTIGGAPAVPHARDWILALPGLSHCFANAWERFPPEGYAAQVLAHCDLASTVLTVSDRKHLRALRHLPNVSALSLRLDLPDAEIGAALEGTRLERLFLRKTTRLTGLAFLSAAANSLSALTICLSPAIRDLTPLAGLHKLGLLLLEAERTRPADLAPLADIPALSRLRLSQLGVERLSEIAANPRVTSLTVTSGRPLVLDGLGAWKSLRNLKISKLAALDDALDALREHSRITVLGFTAFPWAHLPTRSIRVPSVEKLSVPAPDHRGDLGMLRPLFPGVTDLTLHASGLHVLDLTPLHFWPGLRVRVTGLSRQRLIGAEELGSRLNASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKD4</accession>
    <name>A0A7K2ZKD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BlaI/MecI/CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001251">
        <property type="protein sequence ID" value="MYW32788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="17215" checksum="6804E8C5D354C3E0" modified="2021-04-07" version="1">MTRVWQWNRPVTVREVLEDLQQERSIAYTTVMTVMDNLHQKGWVRREVDGRAYRYTAVSTRAAYSAALMNEAWSQSDNPAAALVAFFGMMSPEQREALQDAVRMVSPNPVDNSADNPLSGPAGNPAGGPVANPEDGPSEPAAAAAEGSTPADGAEPRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKE8</accession>
    <name>A0A7K2ZKE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH family NRPS accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001256">
        <property type="protein sequence ID" value="MYW32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="9418" checksum="06CBF68E271B08E7" modified="2021-04-07" version="1">MSDHTESVYRVVLNDEEQYSIWQAERELPVGWRSEGTQGSKEECLDHIGRVWTDMRPASLRHRMESEAAEAATGRAGCQSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKH1</accession>
    <name>A0A7K2ZKH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_27065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001259">
        <property type="protein sequence ID" value="MYW32835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="295" mass="31253" checksum="26910C9D579F983C" modified="2021-04-07" version="1">MTISHAPPDPAVALEKTPASGSRTSPGLEPIVPASVRRARLRSVPRWLRRTVGPLLLLALWQVFSATGVLHPDVLASPGTIARAGGDLIADGTLPAAMGVSLQRVAVGLVLGGVVGTVLALVSGLSRLGEDLVDATVQMLRTVPWVGLIPLFIIWLGIGEAPKVALIALGVAFHLYLNVYAGIRGVDAQLIEAGESLGLNRWGLVRHVVLPGALPGAMTGLRYSLATAWLALVFSESINADAGIGFLMNQAREFFRTDVIVVCLVVYAFLGLTADVIVRTLERLLLQWRPTFTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKH2</accession>
    <name>A0A7K2ZKH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2236 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001261">
        <property type="protein sequence ID" value="MYW32840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="entry name" value="PTHR36124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="48"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="302" mass="34712" checksum="696B4D65C6A138BA" modified="2021-04-07" version="1">MVQRYDRLKEIQRLDPERDFLEIYRLTVTYEFPWDITRALELALYRTYAVPSIGRLLDETAELTARSQKRYDDTALLLDTVVEHGFDTEEGRTAVRRINQMHRSYDISDDDMRYVLCTFVVTPKRWLDDYGWRRLSDHELRAFAAYYRTLGARMGIKDLPQSYEDFERTLDTYEHEHFGWDAGARRVSDATLALMGSWYPAPLAPLVRGASLALLDDSLLRAFRYERPGAVARGLTRGALRLRARAVRLLPPRRTPHYARQNPEIKGYPDGYDVAALGTFPTPGVRGCPVPGHRPPSGVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKI0</accession>
    <name>A0A7K2ZKI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001263">
        <property type="protein sequence ID" value="MYW32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="478" mass="48732" checksum="95CBCF04B273F5E8" modified="2021-04-07" version="1">MSTERPDNDVTGPRRRRTPLAVASVAAAVLLAGGGAAYWASTASGDGGAADNGSASRDKAPVLALDSVAEAGPATPGDPGTPPPGIAPGEPDPNGPPVVYRAADQLPDGPDEAAVHRATGTVDSAEVARLAKALGIPGTPRTVDASWVVGDEDGPGALLKVTKQAPGTWTFARTTPTKPCDPGKMCANQSPPEADGQPVSEKAAKAAAVPVLKAVGQDDAALTAGQLMGDVRVVNADPKVDGLPTYGWSTGVQVGPDGKVAGGSGQLKALEKGDTYPVVGAEDALKQLNEAGKAKGDASRDIGGCATPVPLEGEPKPSDPQCVPSNGKRAPVTQTVEHAEFGLALQYVDGRQTLVPSWLFHVRQGTGGPESTVTRIAVAPEFVEKPTAPTPSGDRKATSYAADGRTLEVTFWGGVCSTYTASAEESAGQVRVTITEEKQKKGACIMIAKELKRTVTLEKPLGDRTVIDAESGATVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKV1</accession>
    <name>A0A7K2ZKV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsf</name>
        <name evidence="10" type="ORF">GT040_27745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001298">
        <property type="protein sequence ID" value="MYW32963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030569540.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001298.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="73"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="278" mass="29710" checksum="3C959ACBAFCFFBDC" modified="2021-04-07" version="1">MANYTAADVKKLRELTGAGMMDCKKALDEADGSVDKAVEALRIKGQKGVAKREGRSAENGAVVSLISEDKTSGVLLELKCETDFVAKGDKFQAVANALAAHVAATSPADIAALLASEIEPGKTVQAYVDEANANLGEKIVLDRFAQFTGDFVSVYMHRTMPDLPPQIGVLVELDKADADLAKGIAQHIAAFAPKYLSREDVPAEVVEAERRVAEETTRAEGKPEAALPKIVEGRVNGFFKEATLLGQPYALDAKKSVQKVLDEAGVTLKRFSRIKVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL28</accession>
    <name>A0A7K2ZL28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2079 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001308">
        <property type="protein sequence ID" value="MYW33043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="499" mass="54563" checksum="FF105B30E43208EB" modified="2021-04-07" version="1">MLELNKSGTDPVEEAGRLLPTQRTGPDPATAERVPLRPYLITGAVLCGLYFLYSYLQYSRFGSPSWDLGIFEQEVRAYADLRAPIVDIKGPGYLILGDHFSPIVALLAPLYWLWPSAESLLFAQAAFFALGAVIVGRTAQQLLGGRSGLCVTVAYGLSWGIQEAVKSDFHEIAFAVPLLALVCRALLLKRWTAALLWSLPLVLVKEDLGATVAVVGFLLFVYGRRLQGALLAAFGVAAFVVTLMVLIPAASSAGTYDYWQKIDKNGEQDVSMLDSVLGVLNSSTKIEMLVFLIGITAFMALRSPLTLLIVPTLGWRLLSQDSNHWGMVWHYSAILMPVLFLAMADGVRRSRDSERPWLASYAKTVVPVSVAIAVAMTQHLPLRDLLRPDSYSTDARTEAARAALKAIPAGARVETDITLMAHLTSDRTVYWIGGAPGTAPDIVAINLDFGWARPIQDPVAYAEQLHPEARYRLKHRGGSFVVMERTTPEPAEIPGVRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLA0</accession>
    <name>A0A7K2ZLA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_28580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001327">
        <property type="protein sequence ID" value="MYW33121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="469" mass="49897" checksum="F7139F391A000D3F" modified="2021-04-07" version="1" fragment="single">MTGSHATPGKTTRPDQQGRGSGLALLVIASCQLMVVLDITIVNIALPHMQKSLGFSTENLSWVVNAYTLTFGGLLLLGGRLGDILGRRRVFIFGVLLFVLASLLGGLSQESWQLLAARALQGVGGAIASPTALSLITTTFREGPERNRAFGVFAAVSAGGSAIGLLAGGVLVEWLDWRWVLFVNVPIGLLIAFATPRYIRESERHPGHFDVVGALTSTVGMVLLVYGFIRASEDGWSDPLTLGSFAAAVVLLALFIFIESRSRQPITPLWMFRDRNRAGTYAMMLSLAAAMFGMFFFLTLFVQNVLGFSPLRAGLAFLPVSVIIAVGAGFASQMLPRWGPKPFMVTGALLAAIGLGWLTLTDVHSTYLGSILGPMLVFGLGMGMQFVSLTLMAVSGVAPREAGAASGVLNATQQVGGSLGLSILVTMFGTASRHEATDQVPRFLEQATPAQLLQFRRTGELPPPWGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLE9</accession>
    <name>A0A7K2ZLE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001348">
        <property type="protein sequence ID" value="MYW33171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="234" mass="25792" checksum="2D70300AFAFAFD4D" modified="2021-04-07" version="1">MDSTGTESSTGTGAEKDKAAAGLTKATPAATPAPTAAAAPDIQSHDTFVIRKTLSLTAGEYVVSVARPDGSEGEPVAYAREKRLSLRGQVTLYTDASRKSVLAAFKGRDHEVGYMYDVRDASGQPFGSFHEDAGASFLRRTWQVRQPGTMKLTGREQSRVVAFVRFVWEFVPYLEYVPFIWPYRFQYTESGKPLMTVTKKLGLHTRYVLEILAPDIDRRLAIAHTLALDALEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLV1</accession>
    <name>A0A7K2ZLV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1524 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_29590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001369">
        <property type="protein sequence ID" value="MYW33306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029881684" evidence="2">
        <location>
            <begin position="33"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="3">
        <location>
            <begin position="133"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="28221" checksum="C2E98AE856FA08BF" modified="2021-04-07" version="1">MISRRTYRAAALPALSALVVLALAGCDPDDLAAESGGSTSGSTSSGANGGGAQSAEGFGVSPLDNPDGTKPGLAPLTGDADRAAARKIIEKVATKGRGPKTGYERSKFGSAWKDGIDGIPLARNGCDTRNDLLARDGKDIEHRSGSNCVVVSLKLKDPYTGKSIDWRKQQATKVQIDHVMPLSYNWQMGAARWNETKRQQIANDPLNLLPVDGPANSAKRDSGPAAWLPPYKPVRCSYAVRFAQVSLKYDLPVTAPDKQAMLAQCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLW1</accession>
    <name>A0A7K2ZLW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rplK</name>
        <name evidence="11" type="ORF">GT040_29800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010058817.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001382.1"/>
    </dbReference>
    <dbReference type="GeneID" id="66955039"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW33345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15047" checksum="CFB52E6767758122" modified="2021-04-07" version="1">MPPKKKKVTGLIKLQINAGAANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGMVVPVEITVYEDRSFTFITKTPPAAKLILKAAGVDKGSGEPHKTKVAKLTAAQVREIATTKLPDLNANDLDAASKIIAGTARSMGITVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLW9</accession>
    <name>A0A7K2ZLW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="725" mass="78827" checksum="F079917567001999" modified="2021-04-07" version="1">MSPDAKERPGDNSAAVDAPPSDADDDRRPDQSAAEGAGDRPQDAWAARRDLWDHTPRAMGFGESARIDGGVLGGVNHGIGGGIFHGAVHLGATHVHYRLGGRGAAAPSGEVPAATLNALAESFADPGSSFAELLDRLREERVLVLEGPQSAGRRTAALMLLHRLGATPVHVIARDTRFGELVPEREGERPGEGQGYLLCDPVTEPQRPLREVDLLALRDRLIDQAAYAVITVGLKAHMEDVGACGWQPPPPSDVLHAHLRALLGRTDAAELLALPLVTEFLCREHQPRETAEFAAVLVQYLAGETGDRHAEGFSLLKLEEQVREWFEEDDAALHLREKAFLIALAVFDEGPYALTAEVSDGLYAHLQRTADSRLQAAVPVFGTHIEKRIRLARARRYEDEEPTEWGPVLQTKAAYRDKRAAFILLREVWTGHPSARPALVRWLQDLSKDGRPLVRTRAASTAAVLALTDLPSAMALVIQPWASSVSFGPRSVAVSALALAHSIGTPNVPRILDSWCDSATPHLRWVAIRTHGLIGPERPVETLTALRAAARHEEHDAASVPDDRPEEDETELAVVLAESVELLLLSSAQDQVLAELLRTLHHGRYAFDLAVGGFLGACRRTGGDEPDGRPLLLDSNAAAQMTELWRRALGDRFHRAKALETLRMWVLSAEHDAQAERCLALLLPALAEGAQEWRRIDHLLRTVPGEDPTSPPAVAGRLRAALAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMB3</accession>
    <name>A0A7K2ZMB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_30320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001396">
        <property type="protein sequence ID" value="MYW33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041673">
        <property type="entry name" value="TetR_C_23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17931">
        <property type="entry name" value="TetR_C_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="28510" checksum="6D1F1B48B03A97AF" modified="2021-04-07" version="1" fragment="single">MVKEEKNVQENGAAKPAKAAKAASSGKAAKSEQTRTLILETALRLFAERGYDRTTMRAIAQEAGVSTGNAYYYFSSKEHLVQGFYDRIAGEHAALVRPVLTGQAELADRIRGVLLTWLDVAEPYHRFAAQFFKNAADPESPLSPFSDESVAAREAAISIHRETLAGSSTKSDPELAPLLPELLWLMQMGLVLFWVYDRSPRAERSRRLVERTAPIAARAIGLSRFRVLRPLVRQVHALLVEFMPGASAGAEPRPGPAPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMG3</accession>
    <name>A0A7K2ZMG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosynthase chain-length factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001426">
        <property type="protein sequence ID" value="MYW33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="11547" checksum="110928E23316716D" modified="2021-04-07" version="1">VDVVFADAAGRRTEDREESEALAALFGPRGVPVTAPKTMTGRLAAGAGSLDVAAALLALRDQVIPPTTGVTEPAADCPVDLVTEVRPARLRTALVLARGRGGFNSAIVVRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMH8</accession>
    <name>A0A7K2ZMH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001433">
        <property type="protein sequence ID" value="MYW33551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="60"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="25262" checksum="47F20A3A3DB33D0A" modified="2021-04-07" version="1">MRLRLPRLSALRLPRSRRGRRLAVQGLMALCVLALLPATWMRLGADARVGTTADAPAREVAMVFGAGLWKGRPTPYLAHRLDAAAELYRTGKVKVVLVTGDNSRVEYDEPDAMRTYLTERGVPDDRIVSDYAGFDSWDSCVRAKKIFGVDRAVLVSQGFHIHRATTLCRSAGIDAYGVAVDEPRDATWYYGGTRELAASGKAALDALFRRDPRFLGPQEAGVTEALASATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMN7</accession>
    <name>A0A7K2ZMN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046193">
        <property type="entry name" value="DUF6221"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19730">
        <property type="entry name" value="DUF6221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10933" checksum="DB6C678CBE64B0E7" modified="2021-04-07" version="1">MTAALVAFLRARLEDDERVARACAGDGAWAVEDLEFYAPDLSDEVRAHAALHDPARTLREVEAKRQLLTIHHMVEDPQEMQDYCAECDLGRDKYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNC8</accession>
    <name>A0A7K2ZNC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">GT040_32375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="20769" checksum="7A0B789FBAE30F31" modified="2021-04-07" version="1">MTDMRPSQRMRDLGVVQQGAAILTEQARPFDLPAERDEAERVVDELFAAMDRIAQVHPFAKGMGLAAPQIGISRAAAVVQPPGDAPSIVLLNPRITESCNETDEHYEGCLSFFDVRGLVPRPMTITVETTAQSGETVTTAYERGLARLIHHEIDHLGGLLYTARLNAGVTPIPVEQYRQTGQAWAYERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNU6</accession>
    <name>A0A7K2ZNU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001521">
        <property type="protein sequence ID" value="MYW34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="272" mass="27384" checksum="C842BDD685FC54D0" modified="2021-04-07" version="1" fragment="single">MFGRTEQDEPTTATVPPQAERTQSTEPEPETTSAAGSTSETEASEPKPSEPKPSIPAPASPVAETTDGDAGAADLVAAAFDKAATAPTTPSPTPTVPAQGSGPDAEPVAERKAEPVAETVVEPVAEPVAEPVAESVAEPTAEPVVEPKAETATEAVPEPVVEPVTVEEPAAEPAKAEEPVEADEPVKAEEPAPAPVVEPVTAPAPITIDFDLDLDPEPAAEPETQAAPKPEAEPEAEATPAPEAEAAPKAAAPTEVNEAAATPEPAAAFPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP32</accession>
    <name>A0A7K2ZP32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Modular polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001528">
        <property type="protein sequence ID" value="MYW34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="63"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="17229" checksum="789CA7A307AA15C7" modified="2021-04-07" version="1" fragment="single">ELRNQLGTATGLRLPSTVVFDHPNPTALTAFVLGLVPGQDQAGAAPGKAAKARRGKRSGTADEPLAIVGMACRYPGGVRSPEELWDLVTSGTDAISGFPTNRGWDLERLYDQDPENTGTSYVREGGFLHDADLFDRDFFGISPREATAMDPQQRLLLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP63</accession>
    <name>A0A7K2ZP63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001548">
        <property type="protein sequence ID" value="MYW34135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="474" mass="50587" checksum="4B3F9D899672C45C" modified="2021-04-07" version="1">MPSHLFADRPAPQPPAHDAVDALIHRARRLRGDVEAVGRNTAVTEEDDPQARWQRALCDLAVQHLDNLDQHLGQLKAGPPAQRSADRDDRVSADGASAGSSANRVGSAEWNLLTDEVSWSEELYEIFGRPPGSPPLSLDDLPSVLLPDDQPKLTSMVTGCLVDGQPMDGEFRIVRPDGQVRTLHMTGEPVLDSEGCTASMWAVLRDVGELRRGEETVSRNRDSARRDEPVERPRHRTATEAQETVLHPWRGSLLLPAQGPGALDIAAHHLPSAAGGLIGGDWYDAMELPDGRTLLSVGDLSGHGLPATSALAMMLGALRGMAVAGIEPGALMGHLDHLLETSVRPALGSALCCRLDPATGLLSWAQAGHPAPLLFRDGTGRRLLPPEGALLGAASRIAYEQDEVRLLPGDVLVLHTDGLTRRGDPGVGPEQLLALAPRFAQARDAQECVRGVVEEFGGAERLDDACVLVARIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP77</accession>
    <name>A0A7K2ZP77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ureG</name>
        <name evidence="6" type="ORF">GT040_33570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001541">
        <property type="protein sequence ID" value="MYW34069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22158" checksum="289947CFE837AFA2" modified="2021-04-07" version="1">DATRPDGTRRALRIGLGGPVGSGKTATVAALCRELRDRLSIAVVTNDIYTREDAEFLLRNAVLPPERIQAVETGACPHTAIRDDISANLEAVEDLEETVGPLDLILVESGGDNLTATFSKGLVDAQVFVIDVAGGDDIPRKGGPGVTTADLLVINKTDLAPYVGSDLQRMARDAKEQRGELPVLFTSLTSTEGVGPVAGWVRAQLAAWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP86</accession>
    <name>A0A7K2ZP86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_34050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001551">
        <property type="protein sequence ID" value="MYW34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="119"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="505"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="584" mass="61171" checksum="CB1FDA410974A32B" modified="2021-04-07" version="1">MRKVLIANRGEIAVRVARACRDAGIASVAVYADPDRDALHVRAADEAFALGGDTPAASYLDMAKVLQAAADSGADAIHPGYGFLSENAEFAQAVLDSGLTWIGPPPQAIRDLGDKVAARHIAQRAGAPLVAGTPDPVAGSAEVVAFAEANGLPIAIKAAFGGGGRGLKVARTLEEIPELYDSAVREAVAAFGRGECFVERYLDKPRHVETQCLADRHGNVVVVSTRDCSLQRRHQKLVEEAPAPFLSEAQNAELYAASKAILKEAGYVGAGTVEFLVGADGTISFLEVNTRLQVEHPVTEEVTGIDLVREMFRIADGEELGYGDPAVRGHSFEFRINGEDPGRGFLPAPGTVTTFAPPTGPGVRLDAGVESGSVIGPAWDSLLAKLIITGATREQALQRAARALAEFQVEGMATAIPFHRAVVADPAFTADPFTIHTRWIETEFVNEIKPFAAPAEADAEDEAGRETVVVEVGGKRLEVSLPSSLGMSLARTGLAAGAKPKRRAAKKAGSAASGDSLASPMQGTIVKVAVEEGQEVKEGDLVVVLEAMKMEQPLNAHRSGTVKGLTAEVGGSVSSGALICEIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPC8</accession>
    <name>A0A7K2ZPC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001557">
        <property type="protein sequence ID" value="MYW34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="395" mass="42718" checksum="58736CC436AB1953" modified="2021-04-07" version="1">MAELYDFDTAIDRRGTWCIQWDGVADRFGVDGLLPFTISDMDFATAPEVLAALRARLDHGVFGYTTWQQDDFRSAVAHWYATRYGTEIDTGQLVYGPSVLNQLSQLLQMWTAEGDGVVAHTPTYDGFRKAITGLGRELRGVPVGDEEALVRELARPDAKVLVLCSPHNPTGRVWTGAELTRMAELAERYGVAVVSDEIHADFVHEGHVHVPWTRVAGAGGGRWALITSGSKAFNFPALTGSYGLIGDPADRAEFLRRMETAEGLASPAVLSLTAHIAAYREGAAWLDAVRAYVAGNLGHVAERLSAGLPELGWEPPQAGYLAWIDLRAAGVDDAELQRVLVERERVAIMGGAVYGAPGFVRLNVGCPRAKVERGVEALIRAVKAVRAVRSSPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPF4</accession>
    <name>A0A7K2ZPF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation inhibitor Maf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001551">
        <property type="protein sequence ID" value="MYW34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="14588" checksum="25D927F07E5D3C9A" modified="2021-04-07" version="1">AERPEAAGALVIGCDSVLELDGEALGKPADAEEATARWKAMRGRSGILQTGHSVIDTASGRHASATASTVVRFGEPSDAEVAAYVASGEPLHVAGAFTLDGRSAPFVDSIEGDHGNVIGLSLPLLRRLLAELEVSVTELWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPL3</accession>
    <name>A0A7K2ZPL3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ychF</name>
        <name evidence="7" type="ORF">GT040_34595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001586">
        <property type="protein sequence ID" value="MYW34267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561293.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001586.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="277"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="362" mass="39263" checksum="9A36A20EDED24ED9" modified="2021-04-07" version="1">MSLTIGIVGLPNVGKSTLFNALTKNDVLAANYPFATIEPNVGVVGVPDPRLNKLAEIFNSQKLLPATVDFVDIAGIVRGASEGEGLGNKFLANIRESDAICQVIRAFKDENVVHVDGKVSPKDDIETINTELILADLQSVEKAVPRLTKESRLQKDKIAVLAAVEDAQKILESGQTLFSAGITAATEKGKLLHELHLLTVKPFLYVFNVDEDELVDEDFKNEQRALVAPAEAIFLNAKIESELIELDDDEALELLQSMGQEEPGLATLGRVGFDTLGLQTYLTAGPKEARAWTIKKGATAPEAAGVIHTDFQKGFIKAEIISFDDLVETGSVAEARAKGKARMEGKEYVMQDGDVVEFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPP4</accession>
    <name>A0A7K2ZPP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_34825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001591">
        <property type="protein sequence ID" value="MYW34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="226"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="464" mass="49386" checksum="0C77EBC75667A1D7" modified="2021-04-07" version="1">MSRVSKPYEIVEQALELSTTDGLVVIADEHSSANLRWAGNALTTNGVTRGRTLTVIATVDGAQGTASGVVSRSAVTADDLEPLVRAAEAAARGAGPAEDAQPLVSGVPSSPDFTDAPAETGSEVFADFAPALGDAFARARSGGRELYGFANHELTSTYLGTSTGLRLRHDQPTGTLELNAKSPDRTRSAWAGRSTRDFKDVDPAAMDAELAQRLRWAERRIDLPAGRYETLLPPTAVADLLIYQLWSSTARDAVEGRTVFSRPGGGTRLGETLAPLPLTLRSDPHAPGLESAPFVIAHSSGDSASVFDNGLPLAPTDWVRDGKLERLTTTRHSAALTGLPVAPAIDNLVLDGGGERSLEEMVAATTGQALLLTCLWYIREVDPATLLLTGLTRDGVYLVEDGQVVGEVNNFRFNESPVDLLSRASEAGRTEKTLPREWGDWFTRAAMPALRIPDFNMSSVSQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPR7</accession>
    <name>A0A7K2ZPR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphopentomutase</fullName>
            <ecNumber evidence="7">5.4.2.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_35090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphopentomutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001601">
        <property type="protein sequence ID" value="MYW34364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="6">
        <location>
            <begin position="197"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="352" mass="36424" checksum="664D19485FCC1F74" modified="2021-04-07" version="1">DLDRRTRLPVAAGRAALGYPGADTFAGHQTMMGADFSRVSVARLADHLDEVAGALAAAGHRTERLDGRPLLLVDGTVLVHDNLEADPGINWNASGSLEDLPFEGDTGILAIARTVRAVAPVARVIAVGGHADGPLPGFVRPGEGGTVGLDTPATGFYRNGGLRVQHLGAPLDHTRQLPELAAGAGIPVTLVGKAADILVCEAAARRPAVATSEVLDHTLEAVRADGDALVVANVQETDLAGHQQDATRYAQLLEQVDAGLAGLVALLAASGDRLIVTGDHGNDPTIGHAHHTREYVPVLIHRPGEDGIELLPDADTLADVGATAARSLGLAPEQLATGTPLHTGRRTPVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPY9</accession>
    <name>A0A7K2ZPY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001619">
        <property type="protein sequence ID" value="MYW34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="103" mass="10117" checksum="900836536F5EE6FB" modified="2021-04-07" version="1" fragment="single">VPACFALLGLLRAGGALPSGFEPATPAWLFAGVLLTAGLTVGIARLTAFLGCEPIARARPAAALGASAAEPVKERPARRITGLVLLALGISAAGTATLQSGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ76</accession>
    <name>A0A7K2ZQ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Holliday junction branch migration protein RuvA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001634">
        <property type="protein sequence ID" value="MYW34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16193" checksum="0ACAE8554C42806C" modified="2021-04-07" version="1">REDSLTLYGFADDDERQVFELLQTASGVGPRLAQAMLATHSPDALRLAVSTGDEKALTAVSGIGKKGAQKLLLELKDRLGAPVGAHIGQQGVAAPHAAGWRDQLQAALIGLGYANREAEEAVSAVAPQAEAAVAEGTAPPVPQLLRAALQTLNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQD0</accession>
    <name>A0A7K2ZQD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">secF</name>
        <name evidence="11" type="ORF">GT040_35950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001634">
        <property type="protein sequence ID" value="MYW34527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="369" mass="39039" checksum="FE57B2C188B040E2" modified="2021-04-07" version="1">MSRLGNLGARLYRGEVGYDFIRNRKIWYGVSILITITAIVAVAVGGLNMGIEFKGGAVFTTDTKAKISTAEATEVATDASGHMAIVQELGNGGLRIQITEVGTAKANEIKETLSDELGIPAEEINADLVGPSWGEQIANKAWTGLAVFMVLVVVYLAIAFEWRMAVAALIALIHDITITVGVYALVGFEVTPGTVIGLLTILGYSLYDTVVVFDSLKEGQKDITKQTRFTYSEIANRSINSTLVRSINTTVVALLPVAGLLFIGGGVLGAGMLNDISLSLFVGLAAGAYSSIFIATPLVADLKEREPQMKALKKRVLVKRAAAAARGESPEDDGPAYGNDAVTEDAETAGAVVGQRQQPRGHGRTPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQW1</accession>
    <name>A0A7K2ZQW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001685">
        <property type="protein sequence ID" value="MYW34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029577084" evidence="1">
        <location>
            <begin position="25"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="29882" checksum="29E71055A2F0F69E" modified="2021-04-07" version="1">MNKPLIGAFFAALLLGAGITPAVAAESAQARESATETAPAAKAVTFAGTVALSNCSGSVVRSPDSQPTDPALVLSNGHCLETGFPGPGEVLVDRPSTRTFTLLDAAGSGVGTLKASKIAYGTMTDTDLSLYELTSTYEQIETSYGIEALELETAHPVAGTAITVASGYWKRTYSCDIDGFVHQLKEGRWTWKDSVRYTPECRTIGGTSGSPVIDDATGKVVAVNNTGNESGQECTDNNPCEVDENGEVTVREGINYAQQTYNMVPCIGTGNKIDLDREGCGLPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRD2</accession>
    <name>A0A7K2ZRD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001722">
        <property type="protein sequence ID" value="MYW34893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="319" mass="34586" checksum="A98F950263E712E1" modified="2021-04-07" version="1">MYGAEHLQAFGGLPAVDFQPKDDPADRPAADDVAWRISVEPYGDDDRDRPWADEFADFLGAVDPAGVKALIIGQWGEAYEENSSLPIDLVIAAADRLTSLEAVFVGDLEAEQAEITWIEHADVTTLLAAFPALTEFGVRGGSGLVFPPTKHDRLRSLTIQAGGLPVQVVRGVLDSELPALERLDLWLGVSAYEGDTEVTDLAPLLSGTRFPRLHHLGLRNSEVENEIAAALASAPVVARLRTLDLSNGTLGDEGAAALLEGQPLTHLDDLDLHHHFLTEAMEQRVRSALEPHGVRVDLSERNEPWDNRGAEGRYTAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRE9</accession>
    <name>A0A7K2ZRE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NCS2 family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_37955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001724">
        <property type="protein sequence ID" value="MYW34912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="50033" checksum="BDDC4443D092697A" modified="2021-04-07" version="1">MTQQSVEPKTSPESAGPGSRVPAGRSWLDRYFHISERGSTVAREVRGGVTTFMAMAYILLLNPLILGGEDVNGNLLSQPGLITATAFAAAATTLLMGFVGKVPLALAAGLSVSGVLASQVAPNMTWPQAMGMCVIYGVVICLLVVTGLREMIMNAIPLALKHGITMGIGLFIALIGLYKAGFVHQGTATPVSLGPAGELAGWPVLIFCVTLLLIFMLQARNIPGAILIGIIVGTLVAIVINAIIDIPAKAWSSGPPALEGSAVATPDFSLFGNVEFGGWGDVGVMTVGMIVFTLVLAGFFDAMATIIGVGTEAKLADDKGRMPGLSKALFIDGAGGVIGGVASGSGQTVFVESATGVGEGARTGLASAVTGLFFAACLFFTPLTAIVPTEVASAALVVIGAMMMQNARHVDWSDRSVAIPVFLTVVLMPFTYTITTGVAAGVIAYSAIKLAQGRAREVGAFMWGLTVIFIVFFALNPIESWLGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRN7</accession>
    <name>A0A7K2ZRN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001762">
        <property type="protein sequence ID" value="MYW35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="20862" checksum="F6618D6063FB9E2F" modified="2021-04-07" version="1">MNVLDHDLLTAARTGDTDGVRTAIEGGARVDVRDEELRTPLLLAALGDHVEAARLLVAAGADPDAQDRREDSPWLVTGVTGSVAMLRVLLPAGPDLTLRNRFGGVSLIPASERGHVAYVREVLRVTDIDVDHVNRLGWTALLEAVILGDGGRAHQEVVELLLAAGASPGLPDGDGVTALAHAERRGFEEIAALLRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRZ4</accession>
    <name>A0A7K2ZRZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001774">
        <property type="protein sequence ID" value="MYW35102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="16495" checksum="F7BD87516EEC37FA" modified="2021-04-07" version="1">GARLLLAGDGPEAGALKALADRLGAADRIRLLGECGADGSGPVPGIPALLSAVDTFVSTSREESFGLAAVEALAAGLPVLHDACPAIDDLSAAHAPGATRIAGSPDELTAVLRQRIQARPDRSPPPRAVGHYDIRRSSERLMDVYAYALDTAPPNRRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRZ9</accession>
    <name>A0A7K2ZRZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001776">
        <property type="protein sequence ID" value="MYW35125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7358" checksum="D0A8557EEFF2E4A0" modified="2021-04-07" version="1">MRTAVADGGRRVSVHLADQGRQALIVALSHQPAHEAANGTVLPELTRLGAVSCGTDTAEDGRRVWAVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS29</accession>
    <name>A0A7K2ZS29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_39380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001786">
        <property type="protein sequence ID" value="MYW35181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029692107" description="Beta-N-acetylhexosaminidase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="8">
        <location>
            <begin position="64"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="7">
        <location>
            <begin position="189"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW35181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="536" mass="58588" checksum="B487914821FCFC33" modified="2021-04-07" version="1">MSPTRGALVTGAAVTAAAAVVLTVVVWPEGSGSHPSRDAASPSGTSATAAAPSPSRSYPLSSTPSTIPAVREHTAGRGPGWQPGKDSSIVIAKGSQVLADEAQLLAKELKLPYRGAEAPREGDVELALGAKSQGPAESYTLTVRDRKVKITGPDESGVFYGTRTLKQSLKADKTFPEGVVNDRPDRPQRGLNLDIARKHYSAEWIEDRIREMGDLKLNQLGLHFSDDQAFRIESKTHPEVVSDEALTQDEVRRIVGLANSLHIEVVPEIDSPGHLGAVLRAHPDLQLRNTQGRESRGSIDISKPGAAKLIDELLDEYTDLFPGKYWHLGADEYQALMVSNPAASYPQLQRAAEQKHGSGATIEDLATGWLNDRVAVVEPKGRTAKAWNDGLFRDSKVKAAKNIEIEYWTGKEIGARPPQEYLAEGYKMLNLNDEFLYYVLGEPNEFVYPTGKRIYEQWTPMVLRGTEPVAQRYSPQILGGRFAVWGDLPDAQTTQQVADGIRMPLVATTQKLWDPRKPELTWAQFQELATRTGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS82</accession>
    <name>A0A7K2ZS82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPP34 family phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_39530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001792">
        <property type="protein sequence ID" value="MYW35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="24541" checksum="02E646AD93CF1CAE" modified="2021-04-07" version="1" fragment="single">MNASAPALTLPEELILLTLNPGSGKPLCPAASLAYGTAGAALAELELQGRIREERGRVQVVNPLDPADPLLAALLRTLPQAKGRRSGMRARHWVDNFDKHVRDTYLDSLVERSVLSRETRRFLGLFPSHRHFPVHPDLVPGVRRRFTLAETAGYPDHRDRLLAALVSAIGLAGELTRNGRPGRTAMKVLRRSEWTASAVHHNVKRNTSGGDSDGGDGGWGDGGGDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZT26</accession>
    <name>A0A7K2ZT26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001856">
        <property type="protein sequence ID" value="MYW35447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6753" checksum="A15633E99486530A" modified="2021-04-07" version="1">QEAAPLAPGRALERYRSLTEPERLVLSEGVWPPPHAVRVDTAQGAVWLHPDDAQHHPAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5X3</accession>
    <name>A0A7K2Z5X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_00245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000004">
        <property type="protein sequence ID" value="MYW27739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="549"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW27739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="716" mass="73834" checksum="98FE2103C40D10A3" modified="2021-04-07" version="1">MFTPARSARWLIPVVLLIAWLGIGGGLGPYAGKLGEVATNDQASFLPQNAESTQVIDAQKAFQQNETLPAILVWTSKDAGTPVSDAQREAATGALASLAGTEGVVGQASPALPSEDGLALQGIVQLSPDLGDELPTVLEEVKKAGAEVPDATVQLAGPAASQADLSDAFAGIDGLLLGVALITVLVILLLVYRSVLLPFLIILGSVFALGLACAIVYVLADHDIVRVDGQVQGILSILVIGAATDYALLLTARFREELAVQGDRFAAMRVALRESFGPITASAATVAVGLLALLLSDLTNNRALGPVGAIGIVCSVLSALTFLPAALVLLGRRAYWPAKPKPAEDGTGGHGIWSKVAALVDRAPRKVWAITLAVLIACAAFAPTLTSKGVPLDEIFVNDAPSVAAQETLGEHFPGGSGNPAVIIAAADKLSEVTEAATRTDGVASVAPVSEGGRPGGEPLVVDGKVRIDATLKAAADSDAAKETVAALREAVHAVPGSNALVGGYTAQQYDTQRTAEDDRMLIVPVVLAIILVILVFLLRSLLMPVLLVTTVALNFLATLGISSLVFTHVFGFSGTDSSVPLYGFVFLVALGVDYNIFLMSRVREESLRHGTREGILRGLTTTGGVITSAGVVLAATFAALGVIPLAFLVQIAFIVAFGVLLDTLVVRSLLVPALVRDIGPKAWWPGALSREGAEGQRGTTDADGQRGTTSAAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5X7</accession>
    <name>A0A7K2Z5X7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_00270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000006">
        <property type="protein sequence ID" value="MYW27744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="292" mass="31006" checksum="37CBB33182C4ACF5" modified="2021-04-07" version="1">MYRFLLTPRWWGINLFVVLAIPFCVFMGTWQLGRFEDRVQSHEQATQQPDPSTRAAKPLDELLPVDKVTSGRPAVATGTYADQFLVPGRELDERRGFYVLSLLRTEGGKALPVVRGWLPGTAGSVPVPAAPQGEVTVTGDLQASENIHSDGVDTRGGLPAGQLGMISAASLVNLVDYDVYDAWVTLPEAEAGGAGGALKPVPAAAPQGSGLDLKAFQNLGYTGEWFVFAGFVLFMWFRLVRREAEAVRDVALGLVPEGEEAREGEKADAGVAGAEGAIAVPAPETTKAAQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5X9</accession>
    <name>A0A7K2Z5X9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_00295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000007">
        <property type="protein sequence ID" value="MYW27749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="406"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="411" mass="44942" checksum="8F195FF6FC74D7BC" modified="2021-04-07" version="1" fragment="single">MTDLTAFPADFTWGVATAAYQIEGAVTEDGRSPSIWDTFSHTPGTIDGGDTGDVACDHYHRVPEDIGLIKQVGADAYRFSIAWPRVVPGGDGPVNKAGLDFYDRLVDGLLEAGVTPFATLYHWDLPQVLQDRGGWTVRETSEHFAAYASHVVDRIGDRVKDWATLNEPLCSAWIGHLEGRMAPGLTDLTAAVRASYHLHLGHGLAVQAIRAASSDARVGIVNNLSPIVPASTSEADLAAARRADGHINRWWLDPVLGRGYPQDMVETYGVELPVRPGDLETIAAPLDWMGLNYYFRQIVTADPSGPAPGFTQVPVADARHTYMDWEVYAHGLEQLLLRLTEEYGVERIYVTENGSAYQDTVAADGSVHDPERVAYLEEHLTACARAVAKGAPLAGYFAWSLLDNFEWAYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Y2</accession>
    <name>A0A7K2Z5Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000002">
        <property type="protein sequence ID" value="MYW27722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="198"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="37905" checksum="2AED056290BBEA28" modified="2021-04-07" version="1">MIVWINGAFGAGKTSVAGELIDLIPNSTLYDPELTGAGLRGLLPQKRLAEVGDFQDLRIWRRLVVDTAAALLAEMPGVLVVPMTLLRQEYRDEMFGGLASRRIPVRHVLLSPEETILRSRIAGRVEYPGDREQSERVNRWAYDHIGPYQDALGWITGDAHVIDNSALTPRETAERIAEAVRSGAAGACEIVQSPEPTAATVAAGVLLFDEQDRVLLVDPTYKPGWEFPGGVVEEGEAPAQAGIREVAEEIGFRLDRVPTLLLVDWEPPSPPGYGGLRFLFDGGLLRSEDAGRLLLPGSELRGWRFVTEQEAAGMLPPTRYERLRWALRARERSTVLNLEAGEPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Y4</accession>
    <name>A0A7K2Z5Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_00300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000007">
        <property type="protein sequence ID" value="MYW27750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="297" mass="32131" checksum="217BC71C59BD33D2" modified="2021-04-07" version="1">MSSLTRTSGPARSRTRSPMAAPQSFLWTRRIVLTLLAGFVLLPVYVMVSSSLKPLQDVSGKFQWIPSTLTIQPYFDIWETVPLAKYFVNSLIVAGSATVLSVTIAVFSAYAVSRYKFRGKRVFTVTVLSTQMFPGILFLLPLFLIFVNIGSSTGVALYGSRGGLILTYLTFSLPFSIWMLIGYFDSIPKDLDEAALVDGCGPVGALFRVVVPAAVPGIVAVSVYSFMTAWGEVLFASVMTNDATRTLSVGLQGYATQNDVYWNQVMAASLVVSVPIVAGFLLLQRYLVAGLTAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6J6</accession>
    <name>A0A7K2Z6J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mycodextranase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_01395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000060">
        <property type="protein sequence ID" value="MYW27960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14490">
        <property type="entry name" value="CBM6-CBM35-CBM36_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033801">
        <property type="entry name" value="CBM6-CBM35-CBM36-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029677329" evidence="2">
        <location>
            <begin position="46"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="644"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW27960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="788" mass="82554" checksum="BCD2796C87668576" modified="2021-04-07" version="1">MTPPPPPPRPGRILRRSLSASLALALTALAAATSLVVAGAPPAAAAAVPAPSPLNVPGRGATVPFKEHEAEYAATNGTLIGPNRLYGSLPSEASGRQAVTLDAVGEYVEFTLTAPANAMTFRYSLPDNAAGTGRDASIDVRVNGTQLKSVPVTSKYGWYYGGYPFNNNPGDTDPHHFYDETRTMFGSTLAAGTKVRLQVSSTAQSPTFTIDLADFEQVAAPIGKPSGALDVVSDFGADPSGAADSTAKIQAAVDAGRTQGREVYIPQGTFKVQDHIIVDKVTLRGAGPWYSVLTGRHPTERHKAVGVYGKYASQGGSSNVTLRDFAIIGDIRERIDDDQVNAIGGSLSDSVVDNLWLQHTKCGAWLTGPMNNFTMKNTRILDQTADGVNFHYGVTNSTVTNTFVRNSGDDGLAMWAENIPNVNNKFTFNTVILPILANNIVTYGGKDITISDNVMADTITNGGGLHIANRYPGVNSGRGTAVSGTHTAARNTLIRTGNNDYNWKFGVGAVWFSGLNEPIQGATINVTDTEILDSSYAAIHLIEGASNGLNFNRVKIDGAGTYALQIQSPGRASFTDVVATNIAQSNPIHNCVGAGFQITRGSGNSGWYADPPACTGVWPDPVWTNGGVPGGGGPGGPTDPPGPTDPPEETGNLAQGRAVTASSHVDVYGAGNAVDGNPNTYWESRNNAFPQSLTVDLGSAKAVKRVVLKLPPQAAWATRTQTLSVLGSTDNSTYNTLKASAGYTFNPSSGNTATVTLPGTSARYLRLAFTGNTGWPAAQLSEVEAYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6L2</accession>
    <name>A0A7K2Z6L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_01505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000064">
        <property type="protein sequence ID" value="MYW27981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="30423" checksum="E1B3A11652566349" modified="2021-04-07" version="1">MAETALAPLPGRTTRRIRVATSATIVVAVALAVLIVPPLAQLDQQAVDLSNKLHPPSWAHPFGTDDVGRDLLLRCVYGLRVSLLVGLVAALTATVIGTAIGALAGSFGGWPDRIVMRVVDTLSSIPHLLLGIFIVAMFRPGVWPVVISVALTHWISTARIVRSEVLSLRSRPFIDAAVSGGASRVRVIVRHLLPGVLPQAGLAAVLMVPHAMWHESALSFLGLGLPAHQASLGNLVQSARGSLLAGDWWPTLFPGLFLIIPTLALAGIAGAWRDRINPRRKSELML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6N8</accession>
    <name>A0A7K2Z6N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000063">
        <property type="protein sequence ID" value="MYW27973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="112" mass="11713" checksum="4ACD7B1227334261" modified="2021-04-07" version="1" fragment="single">MLTVAGVAPTGAYAAPVPPEIPGATATAQPGDALPPGWRIAGEKGRNHLEWRAPEPVPMGDARVEFRANGELLGVPEPQDDGRTFRLPLDEVPTADLGDLAVEAAGRRLDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6W4</accession>
    <name>A0A7K2Z6W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_02045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000098">
        <property type="protein sequence ID" value="MYW28084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="18228" checksum="0CF244D7D0DD8504" modified="2021-04-07" version="1">MTGAVRRVARVVLLDPDDRILLLHGHEPGDPGNDWWFTPGGGLEGDETHEEAARRELAEETGITDIELGPVLWKRICSFPFDGRRWDQDEWYFLARTAQTATDPQGLTELELRSVSGLRWWTSAELLAARETVYPTRLAELLRTLLDEGPPRVPLVLAAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7C6</accession>
    <name>A0A7K2Z7C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000129">
        <property type="protein sequence ID" value="MYW28256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="34" mass="3861" checksum="D2EA764311EDDF33" modified="2021-04-07" version="1" fragment="single">MKDYRSVADAVAAEIRAGRLRAGERLPTQREFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7G3</accession>
    <name>A0A7K2Z7G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000131">
        <property type="protein sequence ID" value="MYW28258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="25026" checksum="76F46156061D7FCD" modified="2021-04-07" version="1">LPALLGAEDDPDAFTPHHRLLAATRHRRPGLRLLRTGLVMESLIPSILEQKVTTDEAYRAWRLLVRRYGTPAPGPTATLGLHVIPDARTWAMIPSWEWHKAGVDAKRSSTIMRAVRVARRLEEASTMPLPEATARLELIPGIGPWTSAETLQRSNGAPDAVTVGDYHLPGIVGHALADNRHATDEEMLALLTPYEGQRHRATRLILLSGRIPERRGPRMTPGNIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7G7</accession>
    <name>A0A7K2Z7G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_03085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000144">
        <property type="protein sequence ID" value="MYW28284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="350"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="505"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="652"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="939" mass="100059" checksum="C85D5022B69F4F84" modified="2021-04-07" version="1">MSVLGAWLSPRSATGSSGLRARILLGTVCVGYSVGAAVGWGSPELARFMGDFGLAAAALVAAVSCFLYARVSAGRLRPAWLLFSLSSLMAACGNAVWGWYEVVLGVPVPTPSVADAFFLCFAPPAIVGLLVLAKRPVTRAGWVCLALDAWLIGGSLLTLAWSLALAHAAHMAGVQEASVGPAALSLAYPLLDIVLVSMVLALHFRRSGANRSAVNTAIAALALTVLCDAVFTSPLLRSTYNSGQLLDAGWFAGSLLLAYAPWGVRSRVPGTDRPGPPRAMSRPIAGSLAALTPYLAAAVCTLGILYNVVEGRRVDRVVIFTGCTVVLALVVRQGIMLLDNISLTQELAQKENHFRSLVQGSSDVIMIAAPSGTLRYVSPAAAGVYGRDAEDLVGAELSSIIHPDDLGRVVHEVRRFLAAPPHEEPTTRIECRFRSGTGDWLHAESTVNRHQGGLLLNSRDVTERVRLQAQLQHNAEHDPLTDLPNRALFTSRVRQALTGRRAGDSGTAVLFIDLDGFKAVNDTIGHQAGDELLIQAARRLQESVRAGDTAARLGGDEFAAIIMGDGTRDQGAREYQVHEIADRLRLTLSQPYRIGPSEVRVAASIGVAFAEPGITPTDLMRNADLAMYRAKAGGKDRVELYAPQMQADVVRRSELATRLRTALREGEFALLHQPVVHLASGSVAAVAAQARWRSAQGILFTPAEFLRVTGDDDRTAELGRWLLEEAVKQAADRARAGHPVTVSVRLSATRLLDKALPFGSIEALLTRHGLPSGALMIEVADSDPRVSFDELEQRLVALRRLGVRIALDGFGSGFAAINALRRLPIDVLKLDRNLVEGVVESARLHKITSGLLRIACDLGLQSVADGVDVPEQVLALRAMGCTHGQGMAFSGPLDEYRLRRALVRGQFPVPGVPGPRTVMAGGSIPLLTGSHAETPVPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7J0</accession>
    <name>A0A7K2Z7J0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005564">
        <property type="entry name" value="Major_capsid_GpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03864">
        <property type="entry name" value="Phage_cap_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="36654" checksum="23D88DD05EE5B664" modified="2021-04-07" version="1">MQLITEYASPAELTGYAREALRFREENTLNLNRWLPNETINDLTFRFNRGGGGLTEAANYRAFDAESDIATRSGGARVSGELPPISRKMPVGEYEQIRMRNVDTQNAEIRDAMESDSVKLVSQIAARIELARGQALFAGSVTLNENGVQASVDFGRSASHSVTAGTAWTSTETAAAYDDLQAWLEVYNDTNGGLPAYTLMSRKAYNLLRKNKQIRELAFAGSASAPGVLTREGLNAVLGQYDIPPIEIYDAKVSVNGTATRVTPEDKILFLPEQGDAAGKTLWGVPVEANDPRYGLAGDAAGIAVGGYKSEDPQTVWTRATAIALPIVANPDSTFVADVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7P2</accession>
    <name>A0A7K2Z7P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="20761" checksum="0E9FD10715E7762A" modified="2021-04-07" version="1">MGEQFRERVAALYADVDPLNLAMRVVNLEDELGADVDGICTGMHADVAEAQAEIERLAEIVRDYEHRINWFTTCAQCARLMDAVYDETIRADRYRLAWLSARRRAAEEANLGAEAVEHISRDRDLWRRYCDTARDTSAELSAEVAALRYQVEAVRAYALERCTEPYMNETSASWVLHLLGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7U0</accession>
    <name>A0A7K2Z7U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000156">
        <property type="protein sequence ID" value="MYW28406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="221" mass="23617" checksum="B4D8CD3316159CBD" modified="2021-04-07" version="1">MAVSLGEEIMLLSLDDTTGAAKGESAARWGVAAGMLLELVMAGRVTVKGGRVEVFDPTPTGDALLDGRLDRLARWVHGASSSRKVVEWLTREHAKGSQDVVDSLCARGLVTEERHRALGVFPVRRYPEADGSVERELRDRLAAVVLYGAEPDARTSALVALVHSTGMHPQAFPGLPKKQVAPRMAEIADGHWAGVSVREAIRNLQAAISTVTVVTVLSVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Y5</accession>
    <name>A0A7K2Z7Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000162">
        <property type="protein sequence ID" value="MYW28432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35010" checksum="E951D2160952B65E" modified="2021-04-07" version="1">GSGSVPAQPGPESVADASPLRVGHSDVMKLREAAQDARRWDSKYGGGDWRSSMVPECLRVDAAPLLLGSYTDEVGRALFGASAELTRLAGWMAFDTGQQEAAQRYYIQALRLARAAADVPLGGYVLASMSLQATYRGFADEGVDLAQAAVERNRGLATARTMSFFRLVEARAHAKAGDAAAAGAALKGAESWLERSRAGDADPSWLGFYSYDRFAADAAECYRDLKAPRQVRRFTEQALSRPTDEFVRSHGLRLVVSAVAELESGNLDAACAAGTRAVEVAGRISSARTTEYVRDLLHRLEPYGDEPRVAELRERARPLLVTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z809</accession>
    <name>A0A7K2Z809_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_03935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000168">
        <property type="protein sequence ID" value="MYW28445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="18679" checksum="7E07C7FF5CE32483" modified="2021-04-07" version="1" fragment="single">MTDDLRSAGAPTLEDVARAAGVSRATVSRVINGVRNVDPAIQEVVRQAVSVTGYAPNRAARSLVTRRADAVALVVSGAGVEPGPGPRGAGSRAAGDDGSFTAQVFADPFFGRVVTGVVNYLRPRGMHPVLMFAETSRARDDVVAYLRQGSADGALIVSTHAEDPLPGLLAEAGLAAVLYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8P4</accession>
    <name>A0A7K2Z8P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_05395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000247">
        <property type="protein sequence ID" value="MYW28717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="348" mass="35468" checksum="A27A0876574441DB" modified="2021-04-07" version="1">MKNTTPAALAPQVPAPLKNAPSRPEPRPERSTGSRIGELVQRQGVLAVLLTVILIASFLYPTFASVDNARGVTVQASFLAIVALGMTLVIITGGIDLSVGSVFALGGVLAAWASQWGFLAALLVPLVVCSAIGLVNGLLIARANMAPFIVTLASLLAARGILLAFTDEGATTYLVPKDSAFGELGQGSVWGFGYPILIALVLFGAGGLLLQRTSFGQTLFAVGGSSDAATLMGLPVARTKILVYTLSGLLAGLAGALNAARLSSGVTIVGVGMELDAISAVVIGGTLLIGGAGSISGTLWGVLLLAVIQNLINQIGSLNSSYQSVVSGGFLIVVVVAQRYLARSRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8S1</accession>
    <name>A0A7K2Z8S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000248">
        <property type="protein sequence ID" value="MYW28722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="17338" checksum="A5AA70109EF56B12" modified="2021-04-07" version="1">MNATPRILAVLDGILASAAPGERGALWHLAEQGRELDANLVRLPGGAEVGEHQEDVLDVLLVVLEGGGLVRTAGGELDLRPRTVLWLPRTSRRALVAGAGGLTYLTVHRRRPGLAIKAPSAANAYEGGEGPCMLDRVCPECGRLSEDPAPVFCSRCGERFPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8U8</accession>
    <name>A0A7K2Z8U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_05670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="20144" checksum="62A383740FCA56DC" modified="2021-04-07" version="1">MSERGALRTRLDLLSREVAKFGAVGAVGLLVNVLVFNLIRHTTDLQVVRASVLATFVAILCNYVGFRYWTYRDRDKTGRTRELTLFLLFSAAGAVIENGVLYLATYGFGWDSPVQSNVFKVLGIGIATLFRFWSYRTWVFKALPTARPLPDKEAARPAERFLEQRRPSETVEPDPVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8X5</accession>
    <name>A0A7K2Z8X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_05870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hyi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000256">
        <property type="protein sequence ID" value="MYW28810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="29545" checksum="A654BF164622E037" modified="2021-04-07" version="1">MGYPDQRFDVNLSILFTELPLLERPAAAAAAGFTAVELWWPWIETPTPIRAELDALKKALDDAGTQLVGLNFYAGQLPGPDRGALSVPGTESDRFRENIEVAADFAASVGCTALNALYGNRVEGADPQVQDALALENLVLAARAADRVGAILLVETLNKPESPLYPLVSAPAAIEVVDKVNAATGLGNAKFLLDLYHLSMNGEDLSQVIKAYAAKTGHVQIADNPGRGAPGTGTLPLERLLDELKDAGYAGWVGLEYKPGDRPSAEAFDWLPVSARAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Z6</accession>
    <name>A0A7K2Z9Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase small subunit</fullName>
            <ecNumber evidence="7">1.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD</name>
        <name evidence="7" type="ORF">GT040_07735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000358">
        <property type="protein sequence ID" value="MYW29170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="39"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="146"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="486" mass="52236" checksum="B4D1DB7FFCB6EDE0" modified="2021-04-07" version="1">MADPKGFLTTGREVAQTRPVAERVKDWNEVYVPGSLLPIISKQAGRCMDCGIPFCHNGCPLGNLIPEWNDYAYRGDWTAASERLHATNNFPEFTGRLCPAPCESACVLGINQPAVTIKNVEVSIIDKAWDSGDVTPQPPERLSGKTVAVIGSGPAGLAAAQQLTRAGHTVVVYERADRIGGLLRYGIPEFKMEKSHINRRIEQMRLEGTKFRTGVEIGQDIDAAKLRRRYDSVVIAAGATVSRDLPVPGRELGGIHFAMEYLPLANKVQEGDLTVAPIHAGGKHVVVIGGGDTGADCVGTAHRQGAASVTQLEIMPKPGEDRNAGQPWPTFPMLYKVTSAHEEGGERVYSVSTTHFEGDEDGNVAALHLVEVEFKDGKLEQKPGTERRIPAQLVTLAMGFTGTDQSNGLVQQFGLELDARGNVARDENYATNVDGVYVAGDAGRGQSLIVWAIAEGRSAARGVDRFLTGTSALPAPIRPTDRSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA24</accession>
    <name>A0A7K2ZA24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="24090" checksum="E1CA4C42E2355ACE" modified="2021-04-07" version="1">MSTVSTVSTSNKAGLDALLTPEESVLVLIDHQPFQFANLNSHEPTMVVNNVVGLAKAARAFDVPTILTTVLEERGGLLIQGIQDVFPEQKPIDRTFINTWQDQRVVDAVKATGRKKLILAGLWTEICLAMPAIQAAGEGFDVYAVTDASGGVSAEAHDMAVRRMVQAGVVPITWMAVLGEWQRDWAREETVPAAAEVQAQHGGASGVAFAWETQLLAAGRSRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA28</accession>
    <name>A0A7K2ZA28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arsenic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_08040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000369">
        <property type="protein sequence ID" value="MYW29231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="333" mass="34929" checksum="A22956494F0CE520" modified="2021-04-07" version="1">MTDTGTPRGAVERMEHHQVAVYLAAMALGALLGLAAPSPGPGLEHLINPVLGALLFVTFLQVPAAELLRSLRDGRFLSAALVVNFVVVPLVVAALFTFLPADRAVRLGVLLVLLCPCVDYVIVFSGLAGGSARRLLAVTPVLLVAQMVLLPVFLYAFLGSGLADIVEAGPFLEAFAFLIVIPLALAWGLQGWAGRRESGRKVSDAATTAMVPLMAATLLVVVASQVPKVGGNLTDVAAVVPFYTVFLVVMAFAGKAVARLFRLDVPAGRAVVFSGATRNSLVVLPLALALPDAYAIAAVVVVTQTLVEVVGMVLYVRAVPRLLPAQPQRHLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAT3</accession>
    <name>A0A7K2ZAT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000421">
        <property type="protein sequence ID" value="MYW29466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="204"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="447" mass="47950" checksum="9958145C073688C9" modified="2021-04-07" version="1">MADAPGPLGPVDEQALDEVVTFTSELIRIDTTNRGGGDCRERPAAEYTAERLADAGLEPVMLERTPSRTNVVARIPGTDRSADALLVHGHLDVVPAEPADWTVHPFSGEVRDGVVWGRGAVDMKNMDAMILAVVRGWAREGFRPPRDIVIAYTADEEDSAVDGSGFLADRHPELFEGCTEGISESGAFTFHAGQGLSLYPIAAGERGTGWLKLTAEGRAGHGSKVNRENAVTAVAAAVARIGEHEWPVRLTPTVRAAITEIAALHGISVDLDDPGFDIPQLLAKLGPAASLVQNTIRNSSNPTMLGAGYKVNVIPGQATAFIDGRFVPGGEDEFHETLDRLTGPLVSWEFYHREQSLQAPVDSPTYAKLRAAVETFDPGAHTVPYCMSGGTDAKQFAKLGITGYGFSPLKLPPGFDYQALFHGVDERVPVDALHFGVRVLDHYLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB10</accession>
    <name>A0A7K2ZB10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ORF">GT040_09690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="WWKE01000450">
        <property type="protein sequence ID" value="MYW29540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="108"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="318"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW29540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="473" mass="49252" checksum="EB1F8A6F3A1D88D2" modified="2021-04-07" version="1">MITLSLAEIAEIVGGQPHDIPDPAVTVTGPVVIDSREVAPGSLFVAFAGERVDGHDYAQRAVEAGAAAVLAARPVGVPAIVVDDVLGALGVLARTVVERLGTTVVALTGSAGKTSTKDLIAQLLQRHGPTVWTPGSLNNEIGLPLTALSATSETQHLVLEMGARGIGHIRYLTELTPPRIGLVLNVGSAHLGEFGSREAIAQAKGEMVEGLPEDGCAVLNADDPLVRAMASRTKARVLLFGEAPEADVRGEKVRMTPDGRPAFELHTPTGCSDVTLRLYGEHHVSNALAAAAVAHELGMSVTEIAEALSEAGTLSRWRMEVTERGDGVTVVNDAYNANPESMRAALRALAAMGQARAADGGRTWAVLGQMAELGDASLAEHDAVGRLAVRLNVSKLVAVGGREASWLQLGAYNEGSWGEESVHVSDAQAAVDLLRSELRPGDVVLVKASRSVGLEKVAQALLENSTEGEVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB41</accession>
    <name>A0A7K2ZB41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000430">
        <property type="protein sequence ID" value="MYW29495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="679" mass="71913" checksum="9FC1D3FFFBB93DDE" modified="2021-04-07" version="1" fragment="single">RGHYLGADAARKVTGRVRNHPVALYRVERTLMVRGAGQPASAARPVRVVSLDWYSTQDARRLAGWDSRTPGATGPNPDAEPPVPWYLNREDPVHLGGQVRAEGFVPDRRPAPVPATTTTPAPATNTTTPAPATTSTTTPAPAPAPPQDPLKAFGDTVLDTLHRAYPSLFVPPLMLRHPHLAKLWYGDGRMRTALHNERQVREALNRPTLAQSLDDLTTTGVPVTLTEDGKVRRGHHTLILRARLTDRRFETTMSERSLRNAVVGTEISGQGQQESTTLSAGVELGISPRDHDKDPGTGLPRQAGNVSLGARQALSWTRATKNTVAVTHDQLAFQNGADLYSYQVELGATFEGHRRPRGWTRLVSAGLLGAGVFVSKVAERPLFSGGTETVGRVELAVPAAHGSERHAPADPPPTGPAPTPAPTPAPRPLTSTEADQLLDGTRPLPRTTAADRQLVNKLLSAPHVVLSAEGGEQRQRLVQDTADRATGSSWHVSAPGTPIRTALRRAMANLGVAGQLGQYLGPFGSRITGLTGAGPFSTHYLKAAVRGELDNLRVRSDPKPGSLEATIGNEHRVAGSSGSGSRTTLGLQGGVTPVQQAPGQQALVGAYTSALQYAWGKGRSVSQTLTRGRNTTLSYAGRMYLVVADAAETVAVRDRWTAAMGAVGTRAGGGISSAAGRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBH2</accession>
    <name>A0A7K2ZBH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="227"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="338" mass="38063" checksum="63B230AB293F684A" modified="2021-04-07" version="1">MTTAWLVLAVGDEDRQHGGNDGYDDDPSQHYSWDDTVHHHARIAVGDVIALWDKKQLLGLGVISEIETGSEIKTLYFCPECKKADFKRRKRLKPTWRCNKCPAMFEEPGSKQRRVVTYRSRHGETWMDGRGLLTGRQLRALCDSPDSQLSMRPARWERLRDALLALDGIDFSDLDLDDDKSQDSGGSTADSKQRRKIAGGHRISKVRTRVGQKPFRQQLLNDYGQVCAFTGPAPAGALQAAHLYSYADEEEHHEWGGLLLRNDVHSLFDRGQIGVNPGTGCIEVDDELLGYPAYAELHGRAPQVSLRPEHQVWLAAHWRQHWTARVTVPASRAPQPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBI4</accession>
    <name>A0A7K2ZBI4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ORF">GT040_10680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01000490">
        <property type="protein sequence ID" value="MYW29731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="24"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW29731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="420" mass="45999" checksum="6A77FF20068531A0" modified="2021-04-07" version="1">MSTFQAPKGTYDLTPPDSAKFLAVREAISAPLRDSGYGYIETPGFEDVELFARGVGESTDIVTKEMYTLTTKGGSQLALRPEGTASVLRAALQANLHKAGNLPVKLWYSGSYYRYERPQKGRYRHFSQVGAEAIGTEDPVLDAELIILADQAYRSLGLRQFRILLNSLGDKECRPVYREALQTFLRDLDLDEETRRRIEINPLRVLDDKRPDVQKQLTDAPKLRDYLCDACKAYHEEVRALLTAAGVVYEDDEKLVRGLDYYTRTTFEFVHDGLGSQSAVGGGGRYDGLSEMIGGPALPSVGWALGVDRTVLALEAEGVELDLPVTTSVYAVPLGEEARRALFTVVTELRRAGIAADFAFGGRGLKGAMKSANRSGARYTLVAGERDLAEGAVQLKDMESGEQSAVPLAEVVAELTMRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCA2</accession>
    <name>A0A7K2ZCA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000527">
        <property type="protein sequence ID" value="MYW29895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="159"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="30869" checksum="997F5D6A67104B2F" modified="2021-04-07" version="1" fragment="single">LRAGEPVGPRRPSPPPAPDGDAFDLLAQEMGRAQDAAVTAVVQASQLFSSTGNEQKVEVFVNLARRLQSLVHREIQILDELEHEVEDPDLLKGLFHVDHLATRIRRHAENLAVLGGAVSRRQWSNPVTMTEVLRSAIAEVEQYPRVKLVPPMDGTLRGHAVADVIHLLAELVENATVFSAPHTQVLLRVQRVTAGLALEVEDRGLGMPDHEQNRMNALLSDPDQVNVAHLLQDGRIGLFVVSALARRHGIAVRLQSNIYGGTQAVLVLPQTLLGADPDAATAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCK9</accession>
    <name>A0A7K2ZCK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000596">
        <property type="protein sequence ID" value="MYW30097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22494" checksum="9A42EC2B8277A186" modified="2021-04-07" version="1" fragment="single">MVQTHRDTRGRVAELLALREQARRGPSERATQAQHAKGKLTARERIELLLDAGSFKEVEQLRRHRATGFGLEAKKPYTDGVITGWGTVEGRTVFVYAHDFRIFGGALGEAHATKIHKIMDMAISAGAPLVSLNDGAGARIQEGVSALAGYGGIFQRNTRASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRETSQMFITGPDVVKAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCT0</accession>
    <name>A0A7K2ZCT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000585">
        <property type="protein sequence ID" value="MYW30075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="101" mass="10852" checksum="3F8B197C21F3A925" modified="2021-04-07" version="1">GAMVGAGWPPAQATRIGALMRYFITGSALGSFAGGFVDDESAYDPADYPHLGQAHLLAERGRQVDEGAFETGLRALLDGLALQYEEYARPTETVRRAPNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD12</accession>
    <name>A0A7K2ZD12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000609">
        <property type="protein sequence ID" value="MYW30212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029449420" evidence="1">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="10287" checksum="9248DA593983F22A" modified="2021-04-07" version="1">MPNPRRMSRRAWVLTWALLCVAGLAATAWLQAAASAPEARPEYIKAECREYIAEIEGRIHVAKSNSKGEGAIVAFSRDRTDCAEELDDLLGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD96</accession>
    <name>A0A7K2ZD96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000645">
        <property type="protein sequence ID" value="MYW30289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7304" checksum="B80C374933E0DBF9" modified="2021-04-07" version="1" fragment="single">PLPQMPPAPALPPEAVADELLQAFGPQGILRFDQRAVSRQGVPEIVARTLVWAGLPADFGPFFWAQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDE5</accession>
    <name>A0A7K2ZDE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000655">
        <property type="protein sequence ID" value="MYW30339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="59"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="600" mass="66049" checksum="4DF31EEF05127BC9" modified="2021-04-07" version="1">MPDPEELEALRERYRHERERRVRPDGVRQYRSTDAEFGYYAADPYTEPAEREPVHDTVDVAVVGGGFGGILAGARLRQRGVERIRIVEQGGDFGGTWYWNRYPGIHCDIESHVYLPMLDETGHVPGWKYSPGEEIRRHAVRIAQKFALGPDALFSTTVTSLAWDEAAEAWLVTTDRGDAFRATYVVTATGTLSEPKLPGIPGIEDFTGHTFHTSRWDYAYTGGTPEGGMTGLAGKRVGVVGTGATGIQVIPMLAEDAGHVHVFQRTPSTVDVRANRRTTAQDVGADHEGWARERRENYLRIVSGEPEERDLVADGWTRSAVLLEKLLPSFRRGGDRNAFEAAYEVADAAKMNELRARVERSVTDPGTAERLKPWYRYACKRPAFSDAYYQAFNRSDVTLVDTADTHGIERVTAHGVVVGGTTYELDCLIFATGFSVGTSGILSGKLPVHGLGGRQLLHRWGQEGPRTLHGFTSNGFPNLVQMGTLQNASSVNFTHILDEQAVHAAALIAAAEAGGAVIEPSREDEDAWIAALAEDAPDHEWFHAECTPGYYNREGRGRPNGPFTYPHGAVAFHELLGRWREESMAAILRPRATGGLQPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE29</accession>
    <name>A0A7K2ZE29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_15170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000717">
        <property type="protein sequence ID" value="MYW30582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029504043" evidence="5">
        <location>
            <begin position="37"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="6">
        <location>
            <begin position="490"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="632" mass="66986" checksum="A80E6CF3EDBA08B0" modified="2021-04-07" version="1">MPHPRPLRLRARAAGAALVVAVAGLGLNATVTTAQAADPVAQVWVTTTDGSRKLTADGNVPFTGTPQGVDIRIDANSKGQKFTGAGASVTGASAHLIQTLPQDRRTSLLRSLFSAEGDGIGLNYLRQPLGSTDFDANSNAYTYEDTRGSFSIDRDRGQIIPVLKQATAINPAIRFMGSPWSPPAWMKTNNSLNGGSLRTEHYQAYADYLVKAIRAYGQEGITLTDLTAQNEPEFATSYPSMSMTATQQADFFQVLDRTLTAADLPTNLLAYDHNWDHPNYPLDVFARTGGIQRIIGAAFHCYGGAPAAQQQIVNAGKRVFFTECSGTDSANPATTFGDTLKWHTENLVVQNMRNGGETVINWNLALDQNGGPHQGHCTNRCNGIVEIAGGQVTRNAEFYVLGHVTKFIKPGATRIGSTSQGAGGVQNVAFQNPDGTRAAVVVNTASASQRFSLTDNGKSLAYTLPAGAVATFTWDGNGGTTEPPAGSIDPAAWYRVQNTNSGACLDAADWGTGDGTALQQWACGTGANQGWQFRPAGGGHYQVVNRHNAKVWDVDGGAGATADGTKVHLWSYAGSTNQQWRPEPLAANGRYRFVARHSGKCLTVDNSSTANGARLTQQPCNGSAAQSFALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE83</accession>
    <name>A0A7K2ZE83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000728">
        <property type="protein sequence ID" value="MYW30660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="40"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="296" mass="31215" checksum="96DAA219CD66C9FD" modified="2021-04-07" version="1">MPPGSAPVDSVPLDSATLVRTLIAAQFPHWADLPVEAVDASGTANAVHRLGDDKVVRLPRTESSAADVATEHFWLPRLAAQLPVPVPAPLAQGAPAEGFPWAWSVCTWLEGANPLPGDGTWAPELFAADLAEFVLALRRIDPTDGPQAYRGEPLASRDEKTRKVIAGLDGVLDAGAATAAWDKVLTAPAFTGAPVWVHGDLQPGNVLVADGRLTGVIDFACMGLADPAVDLIAAWYLLPAGAREAFRTAVGADDASWERGRGWALSIAVMELAAYRESNPVMARNAWWVIGELLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEF1</accession>
    <name>A0A7K2ZEF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029613986" evidence="1">
        <location>
            <begin position="27"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="432" mass="47342" checksum="CAE2BB8E34998580" modified="2021-04-07" version="1">MRRTLVRRAAAAAAVLALLLTGCSGTDDGRDADGTIRLRFQSPAWQKESVDANKQLVKEWNAAHPDVQVDYVQGSWDNVHDQLLTSFEGGEAPDIIHDASDDLADFAYGGYLADLRPLLPERLKADIPERSWRTTTFDDGIYGVPFLQEPRVLIANTKILKASGVRIPTPERPWSWAEFRQVAKELTGKGRYGVAWPLKEPVSVTLNLGLSGGGQLFHRDPDGKAELRFEEGDRVVTGTIHDQVNTDRSAARTALGMGGSDALPGFFGGRYAMLPLGFAYRQQVLEQAPEGFAWTVLPAPAGRGGLAQGVSPQTLSVAEDSLHKEEAVAFIDFLLRPPNMVRLARGDWMLPTGTTALAHPSLHTTENGWATGTALAKHLRPAPAQTVRGYPEWKDKVATPALQEYYSGAIGMDELRKRLVDDGNRVLARYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEK4</accession>
    <name>A0A7K2ZEK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000737">
        <property type="protein sequence ID" value="MYW30715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029653746" evidence="2">
        <location>
            <begin position="31"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="40"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="426" mass="44743" checksum="2C17F64F68E94B10" modified="2021-04-07" version="1">MITRNRLTTGVCIALATLAAGLGSVLPAAADEPPATPAPKVELVLDVSGSMRTRDIDGQSRMNAAKQAFNDVLDAVPEEVHLGIRTLGADYPGDDRKVGCKDTKQLYPVGPLDRTEAKTAVATLAPTGWTPIGPALLGAADDLEGGEATRRIVLITDGEDTCGPLDPCEVAREIAARGTHLVIDTLGLVPNAKIRQQLTCIAEATGGTYTAVQHKDELSRRVKQLVDRAAEPAVTPVATEGAADCSAAPALKPGLYTDRQVIGEHRWYRVDVLPGQELRVSASVAADRAVDNDYGVLLRAVTGTGREIVRGSESGTGRTDVISSGLRYPKAGIEDGDNGSGKPAAEIVCLQLSNAFSAPASVKRTPGLPVELTVDLVDGPDQASDVAAFGLGRGWWLLGALVLTGLIAGLLFGWISRWRIAVWRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEL5</accession>
    <name>A0A7K2ZEL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000759">
        <property type="protein sequence ID" value="MYW30776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="586" mass="63642" checksum="165F30A5A338FC2C" modified="2021-04-07" version="1">MSSVPSLLSRPYAQFRRGARPGHDRWNTWDPPKAEVLGVARTLTSATRLVDVMHLLRTEDGIEKFFTVNPGSAFADGLDSYLTGLGVQVLSWKEATRRSFDLAVSCSVHPTMRRLDAPLMVLPHGAGYNRLVTESTGDALSPAGLSRRELMWRGKVVPQAIGVSHQAQIDRLTETCPEAVPYALAVGDWCFQRIIASMPHRDRYRSRLGAVDGRRLVVVHSTWSRHSLLGRHPELPLRLVTSLPADEFAVAAVFHPNVWARHSRPGVLERLGAAMDAGLMIIPPQEGWRAAVVAGDWVVGDHGSTTFYSAAADRVTLLAATGLDELDPASPAAAFGQEAPRLDPDGDVYAQLLAAARGHDPAGLRPVVDRQLASVDTSGEVTRARMYAFLAGRGVEVPDAAPRPLPVPAPEPVRHTSPTAYDVTGAHDLGGTVDLRRRPLVAGHHTEALGFYAVTTEENHPHWPHAAEVLARTAADAEVAALDWAADAAVRYENLNVLVARLDGGRCLVRLRGGRQLEARTERSWGERRPLLDPVLLGSAVNLWMTDAERVKDLTDGLTLRTGRWEVRVAFTEPSDGPGSGLRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEM4</accession>
    <name>A0A7K2ZEM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000762">
        <property type="protein sequence ID" value="MYW30801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045732">
        <property type="entry name" value="DUF6086"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19564">
        <property type="entry name" value="DUF6086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15901" checksum="B97E7527243409E7" modified="2021-04-07" version="1">MSQYFDIGDETLWNPSNGASRMFQRQVVVFEAELELPSGIGPMENDECQISPDTFEVFVNALLAKHRRTSHAIWLALAEGFTATALVLAERAGIKVDWALLGATPEAEMADAQVSTVTGLSAPAEAGAWAAGLRRKARELGRRMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEY0</accession>
    <name>A0A7K2ZEY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000792">
        <property type="protein sequence ID" value="MYW30914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="11409" checksum="E0CA7441D6B94931" modified="2021-04-07" version="1" fragment="single">MTDDRTHVLDFFTPRAAGWDSRFPDDGPAYAAAAGLLGLRPGDAVLDAGCGTGRALPALRAVVGPRGTVLGADLTPAMLEAAVRAGRAESGTLIRADVARLPLRDEALDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF92</accession>
    <name>A0A7K2ZF92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_17525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000819">
        <property type="protein sequence ID" value="MYW31031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="284" mass="30366" checksum="C268CE445C4EB464" modified="2021-04-07" version="1">MTATSDTTGKTAGPLVELDDVSKFYGNIKALEHVSLEVHAGEITCVLGDNGAGKSTLIKIIAGLHRHDAGRFLIEGEETTLANPRDALDRGIATVYQDLAVVPLMPVWRNFFLGSEPTTGVGPFKRLDVKKMRETTRTELLRMGIDLRDVDQPIGTLSGGERQCVAIARAVYFGAKVLVLDEPTAALGVKQSGVVLKYVAAARDAGLGVVLITHNPHHAHLVGDRFILLKRGAMSGSHTKDDVTLDELTRQMAGGSELEELSHELERTPAPTLPGTSAATEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFN3</accession>
    <name>A0A7K2ZFN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000855">
        <property type="protein sequence ID" value="MYW31109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="18625" checksum="BFC67420301A00F7" modified="2021-04-07" version="1">MDDLVTARLVLHPMTVSEAQRVVAGEVDSGARWAPGYPTAGDVSAAWRFLGTHADTGDPQPFGNYEIRRREDGTAIGGVGFHGAADENGSVTVGYGLIPSMRGKGYASEALRGLLLFARTRGVTCVKGDADHDNIASQHVMMAVGMRPTGQDERVRYFEIAWTDATANSGPRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFZ5</accession>
    <name>A0A7K2ZFZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000866">
        <property type="protein sequence ID" value="MYW31215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="511" mass="54141" checksum="0C97C6CFDA12A1AD" modified="2021-04-07" version="1">TGDGQSVRTAAAVERERESYDVTLKGISRTGKVPASGDVMLEDLGNAGFVSFGSVFKNGVAKVRVPKGTYVLNSNVVTDPKKKWDVDWLVQPKLSVTKNTTITLDARKTKPASITLPVKGTTLRGIQTEYTVASKQTELGYGWAVGGKGTLRTAHVGPKITDGSLSQRWAGSWNKGAAGDYNIAFGGKVTQFATGVSRKYKASQFATVKLTMGVGAVKKKTGEVAPIAELPGGYGMYGAPAYQALPGARTVRVATSDKARWGLMFAQIGGKDKKGRLIYESGYILGDPAAYKGGKSYTKTVNTGVFGPRLTGYDGVYRDGNEIAGFVPLLADGKGNDGASAFSSVTTVLHRNGKKYAQTEDPLQGWDYFTVPAGSADYKLSSSVRHTAKIGALSTRVDVSFTFRSKKSAAKLPASTVRFTPALSTDGRAKAGKTVSVPVKVQGSAAGKNLKSLATYVSYNGGKTWKKVTVKKGKITVKNPAKNKAISFAANITDKKGNKSTVRIYNAYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG80</accession>
    <name>A0A7K2ZG80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="31172" checksum="17E57A16352EE89E" modified="2021-04-07" version="1">MSPQSEPREQSAVTVIGLGPMGRALAGAFLDAGLRTTVWNRTPGRDRELVERGAVSAPSAEEAVAASALTVVCVVNYDAVDAVLRRDAVAGALKGRTVVNLTADTPGRARSTAAWAAEHGVRYLDGAIMTPTVTIGTPGAVLIYSGPEDLYREHRSVLHVLGGTHTHLGEKICRAAAYDIALLDIFWTAMAGFNHALAVARAEGITARELAPFAAGIGAILPAIFTEVAEEVDQETFSAEGTPLTSTASTMAHVIHTSEAHGIGAGVMRAAEGLARQAIGLGHGEEGFHRVAELLGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGA9</accession>
    <name>A0A7K2ZGA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000910">
        <property type="protein sequence ID" value="MYW31394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="39"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="27280" checksum="DF7392642A2B57F2" modified="2021-04-07" version="1">MGADSGRFRGTESRISQWLRRRPKSPGAEAEETARMALLLAVADAGMPIAPAAHPLGYRCSCERIGCPTPARHPVSFAWQTQSTTDQAQIERWADSQPLANFITATGMIHDVLDVPLTAGRSALERLLAAGIDVGPVAQSGEDRMLFFTATRGTPEDEDEWWPCELDCHPETMDAHPGLRWHCRGSYVLLPPARLPGELDVHWVRGPEHELPDPLTLLETLTDACARYAGSAEQSELDHDSIAWPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGG3</accession>
    <name>A0A7K2ZGG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000910">
        <property type="protein sequence ID" value="MYW31395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="127" mass="13708" checksum="FC323EBBCD1B4206" modified="2021-04-07" version="1">GAAEYGIPDTGDLAADLKLVLRATVDELNDPLMEAPTRALTAEGIVDAKLGAEFVEKLLDPQLALYVTRLRAAQEAGQLRPDADPRVALELLIAPLTHRWLLRTLPLTHAYADTIVDYALGGLVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGH3</accession>
    <name>A0A7K2ZGH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000912">
        <property type="protein sequence ID" value="MYW31405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13516" checksum="1A11CECE2173CED2" modified="2021-04-07" version="1">MSTSDRAASIGRRTHGATRLVLELIQKEWLLPPWKWEEIAEQLDELSAALAAGDLAAVDVLTGELEAASGPRVSRIGAPPDGEPSEGDRRVPLPEEYRERVVALVHTLTTESAPGGSRPEPSERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGP7</accession>
    <name>A0A7K2ZGP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000942">
        <property type="protein sequence ID" value="MYW31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16718" checksum="399D37925195FFA3" modified="2021-04-07" version="1" fragment="single">MTEQSEWRFSDDRGQLSTAPRRPERVLAYVQAGATLWGLGIRPQAIFGSDHDGPDPDRAKTGTLPLDEVAYVGAGSGLDVGRLLSGRPDLVVAVSYGNGHVYGLAPETAKPLEERVPVAVIDVSQARTFEEIGDRFAELARSLGAEDRADADADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGV1</accession>
    <name>A0A7K2ZGV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">folE</name>
        <name evidence="7" type="ORF">GT040_20460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000967">
        <property type="protein sequence ID" value="MYW31584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="201" mass="22144" checksum="946FCD59A1D87F76" modified="2021-04-07" version="1">MTDPVTLDGQGSIGDFDEKRAEAAVRELLIAVGEDPNREGLRETPGRVARAYKEIFAGLYQQPEDVLTTTFDLGHDEMVLVKDIEVFSTCEHHLVPFRGVAHVGYIPASTGKITGLSKLARLVDVYARRPQVQERLTTQIAESLMAILEPRGVIVVVECEHMCMSMRGIRKPGAKTLTSAVRGQLRDPATRAEAMSLIMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGW8</accession>
    <name>A0A7K2ZGW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpt</name>
        <name evidence="4" type="ORF">GT040_20470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="WWKE01000967">
        <property type="protein sequence ID" value="MYW31586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003968263.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6209102"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="19252" checksum="3FD6209C2CB022C2" modified="2021-04-07" version="1">MGTDLQSVLLTKEEIDAKLVELAAKIDAEYAGKDLLIVGVLKGAVMVMADLARALSTPVTMDWMAVSSYGAGTQSSGVVRILKDLDTDIKGKHVLIVEDIIDSGLTLSWLLSNLGSREPASLEVCTLLRKPDAAKVAIDVKWIGFDIPNEFVVGYGLDYAEKYRNLPFVGTLAPHVYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGX5</accession>
    <name>A0A7K2ZGX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000969">
        <property type="protein sequence ID" value="MYW31596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="294"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="842" mass="90996" checksum="777E2C038DEA070C" modified="2021-04-07" version="1">AELRLPPVAATFSSWIAATHQRVASPEVQGQIPYWTEVASKIRSPFPRTALTESGTVDREFGVSAEVTGRLARIGASVPGAELQHALLATLTRAYREAFAVPEFPVLLEGHGRSDSPGSPDISGTVGWFTSMYPAVLRGAGDGGTPVADVQAVREQLRAIPGGGDDYGVLAYLDHSVPPLVSAVPVAFNYLGAMPSGMELASFAYGDFRSGASRRECAVEFNLFKYGDDLRVSMRVDRAFADSPEVLKLLEAYERNLLALAEGLDGTHAPAVKEPAALPAADREAVLAAYGDDVQHILPLTPTQEGLLYHELMHPGGSDYFGQVVTTLHGSLDLPAFEAAWNIVIAENEMLRTVYGWENLSRPVQIVLGSAGFRIDHRDLTDRADETERRRAVDDLLAADIAAGFDLTAGPLLRVTVVRTGGDEHVFAFSFPHISLDGWSVFRILARTLELYDAGVPEPASIEAAPSFRSYAEWLGNLDLTEARAYWSRYLTDSTPWVLPPEARSSADEDRFSQLDLVLDEEETTLVREFAAGAHCTLSTVLQTALALTLRIVSGADDVIFGVTVSGRSPDVPDVERVVGLLINTLPMRVRMADDEPVDSLMGRIQTDGFGAIEHSGLATTHILESAGPEKGSGAGAGRSRAQFDVLFILENYPLGPEFLTSKNLGIGSFASHERTNYPLTVVAIPGERLTVRFSSMTGVVEPAWVSAFMGLFRTALHQVSSGHRLVTDVDGVDAAALADLLRSSQNAPTVEAEHEDQQRFFADFRGPVFVLDEQARPCPVGVPGHIHVAADSVSDLPVDGEWGQWMAEGETEPGFPSPHRYLYPTGDVGMWTGRDSIKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGZ7</accession>
    <name>A0A7K2ZGZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000975">
        <property type="protein sequence ID" value="MYW31633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="147"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="24369" checksum="202212EA358C4035" modified="2021-04-07" version="1" fragment="single">MMDHAHDLGAVREATDRLLSEAGKWDNAALAEPSRLPGWSRGHVLTHLSRNADALGNVLRGLPMYASSEMRDADIEAGASRPLDEQLADFRESADRLRAVADEPADWSRTVTLRNGVTDSASRVPFRRLIELEIHHVDLDAGYELEDLPADFTEREIVFLTDRFSGHPDVPATTVTAEDGRIWTTGGGSDGPAVSVRGAAADLLGWLAGRRDGSALTVGGGALPALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH57</accession>
    <name>A0A7K2ZH57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000970">
        <property type="protein sequence ID" value="MYW31599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="599" mass="64880" checksum="F1CC5B642DD4278C" modified="2021-04-07" version="1">MAAPPQVGGLADAVFDYAEDDPQRVALGRKDAGGQWRDVTSGAFRDEVLALAKGLIAHGIRFGDRVALMSRTRYEWTLFDFAIWSVGAQSVPVYPTSSAEQVHWMLHDAEVVAVMVEHEDHAMTVGSVIDRLPHLKRLWQLDAGAVDELVGAGGMVDDEVVHRHRRAVTPESAATVIYTSGTTGRPKGCVITHASFMFESDTMVARWEPVFHSKPGDEAATLLFLPLAHVFGRMVEIAAVRGRVKLGHQPELSANALMPDLVTFRPTFILAVPYIFEKVFNGARRKAEAEGRAGPFDKAVDIAVKYAEALEQKAFGLGPGPSAGLRVQHQFFDKVVYKKVRDAMGGRVRHAMSGGSGMDRRLGLFFAGAGVSVFEGYGLTESTAAATANPPERTRYGTVGLPIPGTSVHIADDGEVWVHGPNVFSGYLNNPAATRAALEDGWLATGDLGSLDEDGYLTITGRKKEILVTSGGKSVSPAGLEERVRAHPLVAQCIVVGNDRPYIAALVTVDQESVDHWLTMQGRTPLAPAELVRDPDLEMEVRRAVVAANTAVSQAESIRTFRILAHPFTEEHGLLTPSLKLKRKAIETAYGVEVDALYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHF8</accession>
    <name>A0A7K2ZHF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000986">
        <property type="protein sequence ID" value="MYW31689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032722">
        <property type="entry name" value="Deaminase_XOO_2897"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14440">
        <property type="entry name" value="XOO_2897-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="418" mass="44684" checksum="81850CA2327A0DBA" modified="2021-04-07" version="1">AAEEAAKDAQKFAESAQEAAKQAENAGNTGQIETGTVPDAAGGPIGGVFYVVNEIDKVGEPQVVKKTEGCDGWWDQLFYDGDCTMTQKISYKADLDLYLCSTEVWENTCSSADTMFLGETKTDVLSTEVTHTITIAEYQQGVDPVDILFGSWIRCAQKLTPGGENGSWGGCAWAVVDVAAMFAGKVLRPIADAFRAADAAARTGIGFVDALKALRALPLADDVVARLGYRVMDEFVEACTRKSKRVAALAATTADGCGGLIRYNSDDLSRMAYQFRVESGFFGAKHNVAVARVPGWNDPKTGDLVVASSGFSGHSETAILDMLKAKKVDPSRITSLYTERQPCASCASELSGALKAGTPITWSVPYFDGIESAAKQLLAKYVMQAGGGRVARSSEDLQKQERETHEPARIRSTAKSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIA6</accession>
    <name>A0A7K2ZIA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001076">
        <property type="protein sequence ID" value="MYW32068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="13974" checksum="88967FF82E914129" modified="2021-04-07" version="1">MSVELNHTIIHSRDNRESAEFFADLLGLEVGEEWGPFIAVVLANGVTLDFATIPEESITPQHYAFLISEAEFDAAFGRIKELGIAYYADPHLKFPGEINHNDGGRGVYFPDPSGHHMELITRPYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIF2</accession>
    <name>A0A7K2ZIF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan DD-metalloendopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001085">
        <property type="protein sequence ID" value="MYW32095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="241"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="347" mass="35475" checksum="4065A7459278CFC9" modified="2021-04-07" version="1">MASNQPAPEAPSPFTADGLGGPERTWEEWNPTAESIRPVRGKHRVAKQRGLARSSTVLGVGVIAAVGAGGMATAQSKPPVSISLPDSIADNLPDAKSLPGVGAFMAEEAEAAPVTAAPLTTAGITTAEADQGATDAGEALRARILQQAEQQQASADAEAKAAEEKAAAEKAAAEAKKQQDEAEAAVKAKIAAEKKAAEEAAAKKAEEERLAKLRASYTLPTSSYTLTSTYGQSGAMWSSGQHTGLDFAGAAGSPLKAVHSGTITSAGWSGSYGYRTVLQLEDGTEIWYAHQSSIDVSVGQQVSTGETIGRMGATGNVTGVHLHLEVRTAGGSAMDPAAWLNSKGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIN0</accession>
    <name>A0A7K2ZIN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WhiB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="186" mass="20443" checksum="C60A02BFC22F967F" modified="2021-04-07" version="1">MSGNRTGVANAPAIVLADDRIPFPDTDQVLRCRTSPALFQIEDIPNTDQDPRAREKALAKAKHACSGCPIVKDCLKWALANPALTKTGVWAATTKRDRTQLRKQLVARLGEDWVGVVAEQDRLRRERARAARAVPPTARELALARLELESIPTRPAPYNRWKEPITPQRAASNLRVLALVASGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ22</accession>
    <name>A0A7K2ZJ22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_24565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001152">
        <property type="protein sequence ID" value="MYW32353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01272">
        <property type="entry name" value="ACUCPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="5">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="390" mass="41692" checksum="4EB3787DE6A3ED49" modified="2021-04-07" version="1">MSGRAQLMWDDAVTGYDFGESHPMDPVRLALTMGLVRAFGLDEAVDLRQAKPVGDSTLRLVHRQDYVSAVRAASANPRAADQEYGLGTVDDPAFAGMHEASALIAGLSVGAAEAVWRGETAHAVNFTGGLHHAMPGAAAGFCIYNDPALAIARLLELGAERVAYVDVDVHHGDGVQAAFWEDPRVLTISLHEHPRTLFPQTGWPEETGAGDGEGSAVNLALPAGTGDAGWLRAFHAVVPELLADFRPQVLVTQHGADTHFEDPLAHLAVSLDAQRAVMESCHELAHQYAEGGRWVALGGGGYAVVDVVPRSWTHLVGIAAHAPVDPESVVPPSWRDLVYARTRQLGPGRMTDGRTPSWQSWEDGYDPADRLDQAVIATRKAAFPLRGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ64</accession>
    <name>A0A7K2ZJ64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001155">
        <property type="protein sequence ID" value="MYW32381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="40" mass="4009" checksum="0B5C2441E346BA27" modified="2021-04-07" version="1">EAARRATALALRWEAEADAEGGGAEKGARPEASGEQAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJP5</accession>
    <name>A0A7K2ZJP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001198">
        <property type="protein sequence ID" value="MYW32553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="348" mass="38061" checksum="015AE5B325540D20" modified="2021-04-07" version="1">METTGRSGGKRVVVTGATGNVGTSVVRALARDPEVGSVLGLARRRPSLDIPGVEWDTVDLSRDDSEERLTGLLRGAYAVVHLAWRFQPTHDPVTTWRSNVLGSQRVFRAVARSGTPALVHASSVGAYSPGPKDEPGVDEEWPTHGWPDAAYCREKAYLERVLDTFELRHPQIRVVRMRPGFLFKETAAPEQRRIFAGRHVPGNLLRPDLLPFVPDLEGLRFQVLHTDDAAEAYRLAVLKDVTGPFNLAADPVIDARALAELLDARVVRIPRALVRTALAGAWRAHAVPASPHLFDAVLRLPVLDSSRAHAVLGWQPTRSAQEALTAFLRGVREGRGEETAPLAGRKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK17</accession>
    <name>A0A7K2ZK17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-amino-4-deoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_26305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001224">
        <property type="protein sequence ID" value="MYW32690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01559">
        <property type="entry name" value="ADCL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017824">
        <property type="entry name" value="Aminodeoxychorismate_lyase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="273" mass="29080" checksum="C2CF5F13A05FEC32" modified="2021-04-07" version="1">MRIWVNGGLRDADAARLSVLDHGLTVGDGIFETVRTGEGRPFALTRHLDRLTRSARGLGLPDPDLDEVRRAATAVIDANPVTLGRLRITYTGGLSPLGSDRGTAGPSLVVALDGVSRRPDTTAVITVPWTRNERGALTGLKTTSYAENVVALARARERGASEALFPNTVGRLCEGTGSNVFVVLDGRIHTPPLASGCLAGITRALAVEWTGAEESDLAMEVLAEADEIFLTSTLRDIQAVHRVDDRELAPEPGPVTAKAMRIFDERAGNDLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK44</accession>
    <name>A0A7K2ZK44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 1 glycosylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001238">
        <property type="protein sequence ID" value="MYW32713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="52" mass="6070" checksum="4CE02BA559F4EB33" modified="2021-04-07" version="1">LLDNFEWAYGYDKRFGLVHVDYATQRRTVKSSGRRYAELIREHAGRRAGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK58</accession>
    <name>A0A7K2ZK58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_26505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001247">
        <property type="protein sequence ID" value="MYW32725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="23454" checksum="85DD4DC0CA010DCA" modified="2021-04-07" version="1">MYELLKGLGAWLTGSEQWAGSDGIGHRLAEHLQYSLLATLIAAAIALPVGLLIGHTGRGAFIAINLSSFGRALPTVGLVVLVFLASGLSMWPVYIALVALAVPSIVTNTYAGMTAVDPEVRDAARGQGMRRHQVLLQVELPLALPLIMTGLRLALIQVVATATIAAYVSFGGLGRYVFDGLAQRDLVQVLGGAVLVAVVAVVLDLALSALQRVLFRHRPSTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKA0</accession>
    <name>A0A7K2ZKA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001221">
        <property type="protein sequence ID" value="MYW32679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="29386" checksum="57422F41BB71D9FF" modified="2021-04-07" version="1">MSIVVTGATGELGRLVIDELLATVPAGEIVAVVRNKEKAAALAARGVELRIADYDLPETLAEAFRAGDRVLLISGSEVGKRVAQHSAIVEAAKAAGVAQLAYTGILGGPDADFLLADEHKATEQLILDSGLPYTFLRNGWYTENYTANLAPVLEHGAVVANAGEGRIASASRADYAAAAAAAVTGEGHLGKAYELSGDTAWSLAEYAALLSEVTGEEIAYKEVPAAVHQEILVGAGLPEGFAAILTDVDEAIARGRLAGTSGDLARLTGRPTTPLATTVRAALATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKY9</accession>
    <name>A0A7K2ZKY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001304">
        <property type="protein sequence ID" value="MYW33017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="51" mass="5331" checksum="D915D91C44413143" modified="2021-04-07" version="1">MQTRPTSSSTCSGVPAKSAGKRPEDGTAVSRFMASGPNSFTHQVIHLSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL51</accession>
    <name>A0A7K2ZL51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="9218" checksum="0D9147EBD6FEECD4" modified="2021-04-07" version="1">MVGIGLAGMPMPEWKIRTCHGKEYVFDSLEEAVEALPDYGEGATVWRRDVYRATPFITGTRRPWRQVEVPGPTQPGVAQDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLA2</accession>
    <name>A0A7K2ZLA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001328">
        <property type="protein sequence ID" value="MYW33123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="76" mass="7969" checksum="CE29309F65E78F44" modified="2021-04-07" version="1">VVATTARHAPLHANIDLALAVLSVACGMAAEAGETVFAVSRTAGWIAHALEEYGERPLRIRPSGQYAGPRPPQPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLH2</accession>
    <name>A0A7K2ZLH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CYTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001348">
        <property type="protein sequence ID" value="MYW33168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="23019" checksum="167CBE6D029C17A1" modified="2021-04-07" version="1">MKHEYEAKFLAVDVADLQNRLSALGAVQAFPRTLLTRKIFENDSLDDGAWIRLRDEGTRSTLTLKQVTDATTIDGTKEIETEVTDLHAMADILRRAGLTEVRYQENYREEWRLGEVAFDFDTWPGLPTFLEIEGPDEASVRQAAALLDLDYSEARFGSVDEIYKSESNRDILAEPTLLLSEAEKQKDASPSSQNRTAFTAGQRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLM5</accession>
    <name>A0A7K2ZLM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001344">
        <property type="protein sequence ID" value="MYW33149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="44" mass="5093" checksum="F624236C3DFA32EB" modified="2021-04-07" version="1">VRARGAEDRVMLFVPAHPARRWCSAARRGNRARVARHCQRHRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLV8</accession>
    <name>A0A7K2ZLV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">secE</name>
        <name evidence="9" type="ORF">GT040_29790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="10477" checksum="06C72D4C4047CF15" modified="2021-04-07" version="1">MTDAVGSIDMPDAEDESPESSKKTRKGGKRGKKGPLGRLALFYRQIVAELRKVVWPTRSQLTTYTSVVIVFVVVMIGLVTVLDTGFARVIKYVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM41</accession>
    <name>A0A7K2ZM41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_30205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001393">
        <property type="protein sequence ID" value="MYW33425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="33082" checksum="4968486201C7A3F7" modified="2021-04-07" version="1" fragment="single">MSEAEQAREPQGDKNGRLLAGRYRLGGVLGRGGMGTVWRADDETLGRTVAVKELRFPGAIDEDEKRRLITRTLREAKAIARIRNNGAVTVYDVVDEDDRPWIVMELIEGKSLAEAIREDGTLTPKRAAEVGLAILDVLRSAHREGILHRDVKPSNVLIAEDGRVVLTDFGIAQVEGDPSVTSTGMLVGAPSYISPERARGHKPGPPADLWSLGGLLYASVEGCPPYDKGSAIATLTAVMTEPLDPPKNAGPLTEVIYGLLARDPDQRLDDRRARALLNKVINAPEVPPADSTQVMALPVVPADAEPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM74</accession>
    <name>A0A7K2ZM74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_30315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001395">
        <property type="protein sequence ID" value="MYW33447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="6">
        <location>
            <begin position="36"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="13416" checksum="E021F2FD5C4BC953" modified="2021-04-07" version="1" fragment="single">MAGIDQEKALDTALAQIERKFGKGAVMRLGERPNEPIEVIPTGSTALDVALGVGGLPRGRVVEVYGPESSGKTTLTLHAVANAQKLGGSVAFIDAEHALDPEYAKKLGVDIDNLILSQPDNGEQALEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMH3</accession>
    <name>A0A7K2ZMH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmH</name>
        <name evidence="6" type="ORF">GT040_30950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001435">
        <property type="protein sequence ID" value="MYW33564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003967884.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001435.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZMH3"/>
    <dbReference type="GeneID" id="31221116"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="45" mass="5226" checksum="690F9E38FC029CEF" modified="2021-04-07" version="1">MSKRTFQPNNRRRAKTHGFRLRMRTRAGRAILANRRGKGRSSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMY4</accession>
    <name>A0A7K2ZMY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001446">
        <property type="protein sequence ID" value="MYW33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="317" mass="34612" checksum="3EFCD55A93E8CC0C" modified="2021-04-07" version="1">MRRSVERAAGKVMSMREAVAAFVHDGGTVSLEGFTHLVPTAAGHEIIRQGRRDLTVVRMTADIVVDQMLAAGCVTRLVSSFVGNSSAGSLGELRRRIEHADPEPLAYEEYSHYGMVCRYLAGAQRLPFYPLRSYAGSDLPSVNPGIRKVTSPYPAADGSAEQIYVVPPVNPDVTFIHAQRADRRGNTQIWGLTGIQAEAVYAAKKAVVVVEELVADEVVRADPNRTLVPAHAVDAVVVCPRGAHPSFAQGYYDRDNAFYRAWSAISKDPVRLREWLAEWVYGTADHAAYVAKLGEEFWAGLAVGEALSGQVDYGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN37</accession>
    <name>A0A7K2ZN37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001458">
        <property type="protein sequence ID" value="MYW33771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="461" mass="49864" checksum="85EC083468BDAFDC" modified="2021-04-07" version="1">GALAEVLRGVRPVFGDSAAARAALPELLGPGRPVPTGHRAILAPLRGRRRVIGAAVFVRSTERAPFEASDLLVAAQLATHTALGIDKAVLYGREAYIADELQRTMLPDSLPQPTGVRLASRYLPAAETARVGGDWYDAIPLPGSRVALVVGDVMGHSMTSAAIMGQLRTTAQTLAQLDLPPQEVLHHLDEQAQRLGSDRMATCLYAVYDPVAHRITIANAGHPPPVLLHLGGRAEVLRVPPGAPIGVGGVDFEAVELDAPAGATLLLYTDGLVESRLRDVWTGIEQLRERLAATAQLTGDDHSPPLEALCDDVLDMLGPGDRDDDIALLAARFDGIAPSDVAYWYLEPEDAAPGRARRLARRALARWGLEEMSDEVELLVSEVVTNAVRYAERPVTLRLLRTDILRCEVGDDSPQLPRQRRARETDEGGRGLFLVNRLARRWGATRLSTGKVVWFEMATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN70</accession>
    <name>A0A7K2ZN70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001445">
        <property type="protein sequence ID" value="MYW33709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="35070" checksum="24C1421C1EB4C9A9" modified="2021-04-07" version="1" fragment="single">MPRFTVIVPAFRVQAYLHACLDSVLSQSFKDFEIVVVDDCSPDACGPIADEYARRDPRVTAIHLPRNAGLGPARNAGMERATGDYLIFLDGDDTLLPESLQAIADRIGATGDPDVLMYDYARTYWSGRSVRNVLADRLDERGPASFRLADRPELLHLLMVVWNKAYRRSFVEAEGFSFPPGYYEDTPWTYPVLMSAGSIAVLDAVCVSYRQRRRGNILSTTSEKHFDIFDQYDRVFAFLDAHPELDVWRPVLFRRMLDHFCAVHASPDRLPRPSRAAFFRRATASCRRYRTPGAPVPRRARLRHGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN75</accession>
    <name>A0A7K2ZN75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001482">
        <property type="protein sequence ID" value="MYW33805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="26757" checksum="AF047DAB6B53BBB0" modified="2021-04-07" version="1" fragment="single">MPSPTLTPSPAVGVLLPRDLPTDLILPFARRAEELGFGSVWVVEDLGFRGGITQAAAVLASTSRIRVGIGLLPAGARNVAFAAMEIASLAQLFPGRTDIGVGHGMPGWMRSVGQWPTSPLTFLHEYIDALRALLRGEAPEVRGRYVHLAGVRLERGALPDVVPDILAGVRGPKSLAVSGQVADGTILAEPVAPEYVRAALGQIAPTRPHRLVAYNIGSVGADPAAALAAARPGLEWIGEPEWHAHIAPLPFAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP62</accession>
    <name>A0A7K2ZP62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_33860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001547">
        <property type="protein sequence ID" value="MYW34127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="28277" checksum="757FD038B74CE342" modified="2021-04-07" version="1">MSGVSVTKAAENAAPAGDDLVVLSDVNKHFGALHVLQDIDLTIARGEVVVVIGPSGSGKSTLCRTINRLETIDSGAISIDGKPLPQEGKELARLRADVGMVFQSFNLFAHKTVLENVMLGQTKVRKADKKAAEEKARTLLDRVGVGVQADKYPAQLSGGQQQRVAIARALAMDPKVMLFDEPTSALDPEMINEVLEVMQQLARDGMTMIVVTHEMGFARSAANRVVFMADGKIVEEATPEQFFSNPRSDRAKDFLSKILHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPD7</accession>
    <name>A0A7K2ZPD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001582">
        <property type="protein sequence ID" value="MYW34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="25585" checksum="9AE5ED4C5492E609" modified="2021-04-07" version="1">GDVSDHEQARELVELAVSAYGKLDILVNNAGILRDRMIFSMSEDEWDAVIRVHLKGHFNTTHFAAAHWRSRSKEAGGPVYGRIVNTSSEAYLAGSAGQPNYAAAKGGIVGLTTSTALALAKYGVTANAICPRARTRMTEDVFAGFQEPADGTLDALAPEHVSPLVGYLASPAAAGVNGQLLVVHGGMVAIVERPRVAAKFDAAKETFTFAELDELITPYYADRPPNETFAAAEVLGLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPN1</accession>
    <name>A0A7K2ZPN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="4" type="ORF">GT040_34735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001589">
        <property type="protein sequence ID" value="MYW34295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="34852" checksum="95BB454CAFE398EC" modified="2021-04-07" version="1">MNLASIPSPSTGVIELGPIPLRGYAFCIIIGVFVAVWIGNKRWVARGGKAGTVADIAVWAVPFGLVGGRLYHVITDYQLYFSDGQNWVDAFKIWEGGLGIWGAIALGAVGAWIGCRRRGIPLPAWADALAPGIAIAQAIGRWGNWFNQELYGKPTDLPWALEISEGPNRVAGTYHPTFLYESLWCIGVALLVIWADRRFKLGHGRAFALYVAAYCAGRGWIEYMRVDEAHHVLGLRLNVWTAIIVFALAVAYIVISAKLRPGREEIVEPEKDAAEAVKDAEKKDDADAADATEKDGDPLKKDTPAKDTPAKDAAPEAADKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPR0</accession>
    <name>A0A7K2ZPR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_35075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001601">
        <property type="protein sequence ID" value="MYW34361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="347" mass="36561" checksum="A64D440DC7FB18BD" modified="2021-04-07" version="1">MGAVTLKDVAERAGVSIKTVSNVVRNAPRVSDATRVRVMEAVGELGYRPNASARRLRTGRSGLIALAVPDLTTPYFAELAHHVAREASGRGFTVLIEETRGDAREELRLATGVGASLLDGVILSPLRVSPADLAPVADEFPLVLLGERSYGGEHVVADHVLIDNVAAAREVTAHLASLGRTRIGAIGVDEQGSATSRQRLTGFQQALYEAGLRYDPRLAAQVGEFDRPNGLAAMRTLLGLPDGVRPDAVFCFSDMLAVGAQRALYEAGLDIPGDVAVAGVDGSAEGLYSTPSLTSVVPDQASIAAMAVSCLVTRIGSEDPIPYEVRTAPHRLAVRESTDGVRRPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPV7</accession>
    <name>A0A7K2ZPV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">moaA</name>
        <name evidence="14" type="ORF">GT040_34850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="WWKE01001591">
        <property type="protein sequence ID" value="MYW34318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW34318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="36094" checksum="E4DF08EB2488455C" modified="2021-04-07" version="1">MLIDTFDRVATDLRVSLTDKCNLRCTYCMPEEGLQWLGKSELLSDGEIVRLIRIAVTDLGITEVRFTGGEPLLRPGLVSIVEQCAALTPRPRMSLTTNGIGLKRTAAALKAAGLDRVNVSLDTLRPDVFKTLTRRDRHKDVLEGLEAAREAGLTPVKVNSVLMPGLNDDEAPELLAWAVANDYELRFIEQMPLDAQHGWKRDGMITAGDILASLRTRFTLTAEDDEARGSAPAERWTVDGGPHRVGVIASVTRPFCRACDRTRLTADGQIRTCLFAREETDLRSALRSDAPDAEIAQLWKVAMWGKKAGSGLDDPSFLQPDRPMSAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ90</accession>
    <name>A0A7K2ZQ90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001636">
        <property type="protein sequence ID" value="MYW34534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="232" mass="24826" checksum="DD8F61ED8403EA3E" modified="2021-04-07" version="1">MCQDTEDGRTDENLRTSLSGLPSEVVAGSGFHAFKLNVENKGDKAYKRVDLGLVAAQVDDDNWLPNTDHLTLQFKDPETGAWSDISLDQDDEVIGYIGYTDIRARESFSIDLRLSVDKKAPEGYGFAIVIGLYADEEGNCVYPEGEQFYEFDVLAAGTDAGEPNEAEPQTGGKKPVPAKPVGNTEIKPEGTLARTGSDSNLPVIATIGTVAILVGAGVVFALGRRRKGDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQB7</accession>
    <name>A0A7K2ZQB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase SLT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_35980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001635">
        <property type="protein sequence ID" value="MYW34532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029762064" evidence="2">
        <location>
            <begin position="44"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="165"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="25492" checksum="1E8DB24D0520A5AE" modified="2021-04-07" version="1">MSATRIPDRLRRLNKVQKISVAGVSALAVASLTFSLVPSNAEAEVSPQAAAAAAPVAFTGGSAQAKTVQDSLIAQHSTAEQLVKAADAAKAKAAAETKAKAAKDKAEKAAKAKADAKKRGAEAANRSTARKPVYANNLDGWIREAMSIMKKEGIPGSYNGIHRNIIRESSGNRWAINNWDINARNGIPSKGLLQVIQPTFDRYHVKGTKKDLYDPVANIVAACNYAADRYGSMDNVNSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQD5</accession>
    <name>A0A7K2ZQD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001638">
        <property type="protein sequence ID" value="MYW34552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="92"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19965" checksum="4D93A413A547EAF0" modified="2021-04-07" version="1">MSLPHAILTALLEKPSSGLELTRRFDRSIGYFWSSTHQQIYRELGKLEQAGRIRALPTVAPARGQKKQYEVLPAGREELAAWVALPEDPRPVRDPLLLRMRAAAVVGVNGMEAELRRHLALHERQLAEYREIEERDFTPAPEGDADRLRHLVLRGGIDLETFWIGWLTRAIGDLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQS3</accession>
    <name>A0A7K2ZQS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001678">
        <property type="protein sequence ID" value="MYW34685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="12212" checksum="7906867D8618A316" modified="2021-04-07" version="1">MSDWTPEAGTPPVSTPEEPDLPQDGPVADAPSFEPAEPAPLGVERTPTGRAEVDALLERLADADHLPADGHTEVYEDVHRGLKSALTSLDARPAAAPGPPRPGPTPAYDNTHDHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQV9</accession>
    <name>A0A7K2ZQV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001685">
        <property type="protein sequence ID" value="MYW34761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="7128" checksum="07D370E0AE95EF74" modified="2021-04-07" version="1" fragment="single">MYEPIRTPSVHSPADEADFPHRSREEELDIQLAGHLAALLAVTDELGLGPAGDRIAEQVARLRGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQZ1</accession>
    <name>A0A7K2ZQZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_36685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001676">
        <property type="protein sequence ID" value="MYW34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35437" checksum="3052A697803918E0" modified="2021-04-07" version="1">MTTPTTPVNRLRPRRSCLAVPGSNPRFLEKAQGLPADQVFLDLEDACAPLAKEGARHHIVDVLNNGDWSGKTRVVRVNDWTTHWTYRDVITVVEGAGPNLDCIMLPKVQDAQQVVALDLLLTQIEKTMGFEVGRIGIEAQIENAKGLVNIDDIAAASPRLETLIFGPADFMASINMKTLVVGQQPPGYPADAYHYILMRILMAARTHDLQAIDGPFLQIRDVDAYREVAGRAAALGFDGKWVLHPGQVDAANEVFSPSQEDYDHAELILDAYDWCTSEEGGKKGSAMLGDEMIDEASRKMALVIAGKGRAAGMQRTSKFEAPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRK2</accession>
    <name>A0A7K2ZRK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">tatA</name>
        <name evidence="8" type="ORF">GT040_38470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001744">
        <property type="protein sequence ID" value="MYW35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512828.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001744.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW35011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="54" mass="5999" checksum="8218BA59F57D4614" modified="2021-04-07" version="1">MLRNGLEPWHLLILAVVVIVLFGSKKLPDTARALGKSVRILKSEAKAMKDDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRT1</accession>
    <name>A0A7K2ZRT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper chaperone PCu(A)C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001770">
        <property type="protein sequence ID" value="MYW35065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029771068" evidence="1">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="16069" checksum="340A3B1AABFA74F1" modified="2021-04-07" version="1">MNRRTVLAGALALTTGLALAGCSTGSDEPELKVVGAYLPQPVSDMAAGFLVVQNSGDAADRLTSVTSPLSDDVTIHETKNQQMREVESFEVPAGGELDLERGGNHIMFMDLKRQPKQGEKVSVELHFEKAGRITVDLPVKETTHNPKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRU7</accession>
    <name>A0A7K2ZRU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1775 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_38750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001770">
        <property type="protein sequence ID" value="MYW35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029649198" evidence="3">
        <location>
            <begin position="30"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="30"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="26133" checksum="9EA2C673F48E6FB1" modified="2021-04-07" version="1">MSATNVSRIAIAAGVAASTVLLLAGPAAAHVSVQPQGEAAKGGYATLNFKVPNERDQASTVKVEVNFPADHPLSSVTPEAVPGWKIDITKGKLDKPLEVHGRKITEAVTKVTWTADGSKIAPGYFQQFPVSVGQLPEDADQLVFKAIQTYDNKEVVRWIEEPKGGEEPDSPAPVLKLTAATEDHHGGAAGDDDKGDHKADDQAASAEGDKKETHAASSSSDTTARTLGIIGILVGIAGVAFGVLAGRRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS34</accession>
    <name>A0A7K2ZS34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteinase inhibitor I78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001789">
        <property type="protein sequence ID" value="MYW35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7696" checksum="0AE5152AC1F82AAA" modified="2021-04-07" version="1">MASEPTPSVQPDDAPDSYVGLGADTAEQQARSRGWDTVRAVPPGTILTMEFRSGRINFQVEDATVTRCWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS61</accession>
    <name>A0A7K2ZS61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001799">
        <property type="protein sequence ID" value="MYW35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7484" checksum="CFD76A8FE195BB33" modified="2021-04-07" version="1" fragment="single">MSNSSSEHERTYHHGDLRRAILSAALDAIAAEGPAALSLRDLARRAGVSHAAPAHHFKDRTGLLTAVATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS98</accession>
    <name>A0A7K2ZS98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2867 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001782">
        <property type="protein sequence ID" value="MYW35168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="524" mass="57607" checksum="70FCABC0BF3C1A69" modified="2021-04-07" version="1">MTDLPEEPDVHEAPDETPLRCLVTGATGYIGGRLVPALLDAGHQVRALARTPQKLRDYPWADRVEVVRGDVTDADSLTGAMRDVDVAYYLVHALGSGSDFEETDRQAARNFGEKARAAGVRRIVYLGGLTPAGVDEKELSPHLRSRAEVGRILLDSQVPTAVLRAAIVIGSGSASFEMLRYLTERLPVMVTPSWVSTRIQPIAVRDVIRYLVGSATLPPEVNRTFDIGGPDITTYREMMQGYARVAGLPRRVIVPVPVLTPTLSSHWIGLVTPVPRSIARPLAESLRHEVVCREHDIVRYVPDPPEGPIGFDRALSLALQRIKEARVDTRWSSASPPGAPSDPLPTDPDWAGGSLYRDERELAVPVDRADLWRVIEGIGGENGWYSFPLAWAVRGWIDRIVGGVGLRRGRRDAHRLRVGDSLDFWRVEEIVPGELLRLRAEMRLPGLAWLELSVATDDQGRTLYHQRALYHPQGLLGHAYWWGVSPFHAVVFGGMARNIAAAAQAAARARQQGREPVAGSGTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSH7</accession>
    <name>A0A7K2ZSH7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_40015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001831">
        <property type="protein sequence ID" value="MYW35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="76"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="473" mass="48057" checksum="15955FF28D1A68CB" modified="2021-04-07" version="1">MPDSGGSRAQREHIPTSGTGPGSDSAPPTPHGDAGALSVDPGAPQVTAPAGLPAAPEAGGLTAPAVKAARRTGFLVTMVLGGLTALPPLSMDMYLPALPAVTDSLAAPAATIQLTLTACLAGMALGQLVVGPMSDRWGRRRPLLLGMVVYVIATAICALAPSAELLIGFRLLQGLAGAAGIVIARAVVRDLYDGVEMARFFSTLMLISGVAPIIAPLIGGQVMRFTDWRGIFAVLTGVGVVLTLVVWKWLHETLPPGSRHTGGVGEALRTMRGLLADRVFAGYMITGGLAFAVLFAYISASPFVVQEIYGASPQTFSLLFGLNSIGLIAVGQINGKLLVGRISLDKVLGFGLAVIVLAAVALLLMTTGVFGEVGLVPIAAGLFVLMSAMGVAMPNTNAQALMRTKHAAGSASALLGTSSFLIGAIASPLVGIAGEDTAVPMAVVQVVCAVAAVGCFLGLCRPWQRAGREAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSI7</accession>
    <name>A0A7K2ZSI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001830">
        <property type="protein sequence ID" value="MYW35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="133" mass="13809" checksum="915BF181C36B8D7E" modified="2021-04-07" version="1" fragment="single">MTEPTAQGARDPRAGEPRTADVGRLLRCAAVFLPGPVPREGRIAFWDPHAEPGAPARDGSSSFAYADSAYATGAYADDRAPADAVPYSASPLTVVRRDGATGLRTAEVPAALLPVADALPVLVRARHQASAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSW2</accession>
    <name>A0A7K2ZSW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lamin tail domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_40035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001831">
        <property type="protein sequence ID" value="MYW35299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029615516" evidence="2">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="16941" checksum="4B43AA947D1F7ED7" modified="2021-04-07" version="1">MRIRTAAPIALAAATALAGSLLATAAPATAAAHQGGLHFGTIQYDGPGKDDRSKKSLNAEWVNIHNNGKKKVQLKGYEVKDNTGYTYTFGSYTIGAGKTVKVRTGKGKNVAGTVHWNRGSYVWNNTGDKARLIKPNGKLQDSCSWGKSTPKNKGVKNCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSZ3</accession>
    <name>A0A7K2ZSZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_40845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001860">
        <property type="protein sequence ID" value="MYW35452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="518" mass="53526" checksum="EA74F0C9501B75A0" modified="2021-04-07" version="1" fragment="single">MSGTTTAGVRLRRVADGANRWVVLVVLCLSLLVVALDATVLHVAVPSVTEDLRPSATGLLWIVDAYPLVCASLLILFGTLGDRIGRRRVLLLGYALFGVASLLAATADTPAVLIAARALLGVGGAMIMPATLSILRQVFPDRRERALAIGVWTAVAAVGAATGPVVGGFLVEHFWWGSVFLINIPLMAVILPLGRWLLPESRGADDGPWDVLGALTAAAGVLGVVLGVKRLGGGAGLLDPVSLGPLALGLALLILLVRRQKRRTHPLIDIAMFARPAFSTAVGCIVLAMLALVGLQLIAVQYLQLVLGLSPLETGLRLLPLTFAAMAAGATGSYTLRRVGPRRMVGWGFVLTASSVLLLTSMGHHDRPALLTVGFVLLGFGLQSTLFGAYESMLSDAPAERAGGAAAIGETSYQLGAGLGIALLGSVMNAAYAPGLASLRDQGVPARAGVEASHSLGEAYQVAAQLGGPTGDLLRSTARHAFVGGLHITLFVSAGLLLLGALAALRLPRAMDCPPKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z651</accession>
    <name>A0A7K2Z651_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000013">
        <property type="protein sequence ID" value="MYW27783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14403" checksum="208CC47A9D1589C4" modified="2021-04-07" version="1">MPWRSQAHVHIRREQGALVVTAHGDFDADEGDLLPAACNEADQQALPVTVLDLSGVTFGDSSFLDALLRARLVHHAAGRRLVLVGPLQQAVITLLTVTRVLEHFDIADTLEQALGGEPPPRRDGVGVGPGDGAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6L5</accession>
    <name>A0A7K2Z6L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FxsA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000065">
        <property type="protein sequence ID" value="MYW27985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FxsA"/>
    </dbReference>
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        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21427" checksum="5B192AB1D22CD3E9" modified="2021-04-07" version="1">MTTGTPPPTRPRRSRARRFLPLALAAWLVLEIWLLTMVASAAGGLTVLLLLVAGAVLGTVVIKRAGRRAFKNLTETLQQMPGRPGATEAPQVTGGKASQGNGLLMLGGLLLLIPGLISDAAGLLLLIPPVRAAISRRAERSLERRMRAASPGSLSDAFQQARMHRPDGKVVQGEVIRGDGTQPPSRPSGPDDDPRGPRPPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z742</accession>
    <name>A0A7K2Z742_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_02505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000109">
        <property type="protein sequence ID" value="MYW28170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="210"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="281"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="421"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="551" mass="60204" checksum="86554CCC055C77BE" modified="2021-04-07" version="1">MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQTVADGIVTGLGYELGCVNLVRPDGDLVIAAFAGNAAAEALITGRVGSRASWDRRLTMGEAWDQLRFIPHTEGWVLLDDDVPQWHTEGPEPRFEDEWHPLDRLYAPMYASGGGRDLLGVISVDRPRNGRRPGAWGREALQMYASQAAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLRTNDALCRLLGRPASVLRRYSFADLVHPEDIGTLLRTSAEGGRAELRLARRDGTYLWVSLRNSVVADTADGPRFLLTHVEDIEERKRHELNLAHRASHDALTGLPNSAELKSRLSARICERPNSPAATAIEALDAAYGDVESSLTHGYQADGYEGEAGPGGGPWDHHVHTLAPDAEHDDGTKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLSTCVRDGDTVARLGGDEFVVLADGLGAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMSVEEVLRSADQRMYVEKRSRSKVHRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7P6</accession>
    <name>A0A7K2Z7P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPFH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000150">
        <property type="protein sequence ID" value="MYW28379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="91"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="34326" checksum="8EC1DE48DD3F44DA" modified="2021-04-07" version="1">MTAQHDGHHPDASAAALDIDAPDMPEPQVREVTAHSIPGGLGLLLTVLGVFAGVGLAIVGGVIGAGGNNAVGVPLFILGVLLVITSFFCMSGVKMVAPGEARVIQLFGRYVGTIRADGLRWVNPLTSSRKISTRVRNHETAVLKVNDAYGNPIELAAIVVWKVEDTAQALFEVDDFLEFVATQTESAVRHIAIEYPYDAHEEDGLSLRGNAEEITEKLAVELTARVKAAGVLIIESRFSHLAYAPEIASAMLQRQQAGAVVAARQQIVEGAVGMVEMALDRIAEQGIVELDSERKAAMVSNLMVVLCGDRAAQPVLNTGSLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8N5</accession>
    <name>A0A7K2Z8N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_05360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000247">
        <property type="protein sequence ID" value="MYW28710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="173"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="273" mass="29420" checksum="6B6D48A89B2AB2E0" modified="2021-04-07" version="1">MRVMPTAGEAEPSATRETRSLPAHAPGAVDTPFVIKGYDEVVSHDTLWDAHSHPFHELLWNERGASSAVVGERIWTITPALGLWMPAGTLHSGSATAGTWFRASFFGFRTTSSISDTPVAVEITPLLRLLLERLGEPGLNPSSRAATEALVLDVLAPSPRELLVQVPTSALLRPIADAVRDDPGDQRTLVDWASELGVSTRTVTRAFSAETGTSFVRWVATVRAQHAIGLLTRGWDVESVAEQVGYRSASAFGVAFRRTTGLTPGTFRPELTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8T6</accession>
    <name>A0A7K2Z8T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloregulator ArsR/SmtB family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="13353" checksum="06B0632771E90DD8" modified="2021-04-07" version="1">MSKQELVVLGQDSTDECCPGLLAAPLDEDSATDLAKVFKALGDPVRLRLLSMIASRAGGEVCVCDLTPAFDLSQPTISHHLKLLKQAGLIDSERRGTWVYYRLLPQMTDRLAAILTRPADATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z936</accession>
    <name>A0A7K2Z936_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CGNR zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000267">
        <property type="protein sequence ID" value="MYW28857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18378" checksum="7345FAE62EF4E1DC" modified="2021-04-07" version="1" fragment="single">MRRNPAPAELEPVEAFCNSATLLQGEDELARPETAAGWLRAHDYPEVVSPADLAALAEARETVRAFLVERSSPGTLDALNRLIRSVAGAPAVRPDGTFALRPAGDGPVAEIVRTVLEALLRDGLTGRHATRLKACAAPECRWVFYDRAPSSNGLWCDMGVCGARHKMRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z953</accession>
    <name>A0A7K2Z953_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Choice-of-anchor A family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000270">
        <property type="protein sequence ID" value="MYW28863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026588">
        <property type="entry name" value="Choice_anch_A"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04215">
        <property type="entry name" value="choice_anch_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="368" mass="37445" checksum="A747F8A480C930F3" modified="2021-04-07" version="1" fragment="single">MATAAAMVGMLAPAAAADPLPGGLGPCLGSGCPDVWNEPNNGPIAGYDENINIYVGGDFLVREAAAEAEGKIVTLGQFDMDKRDGVSQVYNVGVVGVGSRVAPPNGSDYLTVGGDVTVAAGERLLAEEGANSGRVAYAGSLTGTVNPLTAPRPDPEATAPFTGLRPQLTEASRCYAYDGDAHRATTGSWTRAGDTFTFTGDNTSPIQVFDVDADLVSSTGGNAGFTFTGIPAGATVLVNVYGDARTVATFMGTLPNPGLRERLLWNFPDATALTLTGPAQFQGSVLVGQPASTTTLSMSGTNGRFYSAGSLTHTSSGASGGQEIHAYPFDGDLPTCGPDPTPTPTPTDPTPTPTPTDPTPTPTDPTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z957</accession>
    <name>A0A7K2Z957_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000260">
        <property type="protein sequence ID" value="MYW28835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="21146" checksum="236489C50B8F404C" modified="2021-04-07" version="1">MGAGFFHSYHLGWTRLDAATLLGDLEAEGLRPGHPVTGRTVLVSLDHPSSGARSPVTREQLLSLSGLQRLQEVGFRLWVDEGPDLLVRIRRARGGVVAVEFSVGELPPVERERAVSAIRRTVGRASVLCIGFVVDRSGATAGTDWDGVVIEGSAPLDSWPDAVAVREEIAHKHPQLTVMDSVAISPWKVFGSAVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9D8</accession>
    <name>A0A7K2Z9D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000302">
        <property type="protein sequence ID" value="MYW28971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="10237" checksum="9E21822C5BA84D12" modified="2021-04-07" version="1">MERQELVLIIEKALSEVLERPVSGLTEETALFDELQLTSLAVLGMLMSVEEATGISVDPEGLDIDDLRTLGSFADYVEAAIREEEIHKEEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA99</accession>
    <name>A0A7K2ZA99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-glyceraldehyde 3-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000376">
        <property type="protein sequence ID" value="MYW29263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="66" mass="7469" checksum="6805517C88C90DE4" modified="2021-04-07" version="1" fragment="single">MYLPSADRYSAMPYRRTGRSGLLLPALSLGLWHNFGGDRTPDEQGRILRRAFDLGITHFDLANNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAD3</accession>
    <name>A0A7K2ZAD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000385">
        <property type="protein sequence ID" value="MYW29294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15156" checksum="0CB11E81DD8F92B4" modified="2021-04-07" version="1">MDTVAFGIVPGYGEKLHDALGYSSAVRVGDRVEVSGQAGVDDDLNIPDSLEEEIVQAFENVGRALAAVGATWHDVIDVNSHHMVAPGEKVISEDVNRIMAQRFRLRLDGRAPIWTETGVTVLGLAAMRVEMRVTAIADSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAE2</accession>
    <name>A0A7K2ZAE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000385">
        <property type="protein sequence ID" value="MYW29303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="198"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="424" mass="43888" checksum="F11500330C366047" modified="2021-04-07" version="1">MGSTSENPPTALARTALELAAAHDSAATHRLYRELHAHPELSGAEHRTAARVRAALRAEGIDCTEGVGGTGVVGVLANGPGRTVLVRADMDALPVTEESGLPYVSTVDGIMHACGHDAHTAMLVGTAQALARGRQRWSGTVVLVAQPAEETGTGALAMRDDGLHRRFPLPDVLLAQHISAGPVGLVAHVEGPVLAASASIDVVVHGRGGHGSRPDTTTDPIVIGAAIVGRLQTIVAREIAPRETAVVTVGRFHAGTADNVIPATAELGLTVRSTSHELQTQILAAVQRIVRAECEAAGAKVRPGIRVVKSMPATVNDARVARNVAAVHTHMFGGDRIVDPGPAMGSEDFSELALLPDGQTLPYHYWFLPSTPLAVWNAAPGQSPMARFGNVPSAHSPDFAPDPAVLDHGVAAMTGAVLAELAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAI9</accession>
    <name>A0A7K2ZAI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046003">
        <property type="entry name" value="DUF5959"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19384">
        <property type="entry name" value="DUF5959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15623" checksum="9AFB0FCA8EC07AF3" modified="2021-04-07" version="1">MSGSSPTHLISLADSEGNSVTVSILGRNATWTAALDAEIVVSTPFVSGRLDLLLSVMDLDSWSAALDRLDAGEDAAWREMSRGPSLFIQLTGERECPEVVVEDEGWSMVTVRVPLVPPDDWIADHHRLLRRVMDHWAPMLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAJ4</accession>
    <name>A0A7K2ZAJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="17522" checksum="806411F97C50EBEF" modified="2021-04-07" version="1">MTAMTATASPAGAAAELRTALREAGLPVGATGTADYVQLGTLRASDARQLARLIRTGTKRILKAARALREICEAYGVDLPELRVRQGRITLGACRVGDAVRLARLLGASSPGPDVPDADAVRDLLAQAFSAATGGGTLDVSVREEASDVVELGALDARTARRLIGALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAL0</accession>
    <name>A0A7K2ZAL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-6y C5,15-methyltransferase (Decarboxylating) subunit CbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cbiE</name>
        <name evidence="7" type="ORF">GT040_08790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000405">
        <property type="protein sequence ID" value="MYW29373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="412" mass="42938" checksum="2B1714F8478D94BE" modified="2021-04-07" version="1">MADRVTVIGWDGSPLPGAATAALSAATLVAGAAHHLALPEVPRSAERIRLGSVDLAARRIAGHRGSAVVLADGDPGFFGVVRSLRAPEHGLEVEVVPAVSAVATAFARAGMPWDDAQIVVAHPRTLRRAVNVCRAHHKVAVLTSPGAGPAELALLLEGVHRTFVICEELGTDRERVTVLTSDKAADHTWRDPNVVIVIGGGPETTATGAWFAGREPAYPQGIRGWALPAEAYREAGAERMQESGEGESPNLRAAQLAILGPRTGDLVWDIGCGSGALAVEAARFGAAVLAVDADPGACSRTDAAARAFGVPLQIVCGRAPHVLELLPEPDVVRVGGGGVPVVRAVVDRRPERIVTHASTRDEAEALGAALTGNGYTVACSLLQSVDLDTEVWTERERSVVFLLSARRSDVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAX3</accession>
    <name>A0A7K2ZAX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000444">
        <property type="protein sequence ID" value="MYW29517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="292" mass="32179" checksum="E3FA5E755C8F6EA5" modified="2021-04-07" version="1">MSVVGDGTERGDAGVDEPGWEVDPDDEPGAAVVAAVGRQIKAWREAAGMRAAEFGTAMGYSEDLIYKVEGGRRIPRPEFMDGADGVLGAAGKLAAMKADIAEVRYPKKIRELAKMEAAAVELSAYGSHNIHGLLQTEEYARALFGMRRPAYSQDEVERLVAARVARQSIFSRSPAPELSFVQEEVTLRRHLGGRMVWRRQLERLLEVSELRHVEIQVMPTSRDEHAGMGGEMQVLKFKDGSAVGRSEGDFGSRPVSDPKYLRIIELRCGIIRAQALNPRESRAFIEQVLGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAX4</accession>
    <name>A0A7K2ZAX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000446">
        <property type="protein sequence ID" value="MYW29521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="540" mass="57024" checksum="7DC653C51D355CF9" modified="2021-04-07" version="1" fragment="single">NGTTHTYAGPSADAPTLRLRRRGGDFVPLLLRTPAPTPPVAPTPETPAPVPTTKVSEAPATSGTSAPEPSTAGDPPGPHGEEEAYGFSTLSGAEPRPQDSPDSDSDSDSDSESVGTTPVWADPEWLTALFGPQWNRAPRARLQETSEALYALVEEAADGRPVRDGLADLVREVMHLPDRARVTNQDVLDLGSLALEASSDDLADAEDLAVYFVDRQIETRRDALAEETLLHTADRTPAGRDLTGTGRGLPQPDSYLTERSGRVAEQNAQWRNPYLIVGQAAEGGGVEIVTPWRTFVVRDAEEMARIISYDTRRPGGADIVLALPPAFAARVANLVAGTTARPVWYPLGPAEVATHPTTGAAHLVVHRGDGETGPDWSTPPPPQLPGLPGARDLSSDSDSDDGRSSDSDSTSDGDAEFDRLADEAQFERRIDALRARPLITRDYEVVDDGGTGVLFTEPGPRAVGVVRAQEGTEGLALVLPHQGQDVVPAADRPPLHISADRTVALHSAGNDTTGRGRQVYATRAAIESSSARLAAAGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB07</accession>
    <name>A0A7K2ZB07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000444">
        <property type="protein sequence ID" value="MYW29514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="146"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="283" mass="29293" checksum="FC3893EA91DE6CAE" modified="2021-04-07" version="1">MTPLVALAVLVAAITHASWNAIAHAIKDQLLSFTLISGGGLLIGAAMALFVPLPAAEAWPYLGVSAVLHVAYMMLLMRSFTLGDFGQMYPIARGTAPLVVTVLAAVFVGERPDAWATTGVAVASAGLVGLALWGIRGSGTRPHWPAIVAALGTGLAIAGYTTVDGVGVRASGTPLGYVAWLMILEGLAIPAYAFYRRRAELVIQLRPFAVRGLLGAALSVVAYGLVLWAQTRAPLAPIAALRESSIIVGAAIGTLFFKERFGAPRIAAAGLMVVGIGLMLHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBB0</accession>
    <name>A0A7K2ZBB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_09995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000459">
        <property type="protein sequence ID" value="MYW29598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="235" mass="25411" checksum="3C1906946C580449" modified="2021-04-07" version="1">MNTLALGPSWLDPDYLLNTFGLPGLLLIVFAESGLLIGFFLPGDSLLFTTGLLVTTGQLKYPLWLVCTLIAVAAIVGDQVGYLFGRKVGPALFKRPDSRLFKQENVEKAHEFFEKHGPKSLVLARFVPIVRTFTPIIAGVSRMNYRSFITYNIVGAILWGVGVTVLGALLGKIDFVHENIEMILILIVLISVVPIVVEVLRARSQGKKAAAAEALGAPDGPPAPPATGRGRHAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBE4</accession>
    <name>A0A7K2ZBE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_10390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000481">
        <property type="protein sequence ID" value="MYW29676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14947" checksum="9C1ECEC042F6BA2B" modified="2021-04-07" version="1" fragment="single">PTNPPPPPEREPSAPRLSPGEAFDALYAHAAPGLVRQTYLLTGRRSLARESVERAFQLAWHRWPEVAVDRDPVGWVRAAAYEYAMSPWHRLRRVHRHPDAPPSEPARRALFEALLELPPAYRRTLLLYDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC77</accession>
    <name>A0A7K2ZC77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase subunit 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_11615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000540">
        <property type="protein sequence ID" value="MYW29912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9056" checksum="7E9A5D1D7CE6878B" modified="2021-04-07" version="1">YRVSPHSNRVGLRTEGPALERARDGELPSEGMVLGAVQVPPDGRPVVFLNDHPTTGGYPVVGVVPETALAGAAQAAPGTRVRFSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCM5</accession>
    <name>A0A7K2ZCM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000574">
        <property type="protein sequence ID" value="MYW30058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="23300" checksum="D4A2643A9CA8396D" modified="2021-04-07" version="1" fragment="single">PVGAALALPGLVSGGAVRQAPNLGWNEVPAQDLFGDALTALRPGRPVLPVASENEANLAALAELWFGGLGDVRSFLYLTGEIGVGGALVLNGELLRGAHGFAGEIGHVVVDPDGPECRCGSRGCLEQYAGQSALLRAAGVDGPGAGGGSGVLELERRTRAGDERAVAAVAEAGRMLGRVVSGAVNLVDPDAVVLGGIYRGLMPWLSPPADEELTGRVVSGLWSPGSGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCS7</accession>
    <name>A0A7K2ZCS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000600">
        <property type="protein sequence ID" value="MYW30156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029446991" description="LTD domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="802" mass="83510" checksum="54C71FC03F8C9AE4" modified="2021-04-07" version="1">MQISRSGSVLLTGAVAVTLAVTALPAAQAAPSATAVISEVYGGGGNSGATLTRDFVELANAGSTPFEVGGFSVQYLPGAPSAGSQWQVSALTGAIAPGGRYLIAQAAGTGGTVALPTPDATGTIAMAAGSGTVALVSGTTPLTCKTAADCGAEPRIVDLVGYGSAVVREGSGPAPTPSATASVSRAASLADTDDNAADFSASAPTPVNAAGETSGGGQEPEEPGPTEPGTVRIHDIQGTTRVSPLDGTAVTGVPGVVTGVRATGSRGFWIQDTAPDDDPRTSEGLFVYTGSAAPAVKVGDAVLVSGKVAEYYPGTGTQSITQLTAPRTTVLSSGNALPAPVVLDARSVPGRYVPSAGGGSIDALPLEPKRYALDLYESLEGVRVQIADTRVTGATTAYDEIWVTVKPKENPTRRGGTLYASYTDQNTGRLKVMSLDPAQPVPTADVGDVIKGRTTGVLDYASYGGYNLQATELGTHVDKKLRREVTRKQKKDELAVATYNVENLDALDPQDKFDTLAEGIAKNLSSPDIVSLEEIQDDNGPVNDGTVGSEATLKRFTDAIIAKGGPRYAWRYIAPENNKDGGEPGGNIRNVFLYNAQRVSFADRPGGDATTAVEAVKTWKGARLSVSPGRINPASPAWDSSRKPLVGEFTFRGKPVFVIGNHFGSKGGDQPLHGRFQEPNRSSEAKRIQQATEVNAFVTSLLKADKSARVVALGDFNDFEFSPTFTALTQGKVLKPLIKTLPASERYSYVFDGNSQTLDHILTSPAVRRFDYDVVHINAEFADQASDHDPQVVRVKVGGFWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCU9</accession>
    <name>A0A7K2ZCU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000607">
        <property type="protein sequence ID" value="MYW30201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="139" mass="14674" checksum="FBFA3C6634955C23" modified="2021-04-07" version="1" fragment="single">MRSCPACGTANREDDDFCGNCGSYLGWSTEPRRTPPTPLPEPEPEPEPEPAHPPAPEPQPQPTPQREPEPSPDPEPESEPTPAPAPTPTPTPTPTPVTAPVPPLEPPRPTPVRPAPPTTPPVRPAHPAQPTPTPAPTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCW3</accession>
    <name>A0A7K2ZCW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="6">HIU hydrolase</shortName>
            <shortName evidence="6">HIUHase</shortName>
            <ecNumber evidence="6">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uraH</name>
        <name evidence="8" type="ORF">GT040_12625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TR_THY" evidence="7">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="13634" checksum="E4DD32407518D35C" modified="2021-04-07" version="1">MSTDTTASVSTHILDTSIGRPAASVAVSLAARSSSGAPYVTLGASATDADGRCKDLPALPEGTTHVRLDFDTETYFSKKQAEAQQDAPRVRDSGAFFPEVTIAFAVVPGEHYHVPLLLNPFGYSVYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD62</accession>
    <name>A0A7K2ZD62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000616">
        <property type="protein sequence ID" value="MYW30238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="65" mass="6263" checksum="2EF9E98FEFE2C508" modified="2021-04-07" version="1">MSTFPTPAALRGAGGLSESDPGRALSTLAPVAATPGVLAGVAIGVALVNAFAAGYNHSGNVELPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDC0</accession>
    <name>A0A7K2ZDC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000657">
        <property type="protein sequence ID" value="MYW30360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="316" mass="33674" checksum="0ED11D5A8A7AB8BE" modified="2021-04-07" version="1">MAQQENTKRTIKPNTKRSSKRGTAPHGTTLRRTLRREAPSTVGLLVDAQDFAAMRRYRTFPFDDHTAYLHQVEGLLKSLAAQGMHTTVALFDPEEYADFCAESGLDADSGASRSRFTAEIAAAGATVAYTGQSLTDLIPLLVSRAVRQATWEYATLLLADLGACAECGQDIGRAAFDRASHLLTRLLETAGPGTHHLVCSTPTENDQLLAVLHTHRDATGPARLDTSEGAEFATVLAVAIALETPGGVVLRTSTPDSPDRVHGWRLAYGALAPLTAGEVFNAYCTDAETGEPVSPESGVEYSAGFDIGADPAEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDF5</accession>
    <name>A0A7K2ZDF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000657">
        <property type="protein sequence ID" value="MYW30362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="13772" checksum="57391D3E8CFF558F" modified="2021-04-07" version="1" fragment="single">MDGRDLVRRVRLVGSVRGVRTLRAAWRRRSADARALPPRGAERARVPGALVGAEPGPGGGVVRFARSELRIRVAVGGAVFWAWDGADPLPSYALAGEVPAADPRAVLEPDKDGGWQVVSERLTVVVSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDQ7</accession>
    <name>A0A7K2ZDQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000674">
        <property type="protein sequence ID" value="MYW30459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="12006" checksum="D48D8F9F07F3090F" modified="2021-04-07" version="1" fragment="single">MRMGIGTGIGTGIGMTEEHRALAHSVRGWLARAVPPGEVRKLLDAGSPGPCGVRPAYWEALAGQGLTGIQLPEEYGGGGGGLLDLAVVLEEAAYGSLPGPYLATALTGAVVRRAAGAGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE59</accession>
    <name>A0A7K2ZE59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_HSP20" evidence="2">
        <location>
            <begin position="151"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23852" checksum="A21077CB3014F735" modified="2021-04-07" version="1">AARKDEELAAVQALVEDGSTTLRLAAEPGPAAEDALRTARTGLALYGLRADLLVANRVLPRHSSDPWFADLAAQQEKCLGHWHEEWAPHVPVHEAAHLGRDPRTADDLAALAVPAPDERGPGRVDDPWWIEEEEPGDEEPGGEGRPSVLAWCLPLPGATKEELRLVRRGEELLLTVGPFHRIVRVASALRRCTVSGAALTDGVLRVRFTPDPALWPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEF6</accession>
    <name>A0A7K2ZEF6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Alanine dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ald</name>
        <name evidence="13" type="ORF">GT040_15775</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="WWKE01000733">
        <property type="protein sequence ID" value="MYW30698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="11">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW30698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="371" mass="39196" checksum="B99D70F107B3BCEE" modified="2021-04-07" version="1">MKVGIPREVKNNEFRVAITPAGVHELVRHGHQVVIEKDAGVGSSIPDQEYVAAGAQILGTADEVWATADLLLKVKEPVAEEYHRLRKGQTLFTYLHLAASRECTDALLASGTTAIAYETVETAGRALPLLAPMSEVAGRLAPQVGAYHLMRSVGGRGVLPGGVPGTHAGRAVVIGGGVSGWNATQIAVGLGFHVTLLDRDINKLREADKIFGTKVQTVVSNAFELEKAVVEADLVIGAVLIPGAKAPKLVTNELVAKMKPGSVLVDIAIDQGGCFEDSHPTTHAEPTFQVHGSVFYCVANMPGAVPNTSTYALTNATLPYIVELANRGWADALRRDAALAKGLNTHEGQVVYREVAEAHGLPHVELSTLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEH0</accession>
    <name>A0A7K2ZEH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000757">
        <property type="protein sequence ID" value="MYW30754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="47" mass="5342" checksum="CFDC64D705034894" modified="2021-04-07" version="1">MTQRTNVPGTVTVHRLDLGFFVRPTRTMPPARRTMKERSRSVMPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF00</accession>
    <name>A0A7K2ZF00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RtcB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_17015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000804">
        <property type="protein sequence ID" value="MYW30931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="162"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="397" mass="43564" checksum="26AE685F235C098A" modified="2021-04-07" version="1">MSYVEVPGAKVPIRMWTDPASVEDVAMQQLRNVSTLPWIKGLAVMPDVHFGKGATVGSVIAMQGAVCPAAVGVDIGCGMSAVRTSLTANDLPGDLSRLRSKIEQAIPVGRGMHDGAVDPGRLHGFPTSGWDDFWGRFDGIAEAVKFRQERATKQMGTLGSGNHMIEFCLDSDGSVWLMLHSGSRNIGKELAEHHIGIAQKLPHNQGIVDRDLAVFISDTPQMAAYRNDLYWAQEYAKYNRAIMMGLFKDVVRKEFKKAKPVFEQEISCHHNYVAEERYDGADLLVTRKGAIRAGSGEYGIIPGSMGTSSYIVKGLGNEKAFNSASHGAGRRMSRNAAKRRFTVRDLEEQTRGVECRKDSGVLDEIPAAYKPIEQVMEQQRDLVEVVAKLKQVICVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF66</accession>
    <name>A0A7K2ZF66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000809">
        <property type="protein sequence ID" value="MYW30976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="76" mass="8308" checksum="25F49B40CB8A6AF2" modified="2021-04-07" version="1" fragment="single">MAASVLVATTSEVLAHPDLDEGMLAPWEQRRLAYIRVPGRRDDVVAARLLLRLCAARVIGRSPREVEPAQRCPGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF86</accession>
    <name>A0A7K2ZF86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">ftsZ</name>
        <name evidence="11" type="ORF">GT040_17435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000815">
        <property type="protein sequence ID" value="MYW31013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="9">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW31013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="407" mass="41753" checksum="52B83CC8E4A44D78" modified="2021-04-07" version="1">MAAPQNYLAVIKVIGVGGGGVNAINRMIEVGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPAVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFTFEGRRRANQAEDGIAELREEVDTLIVIPNDRLLSISDRQVSVLDAFKSADQVLLSGVQGITDLITTPGLINLDFADVKSVMSEAGSALMGIGSARGDDRAVAAAEMAISSPLLEASIDGARGVLLSISGGSDLGLFEINEAAQLVSEAAHPEANIIFGAVIDDALGDEVRVTVIAAGFDGGQPPARRESTLGANTNKREEPAAPARPSAESARPSGGLGSVPPREESPAPAEPAPASASSESPLSQVSPPHVPPARPYQDTQAEELDVPDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFF2</accession>
    <name>A0A7K2ZFF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000846">
        <property type="protein sequence ID" value="MYW31094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="357" mass="39675" checksum="F9E6B20B42E62195" modified="2021-04-07" version="1">MATEVLWYIIPREGAYPWEPAGRRPTDLGYLTRLAGTVEQLGYSGALLATDLHDVWPLGSALSAATSTRFKPLLAVHPGLISPTLLAKMALTFDNLFGGRLRFNVVNGSTKSLQEYGLHVEHDERYELSAEYWSLVKRLTAGEVFDHQGRFYDLKNAGASFRELKPVQDPHIPLWFGGSSAPGIEMAAQHVDVFLTWGEPPHLLKEKLEQVRARAAAHGRTLRIGLRLHLIVRDTEDEAWAAADRLLDVTSEATYARQLGDRAGEDGVGWQRQFRQHGGRVPARARELETHPNLWPGMSLFRPGPGTAVVGSTAQVTERLKEYEELGVDTFILSGNPLLEEAYRVAETVLPTLGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFM9</accession>
    <name>A0A7K2ZFM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000856">
        <property type="protein sequence ID" value="MYW31128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="167" mass="18123" checksum="9312D5A8FDBF01D4" modified="2021-04-07" version="1">MLEPLRQGLPPTDPSGVAGSASCALPARYEAVGGARQFTRSTLERWELSDRFDDVALVVSELVTNALRHALPSDPPREFQDPPVRLHLMRWSSRLVCAVRDPSRDSPVAGEAADSAESGRGLFLVECVSDSWGWHPSPAPAGELPSVPAYGKVVWALFRLSDCTKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFN6</accession>
    <name>A0A7K2ZFN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobaltochelatase subunit CobN</fullName>
            <ecNumber evidence="1">6.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobN</name>
        <name evidence="1" type="ORF">GT040_18135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000857">
        <property type="protein sequence ID" value="MYW31140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1201" mass="129574" checksum="8DAF450452C338DD" modified="2021-04-07" version="1">MILLLSTSDTDLLSARASEGPVGYRYANPSRTDLAGLPALLDGVDLIVVRLLGGVRAWEEGLDAVLATGRPVVVLTGEQAPDAQLMAASTVPIGIAAEAHAYLAHGGPANLEQLARFLSDTVLLTGHGFEPPAPAPAWGPLERSARAVPDGAPTVAVLYYRAHHMSGNTAFIDALCTAVEDAGARPLPLYVASLRTPETELIDALRAADAIVTTVLAAGGTRPAEASAGGDDESWDAGALTGLDVPILQALCLTSPRAAWEENDEGVSPLDAATQIAVPEFDGRLITVPFSFKEIDEDGLPAYVADAERAARVAGIAVRHAKLRNIPNAEKRIALVLSAYPTKHSRIGNAVGLDTPASAVALLRRLRAEGYDFGPEADIPGLVSGDGDELIYALIEAGGHDQEWLTEEQLAKNPVRIPAADYRRWFARLPQELRESVEEHWGPAPGEMFVDRSANPEGDIVLAALRRGNLLILIQPPRGFGENPIAIYHDPDLPPSHHYLAAYRWIAASADDNGFGADAMIHLGKHGNLEWLPGKNAGLSAACGPDAALGDLPLVYPFLVNDPGEGTQAKRRVHATLIDHLVPPMARADSYGDIARLEQLLDEHAQIAAMDPAKLPAVRAQIWTLIQAAKLDHDLGVADRPEDEGFDDFIMHLDGWLCEIKDVQIRDGLHVLGNPPAGNDRVNLVLAVLRARQIWGGTASLPGLREALGLDESAATRTAADAIEDQARALVQAMDDADWEPAAVAEVAAGLPDAVADILTFAATEVVPRMAATTDELTHAVHALNGGFVPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSKLAWETGQALADSLLTRYRTDNGDWPTSVGLSLWGTSAMRTAGDDIAEAFALLGIRPVWDDASRRVTGLEPIPHEELGRPRIDVTLRISGFFRDAFPHTIGLLDDAVRLAASLDEPAEQNYVRAHAQADLAEHGDERRATTRIFGSRPGTYGAGLLQLIDSRDWRTDADLAEVYTVWGGYAYGRELDGRPAREEMETAYKRIEVAAKNTDTREHDIADSDDYFQYHGGMVATVRALKGKAPEAYIGDSTRPETVRTRTLVEETSRVFRARVVNPKWIEAMRRHGYKGAFELAATVDYLFGYDATTGVVADWMYDKLTETYVLDPENKRFLQEANPWALHGIAERLLEAESRGMWAKPDPAVLEALRQVYLETEGNLEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG30</accession>
    <name>A0A7K2ZG30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000888">
        <property type="protein sequence ID" value="MYW31317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="17929" checksum="1394A86D8EFBA514" modified="2021-04-07" version="1" fragment="single">MTSLEPPRSPEQRLRDTLDRLRDDEDAWVATASSEGAPCLVPLSFVWHGDALVMATRRTNPTAVNVTPTGAVRVTLGPTRDVVLIEGEAEIVEGTDLPTATGDAFAAKLTWDPRKDSRWVYLRITPYTVRAWREVNELAARDLMLSGTWLVRPSSATSPTSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGC2</accession>
    <name>A0A7K2ZGC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000906">
        <property type="protein sequence ID" value="MYW31358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6554" checksum="2E1FD0530B6DE87E" modified="2021-04-07" version="1">MSTSELAWFKSSYSGSQGDDCVEVAQGTRAVHVRDSKDLRSPELAVSPAAWGDFVTYAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGN9</accession>
    <name>A0A7K2ZGN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SigB/SigF/SigG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_19885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000926">
        <property type="protein sequence ID" value="MYW31475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="35375" checksum="BCF8E96D20618FA1" modified="2021-04-07" version="1">MSPRLDEARTPHASSACPQGPTNSDSHAATAVPGPRTSSTSTTPDSSGEGLEVFTGLEGLPEIPPYAEVGALDARALSKTLFERLESLEEGTHEYAYVRNTLVELNLALVKFAASRFRSRSEPMEDIVQVGTIGLIKAIDRFELSRGVEFPTFAMPTIVGEIKRFFRDTSWSVRVPRRLQELRLDLAKAGDELSQQLDRAPTVAELSERLGITPDEVVEGMSASNAYTASSLDAKPEEDDSEGALADRLGYEDHGLEGIEYVESLKPLIAALPSRDRMILSLRFVSNMTQSEIGEELGISQMHVSRLLSRTLVKLRKGLTLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH22</accession>
    <name>A0A7K2ZH22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000976">
        <property type="protein sequence ID" value="MYW31640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="22517" checksum="5D0CDBCA5CD42598" modified="2021-04-07" version="1">MGAGTALRLVRTALFAVVCVAVSGLGHALMSGGPLPLPPLPAVLVPVAAAGWLLARRERNAPVTVSAHVLGQLGLHAYFTVYATGGAHHAHGAMPHATHAGPVGDVSHRMELLAAFDASVFTTGMAASHAVAGLICGWWLWRGEMALARLGRCLAYFVRTPLRTAWRLWSATPLDGGPSSRPRTRRRPGRRLQDLLALHAISRRGPPLPVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHF6</accession>
    <name>A0A7K2ZHF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001016">
        <property type="protein sequence ID" value="MYW31791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="11658" checksum="882C279E964AD5A1" modified="2021-04-07" version="1">MRPSQEPSMGTSATPIYDALYSEYRRSFRALPGDRSGEENLRFPAFGAGLFASRAPLGGGHPSPAGQSRHTGNGSSVQSQHTGTLGSWQRVGRHAGRPRPAALPPGTRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHF7</accession>
    <name>A0A7K2ZHF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rplI</name>
        <name evidence="9" type="ORF">GT040_21375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513854.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001015.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="15708" checksum="6F8B3A8EAC6097FA" modified="2021-04-07" version="1">MKIILTHEVSGLGTAGDVVDVKDGYARNYLVPRGFAIRWTKGGEKDVAQIRRARKIHEIATIEQANEIKAKLEGVKVRLAVRSGDAGRLFGSVTPADVASAIKAAGGPDVDKRRVELGSPIKTLGGHQVSVRLHPEVAAKLAVEVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHL4</accession>
    <name>A0A7K2ZHL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001022">
        <property type="protein sequence ID" value="MYW31834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="20796" checksum="B7980CF1E4C80E9C" modified="2021-04-07" version="1">MDTEEATTAAETPPAADGSRWFYGCWIAAIALLALFALAAHAVTEFEKSLDGDGQMEQPGRSGSAYQPLGPGATARYEDGLRVTASVPEAHDDGTYSLTVTYRNATDEDLALDGDSYSASLAVRAGEADDEYATGYTVRQLDGAKSAAALAQPLPEDDERTVPLRLKPSRKGIPVTVEVSTPTPGSRDTAHFQLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI43</accession>
    <name>A0A7K2ZI43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_22290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001060">
        <property type="protein sequence ID" value="MYW31929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="130"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="37905" checksum="C657EBC22D5B518E" modified="2021-04-07" version="1">MTSPIEAEDATASVALDEKPAAKTTAADAEAPVGRSPGQLMWMRFKRDRTGVVSAIVVILYFVIALLAPVIASLYGKNPYTLYAQEPEYPFLLDDFAMPTGTFGGISGEFWFGVEPTLGRDVFTMLLYGMRTSLYMAVALTVLSVGTGVVIGMVSGYFGGKVDYWLGRITDFFLAFPSQLFFIAFMPVVTALFVSPTDETPTYLRAVAIIMVMWFLGWMGMARLVRSSVLSLREREFVEAAKVSGASRWRIVRKEILPNIVTPILVQGTYMLPSAILSIAFLSFVGVGFVEPTPDWGRMFATGAKIYEQDPSFMLFPGLALVIFVLAFNLLGDSVRDAFDPKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIF0</accession>
    <name>A0A7K2ZIF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="351" mass="38380" checksum="792D4DD196E4CB80" modified="2021-04-07" version="1">MIDRIEALLDEGVRDKVYPGAVWAVGDSTGTKASGCTGALDPDEPEHRMQLDTVFDAASLTKILAVWSSIGALWEDGHLDLDDQLATHWPEVTGYELGQVTARQLLTHTAGVPLRAQLKNQYGTNHDDIRKGVLREPLHRPPGEAVEYTDRAALILGFLAEHLSGMPLDQLVTERIWQPLGMGTTRFGPLPTDLAARCAPTELDQETDTHLKGVAHDFSARLLGGVCGIAGAFTVLDDLANFLRHMLAPSTDGVTVGLGPSWIAQSLTIQTSGLEPARGLFWHPATGTSEADDMWVHYGFTGTGMWISPTTDRWAILFTNKLYYTRDRQPLTNVRNAFRSLSFAPSCLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIF7</accession>
    <name>A0A7K2ZIF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="421" mass="45522" checksum="6A82910B3FD64058" modified="2021-04-07" version="1">MADAYDEAKRLGEVLRRARVLARRSQADVATALGYHQSKVSRLEQGKGTEDSQVLRAVARELGIPLASVGLADVPDTRNLKPETDDMHRRNFLAASLATLAAPAVPSHAGSGALVQALLPGPIPPAQDEDQNLPQLGERISEVRRLFYACDYTRLEGTLPSLIIDLRNAAARSDEAAGLLATAYQTSASLLLKRGDHGNAWLAVGRAMAEAERSGDPVVLASSVRVHTHLLARELHTSQAITLVRHTADQLTGAYDQRSPRYLAALGLLLLRGVTAASSGGDRAATHDFLTEAKEVARYVALDRADAWANFSPTNVSLHEVSATVAFGDAGLALEAARPLMRRHIPAPERRAALWVETARAYSQQGRLADGYQALRIAESCAAQDIRRPAIRELVADMAARDRRRTLPELHHFSRQLGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIK3</accession>
    <name>A0A7K2ZIK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="272" mass="29398" checksum="EDBBBC8C95A4756C" modified="2021-04-07" version="1">MGRQININGAPQGPGKPDTAVALARSIDQLPTKQLADTPVLIAQEQQLLVRCEAALENLRVAYWAAGKALQVIRDGRLYRATHDNFEDYCQEQWDISRQYANQLIRSWKIAEKLFEMVGGKSNDLERILSKKLGFGQAWELVALAEEHSVDAAALLYLALIQVKGMGVTANLVKGAAGSLPSAAAGKKKATEEAVLAYLASIEGKTELPAARDPYKALTRATKKLDPDTLQAAMERNPEGTRTMVRELIEALSASVGIEVEIKASAAESSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ43</accession>
    <name>A0A7K2ZJ43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-dicarboxylate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_24585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001153">
        <property type="protein sequence ID" value="MYW32357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="392" mass="40039" checksum="1981D7DCC8CD4BE9" modified="2021-04-07" version="1">MAIFPQTRTAEPLLPPDAWTGPRPVVRRLPSLRHIGPNWYASVMGTAIVASAGAALPVDVPGLRGACTVVWALSAVLLAAVLAARAGHWLHHRDQARAHLLDPAVAPFYGCLAMALVAVGGATLTVGADVIGVRAALAVDVVLFIAGTAVGLVAAVVVPYLMVVRHRPAPGTASPVWLLPLVAPMVSASQGALLVPHLAAGQAREALLLACYAMFGLSLLATLVVLPLVFARLVHHGPLPLALTPTLFLVLGPLGQSTTAVNQLADAAPGAVAGPYASAFGAFAVLYGVPVMGFALLWLALAGAMVLRATRDGMRFAMTWWAFTFPVGTCVTGAAGLARHTGLDALTWLAVALYVFLVVAWAVAGARTVGGVVSGALTAAPAPPGAATARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ63</accession>
    <name>A0A7K2ZJ63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3068 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001158">
        <property type="protein sequence ID" value="MYW32400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="327" mass="35894" checksum="0853AA2B250E8AD2" modified="2021-04-07" version="1">MRRNASPLSLFLLGAGVFLLVLAPLLVWYVQPQAKRTPIDIDTTTVFTGTGSYFDTSKVETVEGKEITITRQVRGDVADSVKSGNAVWDVSTSVDHEGTLPASDPRDALQWTMERWVTDRTTNEPVHCCEETPTFDGEAYLKFPFDVERRAYRWWDGTLGGVVRLDYAGKKKVQGYEGYVFKGTVEPTRTGVRQVPGVLVGKPRTPQILAEEWYSNSGIELVVDRRTGRIMNAAIGPKKTLRAPGSKKDAVTLLESKRVEFTKETQLKQVELASADSDRLALLSGTAPAGAVGLGLVLATVGIVLVIRGRRTEPEAPNTHMMTNSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJC6</accession>
    <name>A0A7K2ZJC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001175">
        <property type="protein sequence ID" value="MYW32456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030566808.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001175.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="19264" checksum="31664DF2710AF222" modified="2021-04-07" version="1">MLDIGYSLSRRFPDPPQTDYRRADVRALRHDLFSGDVYLADTKADREVSTAWGWVPVLDFAWALCDIVEQIDQDPRGNRSHRRQYAELDFTESSDVMIFERRFGWVDVEADWMPGDEPPLTFGHSLLRREARDFLHDLIADLSDMHDGLADNPVIWDLQARFPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJN8</accession>
    <name>A0A7K2ZJN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001181">
        <property type="protein sequence ID" value="MYW32469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="179"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="327" mass="32804" checksum="664C77C7638E7C2C" modified="2021-04-07" version="1">MNVQPSASEPAAAAAVAVPEAVPALDTAGPKDPGPGPGRGTALVPIVLVVAGGLSVQFGSAVAALLMPKAGALGVVTLRLAAAALILLVVCRPKLRGHSRADWGTVVAFGVAMGGMNTLFYQALDRIPLGIAVTLEVLGPLALSVIASRRLINVVWAGLALVGVVLLGGGGFDRLDPVGAAYALGAGAMWAAYIVFSARTGRRFPQADGLALAMVVAAVLSLPLGIWESGAKLTVPSTLALGAAVAVLSSVLPYTLELMALRRLPASTFAVMMSLEPAIAATAGFLILDQALSTTDALAIALVIGASMGAVRSQTGARQPGARKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJT1</accession>
    <name>A0A7K2ZJT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore photoproduct lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001201">
        <property type="protein sequence ID" value="MYW32594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023805">
        <property type="entry name" value="Uncharacterised_Spl-rel"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03886">
        <property type="entry name" value="lyase_spl_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="391" mass="43806" checksum="3F762677C2A6FF4B" modified="2021-04-07" version="1">MNRPPEQPEQPEQQALFGWEDTLPADPPDRGGGFRDSPRARRMLNVREVYAEPAALASPRGRQILARLPGVPVTEVAGHWRIPSLHGNDGNIARWTRIKTETLVLGVRQSLTTRPNGRSADWIAPGASNGCAMACAYCYVPRRKGYANPITLFTNIEAITAHVRRHVRSQGPKAEPNQCDPHAWVYDIGENGDCSVDDLICDNTADLIAAFRELPTAKASFATKFVNPDLLALDPRGRTRVRFSVMPADDSRLLDLRTSPVAERIAAAADFLDAGYEVHFNLSPVVLRPGWQRDWAELLEQLDDVLPDRVKAQAAAEIIMLTHNQQLHEVNLGWHPRAEEVLWQPAAQETKRSENGALNVRYARDIKRDALARLRELIAEHAPWLRVRYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJY2</accession>
    <name>A0A7K2ZJY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001216">
        <property type="protein sequence ID" value="MYW32662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="12029" checksum="AB4CC8FDECA377AD" modified="2021-04-07" version="1">MNLAPLPSVDVAQVPLDGLVLDVRENDEWAAGHVEGALHIPMSDFVGRFGELTEAAGDGRRVHVMCRVGGRSAQVTQYLVQQGIDAVNIDGGMLAWDGAGRPMVTDDGASAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK56</accession>
    <name>A0A7K2ZK56_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsM</name>
        <name evidence="8" type="ORF">GT040_26540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510587.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001248.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="14272" checksum="08171B8B9D29A7F7" modified="2021-04-07" version="1">MARVSGVDIPREKRVEVALTYVFGIGRTRSKEILASTGVNPNTRVRDLAEEDLVKIREYVDANLRTEGDLRREVQGDIRRKIEIGCYQGIRHRRGLPVHGQRTSTNARTRKGPRRAIAGKKKPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKE2</accession>
    <name>A0A7K2ZKE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001244">
        <property type="protein sequence ID" value="MYW32719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="89" mass="9022" checksum="D61B0FDC1C00BBC3" modified="2021-04-07" version="1" fragment="single">MRTEPSAEWTPLPAYGEEAGPRPAPAPDAQTDKDKETSPGLGVNGDTGTDTGTDTDTGTDLDLVLDLANGPRATSATVSVSVPAPHPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKN4</accession>
    <name>A0A7K2ZKN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Threonine/serine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001278">
        <property type="protein sequence ID" value="MYW32901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="39" mass="3914" checksum="235B5E0C7DBB279C" modified="2021-04-07" version="1" fragment="single">MTAAGTRLGAGDVRAAAERIRGPVRRTPLLAADALPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKP6</accession>
    <name>A0A7K2ZKP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001295">
        <property type="protein sequence ID" value="MYW32926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045635">
        <property type="entry name" value="DUF6412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19950">
        <property type="entry name" value="DUF6412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="11635" checksum="028BC10766F905D4" modified="2021-04-07" version="1">MRDANRLRGAFARFLRPVGLLVLLLTEVLLAEGGSLSAAVALAATAAAGSALLACSVISARCAPPVPRTRVRTAIRDREKRTAFLPQRDPDARGRTRPRAPGHALLTAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKS5</accession>
    <name>A0A7K2ZKS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001263">
        <property type="protein sequence ID" value="MYW32849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003969624.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001263.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6214300"/>
    <dbReference type="GeneID" id="66956930"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="12432" checksum="7F8102BEF28DFFB0" modified="2021-04-07" version="1">MSVSDETTTVSDGILLSDAAAAKVKGLLEQEGREDLALRVAVQPGGCSGLRYQLFFDERSLDGDVVKDFDGVKVVTDRMSAPYLGGASIDFVDTIEKQGFTIDNPNATGSCACGDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL23</accession>
    <name>A0A7K2ZL23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001297">
        <property type="protein sequence ID" value="MYW32949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11034" checksum="B7EE15AB4FD19DF5" modified="2021-04-07" version="1">MATQVSKAVLVRLEALPGKEDDVRGFLNQGLSIVEGEPGTVRWFGIQFGPSSFGIFDAFPDDDGRQAHLSGAVAQALSERTGEFFEEPTIELIDVVVEKQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL46</accession>
    <name>A0A7K2ZL46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001311">
        <property type="protein sequence ID" value="MYW33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="221" mass="23585" checksum="ED81C7680B1B83DE" modified="2021-04-07" version="1">MHTPSLLFVDLCHRDTGTAIVLAGAMDSDSVHGFTTVMRDVLRAGTATVHLDLSALAFCDCGGLTALLRASQDSRREGRPFQAHAPSRAVLRLFTLTGTASTLLSREFPAGGALRPPLPSRTDLLLRPYDEELERWPLVLSHEMTQILRALHTGARPGLGADCVSALGMGHLCRVAGGRRPHHGTVVVLRSGGRRLRGSAVHLGARTWAGCPACRPGHRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL66</accession>
    <name>A0A7K2ZL66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001311">
        <property type="protein sequence ID" value="MYW33068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="293"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="529" mass="57066" checksum="4BD9DABFE1F7A541" modified="2021-04-07" version="1">RSGLAGVGVGVADSSRYYLGRPGERARLVAEEPGYAAVVGLAPGGRLLATAGDPVGPAAVRLWSPASGVLVDAIPGAAGDGDGGAVWALGFRPDLTTARPELLLVLERAGRYTLAFWRQGEGIRTHGPGSALDFDTEITACWYGPGRTALVQQDRAGRSRLLRADLDRGTTAVLPTPEGTIIDFSCAPDRTVHCLWSRDGEPPRSLICHPESMESAEHPESPERPGRSVTASRGTAPGGTTGSRRHELWTRRPYGQIHSFVASPPGRRAGHRPWPTVFLVHGGPHTHDRDAYDARTEALVQAGFTVVRTNYRGSTGYGPRWRDDFGHRVGLAQLEDLAAVRGHLIDAGVSEPGRTGLCGYSWGGYLTLLAMGVQPRLWDVGLAVAPVADYTAAYRATTPALREVDDRLFDGTPEQVPHRYRAACPMTYVGRVRGPLFLAASADDEKCPPEQIERYLAALRRRSVPHRVRWLGGGHDVGRDPAGHAAAWAAMVRYADDTLRASPRTADRRNSGRTGSHHPIHHTEERSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLF5</accession>
    <name>A0A7K2ZLF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_28350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="7">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12332" checksum="515CC18DAAF12213" modified="2021-04-07" version="1">MDTTVWLVVAAVAALIMLALAAVLLVRVFKARKLLVDAGIPLRNKALVWAAVVYTISPVDLLPDPVYLDDIGFLLLALRSLHSAASAAGLGRAKGAGAPVEIPNLDKTVEPRPDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLN6</accession>
    <name>A0A7K2ZLN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001360">
        <property type="protein sequence ID" value="MYW33265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8552" checksum="214EBFF72C283B3B" modified="2021-04-07" version="1">MEPTERRRAAAEKVRAAEDAVEQLKAGLAGLGVTLPSLRLDPVSCAGNEPTPLVDLGRCNIDTALRLCEVLAEKESGHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLP8</accession>
    <name>A0A7K2ZLP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001349">
        <property type="protein sequence ID" value="MYW33179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="58" mass="6718" checksum="BA64C3F8A5A342B8" modified="2021-04-07" version="1">MTTPELTMREKRPAERYGERTARPEKLRNIEVWARSAPIRLAGYEDDLAEPHILPGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLR7</accession>
    <name>A0A7K2ZLR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001359">
        <property type="protein sequence ID" value="MYW33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="158"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="494" mass="53310" checksum="956E3D761404C79A" modified="2021-04-07" version="1">MNRPLRHIAIFCGLLMLGLLLRANWLQQVDRVELSQHEKNHRVRFERFATPRGDIIVGGKAITGSKETESRDYTFRRTWKEGPVYAPVTGYASQAQGTSLLERTYDSVLSGQDDRFAFRHAKDVLTGQPRRGGSVITTIDPKAQKAGYKGLTDLGARGAVVALEPSTGKVLALVSTPSYDPGVFAGISFKESDRFKKLLDDKAKPLANRPLRETFPPGSTFKILTAAAALEHGVVSDVDAPTKAVSPYPLPLSRNKIGSEAGDGICNKASMKTAMQYSCNNVFLDAAAELGEDRMRETAEKFGFNEDVYAEEFGDMLATKSLYPAELDKPGTALTGMGQGSLTSTPMQMAMVTAALANDGKLMQPYIVEELKGPDLSTLETNNPAEMSQAVSPETAKKVQEMMEHTAKEGSAQRALIDGVTVGGKTGTAQRGVNVRDEVPYGWFVSYAKTDDGRSVAVAVFIDPTDMDISRSDISGGRLGAPIAKKVMEAALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM42</accession>
    <name>A0A7K2ZM42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="325" mass="34187" checksum="80C1466F96E57413" modified="2021-04-07" version="1">MTDMKQQRYDVVIVGGGAAGLSGALTLARARRSVLVIDAGEPRNAPASHVHNYLGRESTPPGELLAIGRGEVAGYGGEIVEGRVASAERLPGEGEDGFRVVLEGGSTVEARRLLVTTGLVDELPPVPGLAERWGREVLHCPYCHGREVADRPIGVLSTGPLAVHQALMWRQWSDDVTLFRHTGPEPTDEEYEQLAARGVAVVDGEVSGLEVTDDRFTGVRLVGGRVVAREALVIQARFTARSAVLESLGLVPVAQEMGGEVIGTYIPTDPVGATEVPGVWAAGNVTRLTEQVIGAAAAGLMAAGAINGDLIAEDTRTAVEARRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM67</accession>
    <name>A0A7K2ZM67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="37886" checksum="4F13FC57F3FC3C70" modified="2021-04-07" version="1">MQPGKQSGIRRVTSWQLVGAQLRHFRKLAGLTQAALAEQAGVGEDTIASIEQGRRALQVDLAIQLDELLDTKGVLRVAVEKIPRKERYQALVRDFVQYEQDAVSLISYESQLIPGLLQTEAYARFIFDCNYPPLEDDEIEKRVADRLGRQKILERKPRPLLHFILEESILHTELGDPDVMREQLLHLRRCMDLPFVTIQIMPRNTRRHAGLAGPLVLLETPDHDQLVYVDGQLRGELYDEPADVSALMQRYGMLRSQALTVEESSRLLDALLDALLGETCPAPHTPPPVPPPSTGSSPATATVTAATASKSPTTGESPATATVTAETASRSPLTPPPSTSATPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMA8</accession>
    <name>A0A7K2ZMA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001410">
        <property type="protein sequence ID" value="MYW33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21685" checksum="9C913F915DD03567" modified="2021-04-07" version="1">MEIRTWPDREAMLADRAFILGALVRMHLGPARLGVLVMWAGLAAFGWLLVGSGLVMFEQASADFFSGIAGLLTLLLGAGALIPAVVLVSLHLARDREIRALLVEWGALDRDPERDRDLRLPGMSLVWLLLSFVLAAGGLALCVIGPASARPGDDTYGMVALVMGLGMVAWLTGLIGAVKALAHRRWVLRVLAAPAPLDVPAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMF2</accession>
    <name>A0A7K2ZMF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001405">
        <property type="protein sequence ID" value="MYW33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="100"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="382" mass="40704" checksum="D37FCD35319F4B93" modified="2021-04-07" version="1">MTVPETTATTTATTAAAVGEASGAEALRPHAEDAFADELKALAAADDRPRPARWRLSPWAVATYLQGGTLPDGTVITPKYVGPRRLIEVAVTTLATDRALLLLGVPGTAKTWVSEHLAAAVSGDSTLLVQGTAGTPEEAVRYGWNYAQLLAHGPSRDALVPSPLMRAMADGMTARVEELTRIPADVQDSLITILSEKTLPIPELGQEVQAVRGFNVIATANDRDRGVNELSSALRRRFNTVVLPLPATPDAEVDIVSRRVDQIGLSLDLPAAPEGLAEIRRVVTVFRELRDGVTTDGRTKLKSPSGTLSTAEAISVVTNGLALAAHFGDGILRPGDVAAGILGAVVRDPAADRVVWQEYLETVVRERDGWKDFYRACREVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMQ3</accession>
    <name>A0A7K2ZMQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_31315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001437">
        <property type="protein sequence ID" value="MYW33635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030570198.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001437.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="23938" checksum="ED6AF2711564D587" modified="2021-04-07" version="1">MAIRVLLVDDQPLLRTGFRMILEAEGDLAVVGEAGDGLQAIDQVRALQPDVVLMDIRMPRMDGVEATRQITGPGKDGPAKVLVLTTFDLDEYVVEALRAGASGFLLKDAPANELVQAIRVVAAGEAMLAPSITRRLLDKYADHLPSGEDPVPDALHTLTDREVEVLKLVARGLSNAEIAADLFVSETTVKTHVGHVLTKLGLRDRVQAAVYAYESGLVRPGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMR6</accession>
    <name>A0A7K2ZMR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001438">
        <property type="protein sequence ID" value="MYW33654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="28518" checksum="232115D50EC839B6" modified="2021-04-07" version="1">MDIDAGLIPDPLKVGKGPGLLLAHGAGSDIQDSYGPVIERLSAVSTVVGPDFPGSGNCPLPQGPLTLNDTADYLVASAVRAGIESFTISGFSMGTAVAVRAASRHRERVTGLILSSGFAYPNSRLRLVIDTWRALARDTGNPRTLASYLSLVVGGPQWLDGRTPEEVEEQLALFSAGMPAGADAQLAMFDHIDVREDLRSISVPTLVISPLADLITTPLHSRELADGIPHAELVTLDCGHAIAAERPEAWADAMTKFLTALPRTGEPAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMW4</accession>
    <name>A0A7K2ZMW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001441">
        <property type="protein sequence ID" value="MYW33672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14123" checksum="E1EEBC281301C690" modified="2021-04-07" version="1">MVTHAAMPGRKGARAHARPRSLTPYAVAVPLALGIIYGFYAAFIRRDGGPSTGGQVVLGLVSGAAVAALCFALGRIQRTLPHGLRALAYGALTACAIGFLVSLTDTSVLRSIVLGLVVGVGVFLTTFYLFYSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNH0</accession>
    <name>A0A7K2ZNH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001489">
        <property type="protein sequence ID" value="MYW33880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="347" mass="38627" checksum="4AC8359A5DCC8D44" modified="2021-04-07" version="1" fragment="single">MKPPLLSVVIPVHNVEDYLEDCLRSVADQSLDAIEVVMVDDGSTDGSGRIAAAFAARDGRFRLVRQENAGLSAARNTGVRHTTPTVPYLAFADSDDFVVHDAYERMVASLESTGSDLVTGNVWRLTGQGRQQAWQYRWLTATRSRTHITRDPRLLADRVAWNKVFRRSFWDGHAFTFPEGKLYEDTPVMIPAHYLAGSVDVLHEHVYYWRVREGSITRRRTDVTGVRDRIAACEQVSAFLGEGGPGGAAQRRAYDASCLRDDFGYFLDGLPMGGDAYRTSFLEGAGAFVERAGDGVLEGLPAELRIKWRLVRERRLEELLAVLAFERANGAGTFAVEGLPGRRRAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNK6</accession>
    <name>A0A7K2ZNK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-carnitine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001497">
        <property type="protein sequence ID" value="MYW33925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="313" mass="32890" checksum="28D216293EAD0B0A" modified="2021-04-07" version="1" fragment="single">MSSPTPPVPAPCAPEDVRRVACVGAGVIGGGWAAHFLARGYDVTAWDPAPDAEARLRRLVAAAWPALERLGLAEGASQDRLTVTASLEEAVAGAEFVQESAPEKLELKRDLLARLDAAAPAGTVIASSTSGYPMTDMQTGAPGAARLVVGHPFNPPYLIPLVEVVGGELTAPAAVEWASRFYEVAGKSVITVDREVPGFIANRLQEALWREALHMVANGEATVREIDASITEGPGLRWAVMGPMLTFALAGGEGGMAHMLDHFGPSLKSPWTRLEAPELDRALYEAVVAGCDEAAAGRTIADLVAERDRGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNY4</accession>
    <name>A0A7K2ZNY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001507">
        <property type="protein sequence ID" value="MYW33979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029807740" evidence="2">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="46"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="322" mass="33434" checksum="DFB77C863726C1DC" modified="2021-04-07" version="1">MSRTSRIAGAVIGIVALTGSLAACGGDSLEKEKGSGSSGGDGKKGSLVVGSAAFTESKVLAELYAQILGDAGYSTSITTVKNRELYEPSLEKGEIDVVPEYAATITEFLNAKVNGAEKAQNAPLASGDTAATVAALEKLAEPLGLKVLPAGKAVDQNAFAVSKEFAEKNKLKTLSDLGKSKLKVKIAAGDECEVRPFCAPGLKKTYGIDVTGIDPKGVGTPQSKQAVRDGKVELVLTTTTDAVLDGLVFLEDDKKLQNADNVLPVLNAKDAGAPEIAAALGKLTDTLTTEDLAELNRKVDAERAKPTDVAKEYLESKGLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP12</accession>
    <name>A0A7K2ZP12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_031123776.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001542.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="207" mass="23122" checksum="A1844B6D6C081869" modified="2021-04-07" version="1">MAGFRSLARQVRDPLGDLALRRYSLRKCLERFAPYGHRATWDHLCARHGIDPEDRAPDPARLLGALEELEEARAIWLAYEAGFAERRRREKHEGLRRPGAFDDWHRRTWGGHGVARCADPEVHPSEPLAEVLRRLIAALGSGPGSACPVCADTGIEWRQERERGHEPWSGPVCTACGIAVPQPVLTDRTLARARLVRHRRLAAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP19</accession>
    <name>A0A7K2ZP19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001536">
        <property type="protein sequence ID" value="MYW34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6778" checksum="4E710F125534EEC7" modified="2021-04-07" version="1">ELREAADIAAGEWWQRALPEQRLLAAERAGHRTLAATAQRQGPPVRAPETRRGAVAPAPANGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP42</accession>
    <name>A0A7K2ZP42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrR</name>
        <name evidence="6" type="ORF">GT040_33945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001549">
        <property type="protein sequence ID" value="MYW34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515203.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001549.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="21044" checksum="6D20D472CEC6E410" modified="2021-04-07" version="1">MDAQHDDTGNAARPVLEAPDIARVLTRIAHEIVERAKGADDVVLLGIPTRGVFLARRLADKLEEITGRKMPVGSLDITMYRDDLRLRPARALARTDIPGEGIEGKLVVLVDDVLFSGRTIRAALDALGDIGRPRAVQLAVLVDRGHRELPIRADYVGKNLPTSLRETVKVQLAEEDGRDAVLLGVQQAAPADAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP69</accession>
    <name>A0A7K2ZP69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">GT040_33615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001541">
        <property type="protein sequence ID" value="MYW34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="19777" checksum="F2C426C1CB84CDA2" modified="2021-04-07" version="1">MRNRPIPGSSGLVREMSLLGDPLLHRACEDVTDFGPSLARLVEDMFATMYAAQGVGLAANQIGVPLKVFVYDCPDDDDVRHLGHVVNPELVEADGLTVRGPEGCLSLPGLEAGTERFDHAVVEGFTMTGEPVRIAGTGWFARCLQHECDHLEGRVYTDRLAGLRRSRALRAARRAPWARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPG8</accession>
    <name>A0A7K2ZPG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_34470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="WWKE01001584">
        <property type="protein sequence ID" value="MYW34243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018516091.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001584.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="369"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW34243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="477" mass="51946" checksum="06619195A07208CF" modified="2021-04-07" version="1">MSAKPRIPNVLAGRYASTELAVLWSPEQKVKLERQLWLAVLRAQKDLGIEVPDEALADYERVLDQVDLASIAEREKITRHDVKARIEEFNALAGHEQVHKGMTSRDLTENVEQLQIRLSLELMRDRTVAVLARLGKLAAEYRELVIAGRSHNVAAQATTLGKRFATAADELLVAYGRLEDLLSRYPLRGIKGPVGTAQDMLDLLGGDADKLADLEQRIAGHLGFAEAFTSVGQVYPRSLDYDVVTALVQLAAAPSSVAKTIRLMAGHELVTEGFKPGQVGSSAMPHKMNTRSCERVNGLMVILRGYASMTGELAGDQWNEGDVSCSVVRRVALPDAFFAFDGLLETFLTVLDEFGAFPAVVARELDRYLPFLATTKVLMGAVRAGVGREVAHEAIKENAVASALAMREQGAERNELLDKLAADERIPLDRAELDALMADKLSFTGAAGDQVTVLVSRIEEITKQHPQAAAYAPGSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPJ9</accession>
    <name>A0A7K2ZPJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NfeD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_34620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001586">
        <property type="protein sequence ID" value="MYW34272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="53"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="145" mass="14780" checksum="9593B212D053EDFA" modified="2021-04-07" version="1">MPWLAWLLAAAALGVAEFFTLTLVFGLLAGAALVAAVVAGVGIGLLGQLVALALAAAAGLVLVRPVALRALANSPITREGSDALIGKRAEVVQEVTATHGLVKVSGEEWSARALDETHVIPVGALVDVMEIEGATAVVYPRELLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQE1</accession>
    <name>A0A7K2ZQE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001644">
        <property type="protein sequence ID" value="MYW34586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="109" mass="11761" checksum="A8DA2B7D4FBD80EF" modified="2021-04-07" version="1" fragment="single">MSDETPRPVAVVVGGGLAGITAALRLADAGLEVTLLEGRPRLGGLAFSFQRGDLTVDNGQHVYLRCCTGYRWFLNRIEAAHLAPLQDRLDVPVLDVGRAAGPRLGRIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQN0</accession>
    <name>A0A7K2ZQN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional o-acetylhomoserine/o-acetylserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_36590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001674">
        <property type="protein sequence ID" value="MYW34652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="453" mass="48319" checksum="7ED2614E93E89027" modified="2021-04-07" version="1">MSQPLDSVTAGHTPEDVNRQDPGAAWSFETKQIHSGAAPDPTTGARAVPIYQTSSFVFRDTQHAADVFSLAEPGNIYTRIHNPTQDVLEQRIAALEGGVAAVALASGQAAETLALLTLAGSGDHIVSSPSLYGGTYNLFRHTLPRFGIEVTFVDDPEDLDAWQAAVRPNTKAFFAETLGNPRGDVLDIRAVADTAHAAGVPLIVDNTVPTPFLLRPIEHGADIVIHSATKFLGGHGTTIGGVVVDAGTFDFGAHAERFPEFHEPDPSYHGLQYWPALGPGAFAIKLRVQLLRDLGPALSPHSAFLLLQGVETLSLRLERHTSNALELARWLEQRDEVEAVHYAGLPSSRWYEAGQRYLPRGAGAVLAFELKGGAGAGKRFVDAVELFSHLANIGDVRSLIIHPASTTHSQLTEEQLVATGATPGLVRLSVGLENVDDLKADLEAGFRAAKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQQ6</accession>
    <name>A0A7K2ZQQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-IIA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001678">
        <property type="protein sequence ID" value="MYW34682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041065">
        <property type="entry name" value="GNAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18407">
        <property type="entry name" value="GNAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GNAT_like" evidence="1">
        <location>
            <begin position="293"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="347" mass="35657" checksum="F7BC1DB5A0A96220" modified="2021-04-07" version="1">MSQQHDRYRPAGSSTALSAAYDTALLDLDGVVYAGGEAIVHAVESLSTARDGGMHLAYVTNNALRTPDAVAEHLTELGVPAEAADVITSAQAVARLMADQLPAGSRVLVVGGEGLRVALRERGLVPVESADDDPVAVVQGYGGPDLAWGRFAEASYAVARGLPWYASNTDLTIPGARGIAPGNGAAVEVVRIATGAEPQVAGKPLPPMHRETVLRTGAERPLVVGDRLDTDIEGAFNGGVDSLLVLTGVTDAAQLLAAPPQHRPTYVDRDLRGLLTGQPEVTGEGGSDDVFRCGGWTAAVRDGKDLVLEGEGDPLDGLRALCGAAWTFAGGGAFGLDTEKAVAALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR14</accession>
    <name>A0A7K2ZR14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001686">
        <property type="protein sequence ID" value="MYW34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="16229" checksum="C0437B43D0E1D472" modified="2021-04-07" version="1">ARHPEPALLDPRTRTALRTGTRLGGRVVRAARAREVRQHRRIGALFDASGYDVLLTPTTAAPPPRIGTFDRLSAWRTDVTMAAACPYAWPWNVLGWPGINVPAGFTRSGLPVGAQLLGPSRSEERLIALAAQLEDDLRWYERRPPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR29</accession>
    <name>A0A7K2ZR29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_37470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001694">
        <property type="protein sequence ID" value="MYW34821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029717367" evidence="6">
        <location>
            <begin position="48"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="44"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="212" mass="21843" checksum="CB89D8AB305B8FDF" modified="2021-04-07" version="1" fragment="single">MSTDTPPRRSRFRWIPLRSGRSKVIAGLTALAVPFAAMVGLATPAAAATSATATYTKKSDWGSGFEGQWTVKNTGTTALSSWTIEWDYPAGTRVNSAWDATVTNSGNRWTAKNLGWNGNIAPGASLSFGFNGSGPGAPSGCKLNGASCDGSTVPGDNPPSAPGTPTTSDVTNTSVKLSWSAATDDKGVKNYDVLRNGAKIATVTGTTYTNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR33</accession>
    <name>A0A7K2ZR33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FtsW/RodA/SpoVE family cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_37150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001684">
        <property type="protein sequence ID" value="MYW34757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="469" mass="50177" checksum="7F04938A5B296A71" modified="2021-04-07" version="1">MSVVTNTTTIGAIDAPSRRNTELMMLVFAIAISVFAYANVGLALDGSLPSGMFGYGAGLILLGGVAHLVVRKFAPYADPLLLPLATLLNGLGLVLIWRLDQSPRLIQRAEQAYGAYSPDAPKQLLYSAIGVAFFVAVLMILKDHRILQRYTYISMVAALILLILPMFFPAVNGAKIWISLGPFSIQPGEFAKILIAIFFSGYLMVKRDALALASRRFMGIYLPRGRDLGPIITIWALSILILVFETDLGTSLLFFGMFVVMLYVATERTSWIVFGLLMSAVGAVGVASFESHVQQRVSAWLDPFSPETWAQSDQLGQSLMAFASGGTLGTGLGQGHSDLIMFAANADFILSTVGEELGLAGMMAVLLVYALIVERGVRTSLAARDPFGKLLAIGLSGAFAIQIFVVAGGVMGLIPLSGMTMPFLAYGGSSVLANWALIAILIRISDTARRPAPTPSPSTDAEMTQVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR98</accession>
    <name>A0A7K2ZR98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="MYW34865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="38"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="262" mass="28760" checksum="7D409E1EEF436BDF" modified="2021-04-07" version="1">MSEPPAVPAPAPIPVEQLHFAMPPVHASPDEERTYRRQRLAGALRLFGEYGYEDGVSGHITVRDPELADCYWVNPFGAPFADIAPQDLILVNGDGQVVQGRFHVNQAAFAVHAAVHRARPGAVAVAHTHSTHGRALAALGELIEPITQEACAFYEDHALFDTYTGVVVDEEEGRRIAEALGPRKAVILLNHGLLTVGDSVDAAAWWFLTMERACRVQLLARAAGKPVLIDHRDAVTTREQLGSDLVAWINYQPLWQRIARTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRC0</accession>
    <name>A0A7K2ZRC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001729">
        <property type="protein sequence ID" value="MYW34940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWKE01001729.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="245" mass="26906" checksum="5A54359CD38E8FA9" modified="2021-04-07" version="1">MIGLVLAAGAGRRLRPYTDTLPKALVPVDGDKTVLDLTLANFAEVGLTEVAIVVGYRKEAVYARKAELEATYGVTLTLIDNDKAEEWNNAYSLWCARDVIKRGVILANGDTVHPVSVEKTLLDARGKGQKIILALDTEKSLADEEMKVITEEGKGVQRITKLMDPATATGEYIGVTLIEAEAAEELADALKTTFERDPDLYYEDGYQELVNRGFTVDVAPIGTVTWVEIDNHDDLKKGREIACQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRF2</accession>
    <name>A0A7K2ZRF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XdhC/CoxI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001724">
        <property type="protein sequence ID" value="MYW34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="2">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="2">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="17089" checksum="25567BDA6D9CC75D" modified="2021-04-07" version="1" fragment="single">MLDIAEELHRWVSQGRAFAVATVVAVGGSAPRQPGAALAVDADGTAIGSVSGGCVEGAVYELCQQALEDGRSVRERFGYSDEDAFAVGLTCGGVIDILVTPVRADDPARPVFAAALAASAEGTAAALARVTEGPEELLGSPLLVRPDGSYEGGLGGHPALDRTAAAETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRT5</accession>
    <name>A0A7K2ZRT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper homeostasis protein CutC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001730">
        <property type="protein sequence ID" value="MYW34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="24150" checksum="8FA46F1E63920062" modified="2021-04-07" version="1">MSNRAVLEVIALDAEDAVAAQAGGADRLELVTDMAADGLTPSRETFAAIRSAVDIPLRVMLRVADGFAAGDIDVLVGKAREMRRAGADEYVLGFLDEDGHADLVAVERIVAELDGARWTYHRAIDRAADRDALRKQLADLPGLDTYLTAGSPTGVDDGIPTLLAEAARTGQPGYEPQILVGGGLQLHHLPQLRAAGIDAFHIGGAARPSGWSAPVDAAAVREWREALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS07</accession>
    <name>A0A7K2ZS07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replicative DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001743">
        <property type="protein sequence ID" value="MYW35009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="2">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="234" mass="25446" checksum="B5E41CBBC35C6F58" modified="2021-04-07" version="1" fragment="single">MTADMWQTPVEDMAPDAMPGGPSVFEDERIIAASVMARPDLIDELGGEFDPADIQDDRYRWVWNAVDEIRQNLTDDEIRWQAVNRQLQAWKAVGYMPIVPLALDQLARLYDEARPNYSAAAWHAQQITKASVARRCLALSADMKVRAQSAGFDPDIDIAAAQDALDSLTRQDGASTPSLVGDLIGAALERAITPPTNENRIPTGFMDLDALLTGGFAPGQLVVIAARPAIGKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS26</accession>
    <name>A0A7K2ZS26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_39370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001785">
        <property type="protein sequence ID" value="MYW35180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW35180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="36321" checksum="F23109BBAC706D5F" modified="2021-04-07" version="1">MTSDDFLSDRTTGGTADAETVIAADGVRRSYKDGFEAVSGVSFSVARGELFALLGTNGAGKTSTVELLEGLALPTAGTIEVLGHDPYRERAAVRPRTGVMLQEGGFPSDLTVMETARMWSACTTGARPAAEALEMVGLTSRTGVRVKQLSGGEKRRLDLALALTSRPEVLFLDEPTTGLDAEGRRDTWDLIRALRDGGTTVLLTTHYLEEAEALADRLAIMHQGQIVTAGTTAEVTASQPARIRFTLPDGVPAGHLPLSLRAAAEGQRIEIRTSGLQESLHELLGWARESGVQLLGLDARSASLEEAFLQIANTQLRSRADDPRRAGTRPTDDTKKKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSG4</accession>
    <name>A0A7K2ZSG4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_40070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001832">
        <property type="protein sequence ID" value="MYW35306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="65"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW35306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="301" mass="33558" checksum="993A1CDF02B7AA25" modified="2021-04-07" version="1">MGETDVTAQEDGKTGWSDRLRSLRSPGRPRLWFEILLIAVSYWLYSLVRNAVPEQKAQALSNADWIWSAEKALGLAFEETVNHAFNSVTWLIVSMNYYYATLHFVVTIGVLVWLFRRHPGRYAATRLVLFATTGVALLGYYLYPLAPPRLMNGTNFIDTVLVHETWGSMASGNFKNMSNQYAAMPSMHIGWSLWCGLTIFALASAPWARILGLLYPTLTLVVIVATANHFWLDAVGGMACLAFGYAVSRAWYGSLPQHLPKWVPSKSKRGARLTGVRAAARLPRPAEKPEPEPETAGARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSR0</accession>
    <name>A0A7K2ZSR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001841">
        <property type="protein sequence ID" value="MYW35385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="262" mass="29937" checksum="AA9EF5C418EF10E3" modified="2021-04-07" version="1">MLSARSLFQEILDDDEAYRLFCSIAASGESQGGWENARIAALVPESRRSLAPRIVRHGADEDKHGRIFNALLKKRGLRPADVSPETDYTMLLEQQGIGLAHSRLRGEERLTERDIITYLAHSRITEQRASEQMRLLRRYFADHPDIGRAVRMISDDEDNHLAYCHEELLRLAREGHGRTIQRIMRECALAEIRVYRDVSLAVMDHMGRLLGWPRPKAVALAAGIHAVYAYERLTGWRRMVSLEMPERRDALGGRAVPEPEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZT55</accession>
    <name>A0A7K2ZT55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_40515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001842">
        <property type="protein sequence ID" value="MYW35389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="5">
        <location>
            <begin position="481"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW35389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="708" mass="77468" checksum="4F96417A8D35E184" modified="2021-04-07" version="1">MTAETSVPSTAMLTAAGGDRDSSNYTARHLLVLEGLEAVRKRPGMYIGSTDSRGLMHCLWEIIDNSVDEALGGHCDHIEVILHDDSSVEVRDNGRGIPVDVEPKTGLSGIEVVMTKLHAGGKFGGGSYAASGGLHGVGASVVNALSARLDVEVDRNSATHSISFRRGVPGMFTEQGPDSPFDPANGLRKGKRVPKTRTGTRVRYWADRQIFLKDAKLNLETLYQRARQTAFLVPGLTIVVRDERGTDGEGKTEETFRFDGGISEFCEYLAQDKAVCDVQRLTGTGTFKETVPVLDDRGHMTATEVTRELGVDIALRWGTGYDTTVRSFVNIIATPKGGTHVSGFERSLTKTVNEALRSAKMLRVAEDDVVKDDALEGLTAVVTVRLAEPQFEGQTKEVLGTSAANRIVAAVVAKELKAFLTSTKRDAKAQARAVLEKAVAAARTRIAARQHKDAQRRKTALESSSLPAKLADCRSDDVERSELFIVEGDSALGTAKLARNSEFQALLPIRGKILNVQKSSVSDMLKNAECGAIIQVIGAGSGRTFDIDAARYGKVIMMTDADVDGSHIRTLLLTLFQRYMRPMVEAGRVFAAVPPLHRIELVQPKKGQDKYVYTYSDNELRQTLLEFQRKNVRIKESIQRYKGLGEMDADQLAETTMDPRHRTLRRINIGDLESSEQVFDLLMGNEVAPRKEFITSSAATLDRSRIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZT85</accession>
    <name>A0A7K2ZT85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 1 glutamine amidotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001848">
        <property type="protein sequence ID" value="MYW35419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="28"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="24012" checksum="A33863BA11369D6E" modified="2021-04-07" version="1">MAKILFVVTGADHWTLADGTAHPTGFWAEEAVAPYQVFTGAGHEVVVATPGGVVPTVDRGSLAPDVNGGQEGADKVAAGLEAFEELRRPVALENVDLDAYDAVFYPGGHGPMEDLAVDPASGRLLIETLASGKPLGVVCHAPAALLAATGPDGTNAFAGYRLTGFTNAEETQAGLADKAKWLLQDRLVALGADFQEGEPWAPFVITDRNLVTGQNPASSTPLAEELLKRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5T2</accession>
    <name>A0A7K2Z5T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_00020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="94"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW27697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="431" mass="45035" checksum="74C9972031BA5F5F" modified="2021-04-07" version="1">MAVQTIAGNATTTSVDLGPAVALSCRECGERFELGPLFACASCFGPLEVAYDLPTGSPEELRERIEAGPNNIWRYAPLLPVPADVAEKPNINPGFTKLVKADNLARELGVTGGLYVKDDSGNPTHSFKDRVVAIAVEAARAFGFTTLSCSSTGNLAGAVGAAAARAGLRSCVFIPHDLEQGKVVMAAVYGGELVGIEGNYDDVNRFCSELIGDPLGEGWGFVNVNLRPYYGEGSKTLAYEICEQLGWRLPDQIVIPIASGSQLTKIDKGFQELIKLGLVEDKPYKIFGAQAEGCSPVSAAFKAGHDVVRPQKPNTIAKSLAIGNPADGPYVLDIARRTGGAVEDVNDEQVVDAIKLLARTEGIFGETAGGVTLGVTRKLIEAGVIDPALTTVVLNTGDGLKTLDAVSATSQATATIKPSLDAFRAAGLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5V7</accession>
    <name>A0A7K2Z5V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000003">
        <property type="protein sequence ID" value="MYW27730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073776302.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000003.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="73" mass="7572" checksum="DA7AD5ABE6EC242B" modified="2021-04-07" version="1">MGDLPHTHSPFGPFKIGPEGGVVLSPPSVTSSTGSGEYAATAVGEPRFGRGRRRHGLGNRLECAGSLPHYRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z671</accession>
    <name>A0A7K2Z671_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH family NRPS accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000017">
        <property type="protein sequence ID" value="MYW27803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7633" checksum="F5D276DAE315B517" modified="2021-04-07" version="1">MTNPFDDPRTQHRVLVNDEGQHALWPSFASVPAGWDEAFGPAEHAACLEYVEVNWTDITPRSARVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z674</accession>
    <name>A0A7K2Z674_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4097 family beta strand repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000020">
        <property type="protein sequence ID" value="MYW27822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="28810" checksum="979409EF410F2ACA" modified="2021-04-07" version="1">MPSFDTSEPIAVTAHVEAGSIQFTASDGPATVVDVRPRDPKRDQDVRTAGQTGVTYAGGTLTVRTPKPGLLGRTGTVDVTVGLPAGSHAEVTGAWLQVLGEGRLGEVRVKTSSGDVRLDTTGPLKLTASHGSITVDRVEGAAEITTSSGSVRVGRVDGPAVLKNSHGTTSVETARGDLRVSGANGDILIARAEGSVTATAANGTLRVAEVSCGTVQLETSYGAIEVGVREGTAAWLDVSSDSGQVRNTLTASKAPEESADTVKIRARTRFGNIDVRRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6H5</accession>
    <name>A0A7K2Z6H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIM zinc finger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000058">
        <property type="protein sequence ID" value="MYW27945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="212" mass="22408" checksum="5A3C95E66CB3AE0A" modified="2021-04-07" version="1">LQRVLRHATALRVYGPPVADGAPVASAWEVVLPGMRLTLTLSPDASRGFSGEGGVLAALATDEAAADAELVSVLLAWESAIEPATLAERSGLSVERVRAALTRLGTAGRVGYDLADAAYFHRELPYDADRAERHNPRLVAARELAGAGAVSLDGTVAYVASGDRRYQVREGDGALTCTCRWWADYRGKRGPCKHALAVTMVRRGATVAGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z762</accession>
    <name>A0A7K2Z762_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Alpha-amylase</fullName>
            <ecNumber evidence="4 9">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_02445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="WWKE01000107">
        <property type="protein sequence ID" value="MYW28158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029914070" description="Alpha-amylase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="12">
        <location>
            <begin position="475"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW28158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="577" mass="61066" checksum="83B344CA2F7259E8" modified="2021-04-07" version="1">MARRPLSAALALVAGAAAALVIPTGFGTASPAQAAAPGDKDVTAVLFEWKFASIAKACTDTLGPAGYGYVQVSPPQEHIQGSQWWTSYQPVSYKIAGRLGDRAAFSAMVNTCHSAGVKVIADSVINHMAAGNGTGTGGTSYTKYDYPGLYSGSDLDDCRAQITNYNDRANVQNCELVGLADLDTGEEYVRGRIAGYLNDLLSLGVDGFRIDAAKHMPAADLANIKTRLTNPNVYWKHEAIYGADEAVSPSEYLGSGDVQEFRYGRSLKQVFLNENLAHLKNFGEGWGFMESGKSAVFVDNHDTERGGDTLNYKNGSAYTLANVFMLAWPYGSPDVHSGYEFSNHDAGPPNGGQVNACYADGWKCQHDWREISSMVGFRNAARGQAVTNWWDNGGDQIAFGRGNKAYVAINHESSSLTRTFQTSLPAGDYCDVQSGRGVAVNGSGQFTATLGAGTAVALHANARTCSGGGSNPDPGPGTGQSGASFGVNATTQLGQNIYVTGDQAALGNWNPANALKLDPAAYPVWKLDVNLPAGTSFAYKYVRKDGQGNVTWESGANRTATVPSSGKVTLTADVWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z777</accession>
    <name>A0A7K2Z777_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000115">
        <property type="protein sequence ID" value="MYW28207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026242033.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000115.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="166" mass="17908" checksum="CE784B5F138CEBAD" modified="2021-04-07" version="1">MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQGVFLRYDLYGGRGPAMIIGNLPAGSPARETEDGQVPFEVAQLLLALENDEPIEVVSSEDVPVMQGDNLLIVRRVKLSESRIACVQFDRSDGVLVTIASWDRPITDDLYTLLKPLPAELFQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Q6</accession>
    <name>A0A7K2Z7Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000152">
        <property type="protein sequence ID" value="MYW28390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="32323" checksum="B0F7D673DDF38D96" modified="2021-04-07" version="1">MSDHDAEHPDAWTEPSAYAGDSAHPQAAGPAGPQAVTPADAADAARLVSFGLQPKLLPARDAEYADLLRRYREESAFARLADAVATGLGLIVLEVSPRAGMAVTAGEDSVFAVRMGDYARRASSDAADRFLHGLAHLAVAALAFPRPEDLADDAYIGRITVNGVDAFVRQACKRLEERAEEQGDNTDPATDTPGLESGWRVYARRSSTGATKDARRLAGSTTGIIGKAVAFLTDSGFLQRTGDDAGGAYRTTARYQLQVRDMAGSAAMAELLELGVVPVTDGTATLLPPSDPDDLELAADAGLPFHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Z0</accession>
    <name>A0A7K2Z7Z0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000160">
        <property type="protein sequence ID" value="MYW28425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19352">
        <property type="entry name" value="TetR_C_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23303" checksum="1FAC5FB82706677E" modified="2021-04-07" version="1">MTGQVRTVDGRVAGRRGQATRQKLLDCLSEMLSSSPYRDVKVIDVARKAGTSPATFYQYFPDVEGAVLEIAEEVAKEGAGLTELVAGRPWVGKAGWQTAEELVEGFLDFWRRNDAILRVIDLGAAEGDKRFYKIRMKILNSVTNSLTDSVKELQAKGKVDKDVSAAAMAGSLVAMLAAVASHQKGFTTWGVKQAELRPNLALLVHLGITGKKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8C2</accession>
    <name>A0A7K2Z8C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000209">
        <property type="protein sequence ID" value="MYW28596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="20214" checksum="A0889907F602F6FC" modified="2021-04-07" version="1" fragment="single">MSRVADHAGAAPAPPPLRRNRDFLLLWSGSAVAIIGSTASTVAYPLLVLAVTGSPSAAGVVGFVVLLPALIFQLPAGVLVDSWNRKRVMMWCDGLRAVGAASVVLALLLGELRLAHVMVVGFVEGTLTVLNGLASTAAVPNVVHPSQLSAALAGNEARGRAATMIGTPLGGILFGVGRAVPFVLETFAYLVSLATLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8F2</accession>
    <name>A0A7K2Z8F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000217">
        <property type="protein sequence ID" value="MYW28634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="466" mass="51101" checksum="0A6F0283D90F6358" modified="2021-04-07" version="1">MPLRRVHDLYRSHVNKSQVSLMTSFGFGRELVSHAEGSWIHTRDGRRILDFTGGVGVLNHGHNHPRILAARRRFQEQRRMEVHKTYFSPYIAALGHNLAQLLPGDLDMSFFPNSGAEAVEGAVKLAYKYHGGKRQRILHADISFHGKLLGSGSLTGSAQTTFAFPGIPGVSAFRYGDLDSVRESVAAARNAKGRCDVYAILIEPFSASTMTECSEEFLRGLRELCTAEDIVLIFDEIYTGWGKTGSLFHFMRYPGLVPDVVTTSKSFGGGKSSISAFVAREPVFRQAYDSLGDAMLQSTSTTYYGFGEETATALEAVNIAVEDDYPARARAIERVLAPGLERLRKQYPDIIADVRGAGALYGVFLDGGPKMLDLAAKIAPGGLARDPLLRTKVITCAVVNAMYQEHNVYMYYTLNGRSPLVAAPSLVAGAEEVEIFLDAFDKTLARGMNRLLAAFLKDKAVSRWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8H3</accession>
    <name>A0A7K2Z8H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_04905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000214">
        <property type="protein sequence ID" value="MYW28623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029712814" evidence="3">
        <location>
            <begin position="48"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="4">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="28350" checksum="AF840379C0E8E218" modified="2021-04-07" version="1">MRLEPRRKNRLSLRSRNLRATGAAACLAAAALLLTSCGQSSDSATSAATEAAKVLPQRTTASPSATADLTEDQQERKSVLDATKVTFDDAATTAVGEVAGGKLVDLDLEGVDDDDRDESPSPTGSPTGSPSPTGSPSPTGSPTATGSPSASPGADGPVWVAEVAEKDGTVHTVRINAVDGKVIEARVDADQDAEDRKQTADRLAQATQTPEQAAKVATEKKKGTVTSVSLDEADGNDGNSVVWSVDVVGSDWKKTTFDVDAKNDTIVREESDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8N3</accession>
    <name>A0A7K2Z8N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_05340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000246">
        <property type="protein sequence ID" value="MYW28706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15520" checksum="75E19A4873F460F9" modified="2021-04-07" version="1">PARPAPVEFSPGDLPALRSAGVRYLREEPAVPVRITGAVVRLRRSGPRGAGIVRLRVLAGAEVAHVRVELDEEAYRIAGHAHLVGLPLRVEGRLERRGGFRRLTGASQVAPVQVDEAERDRLMKSLQENVDFFEEACAGEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Y9</accession>
    <name>A0A7K2Z8Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-3-oxopropionate reductase</fullName>
            <ecNumber evidence="4">1.1.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_05875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.60" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000256">
        <property type="protein sequence ID" value="MYW28811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006398">
        <property type="entry name" value="Tartro_sem_red"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01505">
        <property type="entry name" value="tartro_sem_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="169"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="297" mass="30297" checksum="652694AE64DE81AB" modified="2021-04-07" version="1">MSNNLPKVAWIGLGIMGSPMSENLIKAGYAVTGYTLEQDKIDRLVAAGGTGASSIADAVKDADVVITMVPASPQVEAIAYGPEGILENAKRGALLVDMSSITPQTSVDLAEKAAEKGIRVLDAPVSGGEAGAIEAVLSIMVGGEQADFDAAKPLLEALGKTIVLCGPHGSGQTVKAANQLIVAVNIQACAEAVVFLEKSGVDLAAALDVLNGGLAGSTVLTRKKDNFLKRDFAPGFRIDLHHKDMGIVTDAARNVGAALPVGGVVAQLVASLRAQGDGGLDHSALLRSVERLSGSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z968</accession>
    <name>A0A7K2Z968_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000297">
        <property type="protein sequence ID" value="MYW28910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="10020" checksum="93AE4D7D918D10BF" modified="2021-04-07" version="1">ERDTHPDTIRHTLTNDLPQPLRHPAKLLKHRLTVLLPPPLPGADDLAAPARPRIAVTPFQTCDGCERAFRAPTPGHCRDCRNAHSPAQAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9B4</accession>
    <name>A0A7K2Z9B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_06430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000298">
        <property type="protein sequence ID" value="MYW28918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="21421" checksum="4CEDA9BA8EA8B150" modified="2021-04-07" version="1">MSRSSTYHHGDLRAACLRAARELLEEDGSAGLSLRAVARRAGVSATAPYRHYADREALVSAVAAEGYRELAGSLAQAHPAPSTPDELAAVAVAYVRFALEHPALFRAMFAEPCDPTSAERVAATEAISQYVRTIVGATFPDADAGALSTTVWALVHGLAFLHLDGKLDTSTPEAVAVQVNSAVHALFNVSPAMSRTAAAAAAQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9P5</accession>
    <name>A0A7K2Z9P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000320">
        <property type="protein sequence ID" value="MYW29054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12646" checksum="16A2C9A3F77BB5E7" modified="2021-04-07" version="1">MRQDAVRGHLDGLLLAVLEPAPLHGYAIITAVQQRSGGALELRTGTIYPALNRLERLGLLRSTWESEGGRKRRCYALTEAGARFLADERSAWQDFTAAIGSVLAPVAPHPHPHGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9S1</accession>
    <name>A0A7K2Z9S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000330">
        <property type="protein sequence ID" value="MYW29083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="835" mass="88553" checksum="6061FAB83BEBE6EF" modified="2021-04-07" version="1">AYELWAGRRRTPHSDCEACEICERALYRVAAGDDERALEVWAPVLAGKESCQEEPARSVSHALLPLLRTGHAGRARELHLAGYRACRRNPSMAGEVGRHLEFCALTGNEARGLELLAENRNLFDEVDSPLDQLDFLTGVEVLLRRVEGLGHGELPVAGYAGRAWTVAGLCAEVRGRGDGLAARFDTRNGTSAQSGRRTARLDRAPLLDALELALRTRVLDDLAPGDAPGDRREAVAASVSRAASAVPEELPELIRRARELDEEGHPDARACWARLRVLVAARDYSHPEDPAVGPYGRLCADLLSDEAYRAAERGDYASAVDLHEEAAGLYEDAGAADDVVLARACALLAAAEVAGEGGEDGEDEAELKAAGLADAHAAVVRLQEEATGLAPYVEGRLLRLRASALGVRLQSSGDQAHAAVVFAEADLLQEFATRHGLTTQVSGAMLLRAGTHALSGDLPAAVTEIDALRDRLVSDGPAWHLPRALGLRGRLQLGLRDAAAAHADLAEGLRLAAAWPADAVDTSRLHADLAQTCLHLGRPDEALTHLTRSAEVDLRDGKRVDAFCTYSNAAQLCLDLGRIEDSIALLDSLLGEPDVTGGELDDRLVAQLRLLRARALHAGDDLKAATAEFAALAAESAGWDDDPGSHAMIAAETAMILAEAGEFDRAGEVADRALAAHVLSPRYELISNCLRELARLRAQRQGPDGLTAALAHLDEAGRVADAARAAGFQPVGRSLETALAYEHGRVHAYVGAYEDALAALEKALALLGEPGAEEGAAGEWAECVRLAGAVEGIYLERPAPALVRLDAAVARLTALGHLEECEPLASLAAQLRDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Y0</accession>
    <name>A0A7K2Z9Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="34155" checksum="05E107A610550C0B" modified="2021-04-07" version="1" fragment="single">MRGEADFGPTARALTTMDASNYRRVPLGVLAPRDADDIAAALTVCQEFGVAVVPRGGGTSIAGQATGTGLVLDLTRHLRSILDLDPAARTATVQPGVILDELRAAAAPHGLTFGPDPSTHSRCTLGGMIGNNSCGSHSVAWGTTADNVRALEVVRYGGEALRLEQGAPQQGRGADLPGVRELIDAHLALLRTGYPDLPRRISGYALDALLPEHPGGPDPVRAFCGSEGTLAVVTEATVRLVEAPRARALAVLGYADESAAAEAAPGLLPYRPLTVEGMAADLVREPAGPLPRGAAWLFVETGGATPAEARAHAERILRAADAVDGTVVTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAA6</accession>
    <name>A0A7K2ZAA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000390">
        <property type="protein sequence ID" value="MYW29311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="12650" checksum="1407C0C769676C4D" modified="2021-04-07" version="1">MNPDKDSARGLAQLEGYLLWNAEVESARAQARRFTGELPWLTTAQREDVERVYLADRVAVSRESLTRVRDRAAELRGEYTARYERLRARCVALSVVAVGAVTGIGTSLTLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAC0</accession>
    <name>A0A7K2ZAC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000373">
        <property type="protein sequence ID" value="MYW29252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12825" checksum="1EDD5F7E7DE24D14" modified="2021-04-07" version="1">MESKFTNIRRIPDEEVSRRDIRYLALVRVDLIALSRRWGRPDVGEDSLAEWLSYTFALPTGEKFTLQREAFSPPTLGFLLSVTRTLFSAEAAGQVIKALDIPEAVAIEVSPEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAG5</accession>
    <name>A0A7K2ZAG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="16"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="14200" checksum="DDC570F2267B37DA" modified="2021-04-07" version="1">MNATNASTSEPADTITGLGVVIGSTDPDALIAWYRAALEPLGARWAEHLLMVGPGAIIGFDRRDDVADRAAEPGRHLINLTVRDIRAAERHLDSLGVTWVRPVEEVGGGWFFSTVVDPVGNYLQILQGPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAJ3</accession>
    <name>A0A7K2ZAJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000404">
        <property type="protein sequence ID" value="MYW29364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="21089" checksum="C18327A066CE46AE" modified="2021-04-07" version="1" fragment="single">MSETPTNTMQYRFDGPEDAPVLVIGPSLGTTWHMWDRQIPELAQHWRIFRYDLPGHGGAPAHAAPSVAELSDRLIATLDGLGVQRFGYAGCSIGGAVGADLALRHPHRVASLALVASSPRFGTADEFRQRGVIVRSNGLEPMARTAPERWFTPGFAAAQPAIVEWAVQMVRTTDPGCYIAACEALAAFDIRDHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBA0</accession>
    <name>A0A7K2ZBA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000467">
        <property type="protein sequence ID" value="MYW29640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030563432.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000467.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="119" mass="12409" checksum="F80CC94877E244CF" modified="2021-04-07" version="1">MAGEPQTDCLFCKIVSGDIPATIVRESDTTVAFRDINPQAPTHVLVIPKVHYPDAASLAAAEPQIAADVLREAGAVAADEKVDSTGYRIILNTGSGAGQTVFHAHAHVLGGRGLQWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBI2</accession>
    <name>A0A7K2ZBI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_10625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="118"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="28807" checksum="31C4E2D36DB655AC" modified="2021-04-07" version="1">MGPKTQRVYETIRSWIETGRYAPGDKLPSERTLSTELDIGRTALRQVLARLANERFIKAHDRSAYRVAGGTGVPTPSDLPAWRIGGSRRIYENRWVNLDLVDVEPPGVERFEHHVVRLHHVAITAVVDDQNRVLMLWRYRFVPEQWGWELPGGIVDAGEDPAATAARETEEETGWRPAKVEHVVTYQPMIGMVDSPHEVFVARGATQVGEPTDTEEAGHVAWVPLDEIPRLMSEGKLMGSGTIVALLHLLSSRPTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBK3</accession>
    <name>A0A7K2ZBK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_10285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000469">
        <property type="protein sequence ID" value="MYW29655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="50"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="34842" checksum="3F6B7712BC42C44D" modified="2021-04-07" version="1">MPHATALPATGHRPRWWTELPLIAVVYGLYSMGRLLVRGDVSTAVDNGLAILRFEQAFHLNAEHPLNRLFTSTPSIGIPADFAYASLHYLVTPAVLIWMFRRRSAAYRAARVWLMNSTLLGLIGFTLVPTCPPRLLDASHGFVDTMAQYSAYGWWGAGASAPRGLSGMTNQYAAMPSLHVGWSLWCGILLWRHARHPLLRAAGVAYPLVTTVIVMGTANHYFLDAVAGCAVMGLGALLTRPVMRLADRVKGRLGTAFATVRTASEPVKSPIVSPGCKTSAGERIPGQRTSSADSPDAAADSAGPGRATGAGPGATTGASADDDAPAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBK8</accession>
    <name>A0A7K2ZBK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_10760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000491">
        <property type="protein sequence ID" value="MYW29747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="339" mass="36849" checksum="0E48AC982126A39B" modified="2021-04-07" version="1">MRDDQEMGRITLAQVAQQAGVSISTVSKVLNGRQDVAAPTRVKVERLLEAHAYRRTTRSAGEAPLIEIVFHELESIWAMELIRGVENIAKAHNAGVVLTESGTRHAPGPEWMEAMLQRRPLGVVLVFSTLPGEVKQQLRARSIPFVIVDPAGDPDPDVPSVGSANWNGGLAATRHLIECGHRRIGVITGPEDMLCSRARLDGYRSAMTMAGLEVDPGLVLFGDFHVEGGYDRATEMLSHPERPTAIFAGSDLQALGVLEAARVHGLRVPHDLSVVGYDDVSIARWASPALTTVHQPLRQMAEEATQMLMRLRAQEPVSTRLELATTLVVRKSTAPPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBM7</accession>
    <name>A0A7K2ZBM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000491">
        <property type="protein sequence ID" value="MYW29739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026242257.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000491.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16495" checksum="6B6C2268490E6C6D" modified="2021-04-07" version="1">MEDDRSPTFAQLLDHLFREVHPPSRGPYTYAEVAEGIRKAATGEGRGVTASAIQQLRTGAKRNPTRHTIKALADFFGVPAGYFVDSEAAERTKAEIGLLAAMRDQDVRKVALRANGLSVDSLKMLSTVIEQARRLEGLTTDDGPQDLNLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC61</accession>
    <name>A0A7K2ZC61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_11670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000545">
        <property type="protein sequence ID" value="MYW29923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="UCP036654"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="PTHR43260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="550" mass="59325" checksum="E8F8E77A568386B6" modified="2021-04-07" version="1">MAYDADVIVIGAGLAGLVATAELVDAGRSVIVLDQEPEQSIGGQAHWSFGGLFLVDSPEQRRLRVKDSRELALQDWYGTAGFDRKEDHWPKKWAEAYVDFAAGEKRSWLHQQGLRIFPVVGWAERGGYDATGHGNSVPRFHITWGTGPGVVAPFERRVREGVAKGLVQLRFRHRVTGLARTAGALDTVTGEILEPSAAERGTASSREATGTFELRAQAVIVTSGGIGGNHDLVRSQWPERLGTPPEKLLSGVPAHVDGLMLGIAEEAGAHHINRDRMWHYTEGIENWNPIWSKHAIRILPGPSSLWLDARGKRLPVPLFPGFDTLGTLEHIMRSGHGYTWFVLNQRIIGKEFALSGSEQNPDLTGRSVRDVIGRARADVPAPVKAFMDHGADFVVEKDLDALVRGMNAVSGDGLIDAAELRREITARDREIANPFTKDLQVTAIHGARAYLGDRLIRTAKPHRILDPAAGPLIAVRLNILTRKSLGGLETDLSSQVLTADGTPLPGLYAAGEAAGFGGGGVHGYRSLEGTFLGGCIFSGRAAGRAAAKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCC3</accession>
    <name>A0A7K2ZCC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small hydrophilic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000547">
        <property type="protein sequence ID" value="MYW29962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030565531.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000547.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045961">
        <property type="entry name" value="DUF6381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19908">
        <property type="entry name" value="DUF6381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="63" mass="7163" checksum="E596B8F37E324F6F" modified="2021-04-07" version="1">MSGSDEPADLARQMREKAQQLAEAAERATDPEERQRLEKKSRTIRDRSEQQSAMAAGDIYPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCV5</accession>
    <name>A0A7K2ZCV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acs</name>
        <name evidence="5" type="synonym">acsA</name>
        <name evidence="9" type="ORF">GT040_13040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000606">
        <property type="protein sequence ID" value="MYW30186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="104"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="546"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="207"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="402"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="426"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="665" mass="72307" checksum="45A1DE85334CA951" modified="2021-04-07" version="1">MPRDTTDTLGLGEVVSNESLANLLREERKFAPPAALAANANVTAEAYEQAEADRLGFWAEQARRLTWATEPTETLDWSNPPFAKWFADGKLNVAYNCVDRHVEAGNGDRVAIHFEGEPGDSRAITYAELKEEVSRAANALTELGVSKGDRVAVYLPMIPEAAVAMLACARIGATHSVVFGGFSADAIATRIQDADAKVVITADGGYRRGKPSALKPAVDDAVSRIESVEHVLVVRRTGQDTAWTEGRDVWWHEITARQSAEHTPEAFEAEQPLFILYTSGTTGKPKGILHTSGGYLTQAAYTHHAVFDLKPSSDVYWCTADVGWVTGHSYIVYGPLANGATQVMYEGTPDTPHQGRFWEIVQKYGVTILYTAPTAIRTFMKWGDDIPAKFDLSSLRVLGSVGEPINPEAWMWYRKNIGADKCPIVDTWWQTETGAMMISPLPGVTETKPGSAQRALPGIAATVVDDEANEVPNGGGGYLVLTEPWPSMLRTIWGDDQRFLDTYWSRFEGKYFAGDGAKKDEDGDVWLLGRVDDVMLVSGHNISTTEVESALVSHPSVAEAAVVGANDETTGQAIVAFVILRGTATTSDELVAELRNHVGTTLGPIAKPKRVLPVAELPKTRSGKIMRRLLRDVAENRELGDVTTLTDSSVMDLITTQLPSSSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDL2</accession>
    <name>A0A7K2ZDL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_14405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000670">
        <property type="protein sequence ID" value="MYW30441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="139" mass="14616" checksum="DEE646B3218D0F00" modified="2021-04-07" version="1">PEGETAAETAVAPAPVSDDPATLAALTDLESCAQRFTDLGAVWDAARARALLRTRQPARKGRPPGRPSHADQLSPREEEVAQLAVSGLTNREIAATLHLSPRTVEQHIAGAMRKTGALSRRDLAHRPGPTPPCAGKAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDT7</accession>
    <name>A0A7K2ZDT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000689">
        <property type="protein sequence ID" value="MYW30488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="26202" checksum="82B0CBEAEBF3E644" modified="2021-04-07" version="1">LDGIPSARSVLALHTQGSPVAPALLTLVADGRVRLSSGSVHHLAEPLDGLGLPVPPHTPAGRPDMADREVESLLSDGWDPSLALRIARRPEPPDPALAGELHLLRNQLDRWLAPADSSGPAALRARLLWCALRLCPAPWSADEAAVFGRYAGVVTDAFEEAVSGGGPEELAGSCWTSWTRWSRRCPPCSGSPSWSNCARSGGCSPPLRLRLCPCSGGAGPCCSAPTSTGRSPPPSWAPAPGGAHRTSCAAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDW7</accession>
    <name>A0A7K2ZDW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3159 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000715">
        <property type="protein sequence ID" value="MYW30553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010219">
        <property type="entry name" value="UCP010219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="268" mass="28975" checksum="8630CF80235796EA" modified="2021-04-07" version="1">MTSLDKLTSETDQPHPTDRQSAGGRHAAQQDAESKAVTEAALFEAFGGVRGMVETVLPGLLFVTIFTINKDLHTSAIAALAVSLALVAVRLIRRGTMKHAFSGVFGVAFGVVFAMMTGNAKDFYLPGMLYTLGLAVAYLGTAAAGVPLIGLILGPVFKENLSWRTRNPGRKKAYTKASYAWGLILLAKCAILFPLYWWADTTQFGWVLIALKIPPFLLAVYLTWVFLAKAPPPIDVFAEMEAEEKAAEQAEKDRKAEQAAAALRTPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDY2</accession>
    <name>A0A7K2ZDY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000687">
        <property type="protein sequence ID" value="MYW30485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="10966" checksum="2580BE2EF979A923" modified="2021-04-07" version="1">VGAQAVASACRAALRQAGASVTQHRGGWDRIPLPLRTSGVTPREYEVFVLLPERPGNQQIARRLSISPRTVEKHMASLLSKTGRADRSALCEFAAECAVEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDZ5</accession>
    <name>A0A7K2ZDZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_15125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000716">
        <property type="protein sequence ID" value="MYW30574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030572631.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000716.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="27811" checksum="138D58CE3E99661C" modified="2021-04-07" version="1">MARDARWDALLELVGKHGRVEVEEAAAELAVSAATIRRDLDQLAEQHLLTRTRGGAVAHGVSYELALRYKTGRHAPEKQAIGRAVSGLVAVGEVVGLTGGTTVTEVARALAVRPDIVGETTVAGGQPTLTVVTNALNIASELAIRPQIKMVVTGGVARPQSYELTGPLAVGVMNEITLDVAVLGVNAIDIERGAYVHHEGEASVNRLLAERAQRVVVAADSSKIGKRAFARVCDLGLVDVLVTDGHITAEAKDRFGEAGVQVITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE48</accession>
    <name>A0A7K2ZE48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="34"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="257" mass="27653" checksum="3B8F5D0CE0EFE255" modified="2021-04-07" version="1">MIYGAMKFSIGGSLKLAFRPWVEGLENIPERGPAILASNHLSFSDSFFLPAVLDRKVTFIAKAEYFTAPGVKGKLTAAFFKGVGQLPVDRSGARGAGEAAIKAGIQVVESGGLFGIYPEGTRSPDGRLYRGKPGGLARVALATGAPVIPVAMIDTEKIQPPGQVVPKLMRPGIRIGKPLDFSRYQGMDGDRFILRSVTDEVMYEIMKLSGQEYVDIYATAAKRQIADEAKAKAEEAKRERKQAQAADDEDGTERSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEA8</accession>
    <name>A0A7K2ZEA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_15610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000729">
        <property type="protein sequence ID" value="MYW30666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="30"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="542" mass="56022" checksum="AECB6CF37E64B30C" modified="2021-04-07" version="1">MSAPSPSASAHAPAPEPRIPGAIHRRRWWILTVLMFSLLIVVLDNSILNVAVKTIASPAPTGIGATQSELEWAINSYTLVFAGLLFTAGLLGDRIGRKKVLLFGTLVFGIGSALAALSASPGELITWRALMGFGAAFVMPATLAVLMNVFERDEQPKAIGIWAGSVGLGIAIGPITGGLLLEHFWWGSIFLVNVPVVVLALIAMAVLVPDSRDPKPGKVDPVGVALSIVGLVLLVYGIIRGGELADFTDTTVLLPIVGGLLVLAGFVWHEKRSSHPAIDITYFRKPAFSAAVAAIALVFFALMGVTFFSAFYLQSVRGYSALQSGLLIVPLAAAQMVFAPRARLVVDRFGARAVCTVGMLLVAAGLASFALFGTGTPVWVLCLVFFVQGTGMAHIMPPVTVAVMQALPREKAGSGSAINNTFRQVGGALGIAVLGSVLSTVYRGDIEGHLGAVPAGARAVAGESIEATLGVAEKLGPVAGKPLVAAANDAFISAMHVTALGSAAVALIGALVVGLYLPGRTRAGTAEPADQAPRPAEEPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEI5</accession>
    <name>A0A7K2ZEI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_15760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="369" mass="37364" checksum="61C0727AC30652C5" modified="2021-04-07" version="1" fragment="single">MGADMSGRGVIRRAVAGQRRDIVVGSLLGAAHQTGEALVPVLIGLIVDRAVVRPDGGALALWLVVLAVVYAMLSYGFRFGARAGERAAEQAAHQLRLDVVRRVLAPHGGAEAGRPPGALVNVATEDARRVGAFNMALTLGIAAVVGVVAGAVLLLRASVPLGLLVLIGAPVLMALGHYLARPLEHRSQAEQERAAHASGVAADLVAGVRVLKGLRAESAAVARYRSTSQASREANVRAARAAALQTGLMLTLTGAFIALVALVGGRLVLSGSIGLGALVSAVGLALFLPGPIAVLAWVGAELAKARASAARIADVLAAPGETTGGTTEPGPSPGELRLHGLGHAGLHGIDLIVRPGEHLGIVVTDTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZET2</accession>
    <name>A0A7K2ZET2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="109"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="292" mass="32159" checksum="85311CAE9C2B7AF1" modified="2021-04-07" version="1">MNRATPQGNRSSTVLGRRLGSELLRLRDASGKTQQQAAQVISATNSKIVKMERGWVPMRDPDIRTLCEFYGLEDEKSVGRLLEVAQVDRERRKAKGWWNQYPELRSLVEYVALEDIATGVRTWQGAFIPGLLQTPDYARALAVGNADWDDPDEIERFVEAKIARQARLVDSNPLALWAIVGEGALRQLVGGREVMGAQLARLAEAAAEPNVTVQVVPFLAGSHPGMTSAFSIVSFAEPGAMDVVYMDTTSSTLWLESETDAARHNVTFGRIARSGLAPRDSIALIGRIRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFK4</accession>
    <name>A0A7K2ZFK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="337" mass="36516" checksum="83E262E96F083349" modified="2021-04-07" version="1">MAGGPEGPGRLERLLNWIARNFELLLAVLGAITVGVMDLFGDALGDDATAAATVLVLGAIAAGSLRQRARADHLADTVDGIQRALEGMEADRLADAVDGTRRALEGMEMVRSLTGSEIGAELRTARERSDSWDFKGGTGTYLRAVTLPECVARARGNRSNLTFTIEVVDPADTRACAAYARFRRSYASTASSSDPQTWTADRTSKESYATVLAAGWHLQRLPSMTVHLCLSSTAPTLRFDVSASRLIITQDDPAQPGLLVTRNHPLYRYYSVELQQSRAQARTIELSQARALDADPTADQTRAFFESVGLPLPTSYSDGEVREIVDKALRAENPYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGG0</accession>
    <name>A0A7K2ZGG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000913">
        <property type="protein sequence ID" value="MYW31416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029838937" evidence="2">
        <location>
            <begin position="29"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="224" mass="22296" checksum="3780759CEE3182D2" modified="2021-04-07" version="1">MRTSRIAVTAAAVVAGLSLSACGGDDNATNAGNASSSSNSAPAEERTGSAPDSAEQPEGGSGAPETEAPDQGSAGQGSAGTGSKPERCHTDDLTITASDATIGGDETKTVAVKLLNKSDRACSIMGFAGVNLLSSEGAIPAARRDQTDDGTVLKSGEPTYFGIFYKANESGGSGVKIKGLVVTPPDEKKSVTLKWPGEPSLPVTDSPDPSVEIGPMGSVGQGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGK5</accession>
    <name>A0A7K2ZGK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF448 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000925">
        <property type="protein sequence ID" value="MYW31470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032770066.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000925.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8425" checksum="B04E2DA5BB212682" modified="2021-04-07" version="1">MGCRERVAKSELLRIVVDEGACAPDPRGTLPGRGAYVHPTSVCLDLAVRRRAFPRAFKAKGPFDTAALTRFVERVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH31</accession>
    <name>A0A7K2ZH31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5063 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000980">
        <property type="protein sequence ID" value="MYW31661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032025">
        <property type="entry name" value="DUF5063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038312">
        <property type="entry name" value="DUF5063_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16702">
        <property type="entry name" value="DUF5063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="24077" checksum="7226B2C79553FB1B" modified="2021-04-07" version="1">MSDATLNSVTQDPGDFAVQIADQIKTFIVAVTEVSKVDEPEEAVPVLLLQVSQLLLAGGRLGAYEDVLPDERYEPDLGPEPDADGLRERFAALLEPIDVYSEVFDPYEPRKAPVPHRISDDLADLVTDLGHGLAHYEADRTAEALWWWQFSYFSNWGSTASATLRALQSLVAHIRLGQPLEELDGLDTDQDPGEDDLAEEAGRVMLQEIAGPLGLRPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHR2</accession>
    <name>A0A7K2ZHR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001037">
        <property type="protein sequence ID" value="MYW31884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="13546" checksum="30F20C0FFB449E5C" modified="2021-04-07" version="1">MGTGPGRVLVWFYGVFTVAAASRSIVEVVRGFDRAPLAYSLSAVAAVVYGFITYSLVRGGERARRAALVCCAAELLGVLLVGAWTLAEPSAFPDSTVWSDFGMGYLFIPVILPVTGMIWLRRAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHS2</accession>
    <name>A0A7K2ZHS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001031">
        <property type="protein sequence ID" value="MYW31865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="96"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15353" checksum="F715CD64637B9C34" modified="2021-04-07" version="1">THTAALAPPVGRATLDRLLETRTALEALAASAARREQAAPATAAALNEVLSHGRIRRTLGTDGLPESAVELDEAAWGPAWYAADNWLHLVADRPDRIRPCANDACVLHFYDISKNGTRRWCSMAGCGNRAKAQRHYARRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHU8</accession>
    <name>A0A7K2ZHU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_22305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="405" mass="42450" checksum="C378CCDB2DA7F558" modified="2021-04-07" version="1" fragment="single">MIRFEQVSVRYDGTDRHTLSGVDLAVPEGELVLLVGPSGVGKSTLLGTVSGLVPHFTGGVLSGRVTVGGRDTRTHKPRELADLVGTVGQDPLAHFVTDTVEDELAYGMESLGLAPDVMRRRVEETLDLLGLAELRDRPIATLSGGQQQRVAIGSVLTPHPKVLVLDEPTSALDPAAAEEVLAVLQRLVHDLGTTVLMAEHRLERVVQYADQVVLLPAPGAAPVMGAPAEIMAVSPVRPPVAELGLLAGWDPLPLSVRDARRGAGELRERLASASPPEPPVNVNANVSIAAPPASPGPRPGRIARLLGRTKAVEAPGPADPVTRVESLSVRRGRLEALRRVTLTVAPGETVALMGRNGAGKSTLLGALVGMVEPTSGSVRVGGLAPARTDPRAMIRRVGLVPQEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI16</accession>
    <name>A0A7K2ZI16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_22650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001064">
        <property type="protein sequence ID" value="MYW31996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="422" mass="41870" checksum="F0E8B811401346E1" modified="2021-04-07" version="1" fragment="single">MQTPHAGTTASAPEHDSSTAQLDGGESERRATTPPAGAEEPAPTPGSRPGSVPGTGISPGTEAASGAPSGGGRTVALAVAGLTVAVLLLSGLSLSIGAGEVGVGGVLDYLLNRDGARDNARLSLVVGDLRLPRTLTALLVGAALGVAGCLLQAVTRNPLAETGLLGVNAGASLGVVAGIALLGFDSGYAYLVCAFVGAVVASGLVLLISGRRGGGSPMRLVLAGAALGATFGGLTSVIVVNSAETYDRFRFWVLGSLAGVEGFGELGRLAPVLAVGFLVALLVARPLSALALGDDLARSLGHRPPVIRTVVAIGVTLLTASAVALAGPISFLGLLAGFLARAIAGTRLAARLLLAGLIGACVLAVSDVAARVVSRPFEAPVSVIVALIGAPVLIAIVRSRQLASMGMTEPATEERAPDRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI30</accession>
    <name>A0A7K2ZI30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001063">
        <property type="protein sequence ID" value="MYW31975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="9640" checksum="0F5AE7C70C0A57D5" modified="2021-04-07" version="1" fragment="single">MTTIDWDAAAGSFDEEPDHGLLDPAVRDAWAGRLESWLPARRGDVLDLGCGTGSLSLLAAGQGHRVTAVDRSPRMAELARAKLAGTGAEVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIL8</accession>
    <name>A0A7K2ZIL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metalloregulator ArsR/SmtB family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001111">
        <property type="protein sequence ID" value="MYW32203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14332" checksum="B5B95DD01ED02AE9" modified="2021-04-07" version="1">MDPFIALADPVRRELLRALAAGPARVVDLAARHPISRPAVSKHLRLLTEARLVTAEDRGRERHYALDRPGLAPVRALLDELGGYRPPIPESAFDALDLEVRRTVHDRRVGTDAVPDPEAAPGTGRPQEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIT0</accession>
    <name>A0A7K2ZIT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_23970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001117">
        <property type="protein sequence ID" value="MYW32244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="298"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="389" mass="41461" checksum="F14C0AC8D1BD47F1" modified="2021-04-07" version="1">MGRAWRATRHLAVGFGLSCACLFLVALFLIGLAATALVVGAGMLPETVLTVRRFAGFERRRVGVWTGVEVPEAYALLTGTVVERLRGAADDPGTLRDLRWVGAQLVYGIALFCVAVVLWVPAIVVDGLWCRVLGRTPVVLPLLTRTTDLESAWSRALLTPSPQARLARRVEQLTETRAGAVAAHGAELRRIERDLHDGTQARLVSLSMRIGLAKRAYDTDPATGRALLDEAQTQAEEALTELRHVVRGIHPPVLTDRGLEGAVRALAASSALDVEVSVDGTDDGTRAPAAVEAAAYFAVAEALTNAARHSGAERASVTLTRTPRLVRVRVHDEGRGGAEEALTGTDPEQPRGTGLIGIRRRVAALDGTVRLTSPAGGPTDIEVELPCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIV0</accession>
    <name>A0A7K2ZIV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001123">
        <property type="protein sequence ID" value="MYW32264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007457189.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001123.1"/>
    </dbReference>
    <dbReference type="GeneID" id="63982918"/>
    <dbReference type="GeneID" id="66955444"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15913" checksum="023F2C7EFA446117" modified="2021-04-07" version="1">MAEGDALSTHVFGVQLGGYLVESIQEISGMTVEEEVVEVRQVTAEGKQIIRKQPGARQAGEVTITRGLDKSSEFTTWIKETLNNGAVDTARQNLTIEIKDSTGETVRRIQLMQGWASKWEGPSLKAGESSAATETVTITFEEIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIV7</accession>
    <name>A0A7K2ZIV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001129">
        <property type="protein sequence ID" value="MYW32283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="6077" checksum="827951E8F2EA1CDD" modified="2021-04-07" version="1" fragment="single">MTATGDYTIASLDTGLRAMRLFLTHDTLTVTEAAGHLRVGRSTAHRVLSTLESRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIX7</accession>
    <name>A0A7K2ZIX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_24145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001126">
        <property type="protein sequence ID" value="MYW32275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="194"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="29732" checksum="45A95ADF097BA020" modified="2021-04-07" version="1">EARIRRSDLVPEERTAGVTTQAARTDLLSTLGGEVARGTWLTPAGEHLPTTVLGAVAADRLGITRTGETIMMNETRVVVVGILRPIELVPTLDRVALVGFPAAERYFGFDGHPTTIFERSTDASVEDVRAVLARTISPGNAGSVKVSRPSDALAAKAATDKGLTTLMLGLGAVALLVGGVGVANTMVISVLERRQEIGLRRSLGATRNAIRLQFLTESLLLSALGGALLGAAATYGFARAQGWTTVVPPWSLAGGLAATLLIGVVAGLYPAIRASRLHPTVALNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIX9</accession>
    <name>A0A7K2ZIX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF309 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001134">
        <property type="protein sequence ID" value="MYW32302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="5634" checksum="B72C7D91B3A3E1E3" modified="2021-04-07" version="1">GARLLRRGAGALSPYGEARPHGIGIGGLVDWAQELAGRVESGPTVDAAAEAPRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ05</accession>
    <name>A0A7K2ZJ05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001137">
        <property type="protein sequence ID" value="MYW32307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="104" mass="10605" checksum="6B7377284FB23D69" modified="2021-04-07" version="1">DGTALGTGRLLHGADAAGKTGGDLTVGSLGRLAVTRQARGLGVGAALVRAIEDEAVRLGLTAVDLHAQTHALGFYERLGYVAYGPEFPDAGIPHRAMRRATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJJ2</accession>
    <name>A0A7K2ZJJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="5">4.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_24950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001165">
        <property type="protein sequence ID" value="MYW32429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="316" mass="33078" checksum="064B635D1709C325" modified="2021-04-07" version="1">MTIPAPGLPGRVRIHEVGARDGLQNEKETVPTEVKAEFIRRLAVAGLTTIEATSFVHPKWVPQLADAEALFPLLGDIADVGDVSLPVLVPNERGLDRALALGARSIAVFGSATETFAARNLNRTVDESLAMFEPVVARAKADEVHVRGYLSMCFGDPWEGAVPVAQVVRVAKALMELGCDELSLGDTIGVATPGHVTALLTALNDSAVPTKSIGVHFHDTYGQALSNTLAALQHGVTTVDASAGGLGGCPYAKSATGNLATEDLVWMLEGLGIETGVDLAELTATSVWLAEHLGRPSPSRTVRALTPSSSPASHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJJ5</accession>
    <name>A0A7K2ZJJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001195">
        <property type="protein sequence ID" value="MYW32504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="155" mass="17827" checksum="1E217AF960D02051" modified="2021-04-07" version="1">MPRWGLLVEQNLGLGGQRRVWSAGVMDHVDGTREEALEALRRRAEEYKPLHPASPKRRRLYRERDGFVLVLDGAWQSFHCRFTVMEELYDSAAPTPEPEPQAAPEPEPEPVQPPPPVRHRPVQRRAVQPPPEPERAWDADVPEVPSWLNRDRPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJP4</accession>
    <name>A0A7K2ZJP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SigB/SigF/SigG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_25600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001198">
        <property type="protein sequence ID" value="MYW32554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="121"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="210"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="29211" checksum="EED8ED0AA2E01B08" modified="2021-04-07" version="1">MQAVPTPGFPLDAGVPSTDGAFERLSALPPGPEREALRDETIRTWLPMAYRLAARFRGRGESMDDLRQVAAMGLVKAVDRYDPARGKAFETYAVPTVTGEIKRHFRDHTWDVHVPRRVQDLRNRVRTARRDLAQRLGGRAPTCAEIAAESGLAEEDVLLGLEALESYSALSLDAEPAGGEGSGATLADRLGSSDHALDVAVDREAVKPELRRLPERERTILYLRYFRDMTQLGIAERLGISQMHVSRLISRSCERVRAGALKGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKD6</accession>
    <name>A0A7K2ZKD6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pstC</name>
        <name evidence="12" type="ORF">GT040_26900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001253">
        <property type="protein sequence ID" value="MYW32803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="92"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW32803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="333" mass="35281" checksum="10E3A70D3C127177" modified="2021-04-07" version="1">MASTTPIDTPPAPPAPPDREERPQSTGRMGDKVFVGLSRGSGILLLVIMASIAVFLSYRAAIAISKDEGNFLTTFDWNPAGDPPVFGIAVLLFGTVVSSIIAMVIAVPIAVGIALFISHYAPRKLAAPIAYVVDLLAAVPSIVYGIWGALVLVPYLEGLNLWLDQFFGWTYIFEKTEVGVARSLFTVGVLLAIMILPIVTSVSREVFLQVPKMNEEAALALGATRWEVIRLSVLPFGRSGIISASMLGLGRALGETMAVATVLSPSFIISLHVLNPGGGTFAQNIAAKFGEADEFGRDALIASGLVLFVLTLLVNGAARLIIARRKEYSGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKE0</accession>
    <name>A0A7K2ZKE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_26940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001254">
        <property type="protein sequence ID" value="MYW32811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="PTHR10909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="3">
        <location>
            <begin position="285"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="ACOX" evidence="2">
        <location>
            <begin position="506"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="684" mass="74330" checksum="7E9CA3230F7D2670" modified="2021-04-07" version="1">MTVSMHEPPSPSTNDLLTRVLYGDNFRQEHGFWRRLITTEPFRRSGGGTPDERLALSYHRLRILNDALDSGARLAADPRALAALHEWLGPVDPALTTVAGIHYNLFLGSLLDHDPGTLRDLSDFLELRSIGTFLCTEVAHGNDAAAVETTATYDRERDGFVLHTPNSGAQKFMPNTSPAGGPKTGVVAARLLADGTDHGVFLFLAPLTDAVSALPGVRVRRLPARMGSPVDHCLTSFDRYFVPRKALLAGEQGRIGADGRFTSELANRRRRFLLSIGRVTPGKLSMSACAVGSARVTLALAIRYAGHRLVSGSRGSRRVPVYAHRTHHGPLAAAMATVFAMSLLHRRALDRWESAPAADRDEAERLVAVAKGWITWQARGVIVECRERCGAQGLLENNGMTELFTGIEGAITAEGDNLAVHAKAAAEMLFSVTVRDEEETEGPGDLDDPRFLGRLLAAVEDIWFDRARERISAAPPGDPLGRWNAASGPALRGVEAYGYRQASEAYEQAAAALPAGAARERLTELHRLFALRWVARNSGDLLAVGRLTAEQVSSLSDAVERLIATVALHAPDLVKSFALPERLMSDWPIAGPGYADAYDDPDGSWHQRRRAGGPVGRKAGATGLRTADFRRPACGSRRRRPLREKVAAIGTRGVLLAYWGTTSMLSRWFEKPQVSADESVRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKH8</accession>
    <name>A0A7K2ZKH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3626 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001262">
        <property type="protein sequence ID" value="MYW32845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="63" mass="6584" checksum="B87BD9572072152E" modified="2021-04-07" version="1">RHPGFRGPAYVGLGAALAVDGCLDARIIGDAARAGRHAEQDLKKVWHLLARFGRAPVILPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKL0</accession>
    <name>A0A7K2ZKL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 4">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hutI</name>
        <name evidence="6" type="ORF">GT040_27330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 4"/>
    <dbReference type="EMBL" id="WWKE01001272">
        <property type="protein sequence ID" value="MYW32886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="249"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="390" mass="40852" checksum="C55BE9A64E6D76AE" modified="2021-04-07" version="1">MTTTAVTHIASLVTNDPSLGNGTPLGLIQDAAVVIEGDRIVWTGESSKAPATDNVLDAAGRAMIPGFVDSHSHLVFAGDRTQEFNARMSGQPYTAGGIRTTVAATRQASDEQLSDNVARYLAEALRQGTTTLETKSGYGLTVEDEARALRVASRHTDEVTYLGAHVVPPDYADDPAGYVDLVTGPMLDACAPHARWIDVFCERGAFDGDQARAILTAGRAKGLAPRIHANQLTYGPGVQLAVELDAASADHCTHLTDADVDALGQGGTVATLLPGAEFSTRATWPDARRLLDAGATVALSTDCNPGSSFTSSMPFCIALAVRDMGMTPDEALWSATAGGAAALRRTDIGRITPGARADLVLLDAPSHVHLAYRPGVPLVSAVWRGGERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKW4</accession>
    <name>A0A7K2ZKW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001300">
        <property type="protein sequence ID" value="MYW32985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="205"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="526" mass="58695" checksum="CBD8DAE7569B618C" modified="2021-04-07" version="1">MAPDIPDFTDFTAIPRKGSRGRIVMLVDNSVHGDSRVQKQASSAAEAGWDVILLGKFSGKEEVRAWQLGDAEVRLLGVKAKMSTRPQDLRGAPIRRPLAYPSERVADFRTQQVKAWRADLRVRGAALRTGEDRSPLGSAGGQVWLAARRGAAKASSRWVKLRSRHTRKLRSIRRTRSAALDKATTAFWLTTMGDRAWRRLDPSVWDFELSYGPVIDALEPDIIHANDFRMLGVGSRAKLRARAAGRPVSLVWDAHEYLPGVRSWVNQRKLPAMVAYEREHARYADAVVTVSGGLADLLKETHKLPERPDVVLNAPEAAEASRFTALPVPDLRDLCGIGPDVPLLVYSGLAARQRGLDIMVDGLPELPGVHVAFVASHPELPYIRTLMKRAEELGVEDRVHAMPYVPHWQVVSFLSTADVGVIPIHHWPNHEIALITKFFEYSHARLPLVVSDVKTMAEMTRQTGQGEVFEAENVTDYVRAVRAVLDAPKRYTAAYEVEGRLDEWTWEAQAEVLDGVYTRLMRGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKZ1</accession>
    <name>A0A7K2ZKZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001302">
        <property type="protein sequence ID" value="MYW33003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="26"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="293" mass="30993" checksum="6513DD4B44FBE34E" modified="2021-04-07" version="1">MTHVARELASQPDCWRRAAGMAGGLAGQLPASGERIAVVGCGTSYFMAQAYAALREGSGQGETDAFAASEFPVGRRYDRIVALSRSGTTTEVLGLLAQAEGTRRTVIIGDPESPMATMADDTVVLDFADERSVVQTRFATSALTLLRAQLGLHTDAVVEDAQVALAEPLPAGLAECTQFTFLGRGWSVGLANEGALKMREAALSWSEAYPAMEYRHGPISISTRSTATWMLGDAPAGLSDEVHATGARWVAGGLDPLAELVRVQRLALAIAQARGLDPDRPRHLTRSVILSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKZ9</accession>
    <name>A0A7K2ZKZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_28045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001304">
        <property type="protein sequence ID" value="MYW33021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="17"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="430" mass="45345" checksum="7F8961BA27D3D915" modified="2021-04-07" version="1">MSITTVGAVYGCLGIGAFLAAALPRLLSRLPVSVPMVFLAAGVLLYLTPLPLPEIDPVADRLWTQHLTELCVITSLMGAGLAINRPFGWRSWAATWRLLGVAMPLTIGATALAAWWLLGWPASAALLVAAALAPTDPVLASEVRVGEPSDDEDDEDEVRFALTSEAGLNDGLAFPFVLAAVALAAAGESWTGGWLTHWAWSDVLVRIGVGVAAGTGIGLLLGRVLFRARAKSLRLAEHGEGFVALAAMFLSYGVTEALHGYGFLAVFATACALRRSERDHGYNKVMHGFVEQVERLLMALLLFAVGAFVASGGLTALTWRGAAIGVLLHVLIRPAIGWLAQLRGPGLPTERAATAFFGIRGIGSFFYLAYAVGEGGFGPYEREMWAVVVFAVLISVVVHGVAATPVTAYLDRRAANAPAGNQAGEKENAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL58</accession>
    <name>A0A7K2ZL58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="264" mass="28023" checksum="7CF8C86E59556D8D" modified="2021-04-07" version="1">MRIDLTGKSAVVTGSSQGIGLAIATGLAEAGAGIVLTGRGRERLDAAARSLRAEVAEAAVTTVACDLTTEEGAAQLYAAVPETDVLVNNLGIFGSRPPLEITDEEWRTYFDTNVLSAVRLIRHYLPSMTDRGWGRVLNIASDSAIVIPAEMIHYGMSKTALLAVSRGFAKEAAGTGVTVNSVIAGPTHTGGVEDFVYELVDKALPWEEAQREFMRLHRPQSLLQRLIEPEEIANLVVYLSSAQASATTGAAVRVDGGYIDSIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL69</accession>
    <name>A0A7K2ZL69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001318">
        <property type="protein sequence ID" value="MYW33104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="14062" checksum="173BC00BE9730D27" modified="2021-04-07" version="1" fragment="single">MSATTTLHSVSVRPALPADGETLGELDRSTWSTLHAVLPRPQPPYEPFFDERHRPEDFLVAEAATDVDGKRIAGYIRLVQPTSLACHAHVRQIQGLAVTVWARGAGVGRTLLRAACAEARRQGANRITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLF7</accession>
    <name>A0A7K2ZLF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dcm</name>
        <name evidence="10" type="ORF">GT040_28890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001348">
        <property type="protein sequence ID" value="MYW33176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="659" mass="74144" checksum="E55FB0FD4EE6733A" modified="2021-04-07" version="1">MTKQYYGVPLERSDQLKLPANRNSCKPAKFADWLDGYGKERRLAVDLFSGAGGLSLGLQRAGWTVAASVDSDERALETHAKNFPGMSLRMDLGKPEVRDELEALLKPAEGKIDLVAGGPPCQPFSRAGRSKIRSLVKHHGRDPEDHRKELWKAYLDVVKRLRPRAVLMENVPDMGLGDDFIVIRTIEQELEELGYATQVRLVDAWRYGVPQHRKRLILLARNDVEQFDWRPESERRTTLRDAIGDLPVLPVKAREKVGDREWQYSEPDELSSFAREMRKRAPKEHVWDHMTRRVREDDWLTFNEMTSKSLYSDVAPERRRYDAEQFTDKYKKLGWGDLSRSITAHIAKDGYWYIHPEQNRTLTVREAARIQTFPDRFRFAGTRSDAFRQIGNAVPPLLGQAAAEALLPVDGDESAEGGLQPYWRTVREDLTKWAAERRGGADWFQLPGERMSPLQAAVVALLSGTRLQSAQLAKMVAAVKGQKTLTQTAYRALLDAAPTESARSRVDRLAVVLGKPELWNDADAVPEQLKMKPAEATLYQLLTGKDLLWIGQAALRVAARLNGSDSDRTNRLSDGRVNLVKLVGAGEEAPLRMAALRLIGNTVCRSREPLCVECPLARYCVDKDNVASDLFTDTMSGERGGDSVPAQARETGRRTAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLM7</accession>
    <name>A0A7K2ZLM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein MoaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001358">
        <property type="protein sequence ID" value="MYW33252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510091.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001358.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16461" checksum="73BDCFBA8A864BAB" modified="2021-04-07" version="1">MARTQDHPGEQAASDPIRLLAIRESELSVDEVFRAVGDDAAGGIALFVGTVRNHDAGQDVGALGYSCHPSAEDELRRVAEKVVADFPVRGLAAVHRVGELEVGDLAVVVAVACPHRAEAFAACRKLIDDLKHEVPIWKHQRFSDGTEEWVGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLU1</accession>
    <name>A0A7K2ZLU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001355">
        <property type="protein sequence ID" value="MYW33229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="250" mass="26206" checksum="C75A51BD5CE07F84" modified="2021-04-07" version="1">MTVRPAHPSPRPPARPSLTGVTLAAVAGSVMVLAAAVLFALLPGSLSEARDFRAARPCAEIGGSAVENGDCLSEWPATVVSTGTGRKKKAVTYWITLDPGTEEQPFRIRMRGDGPVWKKLAPGSQVTVSSWRDVVWAVGLGELRQDTTTRPGYAPTVQLAVGLASLIVGAVFLRGSGWLHRRRAIGAPPARTSQILVPMAATFIAVAVAVTAAVATDRLWLVLLLAAAGCAMAWTASVLLVRRLAGVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLZ6</accession>
    <name>A0A7K2ZLZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF488 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001376">
        <property type="protein sequence ID" value="MYW33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="14374" checksum="60DBB551AFFCFAE1" modified="2021-04-07" version="1">MDDLVRVRRVYDPPEDGDGTRVLVDRLWPRGLSKERAAIDVWLKDITPSDELRSWYHQDRSGARHDTFVDRYRTELDDPAHTEAVDRLAGIVRAGGPVTLITAVKDVADSHVPVLVDHLQHVMKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM93</accession>
    <name>A0A7K2ZM93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_30440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001399">
        <property type="protein sequence ID" value="MYW33471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="37685" checksum="2AFBC77643E03193" modified="2021-04-07" version="1" fragment="single">MENVLRPLIVFGGSVVITLLIGWLVDRLLRRADSRHHETPLWGLLRRCRPPLQVVIIAALLRGSYRQTKIPWVWEHRVGIGQALSLVLIGATAWLVVRAAATVVEASYARYATSTRDPARVRRVRTQVTLIQRVVIAVVTVVAIAAMLLTFPAMRGVGTSMLASAGVLGIVAGVAAQSTLGNLFAGLQIAFGDMVRIGDTVVVDGEWGTIEEITLTFLAVRTWDERRITMPVSYFTSKPFENWSRGGVQMTGTVFFHLDHAAPVAAMRKKLRDILGDIAAWDGRDWSLAVTDTTPTTIQVRAVVTAKDADDIWTVRCAVREQLIGWLRDHHPYALPRIASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM95</accession>
    <name>A0A7K2ZM95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA-acylating methylmalonate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mmsA</name>
        <name evidence="4" type="ORF">GT040_30465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001401">
        <property type="protein sequence ID" value="MYW33475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="18"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="500" mass="53536" checksum="AAB5857C43D62827" modified="2021-04-07" version="1">MVRELTHFIGGKHTPGTSGTYGDVYDPNTGRVQARVPLAGRSETEAAIADAAEAQVEWGEWNPQRRARVLLRFLQLVEKEKDSLARLLSSEHGKTVADAHGDLARGLDVVEFAAGVPHLLKGEFSDNAGAGIDVHSLRRPLGVVAGITPFNFPAMIPLWKAAPALACGNAFILKPSERDPSVPLRLAELFLEAGLPPGVLNVVNGGKEAVDTLLEDPRVKALGFVGSTPIAAHIYATAAAHGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGEETADALVARLTERIAELRIGRSDDPDADFGPLVGRDAVDRVRSYVDLGVEEGAELVVDGRDFTLEGHEDGFFAGASLFDRVTPDMRIYQEEIFGPVVSVVRAADYEEALRLPSEHLYGNGVALFTRDGDIARDFTRRVETGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPDAIRFYTRTKTVTSRWPASGIRDGASFTIPTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMP2</accession>
    <name>A0A7K2ZMP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GT040_31305</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001437">
        <property type="protein sequence ID" value="MYW33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030570204.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001437.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="292"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="416" mass="43692" checksum="C8A46A7081F4E7FC" modified="2021-04-07" version="1">MDESGDSGRPQPGAGGTDPSAAPGSGKPKRPADPGGGLLMGRPFGVPVYVAPSWFVVAALITWVFGGQLDRVLPELGGARYLVALFFAIAFYASVLVHELAHTVAALRYKLPVRRIQLQFFGGVSEIEKETETPGREFILAFVGPLLSLVLGGVFYGAMRFVEPGTVPGVLIAGLMISNLIVAAFNLLPGLPLDGGRMLRAIVWKITGKPMSGTIAAAWVGRGLAVTVLIGLPLLTHTGALGSANEDIGGVETVMDALLAAILAGIIWTGAGNSLRMARLREHLPDLRARTLTRRAVPVESATPLSEALRRANEAGARALVVVDGQGNPKGVVREAAIVGVPEHRRPWVAVSGLAQDLTDGMKVPAELAGEALLDRLKATPATEYLVIEETGEIYGVLSTADVERAFVKAMARPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN03</accession>
    <name>A0A7K2ZN03_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein GT040_31830</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rapZ</name>
        <name evidence="2" type="ORF">GT040_31830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001449">
        <property type="protein sequence ID" value="MYW33735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030568016.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001449.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="301" mass="33146" checksum="15866FCA2FE0F34E" modified="2021-04-07" version="1">MSTNTTNETGEAVAPAIPELVIISGMSGAGRSTAAKCLEDLGWFVVDNLPPALIPTMVELGARSQGNVARIAVVVDVRGRRFFDNLRESLADLEAKHVTRRIVFLESSDDALVRRFESVRRPHPLQGDGRIVDGIAAERDLLRELRGDADLVIDTSSLNVHELRAKMDAQFAGESEPELRATVMSFGYKYGLPVDADLVVDCRFLPNPHWVPELRPFTGLNEEVSAYVFDQPGAKEFLNQYTELLQLIAAGYRREGKRYVTIAVGCTGGKHRSVAMSEKLSARLAAEGIETVLVHRDMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN27</accession>
    <name>A0A7K2ZN27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_31805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001448">
        <property type="protein sequence ID" value="MYW33730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="20425" checksum="46FD4564C6DF4578" modified="2021-04-07" version="1">MHLDPLAIITAFGLIFLAELPDKTMFASLAMGTRMRPLYVWFGTSSAFIVHVAIAVGAGSLIGLLPDWTVKLVSASLFAFGAFILLRGSGGDDDDDAEVKTVTGFWPVYSTAFMAVFISEWGDLTQITTANLAASNGTWSTAIGSAAALMSVSALALLAGKFIAKRVPLKTVQRVGGICMLGLAIWTAVEIFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN77</accession>
    <name>A0A7K2ZN77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001451">
        <property type="protein sequence ID" value="MYW33748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="76"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="301" mass="32199" checksum="02D23B57445C1068" modified="2021-04-07" version="1">DPRLVERPGPALPGYAALLTGAAGLLGVLALLWWRGALPAAAQSAVGLAPRPYESIGAGVWAGLALLVTVVVLALGGLGRGRVGYAWVLTLFGDYRGSVRRTGLVWVSPLLLRRRVDVRLRHWRSEPLPAVDANGTALRVVVLVVWRIKDTVRAALGIEDHEAYLSAQVESAMARVLSQLPADAFHEDAPTLRNAEAVGDALTRMLKADCEPVGVEVYSAQPTGIEYAPEVAAAMQRRRIAAIDAKHRDSVLTSVVDAVDDTVNRLTTRGIVDLDDYERKALVKDLTVAFYTGRTGGGDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNE9</accession>
    <name>A0A7K2ZNE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001484">
        <property type="protein sequence ID" value="MYW33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="26061" checksum="431BC132BA25244A" modified="2021-04-07" version="1">MRVEIWSDIACPWCYIGKARFEKGLAEFAHRDQVEVVHRSFELDPGRAKGETEQVIDMLATKYGRTREEAASMEANVAANAQAEGLGYRTEGRDHGNTFDIHRLLHLAKARGRQDELLTLAYRANFAEERSVFDDDVLLALAVEAGLDADEARAVLADPEAYADEVRADEREASELGANAVPFFVLDRRYGISGGQPSEVFVQALEQAWKDRPATALTTVGGDAAACDTDGACEVPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPK5</accession>
    <name>A0A7K2ZPK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3017 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001568">
        <property type="protein sequence ID" value="MYW34218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021385">
        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
        <property type="entry name" value="DUF3017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="112" mass="11827" checksum="164F003BDAF7AC63" modified="2021-04-07" version="1">RAASGDAPAPARQWPLLTVLGTAGAGLLIVALDPFTEAFRIGTILIGAALIAGAVLRWVVPAVGMLAVRSRFTDLVTYGLMGTLIVLLALVAQPRPWLDVPILENAVRFTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPV3</accession>
    <name>A0A7K2ZPV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_35130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001604">
        <property type="protein sequence ID" value="MYW34372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512078.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001604.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029579459" evidence="3">
        <location>
            <begin position="33"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="37"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="26780" checksum="B65D0BC3B8A53E59" modified="2021-04-07" version="1">MKQLLRALKRCSVVVATVAIAVVGLQPVTASAAPNPVVGGTRAAQGEFPFMVRLSMGCGGALYAKDIVLTAAHCVNGSGNNTSITATGGVVDLQSPNAVKVRSTKVLQAPGYNGTGKDWALIKLAQPINQPTLKIATTTAYNQGTFTVAGWGANREGGSQQRYLLKANVPFVSDAACRSAYGNELVANEEICAGYPDTGGVDTCQGDSGGPMFRKDNANEWVQVGIVSWGYGCARPGYPGVYAEVSTFASAIASAARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPY6</accession>
    <name>A0A7K2ZPY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_34905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001593">
        <property type="protein sequence ID" value="MYW34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="37760" checksum="1FD978ECDA57E089" modified="2021-04-07" version="1">MTDPHPFIAGLPKAELHVHHVGSASPRIVAELAARHPDSKVPTDPEALADYFTFTDFGHFIEVYLSVVDLIRTPEDVRLLTFEVARDMARQNIRYAELTVTPFSSTRRGIPEVAFMEAIEDARKSAEAELGVILRWCFDIPGELGIPGAEGTVRLAVERRPDGLVSFGLGGPEKGVERPQFKPYFDRAIAEGLHSVPHAGETTGPQTIWDALTELRAERIGHGTSSVQDPKLLEHLAEHRIALEVCPTSNIATRAVTDIELHPIREMVQAGVLVTVNSDDPPMFGTDLNNEYAVAARLLKLDEQGIAGLAKNAVEASFLDPAGKRRLAEEIDTYTANWLRGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ72</accession>
    <name>A0A7K2ZQ72_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="5">RF MTase</shortName>
            <ecNumber evidence="5">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">prmC</name>
        <name evidence="9" type="ORF">GT040_35810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001629">
        <property type="protein sequence ID" value="MYW34500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509917.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001629.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_25" evidence="7">
        <location>
            <begin position="115"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="31044" checksum="4145B32C7CE60125" modified="2021-04-07" version="1">MNLLLAEVAQATQRLADAGVPSPRFDAEELAAFVHGVKRGELHSVPDTDFDARYWETIARREAREPLQHITGRAFFRYLELQVGPGVFVPRPETESVVGWAIDAVRAMDVVEPVVVDLCTGSGAIALAMAQEVPRSRVHAVELSEDALRWTRKNAEGSRVTVHKGDALSALPELDGQVDLVISNPPYIPLTEWEYVAPEARDHDPEMALFSGEDGLDTIRGIERTAHRLLRPGGLVVIEHADTQGGQVPWIFTEERGWADAADHPDLNKRPRFATARKAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ73</accession>
    <name>A0A7K2ZQ73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_35645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001625">
        <property type="protein sequence ID" value="MYW34467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="130" mass="13897" checksum="14093F08E8E50535" modified="2021-04-07" version="1">MSEKPARHLSQAAEGVRAFNHTSLSVGDDWVYPGHAYDAVGNLSHMVGMLEQAVQQSTRPVMHTYEHGRVRIDGNGDADAKVAELVAAQRDAEAAAAALTAAVQRMHNAVSPMGLDTTGIPEFEDDEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR88</accession>
    <name>A0A7K2ZR88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase TatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001698">
        <property type="protein sequence ID" value="MYW34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012022">
        <property type="entry name" value="UCP005295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42658">
        <property type="entry name" value="PTHR42658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005295">
        <property type="entry name" value="UCP005295_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="31246" checksum="254AED7CBD5BC0EE" modified="2021-04-07" version="1">MRIFDPHIHMTSRTTDDYQAMYDAGVRALVEPSFWLGQPRTSPASFFDYFDALLGWEPFRASQYGIAHHCTLALNPKEANDPRCTPVLDALPRYLVKDSVVAVGEIGYDSMTPAEDHALAAQLQLAADHGLPALVHTPHRDKLAGLHRTIDVIRESDLPPEFVLLDHLNETTVKAATDSGCWAGFSIYPDTKMDEDRMVTILQNHGTEKMLVNSAADWGKSDPLKTRKVADAMLKAGFTEDDVDQVLWRNPVAFYGQSGRLHLDTPAPDALHEGNSILRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRJ2</accession>
    <name>A0A7K2ZRJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tellurium resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001732">
        <property type="protein sequence ID" value="MYW34966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="244" mass="27481" checksum="DACA2282E998D12A" modified="2021-04-07" version="1">MGFFDGLWPGRAAQFDSGNGTSSAIVLSKRNATVSLSKQGALSGNLRVNLSWRMRTSDIEGRSRQSGRLRRPLKLFQPEVVQAHTQGVVNVDLDLGCMYELTDGTKGVVQPLGNLIGDLNSPPYIRLSGDDRFGAPSGETVYVNLDQRDQFKRLLFFVYIYDRTPAFDRTHAKITLYPGNGPRIEIELDERAPQARSCAVFTVENVKDELIVRREVKFVYGFQSELDRLYGYGMQWGRGYKSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRU0</accession>
    <name>A0A7K2ZRU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_38765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001770">
        <property type="protein sequence ID" value="MYW35066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029864558" evidence="10">
        <location>
            <begin position="44"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="11">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="12">
        <location>
            <begin position="353"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW35066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="636" mass="65811" checksum="11DFE6910B988454" modified="2021-04-07" version="1">MTATAPRPGASPIRRPFTAAALAAALVSLVFGLILAGAGPASAHAALTGSDPQDGAVVATAPKEVTLTFSEAIAVGDGSIRVLDPSSKRADTGAEPKDLSDGSTVRYGVELHSGLPDGTYTVAWQAISADSHPISGAFTFSIGAPSETTVALPSEEVGGGPVGTVYGIARYVAYAGFTLLVGGAAFVLGCWPRGASVRPMQRLVVRGWVTLTAATLVMLLLRNPYTGSGKFADAFDLDGLQAVLDTKPGAALVSRLLLLGAAALFIAVLFGTYARREDAVEKKDLTFGLAVGGGVVAAGIAATWAMSEHASTGIQAGIAMPFDVLHLLAVAAWLGGLVSLLVALYRTPDIGSEAVRRFSRVAFGSVLVLAATGIYQSWRQVGSWSALTGTRYGQLLILKVVLIAVLLAVAWFSRRWTGRLTDTAVPASVEPEAATEPDAEVPDGVDPARAAQLARQQAVLTATKKKRIRDADPERSGLRRSVLAESAIAVVLLAVTTVLTSTEPGRTEVEAKGASSTAPAPAAGPVNLSMPFDTGGQNGKGTIRIDIDPGRTGSNEMHVWVDGGDGKPMDVPEVKVALTLEAQEIGPLPVVPDRLAEGHWSASGVQIPMAGEWKVDVTVRTSDIDQVTIDKNVKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS06</accession>
    <name>A0A7K2ZS06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001771">
        <property type="protein sequence ID" value="MYW35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14671" checksum="7825EEAFB15BC8FC" modified="2021-04-07" version="1">MTALPSPLLTVTAEEGRGWVRLRLTGDLDYDTSHELVVRAGDRLAVRPDLRDLRLGCAELRLCDSMGVSALLQIHRDAAAQGVALHVEDAPPFLERIMRITGIDHLFARQEERRPARGAGEAAPPSDQRPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS84</accession>
    <name>A0A7K2ZS84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001811">
        <property type="protein sequence ID" value="MYW35240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="155" mass="15237" checksum="5D2239C2356F058A" modified="2021-04-07" version="1" fragment="single">RGPAADEEQAVPELIPARQGEGSGRRRGRPSPAESGAEGAGAAGVGGEAGENGGAESGPPQIGPPQAGSPQTGSPQTGSPQIAQQQAQQQQPQRQALALTSAASSAPSEGSVVTAAEGAQGAGRPQRGQTVPPQGVPVDPQQPVPPAGRRARREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSF2</accession>
    <name>A0A7K2ZSF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001829">
        <property type="protein sequence ID" value="MYW35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="19788" checksum="DE1936BFE15156A9" modified="2021-04-07" version="1">MPGQVTAVSRNEGYSFSKPPRDSIRLLTGLGVEGDVHAGETIRHQFRMTYEPDLPNLRQVHLMHEELFDELALKGLEVSAGQLGENITTRGVDLLGLPTGALLHLGEQAVLEVTGLRNPCSKINDFRKGLLGEVFAMDPLSGEFTFKCGVMAVVRCGGTVRPDDSIHVEPPPTPHRPLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSG1</accession>
    <name>A0A7K2ZSG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_39700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001809">
        <property type="protein sequence ID" value="MYW35238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="18224" checksum="E66820E176746E12" modified="2021-04-07" version="1" fragment="single">PPLALAAAADLAASALNPSMDSWDQAPAASALEADLTTALAAEIYPHTPSPDAVITTGGTEANQLALLLARERHGPVQTVCATNTHHSVARAAWLLGLPEPVTVPAPDDTMDPAALAQTLTRLDRPLLVVATAGTTDTGAIDPLDTIADLCATHGAELHIDAAYGGPLLFSPTHRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSH2</accession>
    <name>A0A7K2ZSH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001782">
        <property type="protein sequence ID" value="MYW35169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="384" mass="40285" checksum="0E653C0C993A15E3" modified="2021-04-07" version="1">LRTAAEQWADTSRIDFTAWPVRGDRRGDDELLGRALRAWAEPPGNVRVSTTPGTVGVPPAQPPRLLFAGEVDGAAVVLFHDGGVRIVRYAEPPAGGDGATLDFARTDDADVTTGAAVVVSRTGEKARFLLAPWISETTTRDLLAPDTPGRPLEVGPDGITAPVGRPAAGGACDAWPVLQLRSSERIVEKHAFLVTDLGDLAPAHLTYTPKPGGGAPARQPREATGPEALLAWARTACSLRALSGSGVRAVNNWAFAEQRLPEGEASAEWLCTRADTWRGPGRVLVQFLQPAASPTAPAAVVADRNDTALCSRFGQHILAGTHWKAASGRWYVLAAGSRAVNRIEATGQVRGAAGGPTLAVRAPRDASVELTAKLREGGTLAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSH4</accession>
    <name>A0A7K2ZSH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2236 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001836">
        <property type="protein sequence ID" value="MYW35344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="PTHR37539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="103"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="406" mass="44295" checksum="D656E3376D5AC541" modified="2021-04-07" version="1">MTSAPATAYTQASLDALRRSGDELADATVATLFERGEVGTFNTLMRYVSTAGAPLPDGLPDVAREYLNATAAPPSWVDWGEMEKARLFFIDNNVHISTALSFASMPACYVVPHVAKLLSATHGLNYPSKRMAETGQFTVHLMQPDAFEAGSRFIPAAQKVRLLHASIRHHLRREGAWDTEGAGVPICQEDMIGGQMFFSMLVLDSLHRLGIHMSEEGADAYYYAWRVVGAMLGVDQDAVPKSLVEAREFLDLYMIRHMGPSPEGALLTRQLIDLYEEVVPGTFFDPIVSALIRHLVGDTCADWLEVPRTPWDTVAKAVPHLLGVLETIEDRSPLGAWALDRIGHLTTVLELSSLTRGRVMHYAIPEHLKKEYGVPSGPARTGRWSPPAATVPGPRQGTPAGGSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSL8</accession>
    <name>A0A7K2ZSL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF262 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001840">
        <property type="protein sequence ID" value="MYW35380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="2">
        <location>
            <begin position="46"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="406" mass="46947" checksum="178D158CAC7738B5" modified="2021-04-07" version="1">MTNPEAEEAEAYDDLDGEESEASEDVSSSDVQRAVVTDTDWTTETILSQLRRGNIQLNPRFQRRDAWDKARKSQFIESLILGLPIPQIVLAEDKRRRGKFIVLDGKQRLLALRQFSAGSTLAASDEDDPFEGFALSRLDVRKDLRNKTLAKMERESELDDDLNAFLNETIRTVVVRRWPNEEFLNLVFLRLNTGSVKLSPQELRQALHPGDFTDYLDDAASASVPLRRALRIKKPDFRMRDVEIMLRFFAFQYRLNEYTGNLKAFLDGTVNRLNDEWETQKDSIQERAKSCEDAIEATFTIFGPNAFFRWSEEGYEGRFNRAVFDIMTYYFSNREIAEAAVENRNEVESSFKWLCENNSHFVESIQTTTKTPLATHRRLSLWGEQLSQATSLELDVPKFSDNRLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSP7</accession>
    <name>A0A7K2ZSP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">GT040_40265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="WWKE01001836">
        <property type="protein sequence ID" value="MYW35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241849.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001836.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="427" mass="45977" checksum="3D0297743D167D1C" modified="2021-04-07" version="1">MPALVLLGAQWGDEGKGKATDLLGGSVDYVVRYQGGNNAGHTVVVGDQKYALHLLPSGILSPGCTPVIGNGVVVDPAVLLSELSGLNERGVDTSKLLISGNAHLITPYNVTLDKVTERFLGKRKIGTTGRGIGPTYADKINRVGIRVQDLYDESILEQKVEAALEQKNQLLAKVFNRRAIEAGKVVEDMLQYAEQIKPFVADTTLILNDAIDEGKVVLFEGGQGTLLDVDHGTYPFVTSSNPTAGGACTGAGVGPTKISRVIGILKAYTTRVGAGPFPTELHDEDGEALRRIGGERGVTTGRDRRCGWFDAPIARYATRVNGLTDFFLTKLDVLTGWEQIPVCVAYEIDGKRVEELPYNQTDFHHAKPIYENLPGWSEDITKAQTFDDLPKNAKAYVKALEEMSGAPISAIGVGPGRTETIQINSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSQ1</accession>
    <name>A0A7K2ZSQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">corA</name>
        <name evidence="7" type="ORF">GT040_40500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001841">
        <property type="protein sequence ID" value="MYW35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="36463" checksum="B9049E2AC102D347" modified="2021-04-07" version="1">MIVDCAIYQDGRRTDGPADFSDALDEARKSGDAFLWIGLHEPTEREFDLVRHEFGLHPLAIEDALRAHQRPKLEVYDDSLFAVLKPVVYESSSDTVSADELMVFIGDSFVVTVRHGDSAPLADVRSRLEADPQILAHGPTAVLYAISDAVVDHYIDVAGELQVDLEELETEVFAPSASGDSSNTAASIYTFKRQVLEFRRATGPLTAPMTRLAGAGVPFVHQEAQPFFRDVADHLTRVNEQVEGLDRLLSDILSAHLAQMGVRQNDDMRKISAWAAMAAVPTMVAGIYGMNFDHMPELHWAWTYPAVILFMALAVFGLHRQFKRRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSR9</accession>
    <name>A0A7K2ZSR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001841">
        <property type="protein sequence ID" value="MYW35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="327" mass="34975" checksum="B9B5DDDA8EAAB356" modified="2021-04-07" version="1">MEQRHLGRTGLRVSRIGLGTLTWGRDTDEHDAADQLKAFWDAGGTLVDTADVYGGGEAEYLLGRLVGSLVPREDLVIATKAGNVPDPYRRFNGSRGHLLAALDASLERLGTDYVDLWQVHAFDPATPLEETLQAVDLAVSSGRVRYAGVSNFCGWQLAKAATWQLAAPGVRTRLASTQMEYSLLQRGIEREVLPAALDLGIGLLPSSPLGRGVLTGKYRKGTPSDSRGASERLAPFVEPYLDDAAARITDAVATAADGLATSPLHVALAWVRDRPGVAAPIVGARNAGQLAEALSVEALSLPYEICQALDDVSAPVHRYPDQDWSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSS2</accession>
    <name>A0A7K2ZSS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_39820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030803885.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001828.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16371" checksum="CF779462479B3598" modified="2021-04-07" version="1">MDAVDRQLIQALRENGRASYAELGRLVGLSGPSVTDRINRLETAGVITGYRATVDSASLGLGVTALIGISLSDAADHEDVAHRLKDLAEIEDCWFIAGDDSYMLKVRVGDVDGLEKTIRRLSGTKGVSRTRTTIVLSTKWENRVGELPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSU2</accession>
    <name>A0A7K2ZSU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_40595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001845">
        <property type="protein sequence ID" value="MYW35402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="329"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="460" mass="48333" checksum="319389CE7645C6EF" modified="2021-04-07" version="1">MAYQLSGSQPGLTADLTRAHAGTPAAPAFAIQVNALQAMCRQVFGFRLAMIAIATPYAIGHTAPGLPTWFIGSAVLVTFMGSYVLFRDWERFGPVLLRHPWLLAVDVAFGSLLLITATPESTLAYVTVCTPLLAGLVQGWRGAAVFAALQVVIVFGVYASVPKLEAGGATGLLLPGFCVIAGAVGVTLRNLLLRFGTATQALTETRARLAVNEAVEGERTRLAREMHDSVAKTLHGLALAADGLACSADRMDPPTVRHQAELVARAARRAAAESRELLTDLRREQGLEGGVDLVAELAAQAADFTARHPVTATFRRLAEDTPVPPVPQAVARQLLTVASEALENAHRHAGPTYLVVLAGVKGDVLRVSVYDDGRGLPAGTTLESLRRAGHFGLVGMVERAASIGARIRIGRGRAERGTEVRVELPLAALAPPPTPPPPFTPAPDGAGVTATEATPHLSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSX7</accession>
    <name>A0A7K2ZSX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001863">
        <property type="protein sequence ID" value="MYW35456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="9917" checksum="4820FFAA65EB04B7" modified="2021-04-07" version="1" fragment="single">MADEQDEWLDKDAAEKLLRGEPVVPLGDQARDDAFRLAEALGAARAVRRTPAGELPGEDAVLTAFRQATRAGGDRLAGRSAGAALPGQPGTLHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5X4</accession>
    <name>A0A7K2Z5X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000006">
        <property type="protein sequence ID" value="MYW27745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="401"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="609" mass="65075" checksum="B48D0FA235686F53" modified="2021-04-07" version="1">MEGMSESENVSTMPEWEQRFRAPRVSLPDWAEDAPDRSLFVSNATGTYELYAWDRAGGQQRQVTDRPNGTTDGVLTPDGEAIWWFSDTDGDEFGVWMRQPFGGGEDEPAAPGLAPSYPAGLAIGRDGSAVIGRSTDEDGTTIHLVPAPGSGEAVEIYRHRESAGVGDLSHDGTLIALEHTEHGDAMHSALRVVRPDGSTVAELDDTEGGTKELGLAVLGFAPMAGDPRLLVGHQRRGRWEPMIWDPVAGTETALPVDLPGDVGAEWYPDGSALLIEHSFEARSELWRYEPGAAEPVRVETPAGTVSGATARPDGTVEYLWSSAAQPPVVRSTSGAVVLDPPGAKAPASVAVEDAWVEGPGGRIHALVQKPATGDGPFPTVFEIHGGPTWHDSDAFVSGPAAWVDHGFAVVRVNYRGSTGYGRAWTDALKHRVGLIELEDIAAVRDWSVKSGLADPQRLVLAGGSWGGYLTLLGLGTQPDAWALGLAAVPVADYVTAYHDEMEALKAMDRTLLGGTPEEVPERFEASSPLTYVDAVRAPVYISAGVNDPRCPIRQVENYVDRLAARGAVHEVYRYDAGHGSLVVEERIKQVRLELEFALKHLGGGDVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z605</accession>
    <name>A0A7K2Z605_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000012">
        <property type="protein sequence ID" value="MYW27775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="161" mass="17386" checksum="8669740C19A35ACB" modified="2021-04-07" version="1">MSERRALRELRVLMWVVIAIEVPVYLVWLVQVGYLTGQELPRGDVARWAPPVLLPPAAVLFCVMAGWTWWLSVVAGTRSALRERWIVVSLVFVAAFSVFCGVASVDDPSVSVGLLSAAVTGLGMTGLFFIPAAASRQLPDVIRRRAAERRAGSAPAGPDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z654</accession>
    <name>A0A7K2Z654_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_00580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000017">
        <property type="protein sequence ID" value="MYW27802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="964"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1020"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW27802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1334" mass="141558" checksum="285836BC5C6ACDD4" modified="2021-04-07" version="1">LWFLHQLDPEAAAYHMAFAVRLDGGLDRQALRRALGDVLTRHESLRTVIEPGDGSPRQHVLAPGDALPELPLVTVEEPRLDEALRQAAAEPFDLTHDVPLRPVLFRSGEDRHTLLVTVHHIAADGWSMGPLAQDLAGAYAARSAGRAPSWTPLPVQYADYTLWQRDLLGSFEDPVSAASAQLAFWKDRLAGAPEETALPGDRPRPASPGGRGGTVPVHVPEETVAAVVRLARSTASSTFMVLHAALAALLHRMGGDSDITIGTPVAGRTDEALDPLVGFFVNTLALRTDLGGDPDFTELLGRVRETDLAAYAHQELPFERLVEAVRPTRSLSRHPVFQVMLTLNNHRPPRLDLPGLEARLEGVDTGGAKFDLSFSFTERTAAGTSTGTGTATGGAYLDGTLEFSQDLFDAGTAVRIADRFALLLAHAVRDPATVVGDLPLISAEEQRRLLDLGGSESVSRQGAVPPVTVLDRFAATVASARSRDIAVTAPDGSLSFAELDARSDRIAALLARAGADTGDRVAVLLPRGTDSIAALLGVLKAGAVHVPVDDSLPQGRIDAVLADARPHTVLTADATHTRATPHWPRLNLDSPDAATAPAPLRERARPGPADAAYLLHTSGSTGRPKGVLVGHGSLARLLEHHRRHLFGPSVRAAGKPRLDVALTAALSFDAAWDPVLWMLDGHRLHVLDDLTRRDPEALVEAVDVLGLDVLESTPTHVRQLLDAGLCAGAGRAPSVIVLGGEAVPADLWDDLRARPGLSAWNFYGPTEATVDTLTADLRATGRPVLGTPVEGTAVRLLDDRLRPVPVGVTGDLYLAGDSLALGYHGQSAATASRFVPDPYGPAGTRMYRTGDRAVRTPEDALEFAGRADGQVKVRGFRVEPDEIAAVLAEHADVAQAAVVAHGEGSGGSRLAAYVVLAAQSAGLTQPPAERLDELRKHAAARLPGYMVPSGWVALDGIPLTPNGKLDRKALPDPAPQAAPGVAGRSPRNPREDVLCTLFAEVLEREQVLIDDDFFALGGHSLLAAGLIRRIRDALGADVSIRSLFEAPTVAALAERIGAGVQDNPLATLLPLRTRGSLPPLFCVHPAGGLAWSYAGLLPHLGADRPVYGLQTPNLDGTEPFPDSIEAMAAVYVAELRAVQPHGPYHLFGWSFGGNVVQEVAVQLQEAGQEVALLTILDAFPLAPLDDLDSASRDTVFRALLSNMGVGQEALDGDGPVEATAVRDQFLANGSPLGALEPATIDAMVDNFAGQARLMRKYTPRVFHGPALFFTATEGRPRDTFGLSLWDPYIDGPIENHDVACAHAQMMQPAAREQIGTTVSAVLDAGHRTERGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z685</accession>
    <name>A0A7K2Z685_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_00865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000034">
        <property type="protein sequence ID" value="MYW27857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="348"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW27857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="580" mass="62507" checksum="FED68CC39C57DD4C" modified="2021-04-07" version="1" fragment="single">MVEGAEVVAHGRQRRCSDGAVTTNVVGGGTLSRPGALRASHRGEHAVGQGNAEPTGKPKRPATAGWTTKRWLAVTAAASLSLLLALMLFGGWILARSTAINTRLIDHSTPALIAAVRLESALADQETGIRGYAVTGQDSFLAPYREGLRQQEKAMTDLRTATGGDRATERDLSEVVRRAGQWQARIARPVVAAADPKAAAAERAVEGKALFDSVRSAASAQQERLAADRAGARADLQEARTLRNWSFSAIALAILALTASVFVGLRRGVTDHLDRLSGHVRTVAAGEFGHPVAGTGPADLRLLAADVESMRARLADELTHRDVAQANLAAQTEELRRSNAELEQFAYVASHDLQEPLRKVASFCQLLERRYAGNLDDRARQYIAFAVDGATRMQSLISDLLDFSRVGRLATEHQSVDLDEKFERTLASLSLAVEESEAVVTHDPLPVLEGEPGQLGMLFQNLLTNAIKFRSPDRAPVVHLGCRPVDDGWEFAVTDNGIGIEAEFADRVFVVFQRLHTREQYAGNGIGLALCKKIVEYHGGTIAVDAAHSPGTRIVFTLRKAPPRVLLPRPLDGERGPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6H6</accession>
    <name>A0A7K2Z6H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_01140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000056">
        <property type="protein sequence ID" value="MYW27912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029847406" evidence="8">
        <location>
            <begin position="24"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW27912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="33734" checksum="C955C98AC3286480" modified="2021-04-07" version="1">MRGASRRRLVILVLAVLVVAAFAVTLMAGRTFYPPGDVWRVILGEQVPGASFTVGRLRLPRAVLALVAGFSFGLAGVTFQTMLRNPLASPDIIGISSGASAAAAIAIVTLSLGEVQVSVLAIAAGLGVALLVYSLAFRGGVVGTRLILIGIGISAMLDSVTSYVLSQAAEWDLQEAMRWLTGSLNGATWDQVLPALAAAAVLTPLLLGQARSLSAMQLGDDTASALGVRVERTRITVIVAAVGLIAFATAAAGPIAFVAFLSGPIAARIVGAGGSLLVPAGLVGSLLVLVADFTGQFAFGERYPVGVVTGVLGAPYLVYLIIRTNRAGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6H7</accession>
    <name>A0A7K2Z6H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF885 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000058">
        <property type="protein sequence ID" value="MYW27941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="562" mass="61917" checksum="F6DE7F6B6613B8DB" modified="2021-04-07" version="1">MSDTSSSALPRQVADTYVDAVIELDPITGTYLGVPESSRRLPDFSPAGQDATADLIRATLLKLDDAERLPGAGSDEERRCGRLLRERLTAELAVHDAEEGLRAVSNLHSPAHSLIGVFTVTPTETEEDWAAVAERLRAVPAAVEGYRASLGLGLERKLYGGPRATATFIGQLTEWSGGGESTAFFTDFIAPAPEAPRPELTEGARLATAAFASLRDWMRDVYAPAIEGAPDTVGRERYARWTRQFNGTDLDLDEAYAYGWSEYHRLLAEMKTEAAKILPGAGPWEALAHLDVHGKHIEGVEEVREWLQGLMDEAIEALDGTHFELAERVRRVESRIAPPGGAAAPYYTGPSEDFSRPGRTWLPTMGETRFPVYDLVSTWYHEGVPGHHLQIAQWKHVADSLSRYQTSLGQVSANAEGWALYAERLMDELGFLPDAERRLGYLDAQMMRACRVIVDIGMHLELEIPADSPFHPGERWTPGLAQEFFGNHSGRPADFVESELTRYLSMPGQAIGYKLGERAWLLGRENARAAHGDAFDLKAWHMAALSQGSLGLDDLVDELSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Y2</accession>
    <name>A0A7K2Z6Y2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GT040_02135</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="WWKE01000100">
        <property type="protein sequence ID" value="MYW28101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="13">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="158"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW28101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="964" mass="104661" checksum="EB56931C485427DE" modified="2021-04-07" version="1">MTETASGPARGSRTKGTKASKGLRIERIHTTPGVHPYDEVAWERRDVVMTNWRDGSINFEQRGVEFPDFWSVNAVNIVTSKYFRGAVGTPQRETGLKQLIDRIVKTYRKAGEENSYFASPADAEIFEHELAYALLHQVFSFNSPVWFNVGTPQPQQVSACFILAVDDSMESILDWYKEEGMIFKGGSGAGLNLSRIRSSKELLSSGGNASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEAFIETKVKEEEKIRALRDAGFDMDLGGDDITSVQYQNANNSVRVNDEFMKAVEAGGKFGLRARMTGDVIEEVEAKSLFRKMAEAAWACADPGIQYDDTINAWHTCPESGRINGSNPCSEYMHLDNTSCNLASLNLMKFLKDDGLGNQSFESERFSQVVELVITAMDISICFADFPTQKIGENTRAYRQLGIGYANLGALLMATGHAYDSDGGRALAGAITSLMTSTSYKRSAELAAVVGPYDGYARNAEPHQRVMKQHADANAKAVRTDDLDAPVWAAATEAWQDVVRLGAKNGFRNAQASVIAPTGTIGLAMSCDTTGLEPDLALVKFKKLVGGGSMQIVNGTVPQALRRMGYQPEQIEAIVAHIAENGNVIDAPGLKPEHYEVFDCAMGERSISAMGHVRMMAAIQPWISGALSKTVNLPETATVEDVEEVYFEAWKMGVKALAIYRDNCKVGQPLSAKTKDKEKEEVTAKAEETIRTAVEKVIEYRPVRKRLPKGRPGITTSFTVGGAEGYMTANSYPDDGLGEVFLKMSKQGSTLAGMMDAFSIAVSVGLQYGVPLETYVSKFTNMRFEPAGMTDDPDVRMAQSIVDYIFRRLALDFLPFETRSALGIHSAEERQRHLDTGSYEPSFEAEGVDSESLAQSAPVQPELKAVAAPRESAEKPAPATAHTSAELVEMQLGISADAPLCFSCGTKMQRAGSCYICEGCGSTSGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z707</accession>
    <name>A0A7K2Z707_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1932 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000103">
        <property type="protein sequence ID" value="MYW28131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1932" evidence="2">
        <location>
            <begin position="188"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="29176" checksum="FC77A7553AA31580" modified="2021-04-07" version="1">MITVTVLHPGTMGAAITAELVAGGHEALSVTKGRSENTWVRGREAGATTYDSLAEALSRSAVVLSVCPPQAAEDVAAAVAAHGFAGVYADVNAISPQRVRRIADEIRPGSAVVDGAVFGQPPGEGRATRLYLAGADSAVELVASLFTDSALHVCRVGDTVGSASALKMAFSSYQKAARTLAGVAHALADAHGVGNQLTAEAEIMISAILSDPEYLPSVAARAWRWAPEMEEVADTLRAADLPPDMAEATARVFAFWEQDKGRYDLPVAHVLAQLRSGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z794</accession>
    <name>A0A7K2Z794_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000111">
        <property type="protein sequence ID" value="MYW28183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="35620" checksum="CE53C612A4A260F7" modified="2021-04-07" version="1">MIPSTPVARWTWGRDIAPEDKIFACLHDLMAAWSVLANYQLVVGIPRISVSVHEAGASKNQLFQGCLEPDVTNPTSRAVDELAQQVEAALSPGEIGAVYAEAEGIGGIVIGDRAARKERLFLVGASAVLDYVSTELVTFSDAWMPYDLKGQAQADVYAANAQKLSAALHGMSEALHSEIDPDEPTYFAKPTESGVDNYREDDGTPSDVWSSFEVPHRYGKFTHAPGFGHIGYKRSAEGPVLYVPVRGPREVIGYLWASDAEGAASFEPRNVSDDESYEAGLMWLDRLRSAHDRGLSPTEALAELTGPLDQSNPSTVDLASLREMSHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7B4</accession>
    <name>A0A7K2Z7B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000114">
        <property type="protein sequence ID" value="MYW28205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="172" mass="18435" checksum="72696B3701D81004" modified="2021-04-07" version="1" fragment="single">MTSVHTSARSEADDAVARPTWPGAPDGVLEPAERPIAWSMLSRALSVPLILGLVCFLPAVIAAQPGNGVRDTVYWLQLVLTCYAGARLATMILSTRRRLLQGVFWMFVYIAMGVAPFAQVVIGQTPTPMVGPRQDLITATAMVLVGCAAYDLGALLASRRPLRRRTASARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7J5</accession>
    <name>A0A7K2Z7J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15982" checksum="16B49A3A63C9D8EF" modified="2021-04-07" version="1">MAHHIGRSFGGPGDCEALCPCPKAPCGLVDMDNVSDECEQHPPLRCKTIHTGHRPEDCPGIGRDVVVAMKRTAEARQAVIDAACMEPEGFVNASILGAIDDYRAAVEHEAAERIRNSERLRDYTDDHMGDMRAAADEIDPDVEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7L9</accession>
    <name>A0A7K2Z7L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11351" checksum="921362616CBB5CBD" modified="2021-04-07" version="1">MGRLDIGDIDGYYLHALEAKAEKTITLASYIAQANKEAVNADQPYGCAIVKRRMKGTADGYVVRDVATDVRLMNRMRDMEDALQGENSALYEALDKQHREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7R3</accession>
    <name>A0A7K2Z7R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000150">
        <property type="protein sequence ID" value="MYW28381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="19759" checksum="E33479E366313CDE" modified="2021-04-07" version="1">MSIGHTLLGLLESGPRHGYDLKRTFDEKFGQDRPLHYGQVYSTMSRLLKNGLVEVDGIESEGGPERKRYAITDAGITDVSRWLMQPEKPEPYLQSTLYTKVVLALLTDRSASDLLDTQRSEHLRMMRILTDRKRKGDLADQLICDHALFHLEADLRWLELTAARLGQLAKVVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7S2</accession>
    <name>A0A7K2Z7S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_03485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000146">
        <property type="protein sequence ID" value="MYW28358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_031127054.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000146.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="262" mass="28125" checksum="F6AD2F750339E99F" modified="2021-04-07" version="1">MVHVTATPVLALRGVSKRFGAVQVLTDVELEVHAGEVVALVGDNGAGKSTLVKTIAGVHPIDEGVIEWEGKAVQIDKPHDAQNLGVATVYQDLALCDNIDVVGNLYLGRELRKFGILDEVEMERRSRELLSTLSIRIPSVRIPIASLSGGQRQTVAIARSMLGEPKLVILDEPTAALGVEQTAQVLDLVERLRERGHAVILISHNMADVKAVADKVAVLRLGRNNGVFDVKTTSQEEIISAITGATDNAVTRRAARNAEVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Z2</accession>
    <name>A0A7K2Z7Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_04040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000177">
        <property type="protein sequence ID" value="MYW28466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="244"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="36732" checksum="6FB76FAB5899769D" modified="2021-04-07" version="1" fragment="single">MTDPWVALAADTDPGERMGALRRAHEVFTSAGRLERPVRTVVGESWLRSARARVSPDGAPVVEFGADELGPYREAHPLARAMPVIRELMGAYATDGEHLLAVCDAHGRLLWVEGHAAARRRAGAMNFVEGARWAESVAGTNAPGTAIAVDRPVQVFAAEHFLRPVQQWTCAAAPLHDPHTGRVLGAVDITGGDRLAHPHSLAFVQAVARAAESQLALLAPAAADGGSVRLSALGRDEALLVAGDRRIRLSRRHSEILVALARRPEGLSGDELLIELYEDESVPAVTLRAELSRLRRLLGPDLLHSRPYRLGVPVDADFDTVARRLGSGAVAAALGAYAGPLLPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z838</accession>
    <name>A0A7K2Z838_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosamine-phosphate amidinotransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_04325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidinotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000196">
        <property type="protein sequence ID" value="MYW28514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015067">
        <property type="term" value="F:amidinotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033195">
        <property type="entry name" value="AmidinoTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10488">
        <property type="entry name" value="PTHR10488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633195-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="25456" checksum="3AB68BAFDAF09B6D" modified="2021-04-07" version="1">PMVLRSRFLEGFAYKELFLEYLESGARWLSAPKPQLTDAMYEPTAPPGERLRNLEPAFDAANVLRFGTDLLYQVSDSGNLLGARWLQAAVGDQYTVHPCEGLYTSTHIDSTIVPLRPGLMLVNPSRVNERNLPAFLRGWDRIVCPELTDTGYVGDHPRSSVWIGMNFLVIAPGKAIVDKRQTVLIRELERHGVEVIPAQLTHSRTLGGGFHCVTLDVRRRGELATYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z850</accession>
    <name>A0A7K2Z850_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Elongation factor Tu</fullName>
            <shortName evidence="6">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">tuf</name>
        <name evidence="9" type="ORF">GT040_04440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000199">
        <property type="protein sequence ID" value="MYW28537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="391" mass="41463" checksum="2DAB87FF47CDC84F" modified="2021-04-07" version="1">MSKTAYVRTKPHLNIGTMGHVDHGKTTLTAAITKVLSERGGSSTSYVSFDRIDRAPEEAQRGITINIAHVEYETDTRHYAHVDMPGHADYIKNMVTGAAQLDGAILVVSALDGIMPQTAEHVLLARQVGVDHIVVALNKADAGDPELTDLVELEVRELLTAHGYGGDTVPVVRVSGLRALEGDPRWTAAVEGLLDAVDTYVPIPVRYTDAPFLLSVENVLTITGRGTVVTGAVERGTVRVGDRVAVLGADIETVVTGLETFGKPMESAEAGDNVALLLRGVERDRVRRGHIVAAPGSVTPSRRFTAQVYVLSTKEGGRSTPVATGYRPQFYIRTADVVGDVDLGDTAVARPGDTVTMTVELGRDVPLESGLGFAIREGGRTVGAGTVTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z907</accession>
    <name>A0A7K2Z907_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NCS2 family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_05885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000257">
        <property type="protein sequence ID" value="MYW28813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="315" mass="32405" checksum="1A17878D9DFB4D60" modified="2021-04-07" version="1" fragment="single">MPPSATAPVDSPQPSAPQPTGGVDRFFKISERGSTVGRELRGGFATFFAMAYIIVLNPIILGSAKDMYGNQLDNGQLVTATVLSAAFSTLLMGVIGNVPIALAAGLGVNTVVALQLAPRMSWPDAMGMVVLAGIVVMLLVATGLRERVMNAVPRSLRKGIAIGIGLFILLIGLVDSGFVSRIPDAAMTTVPLQLGGDGHLTGWPILVFVLGALLTLALIVRKVPGAILISIIAMTVVALVIDAVAGLPEGAWGLTTPSWPGNPVSAPDFGLLGEVSLFGGFGKVGLLTGILFVFTVLLSCFFDAMGTILGVGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9B3</accession>
    <name>A0A7K2Z9B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile acid:sodium symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000298">
        <property type="protein sequence ID" value="MYW28923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="297" mass="31122" checksum="1682EA1CDE532BAD" modified="2021-04-07" version="1">MDSPVATVMLPLALAVIMFGLGLSLTADDFRRVRRHPRAVVVALVCQALLLPVVCFGLVIAFGLSPELAVGMMLLAASPGGTTANLFSHLFGGDVALNVTLTAMNAVVAVVTLPIIADLALLHFEPGIGEDGLGLQFGKVLQVFALVLVPVVIGLIVRRRSEAFARRMDRPVRNLSVVVLVAVIVGAVLAERENIVDYLVDAGPVALLFCVLSLATGYFVPRWARVGKRQAIACSMEIGVHNSAVAMTLAISVLGSVSLAVPAAVYGVLAYPVAALAGLMMTRLGNRRPVEEAVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9P4</accession>
    <name>A0A7K2Z9P4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_07205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000324">
        <property type="protein sequence ID" value="MYW29067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="26304" checksum="714A0EEC26FA4C69" modified="2021-04-07" version="1" fragment="single">MSSSSSTRHSPHRESRPRTTGAYRLVRTPPGSVEPPLLDAGQRAVVDHADGPLLVLAGPGTGKTTTLVESVAARVNRGADPARILVLTFSRKAAVELRDRMAARLGAARGPQATTFHSYCYALVRAHQDADLFADPLRLLSGPEQDVTVRDLLAGQLDLEKEGLAHVRWPDELRACLTTRGFADEVRAVLARSRELGLGPDALAAFARRTGRPDWSAAAQFLAEYLDVLDAQGVLDYAELVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Y1</accession>
    <name>A0A7K2Z9Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000349">
        <property type="protein sequence ID" value="MYW29112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="92" mass="9971" checksum="6650F35FD6A6F0C0" modified="2021-04-07" version="1" fragment="single">SRAGRGDFLQDRAVTVRVWRRGHRWWLLGAFVAAVASSFALPGAGGLVLAGAGAGLWAKAVRIGQRERRDDVLYWVRTDWAGRGSPVAKGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Z7</accession>
    <name>A0A7K2Z9Z7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000334">
        <property type="protein sequence ID" value="MYW29095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="333" mass="35170" checksum="80AF50BD2FBD8660" modified="2021-04-07" version="1" fragment="single">DRVRALDEEGATVRCDAGVALDRLLRILLSRGLFLPVVPGTGRVTVGGAIGSDVHGQDHPEAGSLARHVEALELLTADGEVRTVTPGTALFDATTGGLGLTGVILSATLRLKRVATPLVSVSTERATDLDDLLARFTAAGSDRTPYASAWIDLLARGRATGRGVLTRGEHAPPSALPAHAGRTMRAPRTVEPDRRPTGPLLPGGLLGRTATALLNEVRYRSAPRARTGELRTTAAFFHASDALPDANRLYGRAGLVRYRFTVGYGQEETLHRVVRRISARRCPAFRAGLQRFGSGGAGLLSFPAPGWTFAVDLPAALPGLARFLDGLDDEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA17</accession>
    <name>A0A7K2ZA17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntP family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000359">
        <property type="protein sequence ID" value="MYW29178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="491" mass="50454" checksum="E80C3AB2E8ECE076" modified="2021-04-07" version="1">MFLAATPPPVETPPHTGGLLLLIDGTAGLLTVAALGIALLLFLIIKVRLQPFVALLAVSIAVGLGAGLSVTELFGTVQKSAAVSVIESGMGGILGHVAIIIGLGTMLGAILEVSGGAEVLSARLLNAFGEKRAPLAMGMTGLVFGIPVFFDVGIFVLAPIVYAAAKRSGKSILLYAMPLLAGLSMTHAFLPPHPGPVAAAGLFNVSLGWVILMGVVVGIPSVIAAWVYAAWIGKRIFVDVPQDMVEAAEEAKAAVAAEQRAAGVTPHEKPVPLATVLAIIGTPLILILAATFSSIALDPSTLRSVVEFFGNPFVALTIALFLAYYLLGIRRGWSRKSLESVSTSSLKPVGNILLVVGAGGIFGAVLKGSGIADALADTFNDVGLPVILLAWLISVVLRVAQGSATVAIVTTAGIVVPLVEGQDLSQAHLALIIMAISAGSIFASHVNDGGFWMVSKYFGISERDTLKSWTVLETVLSVAGFVVAALLSLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA53</accession>
    <name>A0A7K2ZA53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000360">
        <property type="protein sequence ID" value="MYW29182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="43" mass="4259" checksum="3E1CDB25E72D7255" modified="2021-04-07" version="1" fragment="single">MASTAAAGTPAADASEAELMIGGMTCASCAARVEKKLNRMDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAI5</accession>
    <name>A0A7K2ZAI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_08810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000405">
        <property type="protein sequence ID" value="MYW29377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="360" mass="38375" checksum="FBCE8594CA3EC4B2" modified="2021-04-07" version="1">MITTTGLTKVYQSRDREVTAIDGVDLHVREGEIYGVIGQSGAGKSSLIRCVNLLERPTSGTVAVAGQDLTALAGRGRRASKELRAARTRIGMVFQHFNLLDSRTVLDNVELPLEILGVSGQERTRKAKELLDLVGLADKGKSYPKQLSGGQKQRVGIARALAGDPKVLLSDEATSALDPETTRSILQLLRDLNQQLGLTILLITHEMDVVKAICDSAALMQRGRIVESGTVGGLLATPGSELASELFPVGGTASGPDRTVVDVTFHGEAATQPVISQLSRTYNIDISILGAAMDTVGGKQIGRMRIELPGRFEENVVPIGFLREQGLQAEVVEDENGPRARAATTVPEQAPAAITKEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAJ6</accession>
    <name>A0A7K2ZAJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000384">
        <property type="protein sequence ID" value="MYW29285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="6959" checksum="6731B2A67E6C49B4" modified="2021-04-07" version="1">GDAGTVAAHVGELRAHAPQMVGGYLAMARATADRALAHGLLKPELAEDLLVALAGQESRPGSTGPGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAR0</accession>
    <name>A0A7K2ZAR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000408">
        <property type="protein sequence ID" value="MYW29392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="428" mass="47881" checksum="1AD475BDE7DEE809" modified="2021-04-07" version="1">MNKPSGRRRKDPAPRRLPARPRTLAVAAVLVVASTLGGYLVLSGTDDTTPTASATNRSERKPLSGASREPAWDGKVEVLGDGSTSYTGPQKGQLKPRPLKPGEKPPQFVVFSWDGALQGDDGLFAHYREMANRHDAHMTFFLTGIYLLPKAKKDLYDPPQHPRGSAAISFPTDEHVYTTLEQLAGAWKDGNEIGTHFNGHFCGAQGGGDWSVPEWKSEIDQFYSFVEKWKTNTGRTDLAPLPFDIRREVTGGRAPCLEGQANLLKAAKSYQWRYDASSAGDFQIWPQKKNGIWDFPLQMLPYEGGKYQGLSMDFNFLYNQSDGKTDGDPAMHPKWQQETLDTYTAGFNRVYYGSRAPLFIGNHFEEWNGGIYMKAVDRMIENVCTKKDVKCVSFKELADWMDVQKPATLERLRSLDPAQSPDWSTVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAW6</accession>
    <name>A0A7K2ZAW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000421">
        <property type="protein sequence ID" value="MYW29468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="23889" checksum="3BBB68F85175444C" modified="2021-04-07" version="1">MAGRGRPRAFDRDEALRKALGVFWERGYQATSMSDLTAAMGINSPSIYAAYGSKEKLFKEAVTLYTATEGRYTRRALDEQPTAREAVTVMLQENAAAYADPATPAGCLTVLAAPIPVRETSSVAVHLARMRAEVRDLIRQRVDRGIKDGDVRPDADAPAIALFYSAVLNGLSIQSRDGVALPGLQRTVDGAMAAWDTLAAPAVSSASASVASVAEPTGGTFGEPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAX2</accession>
    <name>A0A7K2ZAX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkaline shock response membrane anchor protein AmaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000434">
        <property type="protein sequence ID" value="MYW29500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="35" mass="3751" checksum="7420374520F1E147" modified="2021-04-07" version="1">VADGALAHARESAGLDELPAEVRLRAVKHRAERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBB2</accession>
    <name>A0A7K2ZBB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_10295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000470">
        <property type="protein sequence ID" value="MYW29657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="69"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="254"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="373" mass="39769" checksum="F5094869F7D22768" modified="2021-04-07" version="1" fragment="single">MSERTKTFAAVDLGASNGRVMVGRVGPGTLRLSEAHRFPNRPVHLPEGLRWDILGLYGGVLDGLRAAGQVDSLGVDSWAVDYGLLGADGALLGNPVHYRDRRTDAVAEKVWATVPPDELYRSTGIQHAPFNTLYQLVAAQGTPQLATARRLLLIPDLMTYWLTGEQGTELTNASTTQLIDPRTRDWARGPAARLSVDIGLFAPLRRAGDPAGVLLPHVLEATGLRGPVPVTTVASHDTASAVAAVPARPGERFAYLCTGTWSLAGLELDAPVTTEASRAANFTNELGVDGTIRFLRNIMGMWLLQECMRTWGESDIAPLLAEAAELPALRSVVDAADPVFLAPGSMPERIATACRATGQPAPATRAGTTRCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBM5</accession>
    <name>A0A7K2ZBM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_10745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000491">
        <property type="protein sequence ID" value="MYW29744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="273" mass="29492" checksum="16D2653DF1E1A4C1" modified="2021-04-07" version="1">MSKSRPNLLAGFGSVVWLLVVGLPLYVMLIATFQSRPDYAANGPLAFPAHFTLDNYIKDLNSGFAQYFLNTVVVTVCVVGIVVLLVPPLAYTIVRSRGRATTTVFRLFLLGLAIPSQAVIVPMFFVISQAGLYDNLIGVILPTAAFAMPVCALILTGVMRDITPDLYEAMTMDGASSRRVFFQLVLPLSRSGVATIIVFSALQAWNGFLFPLVLTQSAETKVITLGLYEFQTEHGVDTPGLLAAVVLSMLPILIVYLFARRALVQGLMGVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBN4</accession>
    <name>A0A7K2ZBN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="354" mass="38712" checksum="AECC7ADFF4EB3DC4" modified="2021-04-07" version="1">MITRGTGNLLLADVDALVNTVNTVGVMGKGIALQFKRAFPDNFSDYKASCERGEVTVGRMHVHDLHQVSNPRFIVNFPTKRHWRSSSRLEDIASGLVALRDEIVKRGIESIAVPPLGCGNGGLSWSDVEPMIRQTLGTIPGVEVRVWEPAGAPSPNSMPNVTPTPPMTKERAAFLATLDRYIRSGIARGLAFEPRVSLLEAHKVAYFLQKLQLPLGLSFEKGPYGPYSQPLDRAVSSMEGHFITGFGDGTSGAQAILELNKDSVHDAESVLRDYPNFKDVAASFDKLVSGFEDAFGMELLSTVLFAAQELVTPPPTPESVTECIQGWNSRKQRLFTESHVQTAWHRLSQAGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBV4</accession>
    <name>A0A7K2ZBV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_10985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000498">
        <property type="protein sequence ID" value="MYW29792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="167"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1065" mass="111067" checksum="EEFB7BEF5562E23A" modified="2021-04-07" version="1">MFAVDDPAPAPVKPAATSDRGDKLGKADAEILAKAEAKGEKNVTMMIATTPGATEQVTEQLDAVKGSVLGQTYDKLGYVRATVPTGTAEATIEAASKLKSVLGIDLKQEIKLDDPTPSGDRAAGAKQLKATGSYAAPGKNTPAANPYNPSFETGAVKFVEKNPTADGRGITIGVLDSGVDLGHPALKKTTTGERKIVDWVTATDPVSDGDGTWLQMSQTVTGPTFTAGGKTYSAPAGSYKFATFAESATTGGDMAGDLNRDGDTTDVWGVLYDPVKGTVRVDLNENADFSDDKALKPYKDKFQVEYFGEDDPATKVVERIPFVVETRKNVVYNAAGAKADYVNIGVIEGSHGTHVAGITAANGLFGGKMNGAAPGAKVVSSRACTWSGGCTNIALTEGMIDLVVNRGVDIVNMSIGGLPPLNDGNNARAELYKRLVDIYGVQLVISAGNSGPGLNTIGDPALADHVISVGASISKETWAANYGSNVTKKYDMLPFSSRGPREDGGFTPTISAPGASINTTQTWSEGGPVKEAGYALPPGYSMLQGTSMASPQAAGAAALLLSAAKQKDLELPPADLRTALTSSASHIKDVPAHVQGSGLIDIVGAWKLITKKGNPAHEYKVKAPVDTAIDFALKDPGFGTGLYDREGGLKVGETKVYEITVTRTTGPDRNVQHKLSWKNNDGTFKLSSPEYVSLPLDTPVKLKVTAKAKTAGVHSAILELDDNKTVGIDHQVLSTVVVAHELNHPGYAFKSSSSVQRNGTTSYFINVPEGAKTLEVALSALRSGSQTRFIALHPYGTPIDPTSTVNCYPNYENPANTCRPDVRSYKDPYPGVWEIEVESRRTSPLLDNPFKLDVSLLGASFDPAVQTIAEAKIGAPAAVNWKVTNSAAALEGKLKGGSLGSAKVDKPSISTGQTRQTTVTIGAGVEKLDFAIGGTSDANADLDLYVFRGATQVGSGTTAGSEEKVSLTNPAAGTYTVIVEGYSVPSGSTTYDYRDVYYAASLGTLKVDASKTYNLANGASAQVGAEVVVAGAAPEGRQFFGEVQLVNARGTAAGTGSVVIEKVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBZ8</accession>
    <name>A0A7K2ZBZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_11360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000515">
        <property type="protein sequence ID" value="MYW29863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="341" mass="35897" checksum="70C5D40D3B7F6B33" modified="2021-04-07" version="1" fragment="single">MRPVGSKYLLEEPLGRGATGTVWRARQRETAGAEAAVAGQPGETVAIKVLKEELANDADVVMRFLRERSVLLRLTHPNIVRTRDLVVEGDLLALVMDLIDGPDLHRYLRANGPLTPVAASLLTAQIADALAASHADGVVHRDLKPANVLLDERDGGMTPMLTDFGIARLADSPGLTRTHEFVGTPAYVAPESAEGRPQTSAVDIYGAGILLYELVTGRPPFAGGTALEVLHRHLSEEPRRPSTVPEPLWTVIERCLRKDPDQRPSAENLARGLRTVAAGIGVHANSAQIAAADGVGALLAPDPAPTAVPETPGAADPTQVLPSNAGSYDPGAATSVLPQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCD8</accession>
    <name>A0A7K2ZCD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000560">
        <property type="protein sequence ID" value="MYW30027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030567455.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000560.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="101" mass="10911" checksum="CAAE0A61DA45B20E" modified="2021-04-07" version="1">MEPTEFPPLPALTRAEGELIDCYLAVLDQVGRINPARGSDTYSALRAAQALVSRAAALRDALSLMHERGERQIHAATLARALRVLDGERRAGRVAVPPTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCJ5</accession>
    <name>A0A7K2ZCJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000569">
        <property type="protein sequence ID" value="MYW30053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="30731" checksum="DC23BC973D5BCC94" modified="2021-04-07" version="1" fragment="single">RTGTGSGTGGDEPWTQHAEGVLAPGGPASPADGDTRAPAGVLEVDLTGVYDRLAGQDYRYGPAFQNLRRLSRLGDDLYAEVAAGAEHPAGGAGFTLDPALLDAVLHALLPGVAGVADRPMVPFSWSGVSVPAGPVDALRARLTLRKSDDTAVAVGLTLTDGAGLPVATVEELLLRPLSPDDLPVAGDRAAEGLFGLSWEPVPLDRTTAADEDRVVLGGTLDLPEARTHADLAALRRAVDDGEATPSAVLLPLEAPAGTGGLAERARAALAGVLATVREWLADERFADTRLAMVTRGAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCQ0</accession>
    <name>A0A7K2ZCQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15557" checksum="399F41B81B04B874" modified="2021-04-07" version="1">MSEIFVLEGIEFDLTLTYADITGVEWAWTGEHVDGVPLMAQKRAPGGCDTPWKLTDLYWELGPLIAIHDRPSPADFRAAIDPDYADTVAAGYVEAPAAFGARITTAPVPNSAVPQLTAHHLPPSPLEQTGFRGFLNTIKGARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCU7</accession>
    <name>A0A7K2ZCU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000601">
        <property type="protein sequence ID" value="MYW30163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016516">
        <property type="entry name" value="UCP07580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39456">
        <property type="entry name" value="PTHR39456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10118">
        <property type="entry name" value="Metal_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007580">
        <property type="entry name" value="UCP07580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="301" mass="33945" checksum="711EF858126A3658" modified="2021-04-07" version="1">MSNTQPAAVASERTPLKARKVSFAWEKTPLHWVPGDPFTTHTINVLHLLLPAGERWFIHVYRQILPYIHDEQLREDVIGFIGQEAVHSQAHDDVLPHMRELGLDPTPYTAQVDWFFEKLLGDRTLPPGRPSQWWLMERVAMIAAIEHYTAFLGDWILNAEALDHKGADPTMLDLLRWHGAEEVEHRSVAFEVFMHVDGGYRRRVRTWAAAFSALVFLWQRGIRFFMENDPSLLNGKASFKAFHASGKEGTLPSTGAILRSIPSYLSRSYHPSQEGSTAQAVDYLAHSPAALAAEARTTGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD19</accession>
    <name>A0A7K2ZD19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000617">
        <property type="protein sequence ID" value="MYW30246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="14958" checksum="23279198F6320242" modified="2021-04-07" version="1">VPGERAEIGLPRDLAWARAVGSLDAGLAVAVDYAHLRGARPPFGTLTGFRGGREVLPVPDGSCDLTAHVALDACAAAVDRGAAELTGQRAALGRLGVSGERPPLSLAATDPAAYVTALAAAGEAAELTARGGLGDFGWLLHRVGAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD28</accession>
    <name>A0A7K2ZD28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000609">
        <property type="protein sequence ID" value="MYW30208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="20413" checksum="0D11BF805250AF5C" modified="2021-04-07" version="1">MLLAGEEWAARFASFQREAWRLETLPQYLMPQEAEEFESFKGGARIDPATVSNEYTERLRRQVAQGRSQGRVHVLARPLSDYLRFEFHHYYKAHSLAGEEIRILDVTDRPNPLEDVQDFWLFDASEVVLMNYHSDGRQISREVFNGDVRPFLEHQRIAVEESVAFEEYVKGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD35</accession>
    <name>A0A7K2ZD35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="15" type="ORF">GT040_13455</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000629">
        <property type="protein sequence ID" value="MYW30267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513060.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000629.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5029992069" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029992070" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW30267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="14573" checksum="2EDA14066D7D4999" modified="2021-04-07" version="1">MFRTMFKSKIHRATVTQADLHYVGSLTIDEDLMDAADLLPGEQVQIVDITNGARLETYVISGERGSGIIGINGAAARLVQPGDLVIIISYASVADAEAKALVPSVVHVDQHNRQVSLTGSDLAEPAPGSGTVRGDLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD55</accession>
    <name>A0A7K2ZD55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000620">
        <property type="protein sequence ID" value="MYW30249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="51" mass="5785" checksum="1DAEA8220755952F" modified="2021-04-07" version="1">LDTSRGGRRRWCSGEVCGNRERVARHRRRTASSSAATTADEKPRRISTKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDX3</accession>
    <name>A0A7K2ZDX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000709">
        <property type="protein sequence ID" value="MYW30518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="8551" checksum="852EAAAE86DFA322" modified="2021-04-07" version="1" fragment="single">FGGGRGAGAAAIALIGSGVGACVDHGDILAEDRTSLALEWGHTTIQLRGRRCRCGSIGCLEAYAGAEALRERWREAGGPLPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEC2</accession>
    <name>A0A7K2ZEC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000735">
        <property type="protein sequence ID" value="MYW30707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8029" checksum="93B9864506488777" modified="2021-04-07" version="1">MTTTPSGAGDRLVSVGAIVFFIGALATLVTVAPLFLGTEPFPPIAYGVSMFMGLGFLIAGAGVVRSVWLSSPKRAASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZED1</accession>
    <name>A0A7K2ZED1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000736">
        <property type="protein sequence ID" value="MYW30713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029513862" evidence="3">
        <location>
            <begin position="24"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="21846" checksum="B91E501E41529400" modified="2021-04-07" version="1">MSSPSPAMPTAASVPSPAAPAIAAAPVAAAPAVSARVGSARAVSAGPTVAELLDFVRRTAEDEALIASLPLDPEGRTWVRLDGPGGSEAWLIGWPPGAGTGWHDHADSVGAFTTASGTLKEHSLAVRLPTDGWKTLELNEGVDRTRELAAGQGRAFGQNHVHEVLNESDSVHAVSVHAYYPPLPRIRRFSRTGAVLRLEQTESPEDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZED2</accession>
    <name>A0A7K2ZED2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Xylulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_15855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000737">
        <property type="protein sequence ID" value="MYW30714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="8321" checksum="80F9DBDB9D08DACE" modified="2021-04-07" version="1">SWVETVRRLSGRPVVIPAGGELVALGAAALAASAAGGGDPVALATSWGAGDTGSQLDPVERDLETWQRVTSVLDRAAEPLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEN0</accession>
    <name>A0A7K2ZEN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF427 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000766">
        <property type="protein sequence ID" value="MYW30827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="12374" checksum="A2906B5BB69C3656" modified="2021-04-07" version="1">MTSTRGHHITVEPGTVHVRAVHEGQVLAESRRPLILRETGCPDRYYLPPEDVRTELLTPSDTTTHCPFKGDASYWSLPGAADLVWAYPEPKPEVAAIQDHFCFYGTEPVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEU2</accession>
    <name>A0A7K2ZEU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SulP family inorganic anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_16480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000767">
        <property type="protein sequence ID" value="MYW30829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="280" mass="29690" checksum="CB1A01CE09E76F52" modified="2021-04-07" version="1">ALAGLRPLVADVNGLLHAIDLPGAAEFGNLANVAVIGTVLAFALIASAESLFSAAAIDRMHDGPRTDYDKELVAQGVGNTICGALGALPMTAVIVRSAANVQAGATTALSRVAHGLWLLLFAALLPAAIGIIPLASLAGILVHAGCKLVPFREFGPLWREHRREAVLLAVTALAIVVTNLFEGVVLGLLLAVVKSAWETSHVQLSTRQLTGGRVVVTLTGNATFLRLPRILEQLEKLPQDQPIELDLSGLRHLDHACRVALENWARRHNDAETDPVTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFD1</accession>
    <name>A0A7K2ZFD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000822">
        <property type="protein sequence ID" value="MYW31042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030573537.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000822.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16396" checksum="03CBF8F68D39226E" modified="2021-04-07" version="1">MSKAKNLQTGHIGLNVTDLDRSIAFYREVFDFELLGEGKDGDRRWAFLGRDSRLVVTLWQQSEGAFAPALPGLHHLSFQVDTVEEIRATEEVLRSLGATFAYDGVVPHGETGTSGGIFFTDPDGIRLEIYASTGADPADAPTSNAPTCGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFH3</accession>
    <name>A0A7K2ZFH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan DD-metalloendopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_17770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000837">
        <property type="protein sequence ID" value="MYW31080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029687970" evidence="3">
        <location>
            <begin position="45"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="4">
        <location>
            <begin position="163"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="237" mass="23768" checksum="26964143EA42DAF2" modified="2021-04-07" version="1" fragment="single">MAFTRATGKHRAPSRLTRRSAQAAGIAALATTGVLGSLASPAAAADSEAPKAAETGLTQAIALDATLAEQIDAQARAQHQQAEAVAKAKAKAAAEAKAKAAKAKAKAEAQRKAEARAKEIREEKARAARAAERARLNAFHLPVAGSSVTTGYKSGGALWSSGSHSGVDFRAASGSSVVAVGAGTVIEAGWGGAYGNNIVLRMTDGTYTQYGHLSSIGVSVGQSVTSGQQIGLSGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFV3</accession>
    <name>A0A7K2ZFV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000863">
        <property type="protein sequence ID" value="MYW31198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="20716" checksum="A1F5E34F8401C4F1" modified="2021-04-07" version="1">MSTTTTAEHSTRNTTLARTVTDVLQPRNALLAGMLGIGLAAAGDWTGLLWGFLGALCAGLIPAGYIEWERGRGTWGDRHVVDRTKRAPIFFVILGSIGAGSVVMVLGNAPGGILVAMLALWVMTIGLLAVNTVWKISVDSAVASAVVALLAVVHSPWWLAAYALTVAVCWSRVALGYHTVAQTVAGAALGAATTVAYAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG11</accession>
    <name>A0A7K2ZG11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000874">
        <property type="protein sequence ID" value="MYW31270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26077" checksum="9A616DC21ABB1DE1" modified="2021-04-07" version="1">MTSQLFAICFRATRPSDLARFWSGVLGWEVAGGPDEDAVAILPPDGSGFRIRFLPGQEPKIGQNRAHFDLTSASPEDQRRTVARALEHGGRHIDVGQLPEEGHVVLADPDGNEFCVIEPGNKFLADTGFIGALACDGTQEVGYFWSEALRWPLVWDQDEETAIQSPDGGTKITWGGPPVAPKTGANRLSFELALPSGTDWQAEAGRLVSLGATRSEAGEGDGEGGRVLMFDPDGNEFFVQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG50</accession>
    <name>A0A7K2ZG50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_18810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000873">
        <property type="protein sequence ID" value="MYW31269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="21119" checksum="AB5ABBE3AE433B6E" modified="2021-04-07" version="1">LREARWERARIGAALELAPADLVTVSYVLKELPPEARTGLVDAAAAAGQAVVIVEPGTPDGYVRIIEARDRLIAAGLSIAAPCPHDDACPIAPGTDWCHFSARVSRSSLHRQVKGGSLSHEDEKFSYVVATRFPATPAPARITRKPQLRKGQVLLELCTRDEGLSRSTVTKRHGELYRAARDIAWGDPWPPEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGC5</accession>
    <name>A0A7K2ZGC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF262 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000906">
        <property type="protein sequence ID" value="MYW31355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030730788.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000906.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="2">
        <location>
            <begin position="104"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="431" mass="48677" checksum="D11FC7A94EC75926" modified="2021-04-07" version="1">MAVDEDGEDRAGVESGRTPGTRGYALADDVDQPDSLFLPLGPPIEIGSDGRPTGVELELPADEEGEEHGAHRDAGDASAPFRPDNIRIHTETTTVDLLLSRLREGMIDLAPDFQRRSGIWSDRAQSRLIESLLLRIPISNFHMAQGDEDRWAVVDGVQRLTAIARFMEPEITGLEPLTLRGMDYLWQLAGSTYQDLTGRMRIRLRETQLTVHIMQQGTPEKVKYNVFTRINTGGMPLTPQELRHALVGGEVRTFLADLAEEPSFGEATRWSVSDARMADREMVLRFLAFRLTNPSRHSETDFNKFLIDSMYRINALSDERRDQLAREFRTAMRCARELFGEHAFRKWQGGERSSPVINKALFETISVQLALLDDDERARLVASRPAVHDQFFRLLGEWDFDRSISVGTGSPARIRTRFQEVARLFRGVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGD6</accession>
    <name>A0A7K2ZGD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_19515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000911">
        <property type="protein sequence ID" value="MYW31402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="263"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="352" mass="38242" checksum="16F28BB0CE7FD4B2" modified="2021-04-07" version="1">MFHPLRVSAIERITDDAVAVTFAVPAELREIFRHAPGQHLNVRYSVDGKEIRRSYSICAPATEQPADPVVRVGIRGVEGGAFSTYALKELSVGDQVEAMPPMGRFVLEPRPGLFAAVVGGSGITPVLSMAATLLAREEKARFCLIRSDRTAASTMFLDEVADLKDRYPDRFQLITALSREEQSAGLPSGRLDTERLTALLPAVLPVAEVDGWFLCGPLGLVRGTEKALRALDVDRTRVHQEIFHVDDGPSDVTVVKVAAPSDATLTATLHGRSGSWPVQDTESLLETVLRSRSDAPYACKGGVCGTCRAFLVSGEVRMERNFALEPEETDAGFVLACQSHPLTPEVELDFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGF8</accession>
    <name>A0A7K2ZGF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysozyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_19765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000922">
        <property type="protein sequence ID" value="MYW31451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029663927" evidence="5">
        <location>
            <begin position="39"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="30415" checksum="F9289A7488908173" modified="2021-04-07" version="1">MPLHRHRSGISRRSRLTTGGTLLAALTLLLTLPGAAPAAGPDTADAPPARGTARMGQGVIEHDGQGGPPRDTRVVQTEGVDVSSHQSDVAWPTLWNSGVKWAYAKATEGTYYKNPYFAQQYNGSYNVGMIRGAYHFATPNTASGAAQANYFVDNGGGWSRDGRTLPGVLDIEWNPYGAQCYGLSQAGMVNWIRDFTSTYRARTGRDAVIYTATSWWKDCTGNNAGFGAVNPLWVARYNTTVGELPAGWPVHTMWQYTSTGPTVGDHNRFNGALDRVQALANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGR9</accession>
    <name>A0A7K2ZGR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000947">
        <property type="protein sequence ID" value="MYW31536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="183" mass="19484" checksum="4662A2F613F76C4D" modified="2021-04-07" version="1" fragment="single">MPHRVAVLALDGLLPFELGIPARIFGRSLDPAPGNKGGKLYEIVTCSVRPPGPVRTDSDYAILVEHGPEALATADTVVIPASYELGPVFEEGRLTEELAAALALVRPGTRMVSICTGSYVLAAAGYLDGRPATTHWSSADHFQRLFPQVRVDPDVLFIDDGDVLTSAGVAAGIDLCLHLVRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGT3</accession>
    <name>A0A7K2ZGT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000960">
        <property type="protein sequence ID" value="MYW31552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7092" checksum="4E6EF60815F38989" modified="2021-04-07" version="1" fragment="single">ERGSELHVPAARCLSAVAGPEDRPQIIEAARDGAEGARCAALHYLAEAADPAVLDLIETAALSPSRTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI07</accession>
    <name>A0A7K2ZI07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RecQ family ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_22075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001039">
        <property type="protein sequence ID" value="MYW31889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="39"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="244"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="635" mass="68271" checksum="A296ADA513C76E05" modified="2021-04-07" version="1" fragment="single">MTNADRAALRASADSVLARLVGDATGEARLREDQWLAIEALVADKRRALVVQRTGWGKSAVYFVATSLLRAQGSGPTVIVSPLLALMRNQVAAAARAGISARTINSSNTEEWESVQAEVVAGEVDVLLVSPERLNNPDFRDQVLPRLSAATGLLVVDEAHCISDWGHDFRPDYRRLRTMLADLPTGVPVLATTATANARVTADVAEQLGTGAGTDALVLRGPLDRESLSLSVLQLPNAAHRLAWLGDHLGELPGSGIIYTLTVAAAEEVTAYLRQNGHPVTSYTGRTENADRQQAEDDLLANRVKALVATSALGMGFDKPDLGFVVHLGSPSSPIAYYQQVGRAGRGVEHAEVLLLPGKEDEAIWQYFASVAFPPEEQVRRTLDVLARSERPLSLPALEPLVDLRRTRLETMLKVLDVDGAVKRVKGGWISTGEPWVYDSERYAWVARQRAAEQQAMRDYATTTACRMEFLRLRLDDEEATACGRCDNCAGARFDDKVSTAALDGARSELGRPGVEVAPRKMWPTGLSAVGVDLKGRIPAGELSSAGRALGRLSDIGWGNRLRPMLAAQAPDAPVPDDVTDAVVTVLTDWARGPGGWASGAPDAAPRPVGVVTVASRRRPQLVESLGRRIAEIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI12</accession>
    <name>A0A7K2ZI12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripartite tricarboxylate transporter TctB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001063">
        <property type="protein sequence ID" value="MYW31977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009936">
        <property type="entry name" value="DUF1468"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07331">
        <property type="entry name" value="TctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="21278" checksum="3464761567331A90" modified="2021-04-07" version="1">MGPAEPTGPIGPAEPTGPTGPAEPTGPTGPAEPTGPTQEQDKDTTRSWLRDHSELGVCALLLAIGALVLTDALTMSVDIAQRGPIGPRTVPFVVGSALLLVAVLLAVDVLRGGRGEAEGGEDVDLDEPADWRTVLLLSGVFLAAAVLIGPLGFPIAGALLFWGSAYALGSRHHDRDPLIAAVLSLATYFLFDNLLGVPLPGGPLMGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI17</accession>
    <name>A0A7K2ZI17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001043">
        <property type="protein sequence ID" value="MYW31899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="297" mass="33682" checksum="B0DA11C44E0F54E9" modified="2021-04-07" version="1">MTTMAAEPLLAADSTESPSEMRRHELAAFLRSRRERITPEQVGLVRGRRRRTPGLRREEVAQLSAVGVTWYTWLEQARDIQVSAQVLDALARALLLDPSERAHLFALAAAPDPAPGTECPTVTPALRTMLEQLDPIPACVQNSRYDVLAYNRTYSRLLCDLDALPPEDRNCLLLAFTHDDWRASIVDLPEVTRMMAAKFRASMAGHLAEPAWKALLHRLETRSPEFREVWERHEVVDQKGRTKYIRNARVGLLHVEHTNLWLGPASGPRLVSYPPVDEETRTRLERLHRIALAAEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI48</accession>
    <name>A0A7K2ZI48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001066">
        <property type="protein sequence ID" value="MYW32014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="15713" checksum="9079317632C4BF42" modified="2021-04-07" version="1">MRLTRFTDVALRVLMRLAVAEGADPPTTREVADTMRVPYAHTAKVVARLQHLGLLDARRGRGGGLTLTTAGHSASVGALVRELEDTDDVVECEGDTPCPLRSDCRLRGALRQAQEVFYASLDPITVTDLVASPTGPLLLGIGSGPPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ97</accession>
    <name>A0A7K2ZJ97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lantibiotic biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001159">
        <property type="protein sequence ID" value="MYW32404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="1">
        <location>
            <begin position="12"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="353" mass="39792" checksum="E924AF1244CAB0B0" modified="2021-04-07" version="1">MTPLTAEMTGAWQATHVFYAANPRPFLLHCVRPLVAELEADGLLAGYFFINYWLEGPHVRLRLKPSSPAAEPEVARRTEQAVDAFLAERPALYEVDSGFLNDFYNTLFDIEFPGSERGHYMDEQGRMNLRPNNSRHREAYEPEFGKYGGPAGIELAEWHFRHSSDLVIDALATKNLHLRTVLLGTSAQLMMVMASTFLPERAELTEYLDSYYAFWHRAFPGTGFIGTDEYDRNYARTADGLRDRFTRIRAATAPPGSARSLPGSLAGWAEHCAELRHRARKLAVDGDLVFRSWDGERDEQVTDPAVALPLLLSPYLHMTNNRLHVTIRDEAYLSHVLGRVLKESAEGHAEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJB0</accession>
    <name>A0A7K2ZJB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rne/Rng family ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_24975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001168">
        <property type="protein sequence ID" value="MYW32433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="212"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="668" mass="74074" checksum="18C50425B92846CE" modified="2021-04-07" version="1" fragment="single">APEAEADEHEDTDEYGDRPSRRRRRGGRRRRRGEANDTDEAEQHADEAPAPSRSEDDQAPAPVQEADEEDDDNDSAASGSSSSRRRRRRRRRSGEGGSEADNGTDDPERTVVKVREPRKKEEREPGTGFDEVQSIKGSTRMEAKKQRRREGREQGRRRVPIITEAEFLARREAVERVMVVRQSGERTQIGVLEDNVLVEHYVNKEQATSYVGNVYLGKVQNVLPSMEAAFVDIGKGRNAVLYAGEVNFEALGMAHGPRRIETALKSGQSVLVQVTKDPIGHKGARLTSQVSLPGRYLVYVPEGSMTGISRKLPDTERSRLKTILKKIVPEDAGVIVRTAAEGASEDELRRDVERLQQQWEEIQKKAKGTSGSNAPTLLYGEPDMTVRVVRDIFNEDFSKVIVSGDDAWETIHGYVSHVAPDLTERLSRWTSEVDVFATYRIDEQLMKALDRKVYLPSGGSLVIDKTEAMVVVDVNTGKFTGQGGNLEETVTRNNLEAAEEIVRQLRLRDLGGIVVVDFIDMVLESNRDLVLRRLLECLGRDRTKHQVAEVTSLGLVQMTRKRVGQGLLESFSETCVHCNGRGVIVHMEQPTSVGGGGGSKKSKKRRGGAGQDHEHGHEQDHGHEHGHDDHAAEPVETESEAELAAEVAAPVSLADLEPAADEEFYSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJD1</accession>
    <name>A0A7K2ZJD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18370</name>
        <name evidence="4" type="ORF">GT040_25035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000861">
        <property type="protein sequence ID" value="MYW31185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001174">
        <property type="protein sequence ID" value="MYW32445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033912525" evidence="2">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="15103" checksum="2D501EF0C8CC8E85" modified="2021-04-07" version="1">MRKFACTIASAVMVSGLLGAGVAQASTPAAERPIEAKATKKFDTPLYPNRKSESSQKFKKGKTGKVKYTVTKKGWNHAVGFRLVTCKGHKGLTEWIDFKKKKGDYYTFKKSVKKGTCFKVQAGRSWAQSAEGKVKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJM5</accession>
    <name>A0A7K2ZJM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001198">
        <property type="protein sequence ID" value="MYW32560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="17645" checksum="78333135441029B9" modified="2021-04-07" version="1">MPLLSYRLDESHLVVELRDVVDHDNEAAIEQELLTLVPCCGPSTVIVDIVTPLLTPRALGVLLRVRADAEQRGVSIAVVARYETAREVLGAASLNRVLRVAYSLQGAELRSRGCRPGASAPRREGLLEWLERRITPSDPAPPPARAVGPYADTSVPRVPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJZ8</accession>
    <name>A0A7K2ZJZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001218">
        <property type="protein sequence ID" value="MYW32670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="43" mass="4672" checksum="E6C30CDC5A10DE15" modified="2021-04-07" version="1">EENWRRIDAGESADAVYAGAVQAAEEAFVQLRRGLEPQGRGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK01</accession>
    <name>A0A7K2ZK01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_26225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001220">
        <property type="protein sequence ID" value="MYW32674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="913"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="883"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="948"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="974" mass="101985" checksum="91C4D283FF31F0CE" modified="2021-04-07" version="1" fragment="single">QPVLCSRVDPDGPALVPAAGPAPVLRRLSCAPGELDALLVEESTRPFDLTGGPLVRFALVTAGDGPRVLHVVVHHLVFDGSSKDVLLAEILGTETWPGPPDVRVDAAEPDDQQVSRAREFWADRWHDPAPPALPGLAASVRDTTAPAPGAAHGFTLGPALDTRLTGTAEALGVTRFELLLTLWHTLLLRYGNQAPVTALELSTRLPGSPERIGLYVNELPLFTHPDPDRPFADFAQEVRTELRAVYGHRPVPLGRAVSGLTPRTALAPLSVSYRRRTGWETDEAPGSEIDWIGLTHAVRNLAHLQLVDGPQGLEGSFQYRTDAFAPGAPARIVGHFRTLLDAVLTAPGATEAPLCALPLLGGEELAAALHPGDERPAACPADATVVSMFTDRVAEDPAAVAVVTADGVELSYGELHAAVAVFADRLAEAGLGAGDLVGVEVSRSVHELIAVLGVLTAGAAYVPLDPGYPAERLEFIRADAGLAALVIEGPAPDGLPAGLPVLFPGEPEGPKAPRASAGVRTTAPAAGDPAYVIYTSGSTGRPKGVEIPHRALANLLATMADHIGAGPRDRWLGLTSLSFDISTVELLLPLTTGARVVLVPEGRQRDGGALLKLIDSHAVTHVQATPSSWRLMLAAGLDRPDLVAIAGGEALPGPLADELTGACARLVNVYGPTETTVWSTLAHLTTGAPVTIGRPLAATRAYVLDARGEPVPDHLLGELHLGGAGVAHGYRGRPGLTARCFVPDPWGPPGSRLYRTGDLVRRLPDGRLEFVGRPDSQVKLRGHRIELGEIEARLVGHARVSQAVVVLDDGTGEGEARLVAYVVGAPEPAAGHIAGKPEPSAAYLVGAPEAPAAEELRRLLAHTLPAAMVPAVVVPLPELPLTPNGKVDRARLPEPPRVRPDGPPAPAAPAATVAEGSAAAVVREIWQEVLRLDDIGPDEDLFDLGGHSLTITAIAARIRKRLGVEVPLDVFFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK34</accession>
    <name>A0A7K2ZK34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001203">
        <property type="protein sequence ID" value="MYW32609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11575" checksum="8A734FED523D52BA" modified="2021-04-07" version="1">MARKDRTPEAAEEKAREKWMARFQVRLAMQPGVDRAVVLQAVKEVTTHCADTGESPQTAYGDPDAHAVRTAERLVPADVAARAKRHDAAVDKLGSALKRARDITGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKI2</accession>
    <name>A0A7K2ZKI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ketoacyl-ACP synthase II</fullName>
            <ecNumber evidence="5">2.3.1.179</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_27220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001265">
        <property type="protein sequence ID" value="MYW32864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="5"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="421" mass="44200" checksum="8A1AE9F417BF309A" modified="2021-04-07" version="1">MARRVVITGVGVLAPGGLGVRDFWSLLSQGRTATRRITRFDPSPFRSQVAAEIDFVPAAHGLDPQESERMGRAAQFGVVAAREALADSGVAQALAPQRTGVVMGTAGGAVAGLDAAYRSMSDERRPADVDPAHAPPWLYDHFVPSSFATEVAWAVGAEGPSAVIANGCTAGIDAVAHAVELIRENSADVMVAGATDAPITPVVMAAFDAVRATTTHNDEPATASRPFDDSRDGFVLGEGAAVFVLEELHHARGRGAHMYAEVAGHASRSNAFHMTGLHPEGRELAEAVRAALDEARLDPRDLDYVNAHGSGTKLNDRHETQAYKLALGEHAHRVPVSSVKSMIGHAMGSVGAIEIAASVLAMEHHVVPPTANLHVPGPGCDLDYVPRVAREQRTDAVLTVGSGFGGFQSAMVLTRHDRSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKM1</accession>
    <name>A0A7K2ZKM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001269">
        <property type="protein sequence ID" value="MYW32878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030563397.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001269.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15466" checksum="BD94218B0BF598FF" modified="2021-04-07" version="1">MATAPISGTNAAPVRGRSTRQRAAVAAALDEVDEFRSAQELHDVLKHRGDSVGLTTVYRTLQSLADAGEVDVLRTTEGEAVYRRCSTGDHHHHLVCRLCGKAVEVEGPAVEQWAEMIAAQHGYVNVAHTVEIFGTCAECAASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL41</accession>
    <name>A0A7K2ZL41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnhA</name>
        <name evidence="8" type="ORF">GT040_28325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="235" mass="24532" checksum="D006C5422B623EA3" modified="2021-04-07" version="1">MNESIIAACDGASKGNPGPAAWAWVVADAQGNPQRWEAGPLGTATNNVAELTALAELLESTDPAVRVEVRMDSQYAMNAVTKWLPGWKRNGWKTSAGKQVANRELVTRIDALLTARTVTFRYVPAHQVDGDPLNALADQAASEAAVAQRPAGTAHGATALPVPAQTRATKGRTEAGDGAGEAKGAKSASRTGRSNGTIKARFAGRCHCGRTYAAKEPIAKNPSGWGHPECRTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLC4</accession>
    <name>A0A7K2ZLC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001341">
        <property type="protein sequence ID" value="MYW33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045931">
        <property type="entry name" value="DUF6350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19877">
        <property type="entry name" value="DUF6350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="10337" checksum="62C003172ED89FFF" modified="2021-04-07" version="1" fragment="single">MTERSPMLPPERTRTLALASAFLRGVAAAGLGLGSLAVLVTVLWISSPYPDSGPGGALRAAAAVWLLAHGAELVRPDTLSGVPAPVGVVPLLLVAGPVWLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLW6</accession>
    <name>A0A7K2ZLW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029821503" evidence="1">
        <location>
            <begin position="28"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="30909" checksum="98DC8CA05188AA13" modified="2021-04-07" version="1">MRTSTLRRVGTGAVLAALLSVTACSGGDGGSGTAGKPTGAGVADAGSVTELQQIRKRTGTVRSARIEGTTEMGATVSMKQTGTIGWADGLTGSLTLTYTGGTMAKALKQGGADGSVRARYLQDEYYADMGEAFASTIGGKRWVRYAYQDLAELGGPAGDVLEEQVQNSTPEQGLKALLAAGDVRKAGQEDVRGVPATRYSGTVDVAELTGRNSALEAGQLAALKERLSAAGVTTQTVDIWVGEDGLPLKKTERGETAAGVFSSTVFYSDYGTEVSVRKPPAADTVDFKEILRQRAAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLX3</accession>
    <name>A0A7K2ZLX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001384">
        <property type="protein sequence ID" value="MYW33365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7231" checksum="B970FFF3C7FAAEBC" modified="2021-04-07" version="1" fragment="single">AEVAAEAEAALVAAVSVPEQPAARDEQRRDERGNYERRDNRGGDRGGYRGGNDRRDDRPSGGFRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLY6</accession>
    <name>A0A7K2ZLY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Signal peptidase I</fullName>
            <ecNumber evidence="3 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lepB</name>
        <name evidence="9" type="ORF">GT040_29455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 6"/>
    <dbReference type="EMBL" id="WWKE01001362">
        <property type="protein sequence ID" value="MYW33279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="8">
        <location>
            <begin position="42"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="257" mass="27450" checksum="175DAF00145B4B45" modified="2021-04-07" version="1">MDTQAEHSERDRSSEPHTGSEERSRFSRVRGAVATVRPWRRRVLVAGVAGTAALLLFSAFVVQPFLIPSGSMEPTLQVGDRVLVNKLAYRSGAEPRRGDVVVFDGTGSFVREDLDANPLAAPVRWAASSLGLADPPDTDFVKRVVGVGGDRVVCCDARGRLRVNGVPVDETYLHPGDTASEAPFDIVVPQGTLWVLGDHRSRSSDSRDHLGSPGGGMVPVERVIGRVDWLGWPPTRIGGLEGTDAFDGVRAPGGAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLZ5</accession>
    <name>A0A7K2ZLZ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hisF</name>
        <name evidence="11" type="ORF">GT040_29960</name>
        <name evidence="12" type="ORF">GT040_39490</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01001386">
        <property type="protein sequence ID" value="MYW33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001789">
        <property type="protein sequence ID" value="MYW35200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW35200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="26636" checksum="D6A123AD1D8AD7DB" modified="2021-04-07" version="1">MTLAVRVIPCLDVDNGRVVKGVNFQNLRDAGDPVEMAKLYDAEGADELTFLDITASSGDRETTYDVVRRTAEQVFIPLTVGGGVRTPDDVDKLLRAGADKVGVNTAAIARPDLIREIAERFGRQVLVLSVDARRTPEGTFEVTTHGGRKGTGIDAVEWAHRAAELGAGEILLNSMDADGTKDGYDTEMIEAVRGHVTVPVIASGGAGRLADFAPAIEAGADAVLAASVFHFGDLRISQVKDALREAGQPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM75</accession>
    <name>A0A7K2ZM75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_30395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001398">
        <property type="protein sequence ID" value="MYW33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="36506" checksum="1FAD1C173D50CFE4" modified="2021-04-07" version="1">MSQLPKQPAEVSVPTSADVARLAGVSRATVSYVLNNNATVRISEPTRHRVREAATHLGYVPHAAARSLRAGHSRLVLLPSGHIPAGPLHQHFFQELQAGLRRLDYTVVQYGSAGLADDEAVTAWAELRPVAVVVPPGITLTPHGTEILTRSGAKAVITLGPEPVEGAHGLVMDQRQVGASAVGHLLARGRRRIGVVMPREEGLTPFSEPRLAGARRTAEPAGAHISPLPLHYEEESAAELAHRWPELGLDAVFAYNDEYAMLLMRALQDAGVAIPGDTAVVGADDLLLGRLLRPRLSTVRMELAMPDPLAETIDRLVHHPGTAPVHHDLLRTSAVHRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM98</accession>
    <name>A0A7K2ZM98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001406">
        <property type="protein sequence ID" value="MYW33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="86" mass="9085" checksum="02BB1BE56504F479" modified="2021-04-07" version="1">TALRDKAIRPFLLGELAEAGRAAAPGGPRFTPPAFAGPDYTRPDYTTRPDFTGPDFTRPDFTGPDFSGPGHGSPGTGSPQLPDTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMB2</accession>
    <name>A0A7K2ZMB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001409">
        <property type="protein sequence ID" value="MYW33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="11239" checksum="C4526EF666572451" modified="2021-04-07" version="1">GPLCGCGGRGCIEALCLAAEARGDRAEAARVLGAGAANLVGLLDIDRVVLGGRTVAADEDAYVRGVRAVIEERAARGGGGGSVTVTVAGGGDRPVAEGAAQLVLAPVFGRVGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZME3</accession>
    <name>A0A7K2ZME3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001424">
        <property type="protein sequence ID" value="MYW33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="17740" checksum="0B52AA45FBDE53A4" modified="2021-04-07" version="1" fragment="single">AALGFDTALLVDAVDRQTGIETLAGPGTPLLTVTEPTETATAAAFAHTAVLAGKPQNAAPLAEAGRLFGRLAHLLDAVEDREADAASGAWNPLTVTGTPLTEARRLCDDALHGVRLALREVEFTDGRLVHVLLAHELRRSVDRAFGTSSCSHQGLEVPQGMLSPDASFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMZ3</accession>
    <name>A0A7K2ZMZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001446">
        <property type="protein sequence ID" value="MYW33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="301" mass="32177" checksum="BF58B32165AB110B" modified="2021-04-07" version="1">MELRHLNAFLAVAEELHFGRAAKRLQMAQPPLSQQIRQLERELGVQLFHRNTRSVRLTSAGESFLEPVRTVLDDLDTAVRAARSAGIGEYGRVTIGFAGASSYETLPQLTRAVRAAHPGLELVMTGQTYANTALARVADGSLDLGFVRLPVTRPGVAHRVIDEEELVCALPSDHPLARRDAVPLDVLAGEPFVSFPANSGSTVRDAMTEACESAGFTPRVVQEAPDSYTILALVAAGVGVTLTVTSVQHIQQNGLVYRPLAGPPIRLRAALAWRADNPSAALRAVLAVAEGALPTPVPHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN49</accession>
    <name>A0A7K2ZN49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001455">
        <property type="protein sequence ID" value="MYW33760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9284" checksum="4C2F42DEC8CABDEB" modified="2021-04-07" version="1">MTPGPPGRAGVAAVVLVRRDRAAPTGWTTVVRLLGLLPGHWCCHPEVGQDRVVLRIELAGSTDAPAVRRAVSCVLADTALRGWTEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNB2</accession>
    <name>A0A7K2ZNB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="103" mass="10832" checksum="1106BE06972C6F99" modified="2021-04-07" version="1" fragment="single">MVESWVNSAEILGSDLPLELSGTGNRRAVLMGALREAVRSGRLSPGTRLPPYRSLAADLGLARNTVADAYAELVAEGWLAARQGSGTRVAGRAAPVTPAHRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNH5</accession>
    <name>A0A7K2ZNH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001490">
        <property type="protein sequence ID" value="MYW33887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="58" mass="5730" checksum="CF12EB9C203EBCBC" modified="2021-04-07" version="1" fragment="single">MVRTKPAARVRYAAGLTAGLLLLALAVAGGLAVGAQPVPPAEVLAALFDPDAPHASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNP2</accession>
    <name>A0A7K2ZNP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001506">
        <property type="protein sequence ID" value="MYW33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="255"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="322" mass="34962" checksum="5F031B2AA96EADE5" modified="2021-04-07" version="1">MLQVLGLSQRAESVYRAMLRWPHHGIAALASDTGLSENAVCRALDELASLELLKPSAQEAGHLRPVSPTVGLTALLANAEAQVCTQQARVESTRAAIATIAAEHDHPHDRALRLEGLDAVRARLEVLQRDTEIECLSLNPGGAHRPDARQAATPLNEEALRRGVTIRAVCRESFRNDADTLGYARWLTEHGGHMRTLPTVPIQMVLVDRKAAVVPLDPADPRAGALEIRTLGAVNALYALFEQVWQQGTPFGEQPPTDLNGCTPTERALLQISAAGDTDETAARKLGVSLRTVRRMMSSLMERLDAASRFQAGLHAAKRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP55</accession>
    <name>A0A7K2ZP55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_33850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001547">
        <property type="protein sequence ID" value="MYW34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029598674" description="Histidine kinase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="252"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="465" mass="50047" checksum="2E9C1E7A179F79F1" modified="2021-04-07" version="1">MRTRLLPLLITLMAAVLLTLGFPLAVSVAAAEQQRLVIDRIDDTARFAALAQPITDTVPAHDERRLTLATDLEVYASVYGIRAGVFYRDDLALAKAPGTWMLPAEGEGRTAFNEALLGRRSHDPPQVWPWQDGRVVVASPVVRDGDVVAVVVIDSPTDEMRSRTLRTWLLIAVGEALAMLVAVGAAVRLTGWVLLPVRVLDAATHDIAVGRMRSRVAAAGGPPELRRLARSFNEMADNVEDVLEQQRAFVADASHQLRNPLAALLLRIELLALELPEGNEEIAAVRTEGKRLARVLDDLLDLALAEHAEADLQLTDIVPLTAERVASWRPMADGKGVRLVQDGAPAATAWADPVALSSALDAVIDNALKFTPAGEEVRVTVTPGATATAVVVADRGPGLTDQELERVGDRFWRSARHQNVSGSGLGLSISRVLLAAGGSSITYERHEPHGLRVTVSVPRELPYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPJ6</accession>
    <name>A0A7K2ZPJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_34490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001584">
        <property type="protein sequence ID" value="MYW34247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="33420" checksum="8D50514CAAC511CA" modified="2021-04-07" version="1">MTSIDVHQLTKAYGTTRAVDRLSFRVRPGSVTGFLGPNGAGKSTTMRLVLGLERPTGGTATIGGRPYAQLAEPLRTVGALLDAQAAHGSRTPRSHLSVLAASNGIAASRVETVLEETGLADVGARRIKTFSLGMRQRLGIAAALLGDPAVVMLDEPSNGLDPEGIIWIRELMKRLAREGRTVLVSSHLMIETASFADHLVVLGRGRLLADLPMREFLDSRSRPRVHLRTTEQDRLRSALATRGLTATQAEDGRWVIDGVTAEAIGTLAADEGIPLLELADERATLEQAYLDLTSDDTPFAASSTSTRQEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ27</accession>
    <name>A0A7K2ZQ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001607">
        <property type="protein sequence ID" value="MYW34388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26242" checksum="3CB6D5542390F2CC" modified="2021-04-07" version="1">MFTDQGPTLRELAVQALSSTERGYDLLAPKFDHTPYRTPDRVLDSVTRALEPLGPFDTGLDVCCGTGAGVGVLRQVCRERVAGVDFSAGMLAEARTALPPMDGGPAVDWVRADALALPFAPAFDLALSIGAFGHFLPADRFGLFAEVYGSLRPGGRFVFPIGAPPAVGSRAYWSLLGFDAAMRVRNALWRPKFIMYYRTFRLSDVLDDLTDAGFSVRLMALTDLGQRPDGSPRARLVVATRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ88</accession>
    <name>A0A7K2ZQ88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001631">
        <property type="protein sequence ID" value="MYW34513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="212" mass="23567" checksum="874089E24EB3368A" modified="2021-04-07" version="1">MAKQDRAIRTRQAILMAAAETFEKHGYQAATITEILKIAGVTKGALYFHFPSKEELALGVIEAQDPPPPTPDQILKLQELVDMGMLFSHRLHTSLLTRAGVRLSMDQQAQGLDRTGAFLRWQQTTHDLLAQAKQNGELLPHVNPTETADLYVAAFTGIQAVSQTLTNYSDLEQRYVTLQRHILPSIANPSILTALDLSPERTTRLARLIPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQH8</accession>
    <name>A0A7K2ZQH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cutinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001637">
        <property type="protein sequence ID" value="MYW34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029842456" evidence="2">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23410" checksum="8D4DB1AE12185F02" modified="2021-04-07" version="1">MRAKRMAAASAGLLLTAGLSVTQASTAQAAAPCHGTYTIVVGGTGSSWNNDGFTGNIQQHVGYPTQIPNGASARAGVNELNRLVRDQRAACPNQHVKMGGYSLGAAVVHTWVTENWQTFDRVNAILISDPKRQGGPGANGGAVPFGGIVGAPLAGADRFFGNVPVKTICHWDYVCDESAGIWTYPHNHINNYPNDFNMDHHNNSANEQWYNGAWHPASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQM7</accession>
    <name>A0A7K2ZQM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_36690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001676">
        <property type="protein sequence ID" value="MYW34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_031123360.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001676.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="167" mass="18777" checksum="81218D7A84E6B784" modified="2021-04-07" version="1">MQFGRTFEEFEVGAVYKHWPGKTVTEYDDHLFCLLTMNHHPLHMDSNYAESTTDFGKNVVVGNYIYSLLLGMSVPDVSGKAIANLEVESLKHIAPTFHGDTIYGETTVLDKTPSKSKNDRGIVYVETRGYKQDGTVVCVFRRKVMVPTETYIKERGGEQPGRPTPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQQ4</accession>
    <name>A0A7K2ZQQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001679">
        <property type="protein sequence ID" value="MYW34696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18000" checksum="5F7E0120A6C36911" modified="2021-04-07" version="1">PHFSGATGTWALPLPTVDPAVVGRSARALERYGPDFRYRHFASVKTLPMALGGPAAVGALVAAAQVGPVRDWLMGRYEAGQGPDAERRKRSWFSVRFVGEGGGRRVFTEVSGGDPGYDETAKILAESALCLALDKLPETSGQVTTATAMGDALLERLTAAGLRFRVAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQW6</accession>
    <name>A0A7K2ZQW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001683">
        <property type="protein sequence ID" value="MYW34742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029616691" evidence="1">
        <location>
            <begin position="28"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="56"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="33959" checksum="DA5C3A7C7A21D30F" modified="2021-04-07" version="1">MKNQYLVWPALAAAAALALSGCGTTEAPKKESAKETSVTVTDSRGKKVTLDGPAKRVVGTEWNVVETLVTLGVQPVGVADVKGYTAYDKSAPLTKDVKDIGTRGEPSVATVAGLKPDLIVATTDLSDSAIAQLSKAAPVVVVRSADASGQIDQMVDNVNLIAEATGTEEKAKSEIASFRKAIEDGKKKLSAAGLGGKEVAFADGWQEGNQVSVRPYVKGSLLADVNSELGLVSPWKLEGDKAYGLAATDVEGLTKIGDARFTYIANDSDGGDPFAEGLKDNAVWKSLPFVKKDQFHRLPDGIWMFGGTAAMREYIDALVGALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRA3</accession>
    <name>A0A7K2ZRA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SseB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001709">
        <property type="protein sequence ID" value="MYW34876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="20653" checksum="9D4CEC3E88667A20" modified="2021-04-07" version="1" fragment="single">MALKNIPDSGFSDDDGSASPALTRALDAWSRDRTAVGPVLAALREARLLVPVVAVLGEVEEDENGLRREKTSDMAVPTLKAGDRRALPAFTSTDSLARWDPEARPVAVPLHQALQAAAHEKADTVVLDLAGPVAFELSGQALLALAENRTSTDPLQDPAVIDAVREAVAAEPAVLRAHLGPGRADGTLALVLAPDAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRJ1</accession>
    <name>A0A7K2ZRJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001731">
        <property type="protein sequence ID" value="MYW34953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051884138.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001731.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="12776" checksum="CA9303AA38A908D9" modified="2021-04-07" version="1">MRCVIARFPFDLFKNEVEDSMKGIKPEPVTGDAVVISRRVYPVKQVGEVITRQDRRDFSSAEVVRALSKLGFTCRTAETAPAPAAAAARTPLETASALLGTPAVAAPAPAPAPGPAQGSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRK3</accession>
    <name>A0A7K2ZRK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001732">
        <property type="protein sequence ID" value="MYW34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="20185" checksum="2FBCB1A2470AE8EF" modified="2021-04-07" version="1">MGVSLSKGGNVSLTKAAPNLTAVIVGLGWDARTTTGGDFDLDASALLANAEGKVAADGNFVFFNNLKSPDGSVEHTGDNLTGEGEGDDEVIKVNLAAVPADVDKIVFPVSIYEAESRQQSFGQVRNAYIRVVNQADNSELARYDLSEDASTETAMVFGELYRNGAEWKFRAIGQGYASGLRGIAQDFGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS13</accession>
    <name>A0A7K2ZS13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_39340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001783">
        <property type="protein sequence ID" value="MYW35174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="235"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="435" mass="45564" checksum="AE59991FF85DA025" modified="2021-04-07" version="1">MTEAPPASPPPSPPSRFRALLPDLSPWRSSPDFRLLWIQGLITYFGSFMALIALPLQIKHLTGSPLAVGAMGAVELVPLVVFGLYGGALADAVDRRRVILLTEAGLGVLAAILLVNALLPEPLLWPLYVVAGGVAALAGLQRPALDSLMARIVPHQQQTAAAALNSLRWQIGAIAGPALAGLVVAYAGHGTAYAVTVCTFAASVLLCLRLSPAPPAKEAAKPSLRGIVEGARYAWSRPVLLGTYAIDLAAMFFAFPNTIFPFLADELDAEWSLGLMYAAGSVGSLALGLTSGWTSRVRRHGLFVVFGAAVWGLAIAAAGWFSSVWVVLVCLGVAGAGDMLSGLGRSTIWNQTIPEELRGRLAGIEVLSYSVGPQLGQVRAGAMAGWTGTRSAIWTGGVACVASVALLTAALPKLVRYDSETDEDAVRRREARVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS83</accession>
    <name>A0A7K2ZS83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001789">
        <property type="protein sequence ID" value="MYW35192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="8202" checksum="6A13BD53DF77A654" modified="2021-04-07" version="1">APLAEGPVTEERLWRLWVIPSPGAKAVRISRILDDVWSREHTFVYPGRPMADGVLATPCYSAANDLCVRVVPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZT07</accession>
    <name>A0A7K2ZT07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35650</name>
        <name evidence="3" type="ORF">GT040_40720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001625">
        <property type="protein sequence ID" value="MYW34468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001851">
        <property type="protein sequence ID" value="MYW35427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="65" mass="6830" checksum="3A26A50788CEA6CD" modified="2021-04-07" version="1">HGEPSSEHGEPSSEHGEPSSEHGEPSSEHGEPSSEHGEPSSEHGEPSSEHGEPSSEHGEPSTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z602</accession>
    <name>A0A7K2Z602_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000010">
        <property type="protein sequence ID" value="MYW27766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="170"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="359" mass="38175" checksum="880A6E0983192EF5" modified="2021-04-07" version="1">MSDSTLDLTLDGPALTARLVDIPSVSGEEKALADAIETALRGLPHLTVDRHGNNVVARTDLGRTERVVLAGHIDTVPIADNVPSRLDADGTLWGCGTTDMKAGVAVQLRIAATVPEPNRDLTFIFYDNEEVAADLNGLGHIATAHPDWLAGDFAVLLEPSDGEVEGGCQGTLRVHLRTAGERAHSARSWMGSNAVHAAAPILAKLAAYEPRRPVIDGLEYHEGLNAVGIEGGVATNVIPDACTVVVNYRYAPDRTEEEAIAHVREVFADCGVAEMIIDDHSGAAMPGLSHPAAKAFMEAVGGTARPKFGWTDVSRFGGLGVPAVNYGPGDPIYAHKRDEHVAVEKITHCENRLRSWLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z661</accession>
    <name>A0A7K2Z661_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3151 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000019">
        <property type="protein sequence ID" value="MYW27816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514127.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000019.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014487">
        <property type="entry name" value="DUF3151"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11349">
        <property type="entry name" value="DUF3151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017349">
        <property type="entry name" value="UCP017349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14767" checksum="C69E93FB1345F8EC" modified="2021-04-07" version="1">MSIHENLLGGPAPTHLPDDPEPRELLAAGTPPAEVAAKYPTSSLAWAQLADEAYEGGRVIESYAYARTGYHRGLDSLRRAGWKGHGPVPFEHEPNRGFLRALHALARAAGAIGETEEHERCSTFLRDSSPTAADILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6D3</accession>
    <name>A0A7K2Z6D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000054">
        <property type="protein sequence ID" value="MYW27901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="13816" checksum="CDE11C4DD7D7E89E" modified="2021-04-07" version="1" fragment="single">MTGGTAGYAAHAAALCAGAAVWLVAMREPGARRARVLFVDGPAEPWRSWSFLLTARELAVERREWWCVPVAVLLAVLGASVLPLIAGAVAVPLVRRWMRGRARRRQCERAADSVAALCAAVVGELRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6G6</accession>
    <name>A0A7K2Z6G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000057">
        <property type="protein sequence ID" value="MYW27934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="30154" checksum="5889C4F08FEEB29B" modified="2021-04-07" version="1">MFTIGDFARYGRVSRRMLRHYDAIGLLRPNRTDPATGYRFYGAAQLARLNRIIALKDLGFTLQQVRDVLDERVGPEELRGMLRLRRAELAEAVAAATARLAQVEARLRSIESEGHMPADDVVIKTVPAVRVAELTGIAASYEPQDIGPVIGPLYEELFPLLEGTGVRPTGPGIAWYEDAPHGSPEGGGAVVVHAGVTVSAPVGPVGGTGVRVVELPPFEAATIVHRGAMDDVLPAAQTLARWLDANGYRSTGYAREVNLECPADRSQWVTELQEPVAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z702</accession>
    <name>A0A7K2Z702_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_02290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000102">
        <property type="protein sequence ID" value="MYW28129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="34"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="479" mass="50914" checksum="51F9379F057C0033" modified="2021-04-07" version="1">MTSQTTLAKPGQEPGEPDRPDSSGGLQAGLKNRHLSMIAIGGVIGAGLFVGSSAGIAAAGPAILISYAMVGLMVVLVMRMLGEMAAARPSSGSFSAYADQALGRWAGFSIGWLYWFFWVVVLAVEATAGAKILESWIPGVPQWAWALIVMVVLTATNLVSVGSYGEFEFWFAGIKVVAIGAFVVVGFLAVFGFLPGSDNPGSGLAHLTDSGGFFPEGPGAILTGVLMVVFSFMGSEIVTLAAGESSDPQRAVSKATNSVIWRIAVFYLGSIFVVLTLLPWNDPSIQEKGSYVAALDSIGIPQAGNVMDFIVLTAVLSCLNSGLYTASRMAFSLGERGDAPKSFAQVNKRGVPQAAILSSVVFGFVAVFFNYQWPDTVFAFLLNSSGAVALFVWLVICFTQLRMRGIILRETPDKLVVRMWLFPYLTWATIAAISFVLVYMLTDDTAREQVVLSLLVAALVVGISLVREARSRKAVTPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z717</accession>
    <name>A0A7K2Z717_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000105">
        <property type="protein sequence ID" value="MYW28147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="16811" checksum="3C581A8632FA0844" modified="2021-04-07" version="1">MESGEPELYSIGEVAERLGLHVRTVRNYVRDGRLKAVRIGKQYRISRADFEALTGSSGTASADVGRGHLEVSSIVQIDAIGPEAAHRLSTFVTASARSSRDAPDPLRVQTVHDRERARMKIVILGGAAPTAELLHLIDGVLGPENGLLDGGPEAHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z753</accession>
    <name>A0A7K2Z753_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000111">
        <property type="protein sequence ID" value="MYW28180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="11288" checksum="29DBEDD516A54F30" modified="2021-04-07" version="1">MKFDMGASVLSTLISHSQGASTDLGTLIRQLIAAAEPLEGKFNGAGKVAFDDFKNRSDEITAALNASLSGILGGQSGMDAAFGSGDQEQGENAKTQMASANFDAARFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7J9</accession>
    <name>A0A7K2Z7J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000144">
        <property type="protein sequence ID" value="MYW28288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045684">
        <property type="entry name" value="DUF6191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19690">
        <property type="entry name" value="DUF6191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="109" mass="11862" checksum="4F588704B55E0042" modified="2021-04-07" version="1">MFNFFEELFAPGRKHGADEQKRLELSRVDVAAGDPGRGPIDLTSGKVTVRAPEAEPAPDREHGPAERMRNAPLEQDAVLAPRTRVVTEPVDGREARGDGDDGHDGPPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7S3</accession>
    <name>A0A7K2Z7S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000152">
        <property type="protein sequence ID" value="MYW28391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="493" mass="53907" checksum="326C42FC3A75ACC1" modified="2021-04-07" version="1">AGPRPAPGPAADEGLSRRLRALACTAPLHDLDVRKANLAGEYTVYAMAEVALAAIDHVTLNMDFDTGADHDQIVARLLPRVGAQAPDRPVAEHERVARWVLENLINVGSVDRGFRAVYGTFGPDGVYVRRDYDFKLIEEVPGYGGTVYLRATDEAVNVLVGALDTDVTSAQIAAEVKLEVLISRGRLADAQLAAEQARYRTVQYAETLRRTLEATRRNVRAVDWLTTVPDMIAEALDHVADRYRHENAILTNIRKARDEAEDPEHKRRAAELVDIVKDCIRRHTQLQSRLLEAGPLFRAEQDRQAFATPTAHAGLDLYGQLLAPLLPLPVEQSTRATDAFFAHGTGLRTPTSVRVGDLVDMLLTPPLEREHLGMEMPEPDLIATPDDSRFSDAQLSSAMALLDLEHDAPRRLSGLLAEARRSDPELPYLVALLAVHAASPPVGTAYRQGERRLLFAVDDGTELDDPEFGGADLIVGMALLDAAGMAADRQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Y6</accession>
    <name>A0A7K2Z7Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_04060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000179">
        <property type="protein sequence ID" value="MYW28470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029798795" evidence="2">
        <location>
            <begin position="33"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="66"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="247" mass="26174" checksum="5DA443D13D89CBD6" modified="2021-04-07" version="1" fragment="single">MSPAPPRWSRYATALAALLATALAVPTATATADDPDARSPRAAADIPAADYQQVQLALGPDELGEAMSLAVLPDRSVLHTARDGTLRLTDAAGSTRTAGKLDVYTHDEEGLQGVGVDPDFAANRYVYLYYSPALDTPPGDAPTTGSAADFEPWKGHLNLSRFVLKADGTLDTASEKVVLEVESDRGQCCHVGGDIDFDAAGNLYLTTGDDTNPFESSGYAPIDERTDRNPQFDAQRSSGNTNDLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z804</accession>
    <name>A0A7K2Z804_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3105 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000171">
        <property type="protein sequence ID" value="MYW28452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="23565" checksum="DAEE4155BE7C9A28" modified="2021-04-07" version="1">MAAAKNQNSPANARRAKLEEARRKERARERRGRLITIGASVAVVLALVAGGGYLVYQANEKDKKEEQAKASPVTGERSWDDLGREHVATKVDYPMNPPVGGDHNQVWMNCNADVYTAEIPKENAVHSLEHGAVWVTYNDKAPEADVKALTDKVKSTPYSFISPVKDQKEPLMLSAWGKQVTVESASDSRVGQFFSKYVQGPQTPEPGAACTGGLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z831</accession>
    <name>A0A7K2Z831_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_04290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000195">
        <property type="protein sequence ID" value="MYW28510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="145" mass="15994" checksum="5FD1B722F10B0B8F" modified="2021-04-07" version="1">GADDYLTKPFSVEHLSARMAAVLRRSRAAGDQAPPPRVIRVGGLAIDPLRRRAELDGTELDLTRREFDLLTFLAGRPGVVVARKELLAEVWQQSYGDDQTIDVHLSWLRRKLGETAARPRYLHTLRGVGVKLQPPAGTPAVEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z863</accession>
    <name>A0A7K2Z863_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DJ-1/PfpI/YhbO family deglycase/protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000194">
        <property type="protein sequence ID" value="MYW28498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="187" mass="19949" checksum="72E4940E4CAFD63E" modified="2021-04-07" version="1">MATTDLGNRRILAIVTNYGVEQDELVVPVKHLRDHGAQVSVAAVSDDEIRTLVGDRDPGDTVRPDLTLADVDPAAYDLLLVPGGTLNADTLRLQDATTRIVSSFAASGRPVAAICHGPWALIEGGYVQGKALTSYASLKTDITNAGGSWVDKSVVRDDEGGWPLITSRNPDDLPDFLREIDAVLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8E4</accession>
    <name>A0A7K2Z8E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000215">
        <property type="protein sequence ID" value="MYW28627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="13"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="275" mass="30397" checksum="42F23191DBD6737F" modified="2021-04-07" version="1">MTHARQRSPQTSIQVVAHRGASDDAPEHTLAAYRKAIEDGADALECDVRLTADGHLVCVHDRRVNRTSNGRGAVSALELADLAALDFGSWKDREESPDWDPVPGELTSVLTLERLLELFTEVRATGRPLQLAIETKHPTRWAGQVEERLLQLLNRFELASPPADEPSPVRIMSFSGRSLHRVQAAAPALPTVYLMQFVSPRLRDGRLPAGSRIAGPGMRIVRSHPGYIERLHRAGHRVHVWTVNEPADVELCAELGVEAIITNRPKQVLSQLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8E7</accession>
    <name>A0A7K2Z8E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000204">
        <property type="protein sequence ID" value="MYW28575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14752" checksum="C17448F6C7594EA5" modified="2021-04-07" version="1">TYLHLALHAVADQDDPGTSRFLLPDLDLTFAEIAARRGGWGRLAYLSACETTYSPRDLADEAIHLTAAFLLVGFSGVIGTLWRVPDAVAETTAAVFYDALDTVRDDPALALARTTRLVRVHYGGAPAAWAAHHHVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8R6</accession>
    <name>A0A7K2Z8R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malonic semialdehyde reductase</fullName>
            <ecNumber evidence="6">1.1.1.298</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.298" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000249">
        <property type="protein sequence ID" value="MYW28737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510262.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000249.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035527">
        <property type="term" value="F:3-hydroxypropionate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02148">
        <property type="entry name" value="RutE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023936">
        <property type="entry name" value="RutE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="21427" checksum="70B69743C03101FD" modified="2021-04-07" version="1">MSLVLDPAAQDLLFREARTANTFTDEPVTDEQVQAIYDLVKFGPTAFNQSPLRVVLVRSAEGRERLVQHMAEGNRPKTATAPLVAILAADNEFHEELPALLPHFPQAKDLFFAERPVRESAAGLNAALQAAYFIIGVRAAGLAAGPMTGYDAAGIQKEFLDDDHTPLMVVNIGKPGEDAWFPRSPRLSYDEVIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9J1</accession>
    <name>A0A7K2Z9J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-IB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000310">
        <property type="protein sequence ID" value="MYW29013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="30611" checksum="D44CDBE30EC44ED9" modified="2021-04-07" version="1">MLSVVENCFSPRTAAFFDLDKTVIAKSSTLTFSKSFYQGGLINRRAVLRTAYTQFVFLAGGADHEQMEKMRAYLSALCKGWNVQQVKEIVAETLHDLIDPIIYDEAATLIEEHHTAGRDVVIVSTSGAEVVEPIGELLGADRVVATRMVVGDDGCFTGEIEYYAYGPTKAEAVRALAASEGYDLSRCYAYSDSATDVPMLEAVGHPHAVNPDRALRREATLREWPILVFNRPVRLKQRLPDFSMPPRPAIVAAAAVGAAAITAGLVWYASRRRTAGSALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9L1</accession>
    <name>A0A7K2Z9L1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">GT040_07090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="WWKE01000317">
        <property type="protein sequence ID" value="MYW29046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW29046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="30274" checksum="F423A7EF72EFEC9F" modified="2021-04-07" version="1">MSTSQITFLKGHGTENDFVIVPDPDNALALPASVVARICDRRAGIGGDGLLHVVRSAAHPEAQDMAAEAEWFMDYRNADGSIAEMCGNGVRVFAHYLQREGLVEQGGLAVATRGGVKQVHLAKDGDITVSMGRALLPEASATVTVGERNWPSRNVNMGNPHAVAFVDDLAHAGDLLSAPPVTPAAVYPDGVNVEFVVDRGPRHVAMRVHERGSGETRSCGTGACAVAVATARRDGRDPAVTGLPTTYRVDLPGGTLTITEHPDGSVDMTGAAVIVAEGTIDPAWLETVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9M3</accession>
    <name>A0A7K2Z9M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_07095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000317">
        <property type="protein sequence ID" value="MYW29047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="84"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="424"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="548" mass="59421" checksum="D1656FBC41DF2057" modified="2021-04-07" version="1" fragment="single">MSAEAADPAAVPRRRSRPRIDLRRLGRVALLGPVPRDRLPDAIGHVAEAHRAHHPDADLGILHRAYVLAESSHRGQMRKSGEPYITHPLAVTLILAELGAETTTLTASLLHDTVEDTEVTLDQVREQFGEEVCYLVDGVTKLEKVDYGAAAEPETFRKMLVATGNDVRVMSIKLADRLHNMRTLTVMRPEKQARIAKVTRDVLIPLAERLGVQALKTELEDLVFAILDPEEYEDTRALIAGVTGGSDPLAPIADCVRATLREAGISAEVLIRPRHFVSVHRVRRKRGELRPTDFGRLLVLVGEDADCYAVLGELHTCFTPVISEFKDFIAAPKFNLYQSLHTAVVGPEGAVAEVLIRTHRMHKVAEAGVVALGNPYAPDPTAAQQTEPSDERADPTRPGWLSRLLDWQESATDPDTFWTTLRADLAQDREITVFGTDGRTLGLPAGASCVDAAYAQHGERAHTSIGARVNGRLATLSTVLSDGDTVQLLLAQDTPSGPSPEWLDHARTPAARIAITGWLSAHPDAPGPEAEGPAEPAADGPQPTAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9P9</accession>
    <name>A0A7K2Z9P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000307">
        <property type="protein sequence ID" value="MYW29005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="20627" checksum="1F965C6355FF5574" modified="2021-04-07" version="1">AFGRVAAASGLRRVVLLSGRGEPQAAVAEEALRGACGEFELTVVRSAFFAQNFSEGALLDSVLGGELVFPAGSAAEPFLDIDDLADVVVAALTGDGHAGAVYELTGPRSLTFEEAAEELGRAAGRPVRYVPVSGPAYAEVLEGFGVSGPEAGFLAELFATLLDGHNSATTDDVKRVLGREAKEFTAFTREAARDGAWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9V4</accession>
    <name>A0A7K2Z9V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000329">
        <property type="protein sequence ID" value="MYW29082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="571" mass="58307" checksum="3C088B5F6EA7E9A4" modified="2021-04-07" version="1" fragment="single">GLGPAVEAETEALSLPGPADTHEKTPRDLRLDPARSALDGRRELLLRRLTACGIPYAQEQGVTGAAGSEGLTTRWQVRWTPATAAMLTAAGVRGVTPAQAAEGVLRGRHATERAEGGPTAAQVVRGLTEAAECGLPALADERLTELAAVLPASGTLPELLAGLDLLDRIAAGHLPGLGAPSDPSRPKAANAVAPLSTRVAHAAELLTSAAVRQVDGLTGSEEPEDARALLELAQRADRLGGIRLADALARLAADGTPLIAAAAGAVRVLTGHEEAETFGVRVASWVDAAVDSPSRAALTARLTGVLTAAGPLLTVGVAALDPLLHRVVELDDAAFLTRLPALRGGFDTLSPAARDRLLGTVEERLGERVDLVGADDPAELARRAVADLAARDLLTALGLPVPSPGDTDRHPPSASATTTRPPVSPAYPRTTGISPATGPDTASGSGPETAPGLETVPGPERTPVRTLAPADRWRLVLGRRPDQLPSGAARLATALDELYGAGRGEGSRGGLPTPGGSRGGREAPFPGVREWSEELAALFGPGVREEVLAAAAATGRQDVLTELDPAAATPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAF9</accession>
    <name>A0A7K2ZAF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000401">
        <property type="protein sequence ID" value="MYW29323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7329" checksum="9425BD732D26F238" modified="2021-04-07" version="1" fragment="single">VNWHEPGAEELAAALLERGVGVEAGLWSGTEGHRLFRRSPLAPRVLRVLAEVTDTDPATATGSARLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAI6</accession>
    <name>A0A7K2ZAI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000381">
        <property type="protein sequence ID" value="MYW29275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="21897" checksum="79D6D4BFCA7D58C6" modified="2021-04-07" version="1">PEAFRVRAGHQEIRERYGLGARPVILCAARLVPRKGQDTLIRALPAVRRAVPGAVLLLTGDGPHARTLRRLAQDTGVADHVIFAGGQPHAEMPGHYAAADVFAMPCRTRRRGLEVEGLGIVFLEAAAAGLPVLVGDSGGAPDAVRDGETGHVVDGRDVEAVTDRLVGLLRDREAAAAMGEKGRAWVREVWGWGSAYATLERLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAN8</accession>
    <name>A0A7K2ZAN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_09095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000413">
        <property type="protein sequence ID" value="MYW29427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512354.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000413.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="68"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="22412" checksum="225EBA6B1D305A13" modified="2021-04-07" version="1">MTAETSQTLDRGLRVLKLLADTDHGLTVTELSNKLGVNRTVVYRLLATLEQHALVRRDLGGRARVGLGVLRLGRQVHPLVREAALPALRSLAEDIGATAHLTLVDGSDALAVAVVEPTWTDYHVAYRAGFRHPLDRGAAGRAILSARQHTAAGHPGYTLTHGELEAGASGAAAPLVGVSGVEGSVGVVMLADAVPERVGPRVLDAAQEVADALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB24</accession>
    <name>A0A7K2ZB24_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">kdpB</name>
        <name evidence="15" type="ORF">GT040_09630</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="WWKE01000448">
        <property type="protein sequence ID" value="MYW29528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="648"/>
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        </location>
    </feature>
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        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
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            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="404"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="MYW29528.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
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    </evidence>
    <sequence length="714" mass="74335" checksum="7A11DB550FD58DC6" modified="2021-04-07" version="1">MSTLTDPRTAQQASHADHGPAGSRVGSGTLDARLMLRSLPDAVRKLDPRVMVKSPVMFVVLIGSVLTTMLAALDPGDWFGWAITGWLWLTTLFANLAEAVAEGRGRAQAETLRRARTDTVARRVTGSGPGSASRPGSASGSGSGEERVAGTELRIGDLVVCEAGDTVPGDGDVVEGVASVDESAITGESAPVIRESGGDRSAVTGGTKVLSDRVVIRITTKPGETFIDRMIGLVEGAARQRTPNEIALNILLASLTIVFLLAVVSLQPFAVYAGAEQSMIVLTALLVCLIPTTIGALLSAIGIAGMDRLVQRNVLALSGRAVEAAGDVSTLLLDKTGTITLGNRQAAAFVPLPGVGEEELAGAARLSSLADETPEGRSVVALADERHGPYEREAAADGAEWIAFTARTRMSGVDLDGHRVRKGAARSVTAWVRERGGEVPGDAGEIADRIAAAGGTPLLVAVEDAGGPRVLGVVHLKDVVKEGMPERFAELRRMGIRTVMITGDNPLTAKAVAEEAGVDDFLAEATPEDKMALIKREQAGGRLVAMTGDGTNDAPALAQADVGVAMNTGTSAAKEAGNMVDLDSDPTKLIEIVRIGKQLLITRGALTTFSIANDVAKYFAIIPAMFAVAYPSLDRLNIMRLASPESAILSAVVFNALIIVVLVPLALKGVRYRPASADTMLRRNLGLYGLGGLIAPFTGIKLLDLLISLIPGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB63</accession>
    <name>A0A7K2ZB63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="64"/>
            <end position="83"/>
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            <begin position="1"/>
            <end position="37"/>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="MYW29574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="33030" checksum="A05B95329FF4931D" modified="2021-04-07" version="1">MSQAETAGPAGTTGQSPRNPPTETTGTTETTGRPRNPGNPRNPLWTLGILRSEITTTLRRHRTYALLAVLAAVPVLIGIAVRIETGGGGSGSGGGPDGGGGPAFLTQVTNNGLFLVFAALAATLPVFLPMAVGVVAGDAIAGEASGGTLRYLLVAPAGRTRLLLAKYASVLTFCLVATFVVAASALAAGALLFPVGEVTTISGTRISFGEGLVRAALTAAVVAASLVGFAALGLFVSTLTDSGIGAMAATVGLLITVQILDSIPQLSGIHPYLFPHFWMSFADVLREPVHWEELSKNFQLQGLYAAVFGSAAWARFTAKDITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
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    <name>A0A7K2ZB67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
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    <gene>
        <name evidence="3" type="ORF">GT040_09870</name>
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    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000455">
        <property type="protein sequence ID" value="MYW29573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="21164" checksum="EF625B0F34CFCA8C" modified="2021-04-07" version="1">MITPPSSLRRSERSRRATLQAALDLCTEKGYGHVTVEAIAARAGVSKKTIYRWWPSKGAVLLEAFTDALVDATPFVDTGDIGADLRTHVAGAVKLLTVPPFGPAYAGILSELHHDDVLAQALKDQLVDPRVEQAVARLRSAQDQGQIPPGANLPLAVEMLYGPVYYRHVLRKPVQDEETIAALVAHVLRALGAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBF6</accession>
    <name>A0A7K2ZBF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000484">
        <property type="protein sequence ID" value="MYW29686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="8297" checksum="2D53AC928B5A49D8" modified="2021-04-07" version="1">MFKARKIRRAAAHLTATFPEIPVEEATNRARRMVSQYPRTSATMIGDYLVHGERVGRVRDGLMRTWLPEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBJ3</accession>
    <name>A0A7K2ZBJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000491">
        <property type="protein sequence ID" value="MYW29741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="396" mass="42889" checksum="9CDC57A37DADC75E" modified="2021-04-07" version="1">MISIVFTGTAVVLLCFAAYWVRGRGGHRPTGTWAMVALLTSFALAFASYAPAVERAVESVVPHVARLLSNTFTLTAATSVLAFLFQLNLDRERADRQIRLRVIALAIAVAGMTAFFVAEQLTGRNPVLYACYVLIYISYLGYTAKDFLLQTWAQSKRSARRSQRWGLRTTSVGCGFALLYAAYKLFALISIGLGLGLVPDHARCSGPLTPFRCAFSVTAPAVAVLLITAGLTLPALLWPLSQLRRRRWERESFTALEPLWREVTSAVPEVVLDPGTTEVDAHDLDFHLHRRVIEINDCVLALRPYRPASVRDAATAEVARRGAAETPEGEAEVEAAVIAAAVEAKRTGRPLEGDEAPPAAGTGSRRGDLPAETAWLLLVAEAHARRPAPENVGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBL3</accession>
    <name>A0A7K2ZBL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4433 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029494">
        <property type="entry name" value="DarT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14487">
        <property type="entry name" value="DarT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DarT" evidence="1">
        <location>
            <begin position="35"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="26858" checksum="17ED58072746129E" modified="2021-04-07" version="1">MPAVQGEFTVKQRRTRRLHVVYSSLVMNVGGQQLFHFTHVEHLPAMLAEKQLVSDSAMRRRGGVPVECGDQSVKAERRERVITVPPYGHPADYVPFYFAPRSPMMYVISRGGVATYRGGQPPLVYLVTTVNEVVATGNPYVFSDGNCANAITAHFTDLAQMPRRVDWEIMAATYWANTTDDGDRMRRRMAELLVHESLPVSALTEIGTYDRVHAQQVQDALNAAGVDLRVTVRREWYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBM6</accession>
    <name>A0A7K2ZBM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA cytosine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="217" mass="24292" checksum="A193A81F900776A7" modified="2021-04-07" version="1">MLPLRKPNGLRVLDLCCGAGGLSMGYYLAGYDVTGVDLHPMPNYPFTFHQADALDYLATITATGEIERYDLVHASWPCQNKARVTAWRGSRDDHPDLITPGRELQRACGRPWLIENVPEASWDGTLRPDYLLCGSQFGLNVRRHRVFETSWGGGGDLLPPCWHHKGLLAFEHKGERAYADAMGCTWMTNVEARQAVPPAYTQWIGHQFLTHERTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBS0</accession>
    <name>A0A7K2ZBS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000500">
        <property type="protein sequence ID" value="MYW29806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="30"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="22013" checksum="741B94DA1EA696CF" modified="2021-04-07" version="1">MELIQQHPDIAAYLAADETIDHGHSVVRETVAALTHEGDDAYSYARTAFEYVRDTIPHSADSGDPRVTWRASDVLATRNGICYAKSIALTALLRARAIPAGLCYQRLTDDDGTNPGVHGLVALRLPGRDRWARVDPRGNRAGVDARFSLEAERLAWAVREEIGEVDYPALHATPPTEVLHALRSARDRAELWRNLPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBT1</accession>
    <name>A0A7K2ZBT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000501">
        <property type="protein sequence ID" value="MYW29816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="23006" checksum="FA6E3B6A89A134AF" modified="2021-04-07" version="1" fragment="single">MDRTEPQLLCSVDGGIATVVISHPAKRNAMTAGMWRSLPDLLERLAADPAVRVVVLTGAGDTFCAGADISTLRESAGDAQALAVAAEEALAAFPRPTLAAVRGYCVGGGSQLAAACDLRFAQEGALFGVTPAKLGIVYPSSSTRRLVGLVGPATAKHLLFSGELIGTERALRTGLVDEVLPAGGLDERVAAYAGVLASRSRLTQAAAKEFAAGRRDRDGYWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC46</accession>
    <name>A0A7K2ZC46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000545">
        <property type="protein sequence ID" value="MYW29924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06553">
        <property type="entry name" value="ASCH_Ef3133_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009326">
        <property type="entry name" value="DUF984"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39203">
        <property type="entry name" value="PTHR39203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021320">
        <property type="entry name" value="DUF984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="12"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16130" checksum="AA230DB3F3C65A13" modified="2021-04-07" version="1">MEPREPLAPFLLAFPGPLRDRLVAAVLSGEKVSTSGLLAEYELEGEELPPVGERSALIDSEGREVAVVEMTEVRVLPLGEVDLQHALDEGEGYRSVAEWRAGHEAFWHGEEMREAMGDPSFTVDDGTMIVAERFRVVERLDGGGVPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC56</accession>
    <name>A0A7K2ZC56_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000545">
        <property type="protein sequence ID" value="MYW29919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="10064" checksum="E19FA0646E60CE98" modified="2021-04-07" version="1" fragment="single">MRFGVLGPLAVWTADGRTVRVPELKVRALLALLLVEQGRPVSADRLIDALWGANPPGNPTGVLQTKVWQLRRALEDAEPGARELVVSLAPGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCR2</accession>
    <name>A0A7K2ZCR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="91" mass="10015" checksum="0972B1649A3A8925" modified="2021-04-07" version="1">MAELTTRRQHLAKRMYGKGGLSIRCSCGKYTPVAGTVRQQEDAHRAHRVAMGERIKERALSPLEKARDRIAELEAENAALVKALGLNESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDD9</accession>
    <name>A0A7K2ZDD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000659">
        <property type="protein sequence ID" value="MYW30371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029829332" evidence="1">
        <location>
            <begin position="40"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="418" mass="44934" checksum="10A22BFD8D84C2AA" modified="2021-04-07" version="1">MAVRGRDARGRRPRLPRRAAGPVLAVLLTASACSAPADADTSLTVREIDATLERRAAAVLARDPAGYLDALAPDAAKLRAAQRTELANLADVPLKSWSYEVKGITEEDGDWATAEVELRYRIDGYDTAPVAAHRTLELMRDGERWYVSADRPAKGASDQLWHQGEVEVVRGAHSLVLGVGRPEEELRQIADTVDLAVPAVSDAWPQPWARRVVVHVPDSVESMAGLLGSPETSYRGIAAVTTGEAGTTGERPALADRVIVNPQAYASLGSFGQRVVLTHETTHVATRTSTSTATPVWLSEGFADWAAYRGEDRTPDLIAPELTGAVRAGDVPAGLPDDKDFGFDGDPAELARAYESAWMACELIAERWGKEKLTAFYAAVGAHPGRDGAVEQAMGSVLDTTPEEFTADWRDYLSARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDG9</accession>
    <name>A0A7K2ZDG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="422" mass="45685" checksum="BBD21BE105815A8D" modified="2021-04-07" version="1">MHVHYSQIYVQSDPDGTNSGLGEAFAGQSGGLCGAAVPGALYLVTGLHTGSVGFTVEVHDEEPPPAPDWEDVVEVSFRPVSKDTSLVQWGGEAAWDLALPVTDYRVRYSARGMDQGRDLDTRTAKEPQADSYLLQFWPAPPRPDRVIRETARIAAYWHGYARGRPAPPTPEQRAEAERLARQTKERAAEERRLHYERWQWGGRLPSEALRGARQSNVLGLLPFDSDLVHTLGAVDPEVQHTVALLAARRACEAAGLTGLPWVAGALAALEADRPLPPPFDGPAGPWETLRSDPRVPDTTVLEAVPPEHPPYQPPPPGPDDPYAVVETFPRTPRALHRISQPHYALPAVVAAAGPAPLVAALDAVWHALNTCGEHYPAFLDEIWAVCDGAASETPKWQRESRPTGRAPKQVGAQDEATPGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDU9</accession>
    <name>A0A7K2ZDU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_14875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000713">
        <property type="protein sequence ID" value="MYW30531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="930"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1277" mass="138065" checksum="52008993FE4623BE" modified="2021-04-07" version="1">MSTSTSVPAVLQQRASLPELLRHQARERGDDIAVISAEGRLTFAELHSAAVRMGSHLAGAGVSPDTCVGLFVEPSAELVTGVWGILTAGAAYLPLSPDYPDSRLRYMAADAGVGVVITQSHLRGRLHGLVPAGTLVLTVDEATAGGSSHPLPEPRQDHLAYVIHTSGSTGSPKGVMIEQRSVVAQLRWLERSGYLGPAVSILQKTPISFDAAQWEVLACAAGARVVMSPPGSFRDPQAIIDAIHTYGVTALQGVPTLLRALVDSGELDTCSTLTRIFSGGEALTRALAQELFRTLPGISLVNLYGPTEATINATSLHVSPDTLDDEDLHILPIGRPADGVTCHILDEGLRPTGTGRSGELFIGGVQVARGYAGRPEVTRERFITSPFDPAERLYRTGDLARWRADGTIQYEGRTDNQVKLRGYRVELEEVASRVEEHTWVRRAAAVVTDNPRTGSQVLVAAVELNEHTAAVMDQGRSDAGHHQSKSSKLQVKAQLADPGLREPAELAGRPVIPLAGAEATAEQRRAAFARKSYRFYEGGRPTVEQLGALLTPPPPPAAAAREPGELTAGEIGSLLRWLGPHRSPDRLLPKYAYASPGALYATQLYLEIDGVAGLSGVYYHHPVDHTLVRVGDHPAPGSTAELKIHFLGRRRAIEPVYKNNIVEVLEFEAGHMLGVLEEVLPGLGLMVRPHGFLPDAAARLDVAAEDHYLGTFAVVPHDGLPRPEEVELFVQAHGDRVDGLPGGLYRHQDGMLVRLGDEVVERRHVIAINQGVYDRASFGVSAVPRTGDDWRRYMVLGTLLHRLQRVPGVGLMSAGYSSRTGHPLPAAQRLDDLLDRAAVPAAPASYFFVGGPVSAEQAAHTGMNEDAVHTKGPAEMIRDDAAQFLPDYMVPARVVVVDRLPVTANGKTDLKATALLSEVAAGGNTAPHVEPATPTERWLAGEWGRLLGYEEVSTQDEFFASGGNSLHSVALVNRINRRFGTRLPLQTVFEAPTLAELAARVEHRASSPASRLLRLNTDGAPAQVFVWPGLGGYPMNLRTLALGFDGERSVAGIQAYGINTGETPHATIRQMAEADIAEIRRVRPTGPYTLWGYSFGARVAFEAAWQLEQAGEKVENLLLICPGNPHVRTQEGRKWGREASFANPVYVTILHSVFAGTTHGPAVEACLRETTDEDSFVAFVHRRMPALSEETIRRITQVVSATYEFEYTFRELRERKVEAPVTIFKARGDDYSFLEDSSGYSAEPPRVTTLTGDHYEVLKEQGVAELISGIRALDVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDZ2</accession>
    <name>A0A7K2ZDZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000714">
        <property type="protein sequence ID" value="MYW30542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="381" mass="41675" checksum="CE280746D3386417" modified="2021-04-07" version="1">MRRTGTRWSAARQWVGQEWAEVRRSVRSACEEAGPERDTLVQSLKAAGAAILAWALCGWWFQAPMALLAPWTAIAMVGSTVYQSLRTGAQQFAIIALGTVWASAAMDLTRDQSMAAMLLTLPFMMLLGNYRRFGTQGIYGATTALFVITAGVSSTSTVGHRLLETLIGAVIGLLVNALVLPPVHLRSVRDRLGRVARETADLLDAMADGLREEDGLEGAESWHLRANRLTVSLQDVSDARRWAMEGSRWNPGGRMRRTGPKPPPFAEDMRWGRVCTRLLAVSRTLAGIREDPEFSRPSPDFFRQLSDVLAQAAVICVRETELLTSSEPDTPRDDRDAVAREARAGLDALTESFRRQEGTAAAAGGALLLEVRQLVTELDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE54</accession>
    <name>A0A7K2ZE54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_15255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511963.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000719.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="8"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="110"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="36154" checksum="54B937975561E6D2" modified="2021-04-07" version="1">MEILAFGVQSDEKPLIEKAFAGLHEVRCLDVFLNRDTAPIAAGYEIISTSVNADLGSPVLQTLATGGTQMIAQRSTGFNNIDLDVAERLALRVARVSYYSPYSVAEFAWTLAMAVNRRVIRAASRTRDFDFRLDGLLGRDMHGRTVGVVGTGKIGEAFTRIAHGFGMKLLGWDVVENPACLELGMEYVEKERLFAEADLVSLHVPLLPATQHIINEAALKSMKDDAILVNSSRGGLIDTAALVTELRAGRFLGVGLDVYEAEAGLFFLDKSLEGVDDDTLARLVTFPNVIVTSHQAYYTEDAVGQIIDATVQNVTDYLARRTSENVLVPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE85</accession>
    <name>A0A7K2ZE85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Muramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000731">
        <property type="protein sequence ID" value="MYW30677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="20982" checksum="F581DC085F91F915" modified="2021-04-07" version="1">MLHGVDVSAYQPSYDTEGLDFVFIKSTEGRTYVNPRLDAQVKRARDAECVVGFYHFLWPGDIKDQVAYFLSRTPEKAGDLLAVDWEQTGGGTRASSAEKDRFIREVKRERPGHRVLLYCNRAFWRTHDTSDYAGDGLWIADYVSAGKPRIEASWRIHQYTDDPLDKNVADFDSVRALRDWAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEB3</accession>
    <name>A0A7K2ZEB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="26766" checksum="76A3946BE4F8B3F3" modified="2021-04-07" version="1">MAWSTSQLAELAGTTLKTVRHYHRLGLLEEPARSANGYKRYGVTHLVRVMGIRRLTDLGVPLADIPSMEAADGRPEEILRALDAELAADIDRRRRMRREIAAVLEEGVSLGLPADFGAAAADLPRAQQSLLLAYSSILTPRAMALIKEQYSRPRDEVAEEFENLPVDAPEDVRRRLAGHLAAEARAQQEAHPFISDLDAASRRDGALARSVVAQALVAFYNEAQLDVLRRLHILLEPDGPAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEN6</accession>
    <name>A0A7K2ZEN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000759">
        <property type="protein sequence ID" value="MYW30778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029870981" evidence="1">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="13091" checksum="0562AC4BA63BB740" modified="2021-04-07" version="1" fragment="single">MPLRRSLLGRLLGVSALVAACSVAATAWLAVQTTSGAILQEQGQNLTADARIYDTLLGYAARHPSWDGVDATVRELAEQSGRRVALTTQSRQPLADSATAATVPALPPEASAVVDPLSVDTVLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEP8</accession>
    <name>A0A7K2ZEP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000767">
        <property type="protein sequence ID" value="MYW30834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="17447" checksum="015BFE36D17BF479" modified="2021-04-07" version="1">MATPDFIRTIRATAGHQLLLLPGVTAIVFDDEGRVLLGRRADTGKWSVIGGISDPGEEPARTAEREVLEETGVHCVAERLVLTQALQPVQYANGDRCQYVDITFRCRATGGEARVNDDESLEVGWFPLDGLPPLAEFALFRIKQALTEGPAWFQPSPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF39</accession>
    <name>A0A7K2ZF39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosynthase chain-length factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000810">
        <property type="protein sequence ID" value="MYW30977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="133" mass="13541" checksum="F88E51CCF8C97529" modified="2021-04-07" version="1">PGLRRAAALALAEAGCRPADIDVVFADAAGTPRADREEAEAITRLFGPRGVPVTAPKAAIGRLSSGGAPVDVVTALLAIRDGRIPATPQVEPALTHGLDLVTGRPRTASVRTVLVLARGHGGFNAALVLRAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFZ8</accession>
    <name>A0A7K2ZFZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_18765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000872">
        <property type="protein sequence ID" value="MYW31262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="46"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="308" mass="34113" checksum="D71775F5770CAFA0" modified="2021-04-07" version="1">MLGPVILAASRSDKMRRFISAAPGTKQVVDRFIAGETVDQVVPIVEDAADKGLEVTLDVVGEDITTPAQAEAARDAYLELIERLKALDLGPRAEMSVKLSMFGQALEGGHELALANVRPVVEAAAAIGTTVTLDAEDHTTLDSMFAIHEELRKDFPQTGCVIQSYLFRTEDDARRLAAAGSRVRIVKGAYKEPASVAYQDKAEIDKAYVRITRILMEGEGYPMIGSHDPRLIAIAQELGRQTGRKLDEYEFQMLYGIRSDEHVRLAAEGHRMRVYTAYGTDWYGYFMRRLAEKPANLLFFGRSILTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG08</accession>
    <name>A0A7K2ZG08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_18825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000874">
        <property type="protein sequence ID" value="MYW31272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="695" mass="73704" checksum="8D78ADE4F473EBFC" modified="2021-04-07" version="1">MLLSIDIGASSTKAAVLLDGDDGVVPIEEQGRPEWPTGLLLHPDGALTTGQQAENTRKAPRFRGRYLTGLKQQVNLAGGIEPVHRELLFPSGESRPLVRGFAAVISHVLDAARERYGEPRHVILSHPVMWSEQQRAVLAEAAVAAGCRSASLVGEAAAVGMFAARRRTEQLGEGTFAVFDLGASTFDFALMRAVPDGLPDVVYSTGRHVGGDDFDVRVLDVVRDSADDATRRLLERLALDDPELLKSEAELLKRRLSTHDEVNFAVTDDAPPVTIYREDFAEAVDDLVLACVATARGAITSFPEDIPGTLVLSGGGARTPVVREQVEELVRVLSRLRKDGGGAGEVVLVDLTDDIEGSAVALGVHRRMRSTGKPPRPARPFTLTSAAILLGDPGSEVVALPGGVLERGPDHRIRVLPGRKGGNGGRGGRGDHDGDGPPVPEDRPAVTRIAADVTTGRVVLAYPSPAFACTTTDASGGLRLGSVLGSFAALPTRPEGTVTALARRGELFAWSQTGRRGSTLVEDGAHGWRPLPLREPVRELAFADDRTLLARVAGRIVHLDVRTGHPTGETPLPDSVPLVVGPAGLCCTLSDDELTGWAVTAEGLEQLWRRALRTGGAVALTGWAGERMVVAYDADAEVYRALDGESGRQVALRDAWRLPAPEALLPGADPGVVYARRRTAGGAVLDLLHLAPVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG14</accession>
    <name>A0A7K2ZG14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">metE</name>
        <name evidence="14" type="ORF">GT040_19010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000883">
        <property type="protein sequence ID" value="MYW31303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="13">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="12">
        <location>
            <begin position="204"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW31303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="537" mass="58129" checksum="D743B4E1C3514D92" modified="2021-04-07" version="1">LGGLTDRSKLLVASYFGRLGDALPVLAKSPVEGLALDFTESGAANLADLAAAGGLPGKRLVAGVVNGRNIWINDYEKSLATLGTLLGLADHVDVSASSSLLHVPLDAAAEHDIDPQVARWLAFARQKTQEIVVLARGLSAGTEAITAELASNRADLASRADAAITRDPAVRARTAAITDADGRRSQPYAERTVAQRAHLGLPLLPTTTIGSFPQTTELRTARADLRAGRIDEAGYEERIKDEIREVLSFQEKAGIDVLVHGEPERNDMVQYFAEQLTGYLATQHGWVQSYGTRYVRPPVLAGDISRPEPMTVRWTAYAQSLTERPVKGMLTGPVTMLAWSFVRDDQPLGETARQVALALRDEVNDLEANGTSVIQVDEPALRETLPLRAAEHAAYLEWATESFRLATSGVRPDTQIHTHMCYAEFGDIVQAIDDLDADVISLEAARSHMQVARELAAHGYPREAGPGVYDIHSPRIPSTEEAAALLRKGLEAIPATRLWVNPDCGLKTRGWSETRTSLENLVAAAREIRAELPTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG18</accession>
    <name>A0A7K2ZG18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_18625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000868">
        <property type="protein sequence ID" value="MYW31235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="33"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PDDEXK_1" evidence="10">
        <location>
            <begin position="440"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW31235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="634" mass="69670" checksum="5A183AEFCA6C62AB" modified="2021-04-07" version="1">VISLADALDTFLIAGDAADDGLPFSAEARVRFARLARELRDLRRSLADPLMDVLHRVLATTGLEVELSASPQALAARRRETLANFLDIAASFASLDGEASLLAFLGFLRTAAQYEKGLDNALPGGENTVKVLTAHKSKGLEWDVVAVPGLVTGQFPGDRARDAWTAQAKVLPHALRGDAATLPEVDTFDAKGMKAFKEEMKEHQHTEELRLGYVTFTRPRSLLLGSGHWWGPSQKRTRGPSAFLEALYEHCVAGHGEIEAWADEPAEDEENPALAAPDTDLAWPLPLDVTALARRRAARDTVLAHLESLALHGDEQPPAYAPGPDDVPAHDPWDDEPPADGPPADGPPADEPPFDEDWDWDALPTERPAGTPDTRDDPEPVREAAPHIPAARHPQEEPADHLTPEEARTLASWDRDLDALAGELRRARATVHDVLVPAALSATQLLRLAEDPDAFAKELARPMPRPPQPAARRGTRFHAWVESRYEELPLPMLGPDELPGGDESDAEIADERDLAELKEAFERTAYARRTPYRVESPFQITLAGRVIRGRIDAVYRTGDTYEIVDWKTTRHRTADPLQLAVYRLAWAELHDLPLDAVTATFLYVRTGETVHPQGLPGRAELERILLDEPAPEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG55</accession>
    <name>A0A7K2ZG55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_19215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000905">
        <property type="protein sequence ID" value="MYW31344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="319" mass="33543" checksum="2AB541ABE64FDAFA" modified="2021-04-07" version="1" fragment="single">MSAAHTLYPAVQLAATEGASEHRPLIITLFAAFVVATLFITVWAGRQTKSASDFYAGGRQFTGFQNGLAVSGDYMSAASFLGIAGAIALFGYDGFLYSIGFLVAWLVALLLVAEPLRNSGRYTMGDVLAYRMRQRPVRTAAGTSTIVVSIFYLLAQMAGAGVLVSLLLGITSDFGKIVIVALVGVLMILYVTIGGMKGTTWVQMVKAVLLIAGTLLITFLILLKFNFNISDLLGTAASNSGKGAAFLEPGLKYGATGVSKLDFISLGIALVLGTAGLPHILIRFYTVPTAKAARKSVNWAIGIIGAFYLMTIVLGFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG65</accession>
    <name>A0A7K2ZG65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF2029 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_19035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000884">
        <property type="protein sequence ID" value="MYW31308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="18532" checksum="DFAB6E6DF3C08832" modified="2021-04-07" version="1" fragment="single">MTGRTSKGGALLPCAAWAVTRAALLLWVCGVLTLGTLDVTVDVSVIYRGWYETLLTGTYPLDDVTWQYPPGAALAILSPALLPFWEYASAFYALVLLCDALVFGLLLYAGRRPGIRAAGAWVWVVGVPLLGPTVYARYDLMVTAVAVAALLAGVRHPKVLGVLAAFGALLKVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGJ8</accession>
    <name>A0A7K2ZGJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_19895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000927">
        <property type="protein sequence ID" value="MYW31477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="284" mass="30128" checksum="A262D1B60061A400" modified="2021-04-07" version="1">MSENQNLLAEQRRALILDEVRRRGGVRVNELTRRLNVSDMTIRRDLDALARQGVIEKVHGGAVPVVEASTHEPGFEVKSALELSAKEDIARTAAAMAQPGSAIALSGGTTTYALARHLLDVPDLTVVTNSVRVADVFHDAQRPVPGRGARPGTATVVLTGGVRTPSDSLVGPVADRAIDSLHFDLLFLGVHGISAEAGLSTPNLAEAETNRRFVRSARRVVVVADHTKWGTVGLSSFATLDEVDTFVTDAGLAPGAREEIGEHLPGLVVAGESYEPPEETVFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGK3</accession>
    <name>A0A7K2ZGK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000921">
        <property type="protein sequence ID" value="MYW31448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6182" checksum="BE2B2DE2A3A93745" modified="2021-04-07" version="1">PLRTGVRRSLADPRGSALLASAVVLAALLAWAIPLLVPLLAGPLALAAAAVEHRHGGARTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGR6</accession>
    <name>A0A7K2ZGR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000959">
        <property type="protein sequence ID" value="MYW31551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="10674" checksum="B52B30A3A1868CC9" modified="2021-04-07" version="1">STPAEQSPAVQQQRRRGGGRGANRRPSGRERHDEKITVYVSAEELMDLEHARLVLRGEHGLAVDRGRIVREAVAVVLADLESRGDASILVRRLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGY7</accession>
    <name>A0A7K2ZGY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Malate synthase</fullName>
            <ecNumber evidence="2 7">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_20380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 7"/>
    <dbReference type="EMBL" id="WWKE01000965">
        <property type="protein sequence ID" value="MYW31568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="530" mass="59677" checksum="D6F740C24D774B69" modified="2021-04-07" version="1">MTTLVTTGRVQVLGVPGDRHEEVLTPEALDFIARLDAAFATRRFDLLTERRRRSALLRGGTPLDFSRATKPIRSDPDWRVARPAPGLTDRRVEITGPPDRRMAVNALGSGAQVWMADFEDATSPTWENIVQGQLTLIDAIDRRIDFTSEAGKEYRLTERPATIMVRPRGWHLTEKHLVIDDRPVPAALVDFGLYFFHCARRQIDAGSGPYFYLPKLENRYEARLWNDVFLLAQDLLDIPRGTIRATVLIETITAAFEMEEILYELREHSAGLNAGRWDYLFSLIKNFAHRPDFVLPDRSTVTMTAPFLRAYTELLVRTCHQRGAHAIGGMAAQIPSGSPEAVEAALAKVRLDKEREAEDGFDGSWVAHPGLVPVCRTVFDEVLGDRPHQLERTRDDVHVTAEELVAVRRTAGRPTPAGVRENLAITLRYYDAWLGGRGAVALNGLMEDAATAEIARVQIWQWLKHGTVDRETVERLFEEELATLGATYPWARLDQVRDLFERTALAKELPAFFTTEAYARHLVGRPAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHE4</accession>
    <name>A0A7K2ZHE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_21410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="403" mass="40926" checksum="F35831601E0F1CDA" modified="2021-04-07" version="1">MPLALLALAIGAFGIGTTEFVIMGLLPEVAADFQVSIPTAGFLVTGYALGVVLGAPLMTLLGTRVTRKRMLMLLMGLFIVGNVVSALAPVFGVMLAGRVIASLAHGAFFGIGSVVAADLVAPQKKAGAIAMMFTGLTVANVVGVPLGTYIGQSAGWRTTFVLVALLGVIGLLGVAKLVPEQPKPEGVRVRHELAAFRNVQVLLAMAMTVLGFGGVFAAITYITPMMTEIAGYSASSVTWLLVLFGLGMVGGNLVGGRFADRHLMPMLYVSLGALALVLGLFTVTAHNKVAAAVTIVLIGALGFATVPPLQKRVLDQAAGAPTLASAVNIGAFNLGNALSAWLGGLVIAAGLGYTAPNWVGAVLAASALVLAVVSSLLERRTAGAEGRIVAGSSPAPVATPARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI71</accession>
    <name>A0A7K2ZI71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001072">
        <property type="protein sequence ID" value="MYW32053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6834" checksum="38BFA499A246EB47" modified="2021-04-07" version="1">MNHSPELSTAHWRSSSYSNSNGGECVQVSDDFPGLVPVRDSKNPTGPALVLRATAWSAFVSSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI97</accession>
    <name>A0A7K2ZI97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001076">
        <property type="protein sequence ID" value="MYW32071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="21977" checksum="DE185722E2F3C1FC" modified="2021-04-07" version="1">MTQTPNDNDRTGSTANRATPSTGAERVPPVTPPGDPLGTPVPASAAKPATSPETTPGNRPDGASAPASGTPRADEAHATSARTDGARETGRTTGAASGSRSGTGTATGATTDAGRDAATGKDRPLFSTEEREKFDARIHQAVAGFVENPRQAVQEADAAFDEVVTGLTKALADRSRLLRADRDGERSDAETEDLRIALQQYRDLTERLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZID5</accession>
    <name>A0A7K2ZID5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <ecNumber evidence="2">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_23285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001096">
        <property type="protein sequence ID" value="MYW32116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="8">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="21579" checksum="65EA3BC7EBF65BB6" modified="2021-04-07" version="1" fragment="single">MSAVRTGVTVRVPAKVNVQLAVGAARPDGFHDLANVFLAVGLYDEVTATPADELRITCSGPDAAQVPLDRTNLAARAALALAERYGIDPAVHLHIAKDIPVAGGMAGGSADGAAALVACDALWGTGASRDELLAICAELGSDVPFSLVGGAALGTGRGEKLTPIEVGGAFHWVFAVADGGLSTPAVYGEFDRLTAEADVPEPTASPALLAALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIQ4</accession>
    <name>A0A7K2ZIQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ettA</name>
        <name evidence="10" type="ORF">GT040_23465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001108">
        <property type="protein sequence ID" value="MYW32149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="322"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="554" mass="61590" checksum="A046EE894CE4DFDB" modified="2021-04-07" version="1">MAEFIYTMRKTRKAHGDKVILDDVTLNFLPGAKIGVVGPNGAGKSTVLKIMAGLEQPSNGDAFLSPGYSVGILMQEPKLDEEKTVLENVQDGAAEIMGKLKRFNEVAELMATDYSDALMEEMGKLQEDLDHANAWDLDAQLEQAMDALGCPPGDWPVTNLSGGEKRRVALCKLLIEAPDLLLLDEPTNHLDAESVNWLEQHLSKYPGAVVAVTHDRYFLNNVAEWILELDRGRAIPYEGNYSTYLERKATRLKVEGRKDEKRQKRLKEELEWVRSNAKGRQTKSKARLARYEEMAAEADKMRKLDFEEIQIPPGPRLGSIVVEVENLSKAFGDKVLIDDLSFTLPRNGIVGIIGPNGAGKTTLFKMIQGLETPDSGAIKVGDTVKISYVDQSRANIDPKKTLWAVVSDELDYINVGQVEMPSRAYVSAFGFKGPDQQKPAGVLSGGERNRLNLALTLKEGGNLLLLDEPTNDLDVETLSSLENALLEFPGAAVVISHDRWFLDRVATHILAYEGDSKWYWFEGNFESYEKNKVERLGADAARPHRATYKKLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIR1</accession>
    <name>A0A7K2ZIR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001114">
        <property type="protein sequence ID" value="MYW32228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="19483" checksum="4C1AAD915EE60DC2" modified="2021-04-07" version="1">MSSSYGPQHAPAGDVGAALMLIDSRLRSIHAGNAEADTEQQAMMAQFTESLGPGGAEDLLDGVCTLIYMYMTWLRKAHEDHDKDVIEYVVPSLVASMRMMPKSIRPEAVPTMAGLVIAAGTGLSPSLWRKQYGDWTEAEMTPLEATAFLLAEHINRIADDENFATRVITDALTRAEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ14</accession>
    <name>A0A7K2ZJ14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="5" type="ORF">GT040_24475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001150">
        <property type="protein sequence ID" value="MYW32338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="156"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="33625" checksum="C8263D9B5F28E5AA" modified="2021-04-07" version="1">MKGTVGELGEFGLIRELTSRLTTTPAVRLGPGDDAAVVAAPDRRVVASTDILLEGRHFRRDWSTAYDVGRKAAAQNLADIAAMGAVPTALLLGLVVPADLPVTWAAELMDGLRDECQVAGAAVVGGDVVGGDTITVAITALGDLRNHEPVTRSGARSGDVVAVTGWLGWSAAGYAVLSRGFRSPRAFVEAHRRPEPPYHAGPAAAGLGATAMTDVSDGLVADLGHIAEASKVRIDLRSGLIDIPSQMSDIGQAVGVDPLQWVLTGGEDHAIVATFPPDVKLPARWKVIGEVLNPSALPQVTVDGAPWTSKGGWDHFGAIEDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ70</accession>
    <name>A0A7K2ZJ70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_24740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001156">
        <property type="protein sequence ID" value="MYW32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="27528" checksum="BAF127A4E1D608C1" modified="2021-04-07" version="1" fragment="single">MITFDQVTVEYDGAAEPVLREVNLEVEEGELCLVVGHTGVGKSTLLGAVNGLVPHFTGGTLYGTVTVDGRSTADHPPRELADVVGVVGQDPLDGFVTDTVEEELAYAMEQLAISPTVMRKRVEETLDLLGLADLRHRALYELSGGQQQRVAIGSVLTAHPRVLVLDEPTSALDPTAAEEVLAAVTRLVHDLGVTVLLAEHRLERVVQYADRVIHLPGDGRVVSGAPADIFTTSSIAPPIVELGRAARWSPLPLSVRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ81</accession>
    <name>A0A7K2ZJ81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001157">
        <property type="protein sequence ID" value="MYW32395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="270" mass="29658" checksum="F44A1E3246A3D7A1" modified="2021-04-07" version="1">MRTARARHYLMCRPTYFDVVYSINPWMDPKKPVDTPLAIAQWERLREVYLSLGHTVDTIEPVRGLPDMVFAANGATVVDGRALVARFRDAERIAEGPAYHDWLRDNGFPDLRTASVVNEGEGDYLLVGDLLLAGTGFRSDPRSHDEAQEFFGHPVIGLTLVDPDYYHLDTALTVLDEKTIAYYPGAFSPGSLAVLRRLFPDAVLASAQDAAVFGLNATSDGLNVVLPQNATGLAEQLRDRGFRPVGVDLSELLKAGGSVKCCTLELRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ93</accession>
    <name>A0A7K2ZJ93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_24955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001165">
        <property type="protein sequence ID" value="MYW32430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="355" mass="38252" checksum="849F84E1C84AE67C" modified="2021-04-07" version="1" fragment="single">MSLDHRLTAEHEELRRTVEAFAHDVVAPKIGDLYERHEFPYEIVREMGRMGLFGLPFPEEYGGMGGDYLALGIALEELARVDSSVAITLEAGVSLGAMPLHLFGTEEQKRQWLPRLCAGEALGAFGLTEPDGGSDAGGTRTTAVLDEATNEWVINGSKCFITNSGTDITELVTVTAVTGRKEDGRPLISAIIVPSGTPGFTVAAPYSKVGWNASDTRELSFTDVRVPAANLLGEQGRGYAQFLRILDEGRVAISALATGLAQGCVDESVKYAAERHAFGRPIGANQAIQFKIADMEMRAHMARVGWRDAASRLVAGEPFKKEAAIAKLYSSTVAVDNAREATQIHGGYGFMNEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ94</accession>
    <name>A0A7K2ZJ94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaK</name>
        <name evidence="10" type="ORF">GT040_24915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001163">
        <property type="protein sequence ID" value="MYW32422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030571022.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001163.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="617" mass="66244" checksum="F92C34298433C37D" modified="2021-04-07" version="1">MARAVGIDLGTTNSVVSVLEGGEPTVITNAEGARTTPSVVAFAKNGEVLVGEVAKRQAVTNVDRTIRSVKRHMGTDWKIEIDGKGFNPQQMSAFILQKLKRDAESYLGEKVADAVITVPAYFNDSERQATKEAGEIAGLNVLRIVNEPTAAALAYGLDKDDQTILVFDLGGGTFDVSLLEIGDGVVEVKATNGDNHLGGDDWDQRVVDYLVKQFANGHGVDLSKDKMALQRLREAAEKAKIELSSSTETTINLPYITASAEGPLHLDEKLTRSQFQQLTSDLLDRCKTPFHNVIKDAGIQLSEIDHVVLVGGSTRMPAVAELVKELTGGQDANKGVNPDEVVAIGASLQAGVLKGEVKDVLLLDVTPLSLGIETKGGIMTKLIERNTTIPTKRSEIFTTAEDNQPSVQIQVYQGEREIAAYNKKLGMFELTGLPPAPRGVPQIEVAFDIDANGIMHVAAKDLGTGKEQKMTVTGGSSLPKDEVNRMREEAEKYAEEDHARREAAESRNQGEQLVYQTEKFLKDNEDKVPADVKTEVETAVGELKEKLKGEDTAEIRTATEKVAAVSQKLGQAMYANAQAEGATPGAEAPGDAQGKADDDVVDAEIVDDEKDTKGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJM8</accession>
    <name>A0A7K2ZJM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ORF">GT040_25565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509777.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001197.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="13305" checksum="2FC535782F426D0D" modified="2021-04-07" version="1">MSNPQQLRYSKEHEWLSAVEDGVATIGITEYAANALGDVVYAQLPEVGDTVTAGETCGELESTKSVSDLYSPVTGEVTAANQDVVDDPSLVNSAPFEGGWLFKVRVTEEPADLLSADEYTAFSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJQ9</accession>
    <name>A0A7K2ZJQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001201">
        <property type="protein sequence ID" value="MYW32590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="2">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="377" mass="39701" checksum="AAED8962A1417B45" modified="2021-04-07" version="1" fragment="single">MLYGRAAEQERLAGLLAEARAGRSGALLLRGEAGIGKTALLDWLAGTAAAPAEEGTTGDRGTTGDRRATGDGETAGDGREVRVLRVTGVEPEADLAFGGLVQLLWPVQDRLNALPAPQAAALRAILGTGREQRGPDRFLTGLAVLTVLAELAEDGPLLCLVDDAQWLDRATAEALLFAARRLAAEGVAMVLAGRDDDGFTAPGIPELTLPRLDFEDSSRLLADRGRAPALHSQIITESAGNPLALIEFDAARSDQPHQHAPLPVADRVSSAFRARIGGLPERTRLMMLIAAAEGRGDLPLLLRASELLGVDLGDLAEAERTGLMYVMDGAVTFRHPLIASATYQGAVLARRIAVHRALAEAATDPDCRARHLLAVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK11</accession>
    <name>A0A7K2ZK11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_26325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001225">
        <property type="protein sequence ID" value="MYW32692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="443"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="562" mass="56764" checksum="0F3933B54A7B640D" modified="2021-04-07" version="1" fragment="single">MTAPVNTSTWGRVRALLPVRADFVAMTRNPRRDLLAGLTVAIVALPLALGFGVSSGLGAEAGLATAVVAGALAAVFGGSNLQVSGPTGAMTVVLVPIVAEHGAGGVLTVGLMAGALLIGLALLRAGRSMRYVPAPVVEGFTFGIAGVIALQQVPGALGVAVPEGDKVLVVAWRAVREFAAHPDVTALSIAVGVAGVMLLGARRFPTVPFSVVAVALATVAVEVFGLGAEPIGALPAGLPAPSLGFLEVSALGSLVAPAVAVAALAALESLLSATVADGMTVGQKHDPDRELFGQGIANLAAPLFGGVPATAAIARTAVNVRTGASSRLAALAHAAVLAVIVFAAAPLVSRIPLAALAGVLLATAVRMVEVGALLAMARATRSDAVVLVLTATATLVLDLVLAVVIGLVVAGALALRAVAGEARMDRVDLREGGGTDLPGAHSEEEHALLAEHIVAYRIDGPLFFAGAHRFLLTLSEVADVRVVILRMSRVTTVDASGALMLKDAVHQLNRRGIAVLASGIRPGQRRALESVGALELLRREGREYATTPEAIAGARDRLREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK98</accession>
    <name>A0A7K2ZK98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 16" type="primary">guaB</name>
        <name evidence="16" type="ORF">GT040_26735</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="WWKE01001250">
        <property type="protein sequence ID" value="MYW32770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="101"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="344"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="367"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="391"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="255"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="304"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW32770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="500" mass="52511" checksum="DFDAC43BB4AF36F7" modified="2021-04-07" version="1">MTANVDGVPEKFATLGLTYDDVLLLPGASEVLPNAVDTSSLISRNVRVNIPLLSAAMDKVTESRMAIAMARQGGVGVLHRNLSIEDQVNQVDLVKRSESGMVTDPITVHPDATLGEADALCAKFRISGVPVTDAAGKLLGIVTNRDMAFESDRSRQVREVMTPMPLVTGKVGISGVEAMELLRRHKIEKLPLVDDAGILKGLITVKDFKKAEQYPNAAKDAEGRLLVGAAVGASPEALDRAQALASAGVDFLIVDTSHGHNRNALDWMAKIKSSVGIDVIGGNVATRDGAQALIDAGVDGVKVGVGPGSICTTRVVAGIGVPQVTAIYEAALAARAAGVPVIGDGGLQYSGDIGKALAAGADSVMLGSLLAGCEESPGELMFINGKQFKSYRGMGSLGAMQSRGQGRSYSKDRYFQAEVSSDDKLVPEGIEGQVPYRGPLANVLHQLVGGLRQTMGYVGAESVDQMESKGRFVRITSAGLKESHPHDIQMTVEAPNYSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKF5</accession>
    <name>A0A7K2ZKF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001254">
        <property type="protein sequence ID" value="MYW32808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029544822" evidence="1">
        <location>
            <begin position="35"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="63"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="349" mass="36823" checksum="A05B76150DE34BCE" modified="2021-04-07" version="1">MLSKATPAPIRTAALFAAGVVLLTACGGGTTNSADGGGGKAEGFPLTLKNCGRTVTVKAPPQRAVSVDQGSTEILLSLGLADRLAATATWSDPVMKGLEKANEGVERISENRPSSEKVLDKEPDFLSASFASTLAKGGVAPREQFEKLGVPTYISPADCTGKDNSGGGDGARTAPLTMDSVYTEVRELSQVFGVPERGDALVKKLQARVAKATDGIDGSKASLLYWFSDSKAPYLAGCCGAPGVITRELGAKNVFDDTHDEWPQISWETVADRNPDVLVIGDLSRTTQTAESAEKKIEFLESNPVTKTMDAVKNRRYVLLSGQAMNPTIRTVEGLERVAAGLREFGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL62</accession>
    <name>A0A7K2ZL62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001312">
        <property type="protein sequence ID" value="MYW33081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="63" mass="6810" checksum="7C799D256FB05633" modified="2021-04-07" version="1">MSLSDIREMGFTGLSPEQEERVVGGATKAQCIQWAAMIASGGAGLSAGHQNYLNLYNKYCKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLF4</accession>
    <name>A0A7K2ZLF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001350">
        <property type="protein sequence ID" value="MYW33187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="35743" checksum="8ACFB8140DEF379C" modified="2021-04-07" version="1">MKYTQLGRTGLKVSRLVLGTMNFGPQTNESDSHAIMDAALGAGLNFFDTANVYGWGENKGRTEEILGTWFAQGGGRRDKVVLATKMYGNMAPEGDAWPNHDKLSAVNIRRAVDASLKRLQTDHIDVYQFHHIDRNTPFEEIWQAIDVLVQQGKILYAGSSNFPGYKIAQANEQAARRGSLGLVSEQCLYNLAERRAEMEVIPAAQDYGVGVIPWSPLHGGLLGGVIKKEAKDGRRASGRSADALANSTVRAQVQAYEDLLEKHGLEPGEAALAWLLTRPGVTGPIVGPRTAEQLESALRALELELPEAVLTGLDEIFPGPGPSPEAFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLW0</accession>
    <name>A0A7K2ZLW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001380">
        <property type="protein sequence ID" value="MYW33337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="84" mass="8742" checksum="F9031B94D7726F7A" modified="2021-04-07" version="1" fragment="single">MRRAYSVETVRAAEAALMKRVPEGVLMQRAAAGLAAACGDLLRRTGRVYGSRVLLLVGSGDNGGDALYAGARLARRGAGVRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM06</accession>
    <name>A0A7K2ZM06_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">topA</name>
        <name evidence="11" type="ORF">GT040_30045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001388">
        <property type="protein sequence ID" value="MYW33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="184"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="883"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="912"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="961" mass="104073" checksum="E2F3E5B840AD6CE4" modified="2021-04-07" version="1">MSPTSETAQGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPDEYTGEVRRLGVDVENDFQPIYVVNADKKAQVRKLKQLLAESDELFLATDEDREGEAIAWHLQEVLRPKVPVHRMVFHEITKDAIRAAVANPRELNQRMVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGKFATGRTGDASDPSTLTARLSAVDGRRIAQGRDFGADGQLKAGSAQTLHLDEVNARALAAALADTSFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSDTAVAAARAQVTQLYGANYLPEKPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIWKRTVASQMKDATGNSVTVKIGGRASDGRDAEFSASGKTITFHGFMKAYVEGADDPNAELDDRERRLPQVAEGDALSAEEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQSVPWLKRFYFGAQPGDDTAGAGAASDAGNGDGDHLGGLKELVTDLGAIDAREISSFPVGNDIKLRVGRYGPYIERGEKDAEGHQRADVPEDLAPDELTVELAEELLAKPSGDFELGADPVSGNQIIAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLADALKLMSLPRVVGEDAEGVEITAQNGRYGPYLKKGTDSRSLTSEDQLFDITLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSGSPVVVKDGRFGAYVTDGETNATLRTGDSVEEITPERGYELLAEKRAKGPAKKKTAKKAPAKKATAKKTAAKKTTATKTTAAKKTAAKKTATKSTAAKKTATAKKTASASASASASSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM69</accession>
    <name>A0A7K2ZM69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LD-carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_30240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="5">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="6">
        <location>
            <begin position="208"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="36774" checksum="533664CB299C2CFF" modified="2021-04-07" version="1">MSVRYPRPLRPADRVGVTSPSSGVPKELQGRLDVAIREVEAQGYEVVVGRCMSGDGHVSAPAAERAAELTAMLTDPGIRAVVPPWGGETAIDLLPLLDWDRLREAEPTWLVGFSDLSTVMTPFTLLTGTATVHGNNLMDTPYRAPEGLSSWLDITSAPVGHRFTQIPPGRHRATGWDDYRTRPDVRAFTLDTPARWTRLDGEGDVEAEGRLIGGCIEMLCNLAGTDFLDISAFARAESPQGLLVYVEAGGDDAFTICRNLHGMRLAGFFDTANAILVGRTTAPGTDSLTQHEAVLDALGSLNVPIIADVECGHVPPYLPIVNGARGRVVHTGTRSELTQTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZME9</accession>
    <name>A0A7K2ZME9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ComEA family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001425">
        <property type="protein sequence ID" value="MYW33535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="5862" checksum="62DBF4F0CCF09387" modified="2021-04-07" version="1" fragment="single">MAPRTLAALAVVLVAAVGLAAFHFWSVRPQGVRAPETVEAGAAAVAGDPLRATGADPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMR4</accession>
    <name>A0A7K2ZMR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6650" checksum="C9513995C4B9E782" modified="2021-04-07" version="1">MAAAAPAVGPAPSGCQHCGIDQREHMQRWKTGAGWHKWTAPTQDQIKTRMLARRAARRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMS7</accession>
    <name>A0A7K2ZMS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="53" mass="6490" checksum="8623A446604AB481" modified="2021-04-07" version="1">MARQRGKVRSRAQWRWMYAAKMPFRKSWSRARKRSHGKTTGYRTLPARRSTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN40</accession>
    <name>A0A7K2ZN40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dnaE</name>
        <name evidence="11" type="ORF">GT040_31540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001442">
        <property type="protein sequence ID" value="MYW33679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="10">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW33679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1178" mass="130888" checksum="C548C1BE9E7B0B4A" modified="2021-04-07" version="1">MTKPPFTHLHVHTQYSLLDGAARLKDMFEACNEMGMSHIAMTDHGNLHGAYDFFHSATKAGVTPIIGIEAYVAPESRKHKRKVQWGQPHQKRDDVSGSGGYTHKTIWASNKTGLHNLFRLSSDAYAEGWLQKWPRMDKETISQWSEGLIASTGCPSGEVQTRLRLGQFDEAVQAASDYKDIFGADKYFLELMDHGIEIERRVRDGLLEIGKKLDIPPLVTNDSHYTYAHEATAHDALLCIQTGKNLSDPDRFRFDGTGYYLKTTDEMYAVDSSDAWQQGCANTLLVAQQIDTTGMFEAKNLMPRFEIPDGFTEITWFQEEVRKGMQRRFPSGVPDDRQKQVEYEMDIIIQMGFPGYFLVVADFIMWAKNNGIAVGPGRGSAAGSIVSYAMGITDLDPIEHGLIFERFLNPERVSMPDVDIDFDERRRVEVIRYVTEKYGADKVAMIGTYGKIKAKNAIKDSARVLGYPYAMGDRLTKAMPADVLGKGIDLNGITDPKHPRYSEAGEIRGMYENEADVKKVIDTAKGVEGLVRQMGVHAAGVIMSSEPIVDHAPVWVRHTDGVTITQWDYPQCESLGLLKMDFLGLRNLTIMDDAIKMVKSNKGIDLEMLALPLDDPKTYELLCRGDTLGVFQFDGGPMRSLLRQMQPDNFEDISAVSALYRPGPMGMNSHTNYAERKNGRQEITPIHPELEEPLKEVLGLTYGLIVYQEQVQKAAQIVAGYSLGEADILRRVMGKKKPEELAKNFVLFEKGAKEKGFSDAAIKALWDVLVPFAGYAFNKAHSSAYGLVTYWTAYLKANYPAEYMAALLTSVKDDKDKSAVYLNECRRMGIKVLPPNVNESLSNFAAQGDDVILFGLTAIRNVGQNVVDSIIRSRKAKGKYSTFPDFLDKVEAVVCNKRTVESLIKAGAFDEMGHTRKGLVAHHEPMIDNVVQVKRKEAEGQFDLFGGGEEESGEPGFGLDVEFSDVEWEKAYLLAQEREMLGLYVSDHPLFGLEHVLSDKADASISQLMGGDYSDGSIVTVGGIISGLQRKMTKQGNAWAIATVEDLAGSIECMFFPATYQLVSTQLVEDTVVFVKGRLDKREDVPRLVAMEMQVPDISNAGTNAPVILTIPTVKITPPMVTRLGEVLSHHRGDTEVRIKLQGPRKTTVLRLDRHRVKADSALFGDLKVLLGPSCLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN42</accession>
    <name>A0A7K2ZN42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001452">
        <property type="protein sequence ID" value="MYW33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029808463" evidence="2">
        <location>
            <begin position="41"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="445" mass="48296" checksum="43D8269FA32FE30F" modified="2021-04-07" version="1">MSEPHEGRRRPPRRRSVLAAAGAGLGTALAGSLSACSASGDSAGSGVTLTFSWWGNEDRAARTTQAVRLFEKENPRVRVRTSNADFGSYMQKLATQAAGGGIPDVAQLDYRQVSQYAGGGALLRLGGAVRDGTIRTAEMDADFLRTGTYEDEQYAVPMGRGITGFAYDTRLYRKAGAAAPEPGWTWQEWAEVSRKIARLRERSPDGRPVAGANDGGVNEDVFEVWLRSRGGRLYASQTRLGFTEDDLTEFWTLCDELRKEGAAARAEDTSQATSTETSPMGRGLAAADFTWDAPFPGYPALLGDHVHFAPVPTTGGKQGAYFKPSMLLGVGAHTPHPGEAARLVDFLLNDPRAGDILGFSRSTPPNRTVAARVARTLKGAERDIYRYARRMEEYGLDAPPTAPPRGDVAIQTAFNRTYQRVMYGLASPREAARELIDEAKRELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNB7</accession>
    <name>A0A7K2ZNB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_32280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001484">
        <property type="protein sequence ID" value="MYW33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="256" mass="28208" checksum="999028E92BAA242F" modified="2021-04-07" version="1">MSVAESGGAQVKSAVRTVELLEYFAGRPGMHSLAAVQEAVGYPKSSLYMLLRTLVELGWVETDATGTRYGIGVRALLVGTSYIDGDEVVAAARPTLDRLSDDTTETIHLARLDGTNVVYLATRQSQHYLRPFTRVGRRLPAHSTSLGKALLATHSDEQVRKMLPETLPSLTEHTITDREKLIEELRLVREQGYAVDREENTLGLRCFGVAIPYRTPARDAVSCSVPVARLTPGHEQTVKDALLDARDRLTLATRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNC3</accession>
    <name>A0A7K2ZNC3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nuoN</name>
        <name evidence="8" type="ORF">GT040_32455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001486">
        <property type="protein sequence ID" value="MYW33856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="184"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="554" mass="57100" checksum="4C4DEA89501E2199" modified="2021-04-07" version="1">MSATAVHSLWTTASGVTSAAPGDRFTAPTIEYAQLAPVLIIVIGAVLGILVEAFVPRKARYHAQLLLTVVALAAAFAAVVSLAAGGYATTKAQIAAMGAIAIDGPTLFLQGTILLVAVVAVFTFAERRLDPTAHGNRVDSFAAQAGTVPGSDAEKAAVRAGFATTEVFPLTLFSVAGLLVFPAANDLLTLFIALEVFSLPLYLLCAVARRKRLMSQEAAVKYFLLGAFSSAFLLFGIALLYGYAGSLSYATIANVVDGSVLEIDPALAGTMGNDALLLIGGALILVGLLFKVGAVPFHMWTPDVYQGAPTPVTGFMAAATKVAAFGALLRLLYVVLPGLTWDLRPVLWAVAIITMLGGAIVAITQTDIKRLLAYSSIAHAGFILAGVIATSPEGVSSVLFYLGAYSFVTVGAFAVVTLVRDAGGEATHLSKWAGLGRRSPLTAAVFAVFLLAFAGIPLTSGFSGKFAVFKAAAESGAGALVVVGVISSAIAAFFYIRVIVLMFFSEPKADGPTVAVPSPLTMTTIAVGVAVTLVLGLAPQYFLDLAGQAGVFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNP7</accession>
    <name>A0A7K2ZNP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001506">
        <property type="protein sequence ID" value="MYW33975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9806" checksum="8E3927E819F18034" modified="2021-04-07" version="1">MHMIALRLDVPPGEHVAPADVTALLRVHFVPDDRIEHLWAHSATGSVDLAFFLLADIEAEALLTARAACQRAIERTPRFTHWRLRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNQ1</accession>
    <name>A0A7K2ZNQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001512">
        <property type="protein sequence ID" value="MYW33994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-oxidase_C" evidence="2">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="189"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="376"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="600" mass="65455" checksum="C912DA622731F637" modified="2021-04-07" version="1">VTDPAGQRALWRIREDASGTATRMPDGTEAWPGWEDCAVPPARLGPYLRDFRALLAQHGLRGTPYGHFGDGCIHVRIDFDLLTPAGVSRFRRFSEELADLVVTHGGSLSGEHGDGQARAELLPRMYGDELVGLFGRFKDLWDPDGGLNPGMLARPARLDENLRFDVLPRRPVDVAFGYPQDGGDFAGAVRRCVGVAKCRTETAPGAGVMCPSYRVTGEEAHSTRGRARLLHEMLAGEVITDGWRSTEVRDALDLCLSCKGCRGDCPVGVDMATYKAEFLHHHYRGRLRPAAHYALGRLPQWLRLARPFAVLLNALARVRPLAGLAKRLAGITPERTIPELATETYSRWLRGRQGKGTHIVSSSRVVQVWADTFTEHLSPQVGRAAVRVLEEATGRTVLPPPSKVCCGLTYVSTGQLDAARAVMRRTLDRIGLLPGHPLVVLEPSCAATLRTDLPELLPDDSRAHELASSVRTLAQYLEEYAPDWAPPRLDRPAVGQTHCHQHAVLGDAAERRLRERMGLTGELSGGCCGLAGNFGFEKGHWEVSVACAEEQLLPAVRKSEPGAEVLADGFSCRTQLDQLAGRRARHLAEVIAEGLGDGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPF6</accession>
    <name>A0A7K2ZPF6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lant_dehydr_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001569">
        <property type="protein sequence ID" value="MYW34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="175"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="414" mass="45525" checksum="D9E1A52FF1B13262" modified="2021-04-07" version="1" fragment="single">WVSWRLEVPSGARPDRELRAVLERVGDAELRRGALEPLEVLERGRERVEAAGRDAEALCGALAALEEDFTRITDTASQRAKGSGTAPNRSLVYSDTRRSATARVGGTVLEAMAPLDPLMTSAAWLMAQLGARVERRAVEVYEKLSAASGEDRVNLADFWFACMPILHGGAVTDAQEVLTEFQRRWARIIPLPEGEARVRATHSSVASQVAEEFPPAPVAWAAARYLSPDVLIAARDTESIGGGDFELVLGEMHLASNTMGASLFVSQHPEPAELLRLTGRDHPGPRLLPLLPKEHKARLSTRVRNVLVRPEDYYVALMELTADPHRDRTVLSADAHVVRRDGRPVVVLPGGAEFPVTDVFGHVLTTLAMDMFRLFPDADHVPRVMVDKLVVSRESWRFTGGDLGFAEEKSEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPL5</accession>
    <name>A0A7K2ZPL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001577">
        <property type="protein sequence ID" value="MYW34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="11735" checksum="F1A49E36D3307940" modified="2021-04-07" version="1" fragment="single">HAHGLPGEPFTAGPPSALALCAGIDLPSSHRTAAALWACEHPAELDGQELDGLVQTLAAPRQEAAVPAAETAALADLFARVGGNLRPETAAPLAARLLTAAVRSDEPVRPPDPGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ69</accession>
    <name>A0A7K2ZQ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_35895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001631">
        <property type="protein sequence ID" value="MYW34516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="220" mass="24071" checksum="28CFE5E1F0A403FE" modified="2021-04-07" version="1">MRVLLVEDDDDLRAVLAAGLRDAGFAVDGADDWPEADVMLHVTAYDCVVLDRMLPSGDSLARLESRRRSGWSVPVLCLTALDGLDDRVRGLESGADDYLAKPFAMRELVLRVRSLTRRAAERLPAFLSCAGVVMDLARREVRRGGVLLSLSPKEYAVLQQLLVHRDSVVTRTALLEHCWDEMADPVSNVVDAVIAGLRRKLGTPSLVHTVRGQGFLLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQR1</accession>
    <name>A0A7K2ZQR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_36905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001680">
        <property type="protein sequence ID" value="MYW34711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="31772" checksum="9BCD0CC1DD070275" modified="2021-04-07" version="1" fragment="single">MTATGADREAAGSTTRGYWWWERRRSVALDVGLALVSALECGLEGVEFAGNTGLPVSVGVVFGLLAGSVLVVRRRWPIAVVLVSIAMTPAEMGFLMALVGLYTLAASEVPRRITVVLAGMALVGTFIVTYVRLRQTVAEDADFGPGDWYVPLVSVFMAVGLTAPAVLFGLYIGARRRLMESLRERADSLERELSLLADRAEERAEWARTEERTRIAREMHDVVAHRVSLMVVHAAALQAVAPKDPAKAVRNAALVGDMGRQALTELREMLGVLRSGDALIAPVAAGGGAVPLAAVGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQT7</accession>
    <name>A0A7K2ZQT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001682">
        <property type="protein sequence ID" value="MYW34734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="19443" checksum="A01722A21D792FD8" modified="2021-04-07" version="1">MQTSALPDLAHTATKPVHWLATAVAMAGVVALAGLLQPRTATATATAPEKRTTTPVAAPDPATVDFPLECGGAGTTVAKQAPGDLDGDGRPETVAVVHCDAGSGTPPSGIYVLTQRSGAAPRVVATLVDPADRKTVGDFAVREGRVSATLLGYSSLQVPRCCPDQEEQASWRWKGNAFVRTSGDLARSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQX8</accession>
    <name>A0A7K2ZQX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmF</name>
        <name evidence="6" type="ORF">GT040_37125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001683">
        <property type="protein sequence ID" value="MYW34752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="6462" checksum="894C4E8D559F7C95" modified="2021-04-07" version="1">MAVPKRKMSRSNTRHRRAQWKATTPQLVPVTIEGTVHQVPQRLVKAYERGLIRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQZ6</accession>
    <name>A0A7K2ZQZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonspecific lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_37365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001689">
        <property type="protein sequence ID" value="MYW34800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="108"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="378"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="501" mass="52493" checksum="2DE27192315CD80F" modified="2021-04-07" version="1">MHRAAHHPPAGLRPRTGRRGLGAQARPDRPPAEGRRAHPRTPGPGRGGGRTGGGGASPARLPDVPLPDHRGRHHPDPAERRRRADPRPPPGLTPPNEEVERTRNMTAYIVGVGMTKFEKPETRDWQYWDMVREAGTAALEDAGVRYDQVEQVPVGYCFQASTAGQRAVYELGLTGIPVYNVNNNCATGSTALMLARQFVEGGAGDCVLAVGFEKMARGSLGGGSGGSGDFAASPVARHYGVMAAAHGFEMSPPTVQIFGNAAREHMERYGTTPAQLAAVGAKNHRHSVNNPYAQFQDPYTVEEVLAARTVHDPLTKLQCSPTSDGAAAAVVVSERFVEAHGLGERAVEIAAQAMTTDTDASFASGTCIDAVGAPMSRAAAEQVYAASGLGPGDLDVIELHDCFSINELLTYEALGLCGEGESGKLVESGATTYGGRWVVNPSGGLISKGHPLGATGIAQAAELTWQLRGEAGPRQVPGARIGLTHNIGLGGAAVVTLLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR46</accession>
    <name>A0A7K2ZR46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="10467" checksum="8A753C69464990FE" modified="2021-04-07" version="1">MPGQRRRRRQPPGEPRPSAGRFAPEAGHWSVLFETQDASERHAYVRRLRAEGSRIDWSAVRLDTLCGRLKQPTTYRLSLFVPNSGPGPEGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS09</accession>
    <name>A0A7K2ZS09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001780">
        <property type="protein sequence ID" value="MYW35146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="46" mass="4768" checksum="015928E8474AFFB7" modified="2021-04-07" version="1">FERVPGSGQGLIGLTERATLAGGRLEHGPTPDGGFVVRARLPWPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSK2</accession>
    <name>A0A7K2ZSK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29955</name>
        <name evidence="2" type="ORF">GT040_39485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001386">
        <property type="protein sequence ID" value="MYW33376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001789">
        <property type="protein sequence ID" value="MYW35199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="137" mass="14731" checksum="D286858291EADACA" modified="2021-04-07" version="1">MTEPTSSASVRRISTGAPWEEKFGYSRAVELPNGLVLVAGCTSVVNGQIAAGSPYEQTITAFDVAFAALEQVGLTREDVVRTRMYITHARDVDDIGRAHKELFDAVRPAASMIIVSGFVDPSLVVEVEIEAYRGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSN2</accession>
    <name>A0A7K2ZSN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="33"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15438" checksum="0FE167286C93C5D3" modified="2021-04-07" version="1">MFRRQFSSNPRGARLARRVGLYRLHAWGIPYLSDASESAALIIGELTANAATHGRIPGRDFELRLTHAPGDRQVPGVLRIEVSDTRGECRPPGPGEITAPADGDDSGRGMLIVDALADRWAVLDRERPPGKTVRAELDLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSN6</accession>
    <name>A0A7K2ZSN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001833">
        <property type="protein sequence ID" value="MYW35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="9510" checksum="643E811E69158570" modified="2021-04-07" version="1" fragment="single">MQSVTLPASLDEAVAALEAMPAAVPVAGGTDLMAAVNKGLLRPSGLVGLGRISELRGWHYQDGHALLGAGLTHARMGRPDFAALIPALAASARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSR7</accession>
    <name>A0A7K2ZSR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_40295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="345"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="627"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="759"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1375" mass="148845" checksum="D2A74CBE11A0478E" modified="2021-04-07" version="1">MDEVFTADRNIGRELAKVDWSATPLGEPEDWPQSLRTAVSILLSSKFAMWMAWGPELTFFCNEAYRRDTLGQKYPWALGRPFATVWSEIWDDIAPRIDTVLNSGEATWDEGLMLFVERSGYTEESYHTFSYSPLRDEGGAVVGVLCVVSEDTKRVIGDRRMATLRDLGSDPSVIRTEQEMLDFAGEQLSRNPYDLPFTLTYLFQDDGSARRVSVTGLGTAHPAAPDILPLDAVSLWPVDVPARGDSVLVPLDGEPFTGLPTGAWGEPPIQAMVVPLLQQGGTPYGFMVAGLNRFRALDEDYQGFLDLVAGHMAAGVASARSYQAQQRRAEELAELDRAKTTFFSNISHEFRTPLTLIMGPVQELREQLADADQRVREELEAVHRNGLRLGKLVNTLLDFSRLEAGRMQASYEPVDLATVTGALASVFRSAVENAGLDFRVECEPLPEPVYVDRGMWEKVVLNLLSNALKFTFEGSIRVGVGAQDDEAVVRITDTGIGVAAEEMPRLFERFHRIENARSRSNEGSGIGLALVKELVGLHGGVITAASSEGEGTSFTIRLPFGSAHLPADAVRTHGGDDVISPGAAAPFVQEALRWLPGGQTGVPAGEARSGPQTAGEAPAAPLSAQARVLIADDNADMREYLTRLLRDAGYRVDAVVDGQQALEAVRADAPDLVVSDVMMPRLNGLSLVRALRTDSRTASVPVVLLSARAGQEASIEGLQAGADDYLVKPFAAAELLARVEANVKLARLRNHHARWRTALIDSLQEAFFVCDGDGAVIEINTSFTGILGYGPEDLPYEPVHPWWPDAATDPEAHRLVAGAFATLTGQERGSYTIPVTHRDGHRLWVTATFNRVQDPDSGRTVIVGTLRDVSAEHYAIQRDTALAALSTRLSQAASLAEALEGSLEELKKLWRAQHVTAVVFGPRDEPALTGTDTGLVWQDLPAERRRMLTGLRDQPALTAVPGQGGATVVLEHPQGILALWIALGEQRPFTDEDQLLLSLLAGRLAQGLARAHQIDQQRETAIALQRAILGPSQLPDGFAVRYEPATRPLEVGGDWYDTVALPDGRIGIVVGDCVGRGLEAASVMGQLRSACRALLLQDAGPARALMALDQFAVGVPGAMCTTVFCGVLDPRTGQLIYSSAGHPPGILVRPDGATRLLEDGRSLPLAVRPDRPRPESSCTISARSTLLLYTDGLVERRRRPLSAGIDRAGEALQDGRDTAVDDLASDVMSRLAPDGGYDDDVALLLYRHPAPLEISFPAESGQLAPVRRALRGWLEQCDLPPHTAQSVLVAAGEACANAIEHGHRDAPGDTVYFRAEASVDNLRLTIADTGRWKVPQPERNAHRGRGMGLMRALMQQVTVVQGPTGTTVDMHTRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZTA3</accession>
    <name>A0A7K2ZTA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001851">
        <property type="protein sequence ID" value="MYW35439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14393" checksum="DC4559EB762AC2A8" modified="2021-04-07" version="1">MGMDLARVGSKVVELVSDGITYTVATAKLGMASIAMFALSEAVRGAYNYVEDCAKSVDTLADTASTLWVEGDVVNAHRDAAAVMRGVLADAESLANEAEEMAADFKSAKEGHEADYGPVAELMAGKDTDRSYYSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5T6</accession>
    <name>A0A7K2Z5T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lasso peptide biosynthesis B2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16618" checksum="A286ABE5A5318E73" modified="2021-04-07" version="1">MTTEMTMPRRGAGPGGVRLRAAIAAAFVLARFKPGRLRRVLTRCARGARPATYEETLEMYEAVTATSRRCAGRYGCLPRSVAIALACRMSGSWPDWCAGVRTAPPFSPHAWVEAEGRTVGEQAESADLRPLMVVTVREGVPGERGGGDDDGGGQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z657</accession>
    <name>A0A7K2Z657_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000021">
        <property type="protein sequence ID" value="MYW27827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="320" mass="35726" checksum="8A7B60BB76B8CF5C" modified="2021-04-07" version="1">MTAPSDPAPPSAPSAVPSPGGAPVPRGTGRLLAVSDLHVAVTDNRPIVESLHPTSDADWLIVAGDVAERPDDIRWALSLLAERFAQVIWTPGNHELWTLDKDPVQLRGQARYEHLVELCRGLGVITPEDPFPLWPGPDGPVAIAPLFLLYDYTFRAPGTHTKEESLAVAHESGIVCNDEYLLHPDPHPTRDDWCRARVAETERRLAAHDPEIPLVLAGHWPLVREPTSVMWYPEFAQWCGTELTADWHRRFNVTAVVYGHLHIPRTTWYDDVRFEEVSIGYPREWRERGHPRGLLRQILPYEAESTPSARTGTATSGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6I5</accession>
    <name>A0A7K2Z6I5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_01340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000059">
        <property type="protein sequence ID" value="MYW27950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="218"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW27950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="376" mass="41240" checksum="ED59FE71056ED5E1" modified="2021-04-07" version="1">MDFRTEVRAWLDSHLADTPTPDPRAWERELGQAGWIGIGWPPGKDGRTYGNRPAPLTHQVIWAEEYARSTAPPRMGHIGENLLAPTLIAYGTEEQRRRHLPSIARGETLWCQGYSEPGAGSDLAGIRTTATPDTTTGGYTVTGQKIWTSLARDADWCFVLARTEPGSTRHHGLSFLLVEMDQPGRIEVRPIRQMTGTSEFNEVFFDGARAAEAVGGEGNGWAVAMGLLALERGVSTLAQQIGFAQELDQVIAAARATGAAEDPVLRARLVRQWAELVTMRRHALRTLGTPGDPGAPSVAKLLWGGWHQRLGELAVEVRGEAGAVGPQPWSPWHPYELNTAQHLFLFTRADTIYGGSDEIQRNIIAERVLGLPREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6N4</accession>
    <name>A0A7K2Z6N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AarF/ABC1/UbiB kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000068">
        <property type="protein sequence ID" value="MYW28004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="93"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="488" mass="53040" checksum="7FD3AA61D7083D87" modified="2021-04-07" version="1">MSDLPRKAVTRTAKLAALPLGFAGRATWGLGKRIGGRSAELVAREVQQRTADQLFKTLGELKGGAMKLGQALSVFESALPEEIAGPYRAALTKLQEAAPPLPAATVRAVLAERIGEDWREYFLEFEDKPSAAASIGQVHRGVWHDGREVAVKVQYPGAGEALLSDLTQLSRFARLLGPLVPGMDIKPLIREMRDRVSEELDYELEAEAQRVHAEEFADDPDVVIPGVVHQSDQVLVTEWMDGVPLADVIAEGTPEQRDRAGQLLARFLFSGPARTGLLHADPHPGNFRLLPAEAQEEASENPDGSDEEGAEAGEWRLGVLDFGTVDRLPGGLPGTIGESLRMTLEGDAAGVYGLLRAEGFVKESIDLEPDEVLDYLLPIIEPAQVEEFAFSRGWLRDQAARIADPRSPAHQLGRQLNLPPSYLLIHRVTLSTIGVLCQLGAAVRLRDELEAWLPGFVAEAEEAEGSEEPVFRPEIREPEPESVPEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6X0</accession>
    <name>A0A7K2Z6X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speB</name>
        <name evidence="5" type="ORF">GT040_02075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000099">
        <property type="protein sequence ID" value="MYW28090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="35165" checksum="4CE42693DC363343" modified="2021-04-07" version="1">MSSNESPRGPVDSSRVPRYAGPATFARLPRLDEVGRADVAVVGVPFDSGVSYRPGARFGGNAIREASRLLRPYNPAQDASPFALAQVADAGDIAANPFNINEAVETVEAAADDLLDTGARLMTLGGDHTIALPLLRSVAKKHGPVALLHFDAHLDTWDTYFGAEYTHGTPFRRAVEEGILDTSALSHVGTRGPLYGKQDLTDDERMGFGIVTSADVMRRGVDEIADQLRQRIGDRPLYISIDIDVLDPAHAPGTGTPEAGGLTSRELLEILRGLSSCHLVSADLVEVAPAYDHAEITSVAASHTAYELTTIMSRQIAAQKDAKDTEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Y6</accession>
    <name>A0A7K2Z6Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000099">
        <property type="protein sequence ID" value="MYW28088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="14022" checksum="2BFCE96AFAA77DAD" modified="2021-04-07" version="1" fragment="single">MDEPSMPTPPTPSPGPPTPPIPLAELLARKDLGLRRIAGPAEADLLWVHTSEMADPYPYLLGGELLLSAGVLLTDPDRYVARLVEAGAAALGFGVRPVYEAVPEALVEACDRYGLPLLEVPPETPFTTIARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z708</accession>
    <name>A0A7K2Z708_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nrdR</name>
        <name evidence="10" type="ORF">GT040_02140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000100">
        <property type="protein sequence ID" value="MYW28102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18585" checksum="345E2FFC49B4E943" modified="2021-04-07" version="1">MHCPFCRHADSRVVDSRTTDDGTSIRRRRQCPDCSRRFTTVETCSLMVVKRSGVTEPFSRTKVISGVRKACQGRPVTEDALAKLGQRVEEAVRATGSAELTTHDVGLAILGPLQELDLVAYLRFASVYRAFDSLEDFEAAIVELRAQRPTAEDCGSGETLEVPAPAIAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z758</accession>
    <name>A0A7K2Z758_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000111">
        <property type="protein sequence ID" value="MYW28189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="9705" checksum="6E0A188FA8232A80" modified="2021-04-07" version="1">MTLEVGGTGKVAVMYNAASSGFEEQSLPWTLTETVELTAAEKRVGYLVTAVPGTITAADGSLQQAPCVIKVDGKKVADNDAGKNPKGCTFTIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z761</accession>
    <name>A0A7K2Z761_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000111">
        <property type="protein sequence ID" value="MYW28186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029074">
        <property type="entry name" value="Imm49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15575">
        <property type="entry name" value="Imm49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="29301" checksum="000A57B44F8813E9" modified="2021-04-07" version="1">MLENSMESLIDGLEVDSTRLGDAFQLSLTLAKSHCLLDAEASRLPTWQAWVNAMQVGSATFATTTAPGGEIRCRIAEEERVLQATGPQRYSNPGAWMTAFYLAVICREKDRLTTLCQVPVPLLRESGAPCDEFVYSWVETLQAYWLGGPDLGTKLVAALDGTAPQSSHISAPETTAKLLYPPMEIFHRLVREDHAGFNRALAESIRWHKEYWSTEENALQATGLVALAPLAMTCLAYDASFSIEVTSEYLPIALLERDWPGEYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z776</accession>
    <name>A0A7K2Z776_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_02515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000110">
        <property type="protein sequence ID" value="MYW28172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029622983" evidence="2">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylas" evidence="3">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="7470" checksum="B1713C52D12D2277" modified="2021-04-07" version="1" fragment="single">MGSANGRHRRPRQAPAIVVAAGVTGSAIAIPLLGAAGAHAADATTWDRVAECESGGMWSADLGNGYYGGLQFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7U8</accession>
    <name>A0A7K2Z7U8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000161">
        <property type="protein sequence ID" value="MYW28430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="7498" checksum="8CC9A0094D0032AC" modified="2021-04-07" version="1">ASIAQQLQGSGSAQLALAPYLVGPEVDPGLLDAAAKEAGCATAEPLGAYPAIGKLVLSLYATALGITPATPQGAQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z890</accession>
    <name>A0A7K2Z890_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000198">
        <property type="protein sequence ID" value="MYW28533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="164" mass="18011" checksum="C9211C2FB2A3B294" modified="2021-04-07" version="1">MAAPQPARLASPSREPEAGGRDRYFAKLAQERPDVALCRATTLVTRALDEELAGRRLTMAQHLVLKMLSDVGPCSQQELSEQLRIDRSVMVGCIDGLEDSGLVRRERHPRDRRAYAVTLTPDAAPVLEEAESGVPHLLDRAFGALTAAERRTLTRLMGKILDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8B9</accession>
    <name>A0A7K2Z8B9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GT040_04575</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000202">
        <property type="protein sequence ID" value="MYW28562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="296"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="388"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="480"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="572"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="664"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="756"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="848"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="940"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="1032"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="1347"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1690"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1593"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1644"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1261"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1597"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW28562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1810" mass="193873" checksum="A6D57B1FE087E3F7" modified="2021-04-07" version="1">MKKQRNGTVEVDAAALNRLLAGLAAMRDGNFRRRLTVSGDGVMTEIAAVFNEVADRNLHLTGELARVRRVVGREGKLTERLETGALEGSWAAAIDASNELVDDLARPVSEVGRVLSAVADGDLEQRMELRSHTTDETVRPLRGEFLKVARTVNNLVDQLSVFTEQVTRVAVEVGTEGKLGGQAQVRGMSGSWKDLTDSVNTMAYRLTAQVRDIALVTTAVAKGDLSRKVTVHVAGEMLQLKNTVNTMVDQLSSFSSEVTRVAREVGTEGELGGQATVPGVAGVWKDLTDSVNTMAGNLTSQVRGIAEVTTAVASGDLTQKVTVSARGEVAQLAETINQMTETLRTFADEVTRVASEVGGEGLLGGQAQVPGAAGTWKDLTDSVNTVFRNLTTQVRDIAQVTTAVASGDMSQKVTVDVAGEMLELKNTVNTMVDQLQSFGSEVTRVAREVGVEGRLGGQAEVPGAAGTWKDLTDSVNTAFRNLTGQVRDIAQVTTAVANGDLSQKVTVDVAGEMLELKNTVNTMVAQLSSFADQVTRMARDVGTEGRLGGQARVDGVSGTWKELTDSVNFMAGNLTSQVRQIAQVTTAVARGDLSQKIDVDARGEILELKNTINTMVDQLSAFADQVTRVAREVGTDGRLGGQAQVPGVAGVWRDLTDSVNGMAGNLTAQVRNIAQVATAVARGDLSQKIDVDARGEILELKNTLNTMVDQLSNFAEQVTRVAREVGTEGILGGQAEVQGVSGTWKDLTQSVNGMANNLTLQVRNIAEVTTAVAKGDLSKKITVDAKGEILELVTTVNTMVDQLLNFADEVTRVAREVGTEGILGGQARVRGATGIWKDLSDNVNLMANNLTSQVRNISRVSSAVANGDLTKKVTVEARGEVAELADTVNTMVTTLSSFADEVTRVAREVGTEGELGGQARVPGVSGTWKDLTESVNSMASNLTGQVRQIATVTTAIAKGDLTKKIDIDARGEILELKNTINTMVDQLSSFADQVTRVAREVGTEGQLGGQARVRDVDGTWRDLTESVNEMAGNLTRQVRAIAAVATAVTRGDLNLKIDVDAAGEIQVLQDNINTMIANLRDTTLANKEQDWLKGNLARISGLMQGRRDLDDVASLIMSELTPVVSAQHGAFFLAMSPGDSDEVGPDHADDNAYELRMRGSYGYSAGSMPTSFRPGETLIGTAAEEKRTIQVDNVPPGYLKISSGLGEAPPAHVIVLPVLFEGKVLGVIELASFQPFTHIQRDFLNQLAEMIATSVNTISVNTKTEKLLEQSQELTEQLRDRSQELENRQKALQASNAELEEKAELLAQQNRDIEVKNTEIEEARQVLEERAEQLAVSMRYKSEFLANMSHELRTPLNSLLILAKLLADNAEGNLSPKQVEFAETIHGAGSDLLQLINDILDLSKVEAGKMDVSPTRIALVQLVDYVEATFRPLTAEKGLDFSVRVSPELPATLHTDEQRLLQVLRNLLSNAVKFTDSGAVELVIRPAGADVPNAIREHLLEAGSLRDADADLIAFSVTDTGIGIASSKMLVIFEAFKQADGTTSRKYGGTGLGLSISREIARLLGGEIHAASEPGRGSTFTLYLPLHRAELPPQGYPQVGSGSSEGLGGGSENGQGSPNGDSAPLGDPANSAGVFRRRRKALGEAARRPALPGGRPVAESVPQEEWVQANPAGTEEAPTPRRTFRFRGEKVLIVDDDIRNVFALTSVLEQHGLAVLYAENGREGIEVLEQHDDVTVVLMDIMMPEMDGYATTTAIRRMPQFAGLPIVALTAKAMKGDREKAIDCGASDYVTKPVDPDHLLAVMEQWMHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8F6</accession>
    <name>A0A7K2Z8F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RdlA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000211">
        <property type="protein sequence ID" value="MYW28603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029535290" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6138" checksum="1674DB35E084B5C8" modified="2021-04-07" version="1" fragment="single">MIKKVLATGAVAASILGLGSTQAMAIANDGGTTTVNGNGASQSYGNSETHGDWSPQFALIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8J1</accession>
    <name>A0A7K2Z8J1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rsgA</name>
        <name evidence="7" type="ORF">GT040_04865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000213">
        <property type="protein sequence ID" value="MYW28615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="99"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="5">
        <location>
            <begin position="118"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="158"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="209"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="338" mass="37022" checksum="924E0CE05AF4A61A" modified="2021-04-07" version="1">MRRYGKNPDEDDIRVRPNRKGNRPRTHIRPKHEDAEDGMVLTVDRGRLTCLVDGRTVVAMKARELGRKAAVVGDTVSIVGDLSGEKDTLARIVRIASRRTVLRRTADDDDPYERVVVANADQLAIVTALADPEPRPRMIDRCLVAAYDGGLTPLLVLTKSDLASPDKLLEAYTPLGVPYIVTNREELENGGAADRVREQLDGKITAFVGHSGVGKTTLVNALVPEDRRRTTGIVNAVTGRGRHTTTSALALPLPDGRGWVVDTPGVRSFGLHHVDPSRVINAFPDLQPGTENCPRGCTHDENQPECALDAWVAEGHADPARLDSLRRLLSTRERREGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8V9</accession>
    <name>A0A7K2Z8V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMI1/KNR4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="2">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="19941" checksum="112E0F2263DD06B2" modified="2021-04-07" version="1">MTDIDDLVQRVATRAASDADGLPAPADDARIAEAEAHLGFPLHPLLARLYGEVADGGFGPDYRLLPLLGPGSSVVGEYLERRQASVGAEHPEWPEGVVPILTWGCAMYAGVDCFSDDGQVLLFEPNPYSGGSWEECWFLDAAGLAAWLETWLAGTGWFEEDAFESEDVAEPQPWDQAADRLSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Y8</accession>
    <name>A0A7K2Z8Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family 16 glycosylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_05865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000256">
        <property type="protein sequence ID" value="MYW28809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001956">
        <property type="entry name" value="CBM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036966">
        <property type="entry name" value="CBM3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00942">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01067">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51172">
        <property type="entry name" value="CBM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029915890" evidence="2">
        <location>
            <begin position="41"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="CBM3" evidence="3">
        <location>
            <begin position="40"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="202"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="482" mass="51687" checksum="DC5A8878A1D3F96C" modified="2021-04-07" version="1">MNTSRRKHQRSRLRTAAASAAAVALAATGLAALPSSASAAADGIVVQYRTSASGASADQSEPWLKVRNAGSTSVPLSSVKVRYYFKADSASAAYRFACSWAVKGCANITGTFGTLANPTATADRYLEIGFTPGAGSLAPGADTGDMQLRFHQASWASLIQSDDYSFGPDRTTYGDWSKVTAQVNGSLVWGQAPSGNGPTDPPDPTDPPTDPPGDGARLFDDFNYSSHTDPKINANGWSVRSNSGGPGVPGATWAAENVTFASQSGNSVMNLETSTAGTGASTKHTEILTKSMKFKNGTYASRVKFSDAPRSGPDGDRIVQTFFTINDLKAPMAKDYAEYDFEYLPNGGWGEPANILYTTSWDTYRPDPWEAVNAHTESRRSYAGWHDLVVTIDNNQITYYVDGQHFGTHGAAFLPERPMSINFNQWLIDLEGQPSTTPRSYDQQVDYVLHVKDQVLTPAQVNALVGSYRSAGKTFEDTVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z945</accession>
    <name>A0A7K2Z945_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_06230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000281">
        <property type="protein sequence ID" value="MYW28880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="297" mass="30043" checksum="2DF2B9531A420EEA" modified="2021-04-07" version="1">RQARAVATMFLGLTVANIVGVPAATLLGQHLGWRATFLVVAAIGLAAMAALARLVPRIPVEAHQDVRRELRALGNRQVLLGLLTAVFGFAGVFAVYSYLSAMTTEAMGFGESSVTIVLALFGIGMTLGALAAGPLTDRALRPTLYGSLGALAVVLVAFPFTVDVQWAALVMVVLLGGVGFMTTTPLQMLVMNKAKDAPTLASASNHSAFNLANAGGAWLGGVAIAAGWGWTSPAFVGAVLAVLGLAIAATAGFLDRGDGGGSRVVANSARPAFEDKPTTEVAAASSPSGTPSSPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z981</accession>
    <name>A0A7K2Z981_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_06320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000295">
        <property type="protein sequence ID" value="MYW28897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515617.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000295.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="256" mass="27499" checksum="73CDBD1067163CA8" modified="2021-04-07" version="1">MTTTPTVHRATAVAARATELSKVYGEGETQVVALDRVTVDFPQGEFTAIMGPSGSGKSTLMHCVAGLDSFSSGSVRIGDTELSTLKDKQLTQLRRDKIGFIFQAFNLLPTLTALENITLPMDIAGRKPDAAWLQKVIDMVGLSDRLKHRPTELSGGQQQRVAVARALASQPDIIFGDEPTGNLDSRSGAEVLGFLRNSVRELGQTVVMVTHDPVAASYADRVIFLADGAVVDQMMHPTADGVLDRMKAFDAKGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9G3</accession>
    <name>A0A7K2Z9G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000295">
        <property type="protein sequence ID" value="MYW28905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="272" mass="29267" checksum="0C7AC07955295D27" modified="2021-04-07" version="1">MQQLFEGHRLTPTQRRIAHCMVRRAADAPFLSSVELAELAGVSQPSVTRFAVALGFDGYPALRRHLREVAPADAEQEDAGETYNEYQQAVRAEIENLQHLSDLLADPGPVERAGRLLAGSRPLPVLGLRAASSQARGFGYFAAKVHPDVRVLDEGGSMLLDRIDSARRAGATALMCFALPRHPRESVEALAYAGEQGLTVVTVADSAFAPVAKHSDLLLPAAIGSGLSFDTVCAPMLLGRVLLEAMCDELPDAQARLEEFDVRAAARGLFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9H1</accession>
    <name>A0A7K2Z9H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000306">
        <property type="protein sequence ID" value="MYW28996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8573" checksum="02B232706B2D7CDD" modified="2021-04-07" version="1" fragment="single">MGLEFGHNLGLRRALRGLPLSPLVPGYRRLVARQRALGLRHIGDALVERGRVLGVLDGVFEEGGARRRRHIGADRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9L3</accession>
    <name>A0A7K2Z9L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000313">
        <property type="protein sequence ID" value="MYW29024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11037" checksum="ED3F93316EB9A6EA" modified="2021-04-07" version="1">MEDDVPVVTEWTENGLPQRRSRGRAPLGSHNLPQQPPPPAPVNGGLPSRGGHPDGGYGESGGPGGSGGEKPPGLWLEAFTKAVNGVPQEPKHGEDSDDAWDKGDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9U0</accession>
    <name>A0A7K2Z9U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PhzF family phenazine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000341">
        <property type="protein sequence ID" value="MYW29104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="173" mass="19271" checksum="15CD26F04ED01308" modified="2021-04-07" version="1" fragment="single">MNDYDVPRGIDVLRVFCGPDGRHGNALGVVRDGRSHPDDASRQQLTRQLGFSETVFVDDPERGRVDIHTPGLRLPFAGHPLVGAAWLLDLEILELAVGDVFARQDGEFTWITARPEWAPPRMFQQYATADEVEALPGPPPGEGWLYAWAWEDEAAGRVRARAFPRRGEGIVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9X1</accession>
    <name>A0A7K2Z9X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbjN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000355">
        <property type="protein sequence ID" value="MYW29128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="20017" checksum="305A91FE869E8D5B" modified="2021-04-07" version="1">MSIDPSSIPNFGGQPEPQAAGPEGPVVPDQDLVKQLLDQMELKYVVDDEGDLAAPWEEFRTYFMFRGEDEQQVFSVRTFYDRPHALDQRPVLLDAIDDWNRRTLWPKVYTHAHEGEEGEAGSVRLIGEAQMLIGTGVSLEHFVSSTVSWVRASIEFDKWLLERLGLAPAEEKTDGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Y7</accession>
    <name>A0A7K2Z9Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14771" checksum="8C690E8358F722D4" modified="2021-04-07" version="1">MTVTRHPEADRARDNTATVLTAMRELFGEKDLTALDRYWAEPYVQHSPGMPSGLDTLRTVVPDLRGFRWEPQRIAAQGDLVFTHSVVHGWAQGPVAIVDIFRLENGRIVEHWDVVQDLVPPEETVSGEPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA36</accession>
    <name>A0A7K2ZA36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000363">
        <property type="protein sequence ID" value="MYW29204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="12308" checksum="768FC6751085469D" modified="2021-04-07" version="1">MSEKAPNDARLLPWTGLGGRPCYVIGNGTGKVSQAADKVEAQQLSMALELLDHADDMLADEQATEIQLRHISAALTHSLRDVHRVARSRGLRLGIPDDSGEEHPSGHGLVRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA60</accession>
    <name>A0A7K2ZA60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000372">
        <property type="protein sequence ID" value="MYW29247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029554537" evidence="2">
        <location>
            <begin position="35"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="29805" checksum="791345D4B32930C5" modified="2021-04-07" version="1">MMTKHRRNGARLVAVAAAGVLLAGCGSSGGKTGADPDPEPSGSVKQTGESAEPSGTPDPKKPEESKEPGALPGAYEFTPDPARVPRTAAEARRLTRNAALGENDWTAGMVRGTPYETAGTWTVLADSCVWSRSALPDGVLDSFTRRLDVPAQDGKGRVRGSVTVTVHKTVEDADREIKDTVQESFRCPSQELGGGQRLNGLMSLQFDQKDVRNADASLFEAGKYTGPGSGGTQDYVWSKSRIGPVTTAVSVKGAKGYQNSDLLRIAAEGGAKVLYRVELELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAE7</accession>
    <name>A0A7K2ZAE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_08455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000387">
        <property type="protein sequence ID" value="MYW29308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="oligo_HPY" evidence="4">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW29308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="18761" checksum="5A936A551D9D14F4" modified="2021-04-07" version="1">DRYPHELSGGLAQRAATALALIGDAPLLLADEPTTGLDRDLVERTVDELRRHTDEGRALLIITHDLAAAERIADRVAVMYAGRIVEIADAGPFFGAPGPRHPYAKGLLDALPERDFAPIPGMPPELGALPDGCAFAARCARADARCTAERPAFDDGLACHHGLTGRASHSLTKAAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAI1</accession>
    <name>A0A7K2ZAI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="88" mass="10241" checksum="AFE845097F7E6D12" modified="2021-04-07" version="1">MKRRAEFTERAARLRDYLPSDDRRTLKCLVDRVTEDPYGPSTYLAFTNDELTRCSWLDGAMIHFIATTDVIYVVDADIYDVDRGFNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAQ2</accession>
    <name>A0A7K2ZAQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000413">
        <property type="protein sequence ID" value="MYW29430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018488586.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000413.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="65" mass="7282" checksum="129C1BD2BD34C1E1" modified="2021-04-07" version="1">MAGLNLRFTEEELDSLRSRAEAEGKSMQAFAHDAVITAINEHSRLFNEAADHVLKASEELNRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB35</accession>
    <name>A0A7K2ZB35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000447">
        <property type="protein sequence ID" value="MYW29522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="9897" checksum="F90048050CF36A44" modified="2021-04-07" version="1">MNTIICPVVAEGPLPDPVAQLKTARRLVEDRYSSEQPLARAALHLIDCATDIVGQLPDGDLDAARGALGSARAAVVSATFAVGRVRDMSAAGADQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBD6</accession>
    <name>A0A7K2ZBD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000467">
        <property type="protein sequence ID" value="MYW29643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="57" mass="5851" checksum="326390133C8C8BA2" modified="2021-04-07" version="1">AATTGSLSGAVPKLGSPEQAVTELRVRRRRLVRSAIRTAGPDGGPGQSNAYASTSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBH5</accession>
    <name>A0A7K2ZBH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="494" mass="53860" checksum="2EC3DC0AABAF4886" modified="2021-04-07" version="1">MSEDEKNPAREVISDYAQSHFRYFRTADGTVYAQKNGHPVARPIRSQGTTGSHRQELMVGMFKDEVGVFNGTALKEALDLIEALAMTETTQAVHIRVAPGFDGATWLDLGRADGQSVRIRPTGWDISVPDPREVCWRRTQLTGELPLPAKDTDGKGIDLLMRLCNFANAETECLAIAWLIGCLGPGVPVPAPFLTGPQGAGKSTGGRMLVRIVEGMSGDLRRAPKDEENLIAAVAAGWVTALDNLSHMTPDLSDAMCCIVTGAESVKRALFTDGDVHRARYRRPLLLTGIDVGVIRPDLAERLLPLRLERPTVRRTEAELWAEYEEVLPVVLGSLLDLTVKVRAAVAETPTDLRMADFAHLCAQLDTATGLGALPAYRASLDDLNDDVIEGDLLAQTVLQHAETLDPGGEQRMTSTEWLHALSRLYSGEELRPLPKGWPTTGKVLSDRLKRLQPTLAARGVLIDTGRTKAGRYLEMTRQAASPPPEQPEQAAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBI0</accession>
    <name>A0A7K2ZBI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_10350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000475">
        <property type="protein sequence ID" value="MYW29668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047761">
        <property type="term" value="F:butyrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8487" checksum="514F14CA9F3737AA" modified="2021-04-07" version="1" fragment="single">MTTSPIPQHEGTAPVEPHRVLVLNSGSSSVKYQLLDMRDRSRLASGLVERIGEETSRLVHTPLAGGGAEPRERTGPIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBL6</accession>
    <name>A0A7K2ZBL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000493">
        <property type="protein sequence ID" value="MYW29760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="24460" checksum="B3D5B315E3AECC62" modified="2021-04-07" version="1">MTVNHRAEAEKHLGNAARHLTEDPGDMRIAEVAAAIGQGHAALARSEETTSTAADMNEALQSLRRRFNDTRTHVSKHVAEALASRQMDRWKAASDLTKALDEAHCNMDALVDAHLADDGWDPRSAYKVPAGEAGWIGFAAEKNTERDPWAPAPDLTAQIPEPIRRVLAGHLAEMLLDPKPDDVQKWARGITFELKREGLDLGEAIKKRITDLTLGPDPSDPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBS9</accession>
    <name>A0A7K2ZBS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000499">
        <property type="protein sequence ID" value="MYW29793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="10401" checksum="73DF7A1E4D4099FC" modified="2021-04-07" version="1" fragment="single">MDQPTSGAEPADAADGGAEALDRPLPEGVRRRVIALVADAFGGLTVAELPAQLRQYARFTPTRRAKFAGNAMAAALEGDPLFRQRIGERLSQAQPELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBT9</accession>
    <name>A0A7K2ZBT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000500">
        <property type="protein sequence ID" value="MYW29804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515860.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000500.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="11291" checksum="397587C6A57733C5" modified="2021-04-07" version="1">MDGGTPGQRLDAAQLGAELGERATLVQFSTAFCQPCRATRRTLADVAAMVDGVAHIEIDAEAHLTLVRQLDITKTPTVLVLDGAGQVVRRASGQPRTADVVAALGRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC11</accession>
    <name>A0A7K2ZC11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000523">
        <property type="protein sequence ID" value="MYW29887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="368" mass="36353" checksum="46AA28A2A8F8A86D" modified="2021-04-07" version="1" fragment="single">MSSRRAAWPLVAVFTAGYLASYLLPTIVGRLSVHLGLTPAQAGLVGSALLLSSASAGFTLAGRVERYGSRTPARVGLVLAAVGYGSAALAGSVPLVVASVMVGGFGSGTATAVAAAGIAAQRDPHRTSSLGLLTVSATAGALYLTIPHLGGGHRLPFAAIALVALLVWPATTRLNGPTAPEESASRITGRLPHRRSGLVLAGGMLVWSMAQNALWGVSSRIGVVQVGLSEVTVGAVFAAALGAGLLGVMGAGVLGARVGRAVPIGLGTVVIAGSIVVSSSARDLGSFATGEILWNTVYPVVLSYLIGLAASLDVRGRWAVLAGSASSVGVACGPLLGSVLSEEAGYPAMGLILGAATLLVAAPVTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCG4</accession>
    <name>A0A7K2ZCG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000564">
        <property type="protein sequence ID" value="MYW30044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="28426" checksum="C9CC827C73A06F8A" modified="2021-04-07" version="1">MTDIESRIDTTRPHTARIWNYWTGGKDNYPVDREAGDRIRALHPGIGEYAKADRLFLGRAVRHLAGEEGIRQFLDIGTGLPSADNTHEVAQRVAPDARVVYVDNDPLVLAHARALLVGTPEGCTDYLDADLRDIDTILAAASKTLDLSQPVALMLLGVVIFIEDDEESYAVVRRLLDALAPGSHLVLSHTVTHPDMPDVDEAVAFWNEHGTPKLTQRTPAAVARYFDGLELLEPGVVSCSAWRPETPAADVAMYAGVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD42</accession>
    <name>A0A7K2ZD42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000634">
        <property type="protein sequence ID" value="MYW30274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="193" mass="19807" checksum="18DF3489E88B2F9B" modified="2021-04-07" version="1" fragment="single">YQAERRAAVAARLRAADQSLPILRGGGGLRTLVPGTVRGHDTLLADGHLGRGALGAPPSYSHSPLAPPHAEAHTTVGTPPGAPVADVRVTAPDGTAVRLRERLGQGHPLVILVAPGTGVWDRRHWLTAGIMPRLVEAVEALPSPAELLVTESYPGASAHTVLLVRPDGHLVAAFAGVRPAELLAAARAALGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDM0</accession>
    <name>A0A7K2ZDM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alginate_lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000675">
        <property type="protein sequence ID" value="MYW30460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alginate_lyase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="376" mass="40804" checksum="BB9D76262431CC7A" modified="2021-04-07" version="1">ERAPAAAPAPAAAAAPATFTHPGVLVSRPQLDFVRGRVQAGAQPWKGAYDQMMGSRYASLSRTAKPRAIVECGSYSNPNNGCTDEREDAIAAYTLSLAWYITQDSRYAQKAIEIMDAWSAVIRDHTNSNAPLQTGWAGSSWPRAAEIIKYTYSSWPNSGRFGTMLRNVYLPKVTNGSHSNGNWELSMTEAAIGISVFLEDRAAYDKAVSKFRGRVPAYIYVTADGTLPRTAPGSGLDTRAKIINYWQGQSTFMDGLSQETCRDLTHTGYGISAIAHIAETSRIQGQDLYPEVADRLRHAMGLHAKHQLGTPVPSSLCGGSLKDSLGPVTEVGFNALSNRLGYAMTNTRTLTERQRPAGTNNLFVAWETLTHADNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDM4</accession>
    <name>A0A7K2ZDM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="358" mass="35263" checksum="78B84F94B120B79D" modified="2021-04-07" version="1">MDMTENLRPSGAHPTDQDPTSYAYGSTGYSDSAHDGSTAYDGAAGGYPPPPPYAPTNNHRRAKRPVALLAAVALAAAVVGGGTATLVGQLNNGSAQATGSPGTVQGTTVSQSSKGTVSGVAEAVSPAIVEIGAASSAGRSTGSGVVITEDGEIVTNNHVISGAQQIQVTLSTGKTYTADVVGTDPDKDLALIKLRGASGLKTAALGDSSQVKVGDQVVAIGSPEGLTGTVTSGIISALDRDVTVAKDDSGSSGQGQGQGGGSDQWPFEFGGQQFNGDTGEKTTTYKALQTDASLNPGNSGGALINMDGEIIGINSAMYAPSSSAAGSGSSAGSVGLGFAIPVNTLKADLDTLRAGNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDP3</accession>
    <name>A0A7K2ZDP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_14395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000669">
        <property type="protein sequence ID" value="MYW30439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="10">
        <location>
            <begin position="84"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="9">
        <location>
            <begin position="174"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW30439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="355" mass="36958" checksum="0053E2FAD0F07CE8" modified="2021-04-07" version="1">MSTPEENPRPTPVDVPLIRVGAPAPAASSGGCGDDCGCGDGFDPDALECGLDPALALLLAEAGLDPVQVEDVAHVAIEEDLDGGVDVTTVATVPEDAVITGDFTAREAGVVAGLRVAEAVLSIVCTEEFEVERHVEDGERVAPGQKLLTVTTRTRDLLTGERSALNLLCRLSGIATATRAWADVLEGSRAQVRDTRKTTAGLRALEKYAVRCGGGVNHRMSLSDAALVKDNHVIAAGGVAEAFKRVRAEFPDLPIEVEVDTLEQVREVLDAGVDLILLDNFTPAETAEAVALVDGRAILESSGRLTLDSARAYADAGVDYLAVGALTHSSPILDIGLDFRDAGAATDTTRDGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDT5</accession>
    <name>A0A7K2ZDT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylamine--glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000668">
        <property type="protein sequence ID" value="MYW30435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="484" mass="53711" checksum="7C943E4393E63D5E" modified="2021-04-07" version="1">MGAEQIRRWESGALAHAVSDPFGQGPLPWLRGSENYFDDTGQVVPWYADLGRGTGGGTRTADDVRRQIKGFVSPGAAAPGEAIDFHITVDPPQQFSVDIYRIGHYGGDGAAKITTSPRLSGIVQPPPLAADRTVSCHHWWMSWRLQIPTYWSVGAYVAVLTTADGYRSHIPFTVRHDHPADLLLLLPDITWQAYNLYPEDGRTGASLYHAWDERGRLLGEEDAAVTISFDRPYAGAGLPLHVGHAYDFIRWAERYGYDLAYADARDLHAGRVDPSRYRGLVFPGHDEYWSTPMRRAAERARDCGTSLVFLSANTMYWQVGLAPSASGIPDRLLTCRKRRGPGKSALWREVDRPEQQLLGIQYAGRVPEPRPLVVRNAEHWLWDATGAADGDEVPGLVAGEADRYFPRTSLPEHDNRILLAHSPYQDSEGAVRHQETSLYQAPSGALVFASGTFAWSPALDRPGHTDPRIQQATANLLDRICKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDT9</accession>
    <name>A0A7K2ZDT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000713">
        <property type="protein sequence ID" value="MYW30523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="28708" checksum="DEAFF91598BCAE65" modified="2021-04-07" version="1">MRLYAVVAAGGFRRYATYRTATAAGVFTNTVFGFILAYTYTALWDARPQLGGYDMSQALAYVWIGQGLLAACAMMGGGFEDELMERIRTGDIAVDLYRPADLQLWWLAGDLGRAAFQLVGRGVVPMLAGALDFDIALPGSAWIWPAFLLSVLLGVVVSFAVRYLVALTAFWLLDGAGATQMAWLLGLFFSGMLLPLPLFPGLLGEVARMLPWSSLLQIPADVYLGKHTGWGLVEAYAFQGGWAVALLLAGRLLQSVATRRVVVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE47</accession>
    <name>A0A7K2ZE47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000723">
        <property type="protein sequence ID" value="MYW30637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="19820" checksum="5CFCC778C0180ED3" modified="2021-04-07" version="1">MTTPRPTLTLSSTVIEAPDAAELADFYRRLLGWETVQEEPDWVKLLPPGGGSGLGFQTSKPYVPPVWPASLTPAGDQLMMLHLDFEVTDLEAGVAHAVAEGATPAEFQPQHDVRVLFDPVGHPFCLFVRDQVLGETPAISPEWVAEQARDIRTQDPRASEAVTPDRREAAGTAEEPGSGDAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEH8</accession>
    <name>A0A7K2ZEH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_15875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000738">
        <property type="protein sequence ID" value="MYW30718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="58" mass="6340" checksum="77AE62E809F9810E" modified="2021-04-07" version="1" fragment="single">MSQDPHVRLTWVQPEDLVGHELRQAAQDGRDAREIEERWYAAGGSPAPECAGASEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEJ2</accession>
    <name>A0A7K2ZEJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_15810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000734">
        <property type="protein sequence ID" value="MYW30705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="24245" checksum="A2A9211A50F621A9" modified="2021-04-07" version="1">GGEGAHLAAADACRWIGGAVARSHARLSEDIRAGRRADLKSGLHRLTDRTYGKLRARAAELGLEPGEYTTSLRCLLLSADPDCRTRVFFGVGSGGLFRLRDGLWQDLEPVIPEEAASGVSEEGPDGDRLTLDLQITTPLSPYSDGPAPPPAELFRFRASVARPGDTLLLCSNGFAEPMRGEPELPDELAERWGPPGPPGLPAFLADTQLRIKGYADDRTCAAVWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZES7</accession>
    <name>A0A7K2ZES7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZIP family metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_16425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000765">
        <property type="protein sequence ID" value="MYW30818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="240" mass="24492" checksum="ADB96FB0D1C463B2" modified="2021-04-07" version="1">MAVFVALGAFLMTLAGGWVAQRVTDRRHLVLGFAGGLMLGVVGLDLLPEAMEAAGTPVFGVPAALLLFVGGFLVAHVVEGLLAVRQVAHGASGERVPQVGLTAAAAMVGHSLMDGIALGAAFQVSGAMGMAVALAVISHDFADGFNTYTLTSLYGNARRKALLMLFAAALAPVVGAATTLLFTLPEELLGGYLGFFGGALLYLAAAEILPEAHHTHPARSTLLCTIGGVGFIWLVVGIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEX6</accession>
    <name>A0A7K2ZEX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_16645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01153">
        <property type="entry name" value="ACAD_fadE5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034188">
        <property type="entry name" value="FadE5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="286"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="472"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="608" mass="66497" checksum="2778E1671E41F4BF" modified="2021-04-07" version="1">MGHYKSNLRDIEFNLFEVLGRDKLYGTGPFAEMDVDTAKSILDEVVRLAENELADSFADADRNPPVFDPETNTAPVPESFKKSYQSFMDSEYWRLGLPEEIGGTTAPRSLIWGYAELLLGANPAVWMYSSGPAFAGILFEEGTEEQKKVAEIAVEKQWGSTMVLTEPDAGSDVGAGRTKAVQQEDGSWHIEGVKRFITSGEHDMSENILHYVLARPEGAGPGTKGLSLFLVPKYHFDWTTGELGERNGVYATNVEHKMGLKASNTCEMTFGDRHPAKGWLIGDKHDGIRQMFRIIEFARMMVGTKAIATLSTGYLNALEYAKERVQGTDLSQFMDKTAPKVTITHHPDVRRSLMTQKAYAEGMRSLVLYTATVQDAIQEKEAAGEDAKALNGLNDLLLPIVKGYGSEKSYEQLAQSLQTFGGSGYLQEYPVEQYIRDAKIDTLYEGTTAIQGQDFFFRKIVRDQGVALNTLSEEIKKFLAGAQGNEELAPALDSLAKAAVDLEAIVGTMITDLTATGEDVKNIYKVGLNTTRLLMASGDVVVGYLLLKGATVAAEKLPTASAKDVAFYQGKIAAAKFFAANILPGVSAERALAENVDNSLMELDEAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEZ7</accession>
    <name>A0A7K2ZEZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3558 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000804">
        <property type="protein sequence ID" value="MYW30930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029811401" evidence="2">
        <location>
            <begin position="29"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="289" mass="29740" checksum="F526F854691AF639" modified="2021-04-07" version="1">MAYVPGVALLAALAVGCSAGSDGSATDADSKPGGTTVTTAPPGKYRTLPAPCRAVPSSTLKDLLPGVAELSRQQQEKALRGAPTITYDTDRKVGCSWKADAPDSTRNLLIDFERVVSYDPLVSDDDRARSLYVKKENAAELPGSSTPGRAPEKGARTGTGEGEKGQEKETGKAGDGTGSADPSPSASDSAGTSADPSSGTPGTPGGGDEDLRPRVISGLGDAAFLDDLLTRAGSTAQHRTVSVVFRTSNVIVTVRYGEQPALVTKVPDSKELQDKAQALARKLAEVISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF06</accession>
    <name>A0A7K2ZF06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxyurea phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000783">
        <property type="protein sequence ID" value="MYW30898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="193" mass="20681" checksum="9E224F9757F50263" modified="2021-04-07" version="1">GGSRLVGEVADSRRAVTVLGGVLARLAAVPAPEGLRTLGDAVERMLAAAPGVVERLADEGERRLLADCVAAVREVAGEPGDRLLHWDLHYDNILAGRADAGRAGEWVALDPKPLAGDPGFELFPALDNLFDAGEVVWRFDALTEALGMERDRGRARAWTLGRVLQNAVWAVGDGERELAPDHAEIARRLLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF62</accession>
    <name>A0A7K2ZF62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_17055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000805">
        <property type="protein sequence ID" value="MYW30939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561125.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000805.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="377" mass="39288" checksum="98E51F6A62FDC394" modified="2021-04-07" version="1">MATEDAVLEALATVNDPEIHRPITELGMVKSVEIDPDGVVAVTVYLTVSGCPMRDTITRNVTEAVSRVEGVSRVEVTLDVMSDEQRKELASSLRGGTAEREVPFAKPGSLTRVYAVASGKGGVGKSSVTVNLAAAMAADGLKVGVVDADIYGHSVPRMLGADGKPTQVENMIMPPSAHGVKVISIGMFTPGNAPVVWRGPMLHRALQQFLADVYWGDLDVLLLDLPPGTGDIAISVAQLVPNAEILVVTTPQQAAAEVAERAGSIAVQTHQKIVGVVENMSGMPCPHCDEMVDVFGSGGGARVAEGLTRTVGAEVPVLGSIPIDVRLREGGDEGKPVVLSDPDSPAGKALRGIAEKLGGRQRGLSGMSLGITPRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFB1</accession>
    <name>A0A7K2ZFB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000816">
        <property type="protein sequence ID" value="MYW31022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="29" mass="2822" checksum="3D7085889FCBDF93" modified="2021-04-07" version="1" fragment="single">MPRPVLRALTGVLALTAAAAVAPLAAPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFG2</accession>
    <name>A0A7K2ZFG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000846">
        <property type="protein sequence ID" value="MYW31091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="161" mass="17385" checksum="4CD6C5C6D039678B" modified="2021-04-07" version="1">MSPVTEEWNEVLRTHLALGEKGSPVLAAAAFSAEAGFFAVVGRGDEDGRPYFRSMPYDAESVVPDDVEALCTVCEEAVHPRGLHIAGTLWRRESREVISDAVTGSELELALLRDGDRAMWVVRAAQGICTFVLVDGDSGAHVTEARSLALDFDSFLVGQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFU3</accession>
    <name>A0A7K2ZFU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000863">
        <property type="protein sequence ID" value="MYW31196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16390">
        <property type="entry name" value="ParB_N_Srx_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014956">
        <property type="entry name" value="ParBc_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08857">
        <property type="entry name" value="ParBc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="460" mass="48043" checksum="504DFD4A25BD651B" modified="2021-04-07" version="1">ACAGSGPLPRTCAQPGDLIDVTLGELHPTQAVLGFDQVFYKLGRYGGDRDEAAGGFNKRFDDWCETNGQGEAASVRPGARLDDPASFSCSVPLGQETPKSIAPMKTAVIGPGGKLYLTDGHHTLTSFLEGPDGSTRLPVRLRVTDNFSSLSTTAFWQRMTAEKKVWLRDENNKPLAVDQLPDRLGITHFRDDPYRSLVYFTRDIGYEVPDGATEFLEFSWGSWLRGKHDTAAYDLTSPGPYLDLVKSASKSMAALAPDAVVDDGRTAAQLGRIAEWNGGKKETGGEFAKLSRPLTDAKPGKLAEALDYKSRVLSAPACTTRITGVRNGPLTVTSGVTCADRAALRGPVTVRAGAALVLTGSTLQGPLQSDRAAAIHVCGSGVTGPLAISRTTGPVRLGGPGCTANAVTGAVVLTGNTGGVLLAANQVTGPVACSGNLPAPDTTGRANEVHGPRTGQCAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG88</accession>
    <name>A0A7K2ZG88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="362" mass="40143" checksum="7C4BBA36B689C9B1" modified="2021-04-07" version="1">MQRAIAQAGGPDGARLAAYSAVSTSLALHSDRRLSQLVGAALPLGSGIGGTSALLKVDGKPVFVKRVPLTERELLPEHARSTANLFGIPAFCQYGVGGGPGFGAWRELAVHTMTTNWALGGEYQGFPLMYHWRVLPETAALPEELADVERVVAYWGGSPEVRRRIDALQRSTASLVLFLEYIPQTLDEWLTEQIEAGEEATDRACSLVERELEAGTSFMNARGLLHFDAHFQNILVDGRRLCFADYGLAISSRFDLSPSETGFFQLHRTYDRCYTRSWLVNRLITKVYGYERGEREALLRACAEGEEPPDGPQVARAILSRHAPLAAVMTDFYVKVQDEDRETPYPAEALRRALRADRSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGA2</accession>
    <name>A0A7K2ZGA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000910">
        <property type="protein sequence ID" value="MYW31393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029554539" evidence="1">
        <location>
            <begin position="33"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="36783" checksum="C27FF83FFC457C7E" modified="2021-04-07" version="1">MQKAQKQRMTTPPRAGRLMAALATATVLCVTASGCVTVHGELEVLPGATESEAAQALTDFITAYNAADKAYDPALDADRVTGSLGAINQAGLKARQTYSPGGNKAHKPLELTDATYIIPKKAGWPRWFLADTDSNRDEDGGKLDTRWLVVFVRSGPDALWKASYLGVVPPSQVPEFTRDKDGLATPVEPQSGELTVSPADLSIAYTEYLQKGTPDIFAPSTATSQWRETRRTTRRAGFSYQYIDQPLTGGTFGPLGLRTEDGGALVFFSSKHFERQVTAKGLKPEVNADVKALMTGEVTNSLTKERISSQLVHVPARGQSSDSGGRVRMLNRLPGLVAAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGA6</accession>
    <name>A0A7K2ZGA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_19240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000905">
        <property type="protein sequence ID" value="MYW31348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="82"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="28042" checksum="D455160124E78155" modified="2021-04-07" version="1">MPPSHASTADSKPSGASGGVQSLERAFDLLERMADAGGEVGLSELSASSGLPLPTIHRLMRTLVVCGYVRQQPNRRYALGPRLIRLGESASRLLGTWARPYLQRLVEETGETANMALLDGDEIVYVAQVPSKHSMRMFTEVGRRVLPHSTGVGKALLADTPADEVRALLARTGMPAATEKTITTPEGFLDALEQVRRAGYAVDDNEQEIGVRCLAVSVPNSPTSAAISISGPAGRVTESATERIVPILQQVAGELSDALASNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGB0</accession>
    <name>A0A7K2ZGB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetate-CoA oxygenase subunit PaaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">paaJ</name>
        <name evidence="2" type="ORF">GT040_19510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000911">
        <property type="protein sequence ID" value="MYW31401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011883">
        <property type="entry name" value="PA_CoA_Oase4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02159">
        <property type="entry name" value="PA_CoA_Oxy4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17585" checksum="CD2930ECDDA771F0" modified="2021-04-07" version="1">MVTDTPLEAELRTLAGSVPDPELPVLTLAELGVLRGVDVEGPGRVTVRLTPTYTGCPAIEAMSADIERVLHENGVPEVSVVTVLAPAWSTDDISAEGRRKLAEFGIAPPRAHSADGGPVPLTLSVRCPHCGSTDTELLSRFSSTACKALRRCVACREPFDHFKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH33</accession>
    <name>A0A7K2ZH33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000967">
        <property type="protein sequence ID" value="MYW31579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="32" mass="3173" checksum="0A15A0F7FFA03073" modified="2021-04-07" version="1">LAARAGAWAVRVHEVGATADAVRVARAVEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHL1</accession>
    <name>A0A7K2ZHL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001024">
        <property type="protein sequence ID" value="MYW31842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="6450" checksum="D0BDD53AF59AFC0B" modified="2021-04-07" version="1" fragment="single">MAAGESSWVAQETLTGRVSTLPRRRKAVLAAGVVVAAGGLATVAALLLSGGGSVGGGTSRTDAAGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI19</accession>
    <name>A0A7K2ZI19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maleylpyruvate isomerase family mycothiol-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_22495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001062">
        <property type="protein sequence ID" value="MYW31968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="SCP_3" evidence="2">
        <location>
            <begin position="171"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="28130" checksum="AEB0E8E2AC707CB9" modified="2021-04-07" version="1">MPPAKKRPRAYDQLRTRTAVLAQFAHVRDAVAALTPGQLARPTRLGDWTVRDLVAHIAQGLGSVSRDLALPEPPGPKPATTLLEWPPAVAAVVRDPGALAPAAAHPDLLALYAEVEAAFLADVPDSSTGDRLLPTRVGSMRLADFLVTRTVELTVHTDDLNEALGLEIPYDRQALAACVRLLADTLADRAPGGSVEVRVPPFAVVQCIGGPKHTRGTPPNVVETGALTWIRLATGRTEWARALEDAEVSASGERADLAELLPLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIF4</accession>
    <name>A0A7K2ZIF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001071">
        <property type="protein sequence ID" value="MYW32039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="395" mass="43837" checksum="4F62A8C008C2F960" modified="2021-04-07" version="1">MTPVPPPAVELSADQARRIALRAQGFLGAPDRRAGVPGVLRHLGAVQLDTISVLARSHELIPYARLGAVGRRTVEEAYWSGGRSFEYWSHAACILPVEEWPHFAFRRRAYRARPHWHHDLPDGAYDTVIKQLSAEGPLTATELGGAKNGGEWWDWSASKVAVERALMYGEVVCTERRGWKRVYDLAERAIPDAVLHDDLSDTECRRRLVALAGKSLGVGTRSDIADYHRLRGEEFDAVVADSGLVPVAVEGWAKPAWADPEALATEPRGRHRTTLLSPFDSLVWERARTERIFGFTHRLEAYVPKPKRIHGYFAMPLLAGGKLHGRVDPAREGTTLIARQASLAGPKAVVPMAEALVEAAAWVGCTDIRLERIDAPELRDPLRDEVGRALQRAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIR7</accession>
    <name>A0A7K2ZIR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001114">
        <property type="protein sequence ID" value="MYW32227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="168" mass="18852" checksum="15DFC2541F621324" modified="2021-04-07" version="1">MTVIDGTSRSTPTTGAPPRAQPSSGVNACTALPKPHPRPEGKDSYTISEVVAFTGLTAHTLRWYERIGLMPHVDRSHTGQRRFSNRDLDWLVFVGKLRLTGMPVADMVRYAELLREGESTFEERQELLESTRRDVITRIAELHDTLAVLDHKIEFYAGARTAPERHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ28</accession>
    <name>A0A7K2ZJ28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001153">
        <property type="protein sequence ID" value="MYW32363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="283" mass="31120" checksum="8580522CE436C04A" modified="2021-04-07" version="1">MAERPARQGPKAQGAQVVRTEQITPHMVRVVLGGEGLADFSLDGFTDHYIKLCFAPEGADYAHPFDIAAIRESHPRELWPTTRTYTIRSWDPVAREMAVDFVVHGDEGLAGPWAQRAQVGEQVTFLGPGGGYGPQPSAGWHLLAGDESALPAIATSLEQMPAGALVHAFVEVPDASEEQKIVTPDGVAVTWLHRGDRPVGELLTAAVKELDFPEGEVQAFVHGEAAFVKEIRRYLRMERQIPLTQLSISGYWRLGQNDDAWRAVKREWNEQVEREQEGPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJT5</accession>
    <name>A0A7K2ZJT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001196">
        <property type="protein sequence ID" value="MYW32519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510974.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001196.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="13299" checksum="3EBC7113AE50676D" modified="2021-04-07" version="1">MELNPLEQALHTARALVMADLVAGDVAEADVVSLVEDAVTHRRWWVEQWPEGAEFVAGLVAQDVQDALLEKYGRWPLCPACTEDEPHALDVEPELGPDPHWVCTKAAVAVAPVGALGEVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJW5</accession>
    <name>A0A7K2ZJW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001197">
        <property type="protein sequence ID" value="MYW32549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="232" mass="24762" checksum="BE13395A5D5683B4" modified="2021-04-07" version="1">MALQRSVPTAGTAHGAMPAQPGAPGRELFEPRTPVVRDLRGRTGHGPYSLDFTPGDIVVVSGLPGGGKSTLIRRAVSGPAIDSQNTRDRWAAALPRLLPYALYRPLVRAAHYLGLWAVLRSGASVVVHDCGTQAWVRRWLALYAARRGRTLHLLLLDVDPATARQGQWERGRGVSGYAFARHRHAVARLIRDTEQGALPPGCASAVLLDREAASALSRISFSDGEAPAACAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK51</accession>
    <name>A0A7K2ZK51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001247">
        <property type="protein sequence ID" value="MYW32727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8219" checksum="99BA5204CCF5DCAF" modified="2021-04-07" version="1">PHVHGANLGVATAAYRDVGGFPSLATGEDHALVEALERRGHRVLRTAHCPVLTSPRLQARAHGGFGDYLAAMPRPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKG4</accession>
    <name>A0A7K2ZKG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001259">
        <property type="protein sequence ID" value="MYW32837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="531" mass="57489" checksum="78F6DFB485969E56" modified="2021-04-07" version="1">RHDATAGFDPEPLMTARDAAAVTPSQARTRPVALHGPRGVAERMVPAIAALADPDIGAPAEGPGRDRARELLDAAAEVLDAAARSIRRGTPVEVPPRASELLREGTKHEVLEGPARQAAERLRELLGEALEIAECGNARRRTPVRHGGARVELLERPTMFRLVPVVARAVRRELRRDSPVFRHAVRLAAVATLGYLIAAQLPLGHGYWAPIASVMVMRPDFHRTYARAVARLAGTLVGVALATGAVEALGPDARLFGALAVVSAGLSYTLIRTGYAYSQCFTAAYVVFLLGMGGQAWEQTVPERMALTLLGGALAMLAYAVFPAWETPRLRERLADWLAANGRHAAAVLRHFAEPTADRRADMRSAQLASRRARAAWQEAYDQAQQEPVRPRGLTAQEAKAAQEALEGFDRAATLMESRVPHDDHPSTPEVEALAEALESDTEQAAAAMREHRDPDWARVEKALQTWERAGGRSPALRSEADLQKHALENLATAVSRTPLERDVGSLREDQRVREAVEAQGDGSEPAHRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKQ5</accession>
    <name>A0A7K2ZKQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001282">
        <property type="protein sequence ID" value="MYW32908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="34"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="24794" checksum="D6532BE53CC5A679" modified="2021-04-07" version="1" fragment="single">ALGVGAAFALRGVVPTRGQLPAPGRPPGEAPALPGGKGLVVVVNEASGTATATASMVREALPLAEVVECAPADLSTAMEKAAGRGQALGVCGGDGTVNLAASVAATHGMPLAVFPGGTLNHFAYDLGIETVQEAAAALTAGDAIQVDLGRFRPGPNGPEGADGYFLNAFSLGAYPELVRTREHWSPRIGGWPAGVLAALHVLRGQRPLEAELQGRKRPLWLLFVGNGLFQRVGPAPGRRHNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKU3</accession>
    <name>A0A7K2ZKU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan DD-metalloendopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001298">
        <property type="protein sequence ID" value="MYW32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029658157" evidence="2">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="17960" checksum="B8849BE7A198445E" modified="2021-04-07" version="1" fragment="single">MFLLAVALLTAALPVASAGARLLPAARTGEAPPPTEPDAGAEAPPPVAGPDEGADAGEQADSSTGAGGGTFAELDGGPVWPLTGRPAVLRGWEPPATPYGPGHRGVDLAARPGDAVVAAATGRVSFAGRVAGRGVLVIELAGSGAPPLRTTYEPVRALVDKGDEVVAGQPVGVLEAGPFHCAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLF1</accession>
    <name>A0A7K2ZLF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001348">
        <property type="protein sequence ID" value="MYW33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018310">
        <property type="entry name" value="Put_endonuclease_Z1-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10593">
        <property type="entry name" value="Z1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Z1" evidence="2">
        <location>
            <begin position="407"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="910" mass="102575" checksum="1FA18B7570ECC903" modified="2021-04-07" version="1">MFSQDRQPSPEEVDNAVTVISGMLAGQGEVLDRDRLAKEIEQVTAVFQEGSSGLDDGDTTKHEPWLPEAKNDREWEFWERYRRYLEDVRNLPPAVVRRLDQSTDEVLSQLEDPRREGAWRRTGLVIGQVQSGKTGQYIGLASKAVDAGYQLVVILAGIHNDLRSQTQLRVDEGLLGFDSQHQQRSNEAGSRMGAGRMPGAKRLDIASPTNSSERGDFGRSAANAFNSVRLGHFPVVLVVKKHWKILEYLRNWVKEVKGTEDETGRTVIRDIPLFVIDDEADNASVNTKRDPEADPTRTNGAIRELMRTFYKSAYVGYTATPFANIYIDPDVEHPTFGADLFPDSFIRALPSPSNYLGPERVFGLRVDDEDEEDVAPLPLLRSVNDAERWIPSKHKSSFVPSDDLPLSLREAVASFVLACAARKARGQARMHNSMLVHVTRFTAVQRIVHDQVFDYLGFLKDSLRDRHGQASQQTTAEFRTLWERDFVPTTDQFPTGEVEPLSWEEVSEHVQSALRKIVVRTVNGASRDALEYYEHRRNGFWVIAIGGQKLSRGLTLEGLTVSYYLRTSNTYDTLLQMGRWFGYRPGYEDLCRLYTTPALQAKYVEVTAATDELRREIEEMAALDLTPSQFGFKVRASSLGLTITAPNKMRQGTPVRLSYSGEGPETTLFNLSKRVRDNNLKLLEDFVRRMDSTSAPEPEAPGGSVIWTGVPRDAVSEFLSKYVTDSMAARVRPRFIAKYIDKCANVNELSEWTVRLVGKAAAEETQEVANRKIGPVSRAPINDPGYKTDGRYIIRRLVSPKDEQTGLDPDQVSTALENTQKAAEKKKKVAVPRAPSGEHLRHQRRPDQALLLIYLVDLTEREISGQHPPLVGFQVNFPRSEHQAETEYVVNSIWKQEGLDDDFDDEEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLG6</accession>
    <name>A0A7K2ZLG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase maturation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_28910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001349">
        <property type="protein sequence ID" value="MYW33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="PTHR14463"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="484" mass="55259" checksum="78E0DF9106A1F15F" modified="2021-04-07" version="1">MEWFSADGYWLSRLVFQRTLAVIYLVAFLSAALQFRALIGERGILPVPELLRRTPWKAAPGLFRLHYSDRFFAAVAWGGCAVSVALIAGLDGVLPLWGGMLLWALPWVLYLSIVQVGQVWYGFGWESLLLETGFLAVFLGTGDTAPPVLVLWLMRWLLFRLEFGAGLIKMRGDACWRKLTCLDFHHETQPMPGPLSWFFHHLPRTVHRVEVAANHVTQLLVPFLLFTPQPVASAAAALMVLTQLWLVLSGNFAWLNWLTIALALSVVDWTRFVGRPAALAAPPLWYEVVLIAVMGLVLVLSYRPARNLLSRRQVMNRSFDPLHLVNTYGAFGSISRMRLEVVVEGTADPVADESAEWREYGFRGKPGDVRRLPRLFAPYHLRLDWMMWFAALSPAYARSWFGPFTERLLLGDRDTLRLLAHNPFPDTPPAHVRARVFHYRFTEPSELRATGRWWDRTYVREFMRPVSRPLPPEREGRDTGRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLN7</accession>
    <name>A0A7K2ZLN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FO synthase</fullName>
            <ecNumber evidence="9">2.5.1.147</ecNumber>
            <ecNumber evidence="8">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GT040_29355</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the radical SAM superfamily. CofH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="9"/>
    <dbReference type="EC" id="4.3.1.32" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001359">
        <property type="protein sequence ID" value="MYW33261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00293">
        <property type="entry name" value="((2_3_4_5-tetrahydroxypentyl)a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="69"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="528"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MYW33261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="862" mass="94222" checksum="A6902A5786988CF1" modified="2021-04-07" version="1">MTDPDPQSGRPTSNAMRRALKRARDGVALDVTEAAVLLQARGDDLTDLAASAARVRDAGLAAAGRPGVITYSRKVFIPLTRLCRDKCHYCTFVTVPGKLRRAGHGMFLSPDEVLKIARDGAAMGCKEALFTLGDRPEDRWPEAREWLEAEGYDDTLAYVRAMAIRVLEETGLLPHLNPGVMTWTDLQRLKPVAPSMGMMLETTATRLWSEPGGPHHGSPDKEPALRLRVLEDAGRSNVPFTTGILIGIGESYEERADSLFELRKTARAYHGIQEVIVQNFRAKPDTAMRGMPDAELEELAAAIAVARHILGPSARIQAPPNLVDAEYALLIGAGIDDWGGVSPLTPDHVNPERPWPHIDELASRTAESGFQLRERLTIYPEFIQRGEPWLDPRLLPHVRALADPETGLAREDAFPVGLPWQEPDEGFTSSGRTDLHTTIDTQGRTGDRRNDFDEVYGDWEALREAAAPGMVPSRIDADVRQALSQAADDPTKLTDDQALALLHADGPALDELCRIADALRRDVVGDEVTYIVTRNINFTNVCYTGCRFCAFAQRRTDADAYTLSLDQVADRAAQAWDVGAVEVCMQGGIHPDLPGTAYFDIARAVKERVPGMHVHAFSPMEVVNGATRTGMSIRDWLTAAKEAGLDSIPGTAAEILDDEVRWVLTKGKLPTATWLEVIKTAHEVGLRSSSTMMYGHVDQPRHWLGHFRTLSRLQQETGGLTEFVTLPFIHTNAPVYLAGIARPGPTDRDNRAVTAMARLLLHPHITNIQTSWVKLGTEGAAEMLRSGANDLGGTLMEETISRMAGSSYGSYRSIQGLQEIADLAGRPSRPRTTLYGEVPAERIAAATASDGHLPELLPVVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMI3</accession>
    <name>A0A7K2ZMI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_30910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001434">
        <property type="protein sequence ID" value="MYW33557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="17417" checksum="BCB5F4CEF553ED41" modified="2021-04-07" version="1">MPKGTGETRRYLAVGLDCYLCLLVVGLLVHSCLGPAGAGRTAAVLIGHLTVLSFANQVLLTMAVRASAGKLIMGVRVIRLPDAGRPEFRRLVLRWLYGLFWLPLQPWHHLRRGATAEPPPRERLGGGPPTAPHTDLAGVRQVHRSDLRYYREAVEGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMI5</accession>
    <name>A0A7K2ZMI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ORF">GT040_31000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001435">
        <property type="protein sequence ID" value="MYW33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="34265" checksum="BE6255A005D0E63A" modified="2021-04-07" version="1">MSDVRNVIIIGSGPAGYTAALYTARASLNPLVFEGAVTAGGALMNTTDVENFPGFQDGIMGPELMDNMRAQAERFGAELVPDDVVAVDLTGDIKTVTDTAGTVHRAKAVIVTTGSQHRKLGLPNEDALSGRGVSWCATCDGFFFKDHDIAVVGGGDTAMEEATFLSRFAKSVTIVHRRDTLRASKAMQDRAFADPKIKFAWDSEVAEVKGEQKLSGLTLRNTKTGQLSELPVTGLFIAVGHDPRTELFKGQLELDDEGYLKVEAPSTRTNLTGVFGAGDVVDHTYRQAITAAGTGCSAALDAERFLAALADVEPAEPEKTPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN79</accession>
    <name>A0A7K2ZN79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PBS lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001471">
        <property type="protein sequence ID" value="MYW33792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="193" mass="20188" checksum="DA8A5530498A6687" modified="2021-04-07" version="1" fragment="single">GLRLAALAQLARCCPDALPRDVVPVVSGLLRELRTAPGGAPDADPGTDAEVEPEPETDPVGCADLSRAEPGAAPTLVGQLRALSAQDSTGRGAPWAADLLRTLHVGLDDRVGDRTALLVDQLRSPDRWQRIDAVRMSGGLIRAWRGSYGELVALVGDQLADPEPRLAEAASHVLEELFSLAAPTADALAARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNE8</accession>
    <name>A0A7K2ZNE8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rsmH</name>
        <name evidence="8" type="ORF">GT040_32110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001469">
        <property type="protein sequence ID" value="MYW33789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="35032" checksum="715CC814D8034816" modified="2021-04-07" version="1">MSQTRHVPVMLQRCLDLLAPALQDPAHPEPVVVDCTLGLGGHSEALLEAFPTARLIALDRDKEALRLSGERLARFGDRATLVHAVYDELPDVLARLGVPEVQGILFDLGVSSMQLDEADRGFAYAQDAPLDMRMDQSTGIGAAEVLNTYPPGELVRILRAYGEEKQAKRIVSAVVREREKEPFSNSARLVELIRDSLPQAAKRTGGNPAKRTFQALRIEVNGELSVLEQAIPAAVASLAVGGRIAVLSYHSLEDRLVKQVFAAGAANTAPPGLPVVPERYQPRLKLLTRGAELPTEDEIAENRRAAPARLRGAQRIREDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNM0</accession>
    <name>A0A7K2ZNM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001499">
        <property type="protein sequence ID" value="MYW33932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="193" mass="20560" checksum="D2F269187A927FF1" modified="2021-04-07" version="1">MTINLSKGQQVSLTKSGGGELGVVRMGLGWKSAPRKGFLARLTARDIDLDASAVLFAGKDPQDVVFFQHLTSDDGSVQHTGDNRVGGAGEGGDDESIVVDLRRVPVHVDQIIFTVNSFTGQTFEEVEAAFCRLVDETTGQELARYTLTGGGRHTAQIMAKVQRAGSGWQMTAIGAAADGRTFQDLMPAVAQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNS2</accession>
    <name>A0A7K2ZNS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_33215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001516">
        <property type="protein sequence ID" value="MYW34003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="200"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="337" mass="36950" checksum="51635206867C1BB1" modified="2021-04-07" version="1" fragment="single">MSRDIFIVSNSTDELGGVTAWTHQTARLFTEQGHRVHVIGIHASDRKMALPAEPGYPVTALYPAHPPTPWTPHGVRDRFRIPTRRREAARAERKRRAVAGLSELFATARPGAVVVVTQVWAMEWVGEADTTGLRVIGMSHESYDYSRASHRYRWIRNHYKDVDHWLVLTEEDADRWAGDGFDNVGFLPNALARLPHVPSPRTARTVAAIGRLTDQKGIDLLLDTWALVAPQRPDWRLRLYGTGEDEAALKAQCTGLGLDGSVEWMSRTDDVESALAGASVFVQSSRGEGFPLALLEAMASGVPCAAFDCAPGVREIVRDGEDGLLAPAGDTAALADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNV5</accession>
    <name>A0A7K2ZNV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Albusnodin family lasso peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001538">
        <property type="protein sequence ID" value="MYW34036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="44" mass="4776" checksum="BBC81AAEFB13DE53" modified="2021-04-07" version="1">MSTSQNSENTNEHELLPVEIGDATVLTEGQGGGHSEDKRRAYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP00</accession>
    <name>A0A7K2ZP00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ORF">GT040_33605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001541">
        <property type="protein sequence ID" value="MYW34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="26203" checksum="549E67D6AEE21837" modified="2021-04-07" version="1">MSNNGLRLVWVYPDLLSTYGDQGNALVVERRARQRGLDVQRVDVRSDQPVPTSGDIYLIGGGEDRPQRLAAERLRRDGGLSRAASNGAIIFSVCAGYQILGHEFINDLGEREQGLGLLDVVSTRGEGARCVGDVLADIDPRLGLEALTGFENHQGVTHLGPTARPFARVRFGRGNGTGDGTEGAYNDTVFGTYMHGPVMARNPQIADHLLKLALDVNALPPTDDRWYEALRAERIASATQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP20</accession>
    <name>A0A7K2ZP20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001521">
        <property type="protein sequence ID" value="MYW34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6926" checksum="EBB7200F7DE05D33" modified="2021-04-07" version="1" fragment="single">MRNLLPLISSHPGGRSALTCRFRCGDACFQEIPNTSDNEYAGDIIARAVSRRSMMRAAAVVTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP44</accession>
    <name>A0A7K2ZP44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001545">
        <property type="protein sequence ID" value="MYW34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="600" mass="63142" checksum="65BF764BF3FBA4FB" modified="2021-04-07" version="1">MSALGATLTWAKLREVKCAELEEAADGWGRAGNRADAARDRIDTQLVDDLRRTQKGEAARAAVRRLRRLSMNFQYIYTECGLLRTTLNSLAHEMKAQQRVLQGALDDAAALKFTVHPDGSVTYPAAGKGLVDGKPLAGGRASGVPNPGLAGPSGLLAPNPNAAKAQDIADRVAQAVRAAADADWRYARILRALKAEDGLSVPTATWTDAAGDAAAVRQAAHGYLAQGIPHDASPAERKAWWAGLSDEQREEYLAVYPDQIGNLDGIPALVRDAANRDNLQLLMGKLAGRDDEDAVTKLAALREIDRQLWAVREPGEPPMYLLGIGDQGNGRAIVSYGNPDTSRNVAAYVPGLNTSLDEEFARGDLKRARDTAAAAREIDRSTAAIVWLGYDAPQSPDGLNSLAVAGTERAETGAHAFRGFMSGLEASNDHGDPHMTAIGHSYGSRMVGAATQQGGGIPGVDDIVLVGSPGLGVDRAEDLGVGKDHVFVGAADNDVVTRLPSKEQGLLAAAGRALGPAGSLAVDVVHPGDDDLWFGKDPASEDFGARRFAVDPGPPLIGLGRVTLDAHSQYFNPKLDSASADSIAMVVAGRGHQVKQEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPD2</accession>
    <name>A0A7K2ZPD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase SLT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_33915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001548">
        <property type="protein sequence ID" value="MYW34138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029629508" evidence="2">
        <location>
            <begin position="29"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="162"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="237" mass="24849" checksum="267280472C9FFD7F" modified="2021-04-07" version="1">MPRTIRITRSHKLATAVLVAAGSVTAIAATGGQSDAQPAAARTSIAAEKVAGVSTAKEAAAKKAAQETAAKKAAADAAAAKKAVAERKAAAEKAVADRKAEAKKSAEKARSEKQAANRSTERKAVAAPKQYKNNLDGWIRESLDIMKKKNIPGSYEGLHRNIMRESSGNPNAVNDWDVNAQNGIPSKGLLQVIQPTFDAYHVKGTPKKLTDPVANITAAANYAADKYGTIDNVDSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPI7</accession>
    <name>A0A7K2ZPI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_34680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001588">
        <property type="protein sequence ID" value="MYW34284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="152"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="436" mass="47065" checksum="9D55475D084CBC12" modified="2021-04-07" version="1">MSLTSILLTVLGIAVFVVGLLFSIAWHELGHLSTAKMFGIRVPQYMVGFGPTIWSKQKGDTEYGIKAIPAGGYIRMIGMFPPGADGRLEARSTSPWRGMIEDARSAAYEELEPGDEKRLFYTRRPWKRVIVMFAGPFMNLILAVAIFMGVAMTFGFQTQTTEVAGVQQCVISQSEKRDTCKGTDPVSPAKAAGLQEGDKIVAFGGQKVDDWATLSDRIRNTIGPATITVERGGQEVTLNAVLRENAVAKKDGRGEVIPDQFIKAGYLGFAAQTEIVPLGFGDSVVRMGDMIENGVNAIIALPGKIPDLWNAAFSDGQRADDSPVGVVGAARIGGEVMNLDIPAQNQVAMMLFLLAGFNLSLFLFNMLPLLPLDGGHIAGALWESLRRNVAKVFRRPDPGPFDVAKLMPVAYVVAGLFICFTLLVLVADIVNPVKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPP0</accession>
    <name>A0A7K2ZPP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF839 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001596">
        <property type="protein sequence ID" value="MYW34341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="470" mass="49974" checksum="C86378CF1B3DD024" modified="2021-04-07" version="1">MSSETRNTATAATATTAPRNTATRRQVLAGSGAAAAIAFTGAFSELFAGTAAARGHSGYGPLVPDPDGLLDLPKGFRYRVLSREGDPLRSGEGKVPSNHDGMTALAGRNGRVHLVRNHENRHTAKIGVPTVAGLTYDPAAKGGCTSLELDGRNKVLGERVAIAGTAVNCAGGPTPWRTWLTCEETEDKAGTNGYTKDHGFIFEVDGADPRRTGAVPLTAMGRFQHEAIAVDPKNGIVYETEDAFDKPFGLFYRFLPQKPLGGTGSLRAGGALEAMRVPGLPDLSVVQETGASFDRVEWVPVPDPLAAETPIRLQDFGPKGITHAQKLEGCYWGGSSVYFVSSFAHRDEGSAADHYGQVWRYEPKKRRLTLVVVFGPDTDIQLPGESPDNICLAADGGLMVCEDGGGAQHVLGVTRRGEVYTMARGRQNIGTPEEPEWGEFAGVTFSPDGSTMYVNCYTPGTTFAVTGPWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPQ6</accession>
    <name>A0A7K2ZPQ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="3">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuB</name>
        <name evidence="5" type="ORF">GT040_35000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001597">
        <property type="protein sequence ID" value="MYW34346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01035">
        <property type="entry name" value="LeuB_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023698">
        <property type="entry name" value="LeuB_actb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="6"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="347" mass="36938" checksum="0258B628788A8D3F" modified="2021-04-07" version="1">MSRSIDLAVIPGDGIGQEVVAQGLKVLNAVLPQDVKLETKEYDLGAQRWHRTGDTLPDAELEALKNHDAILLGAIGDPSVPSGVLERGLLLKLRFAFDHFINLRPSKLFPNTATPLAGRPDIDFVVVREGTEGPYTGNGGSLRTGTPAEVATEVSVNTAYGVERVVRDAFERAAARPRKKLTLVHKNNVLVYAGHLWKNTFDKVAAEYPQVSTDYLHVDAATIFFVTQPERFDVIVTDNLFGDILTDLAAAVTGGIGLAASGNINPTGAFPSMFEPVHGSAPDIAGQGKADPTATVLSVALLLRHLGYEAEAVRIEDAVSADLAERDGAATRTTDEIGDALAVRVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPV1</accession>
    <name>A0A7K2ZPV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001612">
        <property type="protein sequence ID" value="MYW34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="23764" checksum="BA9E7AE4039365CA" modified="2021-04-07" version="1">MSDTTARSATHLTRRLVQLYVGLTLYGASSALLVRAELGLEPWGVLHQGLTELTGISIGVVSIIVGAIVLLLWIPLRQRPGLGTVSNVFVVGLAMDGTLALVGDLDGYGVRIPVLVLGIVLNGVATGLYIAARFGPGPRDGLMTGLNRVTGRSIRLMRTAIEVAVVVTGFLLGGSLGAGTVLYALAIGPLAQLFLRVFELPAPAPVTVTPAPPAGPDPVATPPSGQAILPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ62</accession>
    <name>A0A7K2ZQ62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbpA</name>
        <name evidence="4" type="ORF">GT040_35760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001628">
        <property type="protein sequence ID" value="MYW34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073217477.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001628.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="12105" checksum="10CC5FE8C2A35A11" modified="2021-04-07" version="1">MASGNAIRGSRVGAGPMGEAERGESAPRLRISFWCSNGHETQPSFAHDAQVPDTWDCPRCGFPAGQDKDSPPDPPRTEPYKTHLAYVRERRSDEDGEAILAEALAKLRGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ78</accession>
    <name>A0A7K2ZQ78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PBSX family phage terminase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_35735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001627">
        <property type="protein sequence ID" value="MYW34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006437">
        <property type="entry name" value="Phage_terminase_lsu"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01547">
        <property type="entry name" value="phage_term_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="411" mass="45325" checksum="3BF1A0A5BDC6C375" modified="2021-04-07" version="1">MSRKQLRSIAQSARHRIAIWSGAIRSGKTIASLVAFLIALSVAPSTGLVIIAGRSLQTIERNLIEPLQDPAIFGALSLQVVHTRGSTTAVILGRTVHLIGASDARAEGRLRGASVCLAVADEITLLPEAFFKQLLGRLSVPNARLLGTTNPDSSAHWLKRDFIDRALELGIGHWHFTLDDNPSLTLEYTESIKAEYGEGTLFFKRFIEGKWIAAEGAVFDMWDDERHVVDALPRMHRWLSVGVDYGTSNPFHATLLGLGTDRRLYVASEWRYDGRHQRRQLTDAEYSERMRGWLGDVPGIGPVRPQFVTVDPSAASFSAQLRRDKLTPTPAKNDVLDGIRTMASLLASGRLLVHSSCKGLIGEMPGYAWDDKAAEKGEDRPIKVADHGIDSARYALFTTRALWQRQLALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQD3</accession>
    <name>A0A7K2ZQD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001642">
        <property type="protein sequence ID" value="MYW34581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="17891" checksum="289663CC258AE184" modified="2021-04-07" version="1">MRDLLRNTDVTRLSDRDIPLMFREVVERGWSVTASGGRVLTALRTEVPGIHSDRLAEETTVNGRGMPDYDLPAAPDERTPLLVRRCLAYVGACLRRAREEFGDTDVKAYVSLSFADTDEALLTSNVTFCTPLPDVRRYIPGLENVADAAVAEISAEDCSAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQQ9</accession>
    <name>A0A7K2ZQQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001658">
        <property type="protein sequence ID" value="MYW34628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_19_cat" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7153" checksum="7D95F1E0C77CAD25" modified="2021-04-07" version="1">WNTQNGPGTMTPHNAIVNNRGFGETIRSINGSIECNGGNPAQVQSRINKFTQFTQILGTTTGSNLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR70</accession>
    <name>A0A7K2ZR70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001695">
        <property type="protein sequence ID" value="MYW34823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7028" checksum="BA6E02AA2E77F50D" modified="2021-04-07" version="1">MTLAAETVADIGTGASTTAHAIHHIRPRLERLGALTTAAARALPNGALVHFSAPRAPRSLPGPIIITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRG5</accession>
    <name>A0A7K2ZRG5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RepL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001697">
        <property type="protein sequence ID" value="MYW34839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008813">
        <property type="entry name" value="Plasmid_replication_RepL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05732">
        <property type="entry name" value="RepL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RepL" evidence="2">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="22707" checksum="E94DF78E04A03477" modified="2021-04-07" version="1">MTSPLADSFAQALDRKPPKPGRPVRAANVEYTYRAPHDAWGRSGYSMVSNAFLADVLAVLIARYGMSPVQSAVLLFCMGRQVEGRLKITHIKVARHLGVERANVTRALGSLENWHMLQRRANSLIVVNPLICFKGNGDLQQEALEQLRQDARAALRKHFPEMREDVVALEKAASESFPEFTAPAAPAPRTRQLAFGDNDVEEQAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRX1</accession>
    <name>A0A7K2ZRX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001760">
        <property type="protein sequence ID" value="MYW35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="188" mass="19238" checksum="7F131C89CB07C570" modified="2021-04-07" version="1" fragment="single">DAPPGAVVVLTVTAARTVAHYGHRAWPLLLLDAGHAAAALALTAAPGDVRVSLDADGEELAAAAGLPRAAERRTRWTGVEPELPLAAIWLRSADALAPSTAPLTAWAALPCAADPLPQPGAGDNAPTCELASARSLLTYLAAGTDPTWRPAARPAPVTDETLRTRRSAALSDLAHPPAPDLLARVLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRX6</accession>
    <name>A0A7K2ZRX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001777">
        <property type="protein sequence ID" value="MYW35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029532801" evidence="1">
        <location>
            <begin position="47"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="80"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="34101" checksum="C6EEC592FA64F923" modified="2021-04-07" version="1">MLFRNRNSSEHRRRRSPRSWRYRVAGLAAAALAVSLIQANVGNAAADRAAAEVAPKAAADVVRVAEFLAECPYTHRAPDDPIVFPGLPGASHMHSFFGNDTTNGNSDLASLEKGRTTCSPDTDLSSYWVPTLYDGDREVEPTGTTFYYLGEGVRDDVIRQIQPFPKGLRIVAGNAKATGPQDNTIARWSCLHAGHVNPSQDFVNCPAGTMLESYLDFPQCWNGKDLDSADHKSHMSYPVAGACPSTHPVPVPKLRQVLRYPVSGDPARFRLASGPGYTMHGDFFNVWPEEELAQRVRDCINAIVKCGFDGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSB4</accession>
    <name>A0A7K2ZSB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_39875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029455409" evidence="4">
        <location>
            <begin position="37"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="54"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW35270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="21601" checksum="942CB15B87533E8E" modified="2021-04-07" version="1">MSFGRPSRRRFTLFAATAVAGALTLTACGDGNTAQGGGNTNFITGKGGISRVAKEERPDAPKLQGESLDGKPLDLADYKGKVVVLNVWGSWCGPCRLEAKYFAKVSEETADQGVQFIGINTRDAQKDPAINFEKDYGVTYPSFFDPIGKLILRFPKGTVNPKAIPSTVVVDREGKIAARTLQPLDAEQLHEMIDPIIAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSP1</accession>
    <name>A0A7K2ZSP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3566 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001834">
        <property type="protein sequence ID" value="MYW35317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="2">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="133" mass="13980" checksum="6E9642E45FCB773F" modified="2021-04-07" version="1">KPRTGARTTPRTRKARLRVAKADPWSVMKVSFLLSIALGICTVVAAAVLWMVMDAMGVFSTVGGTISEATGSNESNGFDLQSFLSLPRVLIFTSVIAVIDVVLATALATLGAFIYNLSAGFVGGVELTLAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5W1</accession>
    <name>A0A7K2Z5W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000003">
        <property type="protein sequence ID" value="MYW27727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="34289" checksum="7C2EA6E19CB675BD" modified="2021-04-07" version="1">MSRFQVVSGKGGTGKTTVAAALALALATEGRRTLLVEVEGRQGIAQLFGADALPYEERKIAVAPGGGEVHALAIDAEQALLDYLQMFYKLGGAGRALKKLGAIDFATTIAPGVRDVLLTGKACEAVRRKDKQGRFVYDYVIMDAPPTGRITRFLNVNDEVAGLARIGPIHNQAQAVMRVLKSPQTAVHLVTLLEEMPVQETADGIAELRAADLPVGRVIVNMVRPHLVDEETLRTGATGRRKEIAKALTRAGVTGSAALVRPLIEQAAEHAQRVGLEREQRAVLAGLGLPTAELPLVGDGVDLAALHDLATELRKQGVGEGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6K9</accession>
    <name>A0A7K2Z6K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_01300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000058">
        <property type="protein sequence ID" value="MYW27943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="428" mass="44626" checksum="54B198C6B712951B" modified="2021-04-07" version="1">MDNEVSMTPPAPTPSRALATEAVHAGRDDLASLGLHAPPLDLSTTYPSYDSRGEAERIDAFATTGARPDGPPVYARLDNPTTARFETALARLEGTDSAVAFASGMAALTAVLLARASLGLRHVVAVRPLYGCSDHLLGAGLLGTEVTWTDPAGIADAIRPDTGLVMVETPANPTLAEIDIRAVAHSCGSVPLLVDNTFATPVLQRPVEHGARIVLHSATKYLGGHGDVMGGVVACDEEFAATLRQVRFATGGVLHPLAGYLLLRGLSTLPVRVRAASASAAELSRRLTADPRIARVHYPEIGGAMVSFEVYGDPHAVIAGVRLITPAVSLGSVDSLIQHPASISHRIVDEGDRQASGVGDRLLRMSVGLEDVEDLWADLCQALSDGPAPRARTAERAARPSAEPPSVRPSHPAAAPHASVPSHSSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6S2</accession>
    <name>A0A7K2Z6S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000079">
        <property type="protein sequence ID" value="MYW28044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029904721" evidence="1">
        <location>
            <begin position="33"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="194"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="387" mass="40641" checksum="BE04D914A6928982" modified="2021-04-07" version="1">MSGRLTVPARRGLLYAAAAGVTTALTTPDARAATHPVSGRAPSTTPWTTSWATAQTAPTAADPLAAAGLTDGLCTARLRLSAGGQVRLRYAHAFGTAPVLVGPVAADGRPVTFGGRTQAWLAAGASLTSDTVEGLRVKDGSLMTVETRLPGPTGPLSFHRNTHAWHTVDGIRTRSVLLLTGVETTGARGPVLAVLGDSIAEGSGTPDDADLRWPDQLARRLPGSAVANLGISGNRLLLDSDQYGPGGQARFDRDVLSLPGLRTVLVHLGVNDLFHVPAERDPSRMVAAYRQLALRARSAGLRVVGATIAPFEGWPRWTPEQDAVRRQVNEAVRTGRIFDAVVDVDAALRDPDRPSRLLPAYDSGDGLHPGPAGHTAIAAAVERRQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6V8</accession>
    <name>A0A7K2Z6V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000091">
        <property type="protein sequence ID" value="MYW28075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="14295" checksum="17CD5693060C87BB" modified="2021-04-07" version="1">MLTLPAMGSAVRIARETTEQVLAEWGVGPQEPCTGPVLLILSELVANSVRHAAVLSPKVTVIFAGGPDAFAFGVHDRHPYRPALYSPAVAGSGRGLATVMELTLELGGSAVVRGDADEGGKSIWVTLPLRRSGAPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z729</accession>
    <name>A0A7K2Z729_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000107">
        <property type="protein sequence ID" value="MYW28156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="6031" checksum="CFC875BE86906C14" modified="2021-04-07" version="1">DGPEGVLVLARPGFVCTVNTTGAPVRIAARGRVLLASSPVTVDGAEAVLPADTTVWWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7B5</accession>
    <name>A0A7K2Z7B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000114">
        <property type="protein sequence ID" value="MYW28203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514433.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000114.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="31835" checksum="C79AC6531D7CC396" modified="2021-04-07" version="1">MTAGKTKLPIAVAIPTKNEGLNIAEAVKSVLGHFEAVVVVDSHSTDDTVKIAEECGAEVVTYTWDGGHPRKKQWCLENVRTDLDWILLLDGDERLSPGLLAELREIFRDPAAPKPAAYDIPLGYWFSGKRLRHGYTIRKRSLTDRTRSYYPEVGDLDAPGIGEVEGHYQPVAATAGTLKNPIEHQDLDPVTAWFERHNRYSDWEAWLEHHPQVKEQVRQVKSRQGQLFHKAPFKPVVSFAYMYLYRRGFLDGRAGFDFALAMSFYRWQIALKSREKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7C1</accession>
    <name>A0A7K2Z7C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000127">
        <property type="protein sequence ID" value="MYW28250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="537" mass="56762" checksum="14C304EB01B6DDED" modified="2021-04-07" version="1">GWLRSTGAPHDRELALRIDDLSAATGEFGTAEPGRRAALLAALRDRWVTFLADLGHPVGPGPARLTVLSEDVVMRQPIRLDGFLGAADHRALGELASLSEVFDLGPAVRRQVRDSFVARYGPGGVCPHVWDFGADADEAWQRASRAADGGAPGTPGGGSIAADGIRRLAALRAELTKAVHRAHADGGGGPDDDVVLPAGLVAGLGSRMPSWATRRPVSYTGFVQRAGGGVLCVNHVYGGWGRFSSRFLDSLDPGAARVAATAVSGTLGPGATVAQVRPVSGFNANLHPRFVPEEIGPDRSYASLGMNDIELVHDLRGDEVRVRVKATGAWADVLYAGVFAPLLLQPRLAPLLMDHPHGITDFGALVPRHLTAVPGGDLVRTPRLRHRHLVLRRRRWGLAGPTVAVLLAELAAEGEVPVGTVARWRALLGVPDQLYLHAAPPARGGRADEDLLSALDRPRPQYVDLGDALHLRCLGRWLARHPGGVVLEEALPAPARGEAHAAVELLVETYRAGLGVGDAADVGARAAAGWANRRDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7E8</accession>
    <name>A0A7K2Z7E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000122">
        <property type="protein sequence ID" value="MYW28235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="21369" checksum="E1642BDF25C12EC4" modified="2021-04-07" version="1">GRRDDRRVALTFDDGPDPVFTRQVVEILGRYGARATFFCVGHHVAALPDEVRRIAAAGHEVGNHSWSHPFLPDLTPEQLREQLDRTGEELARVTGAAPVWFRPPYGALTPEVLAALDGYPTTLTMWDVDARDWSRPGPEQIAATVLEGAGPGSVVLMHEGAGDRAQTVQALPSIIEGLLERGLELVPVGELAAKPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7X3</accession>
    <name>A0A7K2Z7X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000159">
        <property type="protein sequence ID" value="MYW28422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="15"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="164"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="283" mass="28419" checksum="5D4FE10296BE4063" modified="2021-04-07" version="1" fragment="single">MSLPAVSALPVGRSLLYLVIAGVAWGTAGAAASLIFRVSDLGPLALSFWRCAGGLVLLAGALAVRPRRAPRQPEPRRRRLLRILGTGVGLTVFQSAYFAAVDATGLAVGTVVTLGAGPVLIAVGARLMLGERLGKGGLAAVTGALAGLAVLVLGGEGGDVVPAGVLLALLSASGYAAITLLTRWLGRDGGGGDALTTSAWAFGIGAVGLLPMAVVEGLVPHTAETGQVLWLLVYVAAVPTALAYALYFAGAAAVRSATVSVIMLLEPVSAALIAVTVLRERLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z847</accession>
    <name>A0A7K2Z847_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000196">
        <property type="protein sequence ID" value="MYW28511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="123"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="347" mass="38129" checksum="1E32877B73F0E3DF" modified="2021-04-07" version="1">AEAARSVGLPEAQAPADDDRLIEATASYRLDSDQLRKAATVATRLAVLEQRPVHPDDLRTAVRAQNGAGLERLARRIEPAVGWDDLVLPPATRTQLTELALRARHREQVLGQWGMRPGGGRGRGVIALFAGESGTGKTMSAEVVARELGMELYVVDLSTVVDKYIGETEKNLERIFVEASDVNGILLFDEADAIFGKRSQVKDAHDKHANVESAYLLQRMESFDGIAVLTTNLRANLDEAFTRRLDVIAEFPIPDAEQRLALWDRCLGTSIPRDPALDLEFCAARFELAGGSIRACAVTAAYLAAESRAPLTMDQLVTAVLQEYRKLGRLVLESEFGPWLAKERRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z860</accession>
    <name>A0A7K2Z860_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000200">
        <property type="protein sequence ID" value="MYW28549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="139" mass="15572" checksum="36E1E9EA28B11C8E" modified="2021-04-07" version="1">MLAEQLLRLTRRLHRIQSRQLEPIGITPAQFRLLRTVASYDAAPRMADLAQRLDVVPRAVTTLVDALEASGRVRRAPDPDSRRVVRIEITDEGRATLRSLRNARRAAAEEILAPLTAGQREMLGELLSALVDGMPERRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8C3</accession>
    <name>A0A7K2Z8C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000204">
        <property type="protein sequence ID" value="MYW28573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="13573" checksum="59E5DE5AE31BC606" modified="2021-04-07" version="1">MHSTRTVGLSDARRIIDAGIAEGDPIGSPSNIAVADAGGSLVAHVRMDGAQLGSIEHSIDKAHTSVLFRSATGDLARDSEPGGQFWGMALSGLGRVLVFAGGVPLRVDGEVVGAVGVSGGSQEQDTAVARAAAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8D9</accession>
    <name>A0A7K2Z8D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000213">
        <property type="protein sequence ID" value="MYW28619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="10023" checksum="F8B6161CE37CE678" modified="2021-04-07" version="1" fragment="single">MSREPRTQNVTTDAGEARITWVPATTAPRLVLAVSHGAGGGIEARDLKALAAALPAHGVTVALVEQPWRVAGKKVAPAPKTLDTGWRGLWPALAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8V8</accession>
    <name>A0A7K2Z8V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="190" mass="21048" checksum="164A2BD16BEBD7C6" modified="2021-04-07" version="1">MRTLISTAFVSLDGVMEAPGGEPGYRNSGWTFKDMEFLPEAYEIKGREQEEAGALMMGRASYEAFSPVWPAMEEFGQYKVMPKYVVSTTLKEDDLVSDWGDTTILRSLDEIAALKETEGGPVIVHGSTGLNHSLSDAGLIDRYHLLVFPLLLGAGKRLFGASDKDTRKLKLVEYEAYANGIQKNVFDVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z916</accession>
    <name>A0A7K2Z916_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000261">
        <property type="protein sequence ID" value="MYW28839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="139" mass="14871" checksum="3D644DECBB3DF47E" modified="2021-04-07" version="1">TLPVTVPALVVGVLRRRKDPEASSWTAYGPGLAATLLPSLAVAWTDPDWVRPLLLGVAALVITLLGAKYRLQALLLLGGAVLALDTLHELAPYVVQVAGALPRWLPPALAGLLLLAVGATYEQRLRDARKLKDLLGRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z961</accession>
    <name>A0A7K2Z961_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000278">
        <property type="protein sequence ID" value="MYW28877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="337" mass="35250" checksum="07C44C27B9B15C95" modified="2021-04-07" version="1">APTGRTPRGTLLVADFGGDTVTFVDPGRDGSGEGGAPIASVEVGTAPYGLVVGEDGRAWVATAEGVAVVDTQRRTRLGTVPYETETGPVTTGEYRGGGMGIALAPDGRHVYVGVNVPGGNGTMEVIDTATREVTGVAGVGRRPFDVDVSPDGREVYATDHDSFDVTAVDADTLRTRRMEVAPYGTEGGLGSWLKPHYAVVRPQDGRLLLPFEGERLAVLDPRTGEVTVERMTADTHQHGAALASDGTLLVVGTGPIGADDEDPSLTVRAPDGKERIVPLDGPHEDVAVSADGRTAYVTGGFTRDGYWNGITVVDLRDEKNEPVRLEAGNRPLGIAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9L0</accession>
    <name>A0A7K2Z9L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000322">
        <property type="protein sequence ID" value="MYW29061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="301"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="497" mass="52842" checksum="7F3755FA29EF3D49" modified="2021-04-07" version="1" fragment="single">MTPEGEVSALVGRLGETGGGLWHPGRSGLPWMDAVHPKDRDGFAGKWAATARGDALLDAVVRIRQDGDPVRYRHIKIVAVPVLRDGEVLEWIGTVTDAEDQWRVRTRDRLLERASAVSSARDLPEAFAATASAVVPDLADAFVVFPLRHPDRARSGTEALYATRARTALATGVPPLPAITDDFALGALAREVIAGRRTRLLTFPPGEPPREMVSGPSVEWLVRARATSLAILPVVIDDRTVALASASSCLGNPPPGEAELGLLEEVLVSVQDPLRRTLELQSIRDTALVLQRSFLITPPRVEGAELAALYQPASTTAEIGGDWYDAIVLPDGALALSIGDVVGHDLRAATEMTKASSMLRAFAYAGGPAGPAHTLSRLDEVTQGVSDVALVTALHAVLRPAGGHRWDVTLSNAGHPPPLLVPASGRPRCLYGPEAPDPPLCVAAGVERHDWHHELAPGDTLLFYTDGLVERPGADISDGVRQLAERAAGLRGHGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9U3</accession>
    <name>A0A7K2Z9U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorismate mutase</fullName>
            <ecNumber evidence="3">5.4.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000336">
        <property type="protein sequence ID" value="MYW29098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010951">
        <property type="entry name" value="CM_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01795">
        <property type="entry name" value="CM_mono_cladeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="13825" checksum="B4CC44D0DEE44C77" modified="2021-04-07" version="1">MSTSENDAPASQRIDASVQAELNRLRESIDNIDAAVVHMLAERFKATQQVGRLKADHQLPPADPARETRQITRLRQLAQSANLDPAFAEKLLNFIIAEVIRHHERIAEEAGNGSADGHGNGGARAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA98</accession>
    <name>A0A7K2ZA98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000385">
        <property type="protein sequence ID" value="MYW29287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="22071" checksum="495104D22CE9EEEE" modified="2021-04-07" version="1">MNTEKVTARRLTAEEISSLGLQDDILVPVGMDGLPRECYAPAFLTKPGKNFEGGSFVARTAFGEEVHVLPENMEEGGIWIADKAGQEIEVLQSAGVLLNLALFVPNGSKESLELLYSAARDAFGAGVVQRWSEEVVKVPDAKVDLYEEPARGRKNTNSQNRDRRALDIYPTRVRFLEPSEGWKFVVEPHKEIIDETPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAA5</accession>
    <name>A0A7K2ZAA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000374">
        <property type="protein sequence ID" value="MYW29259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="22778" checksum="FB043E7E2647713B" modified="2021-04-07" version="1">MGIQDTPEEWQVTATVTPFTGNKTSVRTDQVVMPDGSVHGRDYQVHPGSVAILAVDEDDQVLVVRQYRHPVRQRLWEIPAGLLDVPGENPLHAAQRELYEEAHVKAEDWRVLTDVYTTPGGCDEAVRIFLARGLSAVEGERFAVSEEEADMEQARIPLPELVRSVIAGDLHNNCLVVGALALTAVLAGDGVDSLRPAEAPWPARPFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAD8</accession>
    <name>A0A7K2ZAD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7526" checksum="43DBAD154615BFD5" modified="2021-04-07" version="1">METVRAKVDKGLVRYDAWFLVFTAVILGLGATIYAGLVVWCVVYKNKSFTGSWSFKDFGLKVRAQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAJ1</accession>
    <name>A0A7K2ZAJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000400">
        <property type="protein sequence ID" value="MYW29322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="8218" checksum="C04F775CFB5E2F64" modified="2021-04-07" version="1" fragment="single">SREVAGWCVEDGALEEAVGTLERGRALALHTEMATVDVLSTLSRLGRADLAEEWRGWRDSARRRSEAGHRPDGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAM8</accession>
    <name>A0A7K2ZAM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin-6A reductase</fullName>
            <ecNumber evidence="4">1.3.1.106</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_08870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.106" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000407">
        <property type="protein sequence ID" value="MYW29389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="27212" checksum="32FC53BF9E218FE1" modified="2021-04-07" version="1">MMHVKHVLVLGGTTEARQLVESLVGDPRLRVTTSLAGRVAAPRMPPGDVRVGGFGGPDGLAAWVREHRVDALVDATHPFASTMSRNAVQAAAQAHVPLLALRRPGWVAQDGDRWHSVASLAEAAELLPALGERVFLTTGRMGLAAFAGEGLDALWFLVRSVDAPEPPCPRKMDVLLDRGPFSLDGEREIIRRYGIDVLVTKDSGGDATAPKLTAAREARIPVVVVRRPPVPEGVPVAATPEEAGEWVVRKLYASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAU7</accession>
    <name>A0A7K2ZAU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000419">
        <property type="protein sequence ID" value="MYW29459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23766" checksum="8B7B28F29A0488A7" modified="2021-04-07" version="1">MSQNTPANGKTPADFWFDPLCPWAWMTSRWILEVEKVRDIEVRWHVMSLAVLNEDKLDEVPEEYRDKLVKAWGPVRVVVAAQQLHGDEVVGPLYTALGTRFHNNGEGPTREAIAGALKDIGLPEDLLEYADKDTYDTELRASHQEGIDKVGQEVGTPVIAVPGADGEQVAFFGPVVTPAPKGEEAAKLWDGTLLVASIPGFYEIKRTRTQGPVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAY9</accession>
    <name>A0A7K2ZAY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000428">
        <property type="protein sequence ID" value="MYW29493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046416">
        <property type="term" value="P:D-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="PTHR11530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="20612" checksum="6C0FF6414D96E0E8" modified="2021-04-07" version="1" fragment="single">VYEELAAGPGGAGVRVVAGVHGGERFAALGPWAAELKGAVEVAEGLRVTLPLLDMPVHLAWLERRLVAAGGAVERRAVDGFAEAAAQAPVVVNCTGLGARELVPDAEVRAVRGQLVVVENPGITEWFTEADPASAATTYFFPQPAGLVLGGTAEADDERREPDAMTAREIVARCARVRPEIAGARVLGHRVGLRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB95</accession>
    <name>A0A7K2ZB95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_09665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000449">
        <property type="protein sequence ID" value="MYW29535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="306" mass="33906" checksum="FE540691C7B337E8" modified="2021-04-07" version="1">MQHGKYRFIVGFLVVPMALYVIFVIWPFIQSIYYSFTDWTGLSPDFKMVGFDNYTKMLDDDIFWKSLQHSVLLAVLLPLVTLGLALFFAFMLNVGGRRRKGAAIAGVRGSGFYKIAYFFPQVLSIAIVAILFQFAFDPAQGMINGTLKAVGFDDVPDWLGDPDLALWVIMGVLVWCTTGFFVVLFSAGMASIPKDFYEAALLDGASRFTTFFRITLPLLWDTVQSGWVYMGILALGAEGFAIVHIMSVGPGGPDYSTTVLPLYVYQSAFRDGQAAYATTIGVALLLVTLAFAAVVMRVGRRERLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBH9</accession>
    <name>A0A7K2ZBH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiazolylpeptide-type bacteriocin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000463">
        <property type="protein sequence ID" value="MYW29625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515646.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000463.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023895">
        <property type="entry name" value="Thiopep_bacteriocin_prcur"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03892">
        <property type="entry name" value="thiopep_precurs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="58" mass="5943" checksum="69F91E921AB18957" modified="2021-04-07" version="1">MAPKTELATLADEILELESETFEISDYSDAVEVVLAGSTSSSSTSTCSSTTSTTSCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBK0</accession>
    <name>A0A7K2ZBK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000484">
        <property type="protein sequence ID" value="MYW29688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="13469" checksum="C1175177BF1DBAE3" modified="2021-04-07" version="1">MRTDQTAMFVASRLYIDQRAAERAVYEHNRRVARALKGDALAAEPRLTLSGSTVMALSDYECQACRRSVGMAFAADSSTHRIVNRSGEPTRRTVSLCTRCWSDTVRHDGDEKKPGVEVSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBM0</accession>
    <name>A0A7K2ZBM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YigZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_10810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000492">
        <property type="protein sequence ID" value="MYW29757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018516115.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000492.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="22329" checksum="BA17585B29B4A8F7" modified="2021-04-07" version="1">MQEQYRTVARAGVHESEINRSRFLCSLAPAATEQEAQDFVARVRKEHPTATHNCFAYVIGADASVQKASDDGEPGGTAGVPMLQMLMRREVRYVAAVVTRYYGGVKLGAGGLIRAYGGVVGEALDALGTITRQRFRLATVRVDHQRAGKLENDLRATGRDVREVRYAEAVTIEIGLPDADVAAFTAWLADATAGSATLELGGEAYGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBP4</accession>
    <name>A0A7K2ZBP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000490">
        <property type="protein sequence ID" value="MYW29732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="23882" checksum="EC414943370EC929" modified="2021-04-07" version="1">MLIAGFPAGAWGTNCYLVAPAAGEECVIIDPGHQAAQGVEEALKKHRLKPVAVVLTHGHIDHVASVVPVCGAHDVPAWIHPEDRYMMSDPEKALGRSIGMPLMGELTVGEPDDVKELTDGSKLTLAGLEFGVSHAPGHTKGSVTFGMPEAADIPPVLFSGDLLFAGSVGRTDLPGGDHAELLSSLARVCLPLDDSTVVLSGHGPQTTIGRERATNPFLNGLDASPRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBQ1</accession>
    <name>A0A7K2ZBQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000493">
        <property type="protein sequence ID" value="MYW29763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="108" mass="11909" checksum="34185C1D33F7DE89" modified="2021-04-07" version="1">MTTTEQPTLDGTVPPEPVDYETWLAVVWPVFIAAAATGKVFTCYSVADEHKLPNPPKPQAQWGRLMTLLRDEGYIRTAGWACSDRPTTHHSGVRTWKGTAATRREAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBV9</accession>
    <name>A0A7K2ZBV9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ORF">GT040_11015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000499">
        <property type="protein sequence ID" value="MYW29798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="88"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="354" mass="36704" checksum="DFD377C10D740F82" modified="2021-04-07" version="1">MNVVTPSGGDSVADRSWPGLLNPLLRGENLSTEETAWAMDRIMSGEATDAQIAGFAVALRAKGETVEEVTGLVRAMYAHANTIHVPGRTVDIVGTGGDLAKTVNISTMSAIVIAGTGAKVVKHGNRAASSASGSSDVLEKLGVNLELTPQRVVEVAEAAGITFCFAVKFHPALRYAAKARRELGAQTTFNILGPLTNPAQVRSQAIGVADARMAPIVAGVLAERGNSALVFRGDDGLDELTTTATSRVWVVRDGTVREEPFDPRDVGLPLVPVEALRGADASYNADVARRLLDGEGGAVREAVLLNSAAALVALDPGPGTLTEQIAAKIQVAAEAVDSGAAKRALERWVAASNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBX3</accession>
    <name>A0A7K2ZBX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000493">
        <property type="protein sequence ID" value="MYW29765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="275" mass="30319" checksum="B1ED6D359AB1275B" modified="2021-04-07" version="1">MTTRTPVQHGERRCYLRGCRLPECLDANYRYMSRLRLDYQRGTARRTDAKPVRAHINQLLDAGWTQAQIERATGVGHRTLSPLRMDNCANVHTTTARRLLALPIGPPPAGETDTDATGTIRRLQALAAIGHSYAAIARHVGIHKDALGVIARGDRTQVRVETAKIVTAVYRHMSRAAGSSARSRFNAARLGWHGPLAWDDTTIDDPSAKPEADEPQTLNRDQLAAIRRADVEHLDGFGVSVEEIARRLGMAESTVKGIVKELRAGERRDRSKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC69</accession>
    <name>A0A7K2ZC69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000547">
        <property type="protein sequence ID" value="MYW29956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029724783" evidence="2">
        <location>
            <begin position="34"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="529" mass="57115" checksum="E2EC34B5AD3E50D0" modified="2021-04-07" version="1">MPPPYRRALTRALALTLAVASVTLLGPAAPAVADDIPKAPGHRLVSDYQGAPATASPVPGQAPPQHPYLAPNGRSGMHADAAGSGTHPYSGPLGRNPDVVSEKIAPVGGECATATFDTAGRLITVCGTFTGFLLKLLDPRTLDTLAEYKLPQRSSTVEAITRLDFPKIFKDTSGGAYFYLDDQDRVVLADSRQHVLRIAHRQNAAGRWEFTVENDWDLTGQVPHDCVSWTNLFPSGTCDPVTSVMPDWQGRIWWVTRLGRVGTVDPETSLIRSVRLTGEEIQNSFSVARDGVSIVSDHALYSFTATPDGTPRIQWRQTYDRGTGTKPGSVNQGSGTTPDLFGTGEEYVAITDNADDRMNVLVYRRGTDVPADRRLVCSVPVFGSGRSTTDNSLISWGNSLVVENNWGYENPTSLLLGRSVVGGVTRIDVRPDGSGCDTVWESTVRSPSTVPKLSTANGLLYFYEKEPNALGIDAWYLTAVDFRTGERRWRKLTGTGPAYDNNWAPITIGPDGTAYAGVFNGIVAVRDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCB9</accession>
    <name>A0A7K2ZCB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000555">
        <property type="protein sequence ID" value="MYW30007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="35658" checksum="171F0C6C372CCCC0" modified="2021-04-07" version="1">GKRMRPRLLWWGMRACGAEDAGSTAAALRLGVALELIQTCALIHDDVMDRSRLRRGKPAVHIGLAARAGLSPDSERGSAFGTSAAVLAGDLALAWADDTVAETALPAPVRRRIGAIWRSLRTEMVAGQYLDLHGQATGGSSTARAIRTACLKSALYSVERPLAIGAALADADEHTTAALRSAGRCAGIAFQLRDDLLGVFGDPARTGKPSGDDIREGKPTYLLAIARERAEAAGDEGALAVLGHAVGNADVTEGDLAGVRGVFEATGARAHVERKAERLRDHAVRRLGEAVDVDTHGGRQLLGLLRTVSGDPSGVGPATPDDPGGHHSPAAAGVLYAAEGGHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCK2</accession>
    <name>A0A7K2ZCK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_12605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="488" mass="49858" checksum="76EEA3A9FCD94B86" modified="2021-04-07" version="1">MAAEPRFRKDADAAAPDVTDDAVTAAEAAGADRKHPVDETLPPLKMFTSGLQHVAAMYAGVVAPPLIVGPAVGLTAKETAFLMGASLFTAGIATLLQTIGFWKVGARLPFVNGVSFAGVAPMIAIGKDRGHDGIAVIFGAIIVASVLGFLLAPYFCKLVRFFPPVVTGTVITLIGVSLLPVAFNWSQGGNATADDYGSMTNITMAAVTLVIVLALRKLLRGFLQQIAILLGLVIGTLIAIPAGITDFSAIKNADVVGFPTPFAFGGPQFEIAAIISMCIVMLVCMTESTADMLALGKIVGRPADEKIIEGGLRADTLGSAISPIFNGFMCSAFAQNVGLVAMTKIRSRFVVAAGGGILIVLGLVPVAASVIALVPLPVLGGAGIVLFGTVAASGIQTLATAAMEKGENALIVAAALGIGLIPIAAPQFYHAFPESLLVVLDSGISTGCVVAIVLNLAFNHFGRKPDGVDEEAENGEHVVPAAAGVGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDE7</accession>
    <name>A0A7K2ZDE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000650">
        <property type="protein sequence ID" value="MYW30295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="172" mass="17804" checksum="8E619A5E63F34EB0" modified="2021-04-07" version="1" fragment="single">MTRTIEASGTAATAAERPSSERTLRQRLRRWTSAPAYAGLTGGVLTLFAAVELLLVPGSAITAFAVLVCTASLTLRAAHPAVGLLTVGAALLGFATDGNMAYATVAGLLMGCYTLGRQRVQHPAVLVTGGSLAALTVNLVHIDRWARDGSPGLPVLQGTDRFSLGLYAETLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE38</accession>
    <name>A0A7K2ZE38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000714">
        <property type="protein sequence ID" value="MYW30545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23531" checksum="161A8B87172B97A9" modified="2021-04-07" version="1">MESVLTEAVALLDEAGPSALTFRALAQRLGGGVASIYWYVASKDELLDRATDHVIGGVLAEVEAIEPGDDPIDHLRAMSLTLFDAILVRPWLGNYFMRNTDVQGNALRLYEKLGQPTLRLELTARQRFHAVSAITTVVVGSAVDLGQEPPQEVLDGALGRDEFLGRFAATWRDLDADDFPFVHEIVDEFDGHDDIEQFRAALDLTLAGLRLQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEC1</accession>
    <name>A0A7K2ZEC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000734">
        <property type="protein sequence ID" value="MYW30700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="18239" checksum="10882F978A63586B" modified="2021-04-07" version="1" fragment="single">MEQGSAREGVRPPYGPGAYAGTPATGRVPEQMRGGRSQDAPLARGEHTHSEPPAPRVIRHSVRGQILQALRAALVDGELTPGQVYSAPALGARFGVSATPVREAMQQLATEGAVEVVPNRGFRVSERGPRELAELAEVRALIEVPVMLRLARTVPAERWSALRPLADATVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEH9</accession>
    <name>A0A7K2ZEH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Excalibur domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000739">
        <property type="protein sequence ID" value="MYW30719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008613">
        <property type="entry name" value="Excalibur_Ca-bd_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007331">
        <property type="entry name" value="Htaa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05901">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04213">
        <property type="entry name" value="HtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00894">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029747027" description="Excalibur domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Excalibur" evidence="3">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="535" mass="53380" checksum="FE2A60705E3705C0" modified="2021-04-07" version="1" fragment="single">RPIALAAAVATAAALGATFALPAFAADGARAETAADAPAAAGAPAPSVFKLESGTLDWGLFSGWRDMIGKMGTATLADGVTQNADGTYKFPLDKGEYDVGNHGVTSSFKGSVHYEAHGGILDIKLSDFKVVTVGKTGKITVDVTTKSPGKEPVVSDDLAMVTLDLDGVDPANGAEGMKFADIPTAFTKEGGAVFLHYTEGMPADPATLAVKPAKPPVEPPPPVDPPVKPPVKPPVKPPVKPPVESDPIDAAKPTSGPVVDGTLDWGLKKSFRSYVVGPIAQGKVETSDGATANADGYRFTKATGHLDAEKNSLDAQFQGKVRFLGHETAGAYKLDLSLSNLKIDIQGTKGTLIADVSSKDMTSGEVDTSTGLAFADLKVPAGALAAKEGIVTLKNIPATLTEEGAEAFIGQYQKGDELDALNAAVSLDKNATLPPGGSTDYENCAAAEAAGVTPIKKGEPGYAAHLDGDGDGVACESGESGGSGSAGGSTTGGSTTGGGTVGGSTTGGSTTGGSVGGSGALAATGSDVPTGALIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEI4</accession>
    <name>A0A7K2ZEI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000756">
        <property type="protein sequence ID" value="MYW30742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029509494" evidence="1">
        <location>
            <begin position="26"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="25119" checksum="D2C13FDC2770D751" modified="2021-04-07" version="1">MRRRSLPTFAVLLTLALGSLGAAPADGPPPLPYRLADTGGGSQLITAEAPDTASTTGTVTWWERRGGRWMAAGSAPARFGANGLADGATREQGTSTTPTGLYDLPYAFGIQEAPAGTRYAYRKVNEDSWWCQDNASASYNRWVEPRPADCRADEAEHLVSYGTQYAHALVIGFNYERPVRNRGAGIFLHVNGRGATAGCVSVPADAMAEILAWADPERRPHIAVGTTSGPTAITQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEW6</accession>
    <name>A0A7K2ZEW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000774">
        <property type="protein sequence ID" value="MYW30876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="2">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="292"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="381" mass="41426" checksum="DB446DC3939AD35D" modified="2021-04-07" version="1">DVPLLGPRHIHAKVNSVYALQREVLAGRARDLRQALEEGTAPDASADWYDGVRKADRALRSASPSVGRPYVWASQLHMLFNRLGLAPDEERAVCRLAARTLLDRGEAASYFPDDHTSPDRQYLERSKFHLGREQDSAPRDVPAVRALPAQSAGSSRGAELPLPAGPFPDADLRTVMNSRVSRRGSLTGPLDAASLGTLLWGAHASGHESVHRFVDGGERLVRHRPYPSAGALYTAGLRLIALDVQGLAPGTYQCLPDRRALRYTGPAPALDDIRSLSSYLSRADDDPDGIVPDTLPVVLGLYVDLGRLRERYGLRALRLGLLEAGHLAQSLLLTATALRLGSTPLGGFRDDLAHEIFGLDDLDQPLQYVLPVGRHPEMPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEZ8</accession>
    <name>A0A7K2ZEZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000788">
        <property type="protein sequence ID" value="MYW30906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="2">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="16518" checksum="10CB4CFA84E31066" modified="2021-04-07" version="1">VPRRLHELWVQVTGATEDLTTAHGRSPTTAEIAERLKISEDEVLACIEAGRSYHATSLEAAQEGDGLPGLLDRLGYEDPALAGVEHRDLVRHLLVQLPEREQRILLLRYYSNLTQSQISAELGVSQMHVSRLLARSFARLRSANRIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGE3</accession>
    <name>A0A7K2ZGE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="19350" checksum="336A89744CFF6C2A" modified="2021-04-07" version="1">MTSTGQRPLLFLDVDGPLIPFGGTPQQYPQGYPRYRSPSGPRSAEANPLLTRINPAHGPRLGSLGYELVWATTWMADANDCIAPWLGLPPLPVVSWPDEPPAGVERDGLHWKTRTLADRAAGRAFAWVDDEITETDRAWVEGHHRGRALLHRVDPHHGLTEADFAALTAWRDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGE4</accession>
    <name>A0A7K2ZGE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000912">
        <property type="protein sequence ID" value="MYW31410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="317" mass="34913" checksum="5B680E3FF72BB9FF" modified="2021-04-07" version="1">MGRPQKEIVLDGSPTRLFAYWLRDLRGSAGLTLEQLARRTGYGRTTVSDAMQGNTHPSRPVTLAIVGACGGDVRRWGEYWAQVRRALDPDSPDGPDGVVPPPWDGPAGRTAGVHTEQCPADCARTDPHGWYTESVSTQLRLDTPTPEAWERRVVVATCDGLDRIPVGVSVPRRTGDTTRGHGLDISLVRGGRLADGVPQYESYFERFLVLPEPLRAGTRHVYELRLRIPPAQPMAPHFVHVPLTRSEHFRLRVSFDRARLPRTVWRLAGVPTAVIYQHDPGTPALRPDERGLVGVEFGAMMVGYGYGLCWLEAGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGJ0</accession>
    <name>A0A7K2ZGJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_19915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000928">
        <property type="protein sequence ID" value="MYW31481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="7825" checksum="CD9B771A062B357E" modified="2021-04-07" version="1" fragment="single">MRRATCEFGLTALMLLAVVSGVRWLFAPDGYGGGGVAFALLGAGVGVLLGALMLSAPGRWSGGHLNPAVTVALWRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH29</accession>
    <name>A0A7K2ZH29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000972">
        <property type="protein sequence ID" value="MYW31618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="13344" checksum="5A33803172071D29" modified="2021-04-07" version="1" fragment="single">MSPAVTDGSADPRTARTRAKLRAALLAACEHRPLEQVSVAQVVRGAGVGRATFYLHYDDLHALAVDACAEVVTEAVDALHAWDGAPPGPDAPPAPLAALLTSVHTRAPVYRSLLREGGGGPLGELLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHA3</accession>
    <name>A0A7K2ZHA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001006">
        <property type="protein sequence ID" value="MYW31730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8674" checksum="8DA687591BC612C0" modified="2021-04-07" version="1" fragment="single">MQTARTVPAATVVNLRDLGGIALGRDHRVRQGVLFRSGQLSDLDPGRDRAVAALGIRTVVDLRTADERQWSPDRLPDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHE6</accession>
    <name>A0A7K2ZHE6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative phenylalanine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisC</name>
        <name evidence="3" type="synonym">pat</name>
        <name evidence="5" type="ORF">GT040_21495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the transamination reaction in phenylalanine biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01513">
        <property type="entry name" value="Phe_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024892">
        <property type="entry name" value="Pat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="359" mass="38395" checksum="33CC11926D787C7A" modified="2021-04-07" version="1">MSETSPKLRAELDGVPAYVPGKPAAAGGPVAYKLSSNENPYPPLPGVLESALAAAGSFNRYPDMACTGLMNELSDRFGVPLSHLATGTGSVGVAQQLLQATSGPGDEVIYAWRSFEAYPIITQVSGATSVKVPLTSGEVHDLDAMAAAITDRTRLIFVCNPNNPTGTVVRRAELERFLDRVPSDVLVVLDEAYKEFIRDADVPDGIEIYRDRPNVAVLRTFSKAYGLAGLRVGFAVAHEPVAAALRKTAVPFGVSQLAQDAAVASLRAEDELLGRVGSLVSERSRVSEELVRQGWTVPESHANFVWLRLGERTLDFAAACERAGVVVRPFKGEGVRVSIGETEGNDLFLKAAEAFRAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHH7</accession>
    <name>A0A7K2ZHH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001019">
        <property type="protein sequence ID" value="MYW31811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041635">
        <property type="entry name" value="Type_ISP_LLaBIII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18135">
        <property type="entry name" value="Type_ISP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Type_ISP_C" evidence="1">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="164" mass="17582" checksum="D27FE591D138592A" modified="2021-04-07" version="1">PRLPGGRRPYVRAALPARPTGIVYDAEAEALVIGDGRISPVPAGAWEFTVSGVRVLELWFDRRTAAAVGAVPEDVEADGLEGVGARGWTPEWTSELLELITVLALLDGLRPRQEALRARLEQAPLISRDELRAAGVLPVPASVRRPASVLGHQEEGPEGQFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHL2</accession>
    <name>A0A7K2ZHL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ugpC</name>
        <name evidence="6" type="ORF">GT040_21805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001023">
        <property type="protein sequence ID" value="MYW31840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="378" mass="40420" checksum="E6815FB31D099F97" modified="2021-04-07" version="1">MASVTFDKASRVYPGSTKPAVDQLEIDIADGEFLVLVGPSGCGKSTSLRMLAGLEDVNGGAIRIGDRDVTHLPPKDRDIAMVFQNYALYPHMSVADNMGFALKIAGVNKTDIRAKVEEAAKMLDLTDYLDRKPKALSGGQRQRVAMGRAIVREPQVFLMDEPLSNLDAKLRVSTRTQIASLQRRLGITTVYVTHDQVEALTMGDRVAVLKDGLLQQVDSPRNMYDRPANLFVAGFIGSPAMNLVEVPITDGGVKFGNSVVPVSREALSAAADRGDTTVTVGIRPEHFDIVEHGGAAAKALTKDASDEPAGLAVSVNVVEELGADGFVYGAAQVAGEHKDLVVRVGGRAVPEKGTELHVVPRPDELHVFATSTGERLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHT8</accession>
    <name>A0A7K2ZHT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_22275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001060">
        <property type="protein sequence ID" value="MYW31926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="353" mass="38395" checksum="F09E99B385062BB9" modified="2021-04-07" version="1">MTTLTKTEDKPAPTGPEGFLSVRDLRVRFSTEDGIVKAVDGLSFDVERGKTLGIVGESGSGKSVTNLAVLGLHNPQSSQVDGEILLEGKDLLKSSEKEMERLRGNKVAMIFQDPLTAMSPYYTVGRQLSEPFRKHTGASKKEAKARAIEMLTKVGIPQPATRFDDYPHQFSGGMRQRAMIAMSLMCDPDLLIADEPTTALDVTVQAQILDLLKDLQQEFGSAIIFITHDLGVIANMADDLLVMYAGRAVERGSVSEVLRAPQHPYTWGLLSSMPRLAGDISEELVPIPGSPPSLLNRPTGCPFHPRCAFTDRVEGSLCSGERPLLPEGRGAACHLTQGEKQSIFIDQIKPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHX2</accession>
    <name>A0A7K2ZHX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001059">
        <property type="protein sequence ID" value="MYW31915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="27502" checksum="DC72978AAF006129" modified="2021-04-07" version="1">MGNWWHTNIAEPGKLPLLLALAAFVLTFAVTRTITRLIRAGKGPFRNITPGGIHIHHVVPGVVLTVVGGFGAVAAGRHGVAAGVFAVIFGVGAGLVLDEFALILHLDDVYWTEEGRQSVEVVVLTASLVLLVLAGFSPLGVDDVTDEEQQGRLGVITSYVINFCFVLIALFKGKTRMAVLGTLVPFVALIGAIRLARPTSMWAKRFYRNRHRARSKAVLRAYHHDVRWAGPRRKFQDLIGGAPDRVPLPPAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIM5</accession>
    <name>A0A7K2ZIM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001111">
        <property type="protein sequence ID" value="MYW32202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="23781" checksum="4E08BB55E2BB7D6F" modified="2021-04-07" version="1">MSSAPPDPGIEASLASVDAWLTDYIAMNHPEIGRVGPICPFVTPSRKNDSMEIRIRLLGFSPTAELVEEVARSGLREYELTTWQGRNPMLRAMVIVLPDLRSEDTPLLDRAQEQVKDAFVSRGLMIGQFHRNCDVTAARNPRFAVSRAPVPVFAIRSIALHDIFFLAERRHWFEKYRERFGMYFGAQVAAMDPLLVDCYRSAEKEFGYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIY7</accession>
    <name>A0A7K2ZIY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001131">
        <property type="protein sequence ID" value="MYW32285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="23540" checksum="C38D41999E8312DC" modified="2021-04-07" version="1">MGEFLDAALSFPAVIFGAALVVVVCFWLLVLAGAADQHSFDSDLDSGTVGFGGVPVTVSVSLLVVVAWFGSLSGAVLLHRVPVAGTTRAVLAVAVLAGSLFLAWGTVRLLAHLFRRYFPAEPPPSRQDFVGRVCTIRTGSVSAVFGQAEVAAADGSTAIVQVRQAPRVALLAELHAEEILVSGSTGLLYAYDEEGEFFWVSPYDAALDPGPKAKPGGLGLPEGTTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ01</accession>
    <name>A0A7K2ZJ01_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="12" type="ORF">GT040_24465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001150">
        <property type="protein sequence ID" value="MYW32336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030569653.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001150.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="171"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW32336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="391" mass="42583" checksum="AADDA8C9E1252E6E" modified="2021-04-07" version="1">MSSENLPQSPERPESPEQQRRKPRVAVVFGGRSSEHGISVVTAGAVMKAIDRTKYDVLPIGITTDGRWALTADDPERMAITDRKVPDVDRLTESTEGSVVLSVDPGSREVVYTEPGSVPKALGEVDVVFPVLHGPYGEDGTLQGLLELSGVPYVGAGVLASAVGQDKEYMKRVFISFGLPVGPYEVVRPREWDRDPSAVRKRIVDFAGEHGWPLFIKPARGGSSMGITKVDELSGLDAAIEEARRHDPKFLVESLLRGREIECGVLEFEDGPRASVPAEIPPVTAHEFYDFEAKYIDSAAGLVPAPLTAEETAEVQRLAVAAFDATSCEGLVRADFFLTEDGTFVINEINTLPGFTPISMYPRMWQESGVSYPELVDRLIQAALTRSTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJB3</accession>
    <name>A0A7K2ZJB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl/propionyl-CoA carboxylase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001165">
        <property type="protein sequence ID" value="MYW32428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="15551" checksum="613E098F14744EC6" modified="2021-04-07" version="1">GVRAPLAFPLRVSGADPVAYEAPAGAVVTPDRVTVELDGAVGHFHRSGDWLGRDGDTWHVQDHDPVEASLSGAGRSGADTLAAPMPGTVTVVKVAVGDEVEAGQSLLVVEAMKMEHVISAPHAGTVTELDVTAGATVAMDQILAVVAPREDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJD2</accession>
    <name>A0A7K2ZJD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">atpE</name>
        <name evidence="15" type="ORF">GT040_18355</name>
        <name evidence="16" type="ORF">GT040_25050</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000861">
        <property type="protein sequence ID" value="MYW31182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001174">
        <property type="protein sequence ID" value="MYW32448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966254.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001174.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6213175"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW31182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW32448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="7811" checksum="554E7448183294DA" modified="2021-04-07" version="1">MSAAFETLAAVNGNVGTIGYGLAAIGPGIGIGIIFGNGVQAIARQPEAAGLIRQNMLLGFAVVEALALIGFVVPFIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJD3</accession>
    <name>A0A7K2ZJD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tsaE</name>
        <name evidence="7" type="ORF">GT040_25080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001174">
        <property type="protein sequence ID" value="MYW32453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="19284" checksum="689884A0ED46B257" modified="2021-04-07" version="1">MEAAHSSPAAETVPGAPTDLPEAVTVTITVESPEQMQDLGRRLARVLAPGDLVMLTGELGAGKTTLTRGLGEGLGVRGAVTSPTFVIARVHPSLVEGPALVHVDAYRLGGGLDEMEDLDLDVSLPESVVVVEWGDGKVEELSEDRLRVLIDRVTGETDDERREVTLVGIGDRWKGLREDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJN4</accession>
    <name>A0A7K2ZJN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001198">
        <property type="protein sequence ID" value="MYW32555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="223" mass="23402" checksum="445BE85DFCD5C08D" modified="2021-04-07" version="1">MAAGAAIFDVDGTLTDTNHLHVVAWWEAFRQAGHTVPMPDIHRAVGLGSDDLIERLLGPDRDRDQDSVISSAHKVLYGTYVDRLPAFAGAGDLLRTLAGRGWRVVLATSASGPELAALRRAVDADEAIRDTASSDDVDEGKPSPEPVELALELTGTDAGQGVFVGDTVWDMEAASRAGVRAVALLSGGIPQADLEAAGADAVFRDVADLLAHLDDSPFAPERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJT0</accession>
    <name>A0A7K2ZJT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CsbD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001203">
        <property type="protein sequence ID" value="MYW32610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="57" mass="6040" checksum="6C7738C0017BE554" modified="2021-04-07" version="1">MAADEKAQAKTEQGKGKVKEAAGRAVGNERLTAEGRADQAKGDIRQAKEKVKDALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK04</accession>
    <name>A0A7K2ZK04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001218">
        <property type="protein sequence ID" value="MYW32671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="16100" checksum="A8292EF8E1063A4C" modified="2021-04-07" version="1">MTTTGSTAAASTAAPAPAPAATARELGLAHYAARGVLEYVLARHGATFAQQIALRAAISADAPQTPDGLVAQVQGSLKADPAGIRSVLDELLAKELLVADGEHLRPTEAGRELHAAVAAETAPISARVWGGIPAEDLAAAGRVLALVTERADAELAALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK15</accession>
    <name>A0A7K2ZK15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobA</name>
        <name evidence="10" type="ORF">GT040_26280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001222">
        <property type="protein sequence ID" value="MYW32685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012409">
        <property type="entry name" value="Sirohaem_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036426">
        <property type="entry name" value="Sirohaem_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="9">
        <location>
            <begin position="182"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036426-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="430" mass="44970" checksum="D9BAA608BD81C80D" modified="2021-04-07" version="1">MAEHADHADRAGQNDHPAYPVGLRLHGRRTVVIGGGQVAQRRLPQLIATGAVITLISPSATASVEAMADAGEIRWERRRYQDGDLADTWYALVASSDTAANDAASAEAERTRTWCVRADDAEAATAWTPATGRIDNITVAVLNTTPQGRDPRHSAALRDAIVEGLRDGTIAAPHHRNHTPGVALVGGGPGDPDLITVRGRRLLAEADVVIADRLGPRDLLDELPPHVEVIDAAKIPYGRFMAQEAINQALIEHAKAGKAVVRLKGGDPFVFGRGMEEAQALAAEGIPCTIVPGISSTISVPGAAGIPVTHRGVAHEFTVVSGHVAPEDPRSLVDWEAIARLRGTLVLLMAVDKIGAIAAALIAHGKDPATPVALVQEGTTAAQRRVDATLADVGERAVAEDVRPPAVIVIGEVVAVGPHSAPQQADPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK60</accession>
    <name>A0A7K2ZK60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Modular polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001243">
        <property type="protein sequence ID" value="MYW32718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="23576" checksum="388B0D03E9570A67" modified="2021-04-07" version="1" fragment="single">AMDPQQRLLLETAWETFESAAIDATALRGSNTSVFVGSMYDDYASRLASVPAEFEGFLLVGNTSSVISGRLAYTFGLEGPAVTVDTACSSSLVALHLAAQALRSGESDLALAGGVTVMAGPGSFVEFSRQRALSTDGRCRSFSADASGTAWSEGVGLLLVERLSDARRNGHQVLAVLRGSAVNQDGASNGLTAPNGPAQERVIRQALADAGLTPADVDAVEAHGTGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKV7</accession>
    <name>A0A7K2ZKV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001300">
        <property type="protein sequence ID" value="MYW32986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="549" mass="60376" checksum="F2BD2945F5AA1F00" modified="2021-04-07" version="1">MTGTPDVTVVVAVYNTMPYLTECLNSLVAQTIGEDRLQVVAVDDGSTDDSGRELDRFAEKYPDVFTVVHQPNSGGPAAPSNRALELATGRFVYFIGSDDHLGEEALERMVACADANESDVVVGKMVGTNGRYVHQKLYSGNRPDVSLYDSALPFTLANTKLFRRELVEKHKLRFPEDLPVGSDQPFTIEACVRARRISVLSDYTYYYAVKRGDASNITYRADHLARLRCTARIMDHTAGLIPAGPRRDAVLKRHFEWELSKLMLDDFPALPLETRREICAGLAALQDTYFTDALRDATGVKRRVRLGLAQRGAVAELTRAIADEAEHGAPPFLLEGDRAFAPYPGFRDAAIGLDDRWYEARETVSGRLADGTKLESAAWEQDGEDLTLALKVRVGITGDTSSAVVALAQGALPKSADKPGARKLPKDAERPEAVGEFTREPADDGTGTLLSARIPVDRIRAKRGVRAYVDVAGTTYEIPVRTDGLPMPLARRWGSTTPFRVSANPNAKGRLVITTAPLWEPKPDLGTRLRRTLSGLKRKLSRLKRKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKW5</accession>
    <name>A0A7K2ZKW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001273">
        <property type="protein sequence ID" value="MYW32889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6840" checksum="879B54B11F889968" modified="2021-04-07" version="1">MDAIQQHMLDTYRAARLGEPAPPPPGRHDRKTLRDLYHHWLTHPPTRHQSVRGHSSPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLA4</accession>
    <name>A0A7K2ZLA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CDP-glycerol glycerophosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001339">
        <property type="protein sequence ID" value="MYW33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16191" checksum="183F49CAEA7FBF88" modified="2021-04-07" version="1" fragment="single">QALHCYDRTGFEVVVSARRLRELAGRGAGQWFLHIGIPGPGGIHTARVRQRDAGTAGHNQVRHLADGSRLVVGFTKNAVSITVQQPPVEVESCTVADGELVLVARARSGAEVPTAVSVVEGDTGFDSPLTLLPGSSGSSGSADAFRRYRAVFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLB5</accession>
    <name>A0A7K2ZLB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1205 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001333">
        <property type="protein sequence ID" value="MYW33136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1205" evidence="2">
        <location>
            <begin position="193"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="382" mass="40734" checksum="FD7D6ED57689F9A1" modified="2021-04-07" version="1">MRVLFAVSPGFDHLYPSAGLAWAFRTAGHDVVVATSGVSTEAAAHSGLAVREVSPGADFAQFFPRSGTPGERVRAMRERGLTMAKTLRTPDIILEKFSGVGNLMLDGTLAFARAWEPDLIVYSRLNGAALVTARALGIPAVEHGFSFLREGTMPQRFLPHLEPLYARVGVPHELPEVTSLYFAPEHMMHGEGEGWTMRSVPYHGGGTLPDWMALPKERPRICVTLGTTVPYVAGVGSLGSVLAAAAEVDAEFVLALGDDPDLDALGTLPGNVRTVGWTPLSTLLTTCDAIIHHGGSGTTLASAHAGVPQLAIPHGADNWINADMIERNGLGLRRDAEQIDAQLLNTLLHDHDVRSGAHEARATLAAEPGPDLIVPRLQELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLD3</accession>
    <name>A0A7K2ZLD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001348">
        <property type="protein sequence ID" value="MYW33167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="172" mass="18888" checksum="44F344138EA0CD33" modified="2021-04-07" version="1">MVATASEVWADTAMGVPPRHVRDRTVKAAHGVAYSRGRSVYSEWSTDETEFFRPEDPPVQNSLPRALSIIDISSIRDADVAEQVRGERFGSLLQRLDCFDVARDFPDARRDGRRSGSVGQAVKASPLGRSRISSRSLYCYTSDLFPSFIGLREGASVMGIAESAAHRIIRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLP6</accession>
    <name>A0A7K2ZLP6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoC</name>
        <name evidence="4" type="ORF">GT040_29410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001361">
        <property type="protein sequence ID" value="MYW33271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="315" mass="33173" checksum="5DBACBE5446D5EE4" modified="2021-04-07" version="1">MPTTAPAFSDATASDSALRRFLFGLPGVDAVGLEARAAALGTRSIKTTAKAYAIDLAISMIDLTTLEGADTPGKVRALAAKAVHPDPLDRTTPRTAAVCVYPDMVATATAALAGSGVKVASVATAFPAGRAALDVKLADVRDAVAAGADEIDMVIDRGAFLSGRFLKVYEEIVAVKAECGTARLKVIFETGELSTYDNIRRASWLGMLAGADFIKTSTGKVATNATPANTLLMLEAVRDFRAQTGVQIGVKPAGGIRTTKDAVKFLVLVNETAGEDWLDNHWFRFGASSLLNDLLMQRQKLSTGRYSGPDYVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMA7</accession>
    <name>A0A7K2ZMA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_30450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001401">
        <property type="protein sequence ID" value="MYW33472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="14348" checksum="3B72DFA07F8A641B" modified="2021-04-07" version="1" fragment="single">MVTTTVAFIGLGHMGGPMAANLAKAGHRVLGHDLVETSLATAVESGVERAKSAAEAAAVADVVITMLPAGRHVLSLYGQEGLLAAARPGTLFVDCSTIDVADSRAAHAAAAAAGHRSLDAPVSGGVVGAEAGTLTFMAGGEEAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMC6</accession>
    <name>A0A7K2ZMC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Export associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001411">
        <property type="protein sequence ID" value="MYW33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8040" checksum="65093CF731F4437F" modified="2021-04-07" version="1" fragment="single">MTAELVRGQNHALPQTRLEIRVSAGSPVVAGATLGDENGVVRGAEWIAHPGSPQLPGLEVSQQAAAGHRLAVDLEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMG5</accession>
    <name>A0A7K2ZMG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001409">
        <property type="protein sequence ID" value="MYW33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029756960" evidence="2">
        <location>
            <begin position="39"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="295" mass="30717" checksum="94F51249D7569285" modified="2021-04-07" version="1" fragment="single">MSPTSCARLRDARALAALGLAAGIAVPAALLGGPQAVAHPTPASLAAGIAADAAADEQPTCGDPGAEEFPVEARIQEAPTTYASGGGYGIWFLDLTNTTDAACHALHPVLVLNDEDRKLTTGQIQLKFSEPGRPGTEHRVTWETTDRHEQIGVFDGDPGSTAADDFLGFTVPAGATVSVRVEMAFASDTAPGRVTAHAAVVQRRHQDKAKGGGREDGDWVGESGAYRFVIVDGVTGEYPRPEATDEDRDGRTDVPAEPRPRTEPTSAAPTPTRTHTSAPTPDHTGPAKEPAPHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZML9</accession>
    <name>A0A7K2ZML9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001435">
        <property type="protein sequence ID" value="MYW33572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="22541" checksum="FB4B7DD6E1696F2E" modified="2021-04-07" version="1">MGRRLVPLTLDNLQDLPERCRACVFWELDPVSGEAAVKAGKPEPEKEAWISAVLLEWGSCGRVIYVDDIPAGFVLYAPPAYVPRSTAFPTSPVSPDAVQLITGLIVPGYQGQGLGRVMVQTVAKDVLRRGFKAIEAFGDARAEAFGCLLPADHLLAVGFKTVRPHPRYPRLRLELRTTLSWKEDVEMALDRLLGAVQKEPALRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMX1</accession>
    <name>A0A7K2ZMX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001444">
        <property type="protein sequence ID" value="MYW33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="23269" checksum="7BA65ADA7EAE9C06" modified="2021-04-07" version="1">MSAIEQTEAARPRGTRLPRRARRNQLLGAAQEVFVAQGYHSAAMDDIAERAGVSKPVLYQHFPGKLELYLALLDQHCESLLQAVVTALASTTDNKLRVEATMDAYFAYVEDEGGAFRLVFESDLTNEPAVRERVDRVSLQCAEAISDVIAGDTGLSKDESMLLAVGLGGVSQVVARYWLSSGSSIPRDTAVQLLTSLAWRGIAGFPLHGVDQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN91</accession>
    <name>A0A7K2ZN91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001484">
        <property type="protein sequence ID" value="MYW33826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="49"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="16162" checksum="1B4AAEBF762B9B84" modified="2021-04-07" version="1" fragment="single">MGPTEQGTGRGGAAAPAHSQGEPGIAPTRDGRDLYYQRLAGPAGSETVPTVVFEGGLAAGRSYWASVQAALTDVAPTVVYDRSGLGRSPAAPAGVSRRLPALADDLGDLLDHLGPQGPYVLVGHSWGGPLVRLAAAARPARVAGLVLVDPSDEACELLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNC9</accession>
    <name>A0A7K2ZNC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">lipB</name>
        <name evidence="12" type="ORF">GT040_32410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030564319.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001485.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="35"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="30699" checksum="B2A9B2002447E791" modified="2021-04-07" version="1">MSELRFVRLGFGDEAVEYTEAWQKQREVHAARFEDLVPDTCLLLEHPPVYTAGRRTAENERPLDGTPVIDVDRGGKITWHGPGQLVGYPIQKLPRPVDVVAHVRRLEDALIRTAADFGVETSRVEGRSGVWVLGDPVEERRTLGGLSLDFDPRLQDEEFDPRLNGPEYAPSNAGQRREDRKLAAIGIRVAKGVTMHGFALNVNPDNTWFDRIVPCGIRDAGVTSLSNELGREITIEEVLPVAEKHLRDILENAELAPRVIEQPAERSAGQPKAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNH3</accession>
    <name>A0A7K2ZNH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001494">
        <property type="protein sequence ID" value="MYW33911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="34528" checksum="8BA57CEAE33221E9" modified="2021-04-07" version="1">MHLSFVPPRRVKIGDAAAFVGTTPRAIRHYHAIGLLPEPERGGDGRRRYGHQDMIRLLWIRRMAGAGIALDDIRDALTADTGAVGDDRGDGGGGGEGGDADGGDGIALTLENSLAAQEAVLRRQRTAVQRMRAEGSRMGLLSDVVTDRFKSLPEGPPRQGELDTLLVTERIFGPLGAAVQATRFIALATHPALREESDRVDAAEESLDDTVAVDDPRVARVAAERHAFEGALDAFIEESGLAGDDDALFGAWDVPDPATTDQEEEEEEEEDDGGGGDRGCGGRRARTMSAFEAVGRMPYDFSPARLRCMELAEQLAAQDAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNS0</accession>
    <name>A0A7K2ZNS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_33175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001512">
        <property type="protein sequence ID" value="MYW33995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW33995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="349" mass="35948" checksum="86880BF8AEF069EE" modified="2021-04-07" version="1">MHSAGQRSGVAYGATADEAAPVAAENEPHLRGSPLFTPLLLLGAAVLPGTLVVVIGLWGDAPAVQAWRNVCLSISVQALPFLLLGTALSGAINAFVPARVFDRALPRRPALAVPVAGAAGIVLPGCECASIPVANSLIGRGVTPAAAFAFLLSAPAVNPVVLTTTAIAFPGDPSMVVARLLASLATAVVMGWLWLALGREKWLRPTVRHTGHQPGHSRWTEFRLGFQHDFLHAAGFVVVGAMAAATFNVAVPQSVLDTFSDSPWVSVLFLAGLAILLSVCSEADAFLAASLTGFSPVARLVFMVVGPMVDLKLIALQAGTFGRAFAIRFSAATAVVAILCGTLVGGILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNT1</accession>
    <name>A0A7K2ZNT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001523">
        <property type="protein sequence ID" value="MYW34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="7045" checksum="27CE3FA3B58BFD19" modified="2021-04-07" version="1">MSAMDKIKKMLKGHEDQAGKGVDKAGDMVDDRTKGKYSGQVDTAQDKLKQQFGTERDQDGPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP28</accession>
    <name>A0A7K2ZP28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8254" checksum="DC08C9E1F26B6C69" modified="2021-04-07" version="1">RHLGAAAAARDTVGLPLPDGERHDVDRIAARAVEVLGRAAYETLFAGGGERAEQLLGQGERFLGRAEQSLGQAEPFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP36</accession>
    <name>A0A7K2ZP36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001545">
        <property type="protein sequence ID" value="MYW34116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="30090" checksum="E087CFD443DFE600" modified="2021-04-07" version="1">MSPGDEHDYRGMDQGGRADDPYSTLGGTRQTRTRLPDGDAGHPHTRRPVRNSRSLVTITGVVVLLIAAIAFANRGGTSNDDSASPGTRNPGTAGSAPTAATGTKPVQGKNGTIASGFAQDEQGAQSAAANYAVALGSAEMFDAESRRGIIEATHDPAVAQGLQDNLDKAYSPAFYKNVGLNDDGSTPTGLTFVSRTVPVGTKVVKMETETATVEVWCTGLVGMAGQGSTKPVTETWFTISQELKWVGGDWKISSSSQAEGPTPVNGDNRASTADEMAGAVDAYGGFTYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP58</accession>
    <name>A0A7K2ZP58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_33460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001539">
        <property type="protein sequence ID" value="MYW34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029623720" evidence="1">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="17850" checksum="F319B8C6E0D55F07" modified="2021-04-07" version="1">MKSKKLLAVALGAGIAPLLAVTLPTGSASAHGYISSPPSRQAQCAAGTVSCGAIKYEPQSVEGPKGLTSCSGGNAAFAELNNDSKGWRVTPVSRTTSFNWRLTARHATSTWQYYAGGRKIAEFNDGGARPGETVTHQVNFGTLTGKQKVLAVWNIADTANAFYACVDVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP66</accession>
    <name>A0A7K2ZP66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamylcyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001551">
        <property type="protein sequence ID" value="MYW34161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015610940.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001551.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="145" mass="16200" checksum="A249FBD58198EF99" modified="2021-04-07" version="1">MSLYAAYAGNLDARLMTRRAPHSPMRSTGWLNGWRLTFGGEQMGWEGALATVVEAPRSQVFVALYDLAPMDEDSMDRWEGVGLDIYRRMRVRVHTLDGEEPAWMYVLNGYEGGLPSARYLGEIADAAESAGAPHDYVMGLRKRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPL0</accession>
    <name>A0A7K2ZPL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_34235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001559">
        <property type="protein sequence ID" value="MYW34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="282"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="404" mass="42032" checksum="52BE16560E865510" modified="2021-04-07" version="1">MSTEAFVYDAIRTPRGRGKANGALHGTKPIDLVVGLIHEIQGRFPDLDPAAIDDIVLGVVSPLGDQGSDIARIAAIAAGLPDSVAGVQENRFCASGLEAVNLAAAKVRSGWEDLVLAGGVESMSRVPMGSDGGAWAMDPMTSFETGFAPQGIGADLIATIEGFSRRDVDEYAALSQERAAAAWKDGRFDRSVVPVKDRNGLLVLDHDEHMRPGTTADSLAGLKPSFAAIGDMGGFDAVALQKYHWVEKIDHVHHAGNSSGIVDGAALVAIGSKEVGERYGLTPRARIVSAAVSGSEPTIMLTGPAPATRKALAKAGLTIDDIDLVEINEAFAGVVLRFVKDMGLSLDKVNVNGGAIALGHPLGATGAMILGTVIDELERRDQRFGLVTLCVGGGMGVATIVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPM1</accession>
    <name>A0A7K2ZPM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Insulinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_34865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001592">
        <property type="protein sequence ID" value="MYW34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="199"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="459" mass="49398" checksum="BB84642741AB1F4F" modified="2021-04-07" version="1">MTSRSSATTARPSSEGRAVARTQTLLKGTGGIGTVRRTVLPGGLRIVTETLPSVRSATFGIWANVGSRDETPTLNGATHYLEHLLFKGTAQRTALDISSAIDAVGGEMNAFTAKEYTCYYARVLDTDLPLAIDVVCDMLTGSLIAPEDVDAERGVILEEIAMTEDDPGDCVHDLFAHTMLGDTPLGRPVLGTVDTINALNRGQIARFYKKHYDPTHLVVAAAGNVDHATVVRQVRKAFEKAGALSRTDAVPMAPREGSRTLRTAGKVELLNRKTEQAHVVLGMPGLARTDDRRWALGVLNTALGGGMSSRLFQEVREKRGLAYSVYSYTSGFADCGLFGVYAGCRPSQVHDVLKICRDELDRVATHGLDDDEITRAIGQLSGSTVLGLEDTGALMNRIGKSELCWGEQMSVDDMLARIAEVTPDDVREVAGALLTHRPSLSVIGPLKDKQADRLHEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPX0</accession>
    <name>A0A7K2ZPX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_35105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001603">
        <property type="protein sequence ID" value="MYW34367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="11160" checksum="E852FCB3363D580F" modified="2021-04-07" version="1">TESSRPPRPGGWRPTLRDDLEDVAARAGLKPDGSGRVSCPFGYADPDSAVRGLLSTGLFDAAVRATDRSQVEKEVAEALHPYRRPDGTVWMPNVFRYLVCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ36</accession>
    <name>A0A7K2ZQ36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001625">
        <property type="protein sequence ID" value="MYW34460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="9970" checksum="B0FA7028E98B1EF6" modified="2021-04-07" version="1">MASTLAGPRAGIADDMTEDDNGRGFERDETDSVFRQLVGQLHLVGGRTADTESGPAAGGFFRPTANTLQCDQCGGWFGFTPGNLWTCGACIAIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQC6</accession>
    <name>A0A7K2ZQC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpmE</name>
        <name evidence="8" type="ORF">GT040_35800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001629">
        <property type="protein sequence ID" value="MYW34498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="74" mass="8031" checksum="6E13C6D1CA96289F" modified="2021-04-07" version="1">MKRDIHPEYVETQVSCTCGASFTTRSTIDNGAIRADVCSECHPFYTGKQKILDTGGRVARFEARFGKAAGSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQG7</accession>
    <name>A0A7K2ZQG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001643">
        <property type="protein sequence ID" value="MYW34583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="11599" checksum="D37D546546472E4B" modified="2021-04-07" version="1">MRTLGPSSRTRLVAAGYVGLVTLAALAYEIAGQPEAGEAAMTLAAWPGAIVLLVMIYPLAVLLGDDPLLGETVFNLLGPLLHGAGALVNVLIVWGVIAFARHFKAEYSQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQJ9</accession>
    <name>A0A7K2ZQJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001636">
        <property type="protein sequence ID" value="MYW34539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="336"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="430" mass="45869" checksum="45084E3D9DBED2E4" modified="2021-04-07" version="1">MTSSPRRFPYVPGTAAPVTAEQRWEQFYRYGPYAVLTLATLVGAVAADLIMTRTEMYAAGALAVAAYGLQIWWGRARPRTAPGAPAGVAYYSVRTLLAFALSWLNPFFAIYAALSYFDVEPLLPKRFVRAGLLTTAVTLAGSQSGGLPPASLMNWVAFAVLYVVNATLALFFWQVGLREEEKARVQAATIAELERTNLRLEAAMAENAALHAQLLVQAREAGVDDERRRLAAEIHDTLAQGLTGIIAQLQVVTSTRDSAPDTARVHLEKAAALARHSLGEARRSVHNLAPAALEHDELTGALEKTVATWAEQHRVRADFTVTGTAEPVHDEVAATLLRIAGEALANAGRHAGASRVGVTLSFMDDELTLDVRDDGRGFDPGAAAPASRTGGFGLGGMRARAERIAGTVEVESEPGGGTAVSARVPLVRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQM5</accession>
    <name>A0A7K2ZQM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">trmB</name>
        <name evidence="3" type="ORF">GT040_36410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001653">
        <property type="protein sequence ID" value="MYW34617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="237" mass="26077" checksum="F4B02D65A024BA99" modified="2021-04-07" version="1">RFPGGPAADPAGSHHERRIRSFQPRRSRVTTGQQDALERLWPKWGLDIDGKRVLDLDQLFDGLPVVLEIGFGMGEATARMAADDPGTGILAVDVHTPGQGNLLGLADKAGSTNVRVANGDAVILLREMLAPESLDGLRVYFPDPWPKARHHKRRLIQPEFLDLVAPVLKPGAIIHCATDWEPYAEQMLEVLTAHPRFENTAADGGYAPRPAFRPLTRFEGQGLDKGHVVHDLLFARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQY5</accession>
    <name>A0A7K2ZQY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="8" type="ORF">GT040_36880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001680">
        <property type="protein sequence ID" value="MYW34707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="7">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="20599" checksum="CF5BF9456B3E565B" modified="2021-04-07" version="1">MAEIKLATEVRTEFGKGAARRIRRANQVPAVVYGHGAESVHITLPGHELLLALRTANVLIGLEIDGKDALVIPKAVQRHPLKGTIEHVDLLTVKRGEKVNVEIAVHAEGDLAPGANLLEFVQNTLLVEAEATHIPESVTVSVEGLDAGDSIVAKDITLPKGATLAGDEDAIVIQVVAAQAEEPSADEAAAEAEGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR57</accession>
    <name>A0A7K2ZR57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">GT040_37000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="17508" checksum="BDF4C1D459CFAF15" modified="2021-04-07" version="1">MASETPGAVPAATPAAPVIPLVGIGTDIHAFEEGRELWCAGLKWEGEGPGLAGHSDADVVAHAACNALFSAAGLGDLGQHFGTGRPEWSGAAGVTLLTEAARIVRAEGYEIGNIAVQVVGVRPKIGKRRDEAQKVLSAAVGAPVSLSAATSDGLGFTGRGEGLAGIATALVYRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRI4</accession>
    <name>A0A7K2ZRI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001737">
        <property type="protein sequence ID" value="MYW34991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="12125" checksum="259BB2EC1AC35CAC" modified="2021-04-07" version="1">GLDPVESLVSHTATGKGMAIRWILSSRGWRRTDWEAASGRLRERGLLAAGEELALTDAGTALRAEVEEATDRMDRAPYEHLGAEGVERLTELGRGFLFTAAANGAFPAEATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRS2</accession>
    <name>A0A7K2ZRS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4 C(11)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cobM</name>
        <name evidence="8" type="ORF">GT040_38400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001739">
        <property type="protein sequence ID" value="MYW34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="249" mass="26205" checksum="F1183E41437B85CC" modified="2021-04-07" version="1">MTVYFIGAGPGAADLITVRGARLLAASPVCLYAGSLVPVELLAECPPDARLVDTANLDIEQITEELVRAHADGHDVARLHSGDPSVFSAVNEQMKRLDDAGIPYEVVPGVPAFAAAAAALKRELTVPTVGQTVILTRIAQRATAMPEGEDLATLGRSGALIILHLAARYVDRVVEELTPHYGADCPAAVVAMASRPDEIILRGPLDSIAEQVKAAGVIRTAVIMVGRTLGAEQFRDSHLYAVGRDRGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRU2</accession>
    <name>A0A7K2ZRU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_38915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001772">
        <property type="protein sequence ID" value="MYW35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="406"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="612" mass="66773" checksum="33E0EE79234FBD09" modified="2021-04-07" version="1">MSDLILGVSAFYHDSAAALIADGVPVAAAQEERFTRRRHDPSFPARAVAYCLDEQGVSLDDVSAVAYYEDPRLKFRRVLATFAGAAPTGFASFRDTLPAWLGPGGKLRTADTVRAELAALGRGRVPDLSVRRHHESHAVSAFFPSPYESAAVLCIDGVGEWATTTLWHGRGTDLRPVSELRFPHSLGLLYSAFTYFCGFKVDSGEYKLMGLAPYGKPRYADLIREKLIDLKPDGSFRLDMRYFAYLRGQVMTGRGFEKLFGGPRRTSETPLTEREFDLAASVQAVTEEAVLRLARTARERTGESRLCMAGGVALNCVANGKVIDAGIFDEVWVQPAAGDAGGALGAAQAVAMERGARRDHVRTGHDAMSGSLLGPAYGDEEIAAYLDARSIPYRRLDSDTLAAQVADGLAQGKIVGWFQGRMEFGPRALGARSIIGDPRNPDMQSAMNLKIKFRESFRPFAPAVLAEDAKDYFDLPQESPYMLVVSQVAAAQRLEAQDGGASGLDLLKVRRSTIPAVTHVDHSARVQTVTGHSNPAYHRLLTAFKALTGCPVLVNTSFNVRGEPIVNSPQEAYTCFMRTDIDMLALGNFLLEKSDQPAWQEASDWRDEIPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS08</accession>
    <name>A0A7K2ZS08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_39115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001777">
        <property type="protein sequence ID" value="MYW35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="349" mass="36661" checksum="2BEBBEBF21EEBFD9" modified="2021-04-07" version="1">MTAEVEPPVRPTLEDVAAVAGVSRATVSRVINGATTVDPALRTVVEEAVATTGYVPNRAARSLVTRRTDSVALVISERERRPDSEPFAGRMFSDPYFGRVVSGLLEVLRPAGIQMVLMLADDAASRTQLLSYLRHGHVDGVVLVTSHADDPLPHLLQETRLPAVLAGRPPLPSSLAYVEVDQQAGARLAADHLAALGRRRIGTISGPQDRPAGHIRLAGFLDALAAHGIEDVACAEGDFTLLGGAAAMRRLLAEQPGLDGVFIASDLMALGALPVLQRAGRDVPSDVAVVGFDDSSAAAACDPPLTTVRQPVEEMAAEMARLLLKQIGGPGGPSPSMVFPPTLVRRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS31</accession>
    <name>A0A7K2ZS31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_38620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001757">
        <property type="protein sequence ID" value="MYW35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="10"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="406" mass="42971" checksum="3F1F38E922FD1C08" modified="2021-04-07" version="1">MQVSQLTQHRIIVIGAGYAGAIAAGRLARRLRREDVAITLVNPEPDFVERVRMHQLAVGQELRPRPFAEMFAGTGVRLRLARVTAVDVDRRTVTVTATDATAGEDLTYDTLVYALGSAWNTHDVPGTAEHAHDIAGRPGALRLRERLAALGAGQPVVVVGGGLTGLEAATEIAETRPDLDVALAAHAALGDWLSPKGRHHLRRVCDRLGITVHEHTTVTAVAADHVTTAADDIPSSVTVWTTGFAVHPIAQATALKTDATGRIEVDGTMRSVSHPDVYAIGDAALVMGPNDKPLRMSCASGIPTAWQAADSIASRLTGTKPTTVPLRYFNQCISLGRKDGLIQYVTADDQARPAALTGKTAALYKELVCKGAAWGVANPTLAKPTRRRGVMQGPTPLPHPTTANAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSH9</accession>
    <name>A0A7K2ZSH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="19044" checksum="056EE4EB808C1FF9" modified="2021-04-07" version="1">MPLTFELDPAFSPALRDGITALWADVSNAGGAVGFVPPVTAEEIRPELLKHLVAIEEGRTRLLVGRDEDGAVAATAFLTLNTHRLMTHWLWLYTVMVHPRHQGQGYGRDLMAATAGAARSIEGIEAIRLTCRGGTGADRFYAACGYKEVGRVPGGIRVAPGDDRDDIVMLLPLGPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z688</accession>
    <name>A0A7K2Z688_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000035">
        <property type="protein sequence ID" value="MYW27860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="262" mass="27764" checksum="3F5F0C776FEF5DFF" modified="2021-04-07" version="1">ELLRTVLRYAGGLPEARLAALRPLVRRLVDELTRQLATRLRPALTGTMLARPTRRPGGQLDLSRTLRANLATARRTADGTVQVVPEKPVFRSRARRSADWRLILVTDVSGSMEASTIWSALTASVLAGVPTLSTHFLAFSTEVVDLTGHVHDPLSLLLEVSVGGGTHIAAGLRHARSLITVPSRTLVVVISDFEEGAPLGGLLSEVRALVATGCHVLGCASLDDAGRPRYSTGVAGQLVAAGMPVAALSPLELARWIGEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6C8</accession>
    <name>A0A7K2Z6C8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mltG</name>
        <name evidence="9" type="ORF">GT040_01055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000053">
        <property type="protein sequence ID" value="MYW27895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW27895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="583" mass="64592" checksum="8C0745D37DE051E4" modified="2021-04-07" version="1">MTEYGRGPGSEPWHPEDPLYGDQGWGGRQAAHGQSQYGDQQQSYPQDPYAQQHQSQNHQQYPQQQSYDQHQQYDPQQPHQQQYQHQHQYGAQQQDPYGQQPPAQPQYDGGWDSGQHAAVPYGAEPQDPYAQQQPGYGESHDYYGTPEAYPPPQPPGRREAPEQQRKPSTDWDPDEPQEETHPFFTGADEPAAREPRDDDDDPDDDSSRSSRRDRGGSERRGGKGKKKSRNGCACLVVSLVLVGGLGGVSYVGYTYWKKQFGAPADFAGAGTSEQVEVEIPEGSFGYDIANILRKKGVIKSSDAFVAAQNDNPKGKSLQAGVYLLNKEMSAASAIELMLDPKSQNALVIPEGTRNVTVYAKIDDRLGLKKGTTAEIAKTKAESLGLPGWANDNPDLKDPLEGFLYPAAYPVAKGSKPEDALKRMVVRANKEYDKLDLEAAAKKHKLDGPWQVITVASLVQVEGKTHDDFRKMAEVVYNRLKPTNTETNQLLQFDSAFNYLNNQSNIKISESEILSNKDPYNTYTQKGLTPGPISNPGADALAAALNPTTEGWLYFVATDGQHKTEFAKTYDEHLKLKEKFDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6J7</accession>
    <name>A0A7K2Z6J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_01295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000058">
        <property type="protein sequence ID" value="MYW27942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026242237.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000058.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="18226" checksum="B779C141E0214F46" modified="2021-04-07" version="1">MADSVALDPVDLHILRLLQNDARTTYRELAAEVGVAPSTCLDRVTRLRRSGVILGDQLRLDPAKLGRGLQALLLVQVRPHRRELIGPFVDRIRALPESRALFHLTGPDDYLVQVAVADAADLQRLVLDEFTSRREVARVDTRLIFQQWECGPLLPPEQPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6R1</accession>
    <name>A0A7K2Z6R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_01650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000069">
        <property type="protein sequence ID" value="MYW28008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="382" mass="41141" checksum="C2B3D6B2149C6B8E" modified="2021-04-07" version="1">MPGWLPRAMVLALALYACFQLGSWAFDQVIGLLTNVLIAFFLALAIEPAVGRMSARGMRRGLATFLVFIGLMIFSAGFVVLLGSMLAGQIVDMVDDFPEYIDSVINWVNQTFNTELSRVQVQDSLLHSDWLQKYVQNSATGVLDVSTTVLGGLFRLLTIFLFSFYFAADGPRLRRALCSVLPPARQTEVLRAWEIAVDKTGGYIYSRGLMALVSGVAHYILLVVLGVPYAPALAVWVGLVSQFIPTIGTYLAGALPMLIAFTVNPWYALWVLGFVVVYQQFENYVLQPKLTARTVDIHPAVAFGSVVAGTALLGAVGALIAIPAVATLQAFLGAYVKRYDVTDDPRVHGGHRPRRGGPALSRIRRALGGSGRTGGGGAGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6V5</accession>
    <name>A0A7K2Z6V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000090">
        <property type="protein sequence ID" value="MYW28074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="237" mass="25754" checksum="B7FACC39130121A5" modified="2021-04-07" version="1" fragment="single">MTGTRITALGLNRSTLARQLLLRREPLDAAEGVRRVVALQAQQPASPYVALWNRLTAFDPAGLDTAFTDHRVVKATLMRLTLHAVHADDHPAFREAMHPVVRASRLGSRFTASGLTVADADALVPRLLEFADRPRTTAECEAWLGEQLGAPPQDGAWWGLRQYTPLLHAPTAPPWSFGHRPSYIAPRTGPVRTDPEASAASLRTLVLRYLSGFGPASVADVAQFAMVTRARARAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z715</accession>
    <name>A0A7K2Z715_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNHCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000104">
        <property type="protein sequence ID" value="MYW28140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024439">
        <property type="entry name" value="RNHCP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12647">
        <property type="entry name" value="RNHCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNHCP" evidence="2">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="140" mass="14798" checksum="BEDDBB42E11BCF1F" modified="2021-04-07" version="1">MTRRGARSGGARRPQRPKDVLHGPVGARGDAFRCVGCRLDVSLVAPGTAHRNHCPSCLVSLHVDRRVPGDRAAGCGGRMTALSMSVRADGEWMLIHLCLTCGELSANRIAGDDNALALIRLALRPLADAAIPASRVMLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z760</accession>
    <name>A0A7K2Z760_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000111">
        <property type="protein sequence ID" value="MYW28190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="27407" checksum="51E93ECDC8A87B76" modified="2021-04-07" version="1">MTSLARHHLSPAETGPALRALGEWTSASVPGGGLHPGDVGWFLRFHDAAVLLWTDGGIPVAVGFLDGPVLRVTAAPVADLGALAADAEEVLVSGNAWSDGLPIPGWEPDQKESWLVLSWAPRPVSSRAETVVGGAMTSDRVLVHRAAFAGSTFTVERHRTMMRSPAGGLAVETLVRTPAGEPAAAATGWFAGEGRCGLLEPVGTHPDHRGHGYGRDAVLGACAALVHRGASAVAVATPAANEAAVALYRSAGFTVASENRDWVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7K5</accession>
    <name>A0A7K2Z7K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_03090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000144">
        <property type="protein sequence ID" value="MYW28285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="65"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="113"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="320" mass="33731" checksum="226A7BE2417E86ED" modified="2021-04-07" version="1">MTETTAGATRADVWLPFPAEEIDGLPDAFDYLFWDGGPEYPGDPADCVYYVVPYLKGSEVAVRPMDAMSAVQVVQTLSAGIDHVEPGLGLLHPGVRLCNAKGVHEASTAELTLALILASLRGLPGFVHGQGKEEWRSGFYPALADKSVLIVGYGSIGAAIEDRLAPFECARVARVARSPRTTERGPVHTLDDLPALLPEADVVVLSTPLNPSTRGLVDADFLAAMPDGALLVNVARGGVVDTKALLAELESGRLRAALDVTDPEPLPSGHPLWHAPNVLITPHVGGSTSAFEPRAKRLLATQLTRFAAGEPLANVVSTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7R4</accession>
    <name>A0A7K2Z7R4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_03695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000154">
        <property type="protein sequence ID" value="MYW28397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="284"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="351"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="637" mass="68347" checksum="3016EA2257C6886D" modified="2021-04-07" version="1" fragment="single">MAEGSAAPNPGEPGVRAERAAGPGRKASRMSRFLQGGRLFQDRTPGGPVPRLLMRWVRRPLLPAVRLWRRNLQLRVVAGTLLMSIGVVLLLGFVVIGQVRNGLLDAKGKAAQTQAAGGFAAAQEKANASLAPGGQGTEGPDGMTANTSWRTELVDQLASGGKNAFNVVALSADSVGEGAGSRAPRGSGSVEAASVPERLRQDVGKGQGAFQTYSLIRYSNGNESQPGLVVGKRLYDIDQQAYELYYLFPLTQEEKSLTLVKTTLATAGLFVVVLLGAIAWFVVRQVVTPVRMAAGIAERLSAGKLQERMKVTGEDDIARLGEAFNKMAQNLQLKIQQLEELSRMQRRFVSDVSHELRTPLTTVRMAADVIHEARADFDPVTARSAELLGDQLDRFESLLSDLLEISRFDAGAAALEAEPIDLRTVVHRVIGGAEPLAERKGSRILVIGDDQPVIAEADARRVERVLRNLVVNAVEHGEGRDVIVRMGVAQGAVAVAVRDYGVGLKPGEATRVFNRFWRADPARARTTGGTGLGLSIAVEDARLHGGWLQAWGEPGGGSQFRLTLPRTADEPLRGSPIPLEPEDSRRNRESRERDEASAGDNRLVSVPNQPGAAKRSPLPVPARPSTVPHPAPASVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z835</accession>
    <name>A0A7K2Z835_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_04245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000194">
        <property type="protein sequence ID" value="MYW28501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:alkyl sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="5">
        <location>
            <begin position="84"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="606" mass="66171" checksum="93AFB8AC4BCB848D" modified="2021-04-07" version="1">MSDLDYADRSDFEDADRGFVAALSPAVVRTDEGRVIWDGEAYAFLDEDCPETAHPSLWRQSQLCNKQGLFEVTTGIYQVRNLDLSNMTLVEGDTGVIVIDPLISAETAAAALALYREHRGDRPVTGLIYTHSHGDHFGGSRGILPHGHAPVPVIAPAGFLEHAVAENVYAGGAMTRRAVYMYGAELEKGPAGHISAGLGITTSKGTITLVPPTVDITRTGQEETVDGVRIVFQMTPDTEAPSEMNFYFPDRRALCMAENATHNMHNILTLRGAVVRDTRIWAHHLNETIALFGDQAEVAFASHHWPTWGHDRIVDHLAGQRDMWAYLHDQTLRMTNQGLTGAEIAERMELPPAVARRWANRGYYGSVSHNVKAIYQRYMGWFDGNPAHLWEHPPVEQARRFAADYGGVPALVAKGQEYAASGDLRFAATLLGHAVFAAPEDTAARHALAAVYEKLGHGAENGPWRNFYLMGAQELRGTVAHTALETTNPEMAMALTVDMLIDSLAIRVDGPRAWDEKLTMTWNVTDEDRTWHLLLSNGALTYRSTDAPTAGAPAADLALTLTKPQLLGVLAGRGLDGVHVEGDPQVLATFVGLLDTPDPDFPIVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z868</accession>
    <name>A0A7K2Z868_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000198">
        <property type="protein sequence ID" value="MYW28531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="30224" checksum="342DE0D19C1ED42F" modified="2021-04-07" version="1">MDLNTVLDVRDGRSPVPWRPGDAWLGGGTYLFSEPQPQLRRLVDLSRMGWEPVRELPDGSLELAATCTIAQLSRFGKAWRAPAAPLVEQCCRAFLASFKIWNMATVGGNLCNALPAGPMISLTAALDGTCLLRAQGGSLRRVKVADFVTGAGRRDLAEGELLRSVTLPARALASRTAFRQASLYGLGRSGALVIGVLDPVDGSLAVTVSAATVRPFRFWFPLPPDRRTLHDTIDSTIGAGDWFDDIHGLPAWRRHMALRFAEEIRRELTSGTEASGETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8D4</accession>
    <name>A0A7K2Z8D4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000206">
        <property type="protein sequence ID" value="MYW28583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="376" mass="40041" checksum="0F7DB0A89FE4CECD" modified="2021-04-07" version="1">MKSAKEKNSFLRGPKYLQVAERLRREIADGAWAPGTQLPVEKELAGTLAISVNTLRRAVSELVDEGIVQRRQGAGTFVSPPGEANAGEGEQPRGRRLVGVLVPSTTYYYPRVVDGIQRVLREAGVGVLLASSKYDPALEREEVRAMVDSGVQGLLLVPNLHLLDDAQAHVDALHRLPVPHVLVERFPPAPAPDDPTTYVGTDHPGGVCLALRHLSSLGHRRIGHLGRLRTGTADIVARGFDEAAALLGVEVVDGSVARQDHWTDEGITAYVRHCADAGITAVFCHGDRDAAALVVAARRHGLSVPGAFAVVAYDDEVAEVGDLPLTAVSPPKEEVGALAAQLLLSRMESGPGAVSHQIRIQPRLVVRASCGAAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Q0</accession>
    <name>A0A7K2Z8Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000246">
        <property type="protein sequence ID" value="MYW28702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="556" mass="61489" checksum="33DD65CF9F382E52" modified="2021-04-07" version="1">MANDVFDFSPGAQIPIQGSGGQSVATNALASAAYRDSPVDVILDANSDWHKSTVKPGASKLFKSDYFKPNLGEAFSRAVQERMLGGSRAALIQSFGTDPQTVVEHCLSANNLRKARDTRLTLITVVFGFLFLPGMIAWVIAFRIKDALAKSKDAAFRAVGTVLLAAFGIGALILLWKLPTDRFWPLYVRGAIVAPLIGWFLAKRIAETSAQDLRARWGGLLSGTGVIAKIPEAVPKNPNETAREALRQGLEKLSAEQQSNAVFYAGPKGILGMGTRWGSWQLAEELTPKDSTKEIHQFRSWDLIRIIHDQLKMLERGPLNTGGFPKPSVKHWIVSPIGENADSVSRPDGEDVATFQVKPHEIQRICNHQQFGSGDRHYLGVQFTLWDGQLVITMMITVTVLHETLRIEVTGHALGPVHGLFFAKPANRTKTVNKTVRFWETRDIQLPVVEAREVVRLALRAPFTWYPPVLDYLGGKIVLPEPFGLRHAWAAKPWNHRFMADDAMRAATPVLRVVHSAAMRVLAENGVDTERFDNRSMILSGLVQDPSPRKADVYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8Y1</accession>
    <name>A0A7K2Z8Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_05855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000256">
        <property type="protein sequence ID" value="MYW28807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029908883" evidence="5">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="31375" checksum="7456D38C25D3BBA7" modified="2021-04-07" version="1">MNARTVRPRLRRLPLNIAAAVTVVVCLFPVYWMISTAFKPSKDIQSADPQLFPHTWTLTHFQRAVEADGFALFWRNSILVTLGAVLLALLVALGAAFAVARMRWKGRRQFMLMVFIAQMAPWESLIIPIYIISRDTDMLDRLPTLTLIYFMITLPFTIVVLRGFIGTIPPELEEAAQVDGCTRTGAFWRVAMPLLAPGLMATSLFGFITAWNEFAYANFLIIKQQDNRTLPVWLSSFQNTFGTDWGATMAASTLFALPALVIFLLLQRHVTSGFAAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9C9</accession>
    <name>A0A7K2Z9C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000302">
        <property type="protein sequence ID" value="MYW28964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="23387" checksum="46853C8F5CE3472E" modified="2021-04-07" version="1">MSRFNQLAQTTTVRQVQQEMGSATAAGRRLREQVEEPDPLDARSADFIRNLDGFLFASVGETGWPYIQFKGGPQGFVHVLDPYTLAFLDVRGNRQYVTTGNVRGDDRVALFFIDHARQARLKVFGHATAVPVDENLALAERLESPRTEGRVEQIMTVRVEAYAWNCPNHITPRFSQQEVSEALAPLHERLARLEEENAALRAELAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9J2</accession>
    <name>A0A7K2Z9J2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="11">RNAP omega subunit</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoZ</name>
        <name evidence="12" type="ORF">GT040_07010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="WWKE01000314">
        <property type="protein sequence ID" value="MYW29030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015607348.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000314.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW29030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="90" mass="9779" checksum="A81FF08A60B249CD" modified="2021-04-07" version="1">MSSSITTPEGIINPPIDELLEATDSKYSLVIYAAKRARQINAYYSQLGEGLLEYVGPLVDTHVHEKPLSIALREINAGLLTSEPIEGPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9S8</accession>
    <name>A0A7K2Z9S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000347">
        <property type="protein sequence ID" value="MYW29110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="125" mass="12853" checksum="D203AEB3E83302EF" modified="2021-04-07" version="1" fragment="single">GSVDLLLIATADGSEPGLALLAEQAYRRGCTVVAVAPTRSPLREAVDGVHGLVVPMAAAPHGEYDAETSAAGPGTLWALLTPLLALLDRVGLVTAPAEELQRVADRLDRTAERCGPAIATYSNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9V8</accession>
    <name>A0A7K2Z9V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/LC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030567158.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000356.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15046" checksum="29D5CD30802057E4" modified="2021-04-07" version="1">MTATTDEKLNWLLEGLLDRTPGTRHALVLSRDGLKLCRTPELSVDQADQLAAISAGIQSLSHGASIEFGDGTGGVRSAMAEFYGGVLFIVEAGAGAHLAVVADEDSDVGLVGHNMSELVEQLGEHLVAPPRSPAADIPSAAESSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA44</accession>
    <name>A0A7K2ZA44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Squalene--hopene cyclase</fullName>
            <ecNumber evidence="6">5.4.99.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">shc</name>
        <name evidence="6" type="ORF">GT040_07965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.17" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000366">
        <property type="protein sequence ID" value="MYW29216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051007">
        <property type="term" value="F:squalene-hopene cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SQHop_cyclase_N" evidence="5">
        <location>
            <begin position="41"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="4">
        <location>
            <begin position="336"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="666" mass="73221" checksum="24AD7BD5888B7E64" modified="2021-04-07" version="1">MTATTDGSTGAANLSAAPAGHPADTTTAADDVLAAARQAAERSVAHLLGRQDEQGWWKGDLATNVTMDAEDLLLRQFLGIQDPETTRAAALFIRGEQLGDGTWNTFYGGPGDLSATIEAYVALRLAGDRPEEPHMARASAWIREQGGIAAARVFTRIWLALFGWWKWDDLPELPPELMFFPKWVPLNIYDFGCWARQTIVPLTIVSAKRPVRPAPFALDELHTDPAEPNPARKLAPAASWDGLFQRLDKGLHLYHKVAPRLLRRIAMNVAARWIVERQENDGCWGGIQPPAVYSIIALHLLGYDLDHPVMKAGLASLDRFAVHREDGARMVEACQSPVWDTCLATIALVDGGLRPDHPALVKAADWMLAEEITRPGDWSVRKPELAPGGWAFEFHNDNYPDIDDTAEVVLALRRVRHPDPARLEAAIERGVRWNLGMQSRNGAWGAFDADNTSPFPNRLPFCDFGEVIDPPSADVTGHVVEMLAVEGLGGHPRTRRGIEWLLAEQEACGAWFGRWGVNYVYGTGSVVPALVAAGLPAAHPSIRRAVTWLESVQNDDGGWGEDLRSYTEEKWIGHGESTASQTAWALLALLAAGRRDSRAVARGVTWLTEAQQADGSWDEPYFTGTGFPWDFSINYHLYRQVFPLTALGRYVYGDPFADRAGVAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAB5</accession>
    <name>A0A7K2ZAB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000399">
        <property type="protein sequence ID" value="MYW29321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7586" checksum="555CE1CAA6D55086" modified="2021-04-07" version="1">FCRVVLASARLGLGELEQACRLGAEAAQQASEMRSVRAAEYVRAFERSLEPYRDAAPVRGYRDRVAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAS8</accession>
    <name>A0A7K2ZAS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_09160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000417">
        <property type="protein sequence ID" value="MYW29439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="145"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="252"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="406" mass="43778" checksum="392826F2FF68C231" modified="2021-04-07" version="1">MSSTDSAKPSKLPPFDAADPLGIDDLLGRDDLAIRDTVRTWAADRVLPHIAEWYEKGELPGIRELARELGGLGALGMSLDGYGCAGASAVQYGLACLELEAADSGIRSLVSVQGSLAMYAIHRFGSEEQKQRWLPGMAAGEIIGCFGLTEPDHGSDPAGMRTYAKRDGEDWVLTGRKMWITNGSVAGVAIVWAQTDEGDEGRGIRGFVVPTDTPGFSAPEIHHKWSLRASVTSELVMDGVRLPTDAALPDAKGLRGPLSCLSHARYGIVWGAMGAARASFESALDYARTREQFGRPIGGFQLTQAKLADMAVELHKGILLAHHLGRRMDAGRLRPEQVSFGKLNNVREAIEICRTSRTILGANGISLEYPVMRHATNLESVLTYEGTVEMHQLVLGKALTGLDAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAV4</accession>
    <name>A0A7K2ZAV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000420">
        <property type="protein sequence ID" value="MYW29463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="12193" checksum="513ED7DBC3D24739" modified="2021-04-07" version="1">MKYMLLIHSGAVDEQGGAPQCTVEDWMAYDKDVRDAGILVSGESLADLVTATTVRVSPAGERTVTDGPFAETRELLGGFLVIDVPDLDAALDWAARCPGARDGGSVVVRPVADFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB04</accession>
    <name>A0A7K2ZB04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000427">
        <property type="protein sequence ID" value="MYW29492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="19882" checksum="1F8F8403AB13B65A" modified="2021-04-07" version="1" fragment="single">MMTKVGFLPEETSSFVGRRAELARLETALATRRMTTLIGPGGVGKTRLAVRAARAAADRYPDGAWWADLSPLYDDALLLPTVSDAVGLADHTLRMPVEALCEWLSDKRLLLVLDSAEHLRAPCSHLLAELLTTSPGLTVLVTSRQPLGTRGEHAVRIQPLPVDGAPDALQLFEDRLRAGDPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB26</accession>
    <name>A0A7K2ZB26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000443">
        <property type="protein sequence ID" value="MYW29512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="12494" checksum="82BC6E751C89AFCB" modified="2021-04-07" version="1" fragment="single">LVHAAAGGVGSAAVQLGKAAGATVIGVVGGPDKAAVARELGCDLVIDRRGEDIVAAVKEATGGRGADVVYDPVGGDAYAKSVKCIAFEGRVLVVGFAGGSIPAPALNHALVKNYSIVGLHWGLYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBY9</accession>
    <name>A0A7K2ZBY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
            <ecNumber evidence="3">2.7.1.148</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000520">
        <property type="protein sequence ID" value="MYW29880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029682200" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="2">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="7448" checksum="954FAE2D4AC864DC" modified="2021-04-07" version="1">LQPAALSLRPSLAATLAAGAEAGALAALVSGSGPTTAFLVADESAARKVADALLASGTCRNARVAPAPAPGAHVVTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBZ2</accession>
    <name>A0A7K2ZBZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000505">
        <property type="protein sequence ID" value="MYW29828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8319" checksum="6264E97B71A19846" modified="2021-04-07" version="1">LGPRYCPGAAASEILTPVALASLVRSRTLRTTTPGRTVRVSLELTPMPKGLTMVATPREPHPPAPGPAQGERADPARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCK5</accession>
    <name>A0A7K2ZCK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000594">
        <property type="protein sequence ID" value="MYW30086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18481" checksum="7DE2FFDA74F557F0" modified="2021-04-07" version="1" fragment="single">DLRFAFLAELAEAVLPHIEAYADVVEPAERNETDPATGKKTKVEVELCTDAPQLIVPSRAGIEFVRLLGRSMRFRRTAEDDPETPYPAPARVPLLGRWLTHYGERARVPGSSLLLTATDLLNRHWATGQSSLEDQHLGALLAWIDPPGGASGAEAALAAELGRDHDGQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDB2</accession>
    <name>A0A7K2ZDB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000654">
        <property type="protein sequence ID" value="MYW30334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="13017" checksum="9686BD577ACF9378" modified="2021-04-07" version="1">MVHIGTVVMGASDVRRAAAFWKAAFTYTEREPGTDDWVVLVPVEGPGVGVALGRSASPVQEVPRVHLDLYSDEQQAEVERLVGLGAERVAWELYPPDPDFVVLADPEGNRFCVIDTTHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDC9</accession>
    <name>A0A7K2ZDC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_13940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000657">
        <property type="protein sequence ID" value="MYW30361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="107"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="542"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="659" mass="72246" checksum="1B6A4AE3FDA0368A" modified="2021-04-07" version="1">MTAATPDAPLWQPSPERIEAAAVTRFQSWAASRFGAPAEGGYAALHRWSTDELDTFWQAVAEWFDIRFSTPYESVLGDRTMPGATWFPGATLNYAEHALRTAEDPARADTPALLYVDETHTQVPISWSDLRRQVGALAAELRAIGVTPGDRVSGYLPNIPQAVVAFLATATVGGVWTSCAPDFGARSVLDRFQQIEPVVLFTVDGYRYGGKEHDRTETVAELRRELPTLRAVVHIPLLGTDAPEGALAWAALTSADTEPVFEQVPFDHPLWVLYSSGTTGLPKAIVQSQGGILLEHFKQLGLHCDLGPEDRFFWYTSTGWMMWNFLVSGLLTGTTVVLYDGSPGFPDVSAQWRIAEQTGATLYGTSAAYVMACRKAGIHPGRDFDLSRVQCVATTGSPLPPDGFRWLHDEVAEDLWIASVSGGTDVCSCFAGAVPTLPVHIGELQAPCLGTDLQSWDPSGKPLTNEVGELVVTNPLPSMPIRFWNDPDGSRYHDSYFDTYPGVWRHGDWITVTDRGSVIIHGRSDSTLNRQGVRMGSADIYEAVERLPEIRESLVIGIEEPDGGYWMPLFVHLAEGATLDDDLRAAIKATIRENLSPRHVPDEVIEVPAIPHTLTGKRIEVPVKRLLQGTELAKAVNPGSVDNLDLLHFYAELAANRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDI7</accession>
    <name>A0A7K2ZDI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000664">
        <property type="protein sequence ID" value="MYW30396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006123591.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000664.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="8340" checksum="570D03AF8C203E28" modified="2021-04-07" version="1">MARCEVCGNDYGMSFEVHAQGAVHVFDCFSCAIHRMAPICEHCRVQVIGQGVEADGHWYCGAHCARAEGKAGIVDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDN6</accession>
    <name>A0A7K2ZDN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000682">
        <property type="protein sequence ID" value="MYW30477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="75"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="244" mass="26788" checksum="0999C08EE4E86D99" modified="2021-04-07" version="1">KTETDRAVSLTAEQAGLYEAVVRETLAEIAGADGFERRGLVMKLLTALKQICNHPAQYLKEDRPRIADRSGKVELLDELLDTILAEQGSVLVFTQYVQMARLLEEHLAERGVRTQFLHGGTPVARREEMVGRFQAGEAPVFLLSLKAAGTGLNLTRAGHVVHFDRWWNPAVEAQATDRAYRIGQTQPVQVHRLIAEGTIEDRIAEMLARKQGLADAVLGSGEAALTELTDAELADLVELRGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDR5</accession>
    <name>A0A7K2ZDR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hrcA</name>
        <name evidence="7" type="ORF">GT040_14680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000690">
        <property type="protein sequence ID" value="MYW30493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511542.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000690.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="103"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="338" mass="36849" checksum="E322960DB47C0C30" modified="2021-04-07" version="1">MLSERRLEVLRAIVQDYVGTEEPVGSKALTERHQLGVSPATVRNDMAVLEDEGFIAQPHTSAGRIPTDKGYRLFVDKLAGVKPLSSPERRAIQNFLDGAVDLDDVVGRTVRLLAQLTRQVAVVQYPSLTRSTVRHVELLSLAPARLMLVLITDTGRVEQRMIDCPAPFSEASLADLRARLNSRVVGRRFADVPRLVRELPESFDSEDRGTVSTVLSTLLETLVEETEERLMIGGTSNLTRFGHDFPVMIRPVLEALEEQVVLLKLLGEATDSAMTVRIGHENAHEGLTSTSVVAVGYGSGDEAVAKLGVVGPTRMDYPGTMGAVRAVARYVGQILAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDU0</accession>
    <name>A0A7K2ZDU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000690">
        <property type="protein sequence ID" value="MYW30492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="25382" checksum="F955BEDD0F2D1EBA" modified="2021-04-07" version="1">MDVLWEDFGWERLGHGIGRRRLPGWDATAALVAGADGVLLYDTGSTLREGVELRGQAEALLGRRVTHIALSHPHFDHVLGTAAFAGAQVYGAVGITALLKRSADELTGSAVHHGLAEDEAHRAVDTLVVPHHEVTGEWTLDLGGGRQVLLANVGPGHSGHDLAVLVPGTDGEPPVVLCGDLVEESGEPQAGRDAIPSRWPAALDRLLELGGEGAAYVPGHGAVVDAAFVREQRAALAERFGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE17</accession>
    <name>A0A7K2ZE17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000715">
        <property type="protein sequence ID" value="MYW30559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="24377" checksum="ED0769F0CB8A9124" modified="2021-04-07" version="1">MPAVLNPVLDLLTLRGTVTEAEQLTARIRRLRIESGQLAGLEVQPGQQVRVLVGGLTLRTYSIWHYDQSGVVELCVLDHAAGGPGARWGHTVAPGEQVRLRRPEGTFTLRPDAAHHLFVGDETASVAFGAMLAALPGDAAVSGCIETATATDRLPLPGGDRLDWVLRGETSLPDAVRRLAPTPGGIAYIAGEARDVQAVRQVLREAGWDRRAVLTKPFWTPGKKGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE67</accession>
    <name>A0A7K2ZE67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar isomerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000721">
        <property type="protein sequence ID" value="MYW30622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="36"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="25915" checksum="3DB4A833C8C16947" modified="2021-04-07" version="1">MSDSKLAGQFFDAAIGLLQRVRDEEAGSIAAAGAAIADTVEAGGRLFAYGAGHSSLAAQDVVYRAGGLALMNLLTVPGTTGVDVMPATLGSALERVDGLASAVLDSSPATAGDVLVIISLSGRNALPVEMAQNARALGLKVIGVTSVAYAENTRSRHTSGGFLRDHCDIVLDSKIAIGDAELSAPGIEAPFAPASTVVTSAIMQSMMAAAAEHLVARGIEPPLLRSGNVDGGHDWNGRVMTEYRERIFYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE91</accession>
    <name>A0A7K2ZE91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxynitrite isomerase</fullName>
            <ecNumber evidence="1">5.99.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ferric nitrobindin</fullName>
            <shortName evidence="1">Nb(III)</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="1">Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.99.-.-" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000725">
        <property type="protein sequence ID" value="MYW30646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062213">
        <property type="term" value="F:peroxynitrite isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="3">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="1">
        <location>
            <begin position="34"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="19747" checksum="FB5E7F23BA2749DE" modified="2021-04-07" version="1">MSDPAPRHPYPDAFRPDETPAPHPLLTPVLGLLGTWAGSGRGGYPTLDDEFAYAQEITFSHDGRPFLHYTSRAWLVEAEGHPLRPSARESGWWRLQPEGRVEALITQPTGIAEIAVGLAGDGTVDLATHEVALAPTAKQVDATRRRYTLTGGDTLSLVHDLAAVGQPLQHHLAAEFRRCSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZED3</accession>
    <name>A0A7K2ZED3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_15835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000735">
        <property type="protein sequence ID" value="MYW30710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="73" mass="7586" checksum="E42BC913D96A9CDB" modified="2021-04-07" version="1">AAHPGALAEAMEGFGVAEAAERAGVPVLELRAVSNTVGPRDRAAWRIGDALAALTEAFGKSAPVLEGWNRHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZES6</accession>
    <name>A0A7K2ZES6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000760">
        <property type="protein sequence ID" value="MYW30785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="83"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="285" mass="30944" checksum="E135F59E87F18860" modified="2021-04-07" version="1">LAGEYDGHPSPDRATELAALFPYGEFTVQRCAGHFPWLDDPGAFSRTVAAFLDPDVLTVQAGGVRLAYRVWSRTPPEPSAPPVVLLHGRAGSSLTWTPIAEELAAEHRVYAPDFRGHGLSDWPGRYSFELFRDDLHAFLEARDLAGATVIGHSMGGVAAYLLAQREPGLIGRLVIEDAPPLLPLDPPRPQAERPEGELDFDWPVVPDIDAQLNDPDPASRERLAEITAPTLIIGGGATSHIDQEQLADMARTIPDATFTTIEAGHLVHTTRPEEFLAALRSFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF02</accession>
    <name>A0A7K2ZF02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000791">
        <property type="protein sequence ID" value="MYW30912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="47"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="307" mass="31986" checksum="FF7C85505DA88E61" modified="2021-04-07" version="1" fragment="single">GTGSGDYPDGVLRVGLTEPGGERVPTERTAAEILDLLGLPVPPGADQDELAEMVREALAVRRLVLLLDDAADAEQVDPLLPENPDCLVVAVATGPLTGIPDVRPCTLGGLEAGAAVQLLARAIGQVRITVDPRTAESLSEECGGQPAALALIGGWLAAHPMASVADVTKQLHELPDTGDQQPTGARPLARAFRLVHDSLPQAAARILRLLALAPAGLADAHTASALAGCSVSAAEKTLDDFVKLGLLRTDGAAHPQYGVPGCLAPMLRALLEDRDRPAEIQLARARMLERTVRRLQACRAVTEAEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFC9</accession>
    <name>A0A7K2ZFC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000828">
        <property type="protein sequence ID" value="MYW31060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="34" mass="3518" checksum="699704ED5AF9665E" modified="2021-04-07" version="1" fragment="single">MHPADRHPAPAAHRRRTAVTTLAVTAATALLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFE5</accession>
    <name>A0A7K2ZFE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000847">
        <property type="protein sequence ID" value="MYW31097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="109" mass="11987" checksum="FD5C0AB4E95D5DC5" modified="2021-04-07" version="1" fragment="single">AGRITRRSADAAGGPAGPGAYSEFGPWFWRRLRLPEEERIDLLRRLVPADGVPRTDGDERYLDAVARRLTLNAPVVLPLLCRWFTDERPLLIGGPDAPDEGLRPTVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG44</accession>
    <name>A0A7K2ZG44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000897">
        <property type="protein sequence ID" value="MYW31333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="269" mass="28481" checksum="B8E922749F640FCA" modified="2021-04-07" version="1" fragment="single">MLRRGWWPRWTNIIGQEEPRRNQASDLSGPPDRPCVHDPGVTTPPQELIEAALARADAGLLARHLDARTCAPELLGRPVRHPDPRVRHLGLGLALLTERTSAPAVAACSDSAASSESGSGSGSDSGSGSGSGQQELLVSPLPDSSGATPEESPALAELHGRLRPEPDRPRRPLPDWRAAGWPVRVQIAWLRAELLADPAVVSMEPAGELLYQAVRATDVLDAHHPERLVAGLAATGDPVLQDEALRLARAGLHAGLLAPAVVRGLLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG93</accession>
    <name>A0A7K2ZG93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_19420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000909">
        <property type="protein sequence ID" value="MYW31383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="296" mass="31081" checksum="6A0CC1F3FF0C2BE6" modified="2021-04-07" version="1">MSASTAAPTRTRATSKAPAPTARARRRSAAVGLAAWAVGIVFCLPALWMVLTSFHSEADAATNPPSLAAALTLDGYRTFFGGGGGPTPWPPLVNSLTASLFSTLLVLLLALPAAYALSIRRVRKWTDVMFFFLSTKMLPVVAGLLPIYLFAKNTGLLDNIWLLVLLYTSMNLPIAVWMMQSFLADVPVSIIEAAQVDGAKLPTVLGRVVAPVAAPGIAATALICFIFSWNELLFARVLTGVVAGTAPVHLTTFVTSQGLFLAQLCAASVVVSLPVLIAGYAAQDKLVQGLSLGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGG2</accession>
    <name>A0A7K2ZGG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000920">
        <property type="protein sequence ID" value="MYW31444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="PTHR11510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="187" mass="19146" checksum="99CEDAB3BAA9085C" modified="2021-04-07" version="1" fragment="single">MADSPGRRTGVWFIGARGSVATTATAGCAAIAAGLHPPTGMVTETPPFADTGLPPLTSLVFGGHDTLDCPLAKRAEALAEGGVLPYRLPTAVRAELDAADAEIRPGGPLPGETRTDQELIAAFAADLTDFAHRNELTRTVVINVSSTEPAPAPDDPRLPASSLYAAAALRAGCSYANFTPSTGLRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGL1</accession>
    <name>A0A7K2ZGL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DO-GTPase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000934">
        <property type="protein sequence ID" value="MYW31503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045528">
        <property type="entry name" value="DO-GTPase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19993">
        <property type="entry name" value="DO-GTPase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DO-GTPase2" evidence="1">
        <location>
            <begin position="109"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="421" mass="45693" checksum="DB10E3F44A0ADEAE" modified="2021-04-07" version="1">MTTVICPYCFDRAPAARLPYRCLMMATGVRGGTPCDAEPDDVWADFMGPSLPPSRRLRGPVFPAPRTLSSLRGASARQPCPGCGVATSVRVCRGCHNDFPSEYCDQDSRIIALVGAKASGKSTYVSVLVNELRGRVGREYNISLPAMGTETQRRDREMEEDLYERLRLPDTTRPAAMGFNDPLLYRLSVPRRGRYAKGSRHTTLVFFDAAGEDLKSAEAMARYTQYLAAADGIILLVDPLQMGSVRDRSASADGPPLPAVETSPQQIASDLAAQLRSHGRSVSRGRVTTPMAVAVTKTDALRALLGSHSPLLRNATHTGGELDDDDRLAVHEELRSLLSDWDSGVICRQLENDFAELSYFGLSALGAPPPADAPADAPKSGPQPLRVEDPLLWLLGRRGLVPVRKSRPEGQKKNRTGKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGM4</accession>
    <name>A0A7K2ZGM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000930">
        <property type="protein sequence ID" value="MYW31490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="81" mass="8138" checksum="26F98E644421B56F" modified="2021-04-07" version="1" fragment="single">MGSHSAQPPIPTPTTPAGREGLEAILARPDRAVIALDFDGTLADIVPDPERARAHPGAVEALAALAPKVASVAVITGRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGM8</accession>
    <name>A0A7K2ZGM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_19700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000918">
        <property type="protein sequence ID" value="MYW31439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="351" mass="37678" checksum="A96F07C9E26B1D9E" modified="2021-04-07" version="1" fragment="single">MLVAGRYRLISPIGRGGMGEVWRAADEVLGRAVAVKLLLGDQADASSTARFRLEAQTAARLSHPHLVAVFDFGAWEDRFFLVMELVEGQSLGDLLAAQERVHPEQVARIAGEAAAGLAAAHRQGIVHRDIKPGNLMLDADGSVKIGDFGIAQFVDDPSTALTTAGHIVGTSLYLAPERALGRTADSASDMYSLGCVVYQLLLGQPPFKSDTATATLYQHVDTPPVPLRQRGVDISAAFDSYLLGLLAKKPEERPTAQQVSDWFRTDAWRGRPEPLPMPKPTSRRAAPSPAPSPSAPAAPAGPATYRLPQPTGRRRSTTSRSVPARRRSTREAIRRRPRVASAIAGTATFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGP6</accession>
    <name>A0A7K2ZGP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000946">
        <property type="protein sequence ID" value="MYW31533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ada_Zn_binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="130" mass="14372" checksum="74CE7933E3B078A2" modified="2021-04-07" version="1" fragment="single">MHTDTERCVRAVQSKDARFDGWFFTAVLTTRIYCRPSCPVVPPKVRNMTFYPSAAACQQAGFRACKRCRPDTSPGSPEWNARADSVARAMRLIRDGVVDREGVPGLAARLGYSARQIERQLLAELGAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH73</accession>
    <name>A0A7K2ZH73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cellulase family glycosylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_20930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000984">
        <property type="protein sequence ID" value="MYW31675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029690715" evidence="3">
        <location>
            <begin position="28"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="76"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="482" mass="53481" checksum="A86345BE78464D74" modified="2021-04-07" version="1">MRMGRALIALVVASVLAAGALAPAASAHPASTRAAAPSTYGHAVPPLTDSRGRALTLRGWNVEDKANRGEAALSAITERHFRDLRAGGFNFARLLVFWDDLEPRRGQYSERYLRKIERILGWARQHRIQVLIDAHQDVFGPAFGHRGIPEWATRTDGLPFTPNPDDWFSEYFQPAVQRAFTHLYEDPDLRRAQAAMWQVLAERFRGHPAVIGYDLINEPMGELREGEDLPTAARRIEAQHLTPMYNRLARAIRAKDRTTWLFVEPTPIVGEGVPTGLGRIHDSRTVYAPHFYNTAMEAGADYDPSAGWIEAYEAAVTAYPARHRMPVVVGEWGPLNNSLPNMGRFYREAVASLNRYSSGWAGYVWCYGGGYCAVDERGRFRTNKEQTATPYAPAVAGTVRSDTYDATARSYRLAYRAATRPGFTELSLPPSSRGWRVSVTGRAARVLGKAPYGGRLAVVAWPGAEVVVTVREAGPYGRTDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHC5</accession>
    <name>A0A7K2ZHC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_21300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001013">
        <property type="protein sequence ID" value="MYW31744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="409" mass="43465" checksum="AF135733DDA90918" modified="2021-04-07" version="1" fragment="single">MSKLPGWLGRFGSELTELGSRLEERRARAHGDDDPLGASDTADPGQVPAPPTYAPTVAAKPDPVAAIPWGMRVAAEAGWRLLVLAGTLWVLMQVITAVELVVLAFSAALLITAMLQPTVVRLKRYGLPHGLATAVTAVLGFVIIGLVGWFVVWQVMENLDTLSDRVRDGIDELKRWLLDSPFHVTESQINDIAKNLNDTIGTNTEEITSAGLQGVTFMVEFLTGLLLAMFSTLFLLYDGRRIWEWTLKLVPAAARPGVAGAGPRAWRTLTAYVRGTVLVALIDAIFIGLGLYVLNVPLAVPLAVFIFLFAFIPLVGAVVSGALAVVVALVTEGVWTALWALVVVLAVQQIEGHILQPFILGRAVRVHPLAVVLAVATGGLVAGIGGAVVAVPLVAVTNTVVGYLRSYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHD5</accession>
    <name>A0A7K2ZHD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001014">
        <property type="protein sequence ID" value="MYW31747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="469" mass="50852" checksum="8739F0690DDA11AA" modified="2021-04-07" version="1">MDPSPGATPYSAPAGCPMSQQQTSLYGPEFAADPHRAYDAFRAHGPAAPIELAPGVNATLIVQHEAALRVLQNPALFARDSRRWAALREGAVPMDSPVLPMMMYRPNCLFTDGAEHLRLRKAVTESLARLNSSRLSRDVERIADYLIDQFIERGTADLLNEYAKLLPLLLFNQLFGCPGDIGDRLTRSMSAIFDGEDVLRANGELTECLMELVALKRRQPGEDITSWLIQHPAGLRDEELKDQLVMLMGAGVEPERNLIANALLLMLAGDQPGGPERRGSGMLVEDALDDVLWNNPPIANYATHYPVRDIELDGVVLKAETPVLISFAAANSDPSLTDARQTLSKGAHLAWGAGPHVCPAKSPATLIALTAIEKILNTVPDLSLAVPASGVGWRPGPFHRALISLPVRFTPTAARRIATGTQPPAPTSAQLPDPYRNAPPQQASAGRHAAEPAKRPKGWWSSFLDVFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHH1</accession>
    <name>A0A7K2ZHH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="14063" checksum="EE38BC9431F615A5" modified="2021-04-07" version="1">MSTTATAVAPLTIQDAEALVAAARSAAEAAGVAVAVSVVDAGGHLLAFRRDDRAVLIAGETSTRKAFTALQLDAPTADLVDAVQPGGLFHTLPTALERPLLFIAGGVPLRRDGRLIGAVGVGGGAPEQDHGFASAAADSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHQ6</accession>
    <name>A0A7K2ZHQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001029">
        <property type="protein sequence ID" value="MYW31855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029803889" evidence="1">
        <location>
            <begin position="34"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="78"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="517" mass="56941" checksum="DAA01D828798B6C8" modified="2021-04-07" version="1">MRSVRVRILAIFAVLVIAGVGAWQLLPSGEAKADAITVGTSDVVSSLDPAGAYDAGSWAIYSNIYQSLMTFKPGAIVPEPDAAESCAFVGQKLQTYQCKLRDDLVFSNGRKVTAEDVKYSFDRIFTIKSDVGPAGLFPTLDTVSTEGRTITFNLSGKDATFPQKLATGAAAIVDPTKYPKDELRKGNQVDGSGPYVLKSYEPDNRAELVPNLKYKGALKKIGEAVSIRYFKASEDLATAWNNGDVDIAHRQLPASKLAELDEGDPELRVTEAASAEIRNIIFNTRESSPFGEKKVRQAVAALLDRGPLVSKVYQGTVEPLYSLIPTGYIGHSTPFFDAYPTSDPERAKKLLEEAGVETPVPVNFAYREGDMYTKETAELRRQLQKDGLFKVSVKAVEWTKYQKGYAAGEYDMYTVGWFPDFPDPDTFSQPLVGTGNVLHSGYSSKKMDRLIAATQQFSDRGRTSNDFKEMQKLVGEDVPLLPLWQKKDYVVAKTAVAGSQYLSDGTGFWRLWELSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI84</accession>
    <name>A0A7K2ZI84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001072">
        <property type="protein sequence ID" value="MYW32044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="195" mass="20740" checksum="19C4F605C1A9C20A" modified="2021-04-07" version="1">MTVLRSLTAADAPAVRRVYGGVAATFLGRSAMTAQEAEEYVARVRGWAGADPVEQYVLGVDVAGDLVGIVKLAHRPDGHGRVSYALREKRWGRGYATRAVEELVTFAFTTVGLDSLGARHHPGNPASGRVLEKAGFTRVGMVNGMIEYRLLEAVPGARLAESLGDTLRIAASRGGRLESEGCVVSGVRRPRRGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIL7</accession>
    <name>A0A7K2ZIL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParB N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="15690" checksum="B7DC934495A43F8E" modified="2021-04-07" version="1">MTARVVDGKPWTGRMRTAALRRGLVRPAEFSTWIGARRYHERHGRDRQVLEKLRASIPRDGIREPLLLGVRATDRLVFVFEGHHRAVIALELGVRSFPFQWFWDPDVKVVEHEPFPHHALGPDGQDWLCHQEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIW7</accession>
    <name>A0A7K2ZIW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2510 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001134">
        <property type="protein sequence ID" value="MYW32292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="3">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="302" mass="30195" checksum="053EA729A6B4E175" modified="2021-04-07" version="1">MTPPGWHPDPGHSGKGPDQERWWDGAQWTGHVRPSPAAVRRRGIRIGVGAIVGAVVLAAIGGGMYLLREDDGGRPGIAVASPSTPPPAPEGSGAPDGGNGSEGDKDGEDGGGSQGPGEQLPPTEPGYATDLAAGISLPVPKGWTGKSAAVGAGLTTGEHTCPGGADKTCVRGGVFSAPAVALKLTAGTAEEAAKKDIAVNAEESYGGDSYGKITSHEEIRSGAVTVAGQKGYAVRWKVVTEKGDDGYVESLVFSSPASKDMLVVVRSGFDINKDAPKLSVLDQIVKGIKAASGAGAGNGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ06</accession>
    <name>A0A7K2ZJ06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_24395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001148">
        <property type="protein sequence ID" value="MYW32322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="31"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="329"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="551" mass="57493" checksum="7CA68E25C2CCF735" modified="2021-04-07" version="1">MTHAGQTAEGSVAALFRVALLRDGRGLRIGLTTVAFMVHQLCEALVPVLIGVVIDRAMAPADRAALVWWLAALGGVFVVLSLSYQRASSSMVTVYGYGEHELRRRAMTRLLDPLSLRRRPGSGEALSLVSSDTYRVAGVSWSVVQQASTLTAILTASVALLVISVPLGVGVIAGTVLILVVMRRVSMPLEARGLAEQGSAARASEVATDLITGIRVVAGMNARAEAARRYRTASDTSRRGAVAASRSVLAYSGLSQLLSGAFLAALATASGYLALDGHISIGQLVTVLGLAQFLQGALAHVGTFASNWIHKRASARRLGELIDAPPLIVPPANGTVAEPGPSLLRWHPPGHGEPLDLLPGDLVGVVPHHPAHARGLSDRLGYRVPLPRGELLIGGVDAVDLGPDRVRARVLAPPHHGAVFSGTLHANLVPRGSAVDPAVTAAAMLDDVRQQIGGDLAEVGEYGRRLSGGQRQRLLLARALHADADLVVLDEPATAVDPVTEQRIAEGLRSLPSTILLITASPILLSACDRVVEPGAADDASHDPNGSPGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJC4</accession>
    <name>A0A7K2ZJC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_24980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001169">
        <property type="protein sequence ID" value="MYW32434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="326" mass="35553" checksum="143D02CE21A004FF" modified="2021-04-07" version="1" fragment="single">MSADRTTDDDIEDLLRRHAPQVLGALVRRYGHFDPAEDAVQEALIAAAAQWPEDGVPENPRGWLIRVASRRLTDRLRSDEARRRREETVAALTPADAFVAPPPGEGPAGLGGRAPSEDDTLTLLFLCCHPALTPAAQIALTLRAVGGLTTAEIARAHLVEEATMAQRISRAKRAVRGAEFRRPEPEDRDRRLAAVLQVLYLIFNEGYTATAGPDLHRTDLAREAIRLTRSVRRLLPHEGRVTGLLALMVLTEARTPARTGPDGELIPLDEQDRALWDRTAIAEGTALAEEALTQGPAGDYQLQAAIAALHDEAGRAEDTDWPQILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJS4</accession>
    <name>A0A7K2ZJS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_25745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001200">
        <property type="protein sequence ID" value="MYW32581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PTHR45779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="123" mass="12895" checksum="AE768826B50519D1" modified="2021-04-07" version="1">MSIEKPEIDFPGGEPPADLEIKDIWEGDGPVAKAGDQVKVHYVGVAFSTGEEFDASWNRGTPLAFNLGAGQVIAGWDQGVQGMKVGGRRQLTIPAHLAYGDRGAGSAIAPGETLIFVCDLVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJX7</accession>
    <name>A0A7K2ZJX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_26080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001211">
        <property type="protein sequence ID" value="MYW32647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="261"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="283"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="621" mass="65629" checksum="D7CD26A46E7E3D90" modified="2021-04-07" version="1">RRPAAQPAMNRTMDAVDVAAAAAAALDGAVLNGISPSPVVADLTQGVSVERDRDRTGSTPVPGAREAGQHGGAGTDRASAGKDRGDTGKAGASASGPVDPGGVPDLTKPAPERTGDLPARAEQLQLSGDITYSLPSLDLLERGGPGKTRSAANDAVVASLTNVFTEFKVDAVVTGFTRGPTVTRYEIELGPAVKVEKITALAKNIAYAVASPDVRIISPIPGKSAVGIEIPNSDREMVNLGDVLRLADAAEDDHPMLVALGKNVEGGYEMANLAKMPHVLVAGATGSGKSSCINCLITSIMVRATPEDVRMVLVDPKRVELTAYEGIPHLITPIITNPKKAAEALQWVVREMDLRYDDLAAFGYRHIDDFNHAVRTGKCKTPEGSERELSPYPYLLVIVDELADLMMVAPRDVEDSIVRITQLARAAGIHLVLATQRPSVDVVTGLIKANVPSRLAFATSSLADSRVILDQPGAEKLIGKGDGLFLPMGANKPTRMQGAFVTEDEVAAVVQHCKDQMAPVFRDDVVVGTKQKKEIDEDIGDDLDLLCQAAELVVSTQFGSTSMLQRKLRVGFAKAGRLMDLMESRNIVGPSEGSKARDVMVKPDELDGVLAVIRGESAPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK80</accession>
    <name>A0A7K2ZK80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">GT040_26605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948630.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001248.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZK80"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="61" mass="6949" checksum="BCAD093782CDB444" modified="2021-04-07" version="1">MAKKALIAKAARKPKFGVRGYTRCQRCGRPHSVYRKFGLCRVCLREMAHRGELPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK97</accession>
    <name>A0A7K2ZK97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_26745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001250">
        <property type="protein sequence ID" value="MYW32772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948568.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001250.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7K2ZK97"/>
    <dbReference type="GeneID" id="63982204"/>
    <dbReference type="GeneID" id="67394167"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21955" checksum="F3835464B689CC60" modified="2021-04-07" version="1">MTSVLVCDDSPLAREALRRAVATVPGVERVTTAANGEEVLRRWGADRSDLILMDVRMPGLGGVETVRRLLSADPGARIIMLTVAEDLDGVALAVAAGARGYLHKDASRAELRATVTQALADPTWRLAPRRLRSAEMGAAPTLTAREIQVLEGMSHGRSNAEIGRELFLSEDTVKTHARRLFKKLGASDRAHAVALGFRWGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKH0</accession>
    <name>A0A7K2ZKH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001264">
        <property type="protein sequence ID" value="MYW32854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="439"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="530" mass="56597" checksum="2E79B651E03D3E58" modified="2021-04-07" version="1">MVFRSEYADVPALDVPIHEAVLGEAAGFGDTVALIDGTNGMSLTYAQLDGFHRRIAAALAEAGLRKGDVLALHSPNTIAYPAVFYGATRAGASVTTVHPLATAEEFAKQLADSGAKWIVTVSPLLETARRAAELTGGVQEIYVCDQAPASEGHTSILDMLSSTAPEPAVVIDPGEDVAALPYSSGTTGTPKGVMLTHRSIGTNLEQLRPFIPMGEGDRILAVLPFFHIYGLTALMNAPLRCGSTVVVLPRFDLAQFLEAIQTHRITGLYVAPPIVLALAKHPLVGEYDLSSLRYIVSAAAPLDAELAEACSTRLGLPPVRQAYGMTELSPGTHVVPLSVEQPPPGTVGKLLPNTEMRIVSLEDPAQDAEPGTDGEILIRGPQVMKGYLGRPDATADMIDADGWVHTGDVGRTDEDGWLYVVDRVKELIKYKGYQVAPAELEALLLTHEQVADAAVIGVYDAEGNEVPKAFLVRGPAAEGLTEDDVMAYVAERVSPYKKVRQAEFIGAVPRAASGKILRRELRDREKAEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKJ3</accession>
    <name>A0A7K2ZKJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">nadA</name>
        <name evidence="10" type="ORF">GT040_27140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="WWKE01001263">
        <property type="protein sequence ID" value="MYW32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="392" mass="42955" checksum="25D0B3437E22E715" modified="2021-04-07" version="1">MTTAQPLDVQPTPLALLLLGREADPRSERGVECPGDLPSPSDPDLVARARAAKEKLGDRVFVLGHHYQRDEVIQFADVTGDSFKLARDAAARPEAEYIVFCGVHFMAESADILTTDAQAVVLPDLAAGCSMADMATAEQVAECWDVLTEAGVADQVVPVSYMNSSADIKAFTGKHGGTICTSSNAKRALEWAFEQGEKILFLPDQHLGRNTAVRDMGMSLEDCVLYNPHKPNGGLTAEQLRDAKMILWRGHCSVHGRFSVESVEDVRARMPGVNVLVHPECKHEVVAAADYVGSTEYIIKALEAAPRGSKWAIGTELNLVRRLANRFASEDKEIVFLDKTVCFCSTMNRIDLPHLVWTLESLADGKLVNRIEVDPETEKYAKLALERMLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKK6</accession>
    <name>A0A7K2ZKK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-CoA:diacylglycerol acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.122</ecNumber>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_27310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:23472"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:18195"/>
            <dbReference type="ChEBI" id="CHEBI:18234"/>
            <dbReference type="EC" id="2.3.1.122"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mycobacterial A85 antigen family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="4"/>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001270">
        <property type="protein sequence ID" value="MYW32882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029695141" description="Acyl-CoA:diacylglycerol acyltransferase" evidence="7">
        <location>
            <begin position="37"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="330" mass="35666" checksum="DE920B433767F11C" modified="2021-04-07" version="1">MLSTDHPTRRGVMKAAAGLTAMTTLGAGGVLASASAAHAVGDGFGLRVVDRGEADARMRYYRFATSAIGWNPGVNVLLPDGYHTSGRRYPVLYLFHGGGTGQDFITFDRMGIRAWTAGKPLIVVMPDGGAAGWYSNPVGSNVGPRNWETFHIAQLLPWIDANFRTYAEYDGRAVSGFSMGGFGALKYAAKYYGHFASVSAHSGPASLRRDGGLVTHWANLSSAAVELGGATVYGAPLWDEARVSADNPVQRVESYRNKRVFLVAGTSPDPVNWFDTVNETQVLAGQREFRGRLGAANIPHEWHEVPGGHFVRPDLFRRDLDGIVARLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKM3</accession>
    <name>A0A7K2ZKM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001270">
        <property type="protein sequence ID" value="MYW32883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="7435" checksum="722019DBE2B8B7A5" modified="2021-04-07" version="1">DAPLAVAVAQAYCSGVAVHAAEECVQLHGGIGMTWEHPAHLYLKRAKADSIAYGSAGSHREAVAELAELPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKM7</accession>
    <name>A0A7K2ZKM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001278">
        <property type="protein sequence ID" value="MYW32902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="419"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="511" mass="54057" checksum="A675B02FBBFC104A" modified="2021-04-07" version="1">MVSLLDAIRDHAARTPEATALRAPGRIVSYRQLDTWIDRLARLLTAHGVGPERVCALALEPGPESVVAVAAVLRAQGAFLTLDVTQPPPRLAAMVRSGGATVLITRSALRERTGLTVDGPVIDLDDAAEPDGPGGSGPPGATPAGSGRQLAYVSHTSGSTGTPNAVLIERAGLDSYLGFIARDYGLGPDTVALQVAPLGYDASIRDTFAPLVAGGTVVLAERGTLLRADSFAETVRREGVNTLLSVTPSFLTFLAQQDPAGEHLRGLRLVVTSGESLLPFLRSGARRLLPGSLVNQYGPTECTMTATRYVVPPEPDTTRDLVGTPIDGMTVRLTGPGGDEVPPGGTGEIILGGIGVARGYLGRPRLTADRFRPDPGGPPGARAYRTGDLARAGEDGVLEYLGRSDRQVKIRGYRVDPAEIEGVLLGHPRVTGAVVTAEPDERGRVFLYAHVTGPLDEVTDAELRRHLATALPPHMMPRRFHRIERLPTTRTGKTDRAALRRTAAPVPDRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLP7</accession>
    <name>A0A7K2ZLP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">GT040_29435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001362">
        <property type="protein sequence ID" value="MYW33275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003965959.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001362.1"/>
    </dbReference>
    <dbReference type="GeneID" id="63983087"/>
    <dbReference type="GeneID" id="66958253"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8717" checksum="B4E52F3B2EAF6A8A" modified="2021-04-07" version="1">MLEEALEHLVKGIVDNPDDVQVAERTLRRGRVLEVRVHPDDLGKVIGRNGRTARALRTVVGAIGGRGIRVDLVDVDQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLQ5</accession>
    <name>A0A7K2ZLQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001364">
        <property type="protein sequence ID" value="MYW33285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="34568" checksum="FD4373050D05FE54" modified="2021-04-07" version="1">MPKAPDEQPPGTKILAAAAAAALLAGGGALVLSLRGGDEPAPQTSFCWGSLTREDVSGLIVVPRERYTSRETAVATPRLSYCDVDDEFTLSLESLHSAESVWETAEEVAAASPVRAPIPGAPGWVNRSYAGVLLPTDCADALAKPAPYLQIQATNDQEDTWRDGALQQRMATVLTTASDRLTGKLGCSGPAPATPPGNAPPVLEREELDPARACGIEGFAPLKPSAVAGFSQAATGGDFRLWSCAIGAGDDDSDNLVHFTVTQEAALVERHGADDKDRSALLTCAGRPTLVQVGHFYGLKEKPARDDLRPDADLLTGLADAVAGQAGCERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM08</accession>
    <name>A0A7K2ZM08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001388">
        <property type="protein sequence ID" value="MYW33391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="87"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="439" mass="46861" checksum="022B0ABAF5150479" modified="2021-04-07" version="1">RPVPQEQARAALPLEEGVQDGWVSIEDGLVRATVDVRPYGGPDGEDWFIVSDLGCAVGGAGGIGSHEEGVVLGVGGASTTLASITVRTPVASALDLGTGSGIQALHAAQHATRVTATDLNPRALEFTRLTLALSGAAPADLREGSLFEPVGTETFDLIVSNPPFVISPGARLTYRDGGMGGDDLCRTLVQQAGSHLNEGGRAQFLANWQHVEGEEWQDRLRSWVPAGCDAWIVQREVQDVTQYAELWLRDSGDHRSDPAAYAERYEAWLDEFEARGTTSVGFGWITLRRSAAAAAGNPSVVVEEWPHTVQQPLGRAVEEHFARQDYLREQDDAALLAGHFTLAAEVVQEQVGVPGAEDPEHVVLRQHRGMMRATKVDAVAAGFAGVCDGSLPAGRILDAIAQLMSEDPVLLRDRTPQAIRLLVEEGFLEPVPVPGAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM53</accession>
    <name>A0A7K2ZM53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplL</name>
        <name evidence="7" type="ORF">GT040_29820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010058811.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001382.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="127" mass="13299" checksum="2A73F5BFDC5866FF" modified="2021-04-07" version="1">MAKLSQDDLLAQFEEMTLIELSEFVKAFEEKFDVTAAAAVAVAGPAGPGAVAEAAEEQDEFDVILTGAGEKKIQVIKVVRELTSLGLKEAKDLVDGTPKPVLEKVAKEAAEKAAESLKAAGASVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM58</accession>
    <name>A0A7K2ZM58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="5 16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GT040_30350</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 16"/>
    <dbReference type="EMBL" id="WWKE01001396">
        <property type="protein sequence ID" value="MYW33454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="17">
        <location>
            <begin position="7"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="18">
        <location>
            <begin position="454"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MYW33454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="584" mass="64575" checksum="FC84E7934F3EC1F6" modified="2021-04-07" version="1">MQIHKYDTVIVGAGGAGMRAAIESTKRSRTAVLTKLYPTRSHTGAAQGGMAAALANVEEDNWEWHTFDTIKGGDYLVDQDAAEILAKEAIDAVLDLEKMGLPFGRTPEGKIDQRRFGGHTRSHGEAPVRRACYSGDRTGHMILQTLYQNCVKEGVEFFNEFYVLDQLITEVDGVKKSAGVVAFELATGEIHVFQAKSVIYASGGTGKFFKVTSNAHTLTGDGQAACYRRGLPLEDMEFFQFHPTGIWRMGILLTEGARGEGGILRNKDGERFMEKYAPVMKDLASRDVVSRSIYTEIREGRGCGPAGDHVYLDLTHLPPEQLDAKLPDITEFARTYLGIEPYTDPIPIQPTAHYAMGGIPTNVEGEVLADNTTVVPGLYAAGEVACVSVHGANRLGTNSLLDINVFGKRSGIAAAEYAVKNDFVELPENPAQLVADQVERLRNSTGTERVAELRTELQECMDANVMVFRTEQTIKTAVAKIAELRERYRDVSIQDKGKRFNTDLLEAIELGNLLDLAEVMAVSALARKESRGGHYREDYPNRDDVNFMRHTMAYREVAADGAESIRLDYKPVVTTRYQPMERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMK4</accession>
    <name>A0A7K2ZMK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sirohydrochlorin chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_30875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001433">
        <property type="protein sequence ID" value="MYW33550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="19197" checksum="296F353BC7F6B390" modified="2021-04-07" version="1" fragment="single">MPLDSTAQLLTRVTAQLATQLSLVSRNGTRRPMHRTRPSDTPRLPAAPRPSPAEAAPPTLLVVAHGSRDPQALRTVLALLDRVRDLRPGLDVRLGHIELNQPLLPDTLDGLRGADAVLVPLLLGRGHHVKHDLPAAAAAAPSVRTRIAAPLGPHPLLVEALYGRLVEAGWDPADEEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMN3</accession>
    <name>A0A7K2ZMN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="9665" checksum="CC2E9446A3012801" modified="2021-04-07" version="1">MATPNPNGCRHDGIDQRTHARQWTPDAGWHAWEKPTQEQIKDRMRARRSARTERIRHSGPDTKFCVLCLSGEHQRNDATDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN47</accession>
    <name>A0A7K2ZN47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001464">
        <property type="protein sequence ID" value="MYW33781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="34581" checksum="6765235D4D987BAB" modified="2021-04-07" version="1" fragment="single">MPVPVPQQRGVPAAETPHGADLTVLVIEDDPAGSITGPELSAAAGTRVRIRTARNLTEAGRLLTDDVDCILLDLALPAPTTTATATTTTPGHRPEPAPGRADELAVLTHVLRIAPLHAVLVLTAQDDTELAAEAVRVGAQDYLFRGELDARVLSRAIRYAVERKRADLAQHQLTESGLRAQENARLERGLLPTPLLEGSDLSFAARYRPGRSRALLGGDFYDTVRTPDGTVHAMIGDVCGHGPDEAALGVELRIAWRALTLAGLCGDQLLSTLQQVLEHERQSEEIFATLCTVDIAPDGRRAGLCLAGHPAPLLARRGRPARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN69</accession>
    <name>A0A7K2ZN69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001480">
        <property type="protein sequence ID" value="MYW33801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029854373" evidence="1">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="6847" checksum="D8E64E852B479B7D" modified="2021-04-07" version="1" fragment="single">VAVTALACALAAGAGLSPARVALVGMAVLTGQLSVGWCNDAYDAGRDARAGRRGKPVADGAVPVRAVWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNA2</accession>
    <name>A0A7K2ZNA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4191 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030564325.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001485.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="235" mass="25028" checksum="0F75E798AC63FE02" modified="2021-04-07" version="1">MARKAKTEGADSAENAGRLKQIALTYKMTRRSDSKIGFIVAGVGIATFGVLLGIGFVIGHPVYLGILGFVLAVLAMAIIFGRRAERAAFGQMEGQPGAAAAVLDRIGRGWTTTPAVAMNRSQDVVHRSVGKAGIVLVAEGNPNRVKGLLAAEKKKMARIVVDVPVHDIIVGNGEGQVPLKKVRTKMLKLPRVLTGPQVTTTNDRLRAMGDLMSNMPLPKGPMPKGMRMPRGGKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNI1</accession>
    <name>A0A7K2ZNI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001497">
        <property type="protein sequence ID" value="MYW33921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="103"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="25153" checksum="D15C61E2AD72578E" modified="2021-04-07" version="1">MVPAPTAPHPLDNPALASLTGPHAHFAERRGRILRYPVDVTPWTAHPAVPDARDWADLAALAGPGGTIGMNTLRGEPPQGWEILHRIGGVQLVDVSVVPEPDAEAVRLGPADVPEMLDLVARTRPGPFLPRTVELGTYLGIRRGGALVAMAGERLHPPGWTEISGVCTDASVRGQGLASRLVRAVAYGIRERGETPFLHTSAANAVAIRLYESLGFQLRAHPEFLSVLAPVSSPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNL7</accession>
    <name>A0A7K2ZNL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_33020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001504">
        <property type="protein sequence ID" value="MYW33964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="16542" checksum="5B57EBB36A8B6B17" modified="2021-04-07" version="1">MAEPKIFTSAQELRDGVGEQLGHSDWLEVDQKRIDLFADATGDHQWIHVDPERAAAGPFGTTIAHGYLTLSLLPALVPQVMRVEGMKMGINYGTNKVRFPSTVPVGSRLRATAVLTSVEEAGGGVQITALVTVEREGGEKPACVAESVSRYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP91</accession>
    <name>A0A7K2ZP91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)H-quinone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_34035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001551">
        <property type="protein sequence ID" value="MYW34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561556.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001551.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="360"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="479" mass="50185" checksum="28EFAB7DD99C6DC5" modified="2021-04-07" version="1">MTRIVIIGGGPGGYEAALVGAQLGAEVTVVDCDGLGGASVLTDCVPSKTLIATAEVMTTFDSSYEELGIIVADDTPHKEHAARVVGVDLGKVNRRVKRLALAQSHDITASVTRAGARVMRGRGRLDGLQAADGSRQVVVTAADGTEERLSADAVLIATGGHPREIPDAQPDGERILNWTQVYDLDELPEELIVVGSGVTGAEFAGAYQALGSRVTLVSSRDRVLPGEDPDAAAVLEDVFRRRGMNVMSRSRAQSAKRVGDRVEVTLADGRVITGSHCLMAVGAIPNTAGMGLEEAGVRLKDSGHILTDRVSRTSAPGVYAAGDVTGIFALASVAAMQGRIAMYHFLGDAVAPLNLKTVSANVFTDPEIATVGYSQADVDAGKIDARVVKLPLLRNPRAKMQGIRDGFVKIFCRPGTGIVVGGCVVAPRASELIHPISLAVDNNLTVEQIAKAFTVYPSLSGSIAEVARQLHTRKLTDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ51</accession>
    <name>A0A7K2ZQ51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination factor Rho</fullName>
            <ecNumber evidence="6">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rho</name>
        <name evidence="10" type="ORF">GT040_35790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001629">
        <property type="protein sequence ID" value="MYW34496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="9">
        <location>
            <begin position="68"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="186"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="445" mass="49048" checksum="559629017845BED6" modified="2021-04-07" version="1">QRPQRQGQGQSQGQGGQGQQNRDNGPQDDFDDEAGGRRGRRGRYRDRRGRRGRDDFASDVQVADDDVLIPVAGILDILDNYAFIRTSGYLPGPNDVYVSLAQVRKNGLRKGDHVTGAVRQPKDGERREKFNALVRLDSVNGMAPESGRGRPEFQKLTPLYPQDRLRLETDSNILTTRIIDLVAPIGKGQRGLIVAPPKTGKTMILQAIANAITVNSPECHLMVVLVDERPEEVTDMQRSVKGEVISSTFDRPAEDHTTVAELAIERAKRLVELGHDVVVLLDSITRLGRAYNLAAPASGRILSGGVDSTALYPPKRFFGAARNIEDGGSLTILATALVETGSRMDEVIFEEFKGTGNMELKLDRKLSDKRIFPAVDVDASSTRKEEILLGTDELAVVWKLRRVLHALDQQQAIELLLDRMKKTQSNAEFLLQIQKTTPGSGNGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ53</accession>
    <name>A0A7K2ZQ53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001626">
        <property type="protein sequence ID" value="MYW34472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="736" mass="78156" checksum="720878E116FD15BA" modified="2021-04-07" version="1">MRGHEHSNNDLSGTVHGFVVQAGSVQGGIHVSGGAAREEVPPPWQLPPSVRITDRTHELRTLELHRCRATEDGHPTLAAVSGLGGVGKTAVALAWLHTLRAEFPGGQLYADLGAQAPDGPADPGEVVGRFLRALGVPAGQVPPVLGERVALYRSLTADRRLVVLLDDAATAAQVRPLLPAGRCVTAVTSRRRMPGLSLDGGHVLHLDPLSPEAAVELLDSTLADGRVAAQPEEARALVLLCAGLPLAVRIAGARLAARPRQGITAMVRALSEEHERLQALAIEGDHDVRAALDLSYQGLPPAAARLYRLLGLHPGREFGGAVARALLGEEAADALDALYDANLLVDVAEASGGERYRFHDLVRLHAAARAAQDESGEERTAALLRIGHHYLANARRAEEIVEPERASLERDFEPECVVEEDFAQRGAEAALDWLEGELPNLMAVVRIARPVGAPELAWQLTDALWPLFPRRKRYREWHEAHQEGLLAAEEAGNEEAVCRMLTSGALGKLASGAHAEGLEMFERAAASFLERGDALGHARTLNYRGLAHQRLGQPDRAAELFARAAGALPACGDLRAGALARFNLADVAFSQGRYEEAVVDAEAARLTLEAAGDPYNAARAAGLTGRACVGLGRLGHAEAELSAALSALRAQAAEFEAARVLGGLAQLSERRGQPHQARQFYREALSLYSSVGRSGSADAEETRARLAALEPAPPTPPDPEVPEPRPSGEAQGDAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQA8</accession>
    <name>A0A7K2ZQA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M48 family metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_35925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001633">
        <property type="protein sequence ID" value="MYW34522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="120"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="31385" checksum="1E9FC0173AE91F6D" modified="2021-04-07" version="1">MNAAPAFLGYAAAVGVLAPRLLLRSGWPQRAPLLAVAVWFALAASFSVCVQLAAAHLATPGAHLHGILYSCRAALGLGGGPDGGTGPSWGLVALTLLLAAHLSGFAFHAVRAYAARARHRDVLDKVGRPSARLRATVVEHAEPAAYCLPGRRPRVVVSSGAVDALSHDELGAVVEHERAHIHGRHHLVLAAAHAFAWIFPGLPLARHLREQIPLLLEMAADDRALRRSPQNALATAMFTLASGRAPRGALAVGGETVLIRLKRVLVPQRSAHPALRCTVGTGALMAPLLPVLLTCHAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQH0</accession>
    <name>A0A7K2ZQH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001631">
        <property type="protein sequence ID" value="MYW34509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="33412" checksum="4CBD46B9E6747E95" modified="2021-04-07" version="1">MDASPDPSAPEPLDRRAELSEFLRTRRARLQPQDVGLPEFGRARRVPGLRREELAQLAGVSVAYYTRLEQGNGRNVSAEVLDAIARALRLSDAEHAHLTHMAKPAQHKKKRRPARVQRVRTGLLHLLDSLEGVPAYVSGARSDILAWNPMAAAVFGDWGALPPEERNWARLVFLSPAYRDLFVEWDSKASDMVSYLRLYAGCHPDDPQLSALVGELSVKNDEFRRLWATHNVKEKGHGTKLIRHPLVGDMALSYETLHLPDDQEQCLVTYHAEPGSESAEALRLLASWGADASHRTART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQK2</accession>
    <name>A0A7K2ZQK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_36310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001647">
        <property type="protein sequence ID" value="MYW34597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="366" mass="37135" checksum="67AECD2ABA79189B" modified="2021-04-07" version="1">GYASSVPAAVLAAAVLGAGTAVMQPALATMLVWCSSTATRTRAFAMQFFLQNLGLGLGGLVGGQLVDVSRPASFTMLFLIEAGMFVVLGVIAVTVKMPRTASIGGGRPADGSAKGGMRALLSHRAMVQLCVLGFVLFFACYGQFESGLAAYGTEAAGIQPSTLGFALAANTAVIVIAQFVVLRLVERRRRSRVIAAVGLIWAFAWIVAGYAGLGHGSQTMATAAFISTYALFGLGEAMLSPTVAPLVADLAPESMVGQYNSAFALCKQLALAVGPAVGGPMGASLHGPYIVTFVLFSLGITVLALRLGRRLTPVQDQPSLAPAPSRVVAVSLPEGGESGAEAADRAVSVTAPTAAATTAAAATAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQN6</accession>
    <name>A0A7K2ZQN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001666">
        <property type="protein sequence ID" value="MYW34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032722">
        <property type="entry name" value="Deaminase_XOO_2897"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14440">
        <property type="entry name" value="XOO_2897-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21496" checksum="5067F8934FCD7BBF" modified="2021-04-07" version="1" fragment="single">PPGPPPGSTPPPGGVHHAETMFANSGPIPVPGPPGPPGPPPGAPQVHQQGGPGGPHTPPPPAYGYPQQPSGLPTVGPGYQAVLRFRAPDGSEQQLIRRSAPGTPHPEWQMLHELRAMNVSPQQVIELHTELESCELPGGYCARMIRETWPQVRITCVAPYGTDHASRQQGMQHLLTHQGELHQVADGPARPAPLRAPLPQMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQY3</accession>
    <name>A0A7K2ZQY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_37080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001683">
        <property type="protein sequence ID" value="MYW34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="28638" checksum="2394EFBBA499C8F9" modified="2021-04-07" version="1">MTVAYDRADVVHGADLRLPRGRVTALIGPNGSGKSTLLRAVARLHKARTGTVTVSAPGDDEPVDALALSRNDFARRITLLAQSRNAPAGLSVRDVVGFGRHPYRGRLRGSDPDGARRIDHALAVTNLTDFADRGVESLSGGQLQRVWFACCLAQDTDVLLLDEPTTYLDLRYQVEILDLVRDLADTHGVTVGVVLHDLDQAAAVADQVVLLSSGRIASSGTPAEVYDSERLTQTYGIRIDVEPDPSTGIPRTRAVGRHHLRTERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQZ9</accession>
    <name>A0A7K2ZQZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001681">
        <property type="protein sequence ID" value="MYW34718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="82" mass="9225" checksum="D896172576D19CD9" modified="2021-04-07" version="1">MGESLRTFVGGTEVEVPNSIPDIRAALPEERREEFDLAINEAGVHEISAVMRHWMLEAVPDPEAERILDRLAQDEAERRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRA5</accession>
    <name>A0A7K2ZRA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl oligopeptidase family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_37745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001707">
        <property type="protein sequence ID" value="MYW34872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="4">
        <location>
            <begin position="112"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="503"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="708" mass="76425" checksum="E3772E698DF90D35" modified="2021-04-07" version="1">MTSPKLSFPRQHARTQRFTLGAPRAFTVSPDETRVIFLRSTSGTDRTNRLWVLDPASGEERLVADPEALLGGSAERLSPQERARRERAREGSAGIVSYAVDAAAELAAFALSGKVYVAELRAGTARALPVPGPVIDPRPSPDGRLIAYVSKGALRVVGAEGQEDRALAEPEDPHVTYGLAEFIAAEEMRRFRGFWWSPDSDRLLVARADDSPVQRWFIADPAHPERKPAEVAYPAAGTPNAEVRLFVTDLEGARTEVVWDRAAFPYLAQVHWSSAGAPLLLVQARDQRSQRYLAVDPESGETRIVHVDEDPVWLDLFGGVPAWAPDGRLVRIADEGGARVLAVGDRPLTGAQLHLQAVLDIGESDILVSAVAGEEAAAPETGESHVYRVNELGIERISEGVGVHSAVRSGDLTVLVSATPDEPGSAAWVVRDGKRLVRIASHAQEPVLAPRVTLTEGGARRIPCAVLLPSDYQESDGPLPVLMDPYGGPHGRRVVAAHNAHLTSQWFADQGFAVIVADGRGAPGRSPAWEKAVRDNLVLTMEDQVEALLGLAERFPLDLSRVAIRGWSFGGYLAGLAVLRRPDVFHAAVVGAPVTDQRLYDTHYTERYLGDPAQQPEVYAYNSLITDEGLSEAAEPARPMMIVHGLADDNVVVAHALRLSSALLAAGRPHEVLPLSGVTHMTPQEQVAENLLLLQVDFLKRSLGLTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRE3</accession>
    <name>A0A7K2ZRE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyroglutamyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001725">
        <property type="protein sequence ID" value="MYW34916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029889371" evidence="2">
        <location>
            <begin position="32"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="423" mass="45922" checksum="35FE47A145C9638D" modified="2021-04-07" version="1">MTHQFPAITRLGLSGVALLLVLAGSALPAVASPADTAPNTAPPTVEEQRLDRAVPQEILRRSGFDALAPRFAHALEGARGYAQAERVVNRHGSALWRRAVDRAQGRGPATGDLSRGDDRPLYWARLALSRELRAWTPRFALDDQRRKALHTALETSSRGQQDVRRHPVRQVKRVLVTGFDPFTLDRDVRIGNPSGASALALDGTLVRTAEGPARIEAVVFPVRWTDFAEGAVERALARQLPHLDLFTTISQGRQGRFDVERTNGAWRGGFPDNENLARTGTVPVTDPATQPQWTSTTLPYRQLTEAETGRFPVYDNTEVTEIPAGATQPVTRPDGPTPGSTARAGGGGDYLSNEIAYRATLLRDRMGLSTLPGGHLHTPVLQFGAGNENPATGEVTDPGFERNRSDIVRQVRALVQTAVSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRN4</accession>
    <name>A0A7K2ZRN4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_37890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001722">
        <property type="protein sequence ID" value="MYW34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="5">
        <location>
            <begin position="129"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="481" mass="52444" checksum="9FFBBA301F622BC1" modified="2021-04-07" version="1">MTVNDDSFTNWMHREEIAESMIPIIGKLHREQDVNVLLHSRSLVNKSVVSILKTHRFARQIAGEELSVTETMPFLRALTTLDLGPSQIDIGMLAATFRADDRGLSVEEFTAEAVAGATGANKIERRDSRDVVLYGFGRIGRLIARLLIEKAGSGNGLRLRAIVVRKGSGQDIVKRASLLRRDSIHGQFSGTITVDEANSKIIANGNEIKVIYSDDPTVVDYTEYGIKDAILIDNTGRWRDREGLSNHLRPGIAKVVLTAPGKGDVPNIVHGVNHDTIKDDEQILSCASCTTNAIVPPLKAMADEYGVLRGHVETVHSYTNDQNLLDNYHSSDRRGRSAALNMVITETGAASAVAKALPDLDAPITGSSIRVPVPDVSIAILSLRLGRETNREEVLDYLRNVSLASPLKRQIDFISAPDAVSSDFIGSRHASIVDAGATKVDGDNAILYLWYDNEFGYSCQVIRVVQHVSGVEYPTYPAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRT3</accession>
    <name>A0A7K2ZRT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001743">
        <property type="protein sequence ID" value="MYW35007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="55"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="23367" checksum="4D3C2B70EBDFC10F" modified="2021-04-07" version="1">MHSDSDGPDLRKEWLQQRTHGALSRFHDTTPLIYRKRIDVPKEVTDWVAGWGSSSLFLTGHIGVGKTHTAWETCRLWLKAFYGPERPWNGAATIYTYRSTALFDALRPDGPDEVRRTLIKTLQDADLVFVDDLAAPKVTEWTQERLFEIFDERYINQRPVIITSDVLPADLGPVTGPRVASRLGEMCRDSVVWLEGDDRRRGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRU1</accession>
    <name>A0A7K2ZRU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001746">
        <property type="protein sequence ID" value="MYW35017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="28382" checksum="281997D784C0574D" modified="2021-04-07" version="1">MPEAPASVASTVLHRITPDGVSWITLNRPEAMNAVTWEQRERVIALLADASADPAVRAVVLTATGRGFCAGADLRGAPAQTRERVPGDVARTIRLGAQRLIAAVLDCEKPVIAAVNGTAAGIGAHLAFACDLVLAADTARFIEVFVRRGLVPDGGGAYLLPRLVGPQRAKELMFFGDALPAADAERMGLVNRAVPEAELAGLAAAWAGRLAGGPTRAIALTKQLVNDSLTADRATAFAAEAAAQEINMTTRDANEGVTSFVERRTAEYRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRW6</accession>
    <name>A0A7K2ZRW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001772">
        <property type="protein sequence ID" value="MYW35096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="111"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="417" mass="45203" checksum="A197849AC7D1C298" modified="2021-04-07" version="1">MGKYRVAVIGGRPAPVAGAKELGIDVVLVHEEGAYDVAVAQHCERIIHGPLDDGPAILELLKPLHAERPFDRVLTTTEPAAESTGFVVDALGLPGVSEFTARALKDKALTRQLLDEHGISPVRYRLVRSAEEIAAFRAEVGDRIIVKPVDGVASLHIHPVDGPEDAENAWQALQEADTSAVIAEEYLDGPVVSVDSFSHAGRHLTIGYSEYRMNERYVEWEVSTPSRYATPWLAELRELTPKLLDAVGLTEGPSHSEFVLTPKGPRVLESHARLAGSGAPELVRRAFGLNLNRMFLTVPLGIDELPQTSPEPLGGAAVRFFTPEPGTVDAIEVDDDAAHEIRRVPKDEKQYVFLPYLDEFTDTEVAAVIGKSVGETVPPLLTVADCVSGYVIASGRDADDAVAKCEATNDRIRFKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS28</accession>
    <name>A0A7K2ZS28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_38985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the melC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001774">
        <property type="protein sequence ID" value="MYW35107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023199">
        <property type="entry name" value="GriE/MELC1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010928">
        <property type="entry name" value="MelC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06236">
        <property type="entry name" value="MelC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW35107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17303" checksum="15E31495E8B5AC82" modified="2021-04-07" version="1">MSRTTDPGGGAPRGTRGPSRRIVLRTVFTAAVAGGTAAVLLPVHDNKPGTASASAQGPGHTAAAAEEFAEMYRGREIRGSVTVLVPAGEAGGGAGAHDTEPVTEIRIDGRPLHVMRRADGTYLSDVTHYESFPTLREAARAAVDELGTARLALPAPDHRRTWHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS90</accession>
    <name>A0A7K2ZS90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001800">
        <property type="protein sequence ID" value="MYW35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="24100" checksum="D7AD8916C4AE73C8" modified="2021-04-07" version="1" fragment="single">MFDPFIAPSGTLLGLLQRGRGDGTLHALAAPRPEALAALNHCVVSDPRHDWQVENRSLYYARLYLDLDGGIEEIERHLGDPDDHTDTDDSRTGLALSVLGHLASYGRDDALALLRRYAATGANWAWALDELALRDDDAGLRSLALPVLGRFPATEEGTAELAAAVRDSFEPRPWRLWADDPREAVGARVRAATEQGSFDRWQRQMRPGGPRPGWSVQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSA3</accession>
    <name>A0A7K2ZSA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001788">
        <property type="protein sequence ID" value="MYW35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="77" mass="7856" checksum="0335A924A0F63DC4" modified="2021-04-07" version="1">ESPGYALVCALVSAGLGVAVVPEMVASLSATPLAVRRLEPAEFRRTISVVHRGDRATAAAATLLALLRSGFGRAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSI1</accession>
    <name>A0A7K2ZSI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001836">
        <property type="protein sequence ID" value="MYW35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="104" mass="10937" checksum="A878582EAB5DB15F" modified="2021-04-07" version="1" fragment="single">MSAAEPPGDGGDQLLVVIDPVARRTDGESVRIAKDVLSAGSHAKICLPDTPEEFARALSRRGSRRPVVVGDDAALLRAVAQLHRERELARGVLSLIPVGAAHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSJ6</accession>
    <name>A0A7K2ZSJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Indole-3-glycerol phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="17395" checksum="D5A29736A5301509" modified="2021-04-07" version="1">MFTSVLMIEKPLTPEDVDFVTTLHGEERISFVVLLQPRGDQADVLLRAIDDVAMGELKEAVREGEEPEGKEAREPAEIGLEYSLRALREAGAEAVGQVIEEHPLDKLKTVVEDAGADEVIVLTAPHYVEEFFHRDWASRARHKVGVPVLKLFAHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZT13</accession>
    <name>A0A7K2ZT13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="93" mass="9735" checksum="35D408D13585C855" modified="2021-04-07" version="1">MTTPLNLTASRRPDGTTVLTAVGEIDMSNAQSLAAALDDAPGPLVLDLSDVEYLDSAGLSVLFQHAERLELIAGPLLEPVLSISGLTDLTTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5Y6</accession>
    <name>A0A7K2Z5Y6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000009">
        <property type="protein sequence ID" value="MYW27761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="264"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="327" mass="34377" checksum="EE517972B0A4426E" modified="2021-04-07" version="1">MSDVTHSHLGSLGLSAQAAALYSRLLETGPLTPAQLAARAGEPEETLTAALSELASVALLAPLGQEGDPVVPLDPTAGLQLLASRRTADLNAGMTAVVAAYESYRRAHSLPPGAPTVEVLEQASLQRKVVELERSAVSQVRSFDTAPYGAATIANPVEIANLGRGVSYRVLYAQSSVETPDYFQGNIVPCTAAGEEARMAPSVPAKMMLVDDRFALVSLSSVHADTHHGALLVHPCSLLPALSALFESAWQSARPLAAREGASTTVLRPLERRLLALLAAGVADEAAARNLDISKRTLARAVERLMSLAGVSSRFQLGVYAKSEGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z635</accession>
    <name>A0A7K2Z635_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alanine--glyoxylate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000018">
        <property type="protein sequence ID" value="MYW27815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="5857" checksum="F4D187129DB09CF9" modified="2021-04-07" version="1">AGGGALAKEMIRVNHYGADATRGAVLSSLAALGAALGDAGRRVDFEAARSAVTETSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z658</accession>
    <name>A0A7K2Z658_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_00700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000020">
        <property type="protein sequence ID" value="MYW27824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW27824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="264" mass="27839" checksum="2FF2B8DF4C86CA8E" modified="2021-04-07" version="1">MSSLSLAVRDSSTMLRRNLLHARRYPSLTLNLLLTPIVLLLLFVYIFGDAMSSVVSGGQGPDRSAYIAYVVPGLLLMTIGSTVVGTAVSVSNDMTEGIIARFRTMAIHRPSVLIGHVLGSVLQSVMSVILVGVVAVAIGFRSVDATALEWLAAFGLLILFATALTWIAVGMGLVSPNAEAASNNAMPLILLPLLSSAFTPVGSMPGWFRPIAEYQPFTPAIETLRGLLLGSEIGADGWLAVAWCVGLAVLGYFWSAAKFDGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z684</accession>
    <name>A0A7K2Z684_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FmdB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000030">
        <property type="protein sequence ID" value="MYW27851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="11617" checksum="171220AE225E19AB" modified="2021-04-07" version="1">MPTYQYQCTECGEGLEAVQKFTDDALTVCPSCDGRLKKVFSAVGIVFKGSGFYRNDSRGSSSSSTPATSASKSSDSGSSSSSTSTGSDTKSSASSSSSASSSSSAPAPASSSSGSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7D6</accession>
    <name>A0A7K2Z7D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_03015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000143">
        <property type="protein sequence ID" value="MYW28270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="23455" checksum="A81C0E92F368549D" modified="2021-04-07" version="1">MPTAPRRTHHAAPPREDVLAAAMATIAARGLDGLTMAGLGREVGMSSGHLLYYFRTKDELLLRTLEWSEDRLGAERRALLAEPGTARERLDAYIGLYLPAGHRDPHWTLWLEVWGRSQNADDDARARQAAIEGAWHRDLVALLAEGVSRGQFRAVDADRFATRLRALLDGFSVHVTVGIPGTGREQVLAQAAEFLDETLTPGPRPGDATSVTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z861</accession>
    <name>A0A7K2Z861_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">GT040_04455</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="WWKE01000199">
        <property type="protein sequence ID" value="MYW28540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW28540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="31368" checksum="14928B9911CC9FBC" modified="2021-04-07" version="1">MSWFESFVLGLVQGLTEFLPISSSAHLRLTAAFAGWHDPGAAFTAISQIGTEAAVLIYFRKDIARIVSAWFRSLTDKEMRADHDAQMGWLVIVGSIPIGVLGITLKDQIEGPFRDLRLIATTLIVMGIVLGIADRLAARDEDGGKHRAVKERKTLKDLGIRDGLIYGFCQAMALIPGVSRSGATISGGLLMGYTRESAARYSFLLAIPAVLASGVYELKDVGEGHVSWGPTIFATVVAFFVGYAVIAWFMKFITTRSFMPFVYYRVALGILIFILVSTGALSPHAGESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z885</accession>
    <name>A0A7K2Z885_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF881 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_04540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000201">
        <property type="protein sequence ID" value="MYW28556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="304" mass="31665" checksum="691788031C936497" modified="2021-04-07" version="1">MSQQPPDRSTPSPPARPDASMSLLNNVMDHSLDDGYAEASARRQADGSAGLPRTLKSKLGLAAGLVVAALVVTLGAAEARVSAPVVAKEREELIDRINAETRAADTLESDVDKLRSDVSERQRKALEQHGGDQGELVALLSGATPVQGPGVKLVVDDAKNTDQGGGGPRESSSFSDTGRVRDRDMQRVVNGLWESGAEAIAINGQRLTALSAIRAAGDAILVDNRPLVPPYTVLAVGNGKNLAAAFRDSADGQYLNALKESFDIRTSLSDQAEVRLPAAPSLIVRTAEPKAAGSDAAESGKGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8D3</accession>
    <name>A0A7K2Z8D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000211">
        <property type="protein sequence ID" value="MYW28606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="85" mass="9015" checksum="1D1FA2C3C47B2574" modified="2021-04-07" version="1">ELNEAFAAQVLACTRELGLGATDHEQRINVNGSGISLGHPVGATGARILATLTRELHRREARYGLETMCIGGGQALAAVFERVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8G5</accession>
    <name>A0A7K2Z8G5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidinol-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisN</name>
        <name evidence="11" type="ORF">GT040_04850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000213">
        <property type="protein sequence ID" value="MYW28613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561033.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000213.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="28969" checksum="A29A903B34473D34" modified="2021-04-07" version="1">MPDYHDDLRLAHVLADAADAATMDRFKALDLKVETKPDMTPVSEADKAAEELIRGHLHRARPRDAILGEEYGVEGTGPRRWVIDPIDGTKNYVRGVPVWATLISLMEAGENGFQPVVGVVSAPALNRRWWAAKGAGAYSGRSLTSATRLHVSKVETIADSSFAFSSLSGWEEQGRLDGFLDLTRACWRTRGYGDFWPYMMVAEGSVDICAEPELSLWDMAANAIIVQEAGGRFTDLEGTDGPGGANGAASNGLLHDELLGYLNQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8H8</accession>
    <name>A0A7K2Z8H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyphosphate kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000216">
        <property type="protein sequence ID" value="MYW28631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="166" mass="19293" checksum="B662652467C140B5" modified="2021-04-07" version="1">GVERVMGFCTTREYLEFMHQAPGFERMLARDGIHLMKFWFSVSRNEQRNRFMIRQIDPVRRWKLSPVDLASLDKWDEYTEAKELMLFHTDTADAPWTVVKSNDKKRARLEAMRHVLDRFDYPGKDPEVVGVPDPLIVGPASRLFEEGEMDARLLGPVASTSRTTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8X6</accession>
    <name>A0A7K2Z8X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000255">
        <property type="protein sequence ID" value="MYW28799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="5"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="471" mass="50253" checksum="E15173169880D648" modified="2021-04-07" version="1">MSEQRKSPFATVNPYTGETLAEFPAIEGAEVDAVLGTAGDAFDAWRTRSIEERAALVGRVAGLMKERKETLARLITLEMGKLISEARGEVDLAASILAYYAEHGPGFAAREPLDVEEGEAYLVNEPLGVLLGVMPWNFPLYQVVRFAGPNLVLGNTVLVKHAGICPQSALALEVLFRDAGAPEGVYTNLFVSHDEISRIIDSPVVKGASLTGSERAGAQVAERAGRNMKPSLLELGGSDVFIVLDGENLERTVGAAVAGRMANTGQSCVASKRFIVLAEVYDEFVEGMRGTFAALTPGDPSDEATTLGPLSSEQAASDLAEQIRETVEQGAELVIGGGRIDRPGAFVQPTILTGVKPGMRAYAEELFGPAAVIYRVEDEDEAIALANDSRYGLGGSVFCSDVDRGRRVAERVETGMVWVNHPTSTQPDLPFGGIKRSGYGRELSKLGMQEFVNRKLVRVLPPDAELSGIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z938</accession>
    <name>A0A7K2Z938_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000268">
        <property type="protein sequence ID" value="MYW28859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043767">
        <property type="entry name" value="DUF5713"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18977">
        <property type="entry name" value="DUF5713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="12886" checksum="59DAC3236528B6E0" modified="2021-04-07" version="1">MTITNQQVAEHAFLLPLYEDDYYPDHVLDRGRAVLLRLCERIEAERPADLAVLYRLTEGATEEFNALEAEFEAAGSEIETVAREEIGEAFWFIAQAYGFEDADGEELIAAREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z982</accession>
    <name>A0A7K2Z982_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000263">
        <property type="protein sequence ID" value="MYW28845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="298" mass="31445" checksum="B8023034D341547B" modified="2021-04-07" version="1" fragment="single">MRSPKLAALELRRFRRGKLPAAALVALLLLPLLYGALYLFSFWDPYGNLDKLPVALVNNDKGATNDGKRVEAGDEISDKLLDSKVFAWHEVSSAEAEKGVEDGTYYLSLTMPADFSKKIASSGGDSPETGALQVRTNDANNYIVGQISKTVFGEVRNAASTNASRGFLDRIFVNFSDLHDKTADAAKGADELKGGISKAKKGSKELADGLKDSKAGTERLSDGIVKLNTGAGEVASGARQVAGGTQQLADKVNGAAGEARPFFTYFKENGKSIGEAARLAADGAKTARENLGKLVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9E5</accession>
    <name>A0A7K2Z9E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridoxal-dependent decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_06585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000300">
        <property type="protein sequence ID" value="MYW28948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="482" mass="52273" checksum="2271D192891B30BC" modified="2021-04-07" version="1">MRSHLLNNTTAEHYRRTVTAGVDRVAAEIAATERPFSGVGVDELSPVVDAIDLDRPLGDAAAALDELGEVYLRDAVYFHHPRYLGHLNCPVVIPAVLGEAVLSAINSSLDTWDQSAGGTLIERRLIDWTTERIGLGPAADGIFTSGGTQSNLQALLLAREEAKIRPEHYTRLRIFTSECSHFSVQKSAKLLGLGPDAVVSVPVDSNKRMQAVALAHALERCVAEGAVPMAVVATAGTTDFGSVDPLPEIAALCEQFATWMHVDAAYGCGLLASRERRGLLEGVAHADSVTVDYHKSFFQPVSSSAILVRDRATLRHATYHAEYLNPRRMAEERIPNQVDKSLQTTRRFDALKLWMTLRVMGADGIGELFDEVCDLAAEGWKLLAADPRFDVVVQPQLSTLVFRYIPSGATSPDGIDRANLYARKALFASGEAIVAGTKVGDRQYLKFTLLNPETTVADIAAVLDLISGHAEQYLGDSLDRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9H9</accession>
    <name>A0A7K2Z9H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000305">
        <property type="protein sequence ID" value="MYW28988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030564685.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000305.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="305" mass="30808" checksum="F2C56B224011A44A" modified="2021-04-07" version="1">MLVLVAPGQGAQTPGFLTPWLDLPGAADRIAAWSDAIGLDLAHYGTQADADEIRDTAVAQPLLVAAGLLSAAALDAPSPDVVAGHSVGEITAAAIAGVIDDEAALRFVRTRGLGMAEAAAVTETGMAALLGGDPAVTVPHLEKLGLTPANVNGGGQIVAAGTAAQIAALEADKPEGVRRVVALKVAGAFHTHHMAPAVEKLRAAVGDLTVTDPTVRYVSNADGHTVATGTEVIARLVGQVANPVRWDLCMETFQKLGVTALVELSPGGTLTGLAKRALPGVKTLALKTPDDLDAARALISEHAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9K7</accession>
    <name>A0A7K2Z9K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000319">
        <property type="protein sequence ID" value="MYW29051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="18170" checksum="7A99D77EC928959F" modified="2021-04-07" version="1" fragment="single">MAEAPAAAPLVRATPNSLREVVASRELANLTGPIGSGKSRLAAGLGPVSLLDLDRPGALERLSTALAEYTPAPLVVDSADDDRALAALEPLRLRPPGSGRPVLVISRRSLLARPGWADTGVAVVETVPWPDARIGRLATEARVTDARCRELIVRLAAGNPLIADAACRAFHAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9S5</accession>
    <name>A0A7K2Z9S5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000320">
        <property type="protein sequence ID" value="MYW29052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="28996" checksum="DA981A9329CCE8F3" modified="2021-04-07" version="1">IRLAAAEGARVVCLQELTLSPYFAVVRRADHPAPAAPEELLTGPTFTFAAEAARAYGVYVHASLYEKAPAPGGEDDGLGYNTAILVAPDGTLAQRTRKTHIPVTEGYYEDDWFRAGPAGDDAFPLVTVDEARFGLPTCWDQWFPELARAYSLAGADVLVYPTAIGSEPGFPGFDSQPLWQKVITGNAIANATFMIVPNRIGAERGLTFYGSSFIVDPYGRVLAQAPRDEPAVLVADLDLDARRDWLELFPFLTTRRPDAYGPLTVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9T0</accession>
    <name>A0A7K2Z9T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA carboxylase subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000352">
        <property type="protein sequence ID" value="MYW29116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="35" mass="3566" checksum="A7922FF8C729A356" modified="2021-04-07" version="1" fragment="single">MSLTSAESVLRVEKGHAAPEELAAITAVLMARAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA90</accession>
    <name>A0A7K2ZA90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_07810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000360">
        <property type="protein sequence ID" value="MYW29185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="197"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="750" mass="78618" checksum="FDDAE49144B51484" modified="2021-04-07" version="1">MGGWTRFVTARPRIALLAALVITALAVFAGSGVADRMGSGGWQAPDAESSYATEALEREFPASQPNLLLLVDSGTASVDDPAVAAEAARLTERLAAEQGISGVTSYWQTKAPALRAEDGREALIAARIGGDETEAGETLERMAPAFAGESGPVKVSVGGPVAVQHEMQTIIQEDLLRAELIALPVTLILLVMVFGSAIAAMLPLLVGIVAILGTNAVLRGLTEFTDVSVFAMNLTTALGLGLAIDYALFIVRRFREELDAGADTRTAVGTTLRTAGRTVLFSALTVAVSLSAMLVFPQYFLRSFAYAGIAVVLLAAAAALILLPAALMLLGPRVNALDLRRLLRRGKKKEASAGETGRGWARFAELVMRRAPVFAIVTAVGLVLLGLPFLGVKFGTADDRQLPAGAESRVVQEHIRDGFPGSPSGGLEMLVEGEGTPAAYAALKDRIEKAPGVERVEGPVMADSAAYFSVLPEGEAVGEETQQLVRDLRAMPADSFDTSVTGTAAVLVDSKDAIADRLPWAIAIIVVVTLLLVFLLTGSVLIPIQAVVLNALSLTAMFGAVVWVFQDGNLSGILAFTSTGDIETTLPVLMFCVAFGLSMDYGVFLLSRIKEEYDRTGDHERSVTFGLSRTGGLITAAAVILAVVMVAIGTSRVTNTKMLGLGIALAVLMDAMVVRSLLVPAVMKLTGHATWWAPKPLRAFHQRFGLSEGESAPAGSSGTKGEPGGPEEPTTEGEIPEAGTRDEEKVTAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAD1</accession>
    <name>A0A7K2ZAD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000367">
        <property type="protein sequence ID" value="MYW29225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="20712" checksum="790791BD0F6D37C0" modified="2021-04-07" version="1">MIALLVVACEVAFWVLLAAGLALRYVARKPRLGAAVLLCEPLLEVVLLVVTVIDLRNGAEPDWKHGLAAVYIGFTVGLGHHTIKKVDAWVAHRWFGGPPPVKPPKYGTARAVHEWRTAARWILAAAVALGLLQAAVWYVGPGGAVSSLQGWQQKMLLVIGINVIIAGGYTLFPKQAPKNTDAAVEREPADRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAS1</accession>
    <name>A0A7K2ZAS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-glyceraldehyde 3-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000421">
        <property type="protein sequence ID" value="MYW29471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="30057" checksum="D2910F6F7DB42DC5" modified="2021-04-07" version="1">THFDLANNYGPPPGSAELTLGRALAGDFVKLRDELVISTKAGYHMWDGPYGEWGSRKYLRSSLDQSLKRLGVEYVDIFYSHRPDPDTPLDETMGALDTAVRQGKALYVGLSNYSAEETRRAAAILKNLGTPLLIHQPRYSMLDRRPEDGLLTALDELGVGSIAYSPLEQGILTDRYLNGIPAGSRAAGDSPFLTSDALTPQLVERLRALDAVAKERGQSLAQLALAWVLRGGRLTSAVVGASSVTQLENSVEAVRNLEFGEDELTRIEELLAEAGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAU9</accession>
    <name>A0A7K2ZAU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PspC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_09120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000414">
        <property type="protein sequence ID" value="MYW29432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="9">
        <location>
            <begin position="302"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW29432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="432" mass="46192" checksum="C3FDC870DCE70B2B" modified="2021-04-07" version="1">MPAATARAAHSSLASDPEEPPLRKLYRSADGRMLGGVARGLAGHLGLPVAWVRFVFLGLLLSDGLGALLYAVFWIVVPLGVGGVGGVHAPRSVFETAADGRRKLRKPDPGQVFALVALLIGAVVFVANVDMGSEADRYIWPTLLIGAGSVLVWRQADNARRARWIEVGRRRRLLQLARALAGVALVGLGLAVFMVVRGSAAQLGNVLTAAIAVLTGIALLAGPYLVRMVQDLSEERLMRIRAQERAEVAAHVHDSVLHTLTLIQRNADDGGEVRRLARAQERELRNWLYNPEGTGKDEDDEPETLAEAVKRAAAEVEDKHGVPLEVVVVGDCPLDDKLGAQMQAAREAMVNAAKYGGEGGAVQVFAEVEGATVFVSVKDRGPGFDLDEVPADRMGVRESIIGRMQRNGGTARLRSVPGGGTEVELEMERASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAZ4</accession>
    <name>A0A7K2ZAZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ORF">GT040_09695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000450">
        <property type="protein sequence ID" value="MYW29541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511997.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000450.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="356" mass="38268" checksum="57710782D816F859" modified="2021-04-07" version="1">MRQILFAGAIGLFLTLVGTPLLIKLLARKGYGQFIRDDGPRTHGSKKGTPTMGGIAFILATIIAYVLAKVITGEDMRYSGILVLFLMAGMGLVGFLDDYIKIVKQRSLGLRAKAKMAGQLIVGIAFAVLSLQFADSRGNTPASTRLSFVEDFGWSIGPVLFCVWALFMILAMSNGVNLTDGLDGLATGASVMVFGAYTFIGLWQFQESCANADNLTNPSACFEVRDPLDLAVVAAALMGACFGFLWWNTSPAKIFMGDTGSLALGGALAGLAILSRTEFLLAILGGLFVMITMSVVIQVGSFKMTGKRVFRMAPLQHHFELKGWSEVLVVVRFWIIQGMCVIVGLGLFYAGWAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBU8</accession>
    <name>A0A7K2ZBU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_10965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000497">
        <property type="protein sequence ID" value="MYW29788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="343"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="555" mass="60259" checksum="7961BC0EDB41DAE5" modified="2021-04-07" version="1">MSHPTAPSASVAVSHLTFRWPDGTSLFDGLSLTAPRGRTGLVGTNGTGKSTLLRLLAGQLRPAEGSVTVGGNLAYLPQNITLDTELRVDGALGIAERRAALRAIESGDVREEHFETVGDDWDVEERALATLGSLGLGAVELDRTVGQLSGGETVLLRLAALLLERPDVLLLDEPTNNLDLFARRRLYDAVDSWRTGILIAVSHDRDLLERVDRIAELRSGAVNWYGGGWSAYQDALATQQEAAGRMLRSAEADVRRQQRELEETRTKVARRQRHDKKLDGQRKAPRIVAGERKRSAQESGDRLRGLHEDRLDEARERREEAAEAVRRDAEIKVSLPHTAVPAGRTVLTVRDLSLTYGRLREGSLQVKGPERIALVGRNGAGKTTLLRTLTGELAPSSGVAVVSVPLKFLPQRLDILDDALSVAANVARTAPGTTDNQIRSQLARFLFKGARAEQQAGTLSGGERFRAALAATMLAAPAPQLLLLDEPTNNLDLAGVRQLTSALESYEGALVIASHDLPFLESLGITRWILLEDELRETDAEEVRQLFDGSGQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBV2</accession>
    <name>A0A7K2ZBV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000506">
        <property type="protein sequence ID" value="MYW29836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="250" mass="26885" checksum="90F1850442368FE3" modified="2021-04-07" version="1">MISEPELIGEFGPERTAEAVGDFDRKPASERRAGHGLLWGVAGALVASAVWATAVFAYGDGVARKPDARGYRVDGRSCSAMQVKALTASVGKHEDAPALAPGRIEHPALHQVRCFIGLVSEEGAETYAKGWSVNAHVGLTVELYKESDPRSEFEAREGPSALTDGEEKRPELVPNLGDRAYLLVEDGEGTRLSVLDGAVVLTLTVSAAMNRTEPEADEEPDEWPDSPAPESFHADMISDMRDVMEKLKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC16</accession>
    <name>A0A7K2ZC16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_11305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000510">
        <property type="protein sequence ID" value="MYW29852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029674186" evidence="8">
        <location>
            <begin position="23"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="26876" checksum="A1F3EFA0ADC557F2" modified="2021-04-07" version="1" fragment="single">MGRLPVAPVCLTVTAVVGAVCALSLGTPYVPPGRLLTTLGSDGLAGLVVTELRLPRMVLALVAGACLGAAGLVLQEALRNPLAVPEMLGVSSGAALGVAAPLVLALAVPLGLQPFLALAGAAFGGLLTLVAAGFGRSPSSVLLTGAAVAAALQAGLLVLMVMADQLDLQLIYRYLLGSLSARTWDDVTGLLPWLAVAVPALVLCVPVLGVLRLGDDDARALGVRVERARVAALGIAVVLIAPVVAVCGPVAWVGFLAPHLARRLRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC57</accession>
    <name>A0A7K2ZC57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_11760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000546">
        <property type="protein sequence ID" value="MYW29940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029878352" evidence="7">
        <location>
            <begin position="39"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="117"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW29940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="30437" checksum="AF0BD1B6113DC25F" modified="2021-04-07" version="1">MRIKRTNPRHNQARRVRTTAVLAGFAAVAALTVPTASAEPTGTFSATQLSTASDAVLGADIAGTAWNIDPKTNRLVVTVDSTVTQAEIAQIKKAAGTNASALTIERTPGTFNKLISGGDAIYSNTGRCSLGFNVRSGSTYYFLTAGHCTNGSSTWWANSARTTVLGTTAGSSFPGNDYGLVRYTNTTIPKDGTVGGQDITSAANATVGMAVTRRGSTTGTRSGSVTALNATVNYGGGDVVTGMIRTNVCAEPGDSGGPLYSGTRAIGLTSGGSGNCSSGGTTFFQPVVEALNAYGVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCN9</accession>
    <name>A0A7K2ZCN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="140" mass="15636" checksum="59BE270B68E58889" modified="2021-04-07" version="1">MPQNPTPAAAGDTNPTTPLTPERERMIRIWHEELFRLQDRTAVARREALGDLLAEVDRLRAELDKAAAFCAQRAEYITSILNCHPNNDHDYYRWQGHAESRRQLSGQLGLPVAWPAEMEPRTAPAPAEASAPSQREAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCT7</accession>
    <name>A0A7K2ZCT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1996 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000601">
        <property type="protein sequence ID" value="MYW30166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029794976" evidence="2">
        <location>
            <begin position="44"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="293"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="537" mass="56713" checksum="B00A94E516B3CD17" modified="2021-04-07" version="1">MRRTARTPRTSRKKRSSLANRAIAASAALILGGGGLVAVNVYASAGEGPSGSPPTTRAQNTGRQMSTIDCPDAGNELPDVPEQARPEVDRELAAMDTQITDAYRQFADRKEQISQEPGLAENAVLGPLRNKRTASLDRIGIAIGRVGERPAGIESLAGCSLRADDSASGGPGGNPGSGTGDGGNGSDGGNGGNSDGGQDDGQGQDQGQNQGQGDDQGQGDNQGQGDNQGNGQDPGQGQGGQGGNGPEPSDFVDIQSVQPNVQRPRQRRGGSRGTFSTDCGRNENGKFNPDNVIVAPGVSNGAHHMHDYIGNQANDAFASDDDLANGATTCRNQGDRSTYYWPVLRLQNGQNEADANADGGGKDQNVGEIQTPSQVTLKFVGSPVGRVTAMPRFLRIITGDAKAFTNGDANANASWSCTGFENRQLKDKYPICPEGSQVVRTFAFQNCWDGQNTDSANHRTHVAFAQPNGRCPSGFRAVPQLVQRIVYDVPPGPGFAVDSFPEQLHKPITDHGDFINVFDQRLMKKMVRCINDGRRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD45</accession>
    <name>A0A7K2ZD45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000647">
        <property type="protein sequence ID" value="MYW30291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="12700" checksum="03751D363DC3C8EA" modified="2021-04-07" version="1" fragment="single">MTTTVGLLYPGHAAEDDFPRIEITLDTDIRLPLFSTEAAEDSYRRGALLESGAPDRLAEGVEELRLAGAEALVWASPGGSFAYGWAGAHNQIATLARSAGLPASSTAFGFVHAVRELGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDG8</accession>
    <name>A0A7K2ZDG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ptsP</name>
        <name evidence="20" type="ORF">GT040_13930</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="WWKE01000657">
        <property type="protein sequence ID" value="MYW30359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="251"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="438"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MYW30359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="556" mass="57252" checksum="7F38D76048F24741" modified="2021-04-07" version="1">METTLRGVGVSHGVAIGEVRHMGTAVLEPPAKSIPAEEAGREQGRARQAVEAVAADLIARGNLAGGEAQHVLEAQAMMAQDPELMSDVDRRIAVGSTAERAVYDAFAAYRALLANAGEYLAGRVADLDDVRNRIVARLLGVPMPGVPDSDEPYVLIARDLAPADTALLDPTLVLGFVTEEGGPTSHSAILARALGVPAVVALPGAGELAEGTVVAVDGSTGEIFVDPSAEKRAEMEAAAAARKAALSASTGPGATSDGHKVPLLANVGGPGDVPAAVEAGAEGVGLFRTEFLFLDDSKQAPSEEKQVAAYRAVLEAFPEGRVVVRVLDAGADKPLDFLTPADEPNPALGVRGLRSLLDHPDVLRTQLTALAKAAEGLPVYLEVMAPMVADRTDAKAFADACREAGLQAKFGAMVEIPSAALRARSILQEVEFLSLGTNDLAQYTFAADRQVGAVSRLQDPWQPALLDLVALSAEAARAEGKSCGVCGEAAADPLLACVLTGLGVTSLSMGAASIPYVRATLAKFTLAQCERAANAARSADSAEEARNAAQAVLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDH3</accession>
    <name>A0A7K2ZDH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3000 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000661">
        <property type="protein sequence ID" value="MYW30382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241926.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000661.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021555">
        <property type="entry name" value="DUF3000"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11452">
        <property type="entry name" value="DUF3000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23207" checksum="9B52DC76E93E20A3" modified="2021-04-07" version="1">MAPAQGQFSDHSDGADSKDSAEGPPVPPAFRSAVDALRSARLRPELEVETTRPPQRLAPHAYALEAAVVDGEDDLADGRLVLLHDPAGHDAWQGAFRLVTLVRAELEPEMAADPLLPEVCWSWLTGALDARGLSYGEAGGTVTRAGSHYFGALSARRPATQIEIRASWTPREGRGGVPDAASHLMAWGDLLCQIAGLPPSDPTDAAVVTLPQRRGPQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDM7</accession>
    <name>A0A7K2ZDM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_14285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="141"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="245" mass="27029" checksum="99D715864F219626" modified="2021-04-07" version="1">MSPAEDDPQRILIVDDEPAVREALQRSLAFEGYGTQVAVDGYDALAMAEAYAPDLIVLDIQMPRMDGLTAARRIRATGSTTPILMLTARDTVGDRVTGLDAGADDYLVKPFELDELFARIRALLRRSSYAASAAGAEAPDDDVLSFADLRMDLATREVTRGERRVELTRTEFTLLEMFLAHPRQVLTREQILKAVWGFDFEPSSNSLDVYVMYLRRKTEAGGEPRLVHTVRGVGYALRTGGSGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDP0</accession>
    <name>A0A7K2ZDP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11 12">Xylose isomerase</fullName>
            <ecNumber evidence="4 11 12">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">xylA</name>
        <name evidence="15" type="ORF">GT040_14570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11 13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="4 11 12"/>
    <dbReference type="EMBL" id="WWKE01000680">
        <property type="protein sequence ID" value="MYW30473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013453">
        <property type="entry name" value="XylA_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02631">
        <property type="entry name" value="xylA_Arthro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="14">
        <location>
            <begin position="42"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW30473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="388" mass="43064" checksum="65FF810BEFD04637" modified="2021-04-07" version="1">MTERFTPTPEDKFSFGLWTVGWQGRDPFGDATRAAIDPVESVQRLAELGAWGVTFHDDDLIPFGAPETEREAIVKRFRQAVDASGLVVPMVTTNLFTHPVFKDGGFTANDRDVRRYALRKTLRNIDLAVELGATTFVAWGGREGAESGGAKDVRLALHRMKEAFDLLGDYVTEQGYDLRFAIEPKPNEPRGDILLPTIGHALAFIERLERPELVGVNPETGHEQMAGLNFPHGIAQAMWADKLFHIDLNGQSGIKYDQDLRFGAGDLRQAFWLVDLLESGYEGPRHFDFKPPRTEDYDGVWASAAGCMRNYLILKERAAAFRADPEVRAALRASRLDELARPTAGDGLAALLADRTAYEEFDVDAAATRGMAFEALDQLAMDHLLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDS4</accession>
    <name>A0A7K2ZDS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000698">
        <property type="protein sequence ID" value="MYW30507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="111" mass="11360" checksum="B4E50D0B33660F95" modified="2021-04-07" version="1" fragment="single">MLETVGALTSSPWIYVVVAVSVLLDVFLPLLPSGVLVITAATAAAAGSTGVNGSGNATGEVPSLVVLILCAATASVLGDLVAYRLAWRGGDRLDRAIARSRRLTKAQERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDV5</accession>
    <name>A0A7K2ZDV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_14935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000714">
        <property type="protein sequence ID" value="MYW30540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="337" mass="36815" checksum="07A7A80BB6E1C5C6" modified="2021-04-07" version="1">MRADRLVSLVLLLRQRGRLSATALAQELEVSTRTVLRDIEALSAAGVPVHAERGRYGGFALLPGFRTELTGLNHDEALALLVAGSRRGAQAFGLGSALASAMLKVVDALPESHRDTAAGVAERLLIDPETDLLARRLEGDDVPDPIAGEVRRAVFAGRKLRIRYAAVGRTPRWRTVDPIGLVTVREQGYLLATRSGEDRTYRLSRILAAEELAEPAERPERVDLDRAWQERGTRFRTGGDQVTVLVRVHPARREELVGTALAVLAEDAEKAEEGQSGAEGAVDGWLRLEVTFQDARHAEWVLWKLAADAEALSPQWLRTALHGRATALAARYGAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEA9</accession>
    <name>A0A7K2ZEA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_15735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029729944" evidence="6">
        <location>
            <begin position="38"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="153"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="401" mass="40401" checksum="E7DB83D9CB5F8D83" modified="2021-04-07" version="1">MAKHQRTITRRTKLTAAITAVAAAAGVTLFGTSFAGAAPAPMGTVYGADAETAVSGSYIVMLGEKADKSKLAKQYGGKLQRNYSSSINGFSASGLSETEAKRLAADPSVAKVVQNKKFSINATQENPPSWGLDRIDQAETAGDKAYNYPDAAGEGVTAYVIDTGVRVTHEDFEGRATSGFDAVDNDDDADDGNGHGTHVAGTIAGAAHGVAKKAKIVGVRVLDDNGSGTTEQVIAGIDWVAANASGPSVANMSLGGGADPALDEAVQKAIAAGITFGVAAGNESSDAGQGSPSRVPEAITVASSTEGDEQSSFSNFGSVVDIYAPGSDITSTWNDSDTGTNTISGTSMATPHVVGAAAVYLAGHPDATPEAVATALTEGATPDAISNATEGTANKLLKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEB6</accession>
    <name>A0A7K2ZEB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_15570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000728">
        <property type="protein sequence ID" value="MYW30659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029894105" evidence="1">
        <location>
            <begin position="38"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="118"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="529" mass="56675" checksum="89EC4DD4C65C0201" modified="2021-04-07" version="1">MRYAEKIRIPHSPAAARSAAAAGLALAVGLTATPALAAPATRTAGTEAHGGLDRYYDQRLSWGTCVRSPDDTTGRELDAAGVQCANVTVPLDYTAPRGRTITVAVSRLKATDSRHRIGAILLNNGGPGGTAVESPPAIRTAMKKVGARYDIVGFDPRFVGRSTPLDCGWPVSFPWFSAGAGRAGFDRHVALSKSLAAKCRATNASVLPHVTTRNTARDMDVIRGALGERKISYLGYSYGTYLGTVYTQMFPGRYDRVVLDGAIDPHAYGPRLLKDAVQENEQALSAWAVWAAGRHTTYGLGRTRTAVLATIDRVMAKAARGPLTVGTAPDTFRLDDTRIPTLLFMGVADDTDASRAFLAEQVSVLSKAEKGQQAALSPEFTEQLRFALTGEGSASGSVQMAIICGDGPAPRSPELYWRDIQRARAAHPLFGPLTENIGPCAFWNTPRENPTRIRRDAPALIVAATGDPRTTYRGSVALHDQLPSSRLLTLKNANRHALYGEYGNACVDGKVNRYLETGRLPGRDEVCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEN3</accession>
    <name>A0A7K2ZEN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">amt</name>
        <name evidence="11" type="ORF">GT040_16390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000764">
        <property type="protein sequence ID" value="MYW30811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW30811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="450" mass="46449" checksum="F0BBB824E4EDEB16" modified="2021-04-07" version="1">MPPGITTLAADAPELSAANTGFMLICSALVMLMTPGLAFFYGGMVRVKSTLNMLMMSFISLGIVTILWVLYGFSLAFGSDIGSVIGWSSDYVGLSGIGITELWDGTTIPVYVFAAFQLMFAILTPALISGALADRVKFTAWALFIVLWVTIVYFPVAHWVWGSGGWLFELGVIDFAGGTAVHINAGAAALGVIFVIGKRIGFKKDPMRPHSLPLVMLGAALLWFGWFGFNAGSWLGNDDGVGAVMFLNTQVATAAAVLGWLVYEKLRHGSFTTLGAASGAVAGLVAITPAGGSVSPLGAIAVGAIAGVLCAMAVGLKYKFGYDDSLDVVGVHLVGGIIGSILVGFFATGGVQSDAKGLFYGGGVDQLGKQVVGVVAVLAYSLVVSGLIALVLHKTIGMRVSEDDEISGIDQVEHAETAYDFSGAGGGTVSRTTAPATDPTAAPKAKKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEN5</accession>
    <name>A0A7K2ZEN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000762">
        <property type="protein sequence ID" value="MYW30796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="241" mass="26457" checksum="35C43E10A863CB3F" modified="2021-04-07" version="1">MVTDTPLTPTPRLALDIPQLVVGEFTDRAEFERLLPGTFGSQEWLGSENDDLLFDNGSRELVGVGLHLPAVSAPAGAWIRLSTEPRAVRGGLRAEAAHDFALAQTRVLCCDPEATELACLRDLAVLDTPLDARIGIAPDLALLVQAGAVVGWSLADPVRYLTTGYAVADQAPPAPSTRRRLAECLALITRPLVDDVMDKEPDAWHRLRTTERALREQREDLNRAAALHRLVARLIEDYENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFP3</accession>
    <name>A0A7K2ZFP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ORF">GT040_18360</name>
        <name evidence="14" type="ORF">GT040_25045</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000861">
        <property type="protein sequence ID" value="MYW31183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001174">
        <property type="protein sequence ID" value="MYW32447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW31183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW32447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="275" mass="30715" checksum="608739FE795A2AFB" modified="2021-04-07" version="1">MQKELLVTDAQTLAFETNCHLFKDCGFHAPSVWSFMFEPLFTIGPVEFNKPMLLAIIGTFAILAFFWAGFSKPKVVPGKLQMVAEALYDFVHRGIAREVIGKKGEPFVPLLVSLFFFVWMLNLWAIIPIAQFPVSSVIAYPVGLALVVWVTYMTVTFRSNGFVGGIRNLCVPSGLPKPIYVLLTPLEFISNVFVRPFTLAVRLFANMFAGHILILIFTIATWYMLGTVLGTVYAGASFIMTLILTVFELFIQALQAYVFTVLTATYLSQALEEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFQ1</accession>
    <name>A0A7K2ZFQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="16" type="ORF">GT040_18350</name>
        <name evidence="17" type="ORF">GT040_25055</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000861">
        <property type="protein sequence ID" value="MYW31181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001174">
        <property type="protein sequence ID" value="MYW32449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MYW31181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW32449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="19604" checksum="A7B928C49057531D" modified="2021-04-07" version="1">MMYLAAEKAQDPLLPVWPEIVIGLICFGIVFFVFSKKLLPVINKTLDERREAIEGGIEKAEAAQTEAQSVLEQYKAQLAEARHEAARLRQEAQEQGAVIIQEMKAEGQRQREEIIAAGHAQIEADRKAASSALRQDVGKLATDLAGKLVGESLQDHARQSGTVDRFLDELEAKAEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFY2</accession>
    <name>A0A7K2ZFY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18650</name>
        <name evidence="3" type="ORF">GT040_27485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000869">
        <property type="protein sequence ID" value="MYW31240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001291">
        <property type="protein sequence ID" value="MYW32917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13586">
        <property type="entry name" value="DDE_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="10159" checksum="A47A065FBEE5CD6F" modified="2021-04-07" version="1">RAYLRRRGITATIPERTDQLAGRRRRHERPCTFDKSVYRRRNVVERCFHRLKQWRGIATRYDKRPDRYRAAITLASTLIWLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFY9</accession>
    <name>A0A7K2ZFY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NrdH-redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000868">
        <property type="protein sequence ID" value="MYW31238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561071.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000868.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="84" mass="8984" checksum="A8E06F5E08AF2506" modified="2021-04-07" version="1">MAGTVTMYSTTWCGYCRRLKGQMDREGIAYNEVNIEHDADSAAFVEKANGGNQTVPTLLIVSEAGTESVMTNPSLAQVKQALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG21</accession>
    <name>A0A7K2ZG21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000873">
        <property type="protein sequence ID" value="MYW31268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="196" mass="21629" checksum="61459ED0BAF778CC" modified="2021-04-07" version="1">MADGFIQWYREDLTTAEFAEQVEIFSEFGIKLIHPNKNAALVLDIEGDDVPMSQEELGSLIGRRFATLTFNWWLTADTNVIDTYEAVPVGRETQTLWLDGLYPDEVQRVESAVMAAATRLPVPTRAVIVDRLGISDPGDWDSIALWDGTHVPTSPDHVLALDPIAERIRHAAPGLRKEDTGGGGLSRLVPLRDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG76</accession>
    <name>A0A7K2ZG76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lonely Cys domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000881">
        <property type="protein sequence ID" value="MYW31299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="911" mass="97279" checksum="2BEBDE81F83BC4D5" modified="2021-04-07" version="1" fragment="single">DPMEGVESTSVPTAPAVPVPAAPASVRALQPLPPRTLVAYGRDETSPSAQGDRTLELLAAQVAATGLRNRRAGASLPRVEVTGYGADIRPDRPSSGSPARRRATTARHRFTRLLAAELERLQRDLPADAPRLTAQEFGIVVKAMARVPADWVGTGALAQVTRAELGRQATVVLHQSPDAVAVQKLDSLRRRDRALRDRPLDVDAIARRVLHLDPGAPVQQDTRQELFGLVGRATAAGRATGFPALAAYHLSGLGVTAPGRAQHFTVGGSRVPGLNWGTSDVIGLDTTQGDLLEADPAGGYDVVSSSPTPWPSSTTPYVVAAEGGPDRVEARLPDGTVRELDIEEFVELVAADLAREALPPGTPVVLAVPFAADGYLDLPRRLADRTGRTVWAHSGRVTVESAPGEASTIDVVRTPKAPRGDWIASDPGLGPDADDSPGWHHEVVSRALVSALSGRQIGRASHHPAEFARDFEDDDRHLDRMATFVHDHPATGRTSGELDLPRPGPEDRAYRLDLHGSPGSLTFALRDGTTRDIDEREAGPWLRRRKSLTTLPEDHWVDLVVCWSGAPRDSAVPKPGTASDAYGGPFVADPLATVSMGQHVANATGRAVRLAYGPQGTRRSNGRYQRTLFADAQGRRRAWALASPEPDADELDRLAEIAGISPGDGEVSDEMRTATLRLVRALRITFGHDIDDDPGFDDLLRGAAAVDQMWRSDSDFEEAGPFTLDLLHRVVAAHPEAAAGVDRQTTRRVLAAAAEQWARYPGDGLVGFVDLPAVEAAAQWLAAGDAEDEAAAVLRLRTDEVGEAEMSRMFWARVKAEETLPGIGRDTQEFAARVLHREPDPGAAHARRTEALDVLTRAFAAGREASDPDIAAAYALKEAGAYDDTALDTVQGTSDGTGRDYTGGPAPDVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGZ9</accession>
    <name>A0A7K2ZGZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2620 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000974">
        <property type="protein sequence ID" value="MYW31626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021238">
        <property type="entry name" value="DUF2620"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10941">
        <property type="entry name" value="DUF2620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="11985" checksum="50C341C0CF790A6A" modified="2021-04-07" version="1">MTKILTGGVGKVEVTRAIDALGIDSLDVAASSDIDAAMKFRAGQADYYLGTCHTGAGASLGVLVGLMGSAVCHTFGRGVPDAAEIDALLADGKKVFGFSMDQIDTIAPLMARAIADHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH87</accession>
    <name>A0A7K2ZH87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GT040_21125</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000999">
        <property type="protein sequence ID" value="MYW31712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MYW31712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="30852" checksum="1CDA9600BF18E083" modified="2021-04-07" version="1">MPELPEVEALRVFLDDHLVGKEIARVLPLAISVLKTYDPPLTALDGTTVTSVARRGKFLDIEAGGLHLCTHLARAGWLRWKDSFPAAPPRPGKGPLALRLVTVDGDGFDLTEMGTKKSLSVHLVRDPMDVPGIAHLGPDPLADAFDRDTFAGIVGGARRQIKGALRDQTLIAGIGNAYSDEILHVAKMSPFKRTADLDEDDITRLYTALRTTLKDAVARSSGVEAGKLKSEKKSGMRVHGRTGEACPVCGDTILEVSFSDSSLQYCPTCQTGGKPLADRRLSKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHJ4</accession>
    <name>A0A7K2ZHJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001018">
        <property type="protein sequence ID" value="MYW31798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="347" mass="37915" checksum="6AC747F2E026D552" modified="2021-04-07" version="1">MAPVFAHGRLRLYLLKLLDEAPRHGYEVIRLLEERFQGLYAPSAGTVYPRLAKLEAEGLVTHATEGGRKVYSITDAGRAELAGRSGELADLELEISDSLAELAAEIRDDVRGAAGRLRSDMRAAASETRTDQGKQSSPFGDLGDFGDFGNLGDLTDSKAWRAAKEEARRAKEEWQEQARRAKDESRRAREEAQQARRQAKEAQDRAREQMRDAARQVQEHFARGEWPAGVREGLAEITGQLGGFARAGGWSSFGRPGPTETAEATETAEATEAHESASASGWGTDVPVTDDPARDLDRLLDRFRDTVRDTARDHGVTRDQVAEARGHLGAAAARIEALLTPEGDGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI11</accession>
    <name>A0A7K2ZI11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001063">
        <property type="protein sequence ID" value="MYW31984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="88" mass="9537" checksum="81B529A2AE618E94" modified="2021-04-07" version="1">RSRTLGEPTAHSAALTALAYRIHESFGLQRARVRGIALRAEGLADAGRASRQLTFDPADERSRRIEEVADRLRERFGPGAVKPAGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIF3</accession>
    <name>A0A7K2ZIF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF952 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001094">
        <property type="protein sequence ID" value="MYW32114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14980" checksum="4C98B5EE21D53086" modified="2021-04-07" version="1">MTEPLLHLAEAPLWEAARGTGTYEMSTRGRTLQEEGFIHLSLPHQLPGVARMLYGNGNGNGNVGGSEGERGVDDQDLVVLVIDPARLTAPLRYEAMKPGGEEFPHLYGPLPVDAVVEVRRLDDWHHDRREEDESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIG1</accession>
    <name>A0A7K2ZIG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cys-Gln thioester bond-forming surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_23485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001108">
        <property type="protein sequence ID" value="MYW32153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004629">
        <property type="term" value="F:phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023849">
        <property type="entry name" value="CHP03934_TQXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03934">
        <property type="entry name" value="TQXA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="TED" evidence="4">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="3">
        <location>
            <begin position="363"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="516" mass="52719" checksum="8ED4907B05D68D5A" modified="2021-04-07" version="1">MFSAPSVSASPSDAKAVHAVRGRTPRAGKASGTGRPRRGRAFLRPVTALLLSGLVTAATLAGTGTAAADDPGRHQGGAAAVLDGLKTFDSAVLRTPGENGAPDVTQELPAGLFEMTVDGGGKLKTYCVDLHNPTQNQAKYLETPWAETSLGANRNAGKIRWILQHSYPQVDDLAALAEAAGTGPLTERTAAAGTQVAIWRYSDGADVTAVDKQAEKLADWLHRRARNVTEPRASLRLEPAAVSGRAGGRLGPVTVRTDAEQVSVSPPVDAAVSGITVTDKKGTPVTSATDGARLYFSVPKGSADGSASLSVQTTTSVPVGRAFVGTTRTQTQILAGSSESTVSARATATWAETGAAPALTARKNCAAGGVDITAVNRGDEPFTFELGGAEHTVEAGATRTVTIPVAEDQAYDFTITGPAGFRKSFTGVLDCATSGSVIAAEKDQQADEDSGIGTRSARDSLPASTGTTTSGLEGDLAATGGSSTTPMIAALAVGFLVIGGGALFVLRRKEARQHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIK1</accession>
    <name>A0A7K2ZIK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001083">
        <property type="protein sequence ID" value="MYW32089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="5820" checksum="A7FA5B4A5BB35F3E" modified="2021-04-07" version="1">MNLLPKGTTPPEAAPVGTCMAPAPYAPVTKGGYAVAHAELPTPPPSPKGSTEPAAPSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIN9</accession>
    <name>A0A7K2ZIN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_23725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="30065" checksum="4853829A4031B9E3" modified="2021-04-07" version="1">MSTEQHDADAYGQELARISHHQHEATDARFMVFQALAAVGLSNEQADDVVAKLEAGAVAGAHTWISESSPPHGSEPRFEDGWFAGVRDVASYLLRIADTTANAGRGRAVSSAMLLAHLQQPHSPAPAEVLAEDPAPAPVPSVELDAKDVLAAAERFTWAVAAPGVRHWPDGSDFLDVALSTVCPEEREGYIERLEAFVEEHRPRLEEMLRTHGPGSKPASHGRYALIGQPETLVIVERMESAPFLLRGQWEKELETVFLDDLEFVWGPRIRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIX2</accession>
    <name>A0A7K2ZIX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_24190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001130">
        <property type="protein sequence ID" value="MYW32284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="195"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="433" mass="44057" checksum="13CC188A44973B65" modified="2021-04-07" version="1">ALNGLADACLKRQGRGAVRLNQDLSWGDGVAVPVPGPALPTPLPSDAREAAAAPAVEPPREFTGEDDRAIASCVGTARSEQLSSYVASPALLFIGDEGGATVPGFDLSPTNTAKIAGAAALVLALTVGASVLAGARLVRPLHALTGAAQRMRDGQEHASVPVSGDDEIGRLAAAFNDMSAHRARLEEQRKAMVSDVAHELRTPLSNIRGWLEAAQDGLADPDPAFVSSLLEEAVQLQHIIDDLQDLAAADAGVLRLHPEPVRVGELLSQVAAAHQARAETAGVTLTVEAGAVPILPADPVRLRQAVGNLVSNAVRHTPAGGRVTLRAYGSSGAGTGGSAGSGSESDAGQVAIEVADTGTGIPAGDLPYVFDRFWRAEKSRSRRTGGSGLGLAIVRKLAEAHGGTASATSTEGVGSAFTLRLPASGPDGMTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ46</accession>
    <name>A0A7K2ZJ46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MmcQ/YjbR family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001154">
        <property type="protein sequence ID" value="MYW32376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030563417.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001154.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="118" mass="13471" checksum="958F04617CE11310" modified="2021-04-07" version="1">MTPERLRAFCLEFNASVEEFPFGPETSVFKVLGKMFALTSLDARPLTVNLKCDPDEAIRLREEHPKAIVPGWHMNKRHWNTVTVSGIPDKLLRELIEDSYDLVVAGLPKAERLKLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ74</accession>
    <name>A0A7K2ZJ74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001156">
        <property type="protein sequence ID" value="MYW32391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="646" mass="64055" checksum="43C7598A524F3DA9" modified="2021-04-07" version="1">AGPKEAPDANAAARLALVAAVTEGDARDFGGHDLLGDLEKNVCASGPAPGCTAKGDFAGVSYGEGQALAVLALLRGGMVPPADTVTRLTQLVCEDGSVTSILIGPGENCDGDPMTTGLVALVLDEAGDHDATVARSVAYLKKAQLRSGAFPAFNGSTVGSVPATAYAAQALRALGQVRAADTAIWWLSREQLADGGFGSDEGAEEGGLYATAPALLAGSGTSLVTLTTKVPEPTEPPTTPPTTPPATTPPASGDGPDLKKGVAFLTSPANLRQGRYYTAGGSTGRADFGLTVDGAFALAATGHDNDALRGIVDFLDQGGKDGEARTVHDWTNVGSAHAMGGSMGKAALLAQAVERDPRDFGGKDLIAGLADAVCTAKSAAPDRSCADKGAYTYAMSVFGQSLGVIAQVRAGETKAAEAPISYLAGLQHTSSGAWPSLVPPTGDADVDSTAMAAMALDVVPGDAHAAAVDKALAWIASKQLKDGGFPGAAGNSVNSAALAVQGLSLDAEKYGKQIAKARKFLASQQNADGGFNVAKEGQRGSDLRASTQAVGGSTGISFGVLTRSLDGTTPNPLPSSSTTPVIVTPGDSTGGGGIVNTDGPGGGGGSLASTGGQALGLAGAAAALVLAGWGGVVAARHRRTTTGGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ99</accession>
    <name>A0A7K2ZJ99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001162">
        <property type="protein sequence ID" value="MYW32417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="565" mass="60623" checksum="F579775C427B6E9C" modified="2021-04-07" version="1">MPSSFDPATVAALLDGNPAGVAVLDANLRYTYVNPALERLNGLRAGAHIGHTFSEVLPELRGQAAVLRGVLRDGEPREQTISGRTWAASSAEPRFWRATYHRLETGGSVCGLMVIVVEISDVARQRAELEEARGHVALLSTAAVRIGTTLDMDTTCRELAEFVVPAFADVAAVDVFPPEVGHPVRRAEPGVLRLRRAALRGEGPLDEQVQRFGHPGEYVDFAADSAVTRCLAENEPVLDDWADHRRGRSAFTSDRIAASQALGLREALVVPLTARGRQIGSLSLVRADGSPAFTDQDVLVARELAGRAAVDLDHARRYDREHSIALELQGSLLSEPRGPHPHVEIATRYLPAERGVLVGGDWFDVVPLRDGRHLKAMGDVMGHGVEAAVAMSHYRSLLRLLAGDDLPPHLILEQLDAMVERSGLDRAATCLLAVVDRFGGVCEVASAGHLPPVFIDPGEAGARIVPVESGPPLGTGFGGYRTASVPCGPGTVLFMYTDGLVERRGEDIDVSVGRLASLTLPRTGTLEDLLDQVLDRFGGDAEDDIAVLASRIREGPPVLRRPDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJC7</accession>
    <name>A0A7K2ZJC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001153">
        <property type="protein sequence ID" value="MYW32359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515320.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001153.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="20163" checksum="526F5801AA1CBF93" modified="2021-04-07" version="1">MDDKDTPRVGAAVRRRRRTLGLTLAAVAERSGLSVPFLSQIENERARPSARSLDRVAEALETTTSRLRAAADSARAVDVVRGEEGDGVRRVVRGRHQLSALEFTGEQDLGREFQHRNDELMYVVEGAAEVEAEGQAYRLERGDTLFLSGGVRHRWRATRPGTRLLLVAVAEHIDATYDSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJJ3</accession>
    <name>A0A7K2ZJJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PQQ-binding-like beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001196">
        <property type="protein sequence ID" value="MYW32522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="318" mass="34396" checksum="554ACC3A2FF8AC23" modified="2021-04-07" version="1">MIASGDPLAALDGVTGAERWSLPGGAIPGAPLLLGNDTLYLASGKYDGSVIGYAPASGKETWRSHLGKEYRQPRPVAVDGTQVYVIAEILEADGSSRTNVIAALNSATGKLVWKEQRDLGTQQNGVHAAVQGRYLVYTDFKKNLTVRDTATGRQVWTQKTTKTSYGPFAVHQDLVIVPQGQKLQAFALADGSEKWSVTAERFTTFREPTVLDDVLCIADSGRTLWALDPRTGKKVWQSTALKDSGAQVPRQFVRVGSTLYGATDLDKQGGIHAFDAKNGALRWTFNDRSGDYHAWLVATDGKRVFALHGKKLHALPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJN6</accession>
    <name>A0A7K2ZJN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_25640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001198">
        <property type="protein sequence ID" value="MYW32562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="70" mass="7253" checksum="495A061C7003013C" modified="2021-04-07" version="1">MSPDAFHGLDDVGFSPAGQEVTYRVAEAVQGTDHQDLDETPEAVASTTKALAANAVHLARLLADAPHPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJS5</accession>
    <name>A0A7K2ZJS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cryptochrome/photolyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001201">
        <property type="protein sequence ID" value="MYW32595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007357">
        <property type="entry name" value="PhrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04244">
        <property type="entry name" value="DPRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="514" mass="58198" checksum="ADD74C8440681DA9" modified="2021-04-07" version="1">MAPRPHWLFGDQLGPHFLDPRHGGPDDKAPVVMIEARSVLRRRRFHRAKAHLVLSAMRHRAAELGDRVTYVRAETYTEGLEKVRGRRASSPLTVRHPTSRRALDFVGGLEGVEILPAKGFLVSHDDFAEWAGRNKGNGGKGSGQPPSLRLEGFYHWVRERHDLLMDGDHPAGGRWNLDHDNREPPPRGQDTLDVRGPWRPSEDDIDDEVRRDLDRWERDGDVSFVGRDGPRSFPATRREARTALRHFVAHRLAGFGRHEDAMLAADPVMSHSLLSVPLNLGLLDPAECVEPAEQAYRSGDAPLNSVEGFVRQIAGWREYVWHLYWHFGEDYRHRNALRHTTPLPDWFLDLDADAVTANCLSTVLAQVRDTGWTHHIPRLMVLGSRALQDGWDPAAVTDWFHRCFVDGYDWVMLPNVVGMSQYADGGMMTTKPYTSGGAYINKMSDFCAPCAYRPDHRTGEEACPYTAGYWSFLHRHRTRLAANHRTARAVKGLDRLKDLRELLDATAERGDAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJY0</accession>
    <name>A0A7K2ZJY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001209">
        <property type="protein sequence ID" value="MYW32641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561537.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001209.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="276"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="526" mass="56517" checksum="C21D8FC8A98642CF" modified="2021-04-07" version="1">MSEPQSDIHTTAGKLADLSRRIEEATHAGSARAVEKQHAKGKLTARERVDLLLDEGSFVELDEFARHRSTNFGIEKNRPYGDGVVTGYGTVDGRPVCVYSQDFTIFGGSLGEVYGEKIVKVMDFALKTGCPVIGINDGGGARIQEGVAALGLFAEIFRRNVHASGVIPQISLIVGPCAGGAVYSPAITDFTVMVDQTSHMFITGPDVIKTVTGEDVGFEELGGARTHNTTSGVAHHMAGDEKDAIEYVKSLLSYLPSNNLSEAPAFPEEADLAVTDEDRELDTLIPDSANQPYDMHTAIEHVLDDAEFLETQALFAPNIITGFGRVEGHPVGIVANQPMQFAGCLDIDASEKAARFVRTCDAFNVPVITFVDVPGFLPGVDQEYGGIIRRGAKLIYAYAEATVPLITVITRKAFGGAYDVMGSKHLGADLNVAWPTAQIAVMGAQGAVNILHRRTIAAAEDPDATRAELMTAYEDALLNPYVAAERGYVDAVIMPSDTRAHIVKGLRQLRTKRESLPPKKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK33</accession>
    <name>A0A7K2ZK33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001233">
        <property type="protein sequence ID" value="MYW32706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="100" mass="10469" checksum="7E434014CE889C89" modified="2021-04-07" version="1">RVWEPDFGDVSDDDVLDALEDEAGYAVGDPVVGRTGYLSPARAALVPEDLAAVRQELPGGGELLSIAAPGDSAAVVRAYERLREAGALAPLPRPMDRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK63</accession>
    <name>A0A7K2ZK63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate/guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_26035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001209">
        <property type="protein sequence ID" value="MYW32639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032026">
        <property type="entry name" value="Ad_Cy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16701">
        <property type="entry name" value="Ad_Cy_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="399" mass="43091" checksum="F27E1121C20AE50B" modified="2021-04-07" version="1">MTVGDTTSGAGEEPPSDSSVHATPHHEVDHTAEPTDDPLAIRLEALILGADRRYTPFQAARTAGVSMDLASRFWRAMGFADIGQAKALTEADVLALRRLAGLVEAGLLSEPMAIQVARSTGQTTARLAEWQIDSFLEGLTEPPEPGMTRTEVTYPLVELLLPELQEFLVYVWRRQLAAATGRVVQAADDDEMVDRRLAVGFADLVGFTRLTRRLEEEELGELVESFETTAADLVAAHGGRLIKTLGDEVLFAADDAGTAAEIALRLIEAMSQDETMPALRVGIAFGTVTTRMGDVFGTTVNLASRLTSIAPKDAVLVDGAFAKELVRHGEAPESEAQAAEEVAAAAERARLAEKEGREVVEEPPLPTYRFGLQPMWQRPVRGLGVVEPWLLARRGKTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKU1</accession>
    <name>A0A7K2ZKU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">GT040_27660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001297">
        <property type="protein sequence ID" value="MYW32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="307" mass="32942" checksum="87D2826E86D21416" modified="2021-04-07" version="1">MVHGGPELRSHTLLDDAVRARLTQVADLAPLHVPQALTVVDAARDLLPGVPHVACFDTVFHSGLTAAAREYAVPADWRHTYGLRRYGFHGLSYAWALARTAELLGRRPEQLHLVMVHLGGGCSACAVRDGRSVDTTMGFTPLEGLVMSRRSGSIDPGALTWLLTRKNLPANEIEDVLNRRSGLLALSGTSGDTRDLVRSRTAGDERAALALDVFTHQCRRGIAGMAASLSRLDALVFTGEIGEDQPEVREEVCAGLSVFGLTGGLRPLVAERPEIVSEPGARVPVVVIPTGEAQQIDVETRALLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL01</accession>
    <name>A0A7K2ZL01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional rhamnulose-1-phosphate aldolase/short-chain dehydrogenase</fullName>
            <ecNumber evidence="3">4.1.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rhaD</name>
        <name evidence="3" type="ORF">GT040_28110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.19" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001307">
        <property type="protein sequence ID" value="MYW33034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008994">
        <property type="term" value="F:rhamnulose-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013454">
        <property type="entry name" value="Bifunc_RhaD/ADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02632">
        <property type="entry name" value="RhaD_aldol-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="9"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="416" mass="44575" checksum="FD2B603A37D3BB5D" modified="2021-04-07" version="1" fragment="single">MALHSSAEALLARSHRLGSDPRNTNYAGGNASAKGAAPDPVTGHDVELLWVKGSGGDLGTLTADGLAVLRLDRLRALRDVYPGVEREDEMVAAFDHCLHGKGGAVPSIDTAMHGLVDAPHVDHLHPDSGIALACAADGEKLTADCFGDTVAWVPWRRPGFQLGLDIAAVKEANPQAIGCVLGGHGITAWGGTSEECEANALHIIRTAETFLAEHGRAEPFGTVIEGYGALPDADRRERAAALAPHIRALASRDRPQVGHFDDSPAVLDFLARAEHPRLAALGTSCPDHFLRTKVRPLVLDLPPTVELSGTVTRLNELHAAYREEYAAYYARHAEPGSPPMRGADPAVVLIPGVGMFSFGKDKQTARVAGEFYLNAINVMRGAEAVSAYAPIEEAEKFRIEYWELEEAKLRRLPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLE7</accession>
    <name>A0A7K2ZLE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_28785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001345">
        <property type="protein sequence ID" value="MYW33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="36" mass="3480" checksum="AD247E6380E2D9B0" modified="2021-04-07" version="1">MGLLMTGDFFSTFAKEGGRVGSGALGSGQGGVGRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLG7</accession>
    <name>A0A7K2ZLG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001350">
        <property type="protein sequence ID" value="MYW33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018510923.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001350.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="16089" checksum="0ADF87A0E67C63B3" modified="2021-04-07" version="1">MPDLIHDGDSAAAVSSLRSAVMLLGRRLKHQRVDESLSPTEMSVLGTLARCGSATPGELARKEHVQPPSMTRIVALLEAKGLVRLEPHPDDRRQKRVSQTEQAEAMLAESRTKRNAWLAQLAEGLDEDEWETLRAAAPVLEKLAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLQ4</accession>
    <name>A0A7K2ZLQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001365">
        <property type="protein sequence ID" value="MYW33287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="88" mass="9443" checksum="ED6EF64C4BCA4D49" modified="2021-04-07" version="1">HTLAYDDALLGDGAIPAERFAAVTARTLVVCGGFSSARARASTRTLTEALPRARHRTLTGQMREAAPQVLAPVLADFFARDVYVRQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLY9</accession>
    <name>A0A7K2ZLY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="12" type="ORF">GT040_29670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="WWKE01001372">
        <property type="protein sequence ID" value="MYW33320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW33320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="217" mass="23622" checksum="C94264B9507C9D91" modified="2021-04-07" version="1">MPELVFFSGTMDCGKSTLALQIGHNRSARGLQGVIFTRDDRAGEGKLSSRLGLVTDAVEADEGMDVYAHIVDRVSRGGRVDYVIVDEAQFLAPVQIDQLARVVDDLGLDVFAFGITTDFRTKLFPGSQRLIELADRIEALQVEALCWCGARATHNARTVDGEMVVEGAQVVVGDVNRQAGEVGYEVLCRRHHRRRLTAETARAGTLSPDVLPVAAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLZ8</accession>
    <name>A0A7K2ZLZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001365">
        <property type="protein sequence ID" value="MYW33289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="90"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="27683" checksum="E410608FA9F9F384" modified="2021-04-07" version="1">MGNNGSTGASGKPSGTSSRRASRQKPSGGVSRRALLIGGGGVVAAGTVALLARDEVKRAWWRVPGVEKPRKPGELDYGGATWVAASEANWRRADRPDDFRIDRVIIHVTQGSFDSAVRVFQDPAHRAATHYIVGQDGRVVQMIRELDVAYQAGNRSFNERAVGIEHEGFVDRPKDLTKAMYESSARLTASICARYDIPIDREHIIGHVEVPGTDHTDPGPHWDWDRYLKLVKRAATAPPSPTPSASPSASATRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM72</accession>
    <name>A0A7K2ZM72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system PemK/MazF family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001398">
        <property type="protein sequence ID" value="MYW33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="155" mass="17311" checksum="C7B4EC7BF7A4F54B" modified="2021-04-07" version="1">MTFHHSAQRTDSPPVPPGSTGPTATVQADPREVGPVRTSYAPDRDGDPDPGEIVWTWVPFEEMDGRGKDRPVLVVAREAPGTLLAVQLSSKQHDMDHEWVALGAGPWDSSGRQSWVDLDRVLRVHENGMRREACALDRDRFDSVVGRLRERYGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMB5</accession>
    <name>A0A7K2ZMB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_30545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001406">
        <property type="protein sequence ID" value="MYW33491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="126" mass="13379" checksum="231AD6C56C63C2DA" modified="2021-04-07" version="1">REVLETGAAGLCADGLADGGAARLRAALEATQGARLEDYRRQDTLLHLTLAELSGSRSLAAQYASVRATLNELLDCIPLLVRNLEHSQQQHAAVVEAVLDGDADAAREMMREHCAGTAALLRGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMN2</accession>
    <name>A0A7K2ZMN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_30920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 6">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001434">
        <property type="protein sequence ID" value="MYW33558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="7">
        <location>
            <begin position="220"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="463" mass="49968" checksum="9189AA7DF6F2E8B2" modified="2021-04-07" version="1">MPLTPDSARDSVHAHDAANRVIEPLYAEILRRNQGEQEFHQAVREVLETLGPVLTQRPEFVDARIIERICEPERQLIFRVPWADDSGDIHVNRGFRVEFSSSLGPYKGGLRFHPSVNLGIVKFLGFEQIFKNALTGMPIGGGKGGADFDPKGRSDAEIMRFCQSFMTELHRHLGEYTDVPAGDIGVGGREIGYLFGQYKRITNRYESGVLTGKGLGWGGAQARTEATGYGTVLFTAEMLRSRGESLEGQTVAVSGSGNVAVYAIEKAQQLGATVITCSDSGGYVVDEKGIDLALLKEIKEAGRGRVSEYAERRGAHARFVAGTGVWSVPVDVALPCATQNELHEADALELVRNGVKAVAEGANMPTTPEAVHVFQQAGIAFAPGKAANAGGVATSALEMQQNASRDSWTFSHTEERLAEIMRHIHDSCYTTAERYGSPGNYVVGANIAGFELVADAMLAQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMR3</accession>
    <name>A0A7K2ZMR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SCO1664 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001437">
        <property type="protein sequence ID" value="MYW33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022292">
        <property type="entry name" value="CHP03843"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03843">
        <property type="entry name" value="TIGR03843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="29454" checksum="014DEFDE657B7469" modified="2021-04-07" version="1">MPAPERIPSRSLTDTEVLTLLAEGTLTVLGQVGGASNAVLHCTVAYEGEERTCAYKPVAGEQPLWDFPDGTLAQREVAAYEISRATGWDLVPPTVLRDGPYGQGMCQLWIDAPEEDPPELLALVEDDEPGEGWKAVGLADVGGGRTALLVHADDPRLRRLAVLDAVINNGDRKGGHLLPSPGGLLYGIDHGVTFNADDKLRTLLWGWAGEPLTEEALRVLGLLAGELAAGEPLATRMAQLITAAEVEALRERVAGLLGSGVHPKPSGQWPPIPWPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMT6</accession>
    <name>A0A7K2ZMT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_31515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001441">
        <property type="protein sequence ID" value="MYW33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="33993" checksum="394D1097FE0E2BBF" modified="2021-04-07" version="1">MSTELAIETTGLVKVFGENRAVDGVDLAVPTGTVYGVLGPNGAGKTTTVRMLATLLRPDGGSARVFGKDVVKEADAVRSRVSLTGQYASVDEDLTGTENLILLARLLGHSKPAARDRAAQLLEGFGLSEAAGKQVKNYSGGMRRRIDIAASILNTPDLLFLDEPTTGLDPRSRNQVWDIVRAVVAHGTTVLLTTQYLDEADQLASRIAVIDHGRVIAEGTKGELKASVGSGTVHLRLREAAQRPEAERVLSLALDATVQLDADPVALTARVDAHGSDRGAAEQAARALAELARSGITVDNFSLGQPSLDEVFLALTDKKGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMZ0</accession>
    <name>A0A7K2ZMZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_31335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001437">
        <property type="protein sequence ID" value="MYW33639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030570186.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001437.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="68"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="27304" checksum="2DD47BE276252A7B" modified="2021-04-07" version="1">MAKNIQSLERAAAMLRLLAGGERRLGLSDIASSLGLAKGTAHGILRTLQLEGFVEQDATSGRYQLGAELLRLGNSYLDVHELRARALVWTDDLARSSGESVHLGVLHQHGVLIVHHVFRPDDSRQVLEVGAMQPLHSTALGKVLSAYDPVAHSEVMEAERRSFTGRTVTAADEFEAMLDLIRAQGWAADAEETWEGVAAVSAPIHDRRRMPVGAVAVTGAVERVAPGGVLRPELIAAVRDCARAVSRDLGAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNF8</accession>
    <name>A0A7K2ZNF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NfeD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_32715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001493">
        <property type="protein sequence ID" value="MYW33904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="143" mass="14631" checksum="1BE8FDFC33B7DB6C" modified="2021-04-07" version="1">MDIDAWVWWLIIAAGLGIPLVLTAMPELGMFAVGALAASVVAALGGGIVAQVLVFVGVSVALLVVVRPIAARHRAGQTGHASGIDALKGRQAVVLERVSADGGGRIKLAGEVWSARSLDEGQVFEPGRQVDVVDIDGATAVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNK7</accession>
    <name>A0A7K2ZNK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001502">
        <property type="protein sequence ID" value="MYW33954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="16524" checksum="0B2AB3AF69AF5F24" modified="2021-04-07" version="1">MVSTDWKTDLRQRGYRLTPQRQLVLEAVGALEHATPDSILCEVRKTASGVNISTVYRTLELLEELGLVSHAHLGHGAPTYHLADRHHHIHLVCRDCEGVIEADVSVVTEFTEKLRADFGFATDMKHFAIFGRCEACSAARDGAGTGEPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNQ2</accession>
    <name>A0A7K2ZNQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase</fullName>
            <ecNumber evidence="1">1.1.1.333</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.333" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001505">
        <property type="protein sequence ID" value="MYW33970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="26190" checksum="CB95FEBD8DCE7FB7" modified="2021-04-07" version="1">MKDAFGAPQSLLVLGGTSEIALATARRLIALRTRRVWLAGRPSPALDAAAVELRDRGADVRAVAFDALDPGTHEEVLGKVFAEGDIDVVLMAFGIAGDQARDEEEPLAAVRVAQTNYTGAVSAGLVCAGALQAQGHGSLVVLSSVAGERARRADFIYGSSKAGLDTFAQGLGDALQGTGVQVMVVRPGPVRTRASAGQPEQPLSTTPEAVAGAIVTGLRRRSETVWVPGSLRVVMSALRHAPRPLFRRLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP78</accession>
    <name>A0A7K2ZP78_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase GT040_34080</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_34080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001552">
        <property type="protein sequence ID" value="MYW34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="416" mass="45414" checksum="1A931CD3092F49D9" modified="2021-04-07" version="1">MSLDVRTVTASDYPDWLRAVQNGFLTAGSPSEDDAAERLADTDLSRIQGAFEAGRCVATFRSFAQRLTVVGGATVPADAISGVTVAPTHRRRGLLSRMMATDLAAARERGEVVATLIAAEYPIYGRFGFGPAAWTTEWEVSVHRAGLDPRRSGQPADGGRIEMVDGADIRKYGPELHTRLAALRPGVVSRSERWWKRHTGAVTLPAHEKWTEPFYVIHRDADGEVDGLMVYGTDDKWGDAKQPLNTATVRDLIALNPAAERALWLFLCSVDWVTTVRSGYRAPDDLLPLLLPDPRAARTVSHADWLWLRLLDVERALEARGYEREASLVLDVRDGGGVAEGRFLLDVSPDGARCVPTTRSADLALGAGELAALYLGDESARRLVDLGRAEELRTGAAGTADAVFRTGRRPWCPDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPC2</accession>
    <name>A0A7K2ZPC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">GT040_34195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="WWKE01001557">
        <property type="protein sequence ID" value="MYW34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514123.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001557.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="18640" checksum="B60B4D660E09519F" modified="2021-04-07" version="1">MTDVRADLLQQIKDKAVVHGKVTLSSGLEADWYIDLRRITLDGKAAPLVGQAMLDATAELDYDCVGGLTLGADPVATSMLHASAARGKSLDAFVVRKAQKAHGMQRRIEGTDVKGRRCLVVEDTSTTGGSPLTAVEAVREAGGEVVAVAVIVERGAAPAIAEAGLPYVQVYSVADLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPE8</accession>
    <name>A0A7K2ZPE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001571">
        <property type="protein sequence ID" value="MYW34222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="2">
        <location>
            <begin position="66"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="24271" checksum="31BDC8FF1D69F436" modified="2021-04-07" version="1" fragment="single">LLPAADASGGVLWFLVDAGAEGLTVRPHRSVDPTRPTAEVRADAVLVPAHRTLPLDSGLVRDLAAVLLAADACGTAARSLDTAAEHARVREQFGRPIGAFQAVKHLCADMLVRLEQARALTWDAARAADEETDTSGDGEARGLTAALAAATAPEAAYSCAKDAIQILGGIGFTWEHDAHLQLRRAVLARQLLGAPDTHRLRAARLAEAGARRELSLELPAEAARHRADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPE9</accession>
    <name>A0A7K2ZPE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G/U mismatch-specific DNA glycosylase</fullName>
            <ecNumber evidence="2">3.2.2.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.28" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001584">
        <property type="protein sequence ID" value="MYW34244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000700">
        <property type="term" value="F:mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="15"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="19867" checksum="940CD57F2FEC433B" modified="2021-04-07" version="1">MTPEELRAARDRIVPDVAAGGLRVLFCGINPSLMTAATGHHFAHPGNRFWPVLHRSGFTPRQLLPAEQSELLPLGLGITNVVARATARADELGAEEFRKGGAALTERVERLAPAWLAVVGITAYRTAFGEPRARIGRQERTIGGAHVWALPNPSGLNAHWTIDTMAEEYARLRAAVPASAPNSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPH8</accession>
    <name>A0A7K2ZPH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001586">
        <property type="protein sequence ID" value="MYW34266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="180" mass="18810" checksum="2B9CDA77DA7AEC51" modified="2021-04-07" version="1">MRAVPPVLLALRRFPNPRLTGIGAGLFAALTMLVLACLDRLLFDSSELVYGLLFLPVSALTALWVRPADLVTAPISVPIAFAVGVFPISGGSEGFGGQVMALVTALAVHAGWLYGGTLIAGLIASVRKVLHMRARQRYLLAQGRTGGAEKAPRPAPRAPKKKVAGAGAPAGRAERPRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPR1</accession>
    <name>A0A7K2ZPR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001594">
        <property type="protein sequence ID" value="MYW34332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="455" mass="50702" checksum="3DC53FA13EF8537A" modified="2021-04-07" version="1">MSTQTGPALDTPSRGHAFVAGPKGLPLLGNLPQFGKNPLAFFELLRGRGDMVRWRFGRNRCVFISDPDCIGELLTETERTFDQPALGVAFRAVLGNGLIVARGRDWRRKRSLVQPSVRPKQVKSYAATMASSAVELADTWSDGERVDVKQEMAALTQKIAVRTIFGVDTPADSEAMGRAMDVAQMEIGKEFAGIGALLPDWVPTPGRARIKKAAAVIDSEVGRVVARHRDGETERPDLLSRLLTAVDESGERLSDEEIRDETVTLYIGGHETTSSTLVWAWYLLSRNPRVRAALTEELDRVLGDREPGFEDYAQLTYTQAVVKETLRLYPTIWLITGVAKEGARLGGMPIEEGTRVWSSQWSTHRDARWFREPEEFRPERWDPEDGDEIAEYAWFPFGGGPRVCLGTRFAMVESVLILAVLARRFELDVEPGVVEPVPSLTLQPDRDVRATVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ06</accession>
    <name>A0A7K2ZQ06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001598">
        <property type="protein sequence ID" value="MYW34349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="35127" checksum="D8170E2BE4E722B4" modified="2021-04-07" version="1">MFTLPLGDRAQLSPLEPSQAPEFLAHIDRARATVDAWLPWASLSTDLASATATLQGFADRRAADGARIHGIRLDGTLVGGALFTSFDAAPGVGEVGCWLERAGEGQGLATRACRALIDRAFSRHGMSRVEGRAASGNAPGIALARRLGMRRDGVLRRHSVHRGERRDIEVWSVLADEWPATDGTSGAAVRAELDRLMGVFVGAFTNTGGRRPDLGVLRDVFVPEGRIIANVGDEPVIHDLDGFIAPRQKMLTDGTLTEFSEWEVAERTEVFGSVAHRFSEYRKSGYHRGEWFEGGGHKTTQFLRTPAGWRMSSLAWDDAPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ38</accession>
    <name>A0A7K2ZQ38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secG</name>
        <name evidence="11" type="ORF">GT040_35765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001628">
        <property type="protein sequence ID" value="MYW34491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241503.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001628.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW34491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8167" checksum="BAC036A4C778BC9C" modified="2021-04-07" version="1">MVMAFQIALIVFSLLLMLLVLMHKGKGGGLSDMFGGGMQSSVGGSSVAERNLDRITVVVGLVWFACVVVLGLLVKLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ91</accession>
    <name>A0A7K2ZQ91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001629">
        <property type="protein sequence ID" value="MYW34502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073878323.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001629.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="22719" checksum="8B7F6C2500CBBF05" modified="2021-04-07" version="1">MTAPEGRGIAGRTDTFRILHVSTGNVCRSPITERLTRHALVGRLGDPLSGGLIVESAGTWGHEGAPMEANAEVVLADFGADASGFVGRELLDEHVIRADLVLTATRDHRAQVISMGHSAGLRTFTLKEFTRLVRAIDPATLPDPLDEGVVERARALVRAAAALRGWLLAPTAEADEVYDPYGAPITFFRSIGDEINQALDPVVTALTGVRAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQJ3</accession>
    <name>A0A7K2ZQJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001652">
        <property type="protein sequence ID" value="MYW34612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046039">
        <property type="entry name" value="DUF5997"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19460">
        <property type="entry name" value="DUF5997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="130" mass="14198" checksum="F698A5FD3927F8D6" modified="2021-04-07" version="1">MTSHKTAQTMKPATAAKKLGVYLQATPAEFQEGAVSRTELNALQTDPPAWLVELRRTGPHPRPVVASKLGISIAGLARGGITDALTTEQVDALKDEMPEWLQKERATQAEVRKEAARIKERNAERAARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRA0</accession>
    <name>A0A7K2ZRA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <shortName evidence="3">ADI</shortName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arginine dihydrolase</fullName>
            <shortName evidence="3">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arcA</name>
        <name evidence="5" type="ORF">GT040_37915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arginine deiminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001723">
        <property type="protein sequence ID" value="MYW34904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3 4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="410" mass="45894" checksum="6B9EB48AA015D9D2" modified="2021-04-07" version="1">MGFHVDSEAGRLRRVILHRPDLELKRLTPSNKDALLFDDVLWVRRARQEHDGFADVLRDRGVEVHLFGDLLQESLDIPVARRLVLDRVFDEKEYGPLATEHLRAAFEELPSAELAEALVGGMTKREFLERHSEPTSVRFHVMDLDDFLLGPLPNHLFTRDTSAWIYDGVSINAMRWPARQRETVHFEAIYRHHPLFTGPEAGVFHHWSEGQDDYPSTIEGGDVLVIGQGAVLIGMSERTTPQAVEMLARGLFDAGSARTIVALDMPKARAFMHLDTVMTMVDGDTFTQYAGLGMLRSYTIEPGSGPRELKVTDHPPEHMHRAIAAALGLDSIRVLTATQDVHAAEREQWDDGCNVLAVEPGVVIAYERNATTNTYLRKQGLEVIEIRGSELGRGRGGPRCMSCPVVRDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRL6</accession>
    <name>A0A7K2ZRL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001757">
        <property type="protein sequence ID" value="MYW35040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="12591" checksum="2E17ECE4E1A18195" modified="2021-04-07" version="1">MERELLERLLVGNDEASVAALAALRCGGSYEVWDGTTSAEPLALAYGRRLRHTRRRGIETVNLERAVELLGRHQQPVRLGQIRAADGSWIFMLFLTEDNSGVIACTGVRRTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRR6</accession>
    <name>A0A7K2ZRR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-ribosomal peptide synthetase condensation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_38525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001747">
        <property type="protein sequence ID" value="MYW35022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="69"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="27224" checksum="76C02AC26ABF40E4" modified="2021-04-07" version="1" fragment="single">MTEPVVVDAEGGAGEGSSADAVTGIVTAAAPDAARASGPDAVTASGPAGRTVTEETVTVAFGGGRDGRAPLTWGQRAIWHAIRRTAPNDHYFNIGRVLPLADRGRPATVVDAARSLGVLMERHEALRTRLELPADDRGAATGQRLAATGRLPVTLAHARDPADAERTAHALLDRLSATRFAYTSEWPVRAALVAVGDRVTHAVLVLCHLAADGHGAEVLVRDLRLLVRRGSAGRPPAATPLDLAREQHGEMGRRRGAAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRT7</accession>
    <name>A0A7K2ZRT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_38950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001773">
        <property type="protein sequence ID" value="MYW35100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="424" mass="44696" checksum="CDC0E0ED1755C3CF" modified="2021-04-07" version="1">MTETSEPPVHRTRIFADLTPLRSSPDYRRLWFGNTVSWIGQGMTALAVSLQVYDITGSAFSVGLIGFCSLVPLVVFGLYGGAVADTFDRRKLGLFSAAGSFSLALVLMAATFAGIENVGLLYAIVALQAVCFALNAPARSSMVARLLPPEQLPAANALSSMTSTTGALVGPMLGGLIVGWWGYRAAYTVDAVTFTASLYAMWRLPSMLPDREDREGSGARKRASVLDGLRFLGGRPNLRMTFLTDLCAMVLAHPRALFPVVAIVWYGGDARTTGMLVAAPALGALLGGVFSGWLGRVRLHGLAVLLAVGSWGAAIAVFGLTRHLWLGLLFLALAGCADTVSMVFRNTMLQAAVPDEMRGRLQGVFIVVVAGGPRLGDFLAGSVADLTSPAVAVVGGGVACVVAVSLLALKWRGFARYDARDPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS35</accession>
    <name>A0A7K2ZS35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_39350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001784">
        <property type="protein sequence ID" value="MYW35176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW35176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="294" mass="32185" checksum="B1674F53DE4210A7" modified="2021-04-07" version="1">MTADPATDVFEEHRPVLTGVAYRMLGRVADAEDVVQEAWLRWSSAAQEDVREPRAFLVRITTRLAIDRLRHLKSRREAYVGPWLPEPVVTDFGPAVPDAAERAVLADSVSLAVLVVLESLSPLERAVFVLREAFGFPYAEIATALDRTEAAVRQLAGRARRHVDERKPRYDVDPGERRDLTERFLAAASGGSIEQLMALLAPDVRLVSDAGGKAKVARRVIEAADKVGRFLAAVGQEVGPDWDMRVAEFNGGPAVACFVGGKPDTFFQVEVRDGAIQCIYIVRNPDKLAGLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS99</accession>
    <name>A0A7K2ZS99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinone biosynthesis decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022390">
        <property type="entry name" value="HBDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03701">
        <property type="entry name" value="mena_SCO4490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="53568" checksum="3A2B8CF9E8B73572" modified="2021-04-07" version="1">MAYDDLRSLLRALERDGDLKRVKAEVDPHLEVGEIVDRVNKAGGPALLFENVKGSSMPLAMNVFGTDRRLLKALGLKSYSDISDKIGGLLKPELPQGFVGVREAFGKLGSMVHVPPKKVKSDDAPVQEVVLKGDEVDLDQLPALFTWPGDGGSFFNLGLTHTKHPETGVRNLGLYRLQRHDKRTIGMHWQIHKDSANHYQVAARRGERLPVAIAFGAPPAVTYASTAPLPGDIDEYLFAGFVQGKRIEMVDCKTVPLQVPAQAEVVIEGWLEPGEMLPEGPFGDHTGFYTPQEPFPALTIDCVTMQKRPLLQSIVVGRPPTEDGPLGRATERFFLPLLKIIVPDIVDYHLPEAGGFHNCAIVSIDKKYPKHAQKVMSAIWGAHMMSLTKLIVVVDSDCDVHDLHEVAWRALGNTDYARDLTVTEGPVDHLDHASYQQFWGGKAGIDATRKLPTEGYTRDGGWPEMVESDPETAAKVDRRWKEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSC0</accession>
    <name>A0A7K2ZSC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001829">
        <property type="protein sequence ID" value="MYW35281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="23927" checksum="AAFB36A7A9207004" modified="2021-04-07" version="1">MAQLLRVQNFTVSSDGIAAGEDQTLERPFGHVEPERLFSWAGATASWPMRTDPGGSRGLDDYFTRDFDRNIGAEIMGRNKFGPQRGPWPDDAWRGWWGDKPPFRTPVFVMTHHERPSFTLSDTTFHFVGGDPADVLAQAREAAQGKDVRLGGGVTTIREFLDADLVDTMHVVVSPVKLGTGLRLWDSPDELLDRFHLEAVPSASGVTHHLFWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSV3</accession>
    <name>A0A7K2ZSV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001840">
        <property type="protein sequence ID" value="MYW35377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="35834" checksum="F9B27307AF45D1BD" modified="2021-04-07" version="1">MNSDAKILLLYVQGLPDSATDHPLGELARKLDMKGRSYQQAKKQLTEHGYLHEWRSQGDGGRWMTEQLLSSTPLTRDEAGTARAKLSPEKGQLTRPEQPPCPPPGAQLPTVGEPTSRPVGGYEPEEEHDEKNNPPDQPTEPAASKSAPEPEPAGDLDGEAPLPSPQLWRAERVLLSLRHSRRELLLGVGEARVLAGRAARWLERGVTESDLRHALLAELPKEGVRSAFGFLGHRLTHKCPVPPAPAAPPQPPPPPVRALIACTGTGTGAEEHLFRPLGDETECAECRRATAYASWMVDTDTYDFPPDMTWRQRIVAVAKADALRGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6G8</accession>
    <name>A0A7K2Z6G8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000058">
        <property type="protein sequence ID" value="MYW27944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="98"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="701"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="901" mass="97367" checksum="67AAA78E587917B5" modified="2021-04-07" version="1">MTDLLTAVRAGQHREVPALVLRLDLAARRAALAELKELRKEARGWEWQRQDKIRKALQVAGAGCHTGAAGCATWIGGRDLRSWSRSPYPLILVALGDRDPAWLGDLAHRLAAKSLNSEAEYTFISELVRTAGCPIPTTDSLVEGWAERISTARWHGRSGRRVPLVDLLRSDPHVAVLAPRLFEMRELPSQVGWYDTPDSTDHWPAALRVLAEEGVLDRPQLAERCVTRLVRGGKTGDQRFFLTVLQQLSITEDEERDRLRDWMAMAGDGISVVASHAQDMLARLDARGELSTGDLAEVSGSVLFRREKKLVRGQLILLGKVLSRDASTAGELLPVVAETFGNEDVALQERALKLIARHLPADDAPLREELAFAAAQLGPLHREAVTALFGAVGEEASADGPYEELLPPVPVLSRLDPAPGSVAELVEEVAAQLKSRSWQGSTPGALAAASGISAFERTLDGLVRVARTDRAELTEALREALAGVWFVEHGFGQLPEPAYMTTDYALALVVGSLLGRVPYQDVVEGKNRWTGTGTCAHAALNGVLLARAWEAAGDVVTDRVPFLLATPAWHTGSLDAAELVERLRTYQRLGVAPGPADFSQALLRVRRTGASVAAEAAASLSTPEGDRLAAWIRADEPVAPVLRHGLTSDRPSAGNWWQRSASGVRQVLLATRERLVIQQEFPRSFHWLGRPHVPNTRECYHWGTDQCPHWAATLPEDGETLAAWLMPDLLRTADEGPRGGAWFLPPLMETGGEAGVAVHLALAYGLGARHPEDRISAVDALLVLASQGRLDTTLLGRELGVLIDHDLVKVNRLADAARTAAATGAYRTVLGVLARALPTLLAYEKAPRGLGDLLAVAAECAERCGTEGIEPIAGLAATAGRKGSSQTVRQAARLEKTFTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6K7</accession>
    <name>A0A7K2Z6K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000063">
        <property type="protein sequence ID" value="MYW27976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="426" mass="42643" checksum="D7906AF0D61A9C6C" modified="2021-04-07" version="1">MTIAATRPGAAPVPPGGAPNGTPPGGRPSRALTAVYVAGAATALGTQMTMLALPWLVLETTGSATRAGLVFAAQVLPMALLGFVGGEVIQRLGACRTMVVSDLARAPVVALIPLLQTLGALNLAVLVVIVAALGALAVPYHAAQRVLAMELLSPHARSLARANSALEGVQQGSAFVGPALAGALIPLVGTTTVVWLDAATFAFSGLLLLRRVPAGCGGAGRSAAGPRGLWAGVRHLCGDWFLSRAMLSTVVFGLMLRTLMITMPVLAFVRFEGDARVGGLLIAALGAGGLVGSVTAYVLAERVAPVRLACTALVGVALPLWTLLVPVPAGVLVVAVGLSSAAAPLANAPLMGLLSARLPDGFGPKVLQAVVTISTLAGPLGFLAAGAVLDRAGIAATLWGVAALATFGSGNLILALRRLQATGDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6M2</accession>
    <name>A0A7K2Z6M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_01585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000067">
        <property type="protein sequence ID" value="MYW27997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="19"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="479" mass="51506" checksum="EDB2DA968BA4F0B7" modified="2021-04-07" version="1">MTTEVRRLRNYINGEFRDAADGRTIDVVSPVTEEVYATSPLSGQADVDAAMEAAAAAFPAWRDTTPAERQKALLKIADAFEERAEDLIAAESENTGKPIGLTRSEEIPPMVDQIRFFAGAARLLEGRSAGEYMEGLTSIVRREPVGVCAQVAPWNYPMMMAVWKFAPALAAGNTVVIKPSDTTPASTVLMAEIMGQILPKGVFNVLCGDRDTGRAMVEHPTPAMASITGSVRAGIQVAESAAKDVKRVHLELGGKAPVVVFDDADIAKTVSGVSEAGFFNAGQDCTAATRVLVHESIHDEFVTALAKAAADTKTGQPDDEDVAYGPLNNANQLGQVSGFIERLPAHAKVEAGGHRVGDKGYFYAPTVVSGLKQDDEIIQNEVFGPVITVQSFTDEKQAVEYANGVDYALASSVWTTNHSRAMRMSKNLDFGCVWINTHIPLVAEMPHGGFKKSGYGKDLSAYGFEDYTRVKHVMTSIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6P3</accession>
    <name>A0A7K2Z6P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_01690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000070">
        <property type="protein sequence ID" value="MYW28016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="22205" checksum="4CEFF447F15BA420" modified="2021-04-07" version="1">MAFGRSSRVKQRPVEPVTLKILVAGGFGVGKTTAVGAVSEIRPLRTEERLSEAGRPVDDLEGVEAKTTTTVAMDFGRITVREDLVLYLFGTPGQDRFWFLWDELAQGALGAVVLADTRRLEDCFAAVDYFERRRIPFTVAVNCFEGAGQFPAETVQAALDLDPEVPVLLCDARDRSSVRDVLIAVVEHALERAARDRRPVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Q9</accession>
    <name>A0A7K2Z6Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_01770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000075">
        <property type="protein sequence ID" value="MYW28030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1061"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="969"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="1096"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1098" mass="117299" checksum="34CEF41903FDBDF0" modified="2021-04-07" version="1" fragment="single">MSSSSTDQYPGDTEAGDGPGAGPSLAPGRSGGASLSEAKRALLAQRLKGRARAVQAVPRRPEDTAPPLSFAQERLWFMEQFAPGTAAYNIPVARRLRGPLDRPALQRALDAVVARHETLRTRYPATDDGRPVLEIADPAPFGLRTADADDEEHAARLVDDLGALPFDLVTGPLMHGLLVRVADDDHVLLLVVHHSVSDGWSSEVLVSEVLRGYAAYTSGGGDPLPELAVQYGDFALWQRERLTGGRLEQEVAYWARELAGVRPLELPTDRPRPERQTFEGAGYGFDIDRELLERLTALGKEHGATVHMVLLAAFQVVLSRFAGQRDFAVGSPVAGRPEPELEGLVGMFVNVLALRARLDGDPSFAGLLGRTRETCLEAYAHQELPFAQLVSELNVERDVSRSPVFQAVLAIQNYASAAEATAGAELPLEIEPFGLHAAGTRFDLELFLMEWPGGLRGAFNYNTDLFDESSVARIAAHLGRLLRGVADSPDVPLSAHDGLDPAERHRMLTEWNDTAFEAPEAPGDGTLTALVAAQSARTPDAVAVEFGGDSLTYAELDRAADRIARRLAGAGAGPGTLVAVSAERSLGLVAGLLGVLRTGAGYTPLDPEYPAGRLAFMLADSGAGILLTQAGLPVPEGCAARVLLIDEEAAEEPLHEGELSAPDVDDIAYTIYTSGSTGRPKGVPNTHRAIVNRLRWMARRYGIGPGDALLQKTPTGFDVSVWELFLPLITGARLVVAQPGGHKDAAHLRDTIAQYGVTVAHFVPAMLDVFLAEEDIERCVSLRRVVCSGEELAPHTARAFTARLPACALANLYGPTEAAVDVTSWECEGELATVPIGAPVDNTRLYVLDAELRPLPPGTPGELHIGGVQVSVGYHRRPGLTAARYVPDPFGPPGSRLYRTGDLARWREDGQLEHLGRIDQQVKIRGQRIEPGEIEAALLDEPEVAAAAVIVREDTPGDKRLVAYLVPAEPPAPTGAGETPVTGEAPVTGGHGLQEPGAGEPEPWEPDPAALRTALRRTLPDYMVPAAFVALEALPLSPNGKLDRRALPAPQARRTGGALAAPETETQRVLAEVWAEILTLPEVGVDDDFFDLGGHSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6S6</accession>
    <name>A0A7K2Z6S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000080">
        <property type="protein sequence ID" value="MYW28047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="434" mass="46079" checksum="FA09943C77B3A47A" modified="2021-04-07" version="1" fragment="single">MRATSPVIVGRDEEIGLLSSALDAVQRRSGRALFFVGEAGIGKSRLVGEAAYRAYGLGMPVLRGRATSTGLVVPFRPLVEALSSRFRAAGTPTDPELAPYHPALARLVPEWRQEASPGYPETVVELAEALLRLLSVLGRESGCAILLEDLHDSDTETVAVVEYVIDNLADLPILLLGTLRPEAGAALDLVRSAERRQAASVRELKPLADEQMRTLTAACLEAAPEEIPPVVHHRLAERAGGNPYLVEVLLADLLDTGQLRRSGSGWEAAEQPGGPVPSGIVRTWTRRLDRLDEPVRDLLLAAATLGGQFSVSVLQTVTGFEDRALFTHLRSAVEAGVIAPDGAAPDRYAFRHSLTAEALISSLAPAERASLARRAAGAIEHSGHPLDEDGQQLVASLHLAAGNRAGAALRFAEAGRRMLASGAHGSAVVLLERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6T9</accession>
    <name>A0A7K2Z6T9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_01730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000072">
        <property type="protein sequence ID" value="MYW28023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="56"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW28023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="149" mass="14594" checksum="320B25BCD02CF313" modified="2021-04-07" version="1">MSAVQERRTLLERRTVVLAVGAAGATAALTACGGSDGPGGAESVEQQPGSGGAGGAVLAKTADIPEGGGVVFAAQKVVVTQPTAGQFKAFSATCTHQGCAVKDVTDNVITCPCHNSTFDAATGSPTAGPATQPLPAREISVEGDSITLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6X5</accession>
    <name>A0A7K2Z6X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4937 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000100">
        <property type="protein sequence ID" value="MYW28099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032555">
        <property type="entry name" value="DUF4937"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16291">
        <property type="entry name" value="DUF4937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4937" evidence="1">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="23592" checksum="8DF6AA784616330B" modified="2021-04-07" version="1">MPRSAPYDGAVLVKWIRCSVVDRHGFERGQRKWAGLLGEPGFRGQGGGWSRTRPDVAHVFAFWENRVFYDSFMARGHDRPATGQAGTFRDMQVMLFERRFDVKTGFEPDFGDADVVRVAHSSVHEDRAEHFVLMQKQVWNPAMAGSPGMLRGVFGEAPGNEFLVLSMWKSAAERGKYRADGAERLAARAQTETDVAALTGDVVELEPSWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6Z2</accession>
    <name>A0A7K2Z6Z2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase I</fullName>
            <ecNumber evidence="3">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepB</name>
        <name evidence="5" type="ORF">GT040_02050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000098">
        <property type="protein sequence ID" value="MYW28085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="247" mass="25283" checksum="995E66508EAD09BC" modified="2021-04-07" version="1">MSGTQRNDDGRGRAGTMVSGLAVAVGCVLFLGGFLWAAVVYKPYAVPTASMSPTVNAGDRVLAERIDGGDVRRGDVVVFTDSVWGDTPMVKRVVGVGGDTVACCDEDGRLTVDGTPVDEPYIHRGPTAAGTRAPASPQDFSAKVPKGQIFLLGDERSTSLDSRVHLEDAGQGSVPLSAVQARVDAVAWPMNGMIGRPDSFAALPGGVSADGPLPLQVGAVLVGVVLILGGAAYGPVAARSARRRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z701</accession>
    <name>A0A7K2Z701_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000099">
        <property type="protein sequence ID" value="MYW28095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008761">
        <property type="entry name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05576">
        <property type="entry name" value="Peptidase_S37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029807856" evidence="1">
        <location>
            <begin position="31"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="495" mass="54776" checksum="0F06D0F6106278BA" modified="2021-04-07" version="1">MRKALTGVLSLAVLIGTVGAAGASTGAATAAEPDTKRNGLAAVHGGEASNEDIKDRILAIPGMSLIEEKPYAGYRYFVLNYAQPVDHRRPSKGTFQQRITVLHKDTARPTVFATSGYNVSTNPSRSEPTQIIDGNQVSLEYRFFTPSRPAPADWSKLDIWQAASDQHRVFTALKKIYAKKWLATGGSKGGMTATYFERFYPKDMDGVVAYVAPNDVVDHEDSAYDRFFRNVGTKECRDKLQGVQREALIRRAPLQKKFKEYAAANGLTFNTLGSLDRAYEAAVMDYVWAFWQYSLLADCAEVPADAKNATDETIWDAVDSISGFSFYSDQDLETYTPYYYQAGTQLGSPDIKQPWLGNLSRYGYQAPRNFVPRSIPMKFDRGAMRDVDSWVRNNARQMLYVYGENDPWGAEPFRLGRGAKDSYVYTVPGGNHGARVSGLTEDQRAKATAAILRWAGVAPAAVQADPAKAKPLAKFDTKLDQLNGEVERGEGILRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z721</accession>
    <name>A0A7K2Z721_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_02395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000105">
        <property type="protein sequence ID" value="MYW28150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW28150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="445" mass="47677" checksum="567EADF9ED967E25" modified="2021-04-07" version="1">MSEVLLLLLALGLTLACAVFVAAEFSLTTIERGELERAAQAGERGAESALKAAKRLTFQLSGAQLGITVTSLVIGMLAEPSLAVLLRSPLESAGLPAGAVSTVATLLGVALSTVVLMVVGELVPKNWAISSPLAVAKVVSGPQRAFTACFAPLIRHLNNTANRALRRFGLEPAEELASARTPQELIALAEHSARQGAIEQDSAELFVRTLNLAELSAENVMTPRVDVRALESHATAADAANLTLATGLSRFPVYRDSLDQVIGTIHIRDVLALEESERARTPVTALATEPLLVPDSLPVDRLLAQMRRHRTMAVVIDEYGGTAGVATVEDIVEEVVGEVRDEHDPHERPDLAPAEPLGDGRQVWEAEGSIRLDQLDRIGFSAPDGPYETLAGLLANQLARIPVRTDRVEVDGWQFDVLDIEHHRADRVRITAPAPALTLVEEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z734</accession>
    <name>A0A7K2Z734_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_02400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000105">
        <property type="protein sequence ID" value="MYW28151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="282"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW28151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="338" mass="35450" checksum="56649A0723C1DF4A" modified="2021-04-07" version="1">MTTVQLLIGALTLLTNAFFVGAEFALISVRRSQIEPDALRGSRRAKSTLWGIEHLSAAMATAQLGITISSLVLGAVAEPAIAHLLEPPFDAIGVPAPLVHPIAFVIALTLATYLHMLIGEMIPKNIALAAPAATALALGPSLVALTRALRPVIFGINAFANMLLRLLKVEPKDEVASVFTDDELVRLVKDSSDAGLLAPADGERLRDALELGTRPVGEVLVPLNRTVTVDLGITPQQLERAAVASGFSRLPVTGPDDGVLGYLHIKDALGVAERTKPLPTSAIHPVIRVEIDTPLDDTLTAMRAAGTHLAAVAGDKGTVIGFVTMEDVLEELVGPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7C9</accession>
    <name>A0A7K2Z7C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000132">
        <property type="protein sequence ID" value="MYW28259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="51"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="35139" checksum="AE59B77A5795DCDC" modified="2021-04-07" version="1" fragment="single">GLEPLPPESLGSMIDLGCASLPAPEPWLTRAFQGAVEELPPYAHTHGDYPAGLPALRRMIADRYSALGIPTMPEQIMVTTGAMGAIDAICHLFAGRGERIAVESPSYANILQLMRETGARLVPVAMEEGIGGWDMNRWRQALRDSAPRLAYVVADFHNPTGALADEQQRRDLVDAARSAGTVLVVDETMTELRLDPDTTMPRRVCAFDPAGSTVLTVGSASKAFWAGMRIGWVRAAPDVIRSLVSARAYADMGTPVLEQLAVNWLMGTGGWEQAVEIRRDQARQNRDELVAAVRRELPEWEFAVPRGGLTLWVRTGGLSGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7E1</accession>
    <name>A0A7K2Z7E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000127">
        <property type="protein sequence ID" value="MYW28251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8187" checksum="5037AF10CAC275D3" modified="2021-04-07" version="1" fragment="single">MTVDQAAQDTATSPVGERATPDALDSLGRWTLRPGVSVTVLPHGVHLRGWITSVTLEGGAGLPVLWGRLAEALAGDGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7G0</accession>
    <name>A0A7K2Z7G0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PQQ-dependent sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_03100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000144">
        <property type="protein sequence ID" value="MYW28287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029774645" evidence="2">
        <location>
            <begin position="38"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="83"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="402" mass="41848" checksum="0D9EA4F1616D8D74" modified="2021-04-07" version="1">MRGAVFGSVQSPAVRRGVVAALATASLVLSAACSTGGEEGTSGTGAASPTASRSPGSPSPGASADLPPAKGSAKVVSTLTEELKSPWGLTALPGGDLLVASRDEGTIHRIDGESGKQTLLGSVPGVSPAGEGGLLGLAVPSTFAADGWVYAYFTTTSDNRIVRMSYDEKRPAGQQLGAPDTILRGIPKGNIHNGGRIAFGPDKMLYAGTGETGDTGLAQDKESLAGKILRMTPDGEPVHGNPEADSVVYSYGHRNVQGLAWDAQKRLWAAEFGQNTWDELNLIEPGGNYGWPEVEGEEGEDGFIDPVAQWKTSEASPSGIAYAEGSIWMAGLRGERLWRIPLSGDSAEEPLADPQSFLDEKHGRLRTVVSAGGDRLWLVTSNTDGRGEPKSGDDRILLVEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7H0</accession>
    <name>A0A7K2Z7H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="186" mass="19209" checksum="617B3293E157491D" modified="2021-04-07" version="1">MEGEPGTGGGGGGGAPQLNEHGYPDNTPTADMSTEHQVAYWKHHARKHEAASKAGPDAAELERLRAADAELATRKAAELTETERITAEKATAEQAAATARAEADAAVRKALLLEVAMSKSLTPAQAARLQGSTKEELEADADALLKDFAATSGGTTHRVGGNRGSDVGNAGGVTSGAERFRQKHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z833</accession>
    <name>A0A7K2Z833_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000186">
        <property type="protein sequence ID" value="MYW28482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="270" mass="28457" checksum="5B1BBBBC7C96ABA7" modified="2021-04-07" version="1">MTVTSEQRFGEFVAVRRHAGQEHVAELVLDRPKAMNAVSTDMARSIAAACEGLGADRDVRVTVLTSSHERAFCVGADLKERNSFTDAELVRQRPTARAAYTGVLELPMPTIAAVHGFALGGGFELALACDVIVADATAVVGLPEVSVGVIPGGGGTQLLPRRVGAARAAELVFTARRVEAGEARELGLVDELVEAGRDREEALALGARMAANSPVGLRAAKKALRLGHGLDLRAGLEVEDAAWRSVAFSGDRAEGVAAFNEKRSPRWPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8G4</accession>
    <name>A0A7K2Z8G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_05035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000222">
        <property type="protein sequence ID" value="MYW28647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="120" mass="12803" checksum="4697C65ACA0E5D3D" modified="2021-04-07" version="1" fragment="single">MGEDATSGGTAESGSAPPVSVLRPVRAGNGFEETLEQVLQLLRLGLVPPGDRLPAERELAQHLGVSRVTLREVLKVLQDQGMVESRRGRYGGTFVLPRAAAADGSDELRRRVAAVDVEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9K6</accession>
    <name>A0A7K2Z9K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000310">
        <property type="protein sequence ID" value="MYW29014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="379" mass="38985" checksum="68A404B9A206CB5A" modified="2021-04-07" version="1">MAGSLTREGLTVAEGRRGGPLIVTEDAELLDDLLRLCAAAGAEPEVHHGPPGRRGGWERAPMVLVGDDAAARCRGAARRRGVMLVGRDQDDPDVWRRAVEIGAEYVLRLPDSEGWLVDQIANAAEGVGRPALTVGVIGGRGGSGASTLACALAVSAARSGRRTMLIDADPLGGGIDVLLGGERAEGMRWPDFAHSKGRLGGGALEDSLPALHGLRVLSWGRDDEVTIAPQAVRAVLAAARRLGGVVVVDLPRRVDEGVAEALAQLDLGLLVVPGELRAVAAAQRVASTVRMVLDDVRVVARGPYAAGLDERWVAQAIGLPLVGELPPEPDLLATQDAGTPPGGSARGPLARFCAEFWEQAAAAAGEPGSTVAPAGGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9S6</accession>
    <name>A0A7K2Z9S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PQQ-binding-like beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000344">
        <property type="protein sequence ID" value="MYW29107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="295" mass="29813" checksum="581D31C804511763" modified="2021-04-07" version="1" fragment="single">ERTPEGKAADGAAFSPWSTSLRTSGRATPVCSSAGAGAALYCAVAGTGTARIDPADGRVVWSDRNTALRDASAPIVSGGVVLSAGPDGKLRAYDPVKGVPVRETGLSASPGSAFPAGSTLLTVADGGTVTALDGASGVERWERPLTGHTRPDFGLYDEASGLAYAFEHAPTGTSTVVTAVDPGSGRAAWQRRLDGILTPVATAGGGELVLTEMNADMQTVGLVRYAPQKRAAVRIALPFRLDEPEVVMGGDAAYLLGRGGSLLAVDTGTPAGGKAELWRLETGVGRGSAPVLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAF3</accession>
    <name>A0A7K2ZAF3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_08460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000388">
        <property type="protein sequence ID" value="MYW29309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="3"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="23051" checksum="2F1114089A50AD9C" modified="2021-04-07" version="1" fragment="single">MAYLDHAATTPMLPEAIEAMTAQLSVTGNASSLHAAGRRARRTVEESRETLADSLGARPSEVVFTSGGTEADNLAVKGLYWSRRDADPRRTRVLAGPVEHHAVLDAVDWLAEHEGATVDYLPVDRYGRVHPEDLREAILRNPDDVAMITVMWANNEIGTIMPVRELASVAAEFGIPMHADAVQAFGQLEVGFAASGLAAMTVSGHKIGGPFGIGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAF4</accession>
    <name>A0A7K2ZAF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000371">
        <property type="protein sequence ID" value="MYW29245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="32677" checksum="B9F6FAEFD0864710" modified="2021-04-07" version="1" fragment="single">MAAQRAYTTHPLILRRVTVRSVHQVTPKMRRVVLGGEELAAFTRDGTGHPAFAAPGFDDHIKLILAADGDVRAALPAQLPHGIEWTPAEHRLTRDYTPRRVDPEAGELHLDFVVHGDGPAEAWSAAAREGDELWFVGPKSSLRLPERLDWIQLVGDETALPAIGRFLDERPLDAPAHVLVAVSDESARQELALREGDTVTWVVAEPGDAAALEAAVRALPVEAGEGYVWAAAESRALLPVRRYLQRERKLPKDRLNVTGYWHEEAPAPEAEATADAAVREPAGIPSPLPWLVARAALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAM7</accession>
    <name>A0A7K2ZAM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000412">
        <property type="protein sequence ID" value="MYW29417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="76" mass="7992" checksum="EB5BC8E017EE96E5" modified="2021-04-07" version="1">MSDITLKTAVRVNGWANTAVSAIQKRYAAKDRGQTAFEYLGIILVVVAIIGAIVATGIGTAISTRINNLVTSITTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAP6</accession>
    <name>A0A7K2ZAP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000410">
        <property type="protein sequence ID" value="MYW29409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="12573" checksum="9F1E33D4C271F0C9" modified="2021-04-07" version="1">MAGEISFFELGVDDPGKARTFYGALFGWNFEPGPSGEGGYAIGTPSGQGGVHGGDPGGGPYLFFRVDDMAAAVTRVRELGGSVEGTDLGEDDASAARFGRFRLCRDDQGSPFGLHEPPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAT0</accession>
    <name>A0A7K2ZAT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000411">
        <property type="protein sequence ID" value="MYW29412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="228"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="489" mass="53738" checksum="3D679814F1DEAC5B" modified="2021-04-07" version="1" fragment="single">MSGIQQTQLYCLADPTYYETPARLPDEKTRYPLDSAPPPEGWRRVRGGLWTSLLPEGRELAEQGWKIHVSTVPEEAEATLRDTARICLAHGVPFKFLRSEQALLLMSDKYMARSGAGKFLTLYPPDETVFLRVLDELTHALSGRRGPYILSDLRIGDAPVYVRYGAFVARWCLDADGERVHALRHPSGELVPDERGVVFRVPSWVTVPEVLRPHLAARAASGDATFPYTITESLQFSNAGGIYLARHRETGRRVVLREARPHCGLDAVGDDAVTRLHREHRALTALAGLDCVPEVYGVRSVWEHHFLIEEHIEGATLLEEIVGRFALLHGSGTAAELATYTAWVDSVTERLTQALAAIHARGLRFGDLHPSNVIIRPDGRVVLIDFEYATALDDQDTPVAGAPGLQAPTGTPGAEADAYALWATWLSMLMPLMEMAGHDRAKALTLERWARQRYGLATDAGPLRPAALVAAESRFGGESEIAALLEGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBB3</accession>
    <name>A0A7K2ZBB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TOMM leader peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000463">
        <property type="protein sequence ID" value="MYW29624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="264"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="649" mass="70079" checksum="B4889312C665BA46" modified="2021-04-07" version="1">MTTATVSLTPLDAARDQLQAALSARHSGYFGRSLPAPYVVPLGAADTLGFGHPDPYAATRPAADVQLTSRAVLIGPWGGGPSGAACGQCLAMRWQRLRSRSEREALELGHEPRGAVHWPVLTGYAVDAVWATYQAVIGGGATNPDATPADRALPQVTRIDLATLATATFPLLPEPLCPACVSEVPDTAEAARMELGPTPKPDPDGYRLRTLDSYPLPTAALANPVCGALGSDTWINPASTTTAPVAGTHFVRGYAGLNDVTWSGQANRYATSRTLAYLEGLERYAGTHRRRGTSPVVDSYRNLAGQALNPADCGFYAPETYASDPLVSPFDPDRAIPWVWGHSLRENRPVLVPARLAHYSAGVDADNFVFECSNGCATGSSLEEAILFGLLELVERDAFLLAWYGRARLTAIDLTTATTPAVRSMLDRAALHGYDVHAFDTRMDLAVPVVTALAVRRDGGHGTLSFSAAAGFDPADTVEAALSEVLTYIPHLPYQVAERRTELEAMERDFSKVLHLKDHAQLYGLPSMTRHAAEYLEPVAVLPLEEVFADWQPLRPRTGDLMDDLRCLRDQLTSAGYDVIAVDQTTPEQHRMGLHTVSTTVPGLLPLDFGWTRQRAPHMPRLRTALRAAGRRADDLPEAEIKAVPHPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBM8</accession>
    <name>A0A7K2ZBM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_10880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GtrA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000494">
        <property type="protein sequence ID" value="MYW29771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="9">
        <location>
            <begin position="40"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="10">
        <location>
            <begin position="305"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW29771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="446" mass="47530" checksum="0C1B120EAC09B8B6" modified="2021-04-07" version="1">MTTTDSLRSGPGADGRSTSGGHLPVREHLPAVPSAVPVLDVVVPVHNEEKDLRPCVLRLHDHLSRTFPYAFRITVADNASTDATPAVAARLAAELRGVRYVRLEEKGRGRALRTVWTDSDAPVLAYMDVDLSTDLNALLPLVAPLISGHSDLAIGSRLARSARVVRGPKREFISRAYNLILRSSLAAGFSDAQCGFKAIRSEVAERLLPLVEDTGWFFDTELLVLAERAGLRIHEVPVDWIDDPDSTVHIVRTATEDLKGVWRVGRALAVGALPLGRLARPFGDDPRDRALTGVPRGLARQLVGFCVVGALSTLCYLALYSLFRLGAGPQLANGGALLVSAVANTAANRRLTFGVRGRSGAVRHQAQGLVVFAIGLALTSGSLAALGVASGSTSHSAELAVLITANLAATVLRFLLLRAWVFPARAHGHAHATTHASTCSEPEDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCF3</accession>
    <name>A0A7K2ZCF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000563">
        <property type="protein sequence ID" value="MYW30040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="24556" checksum="F5AE8E8CC98D6960" modified="2021-04-07" version="1" fragment="single">MTVWDDLVGQDRVREQLAAAAKDADALVTAVSDGKPLEQGSKMTHAWLFTGPPGSGRSTAARAFAAALQCTSPDRALGGEPGCGFCDGCHTSLIGTHADVQVIRTDLLSIGVKETRDLVRRAQLSPAVGRWQVIVMEDADRLTEGAGNVLLKAVEEPAPRTVWMLCAPSLEDVLPTIRSRCRHLTLGTPPVEAVADVLIRRDGVDPERAHSAARATQGHIGRARRLATDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCG3</accession>
    <name>A0A7K2ZCG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000567">
        <property type="protein sequence ID" value="MYW30050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="23715" checksum="71182AC4FAA97755" modified="2021-04-07" version="1">ADHDLVDLAVRTADDLDRLVRGDSVPGLAAPASAGLLRGLSGAALLHLELHALTGEDRFLRAAGRALEREAGHCVTMPGGTVQVKDGRRHFLYLDQGSGGVALVAQAYLARRAAPDLSALLPGVRQGCVLEFVREPGLFTGRAGLMATAGQLSPKSRTEPDVLASARNLSWHLIAQEDRLLVPGSRLRRCSADLATGAAGLLLALHFLSGGGDGAGTGTPGLLELLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCL1</accession>
    <name>A0A7K2ZCL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosynthase chain-length factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000592">
        <property type="protein sequence ID" value="MYW30084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="1">
        <location>
            <begin position="61"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="14878" checksum="3AF8DB5B3C6C1DC5" modified="2021-04-07" version="1" fragment="single">CSWAWAAHLSTGLLSTGRDPERAYLPFDAAARGHVLGEGGALMIVEDETAARARGAHTLYGRIAGHASTLDPRPGSGREPGLRRAAALALAEAGCRPADIDVVFADAAGTPRADREEAEAITRLFGPRGVPVTAPKAAIGRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCL2</accession>
    <name>A0A7K2ZCL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000583">
        <property type="protein sequence ID" value="MYW30073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="638" mass="68438" checksum="04C46C3F6A94B582" modified="2021-04-07" version="1">SRNRLSGLDGATSLLVDALPGQEAAALFTRIAGTARTSRDPDALTLLMEACGRHPLATTLLAGRFRHRQIWDLRHLLERLAQSLDPLDELDEEVFVSAFRFSYAELAPGTRRLLRLLALHPGPDVTAPAAAALSGTGTGPGGAEGVRRSIEELLDCHLLAEPVLGRYQLHDLTRAFALRMCSAEESESARGEAVGRLLGYYLTSAHRAHRLTHPRRRALEPDQLSFYAAEFGDEQEAAAWLEAERTNLLAAARTAAAEDLGHAALFPHALAPSLRIWGSWAVTNELYGAAVAALRSRGDPLLLAQTLVEAAAVLAQTGHGEALSCAGEALTLFQDLDDPAGCADASLQASRAHLAAGHTGPSLRMAARALDLYRQRGDLHGEAECLNVEGAALHHEGRYDEALGRARLTLRMHEGTGDLLGQIRALNNIGEIHRLQGRIEHAHDHFERSRVLAQLHSGAQELAILDMNLGAVSQAMGDTPRALAGFRRALESHRGRGDALGEANALISMGSAHAENGDGGEALLHFTLAEEVARSIDSAYERTRALLGVADVHESADRPDVAFEVYGQALDLAERTGSRPAAARALAGLARTARSLGRDEPAREYGRRAVEVYRSLGSEAEAESLRRLLLGGTRRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCM6</accession>
    <name>A0A7K2ZCM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000598">
        <property type="protein sequence ID" value="MYW30131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="24589" checksum="D083092CC549EAA7" modified="2021-04-07" version="1">ALDGAHTLFLVSAHESPHRVREHITAVDAAVAVGVERIVYVSFQSAAPDATFTFARDHWHTEAHIRTADVRHTFLRDNWYLAGLPAMTGADGVLRGPGGEGRVAAVAHEDIADAAAAVLLDESAAHDGRGYDLTGPEAFTLAEAAEELSRVTGRSIRYVPETVEEAYASRAGYGAEEWEVSGWVTSYEAIAAGELATVSDAVPTLTGHPAKSFAAFLAENPDSYRHLLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCU6</accession>
    <name>A0A7K2ZCU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000603">
        <property type="protein sequence ID" value="MYW30176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="269" mass="29481" checksum="401143A31FBB7966" modified="2021-04-07" version="1">MTGQDPRAIEIDTSKPHPARMYDWFLGGKDNYPVDEQMARQLLQLDARGGDMARVNRAFMHRATRWLAEQGVRQFLDIGTGIPTEPNLHQVAQQTAPDARIVYCDNDPIVLAHAAALLRSTPEGATEYIQADARKPETILAAAGKVLDFEKPIALSLLALLHFIDDEDGAAELVDKLVDQLPSGSYLVLSHTTGDFNPEGAAQARAMYKERGMTLRPRSRAELTAFFDGLELVEPGVSLSADWRPELGEVIDVPGDEPIPGYAGVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD91</accession>
    <name>A0A7K2ZD91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000638">
        <property type="protein sequence ID" value="MYW30278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="140" mass="13951" checksum="BA9AC04DF476BCB5" modified="2021-04-07" version="1" fragment="single">LAEFDARYTQDGDGVHGARAMAAAIAVALAGADVDAVVNAALAQLPGGTEIARNAEHAVRLAREFADEPAGAFALVPVLEHQIVDHVYSYGIAAAETVPVALALTTAARGEIAQALPAAACLSRVADSAPALAGALTGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDB5</accession>
    <name>A0A7K2ZDB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000628">
        <property type="protein sequence ID" value="MYW30265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="77"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="173" mass="17971" checksum="C39C560624941020" modified="2021-04-07" version="1" fragment="single">MSSQNTSSSSPTVGRVRNWLQGRDLSVFHSVADRHWPGADPLLPQLSRSANHGLLWFGTAIGIAALGSSARSRRAALRGVASLAVASAAINTVGKGAVRRQRPILDQVPVMRQLKRQPITTSFPSGHAASAAAFATGVALESKGWGAVVAPVAVAVAASRVYTGVHYPSDVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDF9</accession>
    <name>A0A7K2ZDF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000656">
        <property type="protein sequence ID" value="MYW30349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="46" mass="5271" checksum="1FD2D769637709E1" modified="2021-04-07" version="1" fragment="single">MSRIALVTLIVRDYDEALAFYRDALGFELVEDTDRGDGARWVVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDR4</accession>
    <name>A0A7K2ZDR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_14495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000674">
        <property type="protein sequence ID" value="MYW30458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="492" mass="50329" checksum="2890A4436530B334" modified="2021-04-07" version="1" fragment="single">MRRTKQIRHAEGLPRPPKARTSPIVPVLAFAGITVAVMQTLLVPVIKDLPVLLSTDPANATWVMTATLLAGAVSTPIMGRLGDLYGKRRMLLASLAVMVIGSLICASTDDLVVMIVGRALQGFAMGAIPLGIGIMRDELPREKLGSAMALMSSSIGVGGGLALPAAALVAQHADWHALFLGSAGLGVLAMALTYTLVPEPPLRAPGTFDFIGAFGLSLGLVLLLLPITKGGDWGWASAPTLGLLAASVTVLVLWGLFELRTPAPLVDLRTTARREVLLTNLASIMVGVAFYAVSLVLPQLLQLPTSTGYGLGQSMVVAGLCVAPLGVTMMFVAPLYARISARRGPKSTLMLGMLIIAIGYGAGLGLLSAAWQTVLIAVVLGAGIGLAYSSLPALIIGAVDPSETGAANGLNTLMRSIGTSVSSAVIGMVLANTSVTTGSAQGAVQVPSMEGFRISFLIATGAVLIGLVLAAFLPSQRPSGHPVLLASSADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDZ7</accession>
    <name>A0A7K2ZDZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_14985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000714">
        <property type="protein sequence ID" value="MYW30548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="222"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW30548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="433" mass="46301" checksum="ED1B7CA9C83D0F90" modified="2021-04-07" version="1">MTAALLGLLAVFVLTAGTGYFVAQEFAYVSADRLTLSREAAAGDKRAAKAVTVLERLSFMLSGAQLGITVTGLVVGFLAEPSVSTLLRPALDGTGLPGGVVSAISVTLSFVVATVIQMVLGELAPKNLALAVPERLAKSLATSTLIYLRIVGPVIHVFDSAANRLLRRIGIEPVEELHHGATLEELGHLIGESHEQGELPAATAELVDHALEFSERTLGEVMVPRADVTFVRREAMALEAVELIGRHGHSNYPVLGDHPDDPAGVLGVRELMRLPASDVGRTTAGELARRPLLLPEILKLPAAVAQMRERDDEFAVVLDEHGGVAGIVTYEDIAEELVGEIADESDPVDELAVADGDGWVVDAGRRLDEIEEATGIVLPEEGDYDTLAGLIIDRLGRFPTVGDRLTVSEVRIEVRTLDRHVAEYVRIEQEPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE11</accession>
    <name>A0A7K2ZE11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PASTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000719">
        <property type="protein sequence ID" value="MYW30591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="240"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="305" mass="31887" checksum="AEF882FB32A4137F" modified="2021-04-07" version="1">RGARRGPFGGPHRKLITIITAVLLTLGVGAGVWYINSGQFTQVPSLLGQTQKVAERRLADEGLGLKGVERVFSDTVERGSVVGSDPASGDRIRGNGSVKLVVSRGPEIVRVPDVAGSSLADARRSLKKVGLAPGMVTREFSEDVARGEVIRTDPRAGTDRNPDTAVALIVSKGSPVDVPDVTGLSVEDATAELAEEGLKVDVLPGRVHSAEVDGDIAKQSPGAGTEAAEGDTIELTVSKGPRMLDVPDITGRDVDEARATLEEAGFEVKVDRPFLSFSDTIASQSVEGGEQAPEGSTITIRTKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE20</accession>
    <name>A0A7K2ZE20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000716">
        <property type="protein sequence ID" value="MYW30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="28389" checksum="510720F3CDF64858" modified="2021-04-07" version="1">MKRTVLTFDGVARGLAEYGDPHGRPVVLHHGLLGDAGLPAVWDTLARGAAVRLIAVDRPGYGLSDPVPMAAVGDWTAQLLPALKACGVGGFDVLGISAGAPYAYALAAGLPERVRRVWVLSGLPYVPDVAVRGRYPEEAEPVWTFYREAPEAELVARFAGAAERMAEVFAASPSTLTALPRLAAHGWRGPAREVRLQTRPWGFVPGEVAQPVRLWHAPADQEVPFPAAEATTALFPAARLTEQSAPDHIPSEATVGELFAELRAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE70</accession>
    <name>A0A7K2ZE70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HlyD family efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000721">
        <property type="protein sequence ID" value="MYW30618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029823989" evidence="2">
        <location>
            <begin position="36"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="361" mass="37283" checksum="1F7FA51F621CF29A" modified="2021-04-07" version="1">MRERGPMRRGRAVAAVAAVLAVTAGTIAVTQFGGGSGGTEATGAKNTGLPPATAPVERGDLHDSAQADGTLGYDRQRKINAAAAGTLTWTPRTGATIERNERLYEVDGRAVRLMYGAGPMYRTLKAGDEGRDVEQLERNLAALGYTGFTPDTEYTELTAAAVKRWQKAHGSKQTGTVGPQDIAFAPGKVRIKGVAAAVGDLAQPGAPLLTTTGSERIVTFELDVAESRLAKAGTEVDVDLPDGTSAAGTVSSVGRTAKPGKDPQDTGPKVTLTVSFDKPDEVGGFDQSPVTVNLTGETRKDVLTVPVNALLALPGGGFGVEVVRNGTAREVEVELGMFAEGRVEVSGGGLSEGMKVGVPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEC8</accession>
    <name>A0A7K2ZEC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_15715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW30686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="310" mass="33628" checksum="B9A53C344B6AD82C" modified="2021-04-07" version="1">MAGVKRRSGADGAHPRPGTAARDRAAWFLVLPALLPILILSVGPLLYGIALAFTDAQSGRTRSTQWIGTLNFQDLLHDTLFWDSFRIGLLWAFGVTVPQFLLALGLALLLNQKLRLRWLARALAIIPWAMPEVVVGIMWRLVYNPDAGILNETLRDLGLGDGRDWLTGLATALPAVILVGIWAGMPQTTVALLAGLQNTPHELHEAAALDGAGAWRRFRTVTWPAIKPIALAISALNLIWNFNSFALVYVLTSGGPGGRTRLPMLFAYEEAFRYGQFGYAAAMGCVMVAVISVILACYLVGRISAGGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEX5</accession>
    <name>A0A7K2ZEX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000786">
        <property type="protein sequence ID" value="MYW30903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="42" mass="4192" checksum="553B0562BB40810E" modified="2021-04-07" version="1">ADAAGEGGAELWLERGMGHAENAADDALLGRIADWATGALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF90</accession>
    <name>A0A7K2ZF90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000813">
        <property type="protein sequence ID" value="MYW31002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="21354" checksum="3EB16FDEC52E1C81" modified="2021-04-07" version="1">IDRRLVSLRTRAQALTTRAGSVEPVLSELRRRFSAACWQDLQPVPEQAAVNVAQAEEKLAEAARARDEQRWADATSRLSTVRALLNAVDEAVSAAGDRLQRLDAVAKDPQHEIERTRFAVRDAQRLAMAGRHTPDPRHARPLDDSVARLDRAVAGLEGRHPDYWHFLTETEAVRQTAARVVSDIREERGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFI9</accession>
    <name>A0A7K2ZFI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_17885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000851">
        <property type="protein sequence ID" value="MYW31102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="29864" checksum="4841B6AE8772E8B5" modified="2021-04-07" version="1" fragment="single">SDGALPIEYAEVTITRIMFRNGGSEYQINGDTCRLLDIQELLSDSGIGREMHVIVGQGQLDSVLHADPMGRRAFIEEAAGVLKHRKRKEKALRKLDAMGANLARVQDLTDELRRQLKPLGRQAAVARRAAVIQADLRDARLRLLADDLVTLRDALRDEIADEAELKKRKDAAEAELKAALAREAELEGEVRRLAPRLQRAQQTWYELSQLAERVRGTVSLADARVRSATEAPAEERRGRDPEDLEREAARIREQEAELTAALEAAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFX0</accession>
    <name>A0A7K2ZFX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_18610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01000867">
        <property type="protein sequence ID" value="MYW31232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029930381" description="Glucanase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="33551" checksum="7A66A52E4B166584" modified="2021-04-07" version="1">MRRLLRTLAASAFACLLLPLSAAPSSATTASVQASPIGMTSGFYTDPSSGPAAWAAANPGDGRAAAIRDNIASRPMARWFGAWSGDIGAAVGSYVGAADAADKLPVLIAYNIPGRDACGGHSGGGAGTPAAYRSWISAFASAIGSRPALVVIEPDSLGDFSCLSQAQIAERNGMLRGALTQFRDRAPNTWTYLDAGNPAWIGAATMAQHLDGAGAREAHGFSLNISNYFTTGENTAYGNAINSALSSSYGYTRPYVVDTSRNGNGSNGQWCNPGGRRIGAVSQTGGGGAEMLLWLKTPGESDGNCGVGGGSAAGQFLPEVAYKMIYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG06</accession>
    <name>A0A7K2ZG06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000880">
        <property type="protein sequence ID" value="MYW31294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="33" mass="3449" checksum="5B6BCC1F5CB1FF39" modified="2021-04-07" version="1" fragment="single">MAADTPRVRDRLAEAAARAAQDVPGVAFLRPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG69</accession>
    <name>A0A7K2ZG69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000893">
        <property type="protein sequence ID" value="MYW31326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029816944" evidence="2">
        <location>
            <begin position="25"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="392" mass="38226" checksum="11E7B50BD420380E" modified="2021-04-07" version="1" fragment="single">MSAAGIALMLGGAGIVLAASPAQAAEVSYATECVPPPISGLPPVQGTTKVLLTAPAEAKVGDEIEVVWKTVDAASKNPDVLDLGKDTVKPTGTITLGGAASGELKLEGPRQNPPIPKNSPMLLPDMKAKLKLEKAGEITLTPGAYTINVSKPISTDTKCAPKETVQPGATIKVTEGGSSTGGTTSGGTDSGGTTTGGTTTGGTTTGGTTDGGATTGGTTTGGTTTGGTTSAGGTTSGGGTTGSTTSGGSTGGSGGETDFPGKEVSVAYACKTPIGDKKATSPVRISAKKNGGAYDLTVKFSKSVMDSPIDIPADQVKPSMEVKLGGVDKGTVKVEGPLNKEVIKTGAPIEIPDLTGTYKPGASGTSTLSPGVLTVMAAGTTTTCTPPADVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGD9</accession>
    <name>A0A7K2ZGD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000913">
        <property type="protein sequence ID" value="MYW31417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041669">
        <property type="entry name" value="TetR_C_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17918">
        <property type="entry name" value="TetR_C_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="23593" checksum="CCC160BAE6C7485F" modified="2021-04-07" version="1">MPSADRRLQPRRKPRQVRAELTRERILDAAAHVFAEYGYAAGTTNRIAEHARISIGSLYQYFPNKDSVLAELLVRHIDRSAWTQADQLDLSPGSLRTMARALVRDAIDNHRDDPQLLRIMIEEASFSQELLDTIDRHGKQRVSQVRDLLARHPDVHVRDLDTAAELILFTVEMNTHKHMADPRSIPEEALENELTDLVTRYLGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGE9</accession>
    <name>A0A7K2ZGE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000919">
        <property type="protein sequence ID" value="MYW31441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PTHR10961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="4"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="370" mass="38925" checksum="CBC3995B56E742DF" modified="2021-04-07" version="1">MALRVLVVGGGLMGAAAAWRLSVRGHQVTVLERFGPGHDRGSSYGTSRIFRLAYAEPSYTELALRALPLWRRLEEESGQSVLTLTGAVDHGLPEAVKRLADVLAGAGRSAQRLSPGEVADRWPGLRADTTALYHPDAGRVHADDAVSALLKAAGQRGAEVRHGVRVTEIRDTGRTGGGVTVVTDADEALTADAVVVAVGGWAPGFLPDLVSGLPPMRVTQEQPVHFPVPDALDWPSFIHHPGAGWHVPGGLYGLGSVDGVKIGLHGVGPVVDPDHRDRTPDPAAVERLRAYAEEWLPGVAGTEPAPLTCLYTTTPDEDFVIDRQGPVTVLAGFSGHGFKFGPAIGELAADLVEGRPGIALFALGRTARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGF3</accession>
    <name>A0A7K2ZGF3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">sucD</name>
        <name evidence="7" type="ORF">GT040_19605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000914">
        <property type="protein sequence ID" value="MYW31420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561710.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000914.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="294" mass="29966" checksum="F465EDDBD18077A0" modified="2021-04-07" version="1">MAIFLTKDSKVIVQGMTGATGMKHTKLMLADGTNIVGGVNPRKAGTSVDFDGTEVPVFGSVAEAIEKTGANVSVLFVPPAFSKAAVVEAIDAEIPLAVVITEGIAVHDSAAFWAYANEKGNKTRIIGPNCPGLITPGQSNAGIIPGDITKPGRIGLVSKSGTLTYQMMYELRDIGFSSAVGIGGDPVIGTTHIDALAAFEADPETDLIVMIGEIGGDAEERAADFIAKNVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPTETAKLAREILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGX2</accession>
    <name>A0A7K2ZGX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_20530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000970">
        <property type="protein sequence ID" value="MYW31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="142" mass="15209" checksum="15B2D78936AFDFD0" modified="2021-04-07" version="1" fragment="single">MSSDPAPVVEAGTYRLRNVGSGLVLEVYGAAKGSGARVQQGKDDGTAAQQWQLSPVHEGAALYHLVNAHSGKRLDVANAHTENGVRVQQWKANNFGAQEWLIEQHLEAPGTVTLVSFISGLAMEVANRSTEEGGTVQQWEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH58</accession>
    <name>A0A7K2ZH58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superoxide dismutase, Ni</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sodN</name>
        <name evidence="1" type="ORF">GT040_20975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01000984">
        <property type="protein sequence ID" value="MYW31684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966342.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6214170"/>
    <dbReference type="GeneID" id="66955603"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02753">
        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14861" checksum="FBE2EE52BAFD7618" modified="2021-04-07" version="1">MLSRLFAPKVKVSAHCDLPCGVYDPAQARIEAESVKAVQEKYQANEDADFRTRAVLIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELHQLINDTLKALSAAKGSNDPKTGQKALDLIAEVDRIFWETKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHA1</accession>
    <name>A0A7K2ZHA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase SLT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_21295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001013">
        <property type="protein sequence ID" value="MYW31743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029442151" evidence="2">
        <location>
            <begin position="34"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="241" mass="25253" checksum="43C2D723C91790E8" modified="2021-04-07" version="1">MSRISVRGFAVASATAVTTVGAVVGVAAGGAPAADDNNFEAAAADTTLLADIPAGQQAQVQTASLTQQADAQASAADSAAKKSAEESARLQAAKDAKSKKAAAEAKAEAERLAEEKAEKEKKEAAERASRSSVRDASSFSAQGSYTVAQVQAMARQMVPADQFQCFSNIVNHESTWNYRATNPSSGAYGLMQALPGHKMSSAGADWQTNPATQIKWGLSYMDGRYGSPCGAWSFWQANNWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHD2</accession>
    <name>A0A7K2ZHD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein GT040_20845</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000980">
        <property type="protein sequence ID" value="MYW31659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026241856.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000980.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="114" mass="11539" checksum="A582C00D34CCC52B" modified="2021-04-07" version="1">MIPGGGQPDMQQLLQQAQKMQQDLAAAQEELARAEVDGQAGGGLVKATVTGSGELRALVIDPKAVDPEDTETLADLVVAAVQAANENAQALQQQKLGPLAQGLGGGGSIPGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHG5</accession>
    <name>A0A7K2ZHG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine gamma-lyase</fullName>
            <ecNumber evidence="5">4.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_21430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044540">
        <property type="term" value="F:L-cystine L-cysteine-lyase (deaminating)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="374" mass="40056" checksum="105EB9C5322F8BDD" modified="2021-04-07" version="1">MSTMGDGTRAVRAGLPEPEQYEPTLPGPVFAAHFHLSGEPVGPYTYGRDTNPTWTHLERAIGELEAPGEDVSTTVFASGMAAITAVLLSQVRTGDTVVLPDDGYQALPLVREQLTAFGVEVRTAPTGGDAQLALLEGTKLLWIESPSNPGLDVCDIRRLVAAAHEAGSLVAVDNTLATPIGQRPLELGADFSVASDTKGMTGHGDILLGHVTCRDPLLTADVRRWRKVVGAIPGPMEAWLAHRSLATLQLRIDRQCTTALALAEALAKRAEVTGLRYPGLPTDPSYGIAVRQMRRFGSVVSFELADRETAERFLTALRLVDDATSFGGVRSTAERRGRWGGDAVPEGFIRFSVGAEDPEDLLADVERALDEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHW4</accession>
    <name>A0A7K2ZHW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SseB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="109" mass="11561" checksum="1D040C12E17C10D4" modified="2021-04-07" version="1">MLGEFRRTAVLVPFDAYGSLWTADQNGVRWICAFSDEEALARFALAQGDGAREWTYRTILGARLLDVMVPMLPGPAGVALDAGSTDGVLFPPVAGIVPDHVAVDLGETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIA3</accession>
    <name>A0A7K2ZIA3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_22555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001063">
        <property type="protein sequence ID" value="MYW31979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="24590" checksum="20C2003FD3952D27" modified="2021-04-07" version="1">MLVVDDDFMVAKLHSRYVSAMDGFTVAGVAHNGAEALRAAERLRPDLVLLDIYLPDMDGIDVLRALRAAEERDASRPSTDALFITAARDAAVIRSALRAGALHYLIKPFNRSALQGQLRHVAALRTRLDELGEARQEDVDQIFGTRPPGSRELPKGLAAPTADLVERTLRGSPEGLSATECAEAGALSRVSARRYLEHFAGTGRAEVTLRYGGTGRPERRYRWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIP8</accession>
    <name>A0A7K2ZIP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Relaxase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="2">
        <location>
            <begin position="11"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="656" mass="72624" checksum="80E2A632D240CF41" modified="2021-04-07" version="1">MTVDIRVIRAGQMYRYYLRETVVGDGRRPARTPLRAAQEQAGVPAGRWMGRGLAVLGLAPGEEVTEAQLRNLFGERGRHPYADRIEADRLAAGDSPKKAYRAGALGRRVTVTGVDFVFRPQPTIYLLWAFGDEETRRVIEAAHERAIERVLEWIEDEVAVIRYGKDGIYRVRPPGGLIAARFRHYEARSGRPLLHDHLMVSVKGQRLDGKWGSIHTTALHENTVAASALYNELVASEVCEALGLATEPRTVTPGRRPMMEIAGVPHELIRWTSRRSDQIAACLTELEHEYVTAVDDDGEPLFLPVVSERARAKLNAIAARKTRPPKQSARPLAQLRAWWKASAILTSGVAADVITSLLEYARAAAAAIRARVAAVVDIALAAVDVAATVFVMNDGGRFHRRHLLAEARRHLAFVLRGRRRDPGLDDQVVAAAISTHCLDISEPKTVRGLEAGYRLYTARWALSDLPARRRSPTAAPDPDQHPPADPGEPAAPRPPGQDVGEWEIPRIPLQYDRAVLAGAVVREKLNTTGAAAVRGRAYDVVAHQQAAMPEQLLAPEPADPEHDDQEQKPGRREALDMTALRALRESRTDVEALDVTAERLRHLQDAFSEAADRAQSTMDRYTRRDDTETPHPVRRDDQQAHHPQDPGPHRGREAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ78</accession>
    <name>A0A7K2ZJ78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001159">
        <property type="protein sequence ID" value="MYW32403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="367" mass="39023" checksum="A28D624012EA5C10" modified="2021-04-07" version="1">MSASPGALASYRPALRPRVLLSDPLLDGSATVHLIKDTDTGNSFKVGAKEHFLIARMDGGRSLAEIGEEYAGEYGRRLGDTHWQQILTMLGTKGLLTGTPVPEAPVVPAEPRTLLRGTLPLVADADATTARLHRVVGFLLAPWAMVPLLVLIVAMEAVAVARSGELLIAVRELFANPVLLTGTAILLWTSTALHELAHGVVARHFGGRVAEIGLRWRLPVVIMYCTVDNYLYLGSRWHRIATAVAGAVMNLLFLLPFCALWLFAPLDDATHEALAALLLLGSVQAFAMLVPLPPLDGYKVASQLAGATGLAASAGGYLRLVLRRSPEAAAYPRRARIAYPVYVLGTVLVLAALVAALAAGAHHLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJA0</accession>
    <name>A0A7K2ZJA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hybrid sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_24875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001161">
        <property type="protein sequence ID" value="MYW32415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="181" mass="19561" checksum="B7C06AC94FE63D5D" modified="2021-04-07" version="1" fragment="single">MTVPAARSASLSAFDLATAQDVFVLRRIGQSAAEALGMDRQDQVRIATALSELGRDRLGCTGLTVSFTLPPGPESVLAVVFEWDGGTETGSWDSGTKPAPDLEPAARLLNRVRHESGGARERIVAEHPLPADWSDTPAARLGVRAALRRHAPMTLADDLRAQTRDLIATLEETRAQREELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJA7</accession>
    <name>A0A7K2ZJA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">grpE</name>
        <name evidence="8" type="ORF">GT040_24910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001163">
        <property type="protein sequence ID" value="MYW32421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="23218" checksum="7076BBD728E4E163" modified="2021-04-07" version="1">MTEETPGFDEKPDVPSGATPDDAEPKAAAPSEEEAAAPAGDTDQTVGLTAQLDQVRTALAERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVLDDVGRAREHGELVGGFKSVAESLETVVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQPGYRIGERTIRPARVAVAEPQPGATPAAAKEEKTDDEESGGTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJM3</accession>
    <name>A0A7K2ZJM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_25590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001198">
        <property type="protein sequence ID" value="MYW32552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="189"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="396" mass="42228" checksum="732B81180D56ED0E" modified="2021-04-07" version="1">MRALTYQGKRDVRVETVPDPRIQDPTDIIVKITSTGICGSDLHLYEVLGPYLDPGDILGHEPMGIVEEVGPDVHSVAPGDRVVIPFNVSCGHCYMCGSGLHSQCETTQVRERGTGASLFGYTKLYGQVPGGQAEYLRVPFGNDLPIKVPHGPSDDRFVYLSDVLPTAWQAVEYADIPAGGSVTVLGLGPIGAMAARIALHRGAGLVIGVDRVPERLDRVSAYGATCLDLRRYAKGKDLGDAVRDLTDGRGTDAVIDAVGMEAHGAPVAKAAHAAVGLLPDTVAQRLMETAGIDRLTALHTAIDLVRRGGTISVSGVYGGSADPMPLLTMFDKQIQLRMGQANVKRWVDDLLPLLVDGDPLGVDSFATHHLPLEEGPQAYETFQKKADGMIKTLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJR4</accession>
    <name>A0A7K2ZJR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tatC</name>
        <name evidence="7" type="ORF">GT040_25775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001200">
        <property type="protein sequence ID" value="MYW32587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="34827" checksum="AA1F735E2E600062" modified="2021-04-07" version="1">MLKSARKQEKDDEGRMPLLDHLRELRNRLLKAVLAIIVVMIVAAFYQKEIYEFLLAPIQESVGCKNGVVTTVDGKSCALLKTDTLIGPFTNALKVALMSGVLLATPVWLYQLWAFVAPGLHKGEKRYAYAFAVVGAPLFLAGGYLAYAILPQTAEIMLGFSPDDVQNQIGLDSYLDLLVRMVIVFGLAFELPLLLIALNMTGVISGKRMLGWWRGMIVGLTVFAAFATPGGEPISMLLLAGPLSLLYFIAVGFSLLNDKRRNRANPDAELSDDEASDLDLTPEPVEGVKPVAAPRKALPEQASGEADGSGSQRLNGYDDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJW7</accession>
    <name>A0A7K2ZJW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001208">
        <property type="protein sequence ID" value="MYW32633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="98"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="24298" checksum="8F84B2C2FFA81A5F" modified="2021-04-07" version="1">MHSPHIARADDRSPRPAAALAAGTAGIALFVVLLALVAAQWSPLMSLDHTVADALHRHAVAEPGLVHVNRVLTDWFWDPWTMRALVAAAVIALWWRGARLLALWVAAASLLGSLLSQGVKAAVDRERPRWPDPVDSAHFSAFPSGHAMTAVVSCGLLLWLLRLYGAGPALWAGAVAVAVVSVIGVAVTRVYLGVHWLTDVVGGTLLGVAVVAFTAAGYARSVSRKAPEPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJX0</accession>
    <name>A0A7K2ZJX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_25995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001207">
        <property type="protein sequence ID" value="MYW32631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="261"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW32631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="453" mass="49459" checksum="533512A702D7CF24" modified="2021-04-07" version="1" fragment="single">MAGRINDDDVKAVRDAVPIDSVVSEYLQLRSAGGGNLKGLCPFHDEKSPSFQVSPGKGLFHCFGCQEGGDTIAFVMKIDHLSFSETVERLAAKAGITLRYEEGGYNPSHQRGERIRLIEAHQAAADFYVRALESPEAEIGRKFLAERGFDQDAATHFRVGYSPAGWDHLTRYLRGKGFSDKELITSGLSQDGRRGPIDRFRGRLMWPISDTAGEIVGFGARKLRDDDNGPKYLNTPETPIYKKSQVLYGIDLAKKDIAKASRAVVVEGYTDVMACHLAGVTTAIATCGTAFGNDHIKILRRLLMDNGSARVIFTFDGDSAGQKAALRAFEDDQKFAAETYIAIAPDGMDPCDLRLAKGDDAVRDLVEPRTPLFEFALRQIVGRYDLETPAGRAAALDEAAAVVAKIKTSSVQREVAVQLAGFVGILDQEFVVRRVAQLARWARDKGGDGRGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK90</accession>
    <name>A0A7K2ZK90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001249">
        <property type="protein sequence ID" value="MYW32767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="5890" checksum="9ADAC1D1FB163E03" modified="2021-04-07" version="1">GTGTTGDATGGTDGGGGATGETGNGGTGTSTGTEGGTDGDNGDSDGDTGALGGGLIEGVRGAREQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK99</accession>
    <name>A0A7K2ZK99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_26740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001250">
        <property type="protein sequence ID" value="MYW32771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561783.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001250.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW32771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="20880" checksum="FA38A36DC111283F" modified="2021-04-07" version="1">MRDDETTAIGALVHRAVDGDAQATHDLLAHVHPLALRYCRSRLNRLPGDARHFVEDLAQEVCVAVLMALPRYKDTGRPFEAFVFAIAGHKVADLQRAAMRHPGSTAVPSDEMPERPDDSLGPEERALLSSDAAWAKKLLANLPESQRELLVLRVAVGLTAEETGRMLGMSPGAVRVAQHRALSRLRALAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKB9</accession>
    <name>A0A7K2ZKB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenosylcobinamide amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001254">
        <property type="protein sequence ID" value="MYW32804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002808">
        <property type="entry name" value="AdoCbi_amidolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01955">
        <property type="entry name" value="CbiZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="20684" checksum="A73BCB6A124D6161" modified="2021-04-07" version="1" fragment="single">MRSVRPQLPAQRGELRDRHEDGHHLHHLVWRLGPGVRVCSSAVLGGGIGPRAWILNAQVPGGYPRLDPDRHLAEIAASEGLTGPGAGLMTAADVAAYTTGHDGGVTTTVTTGLGVRGWAAAPESVTRTPHRPGTVNIVLTLPAALSDAALVNAVATATEAKVQALLDAGLDCSGTPTDAVCVAAPEPGPDGGEPFAGPRSTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKD7</accession>
    <name>A0A7K2ZKD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001254">
        <property type="protein sequence ID" value="MYW32812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="15620" checksum="5B521A83B9106938" modified="2021-04-07" version="1">GAGSSTDAHHPTAPAPDGRGAQRAVQAALDQAGWQPGDVDHINAHGTSTPLNDAMETTLISRLFPHRPPVTAPKGVVGHTLAAAGAIEAVATVLTLERSLIPPIANLDALPDAFPLDCVVKEPRHQRVERAVSHSFGFGGHNVALAFQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKH7</accession>
    <name>A0A7K2ZKH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001265">
        <property type="protein sequence ID" value="MYW32857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014262">
        <property type="entry name" value="Extracellular_HAF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02913">
        <property type="entry name" value="HAF_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029486883" evidence="1">
        <location>
            <begin position="45"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="358" mass="36591" checksum="2B148A742FA805A6" modified="2021-04-07" version="1">MTIMSLPAAERTGAPRGASRVRRALGVVAAAAALVVTTGIPAHAAPTPVPLAPLPGGTFSGAYGLDDRGVVVGFSENRAGQRHAARWTPSGRVTDLGTLSGDTQSEAYTVREDGTVIGMSTRPGGPDRAVKWSSSGRATELPGLRDATVTRGYVINDAGTVVGISSTPAGVHRPVRWSPSGKVTALRTLPGDTTGGVGAVNDAGVAVGYSGIPGGVLTSMRWAADGSYRTLKPLPGDDSSHASWINNRGVAVGHSYVTGSDLIRPLRWDADGTPRALRLLDGDTGGSSWGINDKGYSTGYTYRPGGEAHAVVWAPDGSVTALGSPTAGGGEGYQINRHGVVAGYTTKDGATRATAWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL40</accession>
    <name>A0A7K2ZL40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001311">
        <property type="protein sequence ID" value="MYW33067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6804" checksum="288CE9212808C08E" modified="2021-04-07" version="1">MKRHGLRIDPISSTERERGIIIHPDTQASLDKAVPVRPNPQARTCTTRTKKNTEKKSPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLD2</accession>
    <name>A0A7K2ZLD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PD-(D/E)XK motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001348">
        <property type="protein sequence ID" value="MYW33174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025534">
        <property type="entry name" value="DUF4420"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14390">
        <property type="entry name" value="DUF4420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="336" mass="37254" checksum="C844E5C256013467" modified="2021-04-07" version="1">MTVTEEEWQELEAPQGAPGRSRLRLHPEAPLDVFLSVTHPGHQRMLVLRTDARSADHIVRSVGKLPKAAGFEMHLSAVSRLEYELQVILTANELREVFNPLVSDVADTVRSAPEAAAALTAAVDRFERWQDLLRAVSRDGLGPEARRGLVGELLVLRDHLLSVLDPTEAVEAWTGPSGANQDFQMPGVAIETKASTAKRPRGIRVTSERQLDDTGTPALLLALTLLDERRGGTGASLNRLVNEIRERLTSPAVRARLDGRLIQVGYLPGQHELYDEPRYTLRDLRFWHVREDFPRIVESDLPDGVGDCSYHVSTSGLDRFRATADEVTELIKGPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLJ8</accession>
    <name>A0A7K2ZLJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001353">
        <property type="protein sequence ID" value="MYW33210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="18224" checksum="604C3135D055537E" modified="2021-04-07" version="1">MPHSARRPRTCAEVSADASAASELLEVLWGRGQEAAASGTVSPSQLRALLVIEKQEGTNLRSLGEALGSRAPSVSRLCDRMEAMGLVQRAPSPTSRREVVLRLSLRGRALLEEYRALRTRELSAVLERMEPAAVAALAKGLAAFHAAASDRLSPEKGATDPLLRDDVADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLN2</accession>
    <name>A0A7K2ZLN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpsP</name>
        <name evidence="5" type="ORF">GT040_29430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001362">
        <property type="protein sequence ID" value="MYW33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030569580.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001362.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="146" mass="15871" checksum="E2C2EDB46CAB8E66" modified="2021-04-07" version="1">MAVKIKLKRLGKIRSPHYRIVVADSRTRRDGRAIEEIGLYHPVQNPSRIEVNAERAQYWLSVGAQPTEPVLAILKLTGDWQAHKGLPAPAPLLQPEPKADKRALFEALSSDGDEAKGEAITPKAKKADKKADEAADAAASTESTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLN9</accession>
    <name>A0A7K2ZLN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001360">
        <property type="protein sequence ID" value="MYW33263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="150" mass="16940" checksum="8A11BBCEF1E88D95" modified="2021-04-07" version="1">MVDVRRSFTVACPLDRVVAYLADFSRAKEWDPGTQECDRTDGPAGAPVVQGATWHNVSEFRGRRTELTYRLEVKEPDRLVFVGTNKTADSTDDLTFRAEGEGATRITYHAHIRFRGVARLADPFLRREFERLGDEITRTMPRAVLAHCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM94</accession>
    <name>A0A7K2ZM94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_30220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001394">
        <property type="protein sequence ID" value="MYW33428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509689.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001394.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="13930" checksum="7C3D6764FE84356A" modified="2021-04-07" version="1">MAITLLDPEGLPKVGVYRQVAIATGSKLVFIAGQVAWDADGTTVGEGDLAAQVERCYLNIGTALAGAGGTFDDVVKLTVYVVDWTPDKMPRFLEGAARAAAKLGVTPVPPGTLVGVAALDVPEHLVEIEATAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZML8</accession>
    <name>A0A7K2ZML8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="17177" checksum="F62C8BEDD07EA9E2" modified="2021-04-07" version="1">MTTQPDRIALDDLTSDALDALYDERDAARATARRLNYRAQQAESKNAAFERAVSQWDVNERGTYIPHTSLRAIGIAAGTDILGSVRHLKHFQRVEQAEARVRALEAEVTRLTAGQCTHALAACEQHHTTPVAGCPYPRCRAATDRDQRAATAPGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN01</accession>
    <name>A0A7K2ZN01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001438">
        <property type="protein sequence ID" value="MYW33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="291" mass="30724" checksum="84465C437D5D270A" modified="2021-04-07" version="1" fragment="single">MDEALDCACTGGNALMYVVGPRGMGKTRMLQEAAETARRRGFRLVRGETRAAAPGDSVPTLVVVDEPFRTGAWPDREALGPRPSSHTVWMTASPAGTPPRRADGIDVPPFLCTTRLVLGPLSTDAVRDLASDLLGARLDGPLLRLLEQVGGHPGLLIELIRGLQEEGSVRTVSGVAELVTSRVSEHACFYVRDTLADSSGLCRQLLCLMALLDDGCGPETLSRLLGISTAALIPVLEEAYATGLLHDQGGAPAFVSLLARCLVAETVPQAVRTALRRERAALGGPTAHPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN09</accession>
    <name>A0A7K2ZN09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_31705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001445">
        <property type="protein sequence ID" value="MYW33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="88"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="292" mass="31798" checksum="F0C87F6EE98C9E83" modified="2021-04-07" version="1">MSTPIEPEARQSLGARIAARLGGGVMRVFLILVALFWIMPTIGLFLSSLRGPEDIAGTGWWKVFTAPSELTFDNYQRLLDNSTITGSLLSTIMITVPSTVLVVVIGSLAGYAFAWMDFPGRDWWFLLVVGLLVVPVQVALIPVSELFGTIGIFETTLGVVLFHTAFGLPFAIFLLRNFFAEIPRELLEAARLDGAGEIRLFTRVVMPLGGPAIASLGIFQFLWVWNDMLVALIFAGSDSPPITVALQQQVRQFGNNIDVLAPGAFVSMVIPLVVFFAFQRQFVSGVMAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN98</accession>
    <name>A0A7K2ZN98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="16944" checksum="188CA77B5F6D3D1E" modified="2021-04-07" version="1">MAADLWTSVVSLAGVALGGGLTALAQRATQRSAERVEERRQTIATTESRRAEQIAVLKEFVSCAQAAERAAYRRPDPWGDDEDGWMTQTGPVMTALWTASANVTLLCDEALRGPVTTYGHALNAAVWRDIGDVEVNEHLEEAKTAFMNEARASLAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNA3</accession>
    <name>A0A7K2ZNA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1365 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001450">
        <property type="protein sequence ID" value="MYW33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="PTHR33973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="27198" checksum="B35F5176A5714FCE" modified="2021-04-07" version="1">MSGAALYPCTITHVRTKPSKYALRHRTYLWLIDPDAPPRLPRTLRPLARFEARDHFGGTAPTIRAGLSRFLEARGVDLADGAVTMLTQARVLGHVFNPLTVYWCRRADGSPLCVVAEVHNTYGERHGYLLHPDAEHRATAGKEFYVSPFFPVDGGYRMRLPEPGDRLDLSVHLERDGARPFTATVRGTRRRATPRALARLALRHPLSTVAVSLAIRLHGIRLYLRGLPVQPRPQHRPQEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNF1</accession>
    <name>A0A7K2ZNF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Na+/H+ antiporter subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_32475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001487">
        <property type="protein sequence ID" value="MYW33860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="912"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="10">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="9">
        <location>
            <begin position="125"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="12">
        <location>
            <begin position="601"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="11">
        <location>
            <begin position="811"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="967" mass="101909" checksum="58E29EBBABBABDFC" modified="2021-04-07" version="1">MIGLIIGHFVLAAFAGPLVHRLGRRAFLVLALPPVAATVWAFTQWSTAASGEAVTWSWQWIPDYDVALDLRLDALSELMVLMAAGVGALVLIYCASYFRDNTPQLGRFAGNLLAFAGAMLALVLADDLITLYVFWELTTVFSFLLIGHGSEHRHSRRSALQALTVTTLGGLAMLVGFLIVGHAAGTYQISAIVADPPETTLAISVALVLILAGALSKSAIWPFSMWLPNAMAAPTPVSAYLHAAAMVKAGVYLVARLSPAFADAPVWKPVILVLGGATMLLGGWRALRLNDLKLVLAYGTVSQLGFLTLLAGTGNRNAALAAVAMILGHALFKAPLFLVTGIVDHSTGTRDLRKLSGVGRSLPYVAGVAVLAAASMAALPPLLGFAAKEAAFEALLHGSAADRWALAVVVLGSALTTAYTLRFVWGAFARKPGVPDTAVHSVGWAFLAPPALLALLGLVLGPGVGLTDRLFSAYADTYPAPEDPYHLALWHGFGIALLLSAVAWAAGTALFLARDTVTKVSRRIAWPTGDSVFGHLLLGQERLALQVTGTVQRGSLSVYLATTLLVMAGGQLAVFAVDQPWQGAPAPRIWDNELQGGVAALTCIAALLCLTVRRRMKAVVLSGIIGYGTALLFVVQGAPDLALTQFCVETVAMIVFVLVLRRMPVHFEETVSPWRRAVRIPVALVAAGVVGVSLWVAAGARTAEPAGAAMVKEVDDHGYKDVVATILVDLRAWDTLGESAVLAAAAIGVTSLIYLHRRSDGSMVPDELKGRTAWSIAAQHTARLPQGDEVAPERGWLAAGSTLAPEHRSIVFEVIARLLFHPILILSVYLLFCAENMPGGGFVAGLVAGVALITRYLAGGRFELAQAAPLQPGLFTGLGLFISTAVGLLGLIDGTVLHAFTYHGHLPVFGDFHMSTPILFDFGVYLLVLGVVLDIVRALGAKIDRQIERAAGALTASNSTTAEGNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNI7</accession>
    <name>A0A7K2ZNI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BlaI/MecI/CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001499">
        <property type="protein sequence ID" value="MYW33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16191" checksum="C3E02CB76045E23A" modified="2021-04-07" version="1">MDTEGAGGEREAPARRRGQGELEAQVLSVLGEATEPVTAAWVLERLGSGLSYSTVITILTRLHAKQAVTRTGRGRPVLWQPVANEAGLAALRMRSLLDKQSDRDAVLAGFVSVLSADDEELLRSLLAESEPGGGPGSGPGDGPGRPGAAPTDRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNK3</accession>
    <name>A0A7K2ZNK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_32465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001487">
        <property type="protein sequence ID" value="MYW33858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="114"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="288" mass="29892" checksum="8FD6DD5FC6B9A515" modified="2021-04-07" version="1">DVRAGRAVAAFALSEPGAGSDAGALSLTAEPAPGGWRLTGEKCWISNAPEADFATVFARTTPGAGSRGITAFLVPADRPGLTGQALDMLSPHPIGTLEFDGVPVTADDVLGEPDRGFRVAMDTLNLFRPSVGAFAVGMARAALDATVAHTATRTAFGGPLSDLQAVSHQVAEMATRTEAARLLVYAAAAAYDAGESGVPRRAAMAKLYATETAQYVVDTAVQLHGARALRRGHLLEHLYREVRAPRIYEGASEVQRAIIAKELYASAAAPEATAAPLPAAEETQESSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNV1</accession>
    <name>A0A7K2ZNV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001531">
        <property type="protein sequence ID" value="MYW34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029630869" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8311" checksum="F99D392CE27D5D72" modified="2021-04-07" version="1" fragment="single">MFMMSGTATVAAASLGLGGAPASAARISLPAQRRVGESEVDAVEQAVRRIRVLDDRHGADGLYRQASRPLKAAYELLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNZ6</accession>
    <name>A0A7K2ZNZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001542">
        <property type="protein sequence ID" value="MYW34094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="311" mass="33142" checksum="50D8D29D06E17DB9" modified="2021-04-07" version="1">MKAISYSAYGSADVLEYGERPDPKVGPDTVLVKVRAAAVNPVDWKAREGYLQGGLDAVFPVIPGWDVSGVVVQPGIAVDEFGVGDEVIGYVREDFLSRGTFAEYVAAPVRTLARKPLSLSFEEAAGLPLAGLTAYQVLHRTLKVRDGDTVLVHAAAGGVGSLAVQIARHNGCRVVGTASGRNHDHVRSLGAEPVEYGDGLADRLRELVPEGFDAAFDTVGGEALRVSAETLAEGGRLASIADSEVFSYGGRYAFVRPDAADLAQLAELAERGIVTVHVDRVFPLEQAAEAYRLNQEGRTRGKIVVRVDWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPQ5</accession>
    <name>A0A7K2ZPQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001584">
        <property type="protein sequence ID" value="MYW34239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15692" checksum="5D776FC3842FD749" modified="2021-04-07" version="1">MTAMDDLSTRPATAADLDTVLAFWKVSAEGTSISDDGDGVARLVERDPDALILAERDGTLVGTVIAGFDGWRCHLYRLAVHPEQRRKGVGGALLAAAEERFAALGGRRSDAMVLDRNDLAHHAWRAAGYGPQPQWSRWVKHLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQB6</accession>
    <name>A0A7K2ZQB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001625">
        <property type="protein sequence ID" value="MYW34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="20378" checksum="7F10CEBEE578B3E6" modified="2021-04-07" version="1">MIRLVRSSTLREMNAETVEMHNQATHEYGRAETLVVDVANVQALLEEERTAACDMGENLLRSQDLVETLEKDLAAARDDLARAQGELNVLRSQQLLDTEDRAALRALLRIARRQQARPDRVHVLYRYGRLHSVHSTRDDAEIAAEDEGADRAGWTSPSATDVAPNPNEIAWRIQPMALGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQG1</accession>
    <name>A0A7K2ZQG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001652">
        <property type="protein sequence ID" value="MYW34614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="389" mass="41347" checksum="9EB69AE3D3C67781" modified="2021-04-07" version="1">MPQIHGHCDDRFTGVRDAFEENFTTRGELGAAVTVLADGVPVVDLWGGWADRARTRPWERDTVVNVWSTGKGPTALCAHILADRGLLDLDAPVAAYWPEFAANGKGAVLVRHLLSHRSGVAGVGTPHTLDELYDWELTCARLAATAPMWEPGTRSGYHAISYGFLVGEVVRRVGGMLPGEFLRQEITGPLGIDFTFGLPEKKTHRLAELVQERADRDAQAALLARMTPVAVASLLNPPTGRAAANTPGWRAAEIPAANGHGTARAVAALYGILAGRGSLDGHRILSEQAVERVRESQGACRDLVLGDAFAHETEIALGLWLSGRNRSYGPDPRAMGHDGAGGSCGLADPEAGIALGYVMNRMGSGVADDPRKTALVNAVYTAVGDTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQI8</accession>
    <name>A0A7K2ZQI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001639">
        <property type="protein sequence ID" value="MYW34558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029896365" evidence="1">
        <location>
            <begin position="31"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="90"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="345" mass="36343" checksum="D600B8C7A540AC1C" modified="2021-04-07" version="1">MSLRPRPTAAVALAVAAALSLSACGSGDGGDTGKADAGGDKKAAVATGGKDFADAARKTAAYGTEAEPGRFPRTVTHAMGKSEIKAAPKRVVVLDVGEFDNVVSLGLKPVGYAPSEGDAAIPSYLEKGAGSPKSVGTINSLNLEAIAGLKPDLILGSQLRAADKYDELSKIAPTVFSIRPGFTWKENYLLNAAALDRTERAHSALAAYQAKAEKLGEDIGADKPAVSMVRYMPDRLRLYAKASFIGTILEDVGLPRPKNQQIDDLATEISPERIDEADADWIFTGVYGDAKATQRDTAQANPLWKKLDAVKEGRAKDVSDETWYLGLGVTAAGLVLDDLRADLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQQ2</accession>
    <name>A0A7K2ZQQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_36565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001670">
        <property type="protein sequence ID" value="MYW34647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="11818" checksum="603A4D985B80FB47" modified="2021-04-07" version="1" fragment="single">MVDAPWAQGKDRPVPYLVRAGADADDPDLVEVSWGGDTYEATADEFAELLAADTALARTELTVPVVLALPGPAADAAGLADLIARRLGRTVWWTGFPVDLSGTDDAGDPVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR58</accession>
    <name>A0A7K2ZR58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_37730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001706">
        <property type="protein sequence ID" value="MYW34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="161" mass="16421" checksum="4391E946554D8CD3" modified="2021-04-07" version="1">ALVLCVPVLGVLRLGDDDARALGVRVERARVAALGIAVVLIAPVVAVCGPVAWVGFLAPHLARRLRPDGGAAGWLVRSALCGAVVVLCADQPARLALAPVETPVGAWTALVGVPVGVVLLKRGRRAAKSGGQSRPALPGQGGPLGDRPVDDPVPLLRKAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR96</accession>
    <name>A0A7K2ZR96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001702">
        <property type="protein sequence ID" value="MYW34862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="83" mass="8551" checksum="85381F0D75A94465" modified="2021-04-07" version="1" fragment="single">MSSTTGTRGESVTPANPASDTVDQTTDVTALLERGRALSAPVLRAAVDRLAPPMDTVAAYHFGWIDAEGRPSDGDGGKAVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRC6</accession>
    <name>A0A7K2ZRC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BCCT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_37360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCCT transporter (TC 2.A.15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001689">
        <property type="protein sequence ID" value="MYW34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="578" mass="61279" checksum="1FC147B23F96C315" modified="2021-04-07" version="1">MSTENAPPPPGHPSHDPAESDAGPGPGTDSSPDRVVVAIGALGIIGIVLWAAFGKNSFESASDAALPWVLSNFAWLFVIAADVFLVLCLMIAFSRFGTIRLSRDDTPPEFSNFSWIAMMFSAGMGIGLIFYGVGEPVAHYLSPPPSSGAEPQSAGAASAAMEYSFFHWTLTPWAIYGIVGLALGYASFRQGRGNRLSAVFVPLIGARRANGVFGKVLDLLAVFATVFGTATSLGLGALQIAIGLDLTAGLDQSTGVQLVIIAVLSAAFVISAFTGLHGGVKWLSSINLVIAAALMVFVFVAGPTVYLMDVLPSSVGGYLDQLLPMASRTGAFGGESWLGMWTIFYWAWWLSWAPFVGTFIARISKGRTIREFLLAVLLVPSGATALWFVVLGGTGIRLAETGVVDMAEKSKEGTEATLFAMLDALPLSTVTAWVAMILIMMYFVTSADSASLVMGSLTSRGALHPRRWLVVTWGLLMAAVAAALLVAGGLESLQSATILVALPFVVVMLFLCWSLLRELRVDPGGGPKRSEGLHGMRDAVRVMVGEEMGNSPTSRHHRLRRAAAARANDSEEDRDTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRH5</accession>
    <name>A0A7K2ZRH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_37930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001723">
        <property type="protein sequence ID" value="MYW34907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="16464" checksum="689FBD6387927D07" modified="2021-04-07" version="1">FHRPRVAALAEAGPDVLALETVPDMDEAEAVVRVAEETGLPVWLSYSVAGGRTRAGQPLEEAFAVAVGREAVVAVGVNCCDPAEAEEAVRVAVEVTGKPAVVYPNSGEGWDAEGRGWTGASTFDPVRVRAWTGAGARLVGGCCRVGPDRIKELAGLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRQ3</accession>
    <name>A0A7K2ZRQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_38295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001735">
        <property type="protein sequence ID" value="MYW34977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009470">
        <property type="entry name" value="Chi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06483">
        <property type="entry name" value="ChiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029682653" evidence="5">
        <location>
            <begin position="34"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="73"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="703"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="712"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="787" mass="84410" checksum="59F93DF079389564" modified="2021-04-07" version="1">MLSPTRARATLLAAGAAVAGLLMTSLAATPSAAATDHESCRPDGLYKTPGVDTPYCTVYDGEGREKMGADHKRRVIGYFTNWRTGKDGKDAYLVPNIPWDKVTHLNYAFAHVDSSNKLSVGPDSADNASTGMTWPGVAGAEMDPTLPYKGHFNLLTKYKKLHPDVKTLVSVGGWAETGGYFGPDGKRVNSGGFYSMATNADGSVNQTGINTFADSAVTFIKKYGFNGVDIDYEYATSMKDAGNPMDHSLANGRRAGLVKGYDALMKTLREKLDRAGAADGKHYLLTVAAPSSGYLLRGMETYQMQKYLDYVNIMSYDLHGAWNEYVGPNAQLFDDGKDNELAQAGVYTTSQYGGVGYLNTDWAYHYFRGSMPAGRINIGLPYYTRGFKNVQGGTDGLWGKAATTTCPAGAGLTKCGDGAVGIDNLWHDKDDNGKESPAGSNPMWHAKNLEKGIAGDYLASYGFPANTQLTGTYVRKYDSTLVAPWLWNAQKKVFLSTEDEQSVKRKADYVVDKGIGGTMIWELAGDYQWNAAKGQYETGNTLTTAMYDAFKSAAPYGAKRSTVTLPTEAVNIDVSFNQFALGDSNYPISPKLKITNRTQATLPGGTEFQFDYSTSAPANAKDQSGFGTSIIRSDHTAANNIGGLKGPYNRVSLKLPAWQTVAPGASVELDFVYYLPTSTPSNWTVTFGGKSYALAGDLARGTKLVEPGTGTNPTPTPTPTPTGPTPTPTPTQPGGTCTAPAWNAATEYGGGSLVSQDGRTWKASWWTKGEKPGTTGEWGVWKDQGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS70</accession>
    <name>A0A7K2ZS70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001789">
        <property type="protein sequence ID" value="MYW35195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="104"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="319" mass="34704" checksum="9D29E15956EB5E96" modified="2021-04-07" version="1">MRTDIFARLDREPEPPKIVAPRMSRHRAALFGGTLAFYLAIVFAVLVTSWLVALDWKVMLFRPYQQWPELHAFLDYYVVLGQRGPTAVMVACWLGWRSWRQHTLRPLLVLGTALLLLNVTVGAVKLGLGRLGPHYATQIGSAEMFAGGDIFPSGHTANAVVTWGILAYLATTPRARRYLSAVSATVSLGVGLTTVYIGTHWLSDVVLGWAAGLLILLALPWFEPLIARAESWIFDVREQWRARRRAVRQVRAPGVVPQPVLLPQSIAAAEGAALAAGTGTPAAHPHPHLATGARARAHHVPTVCPERPQPAQAGPMTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSC8</accession>
    <name>A0A7K2ZSC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2236 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_39785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001825">
        <property type="protein sequence ID" value="MYW35253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="26685" checksum="704DE2AC305E2C99" modified="2021-04-07" version="1">TAREVRGYHASISGVDERGRPYHALNPGTFYWAHATFFMLTVQVAERFGGGLTEAQRHTLFDEHVRWYALYGLSMKPVPRSWEEFQRYWDHMCADILEDNRPTRDVLNMRRIAKPPLLRLLPSPLWAVARIPLVRLTLWVTIGLYPQAVRERLGLRWTPHDERLLRLLGRLIHHAWRRVPERHRFHPRARAGWDRERGRPVTGPVETPARNLPPEERRGLPQHYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSZ7</accession>
    <name>A0A7K2ZSZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001851">
        <property type="protein sequence ID" value="MYW35428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6547" checksum="78EE42D5ED3C8531" modified="2021-04-07" version="1">MHVLSPWREVVQVTGDGNPQQEGPKPVRTSLLTRAAEAARLMGGLAQAAYYALKTVLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z669</accession>
    <name>A0A7K2Z669_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000028">
        <property type="protein sequence ID" value="MYW27845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="31988" checksum="AE55E5818D66AEEA" modified="2021-04-07" version="1" fragment="single">MPAPTQPSKIRPQPKLYGEGAHRAQAPAMSHGPATAPPAGYRAVFAVTEFRAVFAAHLLSLLGVVVSELALTVLVYDLTGSPLLSALTFALGMLPYVIGGTLFAGVADRYPARRVLVVCDLVCAACVAVMLVPATPVAGLLALRCLVAAVAPVFTGTRMAALTDILGDGDLYVLGRSLLRIVSQSAMLIGFGTGGVLLTVLSPRGAITVTVVTFLCSAALLRFGTRDRPARAGGGSATLLKESLSGARLILGDRRIRALLLLLWLPAMFVVAPEALAAPYVAEIGAGPAALGLLLCAMAVGHVGAELFVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z695</accession>
    <name>A0A7K2Z695_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_00885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000035">
        <property type="protein sequence ID" value="MYW27861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="8328" checksum="4D7B4914476A4CF6" modified="2021-04-07" version="1" fragment="single">MTAAPLPPVAPEVTATLVEDLSPRLRKRLDAAVTKLGSRPTHRDGETVTIAVDDDTELRLHAPGGVVATVDAITCGCLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6K5</accession>
    <name>A0A7K2Z6K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_01470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01000063">
        <property type="protein sequence ID" value="MYW27975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514476.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000063.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW27975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="509" mass="56104" checksum="B00A8D0945061499" modified="2021-04-07" version="1">MSDDYLARIGKLIRDARQHRGWTQTQLAEALGTSQSAVNRIERGNQNISLEMIARIGEALDSEIVSLGYSGPMHLRVVGGRRLSGAIDVKTSKNACVALLCASLLNKGRTVLRRVARIEEVFRLLEVLNSIGVRTRWVNDGVDLEIVPPAQLEMEAIDADAARRTRSIIMFLGPLLHRMEQFTLPYAGGCDLGTRTIEPHMIALRRFGLEIAATEGLYHAQVDRSVSPGRPIVLTERGDTVTENALLAAARHDGTTVIRNASSNYMVQDLCFFLEALGVRVDGIGTTTLTVHGVPQIDVDVDYSPSEDPVEAMSLLAAAVVTESELTIRRVPIEFLEIELAVLEEMGVDCDRTPEYAADNARTRLVDLTVRPSKLEAPIDKIHPMPFPGLNIDNVPFFAAIAAAAHGQTLIHDWVYDNRAIYLTDLNRLGGRLQLLDPHRVLVEGPTRWRAAEMMCPPALRPAVVVLLAMMAAEGTSVLRNVYVINRGYEELAERLNSVGAQIEIFRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6M9</accession>
    <name>A0A7K2Z6M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000068">
        <property type="protein sequence ID" value="MYW27999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="31"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="117" mass="12852" checksum="0BEB5BFE11B162DD" modified="2021-04-07" version="1">RTRQTARCRVCRRPLTDPGEMKLMRCEECPSDMDEALYGRLLDWRAGQAARLSQPDYCVFTEKTLMAIAEAVPSTEGELVVIAGVGNRKLTRFGADVLAICAGETVGEEPEEGDGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6S3</accession>
    <name>A0A7K2Z6S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000079">
        <property type="protein sequence ID" value="MYW28045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="531" mass="56592" checksum="DC3DB2D0EB53A49C" modified="2021-04-07" version="1">MPAPEPSAPQPSAPHQPSAPARDRYDAVIVGGGHNGLVAAAYLARAGQSVLVLERLDTTGGAAVSTRPFAGVDARLSRYSYLVSLLPQKIVRDLGLDFAVRKRTVSSYTPAVRDGRPTGLLVGGDRTRESFAALTGGEREYEAWQRFYAMTQRVAERVFPTLTEPLPARDALRARIDDAEAWRTLFEEPIGVAVERNFTDDLVRGVVLTDALIGTFADAHDPSLLQNRCFLYHVIGGGTGDWDVPVGGMGALTDALARAARAAGAEIRVRHEATRIETDGTHAEVTVRTPDGEHVIAARRVLVNASPQALAALLGRTAPEPAEGAQLKVNMLLTRLPRLRDRSVDPRQAFAGTFHIAEGYGQLADAYRDAVAGRLPAAPPSEIYCHSLTDPSILGPDLAARGYQTLTLFGLHAPARLFAADNDAARAALLKATLAELDAHLEEPITDCLALDGNGEPCIEAKTPLDLERDLRLPGGHIFHRDLSFPYESETTGRWGVETPHANVLLCGAGAVRGGGVSGVPGHNAAMAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z712</accession>
    <name>A0A7K2Z712_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNHCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000104">
        <property type="protein sequence ID" value="MYW28139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024439">
        <property type="entry name" value="RNHCP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12647">
        <property type="entry name" value="RNHCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029601284" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RNHCP" evidence="2">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="12233" checksum="68906A0F0882C2B0" modified="2021-04-07" version="1">MSSLSAFTCVRCGLTVAASAPDGSRRNHCPSCLHSQHLVDHVEGGPSDCEGRMTPISIAVLRTGDWMVVHRCVRCDELTSNPVCGDDNQLILMRMAVRPLAQPPFPLEAFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7I1</accession>
    <name>A0A7K2Z7I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000138">
        <property type="protein sequence ID" value="MYW28265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="105" mass="11380" checksum="253B2CA2F14A4D5D" modified="2021-04-07" version="1" fragment="single">LGSPRLLALLALREAGGRAGLGDRTGCDRAIGRARAAFERGAAGGDPEWMSFFREAELELLEAQCWSALGDWSRAARHGRRAAALQDAHFTRNLALYRAQLTGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7L0</accession>
    <name>A0A7K2Z7L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="29575" checksum="159B8804CF6B3BFD" modified="2021-04-07" version="1">MAGVSTIKRGGSRFYVDPDDGRIKVPGVTSVVGMLPKDFLTYWAAKQSAEAAVSNWDIVSKLCERDPAGAIDYLKNAHRRTSKAASDLGSTAHDYFERLARGDNVPLRQVHADVKPHVTYFKQFLDEIQPEFLHLEETVWSDVHLYAGSFDAIAKVEGEVVVLDWKTSKEVYDSVALQLAAYRYADRIILSETGESIDVPPMTGGAVLHVRPDSWKFVPVECGEDVFAAFLALRKVFDWERDGKKGVVGRPIAKGGELETGTMRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
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    <name>A0A7K2Z7N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_03480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000146">
        <property type="protein sequence ID" value="MYW28357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="428" mass="44174" checksum="7702DE82D87167E3" modified="2021-04-07" version="1">MDKTAAPADAPPVGNPDAAEGAATVIDPRLLIREQGFGGYITEFKRKISGGDLGSIPVVVGLAIIAIVFQSMNSEFLSAKNISDIATTMVATGMMAVGIIFVLLLGEIDLSVGSVSGVSGALVAVLSVTQGMNEWLAILVAIVSGAVMGAIHGFFFARIGAPAFAVTLAGLLFWLGFMLQLLGDSGTINLDGDGVVGKLTTYYFSDVAAAYGLAAIAVIGYFAAAFLDTRRREAAGIPSRPIADIAVRTGVLAVFAFAAAYMFNQYRGLPLALVLFLIVLVGTDFLLRRTAYGRKIFALGGSVEASRRAGINVTAIRISVFSIAGTFAAIGGLFWASKIAAANQGSGTGDLLMNVIAAAVIGGTSLFGGRGRTWNALLGVMVIVSIQYGLSLEGIATPIQYMVTGAVLLATVVIDSVTRKTQKTAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7V0</accession>
    <name>A0A7K2Z7V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_03790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000159">
        <property type="protein sequence ID" value="MYW28416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="230"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="420" mass="42929" checksum="5991B93431D7D2AB" modified="2021-04-07" version="1">MPSPSPSSSAPPSVWRDADFRRLWAGQTASQLGEHTTLVVLPLFAVLALDAGAGQLGALRAVGQAPVLLFSLLAGAWVDRWRARTVMVLTDAARAVALGAAAVAGLFGLLGLPALFVAAFTVGALSVLFDVAYQASLVRLVRRDQLVQGNSALEGSRSAAQIGGPALGGALVSLLSAPVAVASGALFFAVSFASLRRIHRAEDVPEHPGPAPGVRHRIRDGLRFVTGHPLLRAVCLASAAFQFSLAATMTVYLLFLPRELHLSGATIGLALAATGPGALLGSLLAARLPRRYGHGVVLVSAAVLGNGALLWVPALHGSSAVTVAALLAVNFVFGAFGQLVNVTVMSVRQAVTPDGMQGRAAATITFAGLGSAPLGSLLGGFLAQGWGLRTSLLVTAAGMMLSPAVMAASPLVRLGRRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z823</accession>
    <name>A0A7K2Z823_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000180">
        <property type="protein sequence ID" value="MYW28472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="328" mass="33492" checksum="81C0524C4CA0F1C3" modified="2021-04-07" version="1" fragment="single">MRARTAVLCSVADQGVAALTNILVLLAAARLSTVADFARFSAVYLVFTVLLGVSGAYTGQPLVLKRGAGEETRGACRSAVAFTVLAAAALGALLAAVCLLVPGDTARALLMLGLVLPVVLGQDAVRYAFSTLQQPHLALLSDLLRLACVFGALGTQVYGASPARLIALWGLSALPALLLSAALLHRSTAGAPLLLRPMLRRGHLGQRFTVEFGVGNATSQLSVLGLGAVGNPLLVGALRGATTLFGPLNVLFTSATSFGPPLLGRIADERSRVRATAVLAAVLATTAGLWATVLALLPDSAGRQLLGDTWPVAAALLPATGSQYAAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8M4</accession>
    <name>A0A7K2Z8M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000241">
        <property type="protein sequence ID" value="MYW28681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6026" checksum="8BCC26563F0F0613" modified="2021-04-07" version="1" fragment="single">MVRSLADRGPAGAVRTAPPARHASPPVTGPEYFEAPADPASALPGPQLGEIPPQGASPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8P0</accession>
    <name>A0A7K2Z8P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_05300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000246">
        <property type="protein sequence ID" value="MYW28698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="386" mass="41098" checksum="7081BA22B5C28254" modified="2021-04-07" version="1">MKIGIVCPYSWDVPGGVQFHIRDLAEHLIGLGHTVSVLAPADDETPLPPYVVSAGRAVPVPYNGSVARLNFGLLSAARVRRWLHDGTFDVIHIHEPTSPSLGLLACWSAQGPIVATFHTSNPRSRAMIAAYPILQPALEKISARIAVSEYARRTLVEHLGGDAVVIPNGVDVGFFAKAEPKAEWQGGTLGFIGRIDEPRKGLPVLMKALPAILAAHPEARLLVAGRGDEEEAVASLPKELRERVEFLGMVSDEDKARLLRSVDVYVAPNTGGESFGIILVEALSAGAPVLASDLDAFAQVLDQGAAGDLFANEDADALAAAAIRLLGDPERRAGLRERGEAHVRRFDWATVGADILAVYETVTDGAASVAADERSGLRARFGLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8P5</accession>
    <name>A0A7K2Z8P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000247">
        <property type="protein sequence ID" value="MYW28719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="276"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="552" mass="59532" checksum="C869AAB38A539E0B" modified="2021-04-07" version="1">MAPTEATPQHEETAVADAVLEARSVSKRFPGVVALDDVSFSLRAGETHALVGENGAGKSTLIKVLTGVYRSDDGEVRVAGAPVSFSRPFEAQQAGISTIYQEVNLVPLMSVARNIFLGREPKNRFGLIDFGRMNRETTELLDGFGVRVDPKRPLHTLGIGTQQMVALARAVSVQAQVVIMDEPTSSLEPREVETLFRVIENLRGQGIAVLYVSHRMDELYRICDRVTVLRDGRHIHTGDLADLDRMRLVSMMLGRDLAEVRREGLTSFDAAGHDVARTPVLTATGLDRRHQLHDISLQLYGGEVLGLGGLLGSGRSETAKALTGALPLDGGEITVDGERIGRPTPAAAIRAGISMLPEDRKAEGIIPQLSVRENIVLAAMPRLSRAGIVSREKQDRIVDIFMERLRIKASSPEQKVGELSGGNQQKVLLARWLCLEPKVLLLDEPTRGIDVGAKAEVQSLIDDLAREGLAVLLISSDIEELIEGADRIVVLRGGAVAGELAGDEVAESRLLEVLADHTPTAVLPDHTPAAKPADHTPETGRKAPAAGQEDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z946</accession>
    <name>A0A7K2Z946_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000261">
        <property type="protein sequence ID" value="MYW28842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="2">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="200" mass="21665" checksum="707AC97B88327BCD" modified="2021-04-07" version="1">MLIPHDTRIALDTVVDLVNTAPESEPPDDGSGPTDGIVDEPEDGLADLPALYAFAERHHISGVGTLGEKDLGAVRDVRSRFAEVFAAPDARTAADLVNRLVAAAGTTPQLTDHDGYDWHVHYFAPDASLSDHLAADCGMALAFIIVAGEQERLRRCEAPDCGRAFVDLSRNRSRRYCSSRTCGNRLHVAAYRARRREAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z977</accession>
    <name>A0A7K2Z977_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000297">
        <property type="protein sequence ID" value="MYW28911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="160" mass="17763" checksum="DC4A74A894F90D84" modified="2021-04-07" version="1">MTTTTRSEDRNRDEGDNGKENSDDGYEIDTDPGRLDIDLVHHWLSTDAFWALGRSRDTVERSIGGSLNFGVYGPDGGQVAYARVVTDRATFAWLCDVYVAPAHRGRGLGARLASAVRDHLAPYELKRTMLATVDAHELYAKVGFVPVPDPELLMILSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9B7</accession>
    <name>A0A7K2Z9B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000298">
        <property type="protein sequence ID" value="MYW28922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="87"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="35745" checksum="2F92B5D4DBF494AB" modified="2021-04-07" version="1">MTDLPPPITPYLEPAAKELCEATDPHPRIYEVPPEKGRDILLGLQSDESVPRPEVDEEWVDVDAGRWGTVRTRIIRPKGATGQLPVVFYIHGAGWVFGDDKTHDRLFRELSVGAGAAGVFPVYDRAPEAKYPTQVEQNYAVGRWVLEHGAEHGLDTSRIAVTGESVGGCMSAVFALMNKERGGIDLKAQVLLYPVSNADFDTPSYLQFAEGYYLTRDGMKWFWDAYTSDPAQRTEVYAAPLQASLDQLRGLPTTLVITDEADVLRDEGESYANRLREAGVDVTSVRVAGMVHDFLLLDSLRDTRAANVARTLAVDALKKALHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9I6</accession>
    <name>A0A7K2Z9I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000311">
        <property type="protein sequence ID" value="MYW29016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="291" mass="32298" checksum="5DFA634F79A6BED6" modified="2021-04-07" version="1">ATDPAFDNRLLAPAIETYDRARQALAAAEDGLAADGRLGELSTAEREIRSLLAKVMLPTWDKVWQGLDLLRELPEGSRAEDRWTRDRWSFTAHRDRVTSGEPPQPRRDDAVTAAQKLASRETAQAQLEAQEALDDPLVLAGRRLAGEAFLADVTDVEMAYTESKRPSPRPLVTLRTDERPHLGERTKVYRSLDGKPQTAEFVRYAQEPDQEGEVLLVLRIMDRMGRGKEPAPGSLPEAGERIAWTLFEHDQRGGPKLPDPEETPWTHGGPPGADAATRAEHPDPVTPEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9J4</accession>
    <name>A0A7K2Z9J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_06870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000307">
        <property type="protein sequence ID" value="MYW29004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030572161.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000307.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="320" mass="33735" checksum="617C2353FD1F50A5" modified="2021-04-07" version="1">MELELRHLRTVRAIADTGSLTKAAATLGLAQPALSAQLRRIEKALGGTLFERDHTGARATPLGELVLERARVVLPAVSELQAEAVRFANATGPLERFRLGGTHGPLLGGLVDRIATAHPAAPVSTYTAWSVDEIAALTIDGRLDFALIGTCGESPPPLAERLVWEVVGVDPVFVMLPEDHPLADEEELDLASLADQCWADVPGDGCFADCFATACARAGFTPVSVYETDTSSVVHLVQVGRAIGLCRATFPPVPGVVTRPLAGAPLSWRHLLGWHPHSPAADAAAVAVAGQTRAAYAEAVSRSPVYARWLAGNPRFGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9M6</accession>
    <name>A0A7K2Z9M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000321">
        <property type="protein sequence ID" value="MYW29060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="96" mass="9658" checksum="92DC31041E53E3CE" modified="2021-04-07" version="1" fragment="single">MELGNPIDFTGRVAIVTGGTQGIGAVIAETFLAAGAEVMVCARTAPTTLPSSGGRHAAFHPTDVRDPAAAARLVAATAERFGRLDILVNNAGGSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9V3</accession>
    <name>A0A7K2Z9V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000345">
        <property type="protein sequence ID" value="MYW29108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="19186" checksum="A3E0A83EDAC0D18A" modified="2021-04-07" version="1">MPRTMSVADSIVIDAPPAHVYEQLSDPTAMGRWSPENRGATVEGERRGAYVGMVFEGRNKRGGVSWTTRCTVTAADPGERFAFRVHAIGVRRPRLPGPIATWEYRFEAVDGGTRVTETWTDDRRSWPDFLANGFDRVATRGKTFGQFQRGNIRTTLERLKAVVEEDLRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA50</accession>
    <name>A0A7K2ZA50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000373">
        <property type="protein sequence ID" value="MYW29251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="139" mass="15623" checksum="A7A7407DA9116F2A" modified="2021-04-07" version="1">MAARLVRHVDDTWTAAGRLLAATQAAPPGEVFTCDGITYRRVKTKHDSDRQRWNGTAPPRAENLTDGTRIHTAQAEDTAFWTWAITHALRLTGVRIEELLELSHLSIRQYQRPNGEVRRFRSCSNATATAPAAASRRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAF0</accession>
    <name>A0A7K2ZAF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_08555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000402">
        <property type="protein sequence ID" value="MYW29326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="190"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW29326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="421" mass="45188" checksum="7C7AFBCBB7C4D3F2" modified="2021-04-07" version="1">MKLAVVGGGSTYTPELIDGFARLRDTLPVEELVLVDPAADRLELVGGLARRIFAKQDHAGKITTTTDLDAGVAGADAVLLQLRVGGQAARNQDETWPLECGCVGQETTGAGGLAKALRTVPVVLDIAERVRRTNPDAWIIDFTNPVGIVTRALLQAGHKAVGLCNVAIGFQRKFARLLDVNPSEVHLDHVGLNHLTWELGVRLGGPDGENVLPKLLAEHGDAIADDLHMPRQIVDRLGVVPSYYLRYFYAHDEVVRELGTKPSRAAEVAAMEKELLAMYGDPTLDEKPELLAKRGGAFYSEAAVDLAASLLGGGGSPVQVVNTYNNGTLPFLPDDAVIEVQARVGHEGATPLAVPALDPLYAGLIANVTAYEDLALEAALRGGRDRVFKALLAHPLIGQYEYAEQLTDRLIAHNREHLAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAK5</accession>
    <name>A0A7K2ZAK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin biosynthesis protein CobG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000407">
        <property type="protein sequence ID" value="MYW29386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="17770" checksum="B347164E26620484" modified="2021-04-07" version="1">APGLVGTAAITADVPLGRLTPTQWQLLTDTARRYGGELRLTPWRGIVIPGPVPRPEVSEALRTLSASGLITAPDSPWTGVGACIGHPGCAKSLSDVRAEAGAAVGVPGRLPVYWSGCERRCGHPHGEWIDVVVTPDGHRISHVRGERRDPPTTVGNDSARLAAAVAEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAL9</accession>
    <name>A0A7K2ZAL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000410">
        <property type="protein sequence ID" value="MYW29400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="244" mass="26903" checksum="643690594E50047D" modified="2021-04-07" version="1">MTQQPLEPLPADWSRALAVVAHPDDLEYGAAAAVADWTDGGREVVYLLASRGEAGIDTLPPEKCAPLREREQRASAAVVGVRTVEFLDHRDGVIEYGTGLRRDIAAAIRRHRPELVVTLNHRDTWGGTAWNTPDHRAVGRATLDAVADAGNRWIFPELKEQGLEPWDGVRWTAVAGSDRPTHAVDATAGFERSVESLLAHRTYIEALSEEEPETYCRTFLEGMVRAEADRFGGRPAVTFEVFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAM1</accession>
    <name>A0A7K2ZAM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000406">
        <property type="protein sequence ID" value="MYW29383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="343" mass="35749" checksum="68319B074131BF0D" modified="2021-04-07" version="1">MPAGVETSDDGGSTALAVRRAADRFIRFVDAVTAGTVEAPLPGGGRTSARFDVLSAVAEDDLCAARLAEGHLDAVAILAELDGDPVAPGEYWGVWAAEPPGSGLTATRGPDGWVLNGLKQYCSGAHSCTHALVTATAEDGRRLFAVRTNIPEVEAGTGCAPVPGTWRAIGMAGSDSPDIRFTDVPATPVGGVEAYLRRPGFHHGGVGVAACWYGGARAVSRVLFTRAEQRADPFTDAHAGAVDLRLYTAGTVLRRAAEEIDLDPLDKAGTAGLRTLRVRALVAEVCSEVLDHVGRATGAGPLCHDERHARAVTDLGVYVRQHHAERDLAALGGLVARGPEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB18</accession>
    <name>A0A7K2ZB18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="6" type="ORF">GT040_09610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000448">
        <property type="protein sequence ID" value="MYW29524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018516257.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000448.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="18217" checksum="6DD4CE9BD6BC6D26" modified="2021-04-07" version="1">MRSPVDVLIRLLDPEVPIPAYGHPGDAGADLVTTEAAELAPGERVVLPTGVSIALPDGYAAFVHPRSGLAARCGVALVNAPGTVDAGYRGEIKVIVVNLDPRESVRFERFDRIAQLVVQQVEKVRFHEVAELPGSARAEGGFGSTGGHASVDVAEGGITHGGNSYASVVSDREGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB76</accession>
    <name>A0A7K2ZB76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite reductase small subunit NirD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nirD</name>
        <name evidence="6" type="ORF">GT040_09920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000457">
        <property type="protein sequence ID" value="MYW29583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017881">
        <property type="entry name" value="NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40562">
        <property type="entry name" value="PTHR40562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12145" checksum="C4DA3694FCAA4EDD" modified="2021-04-07" version="1">MTTETLNTTVVRVAHADGWLTVCDLELLSPGRGVAVLLPDGGQAALFRDRAGVVRAISNRDPFTGAYVLSRGLLGSAGGRPFVASPLLKQRFDLTTGVCLDDEDASVAVYAVRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBA3</accession>
    <name>A0A7K2ZBA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000461">
        <property type="protein sequence ID" value="MYW29614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="304" mass="32896" checksum="D6B8BA7998E8ED17" modified="2021-04-07" version="1">RIEDLAHASGATVRTIRAYQDRGLLPTPERRGRANVYGEAHLARLLRIADLLERGYTLASIKELLEAWDAGRGLGGVLGLVAEVHGPWTDEEADRITREELDARFGGSQDDEAIAEAVELGVLERVPGKADEFLVPSPQELAVAVELHAAGVPLLAISGHLKELRGQVEHIASRFLEFTTEHVFARYLGHRPPTDSDAAEAASMVRRLRPLAQQTVDAELARAMRMFATRHLHHHLGSPESVIEGSEARPVLLPASTTQAVQDLVGADQVAAFVAAAAEREVQARTLDALASSHSIANKVDEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBA6</accession>
    <name>A0A7K2ZBA6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ORF">GT040_10070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000461">
        <property type="protein sequence ID" value="MYW29613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="180" mass="19886" checksum="9C8161C8649C0326" modified="2021-04-07" version="1">MDERRTVKVSKYLSKHLRHEPGRIGVTLDDNGWVGVETLLGAAARHGFAITRAELDHVVAANDKRRFTVDGDRIRANQGHTVTVDLDLPPAEPPAYLYHGTVARVLDAIRAEGLRPMARHHVHLSPDRETATRVGARRGRPLVLTVDAGAMHRAGHVFRVSANGVWLADAVPPEFLLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBG4</accession>
    <name>A0A7K2ZBG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000478">
        <property type="protein sequence ID" value="MYW29673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029884332" evidence="2">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="15878" checksum="DE5F3B04C3D32431" modified="2021-04-07" version="1">SAGDRRRAGLRCAFVALLTAAALVLPAAWRDPGAFHAHVIAFPLGLTDAVSSAASPLPGHLLATHAPGGRTLALGLLGASALLVAVSLLVRPPATAPDAALRLAVGLLLAIAFLPATRFGYLVHPLVLAVWAAVVRQRPVDSPVFVRIQKKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBM1</accession>
    <name>A0A7K2ZBM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidylprolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_10690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000490">
        <property type="protein sequence ID" value="MYW29733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="103"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="264" mass="27765" checksum="31DA9E0D409C0C45" modified="2021-04-07" version="1">MSSSEQRRRQLAREKFERQQKRREEARLRTRRITAIVAASVAVVAVVGVSAFVVAGRDDGKDDNKTEAAASQSPEPTPSESESKAPLPPMKIDKKATYTMSLGTSQGEMAFAMDAAKTPQTVNSFKALADKGYFDGTKCHRLTTQGIFVLQCGDPKGDGTGGPGYNIPDENLTALGEAGADGTVTFPAGTVAMANTGQPGTGGSQFFLVYKDTKLPPTYTPFGKLDKDSLKNVEKVGAAGVEGGAGDGAPKKAVEIEKASVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBT8</accession>
    <name>A0A7K2ZBT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_11195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000506">
        <property type="protein sequence ID" value="MYW29831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="413" mass="42427" checksum="0EFA40CC0870169A" modified="2021-04-07" version="1" fragment="single">MPDALPDDLAGAVTAAAAEGVLGRTFRALSIGIVSVVFLIAFEATAVGTAMPVAARELHGIPLYAFAFSAYFTTSLFAMVLSGQWADRRGPLQPLATGITAFGAGLLLSGAAGSMWVFIAGRAVQGLGGGLVIVALYVVIGRAYPERIRPAIMAAFAASWVIPSVVGPLAAGTVTEHLGWRWVFVGIPALIVIPLALALPQIRRMASGPADPDAPPPPYDRRRIRLALGISAGAGLLQYAGQELNWLAVLPAAAGVALLVPAVRGLLPTGTVRAARGLPSVILLRGVAAGSFIAAESFVPLMLVTQRGLTPTMAGLSLAVGGATWALGSYIQSRPRLEPHRERLMVSGMVLVAASIAVAPTVLIPAVPVWIVAVAWAFGCFGMGMVIASTSVLLLKLSAPEEAGSNSAALQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBW1</accession>
    <name>A0A7K2ZBW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_11215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000506">
        <property type="protein sequence ID" value="MYW29834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="781" mass="84353" checksum="BAD2579EDC33C8BD" modified="2021-04-07" version="1">MLSYRDIVDAPTGKLKAAADDWSEMAQKLERLATQAADGLKTKADKADWEGLNAGVTKAFIGKTAKEFADAAAQAKGVKMILEDGLAAIKKAKDDLTGIRDHEGPAAGIRVDAEGKVSARRPLADAPPAQRHDPDYPQLVRQENQNIAAWQKKIDLIVDNCNDADVSLKNALEANVTDRKDFSAPKYTKLDQEEAARAAALAAKGRDLTHTQLQALNELLRDNSKSVEFSKNFYEKLGPEKSLSLFGQLATDTHRGMKVDEERLKDVRALQKNLGLNLATASYDKAFSAEWGPELRKLGTQQIPLTKYDTAGDPYGYQLLGGIMRYGKYDARFLNPIAEHVAQLHQKDPYRFADNKQVHSFLGSPFNPSGKNGSGYDPVTAMLEALGNSPDAAKRFFTDDPTAYNEDGTVDKGATADLGKQDGEAIDNYLDFFGNEKWESFPDMASTDPNKLEATRQYMPDALGHALEAATLGYPAGHPDASVVRDADNAAVMRQVMEKYGEDAGLLKKQEGMADSLGIMGAGYIDDINWALDKGSADSVFAPAENREGHVSFDGEEEEGRSAARRFLSALGQHPDAYATLSAAEQAYTRSVLEAQVGSDGKIDMGSARSTIHVGSEVQGMLDQSRADQVAANHMKTHEDFEKAVAKRAGWVEFGAAAGIAAGVAFLPATAAVGAAAVLIPLATDTASGAAEQVIGQFVGDISDNSVDKSKEKAEDLTEGDWNRIYRSGEAMAEAPMEEFLARHTTKEDSGFRQDMKESMRSGYSTGNDRENQQGASPETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBX9</accession>
    <name>A0A7K2ZBX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_11315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000511">
        <property type="protein sequence ID" value="MYW29854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="AlcB" evidence="8">
        <location>
            <begin position="681"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="848" mass="91398" checksum="D7B84B5FE8D1D18A" modified="2021-04-07" version="1">ARLADTARRCYDRLAPETAAWVSAYVDGVNAVLADGAARAPEFAAAGLTPGRWEPWTPLGVWLSTHILFAGFPTKLWREEVSRRLGADRATLFATDGPGTSGSNGWLLTGARTTTGAPVIAGDPHRFIEDPGVYQQIRLACPEFDVVGLAVPGVPGIAHFGHAGGVAWAITNAMADYQDLYREQLRRTADGGVEALGPDGWYAVHAHTETVEVAGGEPETVEVVETDRGPVIIGDVRDDPHTDATPDAPVISLRHPPRVTGGLGFDVLPALLRARTVADLDTALDGWVEPVNVVLAADTTGATLHRVAGHVPVRPHENRLRVVPAHDPAYAWREGAEPTPRTEVDAATGTAVMANERGLAAPLGIEFAPPHRARRIRELLGTPPGSGARKLTGPPWSSADMAAVHTDTRLASSRQLLSLLAWAPDLGPDAERLRNRLLLWDRHVDAHSADATLYSRLRADVVHRLAAHPALRPVTGDADPWRSAAYPPLFRPWLAAVPRIGYALETLLTVGLLPYEDRLAIVAASAEAVAATEAESPWGQVHRVSPWQALPGAASEEVWPGVAGDHDCVLSTSSVPGITDLFARGPAARYVWDLARREDSLWVVPFGASGVPGSAHHRDQSELWASGRLAPVTTDWNLLHRTEESTTTMTTTPEPTVSTVPALRPAVHEQKVEGFGVVRLVPVDPAADAELLHGWVTEERARFWGMADHTREQVREIYEFVRSLPTHHAYLALRDGVPAALFQTYEPDADPVGECYDVQPGDFGIHLLIAPAEGEGAVKGYTDALLTAFIGYVFSDPAHLRVVVEPDARNEKALARMVRVGFELGPEIRKPEKTARLAFLTRAALGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCK8</accession>
    <name>A0A7K2ZCK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000583">
        <property type="protein sequence ID" value="MYW30069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04863">
        <property type="entry name" value="MtLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033649">
        <property type="entry name" value="MtLigD_Pol-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="32568" checksum="A1C7ACF1DE0D9EFC" modified="2021-04-07" version="1">MTPITEVEGRRLSLSNLDKVLYPATGTTKGEVLLYYAATAAGAILPHLRDRPVSFLRYPDGPGGQLFFTKNPPPGTPDWVRTTPVPRSEDPAARQVMVQDLPALMWAANLVVEFHTPQWRAKEPEIADRMVFDLDPGSPATVVECCAVALWLRERLAADGLFAYGKTSGSKGLHLLVPLEPAPSAEVSAYAKRLAVEAESALPGLALHRMKRALRPGKVFVDFSQNSASKTTATPYTLRARPEPTVSAPVTWDEIEGCREPEALVFRAEDVAGRLERYGDLLAPLLDPERARPLPAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCN4</accession>
    <name>A0A7K2ZCN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.97</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uraD</name>
        <name evidence="4" type="ORF">GT040_12630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017595">
        <property type="entry name" value="OHCU_decarboxylase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03180">
        <property type="entry name" value="UraD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="3">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="19023" checksum="29FE3F6D2C7FFAA9" modified="2021-04-07" version="1">MTSSSTPGLTRFNTLADGEATPALHEVCASAAWGETVLAGRPYATEEALLSASDAAMAELTAEDLAEAMAGHPPIGRPKPGDPTSSREQRGMAGASEELKTEMLELNLAYQERFGHVFLICATGATGEQMRDAVKSRIGNSPEQEQEIVRTELGKINRIRLTRLVRETLAEVAPAQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCR0</accession>
    <name>A0A7K2ZCR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="17167" checksum="76EA77874C3A7A2E" modified="2021-04-07" version="1">MGYTTEFTGFVTVSPPLNPAEIAYLDKFADTRRMARKLGPYFVDGSGPFGQGQDADIVNYNRPPEGQPGLWCKWEPTPDGTAIRWNGAEKFYDADTWMAYLIDHFLQPGGKAQGQPGFEDFTFDHVVNGEIKAQGEEPDDTWTLHVTSNAVTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCR9</accession>
    <name>A0A7K2ZCR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000599">
        <property type="protein sequence ID" value="MYW30146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_22" evidence="1">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="14008" checksum="0229A3779EA9F4C0" modified="2021-04-07" version="1">MTESADHVPVTVDHPFVSAVKPLVDAMGAELLGPEQAQPDDVVLAWEGQDVIAVRLPQLSDSLDHILAALERRHGMPLADLDRKAKQSVVRTLEARGAFSVRHGVETVAGALGVSRFTVYNYLNREKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCY3</accession>
    <name>A0A7K2ZCY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000605">
        <property type="protein sequence ID" value="MYW30182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="472" mass="51817" checksum="CB70E7A1D0DDB985" modified="2021-04-07" version="1">MRDPLSALSDAFTAFLFGKVETTRLPVRTSTGQAQAVYLPTAAPGLGDSGVIIGREVYSGKGYIYDPFQLYGQQLPAPHWLVLGESGNGKSALEKTYVLRQLRFRDRQVVVLDAQGEDGVGEWNLIAQELGITPIRLDPTAALNGGIRLNPLDPSITTTGQLALLRTIIEVAMGHGLDERSGFALKVAHAYVTATNTDRQPVLMDIVEQLRHPKPESAEAMNVDIDDVRAWGLDVALVLDRLVDGDLRGMFDGPTTVGIDLDAPLIVFDLSHIDRNSIAMPILMAIVGVWLEHTWIRPDRKKRIFLVEEAWHIINSPFVAQLFQRLLKFGRRLGLSFVAVVHHLSDVVDGAAAKEAAAILKMASTRTIYAQKSDEARATGRVIGLPRWAVEIIPTLTPGIAVWDVNGNVQVVKHLITEAERPLVFTDRAMTEGSSDDLLPEDIRAAELEAEQRAARIENQQRIDDSSRSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCZ6</accession>
    <name>A0A7K2ZCZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000620">
        <property type="protein sequence ID" value="MYW30251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="173" mass="17842" checksum="4F203AD200931D3A" modified="2021-04-07" version="1" fragment="single">MSDQQWQPFGPRPPGPRMPTGPSHSPHSPYPAGPAHPSGPAYLSGPGQPPGPGYPGAPGGPTGPEPPFGGEPEGSEHDAAAAYVLGILDDAQASAFEAHLAGCARCSAHLDEFAGMEPMLAMLAEAPAAAPGARPVPHVPERPAPKVLGGLMDEVAHRRHRRTRRSRYLIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD40</accession>
    <name>A0A7K2ZD40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_13450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000629">
        <property type="protein sequence ID" value="MYW30266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="98"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17173" checksum="543FF6A28D70EA24" modified="2021-04-07" version="1">TVDEAVESCPAPALRGGNRHGVLVAAQSVSPDGVLRAVRAGARTILRTTDATPEQLVAAVHSAHHGDGRLPYGVLVRLLGASQQSGPEPATALPDTPRTARTAPLTPRQTAVLTLVAEGHGNAVIAQALSCSEHTVKNVIYELMARLQVRNRAHAVARAVRAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD98</accession>
    <name>A0A7K2ZD98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ORF">GT040_13790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000654">
        <property type="protein sequence ID" value="MYW30331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512155.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000654.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="213"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW30331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="510" mass="57238" checksum="15757DAD34CF2941" modified="2021-04-07" version="1">MSAVPGANPLRDAQDRRLPRIAGPSGLVIFGVTGDLSRKKLMPAVYDLANRGLLPPGFSLIGFARRDWEDEDFAQVVHDAVKEHARTPFREEVWQQLIQGMRFVQGNFDDDEAFETLKATIQELDKAQGTGGNFAFYLSVPPKFFPKVVQQLKKHGLADQKEGSWRRAVIEKPFGHDLASAQELNQLVHDVFPPNEVFRIDHYLGKETVQNILALRFANTMWEPIWNRSYVDHVQITMAEDIGIGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPGSFHPKALVAEKLKVLTAVELPEDLGLHTVRAQYEHAWQGGQEVLGYCEEEGIDPKSTTDTFAAIKLTINNRRWAGVPFYLRTGKRLGRRVTEIAVVFKRAPYLPFESGATEELGGNALVIRVQPDEGVTVRFGSKVPGTSMEVRDVTMDFAYGESFTESSPEAYERLLLDVLLGDANLFPRHQEVELSWTILDPIEEYWDKHGKPAKYAAGTWGPAEADEMLARDGRSWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDF0</accession>
    <name>A0A7K2ZDF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMP-30/gluconolactonase/LRE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000655">
        <property type="protein sequence ID" value="MYW30338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="57"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="332" mass="34842" checksum="848ED8A9FAECD98C" modified="2021-04-07" version="1">MLAIAFAFAIAGCGTESGAPGGLSAPGATTATTATIRAQKVMRLTRTHEETGMTLLEGPAFHPDGGLFVVDVTAPPGKPKVMRVDVRRKTVRPVHTDGRGAYTSAQFSPYDGRLYLTDYAHGEIVSLAPDGGDPRTFFAGEVDGARMNPDDIAFDEKGHLYVSDSRGLSEGAAHGRVVRIDREGGKVTVLADGMAATNGISFDEAYRGLWISELTENRISYLRLGEGGEAASRHTAIRVDGGIAQTDSIAVDADGNLYQGLHGRPAIVVYDRHGERLATVEVPARAEGLESATNVAITPGGTRAYMTVSGPGGGYLYTFDALGKGTRQSNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEC6</accession>
    <name>A0A7K2ZEC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000730">
        <property type="protein sequence ID" value="MYW30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029542186" evidence="1">
        <location>
            <begin position="33"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="436" mass="46719" checksum="92B9FB8D092AD027" modified="2021-04-07" version="1">MPIARAAKRATVRLGAVVLAGALLAACGSGSGDSSDTSDSAGGKVTLTVDLFGSFGFKEAGLYDEYQKLHPNVTIKQSDTQDEADYWKSLQTRLAGGGGLADVQGVEVGRIASVTQQQSDKFQDLKEFGADKLKGEFAEAKWSAATTKDGKVLGLGTDVGPEAMCYRTDLFKKAGLPTDREELAKKWSTWDGYLELGKEYKKKAPAKSAWLDSIGSLYGIMIGQEEERYYNASGELIYEKNPAVKTAWDTSVKAAEADLSAKLDQWSPQWNQAFAAGSFATIPCPAWMLGYIKGQAGDGGQGKWDIAKLPGGAGNWGGSYLSIPRAAKHKEEAYKLIEWLTAPEQQAKVFQKQGNFPSSTGAIEKIADAKDDYFSGAPIGQIFGDAAKESPVQVLGVHDQNVMQQLTNALSEVERKGVSSDKAWETAKKGVANVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEL8</accession>
    <name>A0A7K2ZEL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">GT040_16355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01000763">
        <property type="protein sequence ID" value="MYW30804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="212"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="375" mass="39152" checksum="79EF1565F3FF76C9" modified="2021-04-07" version="1">MTGARRIVVKVGSSSLTTASGGLDADRVDALVDVLAKVRDGGEREVVLVSSGAIAAGLAPLGLVRRPKDLARQQAAASVGQGLLVARYTASFARYGVRVGQVLLTADDTSRRAHYRNAYSTLDKLLEMGAVPVVNENDTVATDEIRFGDNDRLAALVAHLVHADLLVLLSDVDGLYDGPPGTPGASRIAEVTGPDDLAGVTIGSAGKAGVGTGGMVTKVEAARIATAAGVPVVLTSASRAADALAGRDTGTYFHRTGRRSADRLLWLAHASTPQGALTLDDGAVRAVVERRTSLLPAGISAVEGEFSAGDPVELRDPRGTPVARGLVNFDAKEIPQLLGRSTRDLARELGPAYEREVVHRDDLVILTPRRTPWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEQ4</accession>
    <name>A0A7K2ZEQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000767">
        <property type="protein sequence ID" value="MYW30831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="261" mass="28420" checksum="D604EFE64F6873D1" modified="2021-04-07" version="1">MSVDDVEFRRRIRSDVPHSARVWNAWLGGKDNYPVDRELADAVSAAYPQMVDIARASRAFQARAIRHLASLGIRQFLDVGTGLPVANSTHEVAQGIAPDARIVYVDNDPIVLAHAHALLTSAPEGRTEYVEADLSDTDTVVDAAAKTLDLSEPVAVLLLSTLGHLTPADGIDVVQRYMARMPSGSYLVLCDTVKTPQTLAAQEAYDSGENPPYLVREPEEITGCAEGLEIIEPGFLSIALWRPEEDDPVLVDQWGLVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEQ6</accession>
    <name>A0A7K2ZEQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000762">
        <property type="protein sequence ID" value="MYW30798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="113" mass="11595" checksum="FBC8C00EDCEA0189" modified="2021-04-07" version="1">MAQAIRAQAAVSWGVYMASSATENAPPIASPAVAAVGHEDSAIAGQEQQQVEAAVDDGGLPAGRGGKEEAGRRQDDQAGVEEDQVAAPAVEQWVPGAFLEGGQNLIEDQADQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZER1</accession>
    <name>A0A7K2ZER1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6458 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000769">
        <property type="protein sequence ID" value="MYW30857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030563210.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000769.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045597">
        <property type="entry name" value="DUF6458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20059">
        <property type="entry name" value="DUF6458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6458" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="73" mass="8038" checksum="CA8A5366F9E956FF" modified="2021-04-07" version="1">MGLGGCILLIGGGAILAFATDWKVDTVNVDLVGWIMMLVGLIGVFVYMSIARRRRMVVPPTTTVVQDDEQRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF15</accession>
    <name>A0A7K2ZF15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000801">
        <property type="protein sequence ID" value="MYW30922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="85" mass="8649" checksum="79F78ECF4FE69E1A" modified="2021-04-07" version="1" fragment="single">ALVLSGARLTDGRAVDVRLSGSRIEAVGTAGSLTARGPRIDLRGYLLLPAPAEPHAHGDTALTADGAGPASDHPEDIQRRATEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF20</accession>
    <name>A0A7K2ZF20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_16855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000784">
        <property type="protein sequence ID" value="MYW30899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="295" mass="32040" checksum="531561EA3186C340" modified="2021-04-07" version="1" fragment="single">ALAAAVGVIGVAAGADRVRWHRTRYRIGEERVDLHTGLLLVKRRSLARERIRTVDLTANPLLRLLGLVTVRIGTGEHGGDSTLELDPVARAEGERLRRRLLERATTPRPGEHRDGELATLDPRWIRYAPVSFVAPMLGGAAIGAVMQISEWVGAQGEVIAWVGDRFQETPLLWVIVTLVAAALAAGVVGALGLWIEMWWNYRLEREPGGTIRVRRGLFTSRSISVEEARLRGVDLVEPLGVRLVGAARLDAITTGLAQDDESKNADHNTVLPAVPRPLADSVAAAILREEATPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFE2</accession>
    <name>A0A7K2ZFE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_17560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000820">
        <property type="protein sequence ID" value="MYW31038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="755" mass="83276" checksum="9D7578E12E8A5C4D" modified="2021-04-07" version="1">MQLAAIIVSLVLTVVGVALITRAVAQIYRFVRLGQPVPAGSRTDDPKARTITLVKEFLGHTRMNRWGIVGFAHWFVAIGFLTLPPTLLQAYGQLFQADWVLPVIGNFLPFEMYIEFIGLMTVVGIVALMAIRLLNLPSRAGRKSRFAGSKAWQAYFVEYIILIIGLAILTLRGLEGAIHHVDSYGAAYFVSYPLVLAFKGLSVSTLQTLIYLTAMIKIGTSLIWMITVSLNTNMGVAWHRFLGFPNIWFKRNADGDVALGALQPMTTGGKEIDWEDPAEDAVFGVSQVEQFSWKGILDFSTCTECGRCQSQCPAWNTGKPLSPKLLIMSLRDHAHAKAPYLLAGGGKDMEGNEKATEEQLKDVPAAALAEAERPLIGTAEENGVIDPDVLWSCTTCGACVEQCPVDIEHIDHIVDMRRYQVMIESAFPSEAGTMLKNLEKKGNPWGLAKKARVEWTKEVDFEVPIVGKDVEDLTEVDYLYWVGCAGALEDRAKKTTKAFAELLHIAGVKFAIMGGDEKCTGDSARRLGNEPLFQQLGQENVAMLNMAYGEDDDEPETKKPKSSKKIVATCPHCFNTIANEYPQLGGEYEVIHHTQLLQHLIDEGKLIPVTPVEGLITYHDPCYLGRHNKIYTPPREIIAKVPGLRNEEMHRHKERGFCCGAGGARMWMEERIGKRVNNERVDEALALNPDIVSTACPFCLVMLTDSVNGKKNDGQAKESIQVVDVSQLLLESVKTPADPAGEPEQVDAPEPEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFF9</accession>
    <name>A0A7K2ZFF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_17895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000853">
        <property type="protein sequence ID" value="MYW31104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8617" checksum="A3EC8A57AA2F17BD" modified="2021-04-07" version="1" fragment="single">RGGDRPEDRGESERLAAGFVRGDEDSFALVYRRWGALVHSLAARSLGDAREAEDVAQQTFLAAWRGRHGYHAVRGPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFH2</accession>
    <name>A0A7K2ZFH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate--cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_17615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000823">
        <property type="protein sequence ID" value="MYW31049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="501" mass="55667" checksum="AC3A78EA2130D298" modified="2021-04-07" version="1">MGEKVVAGAVDLSDRQAYRTKLNQCLEGLGRLLAERRFDRPRNLMGLEIELNLAGSDGLPRMMNQEVLQRIASRDFQTELGMFNLEVNIVPHRLGGRVFDQLSEELRTGLAYAHRKAGEVDAGIVMIGILPTLGEHDVVSANLSDVDRYTLLNDQMAAARGEDFVLDIEGVDHLVCSSPSIAPESACTSVQLHLQVTPARFADVWNAAQAIAAVQIALGANAPFLFGKELWRESRPPLFQQATDVRPPELANQGVRPRTWFGERWIDSAYELFEENLRYFPPLLPICDDEEPLRVLDEGGVPELAELVLHNGTVYRWNRPVYEVADGVPHLRVENRVLPAGPTVTDVIANSAFYYGLVRALAEESRPVWSMLPFEAAAENFTEACRHGIDAELLWPRPGRAGQLARIPAVQLVQEELLPLAAAGLDAWQIEPVDRDRYLGVIEERCKRRVNGASWQVATYRRALEAGLGREAALAATTRRYAELMHAGEPVHTWPVGFPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFI4</accession>
    <name>A0A7K2ZFI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000827">
        <property type="protein sequence ID" value="MYW31059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="22021" checksum="528149A15AF26542" modified="2021-04-07" version="1" fragment="single">MRCELATAPGDPERPNEDWASAAAPASGQGGVVVVLDGVTPPEGNDGCVHSVPWFTARLGGALVELSGSRRDMDLAEILSESIRRTADAHRSTCDLSHARTPQATVALARWGEHAIEYLVLSDAVLLLEGADGAVRAVLDDRLDRLPPGSLASAATVDGRLRNKEGGFFTAAADPEVAARTVTGTVPADQVRSLAALTDGASRWAEVFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFJ3</accession>
    <name>A0A7K2ZFJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_17715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000832">
        <property type="protein sequence ID" value="MYW31069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512479.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000832.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="16638" checksum="2A153D635BF47838" modified="2021-04-07" version="1">MRLNDLDERIVHALAEDARRSYADIGAIVGLSAPAVKRRVDRLRAEGAITGFTVRVDPAALGWETEGFIEIYCSRNTSPEAIKQGLARYPEIAAASTVTGEADAVVQVFAADMRHFEQVLERIAGEPYVERTKSVLVLSPLLRRYSAEAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFS7</accession>
    <name>A0A7K2ZFS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FkbM family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000865">
        <property type="protein sequence ID" value="MYW31211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029476716" evidence="1">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_21" evidence="2">
        <location>
            <begin position="57"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="28081" checksum="8D559B72F90DEDDE" modified="2021-04-07" version="1">MTTFAAAVASRLPTGLVASAAVALYPRFEPELRRLADFCPPGSTAVDIGGWYGPWSRRLARRCDQVVTVEPVPHLAAHLRRTLPSNVRVVQGAATDRDGSTVRLWLPEGDDGDRGVSSLERRDIHAHCVEVESLTIDGLSLRGVGFVKMDVDGAEVAALRGAAELLRRDRPALLVELESRLGPIAPAVTLLTGQGYAGWVLAGRRWVPLSGFDLPAHQARTEHLVHQGLLRRAFVPRRTRYINSVLFLPEGRVPGATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFU2</accession>
    <name>A0A7K2ZFU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_18220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000860">
        <property type="protein sequence ID" value="MYW31155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9341" checksum="7B6704E6B3BA8407" modified="2021-04-07" version="1">MTASHLLVPVPIPDRVAALIGSCIPPHILEAEFDADCAAREVRRFRGPRLGIEDQADREQALAELARANKVLAAHHPRLAVGPGSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG72</accession>
    <name>A0A7K2ZG72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="17057" checksum="7EC5BEECE92E84C6" modified="2021-04-07" version="1">MASLNVGNLGEYLREQRNAAQLSLRQLADAAGVSNPYLSQIERGLRKPSAEVLQQVAKALRISAETLYVRAGILDEREREELETRAVILADPSINERQKNVLLQIYDSFRRENGFVPETDKADQTPEADATPGADATPGADDALKADAAKDDNPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGA4</accession>
    <name>A0A7K2ZGA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000907">
        <property type="protein sequence ID" value="MYW31362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="236" mass="24486" checksum="A099F3B472C5C64D" modified="2021-04-07" version="1">MAITDDLRKTLTDRTPLYFAAGTADLAVQQALKVPALIEQLRAEAPERFEAVRNTDPKVVQEKVTTQAKEAQATVQAKVTEVFGTLDAADLRKLGESAQDLALRGVGIAAEYAVRARETYEKVAVHGEQAVRTWRGETADEIVEIAAVVEAAPKTAPAPAPAAKSEPKATAATTRSAPKPTAVKPEAAAKPATPAAKPAAPAAKSAAPAEAKAAPAKKAPAPRKPAARKNTPPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGH8</accession>
    <name>A0A7K2ZGH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000918">
        <property type="protein sequence ID" value="MYW31436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="375" mass="39373" checksum="61D441E9ED093032" modified="2021-04-07" version="1" fragment="single">MLKRVFVAPDPGRVRLRFASRAVIGIGLAVALCGLVGHSLVAAITGGLAALLALFTVTDATVRQQAVTTALLPVAGLPVLAVAAVLHDQPVARDLVFLAVMGAGVYARRWGPRGHSLGVFAFMTFFAAQFLHTVLGQLPELYAAVLLSLAVSSTVRFGFWCYERRLPAVAVPAPPEGRGLARITTRQAVQATLGGAFALGLGQVLSDQRWYWAVGATWWVFVNTTSRGETLVRGFRRVLGTVIGIAAGFLVAIPLEGAGAPTAAIVAVCVFGIFYTAAVSYSWMMFFVTVMVGVLYGVLGVLDASLLWLRVAETAVGALGAVLAVLVVLPVTTHAVTDAWIRKALRCVHGCTAEAAERLAGSLSADPGPRVAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGN3</accession>
    <name>A0A7K2ZGN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">murB</name>
        <name evidence="19" type="ORF">GT040_20025</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="WWKE01000933">
        <property type="protein sequence ID" value="MYW31500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MYW31500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="351" mass="36667" checksum="A6E81EAC47BAAD77" modified="2021-04-07" version="1">MQELHDAPLAPLTTFRLGGPATRLLTATTDAEVVAAVAEADASGTPLLVIGGGSNLVIGDKGFDGTALRIATKEFTLSGTSLELAAGEVWTDAVARTVDAGLAGIECLAGIPGSAGATPIQNVGAYGQEVSSTITEVVAYDRHTRETVTLPNAECSFSYRHSRFKAEPDRFVVLRVRFALEEAGGLSAPLAYPETARAMGVQQGERVAASAARETVLKLRAGKGMVLDPDDHDTWSAGSFFTNPILDEAAFQDFLARVHERLGPDVTPPAFPAEDGRTKTSAAWLIDRAGFTKGYGSGPARISTKHTLALTNRGEATTEDLLALAREVVAGVHAAFGVTLVNEPVTVGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGY1</accession>
    <name>A0A7K2ZGY1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="4 11">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrB</name>
        <name evidence="14" type="ORF">GT040_20580</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 11"/>
    <dbReference type="EMBL" id="WWKE01000971">
        <property type="protein sequence ID" value="MYW31607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="204"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW31607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="305" mass="31308" checksum="268C935687217E80" modified="2021-04-07" version="1">MAGPAFRAAAVRVRVPATSANLGPGFDALGLSLGLYDDVVVRVADSGLHIDIAGEGGETLPRDESHLLVRSMRTAFDLLGGQPRGLEIVCANRIPHGRGLGSSSAAICAGIVAARAVTTGGDARLDDNALLELATEIEGHPDNVAACLLGGFTLAWMDGGAARAIRMDPAESVVPVVFVPGRPVLTETARGLLPRTVPHVDAALNAGRAALLVEALTRRPELLLAATEDRIHQEYRGPAMPESVELVHRLRADGVPAVISGAGPTVLALAEEGSADKVARLAGEGWAANRLALDAAGATVLPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH64</accession>
    <name>A0A7K2ZH64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000986">
        <property type="protein sequence ID" value="MYW31690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14557" checksum="69F599D965F18891" modified="2021-04-07" version="1">MSQHGFDLPPKATRDVMNRRRELAEKACDALLQAGLPAFLEASQGVPGAQIQVESLADGGVLVEWSTQESLAAAAVDILENGVDPTNLPQPIRHYETVQACMRDAVLRILASAGFHVERADAHTYGSAVHVKGDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHD0</accession>
    <name>A0A7K2ZHD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="459" mass="48898" checksum="E55BA3AD4398E390" modified="2021-04-07" version="1">MTSPSEELLPSTRRSLLHRLATAQREGRAPSLAAAVRREGRIVWSGGRMGLEGQVPDADTQYRIGSITKTFTAVLVLRLRDEGLIDLDDQLEKHLPGTGAGGATVFQLLGHSAGLGAEAPAPWWERTPGTLRPELGDVLGERPQMHPAGHRFHYSNPGYALLGSLIEAVRGVSWEEALRREILEPLGMHRTTGEPVAPYAEGWAVHPWADVVVREPAEDLGLMAPAGQLWSTAADLLRFAAFLAEGDDRVLSAASVREMRMPAAPAAESGGNAYGLGLQVVKTDSRVLFGHAGSLPGFVAGLWFSEDDDVAAVALANATSGLPAATVAAELLSIVADAEPRIPEPWRPLPEADEELLALAGIWHWGTHTFTLRLTGGRGLELRPLGGTGRGAAFTPRPDGTWTGQDDYYAGETLRVVRRADGSVDHLDLGSFAFTREPYEAGADVPGGLDPAGWRGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHS1</accession>
    <name>A0A7K2ZHS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001019">
        <property type="protein sequence ID" value="MYW31809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026242095.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001019.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9689" checksum="EA5DD9873910F829" modified="2021-04-07" version="1">MEQITVRSRPRVPAITCGSGATSTRLDRHLAVLGGPVVPQRESAEATLLMRELTSRDAAHTRRSRSARVSLFAPLRRLRRSLFGSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI09</accession>
    <name>A0A7K2ZI09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination factor Rho</fullName>
            <ecNumber evidence="6">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rho</name>
        <name evidence="9" type="ORF">GT040_22620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01001064">
        <property type="protein sequence ID" value="MYW31990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="8">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="379" mass="40747" checksum="BF64A60FFC6EDFB8" modified="2021-04-07" version="1">MTTTLERPAIREPRPVRAAGLLDTVAGGHGLLRVQGGHPSPDDIKVSPALIRRYGLRKGDAVEGSCERPRVLATVDRVNGLAPNLLAGRAHFRDLTPVHPTERLRLETEKGGPAPRIVDLVSPVGKGQRGLLVAPPKTGKTVLLQQFAAAVATNHPECHLMVVLLDERPEEVTDMRRSVRGEVYASTFDRPAKEHIALADLAVERAKRLVEQGQHVVLLLDSLTRLCRAHNNAAGPGGRTLSGGVDAAALAGPKKLFGAARCAEEGGSLTILATALVETGSRADEFFFEELKGTGNMELRLDRSLADRRVFPAVDIARSGTRREELLTGPAELATVRALRRALHARDGQGALEALLDKVRRTPDNATFLRQVQPTVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIZ4</accession>
    <name>A0A7K2ZIZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1345 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001148">
        <property type="protein sequence ID" value="MYW32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009781">
        <property type="entry name" value="DUF1345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07077">
        <property type="entry name" value="DUF1345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="22658" checksum="D74120A4124719CD" modified="2021-04-07" version="1">MSPLPHRPALSAVPRLVVAAVLGVVAGVVTGLLTHAPLGVLAGIAAAETIFVVAGWIALWPMDAATTHHNVRREEFRPVLEELVVVAAAVCGLVGIVVLLLTSDSDLSHAAAAIALGGVFTAWASLHLMYATRYAYLYYLPTEGGIDFNSPDSPKYVDFLYFSYNLGMTYQVSDTNVSATEIRAVTLRHCLLSYVFGASILATTINLVTGIVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIZ8</accession>
    <name>A0A7K2ZIZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_24390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001148">
        <property type="protein sequence ID" value="MYW32321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="38"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="352"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="385"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="591" mass="61268" checksum="ECCD73798E37DD11" modified="2021-04-07" version="1">MTSDQTTPPVTTLPVADARRTREEILRRLRAQRRRLGAALLTLLGGTAAALATPPLLGGIVDAVAEGSGQGQVTALGLALVATTGVGAVLAYAGGRMLVALVQEVLAGLREDVFETAVHLPVNTLESTGSSDVVSRVTRDVEAVSEAASDVLPEVTHASFTIGLSLVGLAVLDLRLALAGLVCLPVHVYATRQFLRRSHRVYGDIRRLESARGQVVIEAVRGAESIVAYRTQAHHLDDLAERSVHAIERQRDGVKLRNRFTGLLNAAEFLGLAAVLVTGFALFGSGAVTLGAATAAALYFHRLFGPVGALLGSLDDIQRATVGLSRLVGITDLGGHPVRPAGEAWGSGRPDIDVKGVSYAYDGTRPALREVSLHVPAGTSLALVGASGSGKSTLARLVAGLGTPDRGSVTVGSPDAPASRYLVTQEVHLFGGTLADNLRLARPDATDDRLRHALREAGADWALNLEDGLDTVLGPGGTPLDDGSVQHLALARVLLADPPVVVLDEATAESGPRTRALLQGALARVTAGRTSVVVAHRLEQASLADRVLVLRDGEVAELGTHDELLAAGGAYAALWAAYHRSGPGGGAPVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJK3</accession>
    <name>A0A7K2ZJK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001171">
        <property type="protein sequence ID" value="MYW32439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="571" mass="59708" checksum="019B87BB6D174DBC" modified="2021-04-07" version="1" fragment="single">FRGAGGLTQRVPTEHLIPAGTEPLPSSAAGEQERPVDAGLARRVALADSLAPLGVSDTAGQHQGGGGLFDAVASVLHPSVTAPGAPGRSRLYEATATPTVLEDLPRLLGGDGVTGDDLHSKDGSSAGSYRMRAVVTGLTPAWANGKTQLRTHQQAQHTATDSAGKGRSVAGGIGPAIGVGAAANAAVVRATAMPVAAARKARFSVNEQTVSSRQGAEVRGEKVLYRGTVQFTVEGTGPRSVQAILRPEARVATHALRVWVSLRADEAQELGLPLPPGVEAGEFIKQPEAGADARHLPFGATGSSVTLGRLDTAPMMKAVRELFATDPRLAGYLPAFGATRPPADLSREEEEAQRANDRELMAALSEANLRVNKDQLLSTGIRVRLRRKTAMHAHDVQLRVHGTMGEAHHLGDMDDWLVRAHAGVAANAQTGRSSSRSIGGMLLAQARLIPGVLTGSARYERQSSGTRRNQAGPTTRTDVLTNGSEKASAFGAALRLNVDVTMTSRQRKPARAVTPGAPGRDVPEAKLLSGLHLEEQDVRLLTPSEFTVGTDERARLDAGAGQAPGPERPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJK5</accession>
    <name>A0A7K2ZJK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_25395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001196">
        <property type="protein sequence ID" value="MYW32514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="546" mass="55473" checksum="5C46A2CF05CA8D2E" modified="2021-04-07" version="1">MEGTVVREPSATRRWLGLIAIALGVALIVVDTTIVNVIVPSVIEDLDATSIQAQWIQESYAIVFAALLLLTGRLADIFGARRIFLSGVVVFGATSVLAGLAPDSGLLILARFLQGAGAAMLLPTSLSLLKATFTGKARGQAFAVWGSTIGAAAALGPLLGGWLAEHVSWRWAFGINVPLSVLVGAGVLLYMAPSPRTRGRIDVPGALLSVAALGLLAFGLVEGRTYGWITTVHPLEVLGLTWSGGPSPVLVALVLSAVSLFAFVQRQIVLGRAGDPDRVLMDVSLFSIASFRSGNIATLIIGIGEFGVVAILPLWLQFTLGYSALQAGLALVPVAIGSFVASGASFGMAAKVAPLGQLRVGLALEVVGLAGIGLIAAPDSSWWSVSLVLFLYGIGVGFATAQVTNVVLNDVPEVSSGQASGVQSAFRQLGSALGIAALTTVFFTTLSTRLNDRLTGGGLPAGEADRLTGAVTDSAGAAIGPLAANPQTASVADAARAAMTDGVVLGGYVAAGFVLLGLIASFLIPSAPAADGDASGPAREAEPALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKE9</accession>
    <name>A0A7K2ZKE9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">recF</name>
        <name evidence="10" type="ORF">GT040_26950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001255">
        <property type="protein sequence ID" value="MYW32813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="376" mass="40925" checksum="168E43ADEB4878D0" modified="2021-04-07" version="1">MHVTHLSLADFRSYARVEVPLDPGVTAFVGPNGQGKTNLVEAVGYLATLGSHRVSSDAPLVRMGAERAVIRAAVTQGERSQLIELELNPGRANRARINRSSQVRPRDVLGIVRTVLFAPEDLALVKGDPGERRRFLDELITARSPRMAGVRSDYERVLKQRNTLLKSAAMARRHGGRSMDLSTLDVWDQHLGRVGAELLAQRLDLIATLQPLADKAYGDVAPGGGPVTLEYRSSVGEDIDPASTRDELYERLIAALVGVRKQEIERGVTLVGPHRDDLLLGLRSMPAKGYASHGESWSYALALRLASYELLRTEGNEPVLVLDDVFAELDARRRERLAELVAPGEQVLVTAAVAEDVPGVLAGARYAVSAGEVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKQ2</accession>
    <name>A0A7K2ZKQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001295">
        <property type="protein sequence ID" value="MYW32922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="146"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="386" mass="41037" checksum="0B2E784FFEFCC433" modified="2021-04-07" version="1">MTPEASASGAPLRVALVGYGLAGSVFHAPLIAATEGLVLDTVVTSNEERRAEARAAYPDLRFAASPDELWERADELDLVVIASPNKTHVALATAALKSGLPVVVDKPIAGTAVEARELAALAEERGLLLSVFQNRRWDNDFRTLAALIADGELGEVQRFESRFERWRPQPKGGWRESGDPEEIGGLLYDLGSHVVDQALVLFGPAVQVYAESDVRRPGAAADDDTFIAITHANGVRSHLYVSATTAQLGPRFRVLGSTAGYVKYGLDPQEAALREGKRPGTAGEPWGEEVEEVWGRLGSGESPLTGGGTPVRTLPGDYPAYYTAVAAAVRGAGENPVTALQAAAALDVLEAARRSAREDVSITLIPHHDEAPHDEAPHASGKEHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKS4</accession>
    <name>A0A7K2ZKS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_27615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001297">
        <property type="protein sequence ID" value="MYW32940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="586" mass="63447" checksum="50C9D0CBE5A366D5" modified="2021-04-07" version="1">MSTAQHRNGAVRETPDRYGAFPRLTTEQLHNLTAHGERRRTTEGEVLYREGEPFREFLAILSGTVEILQDHSDREERTMALHGPGRFLGELGMLEGQAAFDTAVVREAGEILAVPVERQRTLIGRDPVLGDLILRACLGRRYLLIGLGAGFRILGSCYSQDTRRLREFAARNRLPHRWLDLERDKEAEALLRRFSIRPEETPVVLWKGDRVLRNPSNAELARLIGLPAPTAKDAQCDVVVVGAGPAGLAAAVYGASDGLTTISVDAVATGGQAGTSSRIENYLGFPSGISGGELIERAVLQAHKFGARLMVPAQVNRLTPQDDAYVVTFTDGSHVRAGAVVLASGVRYRRLEVPGIERLEGISVYYAATVHEASLCEADPVAVVGGGNSAGQAALFLAQHASGVHLLVRGGDLNADMSRYLVDQVERHPKIEVLLHTEVRGVSGKDKLESLSVEDNTRGERRPLRAAALFVFIGARPRTEWLRGALALDEKGFVLTGADARAAADATRWDALGRAPLLLETSLPGVFAAGDVRSGSVKRVASATGEGAMAIRLVHEHRENAGNLVRDRTTGRERPQPDADRSASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL80</accession>
    <name>A0A7K2ZL80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001316">
        <property type="protein sequence ID" value="MYW33100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012381448.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="6210102"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="63" mass="6590" checksum="57E5125EE6DC2919" modified="2021-04-07" version="1">MSMAVAGLLAGMALGFAGYFGGFGAFVLVAALGAVGFIAGRFLDGDLEPGDFFRSRERGDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLH1</accession>
    <name>A0A7K2ZLH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VCBS repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001350">
        <property type="protein sequence ID" value="MYW33186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029772870" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1015" mass="107270" checksum="53B6BD6223123114" modified="2021-04-07" version="1">MAALAALLTLGVPHHLPEAAAAESTTAPKPVASKADAEALAQTEAARSGRPVEVLAQRTEVSRVFANPDGTFTQDTYALPQFVRQEHTLVPIDTTLEVNGDGSLSPKAAEVDVRLSGGGEGPLVTLVRDGRSMSWSWPRPLPEPEVDGDTLTFGDVLTDVDLKIKAGPAGFSSLLVVKTPEAAADPALKQVSFGLDTSGLAVSTDAHGNFTAVNPAGEEVFTAPTPLMWDSSTAAAPAAPAARSARSAPSGPPPPSDEFEPGHGARQAAMGIAVTGGKLRLTPDRELLTGKDTTYPVLLDPAVSGSRHSWTIAHKKHPNSSFFNGANWDNGTTTARVGYENETDGLSRSFFRMNAANLWSTNKVVSSSTFRIKNTWSWSCTNRTVEMWETGAISASTTWNKQPDWRKKLDSVNESLGWGSACPGGNLAFDVTAGAKDVIANKWKTLTLGLRATKADEDNRNVLSWKKFDAKSAVLSTTYNTVPNAPNSLDTIPSSGGCDMVAPYTTIGNTDVTLTAKVSDPDGGTVRAQFRLWGTDNLAGGAEIFNQIVSATSGTVAKAKVPKATLQKYLAAAKGNFGWKVQTLDAGANSAWAPNPGTCRFDFDPTRPSTPPTISSQQFPDGSDGWPAVTGQARTAGTFILGNGGVNDVKSYEYWSDWDPTVRNVTPSTDLDGDGKIDAKLVLTPPSAGSQRLYVRSLDAAQNRSDRASYLFYADGLSIPDKAGDLNGDDNADLYGVRGNGELWLYAGQGNGYVGTGTVASNGDFTGAGITHRGDWTGDGFEDLVAAIPGDEGKSLHLYPNNGAGWACIARDEQADGYSRSCQYDRQEIDVYDGANNHWKNADQILAIGDVDGPLDTDGDGTIDVAGYPDLLVKEGNMLWLYFGSESLYLDESRDPVLLGNGSWSNYDLAAPGDRTGNGRVDLIARHKTSGELRLYEGTGASGEGLGNGAASTVIGNGWTRTYRPLLTAFPDAGSDKKADIFATGGDDKLYLYSNLSGSGVAVGSSGWLDFRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLL9</accession>
    <name>A0A7K2ZLL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001355">
        <property type="protein sequence ID" value="MYW33230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="19266" checksum="32283D85BCCD598D" modified="2021-04-07" version="1">MPGKDTRSAFDRYAGTIEAAPVAVGQILYRSVLRNSDKGKKSASYQADLTTWIRQAQRGESDPEEASDIFSLSAAHWAFLAALGIMSGMLLDHLFGVSFDAVLTCSLSVFPAFALLSVADAVRARSARETGAARKRPGKRKQESRRYRPIRHRWIIPVAAAVLLAAFWLLLLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLX2</accession>
    <name>A0A7K2ZLX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_29860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="27596" checksum="D48DEECE82B17227" modified="2021-04-07" version="1">MPVAAAWSGGGGLDDRVPFLARLESEDRAALLDLGRELSFPARSTLVHQHEPSSHVLLILHGWTKVTASAENGYEALLALRGPGDIVGESAALTGRPRSATVTALAPVLASVIERGSFREFVAHSPAVSLELLGLTSDRTRAADQRRLEFASMSVRERFAVLLLDLLHTHGHRTEAGIEIDVPLSKQELAGAVGASREMVQRLLKDLRARGIVITGRRTLVIVRPGILRRIAGSTFPDPCDPRVGPAAPPSPWGTSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM77</accession>
    <name>A0A7K2ZM77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_30130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001391">
        <property type="protein sequence ID" value="MYW33410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="338" mass="36056" checksum="E0A6A65E8560B18D" modified="2021-04-07" version="1">MASIKDVAAQAGVSVATVSRVLNSHPSVSEEARARVLAAVDALGYRPNAVARSLRTAQTRTLGLVISDVLNPYFTELARFVEEEARALGYSVIIGNADERPDLQDHHIRTLIDRRIDGLLVSPADGGSPLMREVALSGTPMVFVDRWIPGIEVPVVRADGTGAVKDLVAHLHGLGHRRLAIIAGPAATTTGNERVEAFRDAMRELGLALPDAYIGQGDFQAASGRRATEGFLALDEPPEVVFAADNLMALGALDAIRARGLRVPDDIALAAFDDIPWFVHTAPPITAIAQPTADLARAAVRALADLIEGRTPQSLTLPARLVVRRSCGQDATDQRSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM90</accession>
    <name>A0A7K2ZM90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001396">
        <property type="protein sequence ID" value="MYW33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="21469" checksum="75CB8FBCA520F013" modified="2021-04-07" version="1">MSEPTPSPGDAYKWGPPQQQPGHPQHPGHPPTVADGQAYGYPPPGGAPAYGYPQPLPESATQPGPGYGYPYPGQPTMPGQYLPVPQGVPGQGGVPVLSIGDITVMSDAIVTPSGTMPLKGAVWTATDMSRTEEKIPAHAIVLAIVFALFCLIGLLFLLMKEKRTVGFVQVTVTSGGRHHGTMIPATGPHTFPAVMGQVNQARSMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMG0</accession>
    <name>A0A7K2ZMG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_30715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001415">
        <property type="protein sequence ID" value="MYW33522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="30770" checksum="A6083BD73D3DC467" modified="2021-04-07" version="1">ADGRSGAPADDPAARPAPQGGHPAVEFRDVSFGYGDRPVLEGVSFTVPAHGLTAVVGASGAGKTTVFQLIERFYRPGGGAILLAGRDIAHLPTAEIRGRVGYVQQDNAAMRGTLRENIVYAAPDATEAEIAEAVELAGLTEVVAELPDGLETLLGDQGTGLSGGQRQRLCVARALLQKPDVMLLDEATAHLDSDAEAALRDSLRGIAGRCAVVAIAHRISTVAEADRIVVLDEGRVRAVGTHTELLGNDALYRRLAATQFADGPLGGRPVTDPVPDGAQGAVPVPEPVPAALPGAGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMS8</accession>
    <name>A0A7K2ZMS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="27811" checksum="630BA9F2B24A0E5F" modified="2021-04-07" version="1">MVDPAQRVPRYVEIADELRSRIDGGAFDADGKLPSEREMGEEFGVARGTIRDALQVLRAEDRIESRRGAGNFLRSFERVNRDVVARLSRSQWGAGRSIWDRDTGPRHQESVDIEKVSPPKRIAGVLGVYGQEVWRRQRVHQVAKRTVQQSTSWYPADLAEGTAITEPNTGPGGVYARLDEIGHGPARYREEVMVRLPLPEEVATLGITLTTPVILVARTAFDDDDRPVEVNEMVLDADSFRLIYTFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMT9</accession>
    <name>A0A7K2ZMT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001438">
        <property type="protein sequence ID" value="MYW33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="412" mass="44393" checksum="B3CDD2F8F93827AB" modified="2021-04-07" version="1">MTTLRTDHRTAGGSGRGPRRKALVIGAGIGGLTAAVALRAAGLDVEVYERAGELRAAGSGLSVMSNAIAALDSLGLGIDLAKRGSVLESYHVRTARGRLIREFPFPEIIGRLGTPSVLITRSDLQQALLDAASGIPITLGAQAVAFESEADGGVRVRFADGTEARGDVLIGADGFNSVVRRQLTGPEESMDSGYICWLAVVPFSHPHFAPGSVTHYWGSGSRFGLVDMGGGRLYWWGTKNMPTEESHDWKGGKADVQRAYAGWADVVQEAVRVTPEEDILAVPSRDRVFLERWGEGPVTLLGDAAHPMLTSLGQGSCMAIEDAVVLGRRLAGATDLPAALRRYEDDRRERTRALVAASRAISTFEQSENPVRRPVRDAYFKFLPKRRLVRTLESALTYPAVTPGRPEPKERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN55</accession>
    <name>A0A7K2ZN55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine racemase</fullName>
            <ecNumber evidence="4">5.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">alr</name>
        <name evidence="4" type="ORF">GT040_32095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001468">
        <property type="protein sequence ID" value="MYW33786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006522">
        <property type="term" value="P:alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="3">
        <location>
            <begin position="96"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="24581" checksum="4F4B52A52F4665C7" modified="2021-04-07" version="1">AERTGAIRITGLWSHFACADEPGHPANAAQLAAFRDMIAYAEKEGVEPEVRHLANSPATLTLPEAHFDLVRTGIAMYGVSPAPELGTPAELGLRPVMTLAAAVALVKDVPAGHGVSYGHHYATPAETTLGLIPVGYADGIPRHASGRGPVLVGGTVRTVAGRVAMDQFVVDLEGDRPEAGAEVVLFGPGDRGEPGVEDWAVAAGTIGYEIVTRIGSRVPRVYVNETAGPADPSGGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNH2</accession>
    <name>A0A7K2ZNH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_32215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001482">
        <property type="protein sequence ID" value="MYW33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_032771996.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001482.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="31464" checksum="C7374AA621AC8AAE" modified="2021-04-07" version="1">MVSPLALAGRRGKVTYWSVFALVVVLFAFAFLFPVYWMVTGAMKPPEEVVRTPPTLVPEQWQVTGYTDAWDLMRLPTHLWNTVVQATGAWVLQIVFCTAAAYALSKLKPAFGKVILGGILATLMVPVQALVVPKYLTIADMPLIHVNLLNDPLAIWLPAVANAFNLYLLKRFFDQIPRDVLEAAEIDGAGKLRTLWSIVLPLSRPVLGVVSIFALVAVWQDFLWPLMVFSDTEKQPISVALVQLSQNVPLTVLIGAMVIASIPMVLMFLVFQRHIIAGISAGSTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNI3</accession>
    <name>A0A7K2ZNI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_32680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001492">
        <property type="protein sequence ID" value="MYW33897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043763">
        <property type="entry name" value="DUF5709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18970">
        <property type="entry name" value="DUF5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5709" evidence="2">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="19272" checksum="18C0387A0BE5485C" modified="2021-04-07" version="1">MSDTDWGDDVYQPQEQEAADPDEQLGSEDTLLDPSGTGDPLDEGYSPPDRPWVVEGLGTTAAESLTGESLETRLTREVPETPGFTGDGVGDLAGGDGELWDGKVGVARAGRLTQTADGTVPATLTASDVGIDGAAASAEEAAMHVIPEEGDDESLLDGSLPDGALVDGAAEAGAPVDSSSVEGSVEGSAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNK2</accession>
    <name>A0A7K2ZNK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="37486" checksum="C00F34D17CA6B4F8" modified="2021-04-07" version="1">MDAQGEEITVDQAAEDFAAEVARWREVRGMSKRALARAMGFDPSYVSHVESGRHKPSEDFARLADEALKAGKSIWRRWRTYEKARVRTSLTPSTPSAPHRPEQPYATDSALVVQHDAASLQYDGRSYRLIMRRLLRNTGTEPVTRYLIRISVDRYPGDPEQSNAHYRAHPLTWDELDLTATCRGEKMRWQAKHDRDAFKEVWLLFDNEHGRFPLYPGESVWIEYAYTVGHEKWGNWFQRAVRLPTEQLEVQLVFPAALDPVVWGTETSMTAEASPLRTPPIRGDAGEQRTFTWITTTPALHARYRLEWRFRAQPEPDSDQGEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNR5</accession>
    <name>A0A7K2ZNR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_33165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001511">
        <property type="protein sequence ID" value="MYW33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="154" mass="16259" checksum="A04AA365352F3CBC" modified="2021-04-07" version="1">RVAVETGRVQAWTTLAQAAGAGLECVSLYDVGRVPPTGATVGSPVVVIRDCGMRPPRGRVISSPWQSVLTLLPYLSPVAPRLLRSSALVGIQRVSPDEARQIGRILGLAPAESEALPTLADGVTLWVAGRDHHWVMTSATDAETGLLGSARRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNV3</accession>
    <name>A0A7K2ZNV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_33435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001539">
        <property type="protein sequence ID" value="MYW34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="193"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="34910" checksum="2549A279EBE5B581" modified="2021-04-07" version="1">MSNLDRQATPSVCGGRGFVVAEPVRELLTPRRVPLGESTEVRRLLPNLGRRMVGAWAFVDHYGPDDIADEPGMQVPPHPHMGLQTVSWLHDGEVLHRDSLGSLQTVRPRELGLMTSGRAISHSEESPKPHARFLHGAQLWVALPDAHRHVEPHFQHHTDLPTVTAPGLTATVILGELDDAASPGTAYTPIVGADLTLAEGAEARLPLDPDFEYAVLSMSGEAEVDGVPVLPGSMLYLGCGRTELPLRALSDAGLMLLGGEPFEEEIVMFWNWIGRSQEDIAQARDDWMNGTRFGEVKGYDGPPLPAPELPAVPLKARGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPQ3</accession>
    <name>A0A7K2ZPQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GlsB/YeaQ/YmgE family stress response membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_34835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001591">
        <property type="protein sequence ID" value="MYW34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="91" mass="9782" checksum="3A48EEB8D9ED6AAD" modified="2021-04-07" version="1">MGWLWAIIVGLVLGVIARAILPGKQDIPIWLTIIFGILGSILGNAVAGWIGVEDTKGIDWIRHLLQLAGAVAVVAVGDMAWQSIRGNKRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQP1</accession>
    <name>A0A7K2ZQP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001679">
        <property type="protein sequence ID" value="MYW34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="100" mass="11003" checksum="245FB392893C0A7F" modified="2021-04-07" version="1">MFVLELTYTAPVERADALMKEHIAWLDEQYAAGVFIASGRKNPRDGGVILAVGEDRQRIEEIAAADPFAAHGVCAYRITEFIATRTAPELAPFKQELPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQT6</accession>
    <name>A0A7K2ZQT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molydop_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_36420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001654">
        <property type="protein sequence ID" value="MYW34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molydop_binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="59" mass="6475" checksum="05ADED6C02948014" modified="2021-04-07" version="1">RGRAVAPARITGAIRADTVFMPFHWPGEGRANTLTNPALDPVSRMPEFKVCAVRLEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR80</accession>
    <name>A0A7K2ZR80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
            <shortName evidence="3">GlcNAc-Ins deacetylase</shortName>
            <ecNumber evidence="3">3.5.1.103</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">mshB</name>
        <name evidence="5" type="ORF">GT040_37755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate</text>
            <dbReference type="Rhea" id="RHEA:26180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:52442"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="EC" id="3.5.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MshB deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.103" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001707">
        <property type="protein sequence ID" value="MYW34874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035595">
        <property type="term" value="F:N-acetylglucosaminylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01696">
        <property type="entry name" value="MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017810">
        <property type="entry name" value="Mycothiol_biosynthesis_MshB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03445">
        <property type="entry name" value="mycothiol_MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="31438" checksum="BD261344B0131BAD" modified="2021-04-07" version="1">MKDLPARRLLLVHAHPDDESINNGATMARYAAEGAHVTLVTCTLGEEGEVIPPALAHLAADRDDVLGPHRVGELAAAMKELGVTDHRFLGGAGRFRDSGMMGTEQNERPGAFWATPVDEAAAPLVEVIREVRPQVLVTYDPDGGYGHPDHIQAHRVAMRAADLAADPAYGTGAPHTIAKIYWNRVERTVLEAAFDHLRTTAPDTFPGIAAVDDVPGVVDGDEITAEIDGSAYAGAKAAAMRAHGTQIAVDGEDAFFALSNDLGQPLLTAECYQLVRGVPGSGGGAREDDLFAGLPEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR94</accession>
    <name>A0A7K2ZR94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF262 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001686">
        <property type="protein sequence ID" value="MYW34769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="602" mass="67566" checksum="FB723E957A4FAF78" modified="2021-04-07" version="1">MTTAQGGELTVRGESVQRLYAFYINDRFRVNRRYQRKLVWSVEEKQRLIDSLLKDLPIPLFLVAEIGQPGDVSFELIDGMQRLNAIFAFLENEFSIGGEYFDLDSLADTKLRKDKKEISQKTPVISRELSVQLANYTVALSVYRPASSASVDEVFRRINSGGRRLSRQGLRQAGTLSPLADLVRVISSEVRGDTSPSDVVALRTMPKLSITNRNLDYGVQVDDIFWVREGVLRREDVRESTDEQLVLDILIDCFIDPIPNSGTRLRDEYYNYTDIDPEEGETKASRLVNSAIEAYGAERIKNHFMRTYDALRSVLAQQEKKFSGLINTSSGGRSPRYFHAVFMAFYELMFKEGSYLVNPKLASERLQGVGSSVMAVPGGGGDWRRDSKRQTINAVKGVMGDAFEEGSSSSQDLGRYGWASQLERLLGNALVEQQTFDCKQGFLRLDSSRKFDSESFGKICRTITAIANMGSGVTGYVAIGIADNERAARRVEMLDATETVMCRDFHVVGIERESALLGKSLNDYWTWICQLLQTNGLDADLARRVSAESKLVQYQGRIVALLKVSAGSTPYFHKGEMVERSGSETLTVATSDYLRVYQRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRB7</accession>
    <name>A0A7K2ZRB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001697">
        <property type="protein sequence ID" value="MYW34838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14438" checksum="F9DDD05DAC167573" modified="2021-04-07" version="1">MLIQAHLGYAQLHRLELSKADYDLLSAMTEVQRPGGEVNASQAELRARVGLSKNRTSIAMSHLVERNVVLRPEGRYRSYFIHPYFAGYASQEEMEDALREATEAIKAGALAAPAPPAPQRHLSAVPARRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRY8</accession>
    <name>A0A7K2ZRY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_39080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001776">
        <property type="protein sequence ID" value="MYW35126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029757916" evidence="4">
        <location>
            <begin position="32"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="35"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="175"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="682" mass="73106" checksum="87787F66CA9C33D7" modified="2021-04-07" version="1">MMTRTRLSALAATAALATIGGLVTAAAPAAAAVTCASPVWKAQYFGNSTFSGTPKLTACDTAISESYGKGAPAGVTLPKDNFSVRWSLTRDFGSGGPFRLSAATQDGMRVYVDGARKINLWKNVSATVRKTVDLTIPAGKHTIRVDFVAWTGVANAAFTYTPRTEAAVDTVKPLAPTGLTAAYDRTTARTTLRWAANKEMDLAGYRVYRRLSTTGWAKISGTSALTTRSFADAPPATGQTFLYEVRAVDKAGRESTGSPDVTATTVDRTGPATPTGLVVTTGDGWYDTLSWQKAADAAKYEVYASPTPTGPFALRGTTTTTSYRTDGAVNKNTYYRVRALDAVGNPGAYAAVTSDGVDRMPPKSPTDLDVVARVGHTDLHWRQPGSFMEDYDNGGYYRVYRSPGKTFDPAARTRVTCVAEESDDAGNGGNCYDVDMPANTYVTYAVTAVDPYGNESAYSAPLVVRTGDTVAPDPVTGVKVTARNDGMLVSWAASPEDDIDEYVVWKGARQADGTVKWLGPDTCSQSTGNWLAILCGNLPDGQTHVYAVMAKDHWGNTLHPSDPKVTVVEATERDVRPSVTVTQDWSLGRPGHNRTATRPSVDWQCTDTARCATVTGFRVGRWNPTAKAYEPQHDGLLPAGARTWEDTTATKGDTYFYTLEAVTADGTVVGTYPWHIVFQDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS72</accession>
    <name>A0A7K2ZS72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001778">
        <property type="protein sequence ID" value="MYW35138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="291" mass="30885" checksum="5938E383F01F7940" modified="2021-04-07" version="1">DAEGPALVVTSDPTVWAETKDARAKLGPVLVYDPGHLCDTPARLHWPPTAGCEDPDTAGVRAAALLAPVRPQARIDAAVADTAQTLLQCWLHAAAVDGRPFRQVARWASGASAHEPVRLLRTHPKAASGLAGLLESALTGYPERRDVAQELNVRAFSALSSVHIRETCTANRSDAAALDSFAREGGTLYVVGEPIEDPRTRPGAMPLLTALASHVVEHGRRMAARSSDGRLDPPMTLVLDDVAAVAPLPQLPELLARGQDLGLPAIALLRSREQGRARWQQHLHAPAPGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS95</accession>
    <name>A0A7K2ZS95_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetyl-CoA carboxytransferase</fullName>
            <ecNumber evidence="3">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_39775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001824">
        <property type="protein sequence ID" value="MYW35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW35251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="79" mass="8386" checksum="864D76F938AD03A9" modified="2021-04-07" version="1" fragment="single">PASGREAVERARSPQRPRAEAYLADYFTVRLPLHGDRCGGTDPGLLTGFGLRADGQPVAYVAQCGTPTRPAGYRAAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSA6</accession>
    <name>A0A7K2ZSA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="48" mass="5660" checksum="A7FB6967B2AC94DE" modified="2021-04-07" version="1">MNFTVYTIEMAYARMRELQDLANRSRAHQPAAAHRVDKTRAPRTTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSJ2</accession>
    <name>A0A7K2ZSJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001788">
        <property type="protein sequence ID" value="MYW35189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="31532" checksum="BECE3AD54D687EF3" modified="2021-04-07" version="1">MLHGPVVRRRKLGEELRSLRHASGLTSRDAAHLLGWHQSKVSRIETGASGVSPEDVTRLLDVYAVRDGQLRALLEVLAGSAGGGGSGWWHAYRGLIPPQYRDFISLESQASTVRTLETSVVPGLLQTAGYARAVTRASLDGLPADRLDSLVEVRLTRQRVLRAKPPLRFTAVLDEAVLHREVGGPEVMRDQLHHLTQVAQLPHVELQLLPFSVGGYVGLTSPFVIFSFPNISDLDVVVLDHLTSSLYLERKEDLEAYSSAFRTLQAHALTPDRSMELVAAIRRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5V3</accession>
    <name>A0A7K2Z5V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000002">
        <property type="protein sequence ID" value="MYW27717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="222" mass="23056" checksum="2CD75A2D836004CF" modified="2021-04-07" version="1">MVLVHGLYHRPEHFGPVADGLWAQGFEVVVPELHRGSLAADTAAVQAAVDALDRPPLLLGHSYGGSVITGVRGARHLVYLAAFVPDVGESAAALGGASPQLRDAVVPGEGPGGTTRLDPGRAADVLYDDCPGPLAARAVGLLRPQAPGCGRGIPEHHSWKLVPSTYVVCAGDRAIDPALQRTLAARCTAVREWPTGHSPFVSRPALVVDLVAELLGTVSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5W9</accession>
    <name>A0A7K2Z5W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000004">
        <property type="protein sequence ID" value="MYW27740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12190" checksum="C0EBB7F012349896" modified="2021-04-07" version="1">MLCQGVVAALQGIAALGDSDVYGTVGDYLYRFSLTSWGWIHLVLGVCAAITGAGLLKGAGWARVAGIVFASLALFAQFLFLPYAPVWSVLMIGVDIFVIWALSAYRPPAAEVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z600</accession>
    <name>A0A7K2Z600_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_00405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000011">
        <property type="protein sequence ID" value="MYW27771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW27771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="180" mass="19448" checksum="9573F7707B5F755B" modified="2021-04-07" version="1" fragment="single">MRLHVDQRHERVLQLVRERGSLRVAELAEELGMSAVTLRRDVEALAAQGLVERLHGAVVWPSGASQPAPAAAPSAEGLVVGMVVPTTEYYYADVVRGAREAVEAAGARLTIGLSRYLPDEDEAQVRRLLSTGADGLLLTPSWERGHPEPGEGLWAAEQETPVVLVERWAPLGHPVAGLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6J5</accession>
    <name>A0A7K2Z6J5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_01420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000061">
        <property type="protein sequence ID" value="MYW27965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW27965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="371" mass="41804" checksum="ED9E36216A133E2A" modified="2021-04-07" version="1">MQTRTVSTTTEHMSAIPVQNRAVHHPESRPEDLPETAAHPRASAPEAVMEEAEHAPEPREARSRTDSGGPTSDLFRQYLREIGRIPLLTAADEVELARRVEAGLFAEERLASTPDLDSRLAGDLDRLVVMGRTAKRRLIEANLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGYEPTAEEVAGQLDLTPERVTEVLRLAQEPVSLHAPVGEEDDVSFGDLIEDGDAASPVESAAFLLLREHLEAVLSTLGERERKVVQLRYGLDDGRPRTLEEIGRIFGVTRERIRQIESKTLSRLRDHAFADQLRGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6N5</accession>
    <name>A0A7K2Z6N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000064">
        <property type="protein sequence ID" value="MYW27982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="32"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="158" mass="16630" checksum="CF83F040B87CACBE" modified="2021-04-07" version="1" fragment="single">MTRDHAAAVLDVQDLSVRFRMRGGRDIAAVTDARFSVAPGECLALVGESGCGKSVLASALLGLLPANAQTTGSAVLGGDIDLLTAGERRLARTVRGRRIGLVPQSPAAHLTPVRTVRAQLEETLRELTGERGAAAVREAAARASFPADHLDRYPHELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z757</accession>
    <name>A0A7K2Z757_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonylcarbamoyl-AMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000105">
        <property type="protein sequence ID" value="MYW28152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="22800" checksum="F716F7921265F539" modified="2021-04-07" version="1">MAKYFDVHPENPQPRTISTVVDSIRSGALVAYPTDSCYALGCQLGNRDGIARIRSIRNLDDRHHFTLVCHDFAQLAQFVRVDNDVFRAVKAATPGSYTFILPATKEVPRQLLHPKKKTVGVRIPDHVVTQALVAELGEPLLSSTLLLPDEEEPLTQGWEIKERLDHEVDAVIDSGDCGTEPTTVIDFSGDEPDIVRRGAGDPSRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7B8</accession>
    <name>A0A7K2Z7B8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_02835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000122">
        <property type="protein sequence ID" value="MYW28234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="436" mass="45468" checksum="F5BAA391DA5C013E" modified="2021-04-07" version="1">MEERLAEHAAAESPPPPTPPKDGPGGPSGSGGGPSAGEPAIWSRNFTFYFVGRSAGLLSWAMLPVAVAAGLLIDGYGLETAGYSMAFLVAPFAGLVLFGGVLADRFTARRMMILADLANLVAHVLLALLFIHGIDHLWQLYSLLVVAGTANALFQPGAASTVPLVSRDVQGANGILRTSEAITGLGGPALAGTLVGFGSTGWVMVISAVAYGTSALCLFVLKLGVVPAPPAGESMWHNLAVGWREFWSRSWLWGVIVIWMFYAVLAWGPQLSLAAGVIVPEHGARAFGLVNAALGAGTIIGGLLAIRYKPQRPLAAGAVAMMAYPLYPLGIVLGWPVWMLIAAQVAVGTGIGIWGVMWSTSVQTQVPGEMLNRIHAYEVAGSVGMYPIGSALAGPAVGLFSTRTVLMVGVVVSFLTASALLVARPIRELRRVPDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7C8</accession>
    <name>A0A7K2Z7C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000126">
        <property type="protein sequence ID" value="MYW28244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13115" checksum="792E3DE50D1D772D" modified="2021-04-07" version="1">PPAARPELPKRANQEHLVPQLREAPVPRVEDEHALHDPGLMAAFRRGVDLAEAQTAQEEGTGGGYGDATGTPTALDAPLETLAPLPVRGAAEAPTPLGRPQAAHETFLPGHAVPEPRKDTTFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7P8</accession>
    <name>A0A7K2Z7P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000150">
        <property type="protein sequence ID" value="MYW28380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9708" checksum="A9947885960C282D" modified="2021-04-07" version="1">MTDQDPPRRTPASRPQQRKQMVLRLDPAVHDALARWASDELRSANAQIEFLLRRALKEAGRLPGAAAPIARRGRPPKQPPEEPAPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7V9</accession>
    <name>A0A7K2Z7V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000164">
        <property type="protein sequence ID" value="MYW28437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="13862" checksum="F058E4BB637BB618" modified="2021-04-07" version="1">APVMLATGGRAPCAVSLPALAGAKALVALDRMGMRLGPVVATPTRWSLLVAPYTLERLGELLYSKDWVPSSLRFHGEGGYLVLPPSGTGAGQVRWERAPSPGAAAPWLPDVEAVLDALVEASTSAPDGGSRLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z897</accession>
    <name>A0A7K2Z897_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA alkylation repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000199">
        <property type="protein sequence ID" value="MYW28538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="26522" checksum="B387E7BE7BE6D071" modified="2021-04-07" version="1">MDPAAAPAPAVPDSPLADAVLARLTELYAPAADLERAEGAAAYMKHIAPFLGIPTPRRRALSKVVLAGTGRPDERDCTAIALRCWGLPEREYQYFAVDYLRRFVASCSSGFLPVLHHLVTTTPWWDTVDLLAAHVAGPLVTVDPALARVMDRWIDDENLWAARTALLHQLRHKDATDTDRLFGYCLRRADHPDFFIRKAIGWALREYAKTDPTAVRDFVEGARDRLSPLSVREALKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8D6</accession>
    <name>A0A7K2Z8D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M50 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000213">
        <property type="protein sequence ID" value="MYW28617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="237" mass="25285" checksum="8537168791F4E050" modified="2021-04-07" version="1">MNSTELGDLWDRLTGIQPAPEQWLVVVTAALALIAVVPNPIWRLARNTITIAHEGGHGLVALLTGRQLSGIRLHSDTSGLTVSRGKPTGIGMILTAAAGYTAPSLLGLGGAWLLTNGRITLLLWISTALLAAMLVMIRNVYGALTVILTGTAFLLVSWLTSSDVQSAFAYTVVWFLLLGGVRPPFELQSKRRFGGAPDSDADQLARLTHAPAVLWLFLFHAVSLCSLIGGGRWLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8E3</accession>
    <name>A0A7K2Z8E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000207">
        <property type="protein sequence ID" value="MYW28588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="36434" checksum="F2EAA44144085AC2" modified="2021-04-07" version="1">MRIGTFVLAAQFPGQGPGEALHRAVRSAEAAEECGLDSVWLAEHHFVPYGVCPSATTLAALLLGRTRRIRVGTAVSVLPNHHPVALAEQAALLHLTSGGRFSLGVGRGGPWVDLEVFGGGLDAYENGFPEALELLLDWLREPRVAGRGERFGFREVAVVPRADELLADGSAQGPEVIVACTSPKTVRLAAGRALPMLLGMHCGDEEKAEMVALWRTAAREAGHPPEVVEGAAHVSAGVAQIADGPGDATETLVKTMPGWLRQGLDAHVTVDDRHRVMRDPVAYTELLCGLHPVGPPRLAADRLAATAERTGITRFALLVEGSGDLAATEENVRRLGTDVLPLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8F9</accession>
    <name>A0A7K2Z8F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR03089 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000219">
        <property type="protein sequence ID" value="MYW28639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="11744" checksum="5DDFDE870984776F" modified="2021-04-07" version="1">AGFADYAVEVPSQGDRFAPFAPVDPQAPALAVGGVELTGAQLVAKAREDAEALGLVPGSRLLTGHTYDTWEGLSTGLFAPLASGGSVVLCRHLGQLGAEGLAKRVESERVTNTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8H1</accession>
    <name>A0A7K2Z8H1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_04880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000213">
        <property type="protein sequence ID" value="MYW28618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="30446" checksum="2B6904ADF1076E04" modified="2021-04-07" version="1">MCGRYAASRRPEDLTGLFGVEKWEPTETLEQDWNVAPTKEVYAVLERPVKDADDRRPVRQLRTLKWGLVPSWSKTPEGAARMINARAETVHEKPSFRNAFAQRRCILPADGYYEWVTGAEERQLEEKKGKKRARKQPYFVTPADGSVLAMAGLYEFWRDPTLPGDHENAWWVTCSVITTEAETTPLAVAPAEGPGALADIHPRMPLMLTPDRWDTWLDPSHTGLDELRALLEPPPGGLMRAYPVATAVSNVRNNGPELLEELAAPEESTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8N8</accession>
    <name>A0A7K2Z8N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elongation factor G-like protein EF-G2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_05315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000246">
        <property type="protein sequence ID" value="MYW28701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="740" mass="78366" checksum="F021144B6FDCB4A8" modified="2021-04-07" version="1">MGEKTHAHPGAAGGVPAAGHPSAVRNVVLVGHSRSGKTTLVEALALTAGALNRAGRVEDGATVSDHDEIERRRHRSVHLSAIPVAWDGCKVNLLDTPGYADFVGELRAGLRAADAALFVVSAAQEAESVAATTRAVWEECALVGMPRAIVVTHLDTARTSFEEMTRICAETFGGDDPDAVLPLYLPVLGAEAADGHAPLTGLTGLLTQRILDYSSGERAELPPAPDQEEALTQARNRLIEGIIAESEDESLMDRYLDGGGDGIDISILIADLERAVARGAFFPVLAAAPAAEGARQGIGTVELLELITRGFPTPLERTPPTVTTPSGAPRTAPACDPEGLLLAEVVKTSSDPYAGRISLVRVFSGTLRPDDTVHLCGHGLDAAGQEPRPCHEAEVRVTSLTSPFGRQQHPADRCVAGDLVCVARLGEAETGDTLSASGDPVLIEPWSTPDPLLPTAVRAHGRADEDKLSHALARLVAEDPTLRLEQNPDTHQVVLWCLGEAHQEVALDRLRSRYGVQVDAEPHRVALRETCRGRGAGRGRHVKQSGGHGQFAICEIEVDPLPAGSGIEFVDKVVGGSVPRQFIPSVEKGVRAQAARGLSAGHPLVDVRITLLDGKAHSVDSSDAVFQTAGALALREAAADARIQLLEPVCEVTVLVPDDYVGPVMSDLSGRRGRVMGTEQRPGGRTLVRAEVPETEIGRYALDLRSLTHGTGRFARKHARFEAMPPQLAEKVRAELSDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z926</accession>
    <name>A0A7K2Z926_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_05960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000259">
        <property type="protein sequence ID" value="MYW28828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="166" mass="18172" checksum="F1A2C671A37541DC" modified="2021-04-07" version="1">MTDREETEGCRRTAAAAGGITELLDVLWESARNSTARVAAPGSTSQLRLMYLMDREGGIRMRTVCHLLAASPPSVSRMCDRLQAIGFIERMPCPDSGREVVLRLTAEGERHLRRIRERRDDLLHEAIAGMRPTERRALARGLAGLTSRLAATQEPDGGAHPGRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z956</accession>
    <name>A0A7K2Z956_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_06120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000268">
        <property type="protein sequence ID" value="MYW28858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="354" mass="38464" checksum="77515F09ED7F980E" modified="2021-04-07" version="1" fragment="single">MRRTVFNEDHEAFRETIRAFIAAEVVPVYDEWFAAGVVPREFYLKLGELGIFGIEVDEEYGGAGIDSHKYEAVIYEETARAGVSFGGSGVHTLLGLPYVKMLATDEQKKRWLPKFATGEEMWALAMTEPGTGSDVAGMKTTAKLSEDGTHYVLNGAKTFITGGVHADRVIVCARTAAPREDDRRFGISLFAVDTKSAGYSVGRKLDKLGLKTSDTAELAFVDVKVPTEDLLGEENKGFGYLGTNLASERWGIAFGAYAQAAAAVRFAKEYVQERTVFGKTVASFQNTKFELAACQAEVDAAQAVADRALEALDAGELTAAEAASAKLFCTEVAHRVIDRCLQLHGGYGFMNEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9C6</accession>
    <name>A0A7K2Z9C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_06575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000300">
        <property type="protein sequence ID" value="MYW28946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029777490" evidence="4">
        <location>
            <begin position="44"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="469" mass="47633" checksum="C834D24C07AB22FC" modified="2021-04-07" version="1">MNQPRASRARRFRLRTTSIAVGVVLAAGPVPFLAAAPASAAAAKHYDDFNGDGYRDLAVSHTYDGTLAFTDSAVLVTYGGPKGLTTKKQVIHQNSPGIPGASEYGDEFGTVLASADLNRDGYADLVVGNPSEAAGRTRVGSVTLVWGSAKGLKGGTSLPRKAAGNGHGTFGSSIATGDFNGDGRPDIATVNGGDVQLYRGGFTKSGGLGKVSRFDREGQSWYSDTIAAGKVNGDGKTDLIVTGVRGIGGTFRTETWFLKGTVAGLVSGPAKVIDGKRQQEWLDAAVGDFDRDGYGDIAVGNPVANDGRGVVIVWYGTSAGPGKRSVTLSQSTAGVAGASEAWDQFGSSLTAGDADGDGYADLAVGVPGEKVGAEVNAGGAYLFRGGKGGLAGSRSAALGKSLPGVAGETTDHDVFGYDLRLRDLNRDGRADLAVSVAGEDTVRILPGAKGGVTGAGSSVLRDVGANLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9I2</accession>
    <name>A0A7K2Z9I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_06465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000298">
        <property type="protein sequence ID" value="MYW28925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="24721" checksum="D411A506D3DF473A" modified="2021-04-07" version="1">MRILVVEDEVDLARTLHTGLTAEGYSVDLAHDGRQGLWMARTGAYAAVVLDLMLPGLNGYKVCAQLRRESNATPVLVLTAKNGEWDQTEALDTGADDYLAKPFSYPVLVARLRALVRRAAAVAPPVLAVGDLSLDVAARVCRRAGARVDLTPREFAVLELLARRAGQAVSKADLLYHAWPDDALDPNLVEARVSVLRKKVDAAFHRQSLQTVRGIGYRLVDDRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9S3</accession>
    <name>A0A7K2Z9S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Insulinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000333">
        <property type="protein sequence ID" value="MYW29089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="33"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="185"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="456" mass="48226" checksum="AB4C86F2CE60A9F6" modified="2021-04-07" version="1">MEYHPQPTPGTARPWAFPAPERGALPNGLTVLRCHRPGQQVVAVEIFLDAPLDAEPEGLDGVATIMSRALSEGTDKHSAEEFAAELERCGATLDAHADHPGVRVSLEVPASRLAKALGLVAEALRAPAFAESEIERLVGNRLDEIPHEQANPSRRAAKQLSKELFPATARMSRPRLGTEETVRRIDAAAVRAFFDAHIRPATATAVIVGDLTGIDLDALLADTLGDWSGNTAQARPVPPITADDTGRVVIVDRPGAVQTQLLIGRIGADRHERVWPAQVLGSYCLGGTLTSRLDRVLREEKGYTYGVRAFAQVLRSTGPDSGGAAMLAISGSVDTESTGPALEDLWKVLQTLAAEGLTDAERETAVQNLVGVAPLKFETAASVASTLADQVEQHLPDDYQAQLYARLAETGTVEATAAVVSAFPVDRLVTVLVGDAAQIAEPVKALGIGEVTVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9T5</accession>
    <name>A0A7K2Z9T5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000355">
        <property type="protein sequence ID" value="MYW29131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015609572.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000355.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="12163" checksum="AFA2CC1929E64F3F" modified="2021-04-07" version="1">MTTPPDDRTFRREMATAYRSGWHFIDLLTALPRRGDSLMVTLFGEPIVVVMEEDEDVRAYRCLRRPRGAPQPVRCAVRYGMIFVNLDQRDHELIASEPLSATPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA77</accession>
    <name>A0A7K2ZA77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_08240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000378">
        <property type="protein sequence ID" value="MYW29267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="3">
        <location>
            <begin position="191"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_DH" evidence="2">
        <location>
            <begin position="554"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="639" mass="66938" checksum="32DF2F72BA026CC3" modified="2021-04-07" version="1" fragment="single">KSNIGHAQAAAGVGGIIKMVHALNHAHLPRTLHAENPTSHIDWDTGTLELLTEPRDWPETDHPRRAAVSSFGFSGTNAHVILEQAPAVEEEAASTPDGPPQPVPLVLSGRDGQALADQARLLFDRLAEGTDPVADLAYALVTTRSTLDHRAVVTGTGRAELGEALTALAEGSTAPNLVRGVRRTESRSAFVFPGQGSQWEGMAAELLDTSTVFAARLAECAAALEPFTDWDLVETLRTGAPLERVEVVQPALWAVMVSLAEVWRSHGVRPAAVIGHSQGEIAAACVAGALSLADGARIVALRSRAIAEDLSGRGGGMMSVALAEEQVRELIAGYGSRVSVAAVNGAASVVLSGDGDALDEVRETVRASGGRAKRLPVDYASHGAHVEVLRERLLTDLAGIEARPAEVPFYSTVTGGLFDTTGLDATYWYTNLRQSVLFEPTTRTLLGDGHGVFVECSPHPVLLHSIEETADASGVTVTGLGSLRRDDGGPERVLTSLGEAFVAGVPVHWTSRFAGQGVRQAELPTYAFQRERYWLEPSASALRAAGTGSTGPHHPLLGTALAVAGSDEFLFATAISLATHPWLAGHTLAGSPVLSAPALVETVLAAGSVADAPVLRELTVRAHLAVPDTGELPLQVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA85</accession>
    <name>A0A7K2ZA85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000373">
        <property type="protein sequence ID" value="MYW29253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14976" checksum="019642383912404B" modified="2021-04-07" version="1">MNSLGGAHGGPQKYGSFAAAGRELGRSAEAVRERLLSDRNGAGYTALAAHTAVTWLVTYLDDHLGRTPGNTIDLHLHLNDLVAEIWTRGSAQVHEAAMRLHRSTRLRSSELRDLRALTAVRHRRIRSQRPRPTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA91</accession>
    <name>A0A7K2ZA91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family EDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000377">
        <property type="protein sequence ID" value="MYW29266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="281" mass="29268" checksum="B3D90C296AD0641F" modified="2021-04-07" version="1">MSRHVAIVTDSTAYLPRRTMERHGITAVPLTVVLGDQALEEGTEISARSLALALQKRHSVTTSRPSPEVFAATYRAAADGGADAVVSLHLSAEFSGTYDAALLAAKDAPIPVRVVDTGMVAMALGFCALAAAESAEVGGSPDEIVAAAEKRAAGTSAYFYVDTLDYLRRGGRIGTAQALLGSALAVKPILQLDGGRIEMLEKVRTASKAIARLEEIVAERAGQASVDIAVHHLAAPERAERLAERLRERVPGLADLHVSEVGAVIGAHTGPGLLGAVISPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAD7</accession>
    <name>A0A7K2ZAD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_08435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000385">
        <property type="protein sequence ID" value="MYW29304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029874000" evidence="3">
        <location>
            <begin position="35"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="458" mass="49367" checksum="95FDC96BF25494C8" modified="2021-04-07" version="1">MRSIRRTKHLGLIGMLLIAVAFAGLQLTAVTGRASPDTKNYLSYALSLSGESRAEAGRRAIDYSCASQQHGPLDSIPWTSRKVAGESEEQCVRRLNDSVAHWSRNGNTSGMIAPFANHRFMAIFEARPGYPLFLVPFVTVFGAMWGLWLAGLVVALAGSVCVLLTLRCAGASRRAGLAGQALYLALPTGTVAMNPLSDGLSLALGTAVVLGCTLLALDRPRTGTALVVGGLALMFPVRYSQALLLAVVLAAGFALRWAWLRRRRRPSLRTGQAAVLCGALAVAVYAGVHLLSWPTGQDSAQDLLTDHYRFPDLPDPWPEFLVQERIFWTAWLHRQATYPVLPVLLALSAWALLRRRSAVLPIALAAASAGILNQAGHPNLDQLLGHRLIVFVWLLPVLAVPLLLDREPTPSTGGEGAQRPPLKRRRERDPAASRAGGNGSSGRPQDPPPAVRGRSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAF5</accession>
    <name>A0A7K2ZAF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lantibiotic dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000383">
        <property type="protein sequence ID" value="MYW29282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="13290" checksum="EFA1043135B13743" modified="2021-04-07" version="1" fragment="single">MSDHTNPSVVRPAFMARVAGLPVESVQGLRCPESRRWADEVLDDSARLRLLAEKAGDRLHDLIGGSDDEPLRRALLKLRRDIFNGRLPAPDTADRALALVRGLDPAAASTLTDWLTGRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAK8</accession>
    <name>A0A7K2ZAK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_08915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000409">
        <property type="protein sequence ID" value="MYW29397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029680531" evidence="2">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="9607" checksum="5BDDAE9BA6E30717" modified="2021-04-07" version="1">MYRTSPHPKPRRSPRTATAALATGIALAAVTLLAGPAAAAPQRTAPATPATHTESAGVPEHVTRLVCTELAGAIGHLPPESGPVRVCKLVNGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAN3</accession>
    <name>A0A7K2ZAN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000402">
        <property type="protein sequence ID" value="MYW29325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="10"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="33096" checksum="175FB823D939FB03" modified="2021-04-07" version="1">MGVNVSVVAVDAGNSKTDVALIGEDGTVLSTARGGGFQPPYVGVEAALDVLAGALAEALAALPGPVGSVGHVSACLANADLPVEEAELAEALEARGWGTSVQVRNDTFAILRAGVDEPRGVAVVCGAGINCVGMVPDGRTARFPAIGRMSGDWGGGAGLAEEALWFAARAEDGRGEPTELARVLPGHFGLDSMYALIEALHRGTIPLTRRHELTPVLFATAVAGDPVAGALVERLAQEVVAMASVALTRLGLLEEEAPVLLGGSVLAARHPQLNDRIAELLAARAPKAVVRVVSEPPVLGAALLGLDVTGAAPEVHRRLRAHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAR3</accession>
    <name>A0A7K2ZAR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000418">
        <property type="protein sequence ID" value="MYW29446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="384" mass="42483" checksum="BD1888B7BF3A8F87" modified="2021-04-07" version="1">MDVQKKLDEIVEAVGNARAMPMSASCVVNRAELLAMLEEVREALPGSLAHAQELIGGQEQFAEQARQEAERIIQSAHAQRSSLIAETEIARQSQSEADRILSEARREAEEVRAEADDYVDSKLANFEVVLTKTIGSVDRGREKLLGRGQGLDEQGYQDPDFAEAPERSADPETLKQRADAYVDAKFGAFEAVLAKTLEAVGRGRQKLHGRVASDDLGAHMAAQDAAGAQGHTSDADYLAGLAELATPAPQQAPQQPLYQEQQPEYQGRPPQAEPSYAQAEYGQGEYGQAEYAQASYGYQEQQQPHQQGQDPYAYQQVPDPYAAYQQPAYDPNQYPPQPQAQPEYDWQQQPQVPAQQNQGALDETSLFDTSMIDLEQLRRYEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB61</accession>
    <name>A0A7K2ZB61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional 3'-5' exonuclease/DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_09900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000456">
        <property type="protein sequence ID" value="MYW29579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="2">
        <location>
            <begin position="212"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="455" mass="49655" checksum="5C205104046D29E0" modified="2021-04-07" version="1">LENAPVPPDPPARSAEPGSQSSLFEPPSGPEVPFEGLLRVYADQVRRHDTAEHPDRMRLLTASESAGMLVAAEMHRAGLPWRADVHREVLHGLLGERYAGGGEPRRLAELADEVSAAFGRRVRPDLPADVVKAFSQAGISVKSTRRWELAELDHPAVEPLIAYKKLYRIWTAHGWSWLQDWVREGRFRPEYQPGGTVSGRWTTNGGGALQIPKVIRQAVVADEGWRLVVADADQMEPRVLAAISRDRGLMEVAGHDGDLYKALSDRAFHGDREHAKLALLGAVYGQTSGDGLKNLAALRRRFPLAVAYVDDAARAGEEGRTVRTWLGRTSPPVALAGQDEEAGIPQEGGEAVSDGGLARARGRFTRNFVVQGSAADWALLLLAGLRRALHEQGLRAELVFFQHDEVIVHCPAEETDAVTEAIRAAGELAGRIAFGETPVRFPFTTAVVERYSDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBC1</accession>
    <name>A0A7K2ZBC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000470">
        <property type="protein sequence ID" value="MYW29656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="24684" checksum="9EEBD3608580C1C8" modified="2021-04-07" version="1">AEGACVVVADLDAERAAAVAEELGGPDQAVAVTVDVTSEAQVVGAFTAAALAFGGVDLVVNNAGISISKPLLETTVRDWDLQHDIMARGSFLVSREAARMMRAQQLGGDIVYIASKNAVFAGPDNIAYSATKADQAHQVRLLAAELGEHGIRVNGVNPDGVVRGSGIFAGGWGAQRAATYGIEEENLGAFYAQRTLLKREVLPEHVANAVFALTGGDLTHTTGLHIPVDAGVPGAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBC4</accession>
    <name>A0A7K2ZBC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isorenieratene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000477">
        <property type="protein sequence ID" value="MYW29671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="436" mass="48400" checksum="A6E9E50C59D20DCB" modified="2021-04-07" version="1">GTDVTMSRGFHAFFRQYYNLRGLLRRVDPGLDSLTRLPDYPLRHSSGLHDSFARVPRTPPLSAMGFVALSPTFGLRDLARMNPRAALPLLDVRVPEVYDQLDSLSAHDFLTRIRFPEAAHHLAFEVFSRSFFADPRELSAAELVLMFHIYFLGSSEGLLFDVPDEPFPTALWDPLQRYLAGHGVDVRTRTPVRQVRPLPDGGLDLTTDDRTTRYDALVLALDSGGLRRVVGASPELGDAEWRAGIERLRTAPPFLVSRLWLDRPVAYDRPGFLGTSGYGPLDNVSVLDRWEGEAARWARRTRGSVVELHAYAVAPDADRGAVQAEALRQLHRIYPETQSARIVDERHVWRADCPMFPVGGYRDRPGVRSPDPAVMVAGDMVRTGLPVALMERAATSGFLAANALLERWGVHGQTLWTVPRAGRSAALRRLAALGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBI3</accession>
    <name>A0A7K2ZBI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000484">
        <property type="protein sequence ID" value="MYW29693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="34981" checksum="E286CF2716E404FE" modified="2021-04-07" version="1">MATEFGDSVRRALQQRGVSLRGAARDLSYDHAYLSRVLSGRQAPSAPLAASLDAYLRAEGALVELADALSGDGEGRLHRMVERPTRIDRQAVNAVSDVLAAQRRLDDSLGPVPLLRSISAQADAARALLREARGPHRDQFAAVVAEWVQFEGWLYASARDDGRARVLLDEALELADEVESPLLTAQALNFRGYLARQQARPRAVTRWFLAAFHTPGAHPAQRMGDAAQAAQGYAELGESDEARRLLEEAANLTDAAADQPPGTAYWLTPSFQRLNLGLAHLALGDHVDAADHIRSGLDGLPADQQGAAWSVEYRDALRRAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBN7</accession>
    <name>A0A7K2ZBN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermidine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000492">
        <property type="protein sequence ID" value="MYW29749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="18149" checksum="958B66160BB2320C" modified="2021-04-07" version="1">RMVREHLPLPEESGISVHAADARARLEAAPPGSADVIVADVFGGSRVPAHLTSVEYARAAGRVLRPDGVYAANLADSAPFAFLRSQLANFAAVFGELALIGEPAVLRGRRFGNVVLLASHTPIATAPLTRRCAADAFPARVTDGAALVRLIAGARPVADVNAVASPEPPDGAFSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBP1</accession>
    <name>A0A7K2ZBP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_10790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000492">
        <property type="protein sequence ID" value="MYW29753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="251" mass="26974" checksum="F70A39427A99F649" modified="2021-04-07" version="1">MPKNRNTFSFLARRRRRAASWVVHRGWAWAQEAGAVTAEHPGRLRFGAIGEGTRLAFPQGTVFGEPWIQLGGHCIIGEQVTLTAGMMPDLDLGPEPILTLGDGVVLGRGSHVIADTTVSIGSDTYCGPYVYITSTNHSYDDPHEPVGKQWPRMEPVEIGPGCWIGTGAVILPGARLGRNVVVAAGAVVRGEVPDHAVVAGAPARVVRSWDPEKGWQPPLRTPAPVPIPKGVTPEQLLALAELEKEQEPDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCE5</accession>
    <name>A0A7K2ZCE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000560">
        <property type="protein sequence ID" value="MYW30030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="60" mass="6338" checksum="26C2EFDCBDACA63C" modified="2021-04-07" version="1" fragment="single">MYDPTRLAALVAVAETGSITRAAAHLGYTAPALSQQLAKLEREAGATLLVRHHRGARLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCK3</accession>
    <name>A0A7K2ZCK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_12410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000578">
        <property type="protein sequence ID" value="MYW30063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="242" mass="24765" checksum="F08B07A24BE5FB9C" modified="2021-04-07" version="1">GQPGWGQQQPGIPGGGGPGAAGWPPQGPGAQPPRKKRTGLIVGIVAGAVVLAGGIAFGVSQVVGKTADAAFPDAEYKLVLEQKLLDGEFTLAQDLSSTEGKKIEKMYDPTVRDARAVVGQYSSADGGALVISGMYGRFTSPEVMTGKMMDGGAAGDGATVVVPPKKFTPAGFDITMECQVLQSVKSGIKANVPMCAWGDDNTGVSVGIIRAETALKDPSAIDLEAAAVETAKVREEIRQPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCU5</accession>
    <name>A0A7K2ZCU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-associated oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000603">
        <property type="protein sequence ID" value="MYW30177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="488" mass="52470" checksum="26AF52FD216EFFA3" modified="2021-04-07" version="1">MTPAERRVRDAFASGAPVDFRTGSADDPEDGVGWGPGRTVRAEVLRSLLLGGERRPGEVAALRVTGARITGTLRGRYAVAECAVLLAGCHFDETPDLCGAQLRQLDLSGSVLPGLDATAVRVDGAVRLAGCRIAGPVRLGGARIAGALVLEGARIGVPEDGAAGERDEPVLRLNHAVVEDDLWWPRLVVHGEARIDGAAVTGQIRLDDSVLKNPGGTALQAENLTVGSDLHAMRVRVRGRVNLRGCRIPGQLNFAYAALSHPEGVALRASSMAVGELWLREAAPVEGVVNLRRSQIEVLHADPSVWPSVVQLEGLTYTSLLPHLPAARRLPLLEREEQGYVPSAYEQLTAAYRRIGDDDAARTVLLAKERRRRGTLPAYARLWGYLQDAAVGYGFRPVRAAGWLLSLLLVGTVAYAADHPAPLKDDEAPGFSPLFYTLDLLLPIVDFGQEKAFNPQGWYQWLAYLLIVTGWLLATTIAAGVTRSVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCZ0</accession>
    <name>A0A7K2ZCZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_13270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000613">
        <property type="protein sequence ID" value="MYW30230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="271" mass="30306" checksum="F1EE8E36679F519D" modified="2021-04-07" version="1">MRFNLIGPFEVVTDDGRIYHPGTPKVCQTLALLLTRPNEIVTAESLIKELWGERPPRSAVTTLQTYVYHARRMFVNERLVESGRTLIVTSAPGYAIQVDDSEVDIRVFEQLVAQGRDRLAAGDPAAALDHINRALALWRGPALSNFPAGDVLAGHIVHLEELRIRAFEIRIEAEGRLGRQGDSIPGLRRLINDYPLNEWFHCQLISALGSAGRRAEALHAYQHVRRLLAEELGLEPSPQMQRLQSRLLGADTMDRVPLPRGQELAVHEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD87</accession>
    <name>A0A7K2ZD87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000639">
        <property type="protein sequence ID" value="MYW30279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="23762" checksum="F83ED2A4E69642B0" modified="2021-04-07" version="1">DWEYPNACGLTCDTSGRDAYGELLGELRKSFGNDNLITSAITADGSEGGKIDAVDYAGAAQHLDWYLPMTYDFFGAFAAQGPTAPHSPLTSYPGIPTEGFNSDAAISKLKSLGIPSEKLLLGIGFYGRGWTGVTQTEPGGSATGAAKGTYEDGIEDYKVLKGSCPVSGTVAGTAYAHCGNDWWSYDTPETIGTKMEYKNEQGLGGTFFWELSGDTTNGELIKAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDD4</accession>
    <name>A0A7K2ZDD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000660">
        <property type="protein sequence ID" value="MYW30377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="349" mass="38648" checksum="B3AE79D722D23E24" modified="2021-04-07" version="1">MELDLDAFLDPAKSLNEGALLHPDFSTDTWYWLSYAESGLYPADRPLADFTAEEWQLLLRGELPEKLRLEWQGNTLNIAYEGLVDKFTRLYIKKEDMSERSRRVFERFVRSAPCRACDGSRLAPAVRASRIAGCHIGELATMEARRLAAFLAELELPQVKPVLDDLITRLRHLDDIGLGYLSLDRQTRTLSGGESQRIKMVRHLSSDRTGMLYVFDEPSVGLHARDVHRLKRLLVELRDEGNTVSGANGHNLKDVSVDFPTGVLTVITGVAGSGKSSLVNDDFLSRCPDAIVIDQTAVTANRRSYSATYTGLMDPIRKMFAKANGVSASLFSANSKGACPNCQGLSVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDI6</accession>
    <name>A0A7K2ZDI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000660">
        <property type="protein sequence ID" value="MYW30379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="2">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="101"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="28223" checksum="9701930C153AEC8A" modified="2021-04-07" version="1">MAGVITASEPSWTSPFTGLSPRQFGKPVTVLRREGADSVRRGRPWSLPLEDRALLVAAYWRTNLTMRQLAPLFGVSKSAAHRIIDHLGPMLALQPRKRFAKDTVLIVDGTLVPTRDHTIAAQSKNYRYSTNHQVVIDADTRLVVAAGRPLAGNRNDCKAWDESGAKAAVGRTTTIADGGYPGTGLVMPHRPREGEELPEWKQAHNKSHKQVRARVEHVFARMKTWKILRDCRLKGDGVHHAMLGIARMHNLALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDQ4</accession>
    <name>A0A7K2ZDQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_14665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000690">
        <property type="protein sequence ID" value="MYW30490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="27"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="413" mass="44819" checksum="45C342F94B22AC0C" modified="2021-04-07" version="1">MVGMPSVLPDGEPVPDDGALPRHALEGAADRPLGFYLHVPYCATRCGYCDFNTYTATELRGSGGALASRDNYAAHLIEEVRQARKVLGDDPRPVRTVFVGGGTPTLLPAADLVRMLGAIRDEFGLAEDAEITTEANPESVDPAYLTALREGGFNRVSFGMQSAKQHVLKILDRTHTPGRPEACVAEARAAGFDHVNLDLIYGTPGESDDDWRATLDAAIGAGPDHISAYALIVEEGTQLARRIRRGEIPMTDDDAHADRYLIADEAFAAAGFDWYEVSNWATTEAGRCLHNELYWRGADWWGAGPGAHSHVGGVRWWNVKHPGAYAQALSEGRSPGAGREILAEEDRRVERILLELRLREGCPLDLLKPDGLAASRRALTDGLLDPVPYAEGRAVLTLRGRLLADAVVRDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDR1</accession>
    <name>A0A7K2ZDR1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mg-protoporphyrin IX chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_14515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000676">
        <property type="protein sequence ID" value="MYW30462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="28"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="414" mass="43430" checksum="773AF78F9A098134" modified="2021-04-07" version="1" fragment="single">MSTPYPFTAIVGQDDLRLGLLLNAVSPAVGGVLVRGEKGTAKSTAVRALAALMPEVSVVPGCRFSCDPVSPDPACPDGPHAEAPGVSRPARTVELPVGASEDRLVGALDIERALSEGVKAFEPGLLADAHRGILYVDEVNLLHDHLVDLLLDAAAMGASYVEREGVSVRHAARFLLVGTMNPEEGELRPQLLDRFGLTVEVAASRDTDERVEVVRRRLAYDDDPEGFAARWAEEETTLRERIAAARALLPRVVLGDGVLRQIAATCAAFEVDGMRADIVMARTATALAAWAGREEVTADDVRQAALLALPHRRRRNPFDAPGLDEDKLDRTLDEAAGDEGQGNDDDPDPGPDGGGDGGGGGGVPPQADGDRTPPQGSEGDDTPSQAPDSAPDAPGPSAGAEQQPVAAAEPFRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDS7</accession>
    <name>A0A7K2ZDS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000667">
        <property type="protein sequence ID" value="MYW30425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="180" mass="19733" checksum="B22D85EB731B7A1C" modified="2021-04-07" version="1">MPSERLMRIHSPEFQAMAARVLRATELTSRLNVLPFEDEDGKAALFAQILGRPLPPRTTVYPPFFTDHGLHLDLAERVFINQNCTFLDYAGIRLDERVMVGPKATFITSGHPVDPEERRHYLTGGPIHVQENVWIGAGATILPGVTIGRDAVIAAGAVVAEDVPAASLVTGPKATESRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEC3</accession>
    <name>A0A7K2ZEC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_15690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000732">
        <property type="protein sequence ID" value="MYW30682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045697">
        <property type="entry name" value="DUF5919"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041334">
        <property type="entry name" value="HEPN_SAV2148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19319">
        <property type="entry name" value="DUF5919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18725">
        <property type="entry name" value="HEPN_SAV2148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_SAV2148" evidence="2">
        <location>
            <begin position="26"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5919" evidence="3">
        <location>
            <begin position="250"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="411" mass="45517" checksum="FAB534C89167F5CF" modified="2021-04-07" version="1">MSSGGFELPPGDAGHEGEATDAPPGAVSLAQPMEIGAELDWGAEAWSEVRTRAQRAGRAYIWLNLVEQRLRSVVAAVLRPIYEPVHGDDWVVAAAGPAGQEWVQRAVAVREVSRRKGYLLDPADDNVLSFLTLPQLRELMVQHWPCFEPYFDDRRDVELALDELEVTRNVVSRNRALNEAVLAQAERASARLLDILGSGASVPSADRLPVDAVEELVGDRYADVVSVHPDRVRLQRQLPAEDLFGGARRLDAIGIGLNLLVQNFSGRRLVRLAESGCRVRLLFINPASSAVKRRERELGLKKGELSRSVEMNILHMRRVRSKLRDPGAFEIQVFDETPRFTAYLVDGDGADAVGVVQPYLRRARGMEAPVLVLRGGGRRTVVRAGQDSEGGLFETYREEFESVWTDSRPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF27</accession>
    <name>A0A7K2ZF27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000777">
        <property type="protein sequence ID" value="MYW30885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="22384" checksum="F99BD87974A7C4BB" modified="2021-04-07" version="1">MQIAITLFDRFTALDAVGPYEILSRAPGAEVVFVAERPGPVANDSGSLQLVAHRTFAEVPSPDLVIVPGGPGQSDQMENATLLDWLRAVDATTTWTTSVCTGSLLLAAAGLLKGRRATSHWLALELLQGFGAEPTGERVVSDGKYVTAAGVSSGIDMGLTLLGRIAGDDAARSVQLLTEYDPQPPYDCGSPEKAPAALVEEWRARSRHLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFE1</accession>
    <name>A0A7K2ZFE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000824">
        <property type="protein sequence ID" value="MYW31052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="102"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="497" mass="54206" checksum="0FFFAD85CE828B56" modified="2021-04-07" version="1">RGTWSSHRFEPIGGCAVCLPLPPDGAEVAEAAFGPAARRAPRPPADPVSLREPNSLTDVAGLREVLFDERFGPVHQILRTEESVHSLTSAYVTYGRHMRDGGYGRSRDFASSERIALFEGAERLASMSPTGHRTALRAPYAELGPEQAVDPVRLGLPDPAHHGHPASATVPYTPDLELDWVHGWSLTRDRTTAVPEHVAYWDASPGRPRVVYECSNGCGLGNSPVEAALYGLFEVAERDAFLMAWYARTPLRRITVPAEDAEVAHLVDRAALAGYRVALFDATNDFRIPAVIAVALHRGEPATAPGAFVAAGSHHHPLAAIRSALAEVVTNVVNAVHRHRAEPETFGRRRLLPMLERPELVTTLDDHVAVNTLPEARPRLDFLDPDGPETDWRDIWPAASAPLPAPDVTALLEQTVTRLAGLGLEVVAVPLSESVVRDRLGLHTAKIVVPGSLPMTFGHVNRRTLGLDRLLDVPFRLGRVPRRARHDELALHPHPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFR2</accession>
    <name>A0A7K2ZFR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000857">
        <property type="protein sequence ID" value="MYW31139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="380" mass="39890" checksum="FC7BABA38EEF6054" modified="2021-04-07" version="1">MGMTGRRDLNEGNATTAQGRSGVGRVLAGLRLAAVSGVIGAALAALVVGVILKDVPVLATGGGFLTLLVLLAFLGGRRGAGRDAPPARRTALARIEDLRATGGETADVPVTFRLTVAPEPEDERPAYRVKISQSINLVDIPAYRPRGIAVVEYHPEKPWDVRIVTRPTPEWSRRAEEAEIDSAPESTLVRDPDGGSGAWCLLVLVGLLAGAALVVLSFRGELFASGDTGESAAKEPSSSSASRTFSTSTTVSGPSSSLLSFGRMRVTAMELEARVDSAYVTSLRIEDHRMAVRGDSARPLAETVHLPSLPYELFPGLVREARATLGVRDAESWRIDVTPGGGAGVGPRVRVTVSGTEGTAHLDADVTGRITDRRAVGETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFV4</accession>
    <name>A0A7K2ZFV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4230 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_18655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000869">
        <property type="protein sequence ID" value="MYW31241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="234" mass="24523" checksum="20EE4A82E5E4AB59" modified="2021-04-07" version="1">MTSSDATTDTAPQSGKTPTPRPGRGLLKAVGVCAAVLALIFAAGKLSLLPGLDSLFGEETRDRSGPAVLKSIQDMSAYEAASGNFQVVVDLEKDAKFLPDAVRGTRTLFVGAGTVGASVDLGKVTEDGVVINEERTTAEIRLPHAVLGKPALDPDRSYAVSKQRGLLDRLGDLFSDNPSSEQAVNQLAVRHIGEAAKESGLTARAEKNTADMLKGLLGSLGFERVTVRYGDDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGD2</accession>
    <name>A0A7K2ZGD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sucC</name>
        <name evidence="9" type="ORF">GT040_19610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000914">
        <property type="protein sequence ID" value="MYW31421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="319"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="393" mass="41281" checksum="67EE4A19EC68F32C" modified="2021-04-07" version="1">MDLFEYQARDLFAKHGVPVLAGEVIDTPEAAREATEKLGGKSVVKAQVKVGGRGKAGGVKLAADADEAVARATDILGMDIKGHTVHKVMIAELSPEIEAEYYVSYLLDRTNRTFLAMASVQGGMDIEEVAEKTPEALAKVPVDSNSGVDIVKAREIVAQAKFPAEVAEKVAEVLVTLWDTFVAEDALLVEVNPLVKTKDGRILALDGKVSLDENADFRQPDHEALEDKAAANPLEAAAKAKNLNYVKLDGEVGIIGNGAGLVMSTLDVVAYAGENHGSVKPANFLDIGGGASAEVMANGLEIILGDPDVKSVFVNVFGGITACDEVANGIVQALALLESKGEKVEKPLVVRLDGNNAELGRKILSDANHPLVQRVDTMDGAADKAAELAAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGN0</accession>
    <name>A0A7K2ZGN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_20060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000935">
        <property type="protein sequence ID" value="MYW31507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029836536" evidence="2">
        <location>
            <begin position="33"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="64"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="31039" checksum="36DA826967A2DDA1" modified="2021-04-07" version="1">MHLATRSLVTTVTAVCSAVALCAGLTGCAPQAEEKPKASGASGQAGGTAGACAPGGLATEVEGKLTVGTDRPAYAPWFSDDEPSNGKGFESAVAYAVAKQLGYGRDAVVWQHTPFNSAFAPGAKKFDFDINQVSISESRKKAVAFSSGYYDVRQAVVALKSSKAAGAKSVADLKDVKLGAQVGTTSLEFINDLVKPATKPAVYQRNDFAKSALKTGQVDAIVVDLPTAFYITGAEVPEAKVVGQFPDSADKPEQFGLVLDKESALTSCVSGAVDALRKDGTLAALEKEWLSDAVDAPVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGN5</accession>
    <name>A0A7K2ZGN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coagulation factor 5/8 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000941">
        <property type="protein sequence ID" value="MYW31523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="17439" checksum="63B7D37BD4990BEF" modified="2021-04-07" version="1">DHGEGWGWETNRADYGVRVNGDDVLATGLFVEHFNKYDVEWYGERGRTIFFQNEKAYDAPNQEAIQNGDTKGYAAYRVDDSVNQHEGWGMGSYCYYNVDPTIVQGHGFKAPVKPGVKFHSLIVVSLGGNGQYEHVINETGSPTSGTETIPSQVVNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGW9</accession>
    <name>A0A7K2ZGW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000968">
        <property type="protein sequence ID" value="MYW31590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="427" mass="45543" checksum="39535158AA592B02" modified="2021-04-07" version="1">MSGLYERHLAVSPEWLALYYRHPIELTHGEGRYVWDADGNRYLDFFGGILTTMTAHALPEVTKAISEQAGRIIHSSTLYLNRPMVELAERIATLSGIPDARVFFTTSGTEANDTALLLATAYRRSNQILAMRNSYHGRSFSAVSITGNQAWSPTTLSPLQTLYVHGGVRSRGPYAELSDDRFIRACVADLEDLLGHTREAAALIAEPIQGVGGFTSPPDGLFAAFRQVLDRHGILWISDEVQTGWGRTGEHFWGWQAHAEHGPPDILTFAKGIGNGMSIGGVVARAEVMNCLDANSISTFGGSPVTMAAGLANLSYHLEHDLQGNARRVGGLLIERLRGIAAGSAAVREVRGRGLMIGIELVKPGTDEANPEAAAAVLEAARAGGLLIGKGGGHNTSVLRIAPPLTLTVAEAEEGASVLADALHAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHJ2</accession>
    <name>A0A7K2ZHJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001019">
        <property type="protein sequence ID" value="MYW31807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045969">
        <property type="entry name" value="DUF5925"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19347">
        <property type="entry name" value="DUF5925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="178"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="364" mass="39339" checksum="E35B14EB71D11C4D" modified="2021-04-07" version="1">MSANPESALPIRLTVDDSDSPSDVVDALFLGRFATGEQPYSHSSSLDRVKTGATLLPPHASVLRSARDDDRSATLAEGDGWTLLISRWSRGADVTVTATSAELAEKILGQATDGAQDEPEPQPDNVTMGFWYVSPRRGPYRTTRQISAGSWDEVRPNYTAPVADAMDRLMKVTPDDIAGRLLLLHGPPGTGKTSALRTLARSWRDWCQVDCVLDPERLFNDVGYLMDIAIGEDDGTAKGRWRLLLLEDCDELIRGEAKHTAGQALSRLLNLTDGLLGQGRNVLVGVTTNEDLERLHPAVVRPGRCLARIEVGPLTRSESVAWLGTEEGVSREGSSLAELYALRRGTGPASVPKQDAGADAGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHY8</accession>
    <name>A0A7K2ZHY8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">purL</name>
        <name evidence="9" type="ORF">GT040_22510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001062">
        <property type="protein sequence ID" value="MYW31971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="211"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="454"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="585"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW31971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="749" mass="79653" checksum="A9737AEF2B0E1110" modified="2021-04-07" version="1">MSLDTVKHAAETSDAEQPWKELGLKEDEYARIREILGRRPTGAELAMYSVMWSEHCSYKSSKVHLKQFGEKVPANDAMLVGIGENAGVVDVGQGYAVTFKVESHNHPSYIEPYQGAATGIGGIVRDILAMGARPIAVVDPLRFGAADHPDTKRVLPGVVAGIGGYGNCLGLPNIGGEVVFDSCYQGNPLVNAGCIGVMKHEDIHLAQASGPGNRVILYGARTGGDGIGGVSVLASETFESTGPAKRPAVQVGDPFQEKLLIECTLEIFKEKLVAGIQDLGGAGLSCATSELASAGSGGMRVELDTVPLRDSSLSPEEILMSESQERMCAIVEPQHVDRFLEICEKWDVIATVIGEVTDGSQLEIFWHGEQIVDVPPRSVAHDGPVYHRPFARPSWQDALQADDAGKLPRPQNGAELKDQVLKLVASPNQASKAWITDQYDRFVQGNTVLAMPEDAGMVRIDAESNLGVAMATDGNGRYAKLDPYTGAQLALAESYRNVAASGAKPLAISDCLNFGSPEDPDVMWQFAEATRGLADGCLELGTPVTGGNVSLYNQTGETAIHPTPVVAVLGVIDDVNRRTPVAFAEEGQLLYLLGDTHEEFGGSAWSEVVHNHLGGLPPKVDLGREKLLAEILISASRDGMIDAAHDLSDGGLIQAVTESCLRGGKGARLVVPDGLDTFTFLFSESAGRAVVAVPRSEELRFNDMCGARGLPVARIGVVDGEEIEIQGEFSIPLSELRTAHEATIPALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHZ4</accession>
    <name>A0A7K2ZHZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_22320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029882546" evidence="3">
        <location>
            <begin position="32"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="422" mass="43170" checksum="9F6A5E8D5C8B9891" modified="2021-04-07" version="1">MTVRRSAAALATTAVLLGAAAPFAAAPVAVAAPTPSPSVQLPLGLYGTTDPTYDGVWRQSLAFLAQKIEYVTPSKQSVDWLLEQQCDSGAFTSYRDDASVPCDASTVMDTNATAAAVQAFVELGQHRDAADNGADWLKSVQNEDGGWGYNPGSPSDANSTGVVIGALARTGVPINELTTADGSTPYTALQALAIPCDKKDGGAFAYQPGKKGELVANNDASAAATLGLLGRGMAVGDSNAVKDPVCTKGDDLTAEQSAQNGAHYLAATLAASPYLEQPPMPGAEESEPQPDFGNTADTVVALAASGHKDKAAASVEWLEKNSKDWAQQGGPAATAQLIFAAHATAADARDFGGVDLVAQLNATGPAPAVTALPSPTPTGPQPSSGTESEDSGLGLWWLVGLGLFFGAGIGFLLSMRRKKQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI55</accession>
    <name>A0A7K2ZI55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001069">
        <property type="protein sequence ID" value="MYW32031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="102" mass="10937" checksum="A28337E5BA353582" modified="2021-04-07" version="1">GRLGIACAAPVLRHVYRETSSSHLRGRAARALAATDPTFATGFAVECLWDCEETTREVAALHAETGDIRVAERLRRLAADPAEEAEVQTAVRSRIGPDAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIN7</accession>
    <name>A0A7K2ZIN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001110">
        <property type="protein sequence ID" value="MYW32185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="69"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="23471" checksum="7BDC4430598A4CEE" modified="2021-04-07" version="1">MASIVRVQAPSGNRALFITTLAVPLTGWTVHAVSLHRKLAAARKDPLTGLLGRDGFTTRARQITDRYGDAALVVLVDLDHFKQINDGPGGHAAGDRVLAVTAQRLTAWAGSRGAVGRLGGDEFAVAVRIGPARRELRLAQLVQLLAQPVEVEDGVLVDVAASIGAASPDVLGTTDLSVLQRAADAAMYAGKHTGRAVLAGPQHATVPSINGRRAGRPGTHTLGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ53</accession>
    <name>A0A7K2ZJ53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_24635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001153">
        <property type="protein sequence ID" value="MYW32367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="133"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="21586" checksum="EF8860366F9919C2" modified="2021-04-07" version="1">MNEAVQISGVPSPGPDLQELLVRVARGDQEAFAKVYDAVSGPVLGLVRSVLRDPAQSEEVAQEVLVEVWRTAPRFQSSRGSAMNWVLTLAHHRAVDRVRSAEASAAREHKAALLDRTPAFDVVSEQVETRLEREQVRRCLRTLSELQRQSVTLAYYQGLTYREVAELLTVPLGTIKTRLRDGLIRLRDCLGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJI0</accession>
    <name>A0A7K2ZJI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_25355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001195">
        <property type="protein sequence ID" value="MYW32506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073881150.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001195.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="138" mass="15197" checksum="1C09046F19F154C5" modified="2021-04-07" version="1">MEIKLAQTFIAVDDHDKALTFYRDVLGLEVRNDVGFEGMRWVTVGSPAQPDVEIVLEPPLADPNAPAADRQAMAELLAKGLLRGVIFSTDDVDATFERIRAAGGEVLQEPIDQPYGVRDCAFRDPAGNMLRFNQPRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJU0</accession>
    <name>A0A7K2ZJU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">infB</name>
        <name evidence="10" type="ORF">GT040_25950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001206">
        <property type="protein sequence ID" value="MYW32622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030569379.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001206.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="106"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="165"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="613" mass="65905" checksum="4A51DF1BD06D3403" modified="2021-04-07" version="1">MQAPSVGGVMLPRGNGQAVRLSRGASLTDFAEKINANPASLVAVMMNLGEMVTATQSVSDETLRLLADEMNYVLEIVSPEEEDRELLESFDIEFGEDEGGEEALVSRPPVVTVMGHVDHGKTRLLDAIRKTNVVAGEAGGITQHIGAYQVSSEVNGEDRKITFIDTPGHEAFTAMRARGAKSTDIAILVVAANDGVMPQTIEALNHAKAAEVPIVVAVNKIDVEGADPTKVRGQLTEFGLVAEEYGGDTMFVDISAKQGLNIEALLEAVVLTADASLDLRANPEQDAQGIAIESHLDRGRGAVSTVLVQRGTLRIGDTMVVGDAYGRVRAMLDDNGQNVQEAGPSTPVLVLGLTNVPGAGDNFLVVDEDRTARQIAEKRAARERNANFARKGVRFSLENLDEALKAGLVQELNLIIKGDASGSVEALESSLLQLDVGEEVDIRVLHRGVGAVTESDINLATGSDAIVIGFNVRAAGRAEQMAEREGVDVRYYSVIYQAIEEIEAALKGMLKPEYEEVELGTAEIREIFRSSKLGNIAGVLVRSGEVKRNTKARLLRDGKVIAENLNISGLRRFKDDVTEIREGFEGGINLGNFNDIKIDDVIATYEMREKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK48</accession>
    <name>A0A7K2ZK48_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_26415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001233">
        <property type="protein sequence ID" value="MYW32708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509728.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001233.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="29071" checksum="8C3EDA3FAA33599E" modified="2021-04-07" version="1">MKLLPLFLRRPIEAVYERRLASTLVGLPRPQHVGIMVDGNRRWARKAGHTDVREGYRAGGAKVTTFLGWCTAAGIEHVTLFMLSDDNLGRPAEELGPLIEVIEETVRDITAEGRDWEVQVIGSLDLLPGASAQVLKEATAATTGRGGLKVDVAVGYGGRREIVDAVKRAFEEHMAAGGDPAELVARFEIDDISRHLYSPVADHTDFIIRTSGEQRLSGFLLWQSAYAEMHWVDCYWPAFRHVDFLRALRSYANRERRFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK85</accession>
    <name>A0A7K2ZK85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycine betaine/L-proline transporter ProP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proP</name>
        <name evidence="8" type="ORF">GT040_26695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001249">
        <property type="protein sequence ID" value="MYW32762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018512391.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001249.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="49"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="498" mass="53556" checksum="0890856384A99478" modified="2021-04-07" version="1">MAAPDPHQAADPQAVKRHPTLFRAVRKRKNPKLRRTDITVTDDAAVKRAVKAASLGNAMEWFDFGIYSYLAVTIGHVFFPSGNETTQLLSSFATFAVAFLVRPLGGMFFGPMGDKVGRKKVLALTMILMAVGTFAIGLIPSHETIGVWAAVLLIFFRMLQGFSTGGEYGGASTFIAEYAPDKRRGFFGSFLEFGTLAGYVGAAGLVTALYALLNDAQMEAWGWRIPFLVAGPLGLVGLYLRLRLDETPAFQKLEGGTAHASEAADGVESTAKGDLAKIFRQYWPTLILCICLVGAYNITDYMLLSYMPTYLSDELGYSETHGLLILLAVMVFLMAIISQVGKLSDRFGRKPLLMTGMLGFLFLSLPAFLLIRIDGILPITVGMLMLGLSLVCMLGTMSAALPALFPTNVRYGSLSVGYNLSASIFGGTTPLVITALISWTGSNLMPAYYAMAAALIGVIAVACMKETAQQPLIGSPPSVETDEEAAELVQAQAPEPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKN1</accession>
    <name>A0A7K2ZKN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_27340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001273">
        <property type="protein sequence ID" value="MYW32888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="4">
        <location>
            <begin position="84"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="413" mass="43192" checksum="37AF4EC34AF56C55" modified="2021-04-07" version="1">MTAMDEQEQRRRRLAAWRGSHRVLARRSTDGTVAEGLAALAAAIGAGSGAEAGIGDGSGAGSGAGSDTGAGSGVVHDPDDAVDVYGGGVVADLERRVAGLLGTEAAAFFPTGTMAQQVALRCWAGRTGNATVALHPLAHPELHEEGSLGAVSGLRTVHLTSAARMPSAEEVRDHPEPFGTLMLELPLRDAGFVLPTWDELEAVVAAARERDAVVHLDGARLWECGPHFGRGLQEIAALADSVYVSFYKSLDGLSGAVLAGSDVLVEEARVWRHRYGGQLFQQYPAALSALIGLDRELPRLPSYVAHAKVVASAMAEGFAAAGVPWFRVHPEPPHTHQFQVWLPYDAEALDEASLRQAEETGVTLFRRWGAGAAGAAGLPPGVSVTEVTVAGAGLEWSAEDVREAVGVFVGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL45</accession>
    <name>A0A7K2ZL45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001311">
        <property type="protein sequence ID" value="MYW33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="12996" checksum="22FBF1DBA2D9E995" modified="2021-04-07" version="1">MTSMSREQQVPKVFVQVADVATIAILQQRDLGQEQLEKTQLQRALSSRIVIEQAKHPRRTLERHPPTPRTKPCAPTHGRTSCASPNAHATSSTRPWTPTAFPTPDLPGRRYRTGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLA1</accession>
    <name>A0A7K2ZLA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GT040_28600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001328">
        <property type="protein sequence ID" value="MYW33125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="425"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW33125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="547" mass="57915" checksum="48A979AF25E3A50C" modified="2021-04-07" version="1">MNAPPLSDRGPRRFGWPQRVFSQVLLMQLAIITGVTVLVTGLFLAPLSAQLDDEAMRRALAIAQSTAAQPGIAEDLRTTEPSALGPVQSAAEEIRRATGAEYVVVMDRRGVRWSHPEADRIGEVVSTDPSDALRGREVMEIDSGTLGRSARGKVPLRGPRDEVVGAVSVGIEYDSVRARLLGAIPGLLAYAGTALAVGALAAYLISRRLQRQTHDLAFSDISALLTEREAMLHSIREGVVALDGTGRIRLLNDEAQRLLGLGPEAAGRPLEEVLAPGRTVDVLAGRVVGDDLLAVQGSRVLLANRMETDDGGAVVTLRDRTELEHLGRELDSTTGLIDALRAQDHEHANRLHTLLGLLELEMHEDAMEFVTEVVGVHRATAEQVTEKVRDPLLAALLVGKATVAAERGVSLRLAPGTLLPDRVVDPRGLVTVVGNLVDNAMDAAAGSQDGRIEVGLRAEGRTVELRVRDSGPGIVPERYASIFTEGWSTKDLPAHGKRGLGLPLVRRLAERQGGSVTVSGADGGGAVFTVVLPEALGAASPTTGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLL5</accession>
    <name>A0A7K2ZLL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_28670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001333">
        <property type="protein sequence ID" value="MYW33139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="16"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="498" mass="51871" checksum="4F1F2510D3F0AD66" modified="2021-04-07" version="1">MSAKQAPPLDRALVMLGAVQMVGSFAALLDATIVTVALDATSREFGASEGSIAWVSTSYLLTMALVTPLVGWAVDRFGARRMWLFAISTFLVGSVLCALAWSVGSLVAFRVVQGIGGGLVLPLNLIILGRAAGPERFGRIMSLVAIPGQLAPILGPVAGGLLISGLGWRWIFFINIPLCLLALALSARTLPRGEQRGEAPLDRRGLLLLPPGLVLLVYGFSRIAEQGNGPGGTPVTVGCVILGAAAVTAFVVHARRTEDALIDLRLFSVKTFRASAVMTFLHGVAVYGPLLLLPLFFARVLGHDADSVGWLLAPQGIGSLIGITVAGSLADRYGPRPLVLASTVLTLAATLPFTQLASGLDTWALSGSLVVRGFGVGLLGVAIATASYRDVPRARISRATSTISVVQRVGASFGTAMVALLLAVQLSGISRQDPDPAGAQAAAYGNTFWWAVAFTVLALVPAAMLPRFKRDRPNADDPPQDDLPENGSPGTDTSAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLU0</accession>
    <name>A0A7K2ZLU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_29460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001363">
        <property type="protein sequence ID" value="MYW33280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="250" mass="25315" checksum="A1436EFEDC1E3B60" modified="2021-04-07" version="1" fragment="single">MSLVAKDAGADRLADAVRQVNAVRGRGRRRSVTVATALLLAVVTVFGLSLSVGDMVMPIGKVVETLLGGGDGGSRFVVLELRLPRALLAVLVGAAFGLSGGVFQTVLRNPLASPDLIGISAGASAVAVTAALLFQVSGLALSASALAGAVAAGAAIYLLAWRQGVAGQRLVLVGIGVGMGLSSVVWYVMARSDVTDAQEAFRWLAGSLNGRSWGQFWPILGALALLVPLTAVAAHALRPLQLGDDAAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLZ0</accession>
    <name>A0A7K2ZLZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001375">
        <property type="protein sequence ID" value="MYW33328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045999">
        <property type="entry name" value="DUF5955"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19380">
        <property type="entry name" value="DUF5955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="104" mass="11105" checksum="511930D2DE26BF5C" modified="2021-04-07" version="1">MLRSVGQKRVTGSGEDPRVAELRIAVSRLRRELASLSLEFPDRPIADEELAALDAMAVGEVPEIPRMRSSLLLLAGSIGSVSALAAALRDVRNAVDLFGEPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLZ4</accession>
    <name>A0A7K2ZLZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001387">
        <property type="protein sequence ID" value="MYW33385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029877346" evidence="1">
        <location>
            <begin position="36"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="392" mass="41884" checksum="84E4D3E76D792A09" modified="2021-04-07" version="1">MRRARPRPRIRANSRAVAALALSTAALTALTACGAAPEEKVETGANGVKSTEATSAADFGGLEKLVAAAEKEGELNVIALPPDWANYGEIIKSFQAKYKVKIKSENPDGSSSDEIAAVKSRKGQKRAPDVLDLGIAFARSGAAENLFAPYKVATWDKIPDSQKDADGRWYNDYGGYVSIGCDAARIKTCPETFADLLKPEYKGKVALNGNPTKSGSAFGGVYAASLADKGSFGDIQPGIDFFGKLKKSGNFIPVESTPATVEKGETPISIDWDYLNAGYADQFKGKGVDWKVSVPSDGVYAQFYSQAINKDAPHPAAARLWMEYLYSAEGQNLWLKGYARPVLLPAMTEDGTADKAFVAKLPAVEGTPTFPSSEELDKANATLSENWDKAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMC4</accession>
    <name>A0A7K2ZMC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001409">
        <property type="protein sequence ID" value="MYW33501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="218" mass="23453" checksum="B629B886A7E160AE" modified="2021-04-07" version="1">MTRAETKERNRRALLDAAFHVVSRDGHRARLDEIAERAGLTTGAVYSLFGSKSGLLGALVTDYLQPHYEEIEQAIPADADLLGAVDAFARYYRRTCDAADAPADQSLQFTLLGMALHDAEVGPRLAASVRAEEGRLIALFTGRRHEGAVVTEGQAHRLTTALRAVFIGLSQGVLLGLALGADEQFFADTARALVSGATLLEDLEPVSVARQPDSRVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMN5</accession>
    <name>A0A7K2ZMN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="262" mass="28595" checksum="DE657EEEA9947E34" modified="2021-04-07" version="1">MNALDYVDDQLSSVLKCWHVAPGGRPGTVSLSGRQYFADGDGIRVLIRVAGEEALASDGGVMAARLTDAGVDITSSTRAGTAWREILAQFELRELDGRIVGRRPLKQAEQLASDIASAMLTTDGLRWLALPERESKLTKQLYDFLRAGQFPFTRRPTISLPRGSKVKPTARVTTPKREVLIQAVAGGEQGIEHALSLVQRIDRANYGFDQRLVLLKGVPEEWPADHLDLLAEHTPVGFSDRMDQVQGFLGKGKALPSPVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMT0</accession>
    <name>A0A7K2ZMT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">msrA</name>
        <name evidence="7" type="ORF">GT040_31425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001438">
        <property type="protein sequence ID" value="MYW33657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="6">
        <location>
            <begin position="50"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="221" mass="24149" checksum="A7AC51AD1A5AE323" modified="2021-04-07" version="1">MFLNRRTPELPTPEQALRGRPVPEFTVPSRHTVLGNPLVGPYPDGLEVADFALGCFWGAERKFWQTEGVWTTLVGYQGGYTENPTYEEACSGLTGHTEAVRVVFDPAVVTYEELLKLFWESHNPTQGFRQGNDVGTQYRSAVYTHSPAQAAAADASREAYQKVLTASGHKEITTEILPAEGRPFWPAEAYHQQYLDKNPGGYCGIGGTGVSCPIGVAPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNI6</accession>
    <name>A0A7K2ZNI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_32865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001499">
        <property type="protein sequence ID" value="MYW33933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="191" mass="20000" checksum="A2EEAC0830152CE2" modified="2021-04-07" version="1">MGVSLAKGGNVSLTKEAPGLTAILVGLGWDVRTTTGADYDLDASALLCDESGKVLSNDHFVFYNNLKSPDGSVEHTGDNLTGEGEGDDEIVKVDLSAVPGTVAKIVFPVSIHEAEGRGQSFGQVRNAYIRVVNQAGGAEIARYDLSEDASTETAMVFGELYRHGAEWKFRAVGQGYASGLSGIVADFGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNL0</accession>
    <name>A0A7K2ZNL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_32835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001498">
        <property type="protein sequence ID" value="MYW33927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029837955" evidence="2">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="90"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17850" checksum="E8FDF5EDE35F42CD" modified="2021-04-07" version="1">MSPLSRPSRLRRIGLCVATGALAAVTAAAPALAADPHPVDHRGEAHTSAPASDELSASALQREYEAQQKEARQEAQTQNQAKPQAPKKTYKGRVIASPYLLLRDKPTRSSKVVGSVKYGTVVNIFCKTTGDNVDGNNRWYLLTDGTWAWGSARYIENIGAAPRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPD1</accession>
    <name>A0A7K2ZPD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4097 family beta strand repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_34330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001567">
        <property type="protein sequence ID" value="MYW34216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="131"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="266" mass="27551" checksum="59EF1183C18A0B0E" modified="2021-04-07" version="1">MDIRTSAPTRKRGGVPGRVIAVGGGVALLALALTGCGGADVEDAPVERKSFALQGKTLTVDAEDSTVTLVPADVDEVEVERQVDGWVVLGSGPDPVWKMENDTLTLRVKCDAMINNCAARHEVKVPRGVTVRADADNGEITATGFDAPLRLSADNGDIVVRDSGGALDLKSDNGSVLAERIGTKSVVARADNGEIRLGFSGVPDLVDTVSDNGSIVIDLPQGGEKYAVNASADNGEVAIGVPRSESSAHVVKARSDNGEVKVRTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPD5</accession>
    <name>A0A7K2ZPD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001560">
        <property type="protein sequence ID" value="MYW34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="128"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="311"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="553" mass="58572" checksum="1CB1D76F97DB25CD" modified="2021-04-07" version="1">MGSPKAKTGTSTKERFDPADWGRPPYAVIVVDRAGTAVRTEGETTLLPGVEQGVPLPDGLFWLAGATAAVADDAVHQGGSPRPAVEGRFAGRRFEAHPTRRADGEVVWWLVDHTARYAAEEALTAERERTRFLAEASNVLLSSLNSERCMAATARLAAGFLADAAVVVAPAAGRRLPVTRAVQGQDVTQDMIVADPSDVPGLAEALRGFPPVPSRWIDPTSLPEWLVPDGFGTTVGSVVVTPLPGHGVPAGALILLRADTRNGFSDTEEAFARLFAARAGAALSAARLYAEQHSITRTLMRDLLPPRLHRVHGVEFAGGYRPSSTHERVGGDFYDVHPGPTASDPSLVVLGDVCGKGLDAAVLTGKIRNTLQALMPMADDHERVLQLLNGALLNADNTRFATLVLASVLRTENQVRLRLTSAGHPAPLVVRGDGRVEEVPTRGSLVGALDQVSARTVETSLLPGDTCLLYTDGITEARGGPLGGELFGEERLKRALAECGGMPGDAVVEHIRMLTEQWLGDGGHDDVAVVAITAPRTTHLSAVDGHTRGRYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPF1</accession>
    <name>A0A7K2ZPF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_34015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001550">
        <property type="protein sequence ID" value="MYW34158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW34158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="52" mass="5225" checksum="2F1DA4CA48AD2E5C" modified="2021-04-07" version="1">ALTGALLVLVADFAAQHMLPSVQLPVGVVTSIIGAPYLLLLLARANRVGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPG0</accession>
    <name>A0A7K2ZPG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbamoyl phosphate synthase large subunit</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carB</name>
        <name evidence="2" type="ORF">GT040_34415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001581">
        <property type="protein sequence ID" value="MYW34232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="1">
        <location>
            <begin position="49"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="189" mass="19993" checksum="C76E9489C840311F" modified="2021-04-07" version="1" fragment="single">VMPWSRFRDIHGRGVDTVLGPEMRSTGEVMGIDSVFGTAYAKSQAGAYGPLPTSGRAFISVANRDKRSMIFPARELVAHGFELMATSGTAEVLKRNGINATIVRKQSEGEGPNGEKTIVQLIHDGQVDLIVNTPYGTGGRLDGYEIRTAAVARSVPCLTTVQALAAAVQGIDALNGGDVGVRSLQEHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPP8</accession>
    <name>A0A7K2ZPP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_34600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001586">
        <property type="protein sequence ID" value="MYW34268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="522" mass="59800" checksum="13225D2724F8C1BA" modified="2021-04-07" version="1">MNSQQIDAEHHRLDINVTNFQDRRQVPNGTWRIVPVIDDERLPEATFDLKAADRLDADSRTFLYDQNRSVYVIAFGISDDEDHPAFLMRTYQLFRGAGAKKPAKKKPIGKRIALKVVPRARRRKLANKFYRTARRLNPPKGNRILFASEMRTGLGGNLARVHDRMIERGLDKKYTFNHSFRVPATANKWSTLRLIYRLATSDTVLMDDYFGLLANLNIAPDTKIIQLWHAGSGFKAVGYSRFGKYGSPKLSNAHRKYTYVITGSKHLVPVYAEAFGIEESAVVPTGLPRIDTFLNEDHSRKVKDDFFASYPHLKGKKIVLFAPTFRGKSIGDAHYDYDRIDFEKLHEVCGDKYVVLFRMHHFISEEPPIPAEYADRLINFAEFPDTNDLLHVTDVLVTDYSSVIYEYTLLDKPILFYAYDKDTYSVVRGFHRDYDAVAPGKVCVTFDELLKSLQDEDFDLSKVEEFRRDNFDYVDTNSADRVIDWLVVGDHGNETGGFQPWLAPVPDDTAVGDQPLSDQSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ05</accession>
    <name>A0A7K2ZQ05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FdhF/YdeP family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_35440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001623">
        <property type="protein sequence ID" value="MYW34430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="5">
        <location>
            <begin position="120"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="6">
        <location>
            <begin position="643"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="764" mass="82724" checksum="81AE25525C5AA2EB" modified="2021-04-07" version="1">MASKPPAGDPVQDAPQVGTAPHAAAGLPAVAHSLRIAQQQMGVRRTARTLLKVNQKDGFDCPGCAWPEGDKRHTAEFCENGAKAVAEEATLRRVTPDFFAAHPVADLAERSGYWLGQQGRITQPVYLPEGADRYEAITWERAFAIIAEELTALDSPDEALFYTSGRTSNEAAFLFQLFAREFGTNNLPDCSNMCHESSGSALGETIGVGKGSVSLEDIHQADLIIVAGQNPGTNHPRMLSALEKAKNAGAKIISVNPLPEAGMERFKNPQTPHGMLKGTPLNDLFLQIRIGGDQALFRLLNKLILATEGAVDTAFVTEHTHGYQEFAQAAEAADWDETLTATGLTRAEIEQALALVLASERTIVCWAMGLTQHKHSVPTIREIVNFLLLRGNIGRPGAGVCPVRGHSNVQGDRTMGIFERPAPAFLDALDKEFGITSPRHHGYDVVRSIQALRDGEAKVFFAMGGNFVAATPDTAVTEAAMRRARLTVHVSTKLNRSHAVTGTRALILPTLGRTDKDVQAGGKQFVTVEDSMGMVHASRGNLTPASPHLLSEPAIVARLARAVLGADSRTPWEEFERDYATIRDRISRVVAGFEDFNTRLATHPGGFALPHAPRDERRFPTATGRANFTAAPVEFPELPAGRLLLQTLRSHDQYNTTIYGLDDRYRGIKGGRRIVMVNPDDAAALGLTDGAYTDLVSEWKDGVERRAEGFRVVHYPTARGCAAAYYPETNVLVPLGSTADTSNTPASKSVVIRFEEPRSTPGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ32</accession>
    <name>A0A7K2ZQ32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001622">
        <property type="protein sequence ID" value="MYW34427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="166" mass="17334" checksum="58F6B364995727FC" modified="2021-04-07" version="1">MAAGPPLGTPAPDFTLPGGVLSGPSVPGDTFERGDYTLSTARGRALVLAFYPGDNTSVCTKQLCSYSSGMETFEGLDAEVWGISPQGVDSHESFARTYGLRMPLLADEGREIAKAYGVAAPGIGVRRAVFLIGPDGVLRWKHVALLGATFQSLSTLADQLSGIKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ70</accession>
    <name>A0A7K2ZQ70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysE family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_35885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001631">
        <property type="protein sequence ID" value="MYW34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="20643" checksum="E9F8E454857CB6ED" modified="2021-04-07" version="1">MTNALTAAAAGFGTGLSLIVAIGAQNALVLRQGVRREAVSAVVVICALSDAVLIALGVAGVGAVVVSWPSALTVVSLLGGVFLIVYGLLAARRAFRPSALHAQDAPSGAKRGVVLACLAMTWLNPHVYLDTVFLLGSVAADRGPLRWVFGLGAILASVCWFAALGFGARLLSGVLARPSSWRVLDGLVAAMMIGLGARLALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ86</accession>
    <name>A0A7K2ZQ86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2637 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_35600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001625">
        <property type="protein sequence ID" value="MYW34458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="477" mass="51013" checksum="54F240251662A982" modified="2021-04-07" version="1">MPTLYTVAALAGGLVGAIGFAASYSTLEAAALRWGFGPGLASAFPIGIDASIIAFLALDLVLIHRRTPWPLLRLFAHAMTVVTIVLNASAQKGGLTLSAKTLSHAVMPILFVIGVEAGRRLVVRAARLAEGQETEGVPGHRWLLAPWPTWLIWRRMKLWKLRSYTEAVAQEKAVTIYAMRLEQKHGKRWRKVAKPDELLPLSLAPYGLTIEEALMVPEKERLAEAERARAAKAREDQEAAEELARETEAKNQRTAAQIAAMEADAKVTEAATSIQARTATAEVNAGANVAAAEAAAKAKAEAVRQAAEVEAAAQESVSVRLARQKVAEEEKLAADAEKEAADAKRAAVDAKRAADDAARTAADARLRTAEINARAVAKEKETAEAVRATADVKRAAADARRAAADAENAALEAEALLKLQPTERTARYVARIVLNEYGGDVERMSVESVMEVLGTSHGTASKRRQEAADLIGSGYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQB0</accession>
    <name>A0A7K2ZQB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_36025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001636">
        <property type="protein sequence ID" value="MYW34540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="220" mass="23315" checksum="16C26038A8ACD6D4" modified="2021-04-07" version="1">MTENSERTPERTITVVLVDDHPVVRDGLRGMFTAEPGFDVLGEAADGVDALAVVERHDPDVVLMDLRMPGGGGVAAIAELTRRGVRSQVLVLTTYDTDSDTLPAIEAGATGYLLKDAPREELFAAVRAAADGRSVLSPAVASRLMTRVRTPTAPADATLSAREREVLVLVAKGTTNREIAAELFISEATVKTHLTHIFAKLGTKDRAAAVAVGYDRGILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQI9</accession>
    <name>A0A7K2ZQI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yajC</name>
        <name evidence="10" type="ORF">GT040_35960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001634">
        <property type="protein sequence ID" value="MYW34529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029527960" evidence="9">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="166" mass="17371" checksum="9B548B8E6BAFD6E0" modified="2021-04-07" version="1">MDILTLLPFIVLIGAMFLMTRSAKKKQAAAAQMRNDMQPGTGVRTIGGMYATVKEVHDDTVLLEVAPGVHAIYAKNAIGAVLDDAEYNRIVHGDDEELDADGTVVPDDASSLTGEPDADKADIAKIDLGKDEAADKDAETGTEDVAAKDVKDAKGDGKADGEAGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQK7</accession>
    <name>A0A7K2ZQK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_36580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001673">
        <property type="protein sequence ID" value="MYW34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="57"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="186" mass="20081" checksum="0E744C882AB17F45" modified="2021-04-07" version="1" fragment="single">ATVTGTTYTNTGLTAGTDYTYAVQARDTIDQLGPVSGSVSVRTTGGGGGEEPPPGDKINLGYFTNWGVYGRNYHVKNLVTSGTAAKITHINYAFGNVQNGKCTIGDSYADYDKAYTADQSVDGKADTWDQPLRGNFNQLRKLKAQYPHIKVLWSFGGWTWSGGFGQAVQNPTAFAQSCYDLVEDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR32</accession>
    <name>A0A7K2ZR32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trans-aconitate 2-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tam</name>
        <name evidence="3" type="ORF">GT040_36840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:14969"/>
            <dbReference type="ChEBI" id="CHEBI:15708"/>
            <dbReference type="ChEBI" id="CHEBI:57470"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.144"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Tam family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.144" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001680">
        <property type="protein sequence ID" value="MYW34699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00560">
        <property type="entry name" value="Tran_acon_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023506">
        <property type="entry name" value="Trans-aconitate_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="49"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="276" mass="30539" checksum="4F4B8A82EAE5B852" modified="2021-04-07" version="1">MPPTPPTPLTTEPTWDPQQYLRHADHRTRPFQDLLARIGDLPGHPAPRIADLGCGAGNVTALLADRWPQARITGYDTSPQMLAEAAAYARPPLLDFAEADAATWTPTETYGLIVSTSALQWIPGHTAYFPRWLDALAPGGTLAFQVPGNFTAPSHTLLAQLRDSDRWRPRLHGTGDRTASVLEPTDYLTRLRDLGCTADVWETTYLQTLHGDDAVLDWVKGTALRPVLTALADDPEARDAFLTEYRDLLREAYPAGPYGTVFPFRRIFAVARRGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR63</accession>
    <name>A0A7K2ZR63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_37605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001698">
        <property type="protein sequence ID" value="MYW34846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029711409" evidence="2">
        <location>
            <begin position="40"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="96"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="364" mass="40266" checksum="6208EADA859707B5" modified="2021-04-07" version="1">MSRTSKDTELARRLSRRNVLGVAAGATAATIIGTATAQAAGRDHAQGPGKGHGHGHDHGHGHGHGKGKPVLPPGRLGIQLYSLRDKISTLGFAPVFAELEKYGYDEIELAGYTQGSAGPITLAQLKRLAKDHGLNPIGSHVGYYDDNNPGAYTFAQNLEKVLDDAQALGLKHIGTASGPFRYGSTVDGWKRAAEDFNTYGAAARKRGMKFYQHNHAEEFSFATDKPKVRLYDVLLAETDPDLVYLELDIYWAYCAQFRFSKRADGTKAPLDPLKYVLKHPNRYPLFHVKDGVRDDTTRDGYRMSDVGDGDIDYKTFLSKVTNRTHHGRTYHHWQAEHDNPVESLAFARKSSEHLHSLREGRCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRI0</accession>
    <name>A0A7K2ZRI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TROVE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_38280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001734">
        <property type="protein sequence ID" value="MYW34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="PTHR14202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="SSF140864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TROVE" evidence="5">
        <location>
            <begin position="29"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="529" mass="57864" checksum="F18349B73EC692B9" modified="2021-04-07" version="1">MARFNQRVTQLRSTPWRPTSPVTTTGALAANHQGGTGRVRDARSELFLLAVANFVAQETFYEGGEERDTRFAALVRRLAVEDPAWTAGLLHWLRRDGRMRTASLVGGAEYVKARLDAGCTEGPANRQVIDSVLLRADEPGELLGYWTSRYGRALPKPVKRGIADAVRRLYSGRSLLKYDTASKGFRFGDVLNLVHAAPDPAKPWQGELFRYALDRRHRPESAVPPVGDRTLNAHRALMELPVAERRAVVTGPGGAERLAEAGMTWEALAGWLQGPMDAEAWEAVIPSMGTMALVRNLRNFDEAGVSDEVAAGAAERIRDPEAVAASRQFPFRYLAAHRHAPSLRWAYPLEQALGHSLSQVPALPGRTLVLVDRSGSMWSPLSDRSRLNRADAAAVFGAALALRAADADLVEFGTTSAPVAYRTGESVLRVLERFGNLGGTDTVRAVERHYRGHDRVLVVTDEQASYTYRGDATRSVPDTVPVYTWNLAGYRLGHAPSGDGNRHTFGGLSDAAFRMVPLLEAGVSADWPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRN1</accession>
    <name>A0A7K2ZRN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_38445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001743">
        <property type="protein sequence ID" value="MYW35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="18294" checksum="EDA0BA28D5AF975D" modified="2021-04-07" version="1">DVDVPAGGRGRPSGGTWTAPEPKDEPTEEPKDSCPPPASEPESESLFDESDAPIQLTAKQQQDADFDAWYALYPRKEARGKARLAFAAAVKKGVKPDTLIAALHKHRDHWAACKTETKFIPHPTTWLNSERYDDELTTPANRWNGPAPTAPSTMTDEEKKRALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRR1</accession>
    <name>A0A7K2ZRR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenazine biosynthesis protein PhzF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_38660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001759">
        <property type="protein sequence ID" value="MYW35045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="135" mass="14354" checksum="0AB092AD4163B1E1" modified="2021-04-07" version="1">LDPALPPRIAYAGARHLVLAAATRERLADLAYDFARLEALMRRLDLTTLQLVWREAPEVFHVRDPFPVGGVVEDPATGAAAAAFGAYVRELGLVPATAVLTLHQGVDMGRPGTLTVELRAGDDRVRVSGTGTSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS60</accession>
    <name>A0A7K2ZS60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hisB</name>
        <name evidence="7" type="ORF">GT040_29940</name>
        <name evidence="8" type="ORF">GT040_39470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="WWKE01001386">
        <property type="protein sequence ID" value="MYW33373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001789">
        <property type="protein sequence ID" value="MYW35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030586622.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="66957034"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW35196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="198" mass="21711" checksum="0DB51D00AF82ABC9" modified="2021-04-07" version="1">MSPRVGRVERTTKETSVLVEINLDGTGKVDVATGVGFYDHMLDQLGRHGLFDLTVKTEGDLHIDSHHTIEDTALALGAAFRQALGDKVGIYRFGNCTVPLDESLAQVTVDLSGRPYLVHTEPEKMAPMIGEYDTTMTRHILESFVAQAQIALHVHVPYGRNAHHIVECQFKALARALRYACEHDPRAAGILPSTKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS77</accession>
    <name>A0A7K2ZS77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molecular chaperone Hsp90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_39665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001805">
        <property type="protein sequence ID" value="MYW35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="26156" checksum="9E9AB734231264D1" modified="2021-04-07" version="1" fragment="single">GGVRWSLAEARELARNAAVGSPGLGDELRRRDGHVPLLRLPLPAEGTAPDGYDTVVVLPLRDGTAEDLAARLLAAVDDALLLTLPGLAEVVIETPDGVRTLSRSAHGPYTHIDDTAHGLNRWRTVFHHGPVEPALLADRPVEERLRPHWSVTWAVPVDGSGAPLKPRTTPVVHAPTPTDEPLGIPALLIASLPLDTARRHPAPGPLTDFLVERAADAYAELLGAWQPVSTGTIDLVPGPLGKGGLDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSD3</accession>
    <name>A0A7K2ZSD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_39995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001830">
        <property type="protein sequence ID" value="MYW35291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="65" mass="6789" checksum="7E759D7F2ADCD336" modified="2021-04-07" version="1">MCGALPHCRIVSGSNRPDRASENRSCSGTGPSRGRGVPGPRLRALTLSGCPRMLQVALRACAPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSI6</accession>
    <name>A0A7K2ZSI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_40065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001832">
        <property type="protein sequence ID" value="MYW35305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="355" mass="37280" checksum="3D87BF8C14D0EE69" modified="2021-04-07" version="1">MTARLADIATQAGVSEATVSRVLNGKPGVAATTRESVLAALDVLGYERPVRLRRRSAGLVGLITPELENPIFPALAQVIGQALTRQGYTPVLATQTPGGSTEDELTEMLVDRGVSGIIFVSGLHADTSADMQRYEQLRGQGVPFVLVNGFSAKVQAPFISPDDRAAMRLAVTHLVALGHTRIGLAVGPKRFVPVLRKIEGFHATMQEQLGLTPDAVEELIQHSLYTLEGGQAAASALMERGCTAVVCASDMMALGAIRAARRLSKEVPRDLSVVGYDDSPLIAFTDPPLTTIRQPVTAMGQAAVRTLLEEIGGTPAPHSEFVFMPELVVRGTTASGPGTGNGPGPVGGTGSHPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSJ3</accession>
    <name>A0A7K2ZSJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c biogenesis protein ResB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_39865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001828">
        <property type="protein sequence ID" value="MYW35268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="8">
        <location>
            <begin position="79"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW35268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="613" mass="66056" checksum="965C603026205BF7" modified="2021-04-07" version="1">MSKANNSTDTGAGTEETDTGTRTAEAAAEREQERVDHAAGERLSTAPREERPESESGTGVPAMGVVGWIRWFWRQLTSMRVALILLFLLSLGAIPGSLIPQTSVDDLKVQNFKDQHTTLSPIYEKFQLFDVYSSVWFSAIYILLFVSLIGCIVPRTGQFVGQLRSRPPGAPKRLTRLPAYTTWRTEAEPEAVREAALGVLGKRRFRTHPVGDAVAAEKGYLREAGNLIFHIALIVMLVAFAAGQLFKSEGGKLVVEGDGFANTLTQYDDFKSGSLYDSDSLAPFSFVLDDFVGTYEESGPQRGTPRTFEARVKYTEGADGPERKSVIRVNEPLVVDGTKVYLIAHGYAPVVTVRDGKGKVVSRNSVPLLPIDNNITSTGAIKVMDGYRDKNGVKTQLGFKAFFVPTFAGHGKGQMFSQFPGAEFPVLALSAYRGSLGVDSGLPQNVYQLDTSKMKEFKNEDGELLKKMLRPGEKLDLADGEGSITFDGIEEWASFQISQQPGNGWALGGAVAAIAGLAGSLFIQRRRVWVRAVRGEDGVTVVEMAGLGRSESAKLPEELGDLAAALITTAPVAPEKPDAPESPDAPGPSDDATNEAGSRPVHPADAPAEGAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSQ7</accession>
    <name>A0A7K2ZSQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001848">
        <property type="protein sequence ID" value="MYW35424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="173" mass="18484" checksum="351020B7E0C8677E" modified="2021-04-07" version="1" fragment="single">MTSMLDAVVVGAGPNGLTAAAELARRGFAVEVHEAHDTVGGGARTEELTLPGFRHDPCSAVHPLGIGSPAFRAMPLARHGLQWLHPEVDLAHPFPDGTAAALTRSVGESAMTLGPADAGAYRRLVAPFTGRWDTLAADFLRTPWDGLPRDPYRLARFGLLGVQPATWVSRRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5U5</accession>
    <name>A0A7K2Z5U5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF417 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000001">
        <property type="protein sequence ID" value="MYW27714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007339">
        <property type="entry name" value="RclC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04224">
        <property type="entry name" value="DUF417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="16042" checksum="3E7BF0493F4CC0FC" modified="2021-04-07" version="1">MADLAGLVDAHALALLRATVGIVFVGFGVLKLFPSASPAEQLAVDAATKMTLGLVPETVLLLSLAALETAIGIGLIVGRRLLRPALVAFFLHMGGVFSTLVLLPDAMWQPHSPAPTMEGQYVVKNVVLVAVCLVVAANEWARHSRPRRRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z639</accession>
    <name>A0A7K2Z639_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000016">
        <property type="protein sequence ID" value="MYW27798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="130" mass="15067" checksum="35172ECF4EA3E263" modified="2021-04-07" version="1">MHWIWWILILFWTGGFAWAADTARTALRNRHERKLELLEAAKQERLALEAAHKSPEPVCGCTHHLAKHDKRGRCHEQVEVPTAWDENKKPLRYEAGQCNCQQYVGPQPLSQVYAEELTDRWPTDPPTTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z640</accession>
    <name>A0A7K2Z640_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_00590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000017">
        <property type="protein sequence ID" value="MYW27804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW27804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="340" mass="35632" checksum="5E8ABBCAC2715A2B" modified="2021-04-07" version="1">MTSPPTRPAIRAEGLTKRFGRKQALAGVDLEAAPGTVLGVLGPNGAGKTTTVRVLSTLLRPDSGRAWMAGHDVLADPEAVRRDLGLSGQYAAVDEKLTGRENLYLVARLYGFGRHAARRRAGQLLSGFDLEDAADLPSGTYSGGMRRRLDLAGALVARPAVVVLDEPTTGLDPRGRADTWQAVRDLVAEGTTVLLTTQYLEEADQLADTIVVIESGAVVARGSAAELKARVGGERLSLSVPEPRHQVTAAEILATLGEHLPELDPRTGRLTVTTDHGAQSLEYALGCLRLAGIAVRDVELSPPTLDDVFLSLTGRPPAPVGEAARPPASSGIATVGGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6H4</accession>
    <name>A0A7K2Z6H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_01325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000059">
        <property type="protein sequence ID" value="MYW27947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW27947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="226" mass="24417" checksum="4BF7A658767F0A90" modified="2021-04-07" version="1">MAKPDAKSGTTSDAATPRERYRAQVRTEIKEHAWEQIATAGASALSLNAIAKRMGVSGPALYRYFAGRDELITELIRDGYRSLADTLRTAAAGGAGLSGLAHALRGWALEDPHRYFLLYGTPVPGYHAPDDTTAISSEIMATLLDACAALTREVPAAPFAAHLAEHRDWAGDHPAPPAALHLAMSFWTRMHGVLSLELAGHFTGMRFDPARLFAAELDDLLRQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6M1</accession>
    <name>A0A7K2Z6M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_01490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000064">
        <property type="protein sequence ID" value="MYW27978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041273">
        <property type="entry name" value="DUF5596"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041644">
        <property type="entry name" value="GNAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18164">
        <property type="entry name" value="GNAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18082">
        <property type="entry name" value="NAT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAT_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GNAT_C" evidence="2">
        <location>
            <begin position="143"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="312" mass="33971" checksum="7B4FAE6E84CED655" modified="2021-04-07" version="1">PDPVLPSTADLARRLDLLAVPGQDRKPVYEGLAAATEDPAAREALVRCHQRLFADGPGTPTAPLAWPDAPAGLGEAGRYFYVHLLVLALPAALERQRVLGIPDDVVTATFADLGAKLRSYRLAHGTGGFDRQRWMVRHFRGTLHRLGRLQFERGILDAEGCGGDAEAAGGPAHGDPVLQVHIPEDGPLSRAGCDASFAAAGPFHDRHFPETRFRHATCSSWLLDRQWADHLPESSNILAFQRRFQPFGARHVGDDDVLEFVFHVPPGRADLDRLPQKTTLHRAAVGHLRAGGHWRMTHGWTSVPGRGTGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6R3</accession>
    <name>A0A7K2Z6R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_01795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000076">
        <property type="protein sequence ID" value="MYW28035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="315" mass="31667" checksum="F2FA53FF5F7638B1" modified="2021-04-07" version="1">MLLAVLLSLAVGARSIPPGEVFDALLHGGDSDAAEVIRSMRVPRTLIGLMVGAALALAGTVLQGITRNPIADPGILGISQGASVAVVMAIAFAGVHTLTGYVWFAFAGAAVASVAVYAIASRGRGGATPVKLALGGAAINALLVSVTMGVLTTKASALDEFRFWQVGSIAGREADVVQQVWPFLLVGVVLVLSVARGLDALALGEDVAKGLGQNVAAVRITGGIGATVLTGVGVAAAGPIAFIGLAVPHIARAVVGNDHRWVLPMAALIGPVMLLVSDVVGRIVFPPSEVPAGVMTALIGVPFLVALVRRKAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7B3</accession>
    <name>A0A7K2Z7B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000120">
        <property type="protein sequence ID" value="MYW28231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515259.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000120.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="68" mass="7074" checksum="2490FC2A9A40BD2F" modified="2021-04-07" version="1">MADTATRTMIRTQGRKAYASFGARPSGTRHPLVATAMVLPLAALLVVAFGGWDAVVTQASSVAVMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7D1</accession>
    <name>A0A7K2Z7D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000133">
        <property type="protein sequence ID" value="MYW28260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mg_chelatase_C" evidence="1">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="13878" checksum="EFF602DB6B1954AB" modified="2021-04-07" version="1">RVEVEPVDRADLLEQGGRGESTAVVAARVREARARAAERLAGTPWTTNSEVPGHELRTRLLAAPGALAAAERDLERGILTARGLDRVLRVAWTVADLRGAPRPEDRDIAVALELRTGIQRGAPMEMGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Q5</accession>
    <name>A0A7K2Z7Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_03630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000150">
        <property type="protein sequence ID" value="MYW28384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="329" mass="34918" checksum="724B99EEEF8B492C" modified="2021-04-07" version="1">MGQGKPGIRPQKPARQSARQPSLSQLRAFAAVAEHLHFRDAAAAIGMSQPALSGAVSTLEEALGVQLIERTTRKVLLSPAGERLAARTGVVLEAVAALMEEAEAARAPFTGVLRLGVIPTVAPYLLPTVLRLVHDRYPDLDLQVHEEQTSSLLEGLAAGRLDLLLLAVPLGVPGVSEIPLFDEDFVLVMEQDHWLGGRADIPRDALRELPLLLLDEGHCLRDQALDICREAGRTEGAPVTTTAAGLSTLVQLVAGGLGVTLLPRTAVTVETARNDALATGYFAHPAPTRRVALAMRTGSARGGEFEEFAAALRGAMEPLPVRVVDEPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7S1</accession>
    <name>A0A7K2Z7S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000149">
        <property type="protein sequence ID" value="MYW28372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7033" checksum="81FB4B74C5B8F00D" modified="2021-04-07" version="1">MNHQSIVTAFRKSSHSSGGQGSECLEVAHTADGGRAVRGSKNPSGGLQFYGPGHWAAFIDGVKAGTFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7U9</accession>
    <name>A0A7K2Z7U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000150">
        <property type="protein sequence ID" value="MYW28383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="800" mass="84632" checksum="9B76250A73D3946E" modified="2021-04-07" version="1">MTLLDSRDAPAAERDRPKPPARGAATLRDLGLGIRFAAAGGREGWIRTLLTAVGVGLGVALLLLASSVPHMLDQRNGRDQARKEAPVSGAPGANAPKSDTSVVVADSGTEYHSQTVAGYLVRADGTAPARPPGVDRFPGADEMVVSPALKELLAAPGNDLLRERLPYEITGTIGDIGLRSPNELRYYAGNDTLTIASGGHRIAGYGDTREAAPLSPLLVMLTVMVCVVLLVPVAIFIATAVRFGGERRDRRLAALRLVGADIRTTRRIAAGEALFGAVLGLLAGLVFFVAGRQFAGSVEIWDVTAFPADLVPDPLLAALITVAVPLTAVLVTLVAMRSVAIEPLGVVRRGRDQGRRLWWRLLMPVAGLVVLASTGRVSTYEYAPFNPYFIATGAVLVLVGLALLLPWLVEACVSRLRGGPVPWQLATRRLQLSSGAASRAVSGVTVAVAGAVALQMMFAAMNADFNRMTGQDPTRAQFAGYSENVTGEAATSAIAQFRATKGVEAVIGSVEAYASKPGVYADDDIPPTTSLTIGTCATLRELARIGACQDGDTFVVHPPGDQEMSDWIDETARKGEVVEIGSGSGKPVRWTLPADSLTVQGRTDPMGDPHHGIMATTGAIDAGTLPGAQITAQIRVDRSVPDVAEHVRNTAARIDPAMRFVTLDSVERDRQYESIQTGLKVGATVVLLLIAASMLVSQLEQLRERKRLLSVLVAFGTRRTTLSWSVLWQTAVPVVLGLVVAVAGGLGLGATLTWMIEKSVSDWWLFLPLTGAGAGLILLVTALSLPSLWRLMRPDGLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7X4</accession>
    <name>A0A7K2Z7X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000174">
        <property type="protein sequence ID" value="MYW28460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="176" mass="19882" checksum="7F750F90E797955B" modified="2021-04-07" version="1">MQWTNVSEQSVYQNRWFRVNLADVELPDGSHLDHYVIRLRPVAAATVVNASDEVLLLWRHRFITDSWGWELAAGVVEEGEDIAAAAAREMEEETGWRPGPLRPLLTVEPANGLTDARHHLYWAEEGQYTGPPQDAFESSRREWIPLKLIPDMIARGEVPAANMAAGLLMLHHLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z816</accession>
    <name>A0A7K2Z816_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000186">
        <property type="protein sequence ID" value="MYW28481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="82" mass="8980" checksum="1E2D53CC8CAEDF01" modified="2021-04-07" version="1" fragment="single">MGEDDTRLRAVVSLAQTMAAAYTPRESWRAAALGACEALGGSFAALSVWERDRGRLRVLVNAGQRAEGEEEFPEEEAYPVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z830</accession>
    <name>A0A7K2Z830_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GT040_04285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000195">
        <property type="protein sequence ID" value="MYW28509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029705426" description="Histidine kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="240"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW28509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="485" mass="50606" checksum="B1869A085B9818BA" modified="2021-04-07" version="1">MRWALVKVCLAVTAMVVIAFAVPLGLVIREMASDRAFSDAERQAAMIAPALSITTDREELTRAVLSTEPGDRGRLAVHVPAPEKAAGGAAGEALDIGTRRASPKDVATVRKAGRASITEATGGFALLQPTALSTGDIAVVEVFVPEGEVSNGVATAWLILAGVGVALIVGSVAVADRLGVRMVQPAQRLAGAAHDLGEGRLGTRVPEEGPTELRSAAVAFNSMADQVVQLLANERELAADLSHRLRTPLTVLRLNAASLGEGPAADQTRAAVEQLEHEVDTIIRTAREQRPQTQGIQTGAGAGCDASEVIRERMGFWSALAEDEGREVRLAGVDRTVRIPVARPELVAALDALLGNVFRHTPEGTAFAVDVHHSGDAVIVLVSDAGPGIADPEAALARGASKPGTVGSTGLGLDIVRRVAESTGGDLRIGRSVLGGTEVRIWIGLHGSNPDRGRRGHGRRVTRRFGRPRRKEPRTTAGPATSGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z874</accession>
    <name>A0A7K2Z874_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1290 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sbp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000201">
        <property type="protein sequence ID" value="MYW28557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003970459.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000201.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009709">
        <property type="entry name" value="DUF1290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06947">
        <property type="entry name" value="DUF1290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018579">
        <property type="entry name" value="Sbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="110" mass="11393" checksum="625A1338FE277E9C" modified="2021-04-07" version="1">MIAVLGLVVGVVVGLLVRPEVPAVVEPYLPIAVVAALDAVFGGLRAMLDGIFVDKVFVVSFLSNVVVAALIVFLGDKLGVGAQLSTGVVVVLGIRIFSNAAAIRRHVFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z878</accession>
    <name>A0A7K2Z878_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_04345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000197">
        <property type="protein sequence ID" value="MYW28518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="34"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="366" mass="39052" checksum="62309033175DA3A5" modified="2021-04-07" version="1">MSTTATPHPVPAQPSPPSSAARGAGGAPREHRFDIDLIRLTCSVGVIVSHTGAAFMDAAGRKASGGAGVYWTGLIADSLGRFAVPTFFAIAGWAVLVGAPPKDAARLRQRLVRILVPLAVWTAVYLVWGRWRGTNDGPIGDLALESLFASVRPAYHLWYLYAYVPVIMLLALVPMVKAGKRPWGLAAALLVVAAAPTLAGDLGRLTDWDVPRFGWNFGAYQVIYAVLGALLLAAPAAAFGRRRLPWVLLAGASLVVVTAYQHQVHYVIPNASVVIAVFTGAFVIALHRVRVPERIRPAVTLLVNATFGAYMVHILFEDVLTDAFVRPDLGWPAAAALFVAVSGAITALSFAVTLLWRRMGLARLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8B4</accession>
    <name>A0A7K2Z8B4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_04690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000206">
        <property type="protein sequence ID" value="MYW28581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="252" mass="27029" checksum="B8D826C079B9B8C7" modified="2021-04-07" version="1" fragment="single">MAATLAAETAALLHRGTVIPAHPLALTADRTLDERRQRALTRYYLEAGAGGIAVGVHTTQFAIREHGLFRRVLELAAQESGTVAAERPFLRVAGVAGPVRQAVQETATARELGYDAVLVSPAGLPHVTTEDLLDRSAAVGEILPVIGFYLQEAVGGRELPRAYWHALADQESTVAVKAAPFDRYRTLELVQGVADSARGQEVALYTGNDDNIVADLLTPYHVTTPAGPAVRRFVGGLLGHWAVWTRSAVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8P9</accession>
    <name>A0A7K2Z8P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_05180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000235">
        <property type="protein sequence ID" value="MYW28675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="15327" checksum="FCBBC2F444EC1ECE" modified="2021-04-07" version="1" fragment="single">TADRPHTSALSVPGVRVLVVAFLGIGAVFGGMQVSLTAFSQEIGHPGVNGLLYGIFAAGNMLAGIVCGAIAWKSSPQRRLVVGYMALTLMASGLWAVHSVPLLAGLGLLVGLCIAPALISGYTLVESLVPAGARTEAFTWLTGAVALGQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8T4</accession>
    <name>A0A7K2Z8T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_05635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000251">
        <property type="protein sequence ID" value="MYW28764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="385" mass="41453" checksum="E8393956A60595F6" modified="2021-04-07" version="1">MAGSTDFDLYRPAEEHDMLRETIRALAETKIAPFAAAVDEESRFPQEALDALVASDLHAVHVPEEYGGAGADALATVIVIEEVARACASSSLIPAVNKLGSLPVILSGSEELKAKYLGPLAKGDAMFSYALSEPDAGSDAAGMKTKAVRDGDFWVLDGVKRWITNAGVSEYYTVMAVTDPTKRSKGISAFVVEKSDEGVSFGAPEKKLGIKGSPTREVYLDNVRIPADRMIGEEGTGFATAMKTLDHTRITIAAQALGIAQGALDYAKGYVQERKQFGKPIADFQGIQFMLADMAMKLEAARQLTYSAAAKSERVDGDLTFFGAAAKCFASDVAMEVTTDAVQLLGGYGYTRDYPVERMMRDAKITQIYEGTNQVQRIVMARNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9L7</accession>
    <name>A0A7K2Z9L7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3145 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000305">
        <property type="protein sequence ID" value="MYW28992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="164" mass="18052" checksum="AB3238AEBB3386A0" modified="2021-04-07" version="1">MTTRGFLYVHSAPRALCPHVEWAVAGVLGVRVQLDWIRQPAAPGTWRSEFSWKGRAGTASQLASALRGWDLLRFEVTAEPCPTAEGERYSSTPGLGIFHAVTGMHGDILIPEDRLRAALARSTRGESDLEVEIASLLGKPWDDELESFRHAGEGAPVRWLHQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9N8</accession>
    <name>A0A7K2Z9N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_06910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000310">
        <property type="protein sequence ID" value="MYW29012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="33" mass="3398" checksum="10A91183D465533C" modified="2021-04-07" version="1">EGVAAWIAHCGRSVELGVRESTAVCEALQRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9T8</accession>
    <name>A0A7K2Z9T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_07475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000353">
        <property type="protein sequence ID" value="MYW29120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1431" mass="153450" checksum="4CAB842E35FBA972" modified="2021-04-07" version="1" fragment="single">MTGSALDAFSPATRSWFAGAFSAPTAAQEGAWRAIGEGSDVLVVAPTGSGKTLAAFLASLDRLASGPPPAEAKKRCRVLYVSPLKALAVDVERNLRSPLTGIRQESVRLGLPEPEVRVGIRSGDTPPAERRSLVTRPPDILITTPESLFLMLTSSARDALAGVETVILDEVHAVAGTKRGAHLALSLERLDELLPRPARRIGLSATVRPVDEVARFLSPQRKVEIVQPPSTKEFDLSVVVPVEDLGELGGSPATDGDAAQAEKPSIWPHVEERIADLVQSHRSTIVFANSRRLAERLCNRLNEIAYERATGTAFDPDNPDHPALDLPEAHAPAEVMAQSGAARGAPALLARAHHGSVSKEQRAQVEEDLKAGRLPAVVATSSLELGIDMGAVDLVVQVESPPSVASGLQRVGRAGHQVGAVSTGVVFPKYRGDLVQAAVVTERMRTGAIEALRIPSNPLDVLAQQLVAMVALDSWQADDLLALVRRAAPFASLPESAFTAVLDMLAGRYPSDAFAELRPRVVWDRVGGTVTGRPGAQRLAVTSGGTIPDRGLFGVFLAGADPRKGGGRVGELDEEMVYESRVGDVFTLGTTSWRIEDITRDRVLVSPAPGVPGRLPFWKGDQLGRPLELGRALGAFLREIGGLSEEDARLRLLAAGLDAWAADNILAYLDEQRRACGHVPDDRTILVERFRDELGDWRVVVHSPFGAQVHAPWALALSARLGERYGMDAQVMHADDGIVLRLPDADMMGLDLLDFDAPPAGDAANHGATAQPPSYDSEQPPVGATDVVFDQGEVQQIVTDQVGGSALFAARFRECAARALLLPRRSPGKRTPLWQQRQRASQLLQVASEFGSFPIVLEAVRECLQDVFDVPGLTELMGDLEARRVRLVEVTTQEPSPFARSLLFGYVAQFLYEGDSPLAERRAAALSLDSHLLAELLGQAELRELLDPEVLTELEQELQWLTEDRRIKDVEGVADLLRVLGPLTDAELAERGAEPSWAPELATTRRAIQVRIAGADHWAAIEDAGRLRDALGTALPVGVPEAFTEPVKDPLGDLLARFARTHGPFTAARAAERFGLGTAVTDGALQRLATSGRTVQGEFHPAGIGQEWCDATVLRRLRRRSLAALRQELEPVEPAALASFLPQWQHFGSHRLRGIDGLARAVEQLQGAPVPASALEKLILPSRVMGYTPAMLDELTTTGEVVWAGAGALPGKDGWLSLYPADSAPLLLPAPHPLELSALHESLLTTLSGGYGLFFRQIADQVRATTHPDASDQQLADALWELAWSGRLTNDTLAPLRSLLGSGRTAGSTAHRARRNVPRGRYGSLTAAARPASRTGPPTVSGRWSLLPPREPEPTHRAHALARTLLDRHGVVTRGAVQAEGVEGGFSATYRILAAFEDSGQARRGYVVEGLGAAQFAMDGAVDRVRAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA19</accession>
    <name>A0A7K2ZA19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000367">
        <property type="protein sequence ID" value="MYW29221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="213" mass="23764" checksum="ADB17BB065C15260" modified="2021-04-07" version="1">MAEGLRERKKRQARQHISDLATGLFLEHGFTAVTVAEIAELADVSVNTVYNYFPAKEDLFLDRMKGVTQRVARYVRARDKGESAAEAVLREARAAVVAVSPEFGLMDGFADFMRVIEEAPTLKARLWYLQQEVLQAVVETLREETGAAEDDPLPLLVGGQIAWIEHTLVGYVSQEMMKRRTAVDVARDALGVLDEIEDLLGDQVLNYARRGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA47</accession>
    <name>A0A7K2ZA47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_07930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000364">
        <property type="protein sequence ID" value="MYW29209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="7">
        <location>
            <begin position="36"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="9">
        <location>
            <begin position="565"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_DH" evidence="8">
        <location>
            <begin position="925"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1059"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW29209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1107" mass="115933" checksum="05811C986B054B37" modified="2021-04-07" version="1" fragment="single">MPDEKKLAEYLKWVTADLQKARHRITELESGRSEPIAIVGMACRYPGGVTSADDLWQLVRDGRDGISEFPTDRGWDLDGLYDADPDTPGTSYTREGGFLDGAADFDAGFFGISPREAVAMDPQQRVLLETAWETFEQAGIDPTSLETSKVGVFVGSVDQTYLGLEGPSDLEGYLMTGKLSSVVSGRVSYSLGFEGPAVTVDTACSSSLVALHLAAQSVRSGESSLALAGGVTISGTPGGFVDFSRQRGLAEDGRCKSFAGAADGTSWSEGVGLLLVERLSDAVRRGHQVLAVLRSTAVNQDGASNGLTAPSGPSQERVIRQALAEARFDSSDVDAVEAHGTGTRLGDPIEAQALLATYGATRPAEPLWLGSLKSNIGHSVAAAGVGGVIKMVQAIRHGVLPRTLHVDEPTPLVDWSAGAVELLTEERAWPETGRPRRAAVSAFGVSGTNAHVILEQAPRAAEPTAARTESGSQLPVVAWALSAKAADGLRAQARRLLSHVERHPGLSVPDVAHALVTTRAALEHRAVVVGTDRDALLDGLRSFALDEAGSTSPSDVARPGRLGFLFTGQGSQRPGMGLELRAAYPVFAEAFDAVCAEADPYLDRPLREVIETGDRLDETGYAQPALFAFEVALARLAESWGVRPDFVAGHSVGELAAAHIAGVLSLADATAVVTARGRLMQALPAGGAMVALQATVEEVEPLLATRAGRVGIAAVNGPTSTVVSGDEDVVADIAATVRAWGRATKRLTVSHAFHSPRMDPMLEEFGAVVRGVTFGAPAVPLVSSVTGRIATEEELRSPEYWIDQVRRPVMFLETVRTLAAQQVNTLLEVGPSGVLSAMVDDCLPGGAAVLPVAAVRSGRPEPDAVVHALGRLWSAGVPVDWAALFAPAGPRRVELPTYAFQRERYWVEAAAPAEGPRSGGPVADHPLLDAVVEVAGRDELVFTGRLSARAEPWFEGHRLFGSPVAPSSALLDMVVRAGDEVGCPVVDELVVDRPVALPERDPLRVQITVGPPDGAGARPFTVHTAGEGVRPAWTACASGVLGTGGRALPFTLGAWPPVDAEPLPVPEKAAEGDGAGAPSGPVALWRRDGELFAEARLEPGASADGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAA9</accession>
    <name>A0A7K2ZAA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_08100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000371">
        <property type="protein sequence ID" value="MYW29242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="357" mass="36192" checksum="AC60D14A580DC9C5" modified="2021-04-07" version="1">MPQVLAKTTEPPPTEPPPAAPSRSSRRRTRRLLGLGAAVGALLVAVLLSVAIGSAMLPLDVVWQALTAPDGSATHATVSGARVDRTLLGIVVGMSLGVAGALMQALTRNPLADPGVLGVNAGAGFAVTLGVAVFGVTRIEQYLPFAFVGAVAGAAVVYLAASGGRAGPSPLRLTLVGVAFTAVLNGVSQTLALIDTETFDRMRFWGAGTVTDRPTGTAGDIVPFVLAGLVVAVCCARPLNAIALGDDAGRAVGLRVGATRCGVVVAVALLCGAATAAAGPLMFVGLMVPHAVRWLTGPDWRWILAYSAVLAPAIVLVADVLGRLIVIPAELPVGVMMPVIGAPVLILLVRGSRVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAJ5</accession>
    <name>A0A7K2ZAJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.99.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_08860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.61" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000407">
        <property type="protein sequence ID" value="MYW29387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="11"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="208" mass="21611" checksum="4D852A00D8E344DF" modified="2021-04-07" version="1">MHQYEKDGPAIYRQSFATIRAEADLAGLPADVSQVAVRMIHACGMVDLVTDLAFSPNAVADARAALRSGAPILCDVAMVASGVTRKRLPANNDVVCTLSDPSVPELAAKMGTTRSAAALELWRDRMEGAVVAVGNAPTALFRLLEMIEEGAPRPAAVIGVPVGFVGAMESKEALAEHASGLEHLIVRGRRGGSAIAAAAINAIASEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAP1</accession>
    <name>A0A7K2ZAP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="7">1.13.11.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hppD</name>
        <name evidence="7" type="ORF">GT040_09050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000413">
        <property type="protein sequence ID" value="MYW29420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="184"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="381" mass="41855" checksum="530649CAEEE80A50" modified="2021-04-07" version="1">MTETLHTSPDTAAQADRFPVKGMDAVVFAVGNAKQAAHYYSTAFGMKLVAYSGPENGSRETASYVLTNGAARFVFTSVIKASTEWGTFLSDHVAEHGDGVVDLAIEVPDARAAYAYAVEHGARGLTEPHEVKDEHGTVVLAAIATYGKTRHTLVERSGYDGPYLPGFTPAKPIVEPPAKRTFQAIDHCVGNVELGRMNEWVGFYNEVMGFTNMKEFVGDDIATEYSALMSKVVADGTLKVKFPINEPAIAKKKSQIDEYLEFYGGAGVQHIALATNDIVATVRSMRAAGVQFLDTPDSYYDTLGEWAGETRVPVETLRELKILVDRDEDGYLLQIFTKPVQDRPTVFFEMIERHGSMGFGKGNFKALFEAIEREQEKRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAT6</accession>
    <name>A0A7K2ZAT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000422">
        <property type="protein sequence ID" value="MYW29477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="235" mass="24964" checksum="FD1773300C97789B" modified="2021-04-07" version="1">MTSVPVRCPACSRDHTYVAPAYPCPCGAPTAPPLLPGAPALQVTRRTWDEDWVTVRCTACDRQDQWPQPELCCPCGALLRIPVRPVDEPEPAPPPGPAHIPLPRTAAHPRPSFRPRTIRTGHDAVSAAALYLTWLGYREVARPRVRTAGGIDLRATGLVAQVDATTRPVELRAVECLWLNALGASAAGVFFSLAGYGAQARARADGVGLPLFVMDLTGAPQPVNSPADELVSTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAY6</accession>
    <name>A0A7K2ZAY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000444">
        <property type="protein sequence ID" value="MYW29516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="72" mass="7755" checksum="69A38FE0D50A5F16" modified="2021-04-07" version="1">MISETSAEDASELAWFRSSYSDSSNSNECVEVTIAQSVVHVRDSKNPHGPRLALAPTAWAAFVPYVGGDEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBB7</accession>
    <name>A0A7K2ZBB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_10310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000472">
        <property type="protein sequence ID" value="MYW29660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="32840" checksum="A134569B38993121" modified="2021-04-07" version="1" fragment="single">MHPQRDRAQLTMKDVSKAYGDRSVLDQVTLTVRPGEKAAVIGENGSGKSTLLRLLAGTERPDSGEITVRFPGSTGYLAQTLALDPADTVQDAVDAALAGLRALEVAIREAEESLSAGREATEAELAAYGDLLTAYEERDGYRADARTEAALHGLGLAHLTRDRALSTLSGGEQSRLALACVLAAAPELLLVDEPTNHLDVRAVHWLEDHLRAHRGTVVAITHDRAFLERVTSVILEVDRDLRTVTRYGDGWDGYRTAKEAARRRWAQEHQEYLSDLARTAELVDAAGARLAATGKDPKQGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBE1</accession>
    <name>A0A7K2ZBE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000469">
        <property type="protein sequence ID" value="MYW29654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="22222" checksum="8EAB8B307FE2EF98" modified="2021-04-07" version="1">MAPRILLARHGQTQWSVQGNHTGRTDIPLLDTGREGAKLLGERLHRAPWGGLPGVEVRTSPLVRASETCELAGFGERAEPWDALMEWDYGAYEGLTPAQIKADRPDWLIWRDGVPEGESLAEITARADEVVEWARSADRDVLVFAHGHILRVLAARWLGEDISFGARLRLEPTSLSVLAWAYGLPALERWNDTGHLDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBG0</accession>
    <name>A0A7K2ZBG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA starvation/stationary phase protection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_10250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000468">
        <property type="protein sequence ID" value="MYW29648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="16872" checksum="7FBDF8213559BBC2" modified="2021-04-07" version="1">MSVVKSPLSESDLKLVGEALQGALVDLVDLSLVAKQIHWNVVGPRFRSVHLQLDDVVVTARQHSDTVAERASAIGVNPDGRSATVSKETAIRAVPEGWIKDTDAVKALVDALGVVISRMRERIEVTDAPDPVTQDILISLTADLEKHAWMFQAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBG3</accession>
    <name>A0A7K2ZBG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000489">
        <property type="protein sequence ID" value="MYW29711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6159" checksum="05E82E818FAF5A3F" modified="2021-04-07" version="1">MAVTLSLVALFGLVLFFLLRSGSLTPGSAFTAAGFGFFLASTGAAGPINEMAAAIVDAIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBX0</accession>
    <name>A0A7K2ZBX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_11240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000507">
        <property type="protein sequence ID" value="MYW29839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="332" mass="35206" checksum="A26CFE8437C51236" modified="2021-04-07" version="1">MGWTVLYIAFGLVALWLLGEVLLQYKARLRWRLLAFGGFLGVVMGVLLASVPVIVVGTLAFATGQTYVTLSFRRGFSTGWAIGGSPGESRRRRGGERAAAKEPTLEVSGLEVSDPAAEPAFDSFGNGNGNSTGAPATASDDPAPVTSVYEPQPLPDDTGQYGVYSDSGYAADGPGQGSQDPYPYETDPAAQPQFAAYDPYSGYDQQQAQDTYAGPYDYGTGQQSYAAYSDPYIGTTNGTAPYGGYDAYGNGGNGYDSQGGQQSYADPYAQSYGTDAYTTDTPPGGVWVPQQRDAEQYPPMPPEQPAPYGQSNGNTNGNANGYDTGQNEQYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCL0</accession>
    <name>A0A7K2ZCL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Squalene/phytoene synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_12115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000555">
        <property type="protein sequence ID" value="MYW30005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW30005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="338" mass="36875" checksum="95D2B905BE3F62AE" modified="2021-04-07" version="1">MTVRELDAAGIHDPALRAAYTHCRGLNARHGKTYFLATRLLPVDRRPAVHALYGFARWADDIVDDLDSAATPAERGRALLALEAQLEAGLLREGATEPVIRALADTARRYGIDRVHFTDFLASMRSDLTVGGYASYEELGRYMHGSAAVIGLQMLPVLGTVTPREEAAPHAAALGVAFQLTNFLRDVGEDLDRGRLYLPAELLAAHGVDRERFEWSRRTGARDARITDVLRAAAAHNRAVYRDALPGIAMLAPVSRPCIRTAFVLYSGILDAIAADGYAVLHRRSIVPRRRRAVVALDGLVRAVAVRAVSRRDEEAPVAGPSSPSPRPRVATVREEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCQ1</accession>
    <name>A0A7K2ZCQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_12720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000598">
        <property type="protein sequence ID" value="MYW30124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="300" mass="32370" checksum="001B2661141DEB9E" modified="2021-04-07" version="1">MERFVDVAPGVRLWVEERGAPDAPALLLVMGALASGLGWPEELVASLAERHRVIRYDHRDTGRSTWSFDEQPYPLTALAENSVAVLDALGVERAHLVGMSLGGMLVQLTVADRPERVLSATLIGTGALSSVPYERPDGTRIPAEELPGASPALLELWSRPVEDHGPEAELERRVEHWRALGGDRIPFDASCAREQERRIIAHTGHHHAGTAHARADASGMDRTEALAQTEVPTLVISASAEPVYPPPHAHHIAQAVRGARLVEIPGMGHALPREVHAPLAAAILEHTGRTDQTGRADRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD65</accession>
    <name>A0A7K2ZD65_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="11" type="ORF">GT040_13610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01000651">
        <property type="protein sequence ID" value="MYW30297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW30297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="817" mass="82465" checksum="B68418E1769BCDF4" modified="2021-04-07" version="1">MAEFFTTPMAAPAVPAAPTQESALSDGPVSLAAAVLTDDNRLIVIIVAVVAVAALIVARLLVRQVLAAGEGTERMKEIAAAVQEGANAYLARQLRTVGVFAVIVFFLLLVLPADNWSQRAGRSLFFLVGALFSAATGYIGMRLAVRSNVRVAAAAREATPGEGEPEKDLTTVAHRATKIAFRTGGVVGMITVGLGLLGASCVVLVYAADAPKVLEGFGLGAALIAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVAALILGMAAFGDSGLAFPLMVPAIGVVTAMIGIFAVAPRRADRSGMTAINRGFFISAVVSLVLVAVAAFAYLPSSYAGLTGVTDEAITTHGGDPRVFALVAVAIGIVLAALIQQLTGYFTETKRRPVQDIGKSSLTGPATVVLAGISIGLESAVYTALLIGLGVYGAFLLGGTSIMLALFAVALAGTGLLTTVGVIVAMDTFGPVSDNAQGIAEMSGDVTGAGAQVLTDLDAVGNTTKAITKGIAIATAVLAAAALFGSYRDAIATAVADVGAGAGELGLSLDISQPNNLVGLILGAAVVFLFSGLAINAVSRSAGAVVHEVRRQFREHPGIMDYTEKPEYGRVVDICTKDALRELATPGLLAVLAPIAVGFSLGVGALGSYLAGAIATGTLMAVFLANSGGAWDNAKKLVEDGHYGGKGSDAHAATVIGDTVGDPFKDTAGPAINPLLKVMNLVALLIAPAVVQFSYGADANPWIRAAVAVFAVVVIVGAVYVSKRRGIAVGDDDSGAPDGGGPSLPSPDPAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDH2</accession>
    <name>A0A7K2ZDH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_14280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01000665">
        <property type="protein sequence ID" value="MYW30417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="270"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW30417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="490" mass="52012" checksum="8716EA279542F40F" modified="2021-04-07" version="1">MSEAAPPVSEAAPPRRALVRRFRALPLRSRLALLVATAVAVAVAAVAVACWFVTRIQLEDQLDDSLRNAKMDNEPMRDLLSSCLSGGQLPAQEFPGQYTVQIVAANGSYCTAPNTTPVPAQPSDVDVAAGRKTDALHTTENDDGKGMRVYTRKLPPVVSSGQANNQLAVSVARPLSEIDAPLSTLAWVLALVGGIGVVGAGAAGLWVARSGLRPVDELTEAVEHVARTEDLTVRIPVDGEDEIARLSHSFNSMAAQLASSRDRQAQLIADAGHELRTPLTSLRTNVELLARSDETGRVIPPDDRKALMASVKAQMTELAALIGDLQELARPDAAEPGPLQVVGLHDITRTALQRARLRGPELTITADLAPWYVRAEPAALERAIVNVLDNAVKFSPPRATIDVRLHRGELTVRDRGPGIPAEELPHVFERFWRSPSARQLPGSGLGLSIVARTVQQAGGDITLRPAPEGTGPGTVATITLPGAPTPPPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDT1</accession>
    <name>A0A7K2ZDT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_14775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000702">
        <property type="protein sequence ID" value="MYW30511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045598">
        <property type="entry name" value="DUF6457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20058">
        <property type="entry name" value="DUF6457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF6457" evidence="1">
        <location>
            <begin position="71"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15108" checksum="679950D7A3574A5C" modified="2021-04-07" version="1" fragment="single">RDQPLVAVYRGEPLRRELALIATEHGGLAGLPLRLLTGELDLARVDAGPYAAFDCDTWDDIAAARARIREHGAVLDEWITSVKNELGIELDVDTDVLLDLARDAAHGVARPAAPLTTFLVGYAATRASAGAGPEEAAAAVAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDT6</accession>
    <name>A0A7K2ZDT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_14695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="WWKE01000690">
        <property type="protein sequence ID" value="MYW30496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="248" mass="26355" checksum="C4903233753D633B" modified="2021-04-07" version="1">MTAPVFVVERMPTGPEFVLDGPEGRHAVSVKRLQPGEDVVLTDGLGHWADGTVRAAEGKDRLTVTLRAAVQEEPEPTPRITVVQALPKGDRGELAVETMTETGVDAIVPWQAARCITQWKGERGAKTLTKWRSTAREAGKQSRRVRFPEVTEAMTTKQVAALLAGADLAGVLHEDRDHDSTPLATAELPATGTIVLVVGPEGGVSPQELAAFAEAGARPYRLGRSVLRTSTAGTAATALLLGRTGRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDU8</accession>
    <name>A0A7K2ZDU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000697">
        <property type="protein sequence ID" value="MYW30506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="163" mass="17484" checksum="2CD8FAFFC6DC662C" modified="2021-04-07" version="1">AHADRPDWAGQATGSGAAARRMWSKQPRASVLLPTGRTFDALEVPESAGFLALARMERMDLTLGPVTCTPDRRMLFFVLPGGAGKAPELVRGLGWNAEAIDLTGRGEGHYIAAPPTRVGGRGAVQWARKPTHVNRWLPDVDELISPLAYACGREAADARTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDV1</accession>
    <name>A0A7K2ZDV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_14710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000693">
        <property type="protein sequence ID" value="MYW30498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043746">
        <property type="entry name" value="DUF5691"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18944">
        <property type="entry name" value="DUF5691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="398" mass="42234" checksum="74DEF7C11C1173D2" modified="2021-04-07" version="1">ARARTDLRPQALAFAGPLGLWLAALNPEWKFALRGGAGGSLVPDTGDPDAVHRLWEEGLFAERVALLDAVRTRDPAAALALLTTSWSTERAEDRLMFLDSLRNGLGAEDEEFLEQALADRSRNVRATAAELLSALPASAFAGRMAARATSCVNPDRTGAGASIAVEAPHECDAGMRRDGVVADPPTGRGERSWWLGQLVEATPLGVWQERFGGRPAAEIVALPVADDWAGELHAAWCRAAVRQRHPEWARALLGEPSAPPAGTPGPTSIAERSKLLAVLSEAERADWVAAFIAAHGLSEAFQLLGVCTVPWSGPLGRAVVDALDIARDGGSYPWSFSGVMGLAERCLGPAEADRLEVLTATPDEQEGASPGAGGYWSEAFQRLVSTLRLRAAMEAELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEM7</accession>
    <name>A0A7K2ZEM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_16405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000765">
        <property type="protein sequence ID" value="MYW30814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="15"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="27103" checksum="44FE24FF73D37A70" modified="2021-04-07" version="1" fragment="single">MTHPFLDLPPLTAAHFAAIERRVAALLATEQDVVITQGEALLPLEGCIRSGARPGSTALNVVTGPYGQTFGNWLRDCGAEVVDLTVPFHTAVTAGQVAEALAEHPEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFMLDAVASVGAEPLLPDAWGVDLCVIGAQKAMGGPAGVSAVSVSERAWERITANPAAPRRSYLSLLDWKERWIDGGRTALPHAPAQLEMLGLEACLERIEEDGLDAVMARHASAAAATRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEP6</accession>
    <name>A0A7K2ZEP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Magnesium-chelatase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000765">
        <property type="protein sequence ID" value="MYW30821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="52" mass="5217" checksum="508411CBE994059D" modified="2021-04-07" version="1">SVVVDCESGYVRLGLAGELARELGGTAVTLDELRADSIAGLVKDVTAAGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF93</accession>
    <name>A0A7K2ZF93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000811">
        <property type="protein sequence ID" value="MYW30988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="178" mass="19878" checksum="73988BEF412A124F" modified="2021-04-07" version="1">MSIAPVPPTAPAPAVRLRVPTDEDALFWHRIFDDPEVMEFFGGRRADFSVYEELTARQRRHDAELGYCLWTVTDEDGTVLGFTGAQPWPHSHYGPVGAIEIGWRLGRSAWGHGYATVAARTTLERLRAAGVPDVVAMIDSRNARSIAVAERLGMRLAETFTTPRPGQEARCYRLELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFJ7</accession>
    <name>A0A7K2ZFJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000846">
        <property type="protein sequence ID" value="MYW31096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16676" checksum="980ABB3A40D23178" modified="2021-04-07" version="1">DDGRRALAEVGLERHADAWPATLSGGEAQRVALARALVREPELLLLDEPFAALDALTRLRMQDLVDELCRKHRPAVLLVTHDVEEAVRLADRVAVLRDGRLVTDERVTVARPRDPGDPAFAALRRRLLDDLGVPAPSHPVRTPELDRVGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFT1</accession>
    <name>A0A7K2ZFT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoenolpyruvate synthase</fullName>
            <ecNumber evidence="4">2.7.9.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ppsA</name>
        <name evidence="4" type="ORF">GT040_18515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01000865">
        <property type="protein sequence ID" value="MYW31213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="3">
        <location>
            <begin position="20"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="2">
        <location>
            <begin position="797"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="872" mass="94804" checksum="08C07ED5F548C6E6" modified="2021-04-07" version="1">MTMRRTGLLDLHEADATQLALVGGKGAQLGALSRIDGIRVPDGFCVTTDAFRRVVARVPSLDDRLDRLSRSDPDDREALRTLSADVRRTIEETVLPGDLAAEIAGALARLGEGAAVAVRSSATAEDLPTASFAGQQDTYLNVVGQAEVLRHVSRCWASLFTERAVAYRRRNGIDHRTVQMAVVVQRMVFPEAAGVLFTADPLTGNRRTATVDAGLGLGEALVSGLVNPDVFTVRDGAVVARAIAAKQRAVHALPGGGTREVEVDPQRRERPALTDAQVLRLVELGRRIEAHFGRPQDIEWCLADDGFRIVQSRPITTAYPIPDAGDQERHIYVSVGHQQMMTDAMKPLGLSLWQRTAMVPMHEAGGRLFVDVTPRLASPASRAALLDLVGRGDPLVRDALETVLDRDDPVPPLPDTGPGGPPAGAASERSAEADPAIVPELIERSRASVAALERDLRAKRGPALFDFLLEAFEEHKRVLGDPLSMRAITAGMEATWWLNDQLGVWLGEKNAADTLTLSAPGNITSEMGLDLLDVADVIRPHPEVVAFLKGVEKGAEDEGFQDELAKLPGGTEAREAIDAYLDRYGMRCVGEIDITRPRWRERPTTLVPLILDNVRNFGPGAAAHRFEQGWARARLKEQDVLSRLRALPDGDRRAEAAKRMIDQVRAFAGYREYPKYGIVSRSFLYKQALMEEAGRLVQADVLCEREDIFYLTFPELHDVVRSQQADDRLIRQRKEAFRSYGTLTPPRVLTSDGEALTGAYRREDVPAGALAGLAVSTGAVEGRARVVLDLADADLGAGDILVTRFTDPSWSPLFLGVAGLVTEVGGLMTHGAVIAREYGLPAVVGVEGATRLIRDGQRIRVHGTDGYVELLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFT3</accession>
    <name>A0A7K2ZFT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_18170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000859">
        <property type="protein sequence ID" value="MYW31145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="272" mass="29668" checksum="C08C5C9457181EBB" modified="2021-04-07" version="1">MERPAWAPQGIDISVPSVSRMYDFYLGGSHNFEVDREAARKAMEFLPGLPKIMQANRAFMRRAVRYAVGQGIDQFLDIGSGIPTFGNVHEVAQAADPRAKVAYVDHDPVAVAHSQAVLEGNDLAVIAAADLRRPKEILANPVITGLLDLDRPVALLLVAVLHFIEDADDPRAAVAELREALAPGSLVILTHASYEGIPLSKEEADGTVGVYRNIRNPLIMRTHEEIGAFFEGYEMVEPGLVSMPEWRPDTPQSPEQEDPYAFSGFGGVGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFY7</accession>
    <name>A0A7K2ZFY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_18880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000876">
        <property type="protein sequence ID" value="MYW31281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="11"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="260" mass="28295" checksum="C889C8B0B1E60FA6" modified="2021-04-07" version="1">MTVTAERMPALYLSHGAPPLADDPVWPGQLAAWSATLPRPRAILMVSAHWEEAPLALGAVEPVPLVYDFWGFPEHYYRVRYGAPGAPRLADSVRKLLRGAGTPVQDIPDRGLDHGAYVPLVEMFPDAGIPVLQISMPTLDPQKLMAIGRKLAPLRDEGVLIVGSGFFTHNLAALRHTGGGVPGWSAEFDDWGDRALRAQDVDALLDFEHTSPAGKLAHPRTEHFAPLFVTLGAAEEELDRGRSVIDGFWMGLAKRSVQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGK9</accession>
    <name>A0A7K2ZGK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000926">
        <property type="protein sequence ID" value="MYW31472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029537323" evidence="3">
        <location>
            <begin position="34"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="243" mass="23396" checksum="CFE4F6FE16A04EA8" modified="2021-04-07" version="1">MSNQKRTALALTAALTVAMAGSAVLMAAPAAHAEVVDVNYQCETPIGPKGAVSPIDIKSVKSGSGYKLTMSFQKGVSSSPVELGKGAMNPSAVIEVGGAETGKVQVSGPANAEAIPANTPIKISDLSGTYTPKKSGKVTFTAGVLTIKALGTTTTCTPKNSPGPSLQLDVQGAGGSGGSGGSTGGSTGGGSTGTGGSGSGGGELPKTGPLDSAAALGTLGGTVLLTGAAGVLWLTRRGQRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGQ2</accession>
    <name>A0A7K2ZGQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000941">
        <property type="protein sequence ID" value="MYW31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="310" mass="31983" checksum="8040A0DC15A37E16" modified="2021-04-07" version="1">MVLLGVAAIVLLGIAYGAGLLLNHSEVPKGTTVLGVDIGGGTKEEAVTKLDAALGERSQAPLTLSVDGKEQKLDPAKAGLVLDSQETVRGAAGSDYNPVSVIGSLFGGARTADPVIPVDEEKLGVALTDLAGVAGSSQDGTIRFEPNKAVAVPGKPGKTLDVGQSLISVRDAYRAQVQTGQARVVELPVATREPTITQAELTRAMKEFAEPAMSDLITIKAGPKQIQFGPARSLPQILSMKAVDGRLVDVYDKEAITTLLDGVFDGIEAVKADGTKHPVGADDVAQAMKTALTGKTPAERTVTINLTGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHB5</accession>
    <name>A0A7K2ZHB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001014">
        <property type="protein sequence ID" value="MYW31746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="376" mass="42497" checksum="327C391E9ED621FE" modified="2021-04-07" version="1">MGDVVRAPWNGYFVTGFDTCSQVLRGRTWLAPDFAWQERQDDSKQWDAIATREMTGTLARLNAPEHTCQRRSFGNLFDRSTIERLTPDVERDADRLLDELADKLRWGEADFVSTVSEQLPIHTVGSWLGLPPEDYPHILEITHNQVYAQELLPTRSQLAVSAGATLQLRAYFTDLVARRRAEPRHDVLTGWIHTWDAMEPDRERADEILYRLTMFVTIASLETTATLLTSMTSLLLADPGRWQWLRDHPEHIDAAVDEVLRYDPPIHINTRIAAEDTVLAGVPIKKDSMVHVLYGAANHDPRRNPGPETFDILRGGSHLTFGGGVHYCLGAALAKLEARTLLARMLDRFPTLRSTSPPVYAPRMVFRRITSLGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHY9</accession>
    <name>A0A7K2ZHY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001062">
        <property type="protein sequence ID" value="MYW31970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="170" mass="18309" checksum="E8F27D76360427FB" modified="2021-04-07" version="1">MELEQRVAELERRLTALERQDPEPASPRLGDGDFWALEGLKQRLADAGEAGADGGVLYTGSVRLPTGEQYGWQYGAFTEALFDGDWADTAESSAALGHPVRLRLLREILGGLRTAAELAALDGVGTTGQIYHHLRQLTGAGWLHAAGRGRYEVPPARVVPLLVVLTAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI52</accession>
    <name>A0A7K2ZI52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_22760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001066">
        <property type="protein sequence ID" value="MYW32017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="320" mass="35262" checksum="37A50DB392AD438B" modified="2021-04-07" version="1">MTGIGDTSKDDKAWAMEIIDQINRGTREAHERRDALAAAVDEIANGFTQLGLKPWKMKRKSPAREDEKASDVLLGDRSERVAKILRYESAVNILSAADQLRGFAVLLRAEASLMGAVSVARGIFEACLWATAVIDPTITTDERLKRALTRRLARLSAGIRLKDMLGDGVTDADQVIEDDGDFDDEHGTNRDPAKDIDDIVNYAEGRGWKVKKGRRASEITPLSIDWLSENLERRIGIEGYAWTSGSSMAHGEHAADTASWVELSQDLGTAPAWLIQLWSTGAWAGPRIFLATLANYTGRASLGREYQRFEELFLNEGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIW6</accession>
    <name>A0A7K2ZIW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_24240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001134">
        <property type="protein sequence ID" value="MYW32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="228" mass="25100" checksum="A130A2497D92AD6F" modified="2021-04-07" version="1">MPLSSPSPSRGPAAPTRILLADDHALVRRGVRLILDGEPDLTVVAEAGDGAEAIEMARAERPDLAILDIAMPRLTGLQAARELSRVLPGLRILMLTMYDNEQYFFEALKAGAAGYVLKSVADRDLVEACRAAMRDEPFLYPGAVTALIRNFLDRAKDGEDLPTRAITEREEEILKLVAEGHSSKEIAELLVISVKTVERHRANLLQKLGLRDRLELTRYAIRAGLIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ72</accession>
    <name>A0A7K2ZJ72_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_24725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001155">
        <property type="protein sequence ID" value="MYW32385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="183" mass="20037" checksum="21458D93E814ED46" modified="2021-04-07" version="1">MEMPRNDRSQEHPQVLVVGQDGMAIGGGASDDESREVPVTEMVEQPAKVMRIGSMIKQLLEEVRAAPLDEASRVRLKEIHASSVKELEDGLAPELVEELERLSLPFTEESVPSEAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLEQMRRALPPGMAHEDEEGGGADPHGPIRSGPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJA3</accession>
    <name>A0A7K2ZJA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001162">
        <property type="protein sequence ID" value="MYW32418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="82" mass="8602" checksum="0F93AF14BBA2D340" modified="2021-04-07" version="1">MAKKNRSAPAKGLRGSKVGLALSLGSSALAVIRASKQVRRAKGSHDKLNTADAVAGMLPLITSAALILRQLRGRRQENPETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJG8</accession>
    <name>A0A7K2ZJG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073878501.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001194.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="27918" checksum="6E150CF0CE294680" modified="2021-04-07" version="1">MGADGGSSGSETGNGARTARVPKYYRLKRHLLDMTDTLPPGTPVPPERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQGLEPTSQLLDIGYVTADDTLAGLLDISTGGRVLRIERLRLASGEPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVRLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSIDGQGEPVEWVRSVYRGDRYKFVARLKRPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJH1</accession>
    <name>A0A7K2ZJH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">GT040_25305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001194">
        <property type="protein sequence ID" value="MYW32496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003953983.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001194.1"/>
    </dbReference>
    <dbReference type="GeneID" id="63982693"/>
    <dbReference type="GeneID" id="66955643"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW32496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="85" mass="9644" checksum="9D34DEC1E098A00C" modified="2021-04-07" version="1">MDWRHNAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQCLQWALESGQDSGVWGGLSEDERRAMKRRAARNRARNASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJP1</accession>
    <name>A0A7K2ZJP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_25675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the melC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023199">
        <property type="entry name" value="GriE/MELC1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010928">
        <property type="entry name" value="MelC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06236">
        <property type="entry name" value="MelC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029567504" evidence="4">
        <location>
            <begin position="32"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14402" checksum="B3B7EE473C92522C" modified="2021-04-07" version="1">MPQLTRRRALGATATVVTGLVLTGFARTAGASSEPRTADPKHNAEHEGHAGHAGHEGPQPFSETFWGRRIEGAPSHGDGHHGGYAVQIDGEELHVMQNADSTWVSVINHYETFPTPRAVARAAVIELQGSGLVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK16</accession>
    <name>A0A7K2ZK16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001223">
        <property type="protein sequence ID" value="MYW32687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="371" mass="38949" checksum="75F7C1E8BCF733DD" modified="2021-04-07" version="1">MSTGTTAVWGRAEQQDFRSRVRGALLGGAVGDALGAGVSGLALEEIREAHGAEGVTDYVPAHGRRGAVTALTQLTLFTVDGLIRAQVRRDTGAWHPPTDVHRAHLRWAATQHDWGPDERRKDNGWLAAEEWLYARRGPTRECLGGFGDTVMGTLERPKNPTARDAGALTRSAPFGLLVGWEPQLVLQLAVECAAQTHGQPAAQLAAGAFAVLVHALARGENLDGAVQHAMALLGERPGHEPVTEALQQALGSVRQGIPGPALIEALGASDAAEEVLAVAVYCALVSQDVRHGLRLAVNHGGPSRATGAVCGALLGVLHGETALPPAWLAELEGRPTLLELADDFAMEMTQGPALHSPTAAAPGWLARYPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKC4</accession>
    <name>A0A7K2ZKC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylisocitrate lyase</fullName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prpB</name>
        <name evidence="4" type="ORF">GT040_26850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001252">
        <property type="protein sequence ID" value="MYW32793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="301" mass="32267" checksum="38A0E03723596401" modified="2021-04-07" version="1">MLHTRTTPAGRRRSFREQLSSGRLLRMPGAVNPYSARLIQEAGFEAVYLSGAVLAAELALPDLGLTSSTEIAARAQQIARVTDLPALIDADTGFGEPMNAARTVQLMEDAGLAGLHLEDQVNPKRCGHLDGKTLVGRSEMARKVRAAVDARRDPDFLLMARTDARGPEGLEAAIDRAKAYVDAGADAVFPEALADEAEFEAFRAAVDVPLLANMTEFGRGPLLDAATLENLGYNIALYPVTLFRLAMGAVEDGLAALAADGTQQALLPRMQTRSRLYEVLGYEEYGAFDSAVFDFTLPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKI4</accession>
    <name>A0A7K2ZKI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001261">
        <property type="protein sequence ID" value="MYW32843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="353" mass="38945" checksum="D8F715A8B84BA3BC" modified="2021-04-07" version="1">MSQATATAVDPVGDGSSERSGLPAAGSDFAPLLRAVKGQGLLERRTGRYAISIAANLVALGGAIAAFVLLGDTWWSLFLTPPLAVLWTRTAFVAHDAGHSQISGDRRASRLIGLLHANLLLGMNEAWWNDKHVRHHANPNHVDKDPDVGVGALVWTQKQATQREGFARWLTRNQARLFFPMLLLEGIALKVYGFQFLRHQPARERAVSALLMTAHLALYATLLLTVLSPGKALVFALLLHALFGLHLGMAFAPNHKGMEMPDPDGDRWSHLQRQVLTSRNVRGAVLTDWFLGGLNYQIEHHLFPSMPRPHLRLAQPLVKEHCRSIGMPYAETGLAESYRQALAHMHEVGEPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKJ2</accession>
    <name>A0A7K2ZKJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_27165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="WWKE01001263">
        <property type="protein sequence ID" value="MYW32853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0033" evidence="5">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="231" mass="24358" checksum="6131E8A62CACFAD4" modified="2021-04-07" version="1">PGFENLPAIVAAAASLRAVRDEAAAEAVRLRALVGRIRSVVAERVGDVEVVGDPERRLPHLVTFSCLYVDGETLLHELDRHGFSVSSGSSCTSSTLEPSHVLKAMGVLSEGNVRVSLPVGTAEADVDRFLEVLPGVVAGVRERLGAPVSVPASPAPVASLVVDALGRRCPIPVIELAKVIGEVPVGATVTVLADDEAARLDIPAWCEMREQEYVGEEPADRGSAYVVRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKN2</accession>
    <name>A0A7K2ZKN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_27365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001273">
        <property type="protein sequence ID" value="MYW32893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="189"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="400" mass="43151" checksum="C388A96CF7A9D805" modified="2021-04-07" version="1">MQRLYDFLRRHPLGVDVFWAVVLLGLSGMSLVSGMFDAGREEILAIPVALGLSTVVALRRRLPEKMLLLAIAVGVLQLVGDVRPNIGNFAMLVITFTVATIGERWASRLALVCSLSAAALSQVRWEAEPGGSWPQQIFVTVIMTVPFVLAWVMGDSLRTRRAYFSQLEERAARLEREREAQSKVAVAAERARIARELHDVVAHNVSVMVVQADGAAYVMDAAPDQARQALETISSTGRQALAEMRRLLGVLRTGDAPESGEYVPQPDVKQIEDLVDQVRRTGLAVDFKVEGTARPLPSGVELTAYRIVQEALTNTRKHGGPDAGASVRLVYFDDGLGLLIEDDGRGAAHELYEDGGADGAGHGMIGMRERVGMVGGTLDAGPRPGGGFRISALLPLKPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKV5</accession>
    <name>A0A7K2ZKV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease E/G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001300">
        <property type="protein sequence ID" value="MYW32982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="12780" checksum="B4743FBFDEFFF473" modified="2021-04-07" version="1">AAPPRARRRATRKVTAPAGSPTGSQEAAVLVVESAPEPKAAEAPEAEAPASGEPDEAPVAKKTARKAAAKKAPAKKAVAKKTAAKKTAAKKTTAKTAAKKTTKKTVAAEQSSPSVTASAPSIDGEASTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKX1</accession>
    <name>A0A7K2ZKX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_27820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001299">
        <property type="protein sequence ID" value="MYW32978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="220" mass="23862" checksum="6808726BC84A3D58" modified="2021-04-07" version="1">MRLLIVEDEKRLAVSLARGLTAEGFAVDVVHDGLEGLHRASEGGYDLVILDIMLPGMNGYRVCGALRAAGHEVPILMLTAKDGEYDEAEGLDTGADDYLTKPFSYVVLVARVRALLRRRGAGTAAPVLTVGTLRIDTAARRVHRGEDEYVLTAKEFAVLEQLALRAGQVVSKAEILEHVWDFAYDGDPNIVEVYISTLRRKLGAASIVTVRGAGYRLEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL22</accession>
    <name>A0A7K2ZL22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_28145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001308">
        <property type="protein sequence ID" value="MYW33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="7">
        <location>
            <begin position="123"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="30382" checksum="1FC1957D80E5F2BD" modified="2021-04-07" version="1" fragment="single">MTAQILDGKATAAAIKSDLTVRVAALKAQGITPGLGTLLVGDDPGSRWYVNGKHRDCAEVGIGSIQRELPDTATQEEIEDVVRELNADPECTGYIVQLPLPKGIDTNRVLELMDPEKDADGLHPMSLGRLVLNETGPLPCTPQGVVQLLRAHGVEINGAHVVVVGRGVTIGRSIPLLLTRKSENATVTQCHTGTRDLSSHLRQADIIVAAAGVQHLIKPEDVKPGAAVLDVGVSRDENGKIVGDVHPGVREVAAWVAPNPGGVGPMTRAQLLVNVVEAAERTAAEAADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL36</accession>
    <name>A0A7K2ZL36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_28260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001311">
        <property type="protein sequence ID" value="MYW33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029906303" evidence="2">
        <location>
            <begin position="38"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="21154" checksum="167B7C0E81E0FF12" modified="2021-04-07" version="1">MRISRSVRSRRARTGAKVAVAVAVAGASLAGAPAAYAVPGDSGNIDIRSVSWHSNRGGVEVCKFVLSASNFESFPSVPWTITEQPPTVPPGTTLMDRLPLINGSARSEAYLLPEGTYQLVWVVPAGPKQRSFKVECDRGNYGSKPHKPIGGVPAGGGGVPDMASVSSENDSNATTTGAVLAAGAAGAAGLILMRRSARRRARGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL65</accession>
    <name>A0A7K2ZL65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001314">
        <property type="protein sequence ID" value="MYW33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="342" mass="35702" checksum="F7945B4180EF1D70" modified="2021-04-07" version="1" fragment="single">MSAERPILPPVRLHSEAELARDALAAPLFVRAVKLARWAGPDTRVGAGGELVEAHLPAAAEHLGLPADEEGAAYASEAWRLAVDTGLLDVTDPEEGELPDGAGGSEEAETEGTVTAGENLALITSGSPQDILSIWLDGLDAVHADATAPVLDDFADLVGEDGSIDFDALDWDPEAEAEFLDGVLGNLYLLTLADNGAGDGPVPLPALAASMIVPDDMGEPTDDILEQVSEAMMRLDDQFRLLEPIGIVAYQPVDEALMVEEGEPVDASAAGADEEDVTRYGMVKLTPLGLYGIRARMLEAGVDAPAVGDLADKGADTLLDGIAHYPEAAARAEIQLWLAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLA9</accession>
    <name>A0A7K2ZLA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001329">
        <property type="protein sequence ID" value="MYW33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="55" mass="5915" checksum="933B55C535AE6E76" modified="2021-04-07" version="1" fragment="single">MSQPRKNAAARSDTPARSDAVRNRERILRVAMAELTVRPDVPLSTIAKKAGVGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLE1</accession>
    <name>A0A7K2ZLE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_28790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001345">
        <property type="protein sequence ID" value="MYW33161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="11"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="444" mass="47260" checksum="4A6EB766D0115654" modified="2021-04-07" version="1">MTTTTEQLSATTLLRFATAGSVDDGKSTLVGRLLHDSKSILTDQLEAVEQVSLSRGQEAPDLALLTDGLRAEREQGITIDVAYRYFATTRRRFILADTPGHVQYTRNMVTGASTAELAVVLVDARNGVVEQTRRHAAVAALLRVPHVVLAVNKMDLVEYAEPVFAAIAEEFTAYAASLGVPEITAIPISALAGDNVVEPSAHMDWYGGPTVLEHLETVPVSHDLTACHARFPVQYVIRPQTAEHPDYRGYAGQIAAGVFRVGEAVSVLPSGRTTVITGIDALGESVDIAWAPQSVTLRLADDIDISRGDLIAPAADVPPVTQDIEATVCHVADQPLSVGQRVLLKHTTRTVKAIVKDIPSRLTLDDLSQHPAPGQLVANDIGRVVVRTAEPLALDAYEDSRRTGSFLLIDPADGTTLSAGMAGAAFAAVAEAVAQADDDAAWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLL4</accession>
    <name>A0A7K2ZLL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001355">
        <property type="protein sequence ID" value="MYW33226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561586.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001355.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029765102" evidence="1">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="100" mass="9194" checksum="4B800B53AA6D4F84" modified="2021-04-07" version="1">MKKTAAKTLGVAALGAAFAAAAAGSASAAPSLPLDTVAGALPVSTMALESVATAAQNAPVQETVGKVLGGDATDAAAPVTGLLGGLPTQGLTANGIPLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLT3</accession>
    <name>A0A7K2ZLT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplS</name>
        <name evidence="8" type="ORF">GT040_29450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001362">
        <property type="protein sequence ID" value="MYW33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073882311.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001362.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="13095" checksum="CC9844E1A46B1185" modified="2021-04-07" version="1">MTSLLDGVNAATLRSDVPAFRPGDTVNVHVRVIEGNRSRIQQFKGIVIRRQGSGVSETFTVRKVSFSVGVERTFPVHSPIFEKIELVSRGDVRRAKLYFLRELRGKAAKIKEKRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLZ7</accession>
    <name>A0A7K2ZLZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001387">
        <property type="protein sequence ID" value="MYW33381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="210" mass="21282" checksum="5D55C5D0B4EF6C43" modified="2021-04-07" version="1">MDGTLVDTEVLWWETAREVAAGLGHRLSDADAPEVVGRAVADTAAHLIGVTGGDPSELPGTAAELTDSFFRKVDAGAPLRPGAAALLASLEGAGVPFALVSASPRSVVDAVVAGSLAGVDFAFTLSADDTVRTKPHPDPYRAAAERFAADPASCVAVEDSPDGTASADAAGCAVLVVPSLLPVAPGRARTFARSLEEVDLGVLADCLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM14</accession>
    <name>A0A7K2ZM14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001389">
        <property type="protein sequence ID" value="MYW33403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YegS_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="84" mass="8766" checksum="5E22F2FA07D508EE" modified="2021-04-07" version="1">ADGLLDVRVVHGGRGPGLRMLAAAVAGPLTRSPAHAAVRRRRVRIAGLAPGTPYAYDGEVAHSGTELLIDKLPEALTVYCPMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM71</accession>
    <name>A0A7K2ZM71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_30335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001396">
        <property type="protein sequence ID" value="MYW33451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="267" mass="28957" checksum="1D425950B68F8675" modified="2021-04-07" version="1">MARFEHTVTVAALDRHWFEEAAGHAVDLFDASREQDGAILLPDGRPIHGLRLVKGRHLQSGARYGEDPEGKAGEDGKGAPEAAPESAVLREWRPSRTVEVESLVAEEGMSLRVGVRLREPRTPKALEVSLDGHNPEGGSLYRFSGRAKADLHAWWAALDRPSSAPAAARAPVVGTAKHRLGKARLTVTPRPAEDGTWQISVVLSVRGRWLLRPVAAVGLLFARRPVERGFREGVDSAAEEWAELLAELPSLHGEALRAEIADALTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMW6</accession>
    <name>A0A7K2ZMW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_31630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001443">
        <property type="protein sequence ID" value="MYW33695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="69" mass="7918" checksum="BA1D8833D777238B" modified="2021-04-07" version="1">MNLFLNYLTVTALFAFVALPAAIGLVRERRIDRQLRDAERGEVARTEPRSTARPYEVTRHSYPKGWAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMX6</accession>
    <name>A0A7K2ZMX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3107 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001444">
        <property type="protein sequence ID" value="MYW33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010061602.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001444.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="75" mass="7902" checksum="7CF25C8315504B30" modified="2021-04-07" version="1">MEVKIGVQHTPREIVLESGLSAEDVESAVAAALGGKAELLSLTDDKGRKVLVPADRIAYVEIGEPTTRRVGFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN20</accession>
    <name>A0A7K2ZN20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001450">
        <property type="protein sequence ID" value="MYW33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13271" checksum="25771478FA675E93" modified="2021-04-07" version="1" fragment="single">MTTTANRPPAKPSARRTPTGAAQRLEPLAERLLGGGLPVRVRMWDGSEAGPEDAPTVHVRSRRALRRLLWEPGELGLAEAYITGEIDLDEDLGDGLRAMRRAVAERGLTPPAPSLADRLSAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNE1</accession>
    <name>A0A7K2ZNE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_32210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001482">
        <property type="protein sequence ID" value="MYW33808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="103"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="322" mass="35109" checksum="348EE1790CD7FAC6" modified="2021-04-07" version="1">MKTTSQPAPPAATRPAGTAPPSGGARPAGRGPLGPLRRKIADQATAYAFLTGGLLCFILFSWYPAIRSVIIAFQKYTPGSDPQWVGTANFTRVFQDPEFTAAWRNTLTFTVLALVIGFAIPFVMALVLNELRHAKAFFRVVVYLPVMIPPVVSALLWKWFYDPGAGLANEVLGFLHLPTSNWTNGADTALVSLVIVATWANMGGTVLIYLAALQGIPGELYEAAELDGASLWQRIRHVTIPQTRFIILMLMLLQVIATMQVFTEPFVITGGGPENSTVTVLYLIYKYAFLYNDFGGASALSVMLLLVLTAFSALYLRLTRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNT0</accession>
    <name>A0A7K2ZNT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001517">
        <property type="protein sequence ID" value="MYW34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="408" mass="44416" checksum="EE942C116EB15ECB" modified="2021-04-07" version="1" fragment="single">GGETDPERGSRPSGPAQAPDRRRTALICLDLGEQLLHAGETTEAHRLLDRAVGLARDLDEPELLARVAITLYRRGTLGSGEAFMVRFLGEAHRKVTGKDGQDSLSADRLAQELAIHIMALARDGSDDEALAFSLWARHDSVWGLGSAVERLGLTDEMAVVGRRTQNLDMELHATSMRWVALLELGDPAFIDQYRTYIRAAERSELPRFALAVAVDGSLIASLQGRFTEAADALTGEALGMEGEDHEAIGFMRCHLHWSLHLLRGHFAAAEKVLATLPGARYPYPGLLEALTAVEQGDAAPALRLIAEQSDRASPYPRGFMPLWLRLLAQTATITGDRRLITRAEDELTPYTGQWVVSLYGCDIGGPVDLWLGMLAAARDDRDTAVATLTEAAASADRLGARPWAVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP54</accession>
    <name>A0A7K2ZP54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="9">2.8.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">miaB</name>
        <name evidence="13" type="ORF">GT040_33840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01001547">
        <property type="protein sequence ID" value="MYW34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="15"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="156"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="389"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MYW34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="492" mass="53854" checksum="EC6DAD9BF06EEA9F" modified="2021-04-07" version="1" fragment="single">MSSGNRSEEAVDVQKSYEVRTYGCQMNVHDSERLSGLLEDAGYVRAPEGADGDADVVVFNTCAVRENADNKLYGNLGRLAPMKTKRPGMQIAVGGCLAQKDRDTIVERAPWVDVVFGTHNIGKLPVLLERARIQEEAQIEIAESLEAFPSTLPTRRESAYAAWVSISVGCNNTCTFCIVPALRGKEKDRRTGDILAEIEALVAEGVSEITLLGQNVNAYGSDIGDREAFSKLLRACGKIEGLERVRFTSPHPRDFTDDVIAAMAETPNVMPQLHMPMQSGSDSILKAMRRSYRQERFLGIIEKVRAAMPDAAISTDIIVGFPGETEEDFEQTMHAVREARFANAFTFQYSKRPGTPAADMDGQIPKEVVQERYMRLSALQEQISWDENKKQVGRTLEVMVAEGEGRKDGATHRLSGRAPDNRLVHFTKPAQDVRPGDVVTVEITYAAPHHLLAEGTPLAVRGTRAGDAWEKRTTAAAAKPAGVMLGLPSIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPP3</accession>
    <name>A0A7K2ZPP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="9">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fabI</name>
        <name evidence="12" type="ORF">GT040_34810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:18179"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:10242"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="WWKE01001591">
        <property type="protein sequence ID" value="MYW34310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MYW34310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="255" mass="27233" checksum="2478C4B6A6360190" modified="2021-04-07" version="1">MSGILDGKRILITGVLMESSIAFHTAKVAQEQGAEVILTAFPRPTLTERIAKKLPKPAKVIELDVTNQEHLDRLEGLVREELGSLDGVVHSIGFAPQDALGGNFLNTPFESVATAMHVSAFSLKSLAMACKPLMSEGGSIVGLTFDAQYAWPQYDWMGPAKAALEATSRYLARDLGKDGLRCNLISAGPIGSMAAKSIPGFSELADVWNTRAPLAWDMSDPEPAGRGVVALLSDFFPRTTGEIIHVDSGVHMMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPW5</accession>
    <name>A0A7K2ZPW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_35305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001615">
        <property type="protein sequence ID" value="MYW34406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="72"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="227" mass="24542" checksum="8A4511FA98C95680" modified="2021-04-07" version="1">IPFALLLVLVEANWPPLRRVDAGAARRLHEVALEHPAWTGTLRVLSDWVWDPATLRIAVALLTLWLLYRRAWRLAAWAAVTATGGALTGVLVKVVVERARPSLEDPVAQAPGYSFPSGHAMTATTSFAVLLLVLLPMVPRTWRALCWGVAGVSVLGVGFTRIALGVHWFSDVIGGWLLGAAVVVLTGWAFEAWRADSGRRPTSVAEGLEPELTDEDPEPSDPGPRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ47</accession>
    <name>A0A7K2ZQ47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonylcarbamoyl-AMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001629">
        <property type="protein sequence ID" value="MYW34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="215" mass="22562" checksum="5113D9906B7923F8" modified="2021-04-07" version="1">MARRYDCNDATDRTTGLREAASAIRRGELVVLPTDTVYGIGADAFSSEGVADLLDAKGRGRNMPTPVLIGSPNTLHGLVTDFSEQAWELVDAFWPGALTLVARHQPSLQWDLGDTRGTVAIRMPLHPVAIELLTEVGPMAVSSANLTGHPSPEDCDAAQGMLGDSVSVYLDGGPTPGIVPSSIVDVTGGVPVLLRAGALSVEELRKVVPDLEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQH9</accession>
    <name>A0A7K2ZQH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_35910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001632">
        <property type="protein sequence ID" value="MYW34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="12918" checksum="DCE8DC68D7E52021" modified="2021-04-07" version="1">MAGAEAPEGSASPSPSRSASVEVSGSTAPMAGREAGAGKARPGRSLTPLELARAETPVSPEPSDEPEESASDLPVFTPPPEAFSEPGAAGARALDAAAVRQVQQVSLGTGIALVGLGIAFLAFRLRRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQN9</accession>
    <name>A0A7K2ZQN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_36555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001668">
        <property type="protein sequence ID" value="MYW34645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="15083" checksum="79EE897714BB22AC" modified="2021-04-07" version="1" fragment="single">RAVRERPALAVALTAATTWSVVGGTSLGREARAIGGALAAGDLEVARERLPHLCGRDPHSLDGPRIARAVVESVAENTSDAVVGALVWGAIGGVPGLVGFRAVNTLDAMVGHKSPRYRRYGWASARLDDVAGWPGARLTAALAVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQV5</accession>
    <name>A0A7K2ZQV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpsN</name>
        <name evidence="5" type="ORF">GT040_37120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001683">
        <property type="protein sequence ID" value="MYW34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="101" mass="11475" checksum="7A0AFD17D3DEC910" modified="2021-04-07" version="1">MAKKSKIAQNEKRKVIVERYAARRAELKEIVRSPGTLAAERDAALAELRRQPRDASATRVRNRDSVDGRPRGYLRTFGLSRVRMREQAHAGFLPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQX1</accession>
    <name>A0A7K2ZQX1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">recN</name>
        <name evidence="10" type="ORF">GT040_36780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001678">
        <property type="protein sequence ID" value="MYW34688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="17"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="581" mass="60433" checksum="8FC28D6561E25F19" modified="2021-04-07" version="1">MSVLEEMRIRSLGVIDDAVVELSPGFTAVTGETGAGKTMVVTSLGLLLGGRADPTLVRVGAKAAVVEGRITVSEGDAAALRAEEAGAELDDGALLISRTVSAEGRSRAHLGGRSVPVGVLTELADELVAVHGQTDQQGLLKPARQRGALDRYAGDGVEVPHAKYAAAYRRLRAVATELDELTTRARERAQEADLLRFGLNEVAAVEPLPGEDTELAAEAQRLGHAEALASAASLAHTALAGNPEDPEGVDATTVVAAAGQSLDAVRAHDPALAALADRIGEISILIADVSGELAGYADQLEADPLRLAAVEERRAALTTLTRKYGEDIAAVLAWAQEGAGRLTELEGDDERIGELTAERDALRSELSALGQALTDARTEAAARFAEAVTEELASLAMPHARLSFAIRQTEAADEASGIDIGGRSVVYGPSGADEVELLLAPHPGAQPRPIAKGASGGELSRVMLAVEVVFAGSDPVPTYLFDEVDAGVGGKAAVEVGRRLAKLARSAQVVVVTHLPQVAAFADRQLLVEKTVNGSVTRSGVTVLEGEDRVRELSRMLAGQEDSETARAHAEELLATARKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR34</accession>
    <name>A0A7K2ZR34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stp1/IreP family PP2C-type Ser/Thr phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_37155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001684">
        <property type="protein sequence ID" value="MYW34758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="482" mass="51287" checksum="DBA6E3D2F9D1C7E4" modified="2021-04-07" version="1">MSLSLRFAAGSHKGMIREGNEDSGYAGPRLLAIADGMGGQAAGEVASSEVISTLVQLDDDVPGSDILTSLATAVQQANDQLRVMVEEDPQLEGMGTTLTALLWTGQRLGLVHVGDSRAYLLRDGVLTQITQDHTWVQRLVDEGRITEEEATTHPQRSLLMRALGSGDHVEPDLSIREVRAGDRYLICSDGLSGVVSHQTMEETLASYQGPQETIQELIQLALRGGGPDNITCIVADVLDVDNNDTLAGRLNDTPVVVGAVAENQAVLNDSGAMQTPAGRAAGLGRPVPPPSGGFGPPGSGDSGYGSMPDGSYDSYTDDDLAKPRGGRKWLKRSVFTVLILGVIGGGLYGGYRWTQTQFYVGAQNENVALFRGISQDLAWISLSEVEKNHPEIELKYLPPYQRKQVEATIAEGSITDARKKVDELAAQASACKKDAQRRAAEAEAENSATPPTTGTKPNTATPTPGPSLSEEEKKLVPQCGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRF1</accession>
    <name>A0A7K2ZRF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AfsR/SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_37720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001705">
        <property type="protein sequence ID" value="MYW34868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="670" mass="72263" checksum="B2BA45A680DF8CD2" modified="2021-04-07" version="1" fragment="single">VVGAVLGVRDDAGPGGGAPLSAVDRLARALGDEPALLVLDNCEHVVEDAAELAERLLKAAPRLRILATSRKPLGITGEHLQEVPPLRHPGPAADPGPAADLGPAAVRRFSAVRLFEARAAAAAPRFVLDRSNVAAVVSICRRLDGIPLALEMAATRVRSLGVAGLEARLDDRFPLLATGSRSAPERQRTLRSVIDWSWGLLDEEERAVLRRLAVHSDGAALDAAEVVCGAGGPDRAPVVDLLARLVDCSLVVMAEGTDGPRYRLLESVAAYCTERLREKGEFDEVRRLHRAYYTELAERADPHLRGHGQRQWLCRMDAETANLRAALDSAVQDGDADRALRLVNAVAWYWRLRGRNQEAERSLALALSVADEAGPPGPEGTDARALSVARATAWLGGFRLAVHGSTDPRAVYEAALRPYAAVDDPAGRARSQWFLASHLYGIRDLAPSTELVARALDGFRSLGDRWGMAAALDSRTYHGMLRGDFGAVRRDGEQSLALFRDLGDQWGQLQAMVPLQTLAEAAGDYAYAGRLYRDGLRMAEGLGLWRDVAFQLSGLGRLALLTGDLPGARELHERARRLAAEQSDTFGEQYAETGLGLGARRAGELDAAEAHLRHVLELHRRMGYEPETPPLILAELGFVAELRGDAGEALRLQRKGLAVARATGDPRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRI9</accession>
    <name>A0A7K2ZRI9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ORF">GT040_38330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="WWKE01001735">
        <property type="protein sequence ID" value="MYW34984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="49"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MYW34984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="30547" checksum="F7F5D4557A951C0C" modified="2021-04-07" version="1">MLRIAVPNKGALSGSAMAMLHEAGYQQRQESKELVLVDPANEVEFFYLRPRDIAIYVSSGKLDIGITGRDLLLDSAADAEEILQLGFARSTFRYATKPGTATGPQDFDGMTIATSYEGIVAAHLKESGVKASIVHLDGAVETAIELGVAQIIADVVETGTSMRNAGLEVIGDPIMTSEAVVIRRNGAPTDDPKVQQFLRRLQGVLVARSYVMMDYDCRVEHLERAVALTPGLESPTISPLHHEGWVAVRSMVAAKEAQRIMDDLYELGARAILTTAIHACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRU5</accession>
    <name>A0A7K2ZRU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_39005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001774">
        <property type="protein sequence ID" value="MYW35111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW35111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="278" mass="29225" checksum="0857E013BB3C6F3F" modified="2021-04-07" version="1">PAGPLGLRLRGVRFGYGSAPVLDGLDLTVRPGETVALVGASGAGKSSVAHLLARYWDPQEGTVELVPQGPAHPVDLRDLAEDDLRAAVCVVGQEAPLFHGTLAENLRLGAPDATDHEMAATIRTCGLTPVTDALPHGLDTPVGERGTTLSGGQRARVALARGLLGRPRVLVLDETTAHLDHQGDAELARALAADSRARSRTTLIIAHRPATVRRADRIAVLDGGRIVEEGTWDELTRAGGALTGLLSRKSREETEAPEGTRPWAPVEAETTEAPAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS23</accession>
    <name>A0A7K2ZS23_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Malate synthase</fullName>
            <ecNumber evidence="2 7">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_39400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 7"/>
    <dbReference type="EMBL" id="WWKE01001787">
        <property type="protein sequence ID" value="MYW35184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW35184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="539" mass="60087" checksum="6027F36D613D076E" modified="2021-04-07" version="1">MSAPAPSTLAIVDAEPLPRQEEVLTDAALAFVAELHRQFTPRRNELLARRTERRAEIARTSTLDFLPETAAVRADDSWKVAPAPAALNDRRVEITGPTDRKMTINALNSGARIWLADFEDASAPTWENVILGQLNLTDAYERRIDFTDPKSGKSYALKPADELATVVTRPRGWHLDERHLQLDGTPVPGALVDFGLYFFHNAQRLIDLGKGPYFYLPKTESHLEARLWNDIFVFAQDYVGIPQGTVRATVLIETITAAYEMEEILYELRDHASGLNAGRWDYLFSIVKNFRDGGAKFVLPDRNAVTMTAPFMRAYTELLVRTCHKRGAHAIGGMAAFIPSRRDAEVNKVAFEKVKADKDREANDGFDGSWVAHPDLVPIALASFDAVLGEKPNQKDRLREDVSVAAGDLIAIDTLDAKPTYEGLRNAVAVGIRYIEAWLRGLGAVAIFNLMEDAATAEISRSQIWQWINADVVFENGEHATAELARKVAAEELASIREEIGEETFTAGKWQQAHDLLLQVSLDQDYADFLTLPAYEQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZS50</accession>
    <name>A0A7K2ZS50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent succinic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_39040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001775">
        <property type="protein sequence ID" value="MYW35118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="3"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW35118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="470" mass="50439" checksum="07E2ED1B6298BD4E" modified="2021-04-07" version="1">MPIATVNPANGELIRSYDALGEEETERRITAAHTTFQQYRTTPFEQRAAWLNRAADLLEADRDTIARTMTLEMGKPVTAARAEAAKCAKAMRWYAANAERLLADEHPDPADVTDSGASRALVRYRPLGVVLAVMPWNFPLWQVVRFAAPALMAGNVGLLKHASNVPQTALYLEDLFHRAGFPAGCFRTLLIGSGAVDAVLRDPRVAAATLTGSEPAGRAVASTAGDEVKKTVLELGGSDPYVVLPSADVEKAAATAVTARVQNNGQSCIAAKRFIVHAEVYDTFAEHFTAGMRALTVGDPLEESTDIGPLSSEQGRTDLEELVDDAVELGATVLCGGGRPDKLGGGLENGWFYNPTVLAGITPAMRIHREETFGPVATLYRVADLDEAVHLANDTPFGLSSNVWTRDAGEQERCARDLEAGGVFFNGMTASHPALPFGGIKRSGYGRELAGHGIREFCNATTLWYGPERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSK0</accession>
    <name>A0A7K2ZSK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3159 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001837">
        <property type="protein sequence ID" value="MYW35360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="253" mass="26564" checksum="D48364EFC61F4D23" modified="2021-04-07" version="1">MAIDQTHQQLHDGRPAPDPAEGRSATDPRDPAEAGTGLPGQPERAPRPRPTALEQAGGVRGVIYSALPVLAFVIGNAIGGLTTAIIAALALAVVIAAERLIRKESVMPAVGGVFGVAIAAGISWWTGSAKDYFLIGIWSNLALALIFGLSVLAGRPLAGVLWFSLRGKSSTWRDDRRARRYFGVATIVLTAIFAARFAVQQYLYQADEVGSLGTAKIVMGYPLLAVGVLAVAWAARAASRRSPEAGEAASRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSK7</accession>
    <name>A0A7K2ZSK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001839">
        <property type="protein sequence ID" value="MYW35370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="116" mass="12363" checksum="05E9FED88869424E" modified="2021-04-07" version="1" fragment="single">MKQDLRRQHLGRQDLKPAHLSPRDILRVGAVGLRARRTRVALSALGIAIGIATMVAVVGLSESSRADLMARLDRLGTNLLTAEAGEDATGRPVQLPRSAVAMVERIGPVRHATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5U7</accession>
    <name>A0A7K2Z5U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family deazaflavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000002">
        <property type="protein sequence ID" value="MYW27716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="153" mass="17145" checksum="2FE6A65F707E794C" modified="2021-04-07" version="1">MSQQPQPYYLRAGATATRLNNVIGRLARHGISLMGSAEMSVRGRTSGRMQRIPVNPHSYEGTQYLVSARGHSQWVRNMRVAGGGELRVGRRTRVFTAVEIADDAQKARILRAYLKRWGWEVNQYFQGVTAKSTDAELLAAGPDHPVFRITFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z636</accession>
    <name>A0A7K2Z636_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000018">
        <property type="protein sequence ID" value="MYW27810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="344" mass="37025" checksum="A5FAF5AB161A8583" modified="2021-04-07" version="1">MTSHVRHITVGCADAHALGSFWSKVLGAPLADDDFPGDPEALLETPGAAILFVQGPDAKTVRNRVHLDIQPQDRTRDEEVERLLTLGATLLEDHRKANGRGWAVLADPEGNEFCVECSAAERAALTGTRLPVTADDVTTAVRLAVDTLAGAPTDRWEALAGTLEWTCWETVEHLGDDLVSYAVRLGPRTPPLERNLPLRWTSERPGGPYSLLFADRAAGPAGLLATLEASGALLASMVRTTPPEVRAYHVYGVSDPEGFAAMGVVETLVHTHDLAVGLGLAWAPPTALCDRVLARLFPGAPAGGDRWTVLLWATGRAELPDHPRRTQWRWDGRPLEDQTVSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6A0</accession>
    <name>A0A7K2Z6A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_00870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000034">
        <property type="protein sequence ID" value="MYW27858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="130"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW27858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="270" mass="29537" checksum="450E77F1703DCF06" modified="2021-04-07" version="1">MLDELADDALRELAQRLAEQALHDGPAHPGAEQAAEPGADHGRVDPLARLRVLAHLGRAVSRQAQAEAEAAARAGANYPQLGAAWGISRQGARRRWPGLVFTAEPPSRPLPTRHHRSHDVNAFTTNRPYNVLLVEDDPADALLIEEALVDRGMARTIDQVTDGVAALQYLRDPGRERPDLIVLDLNMPRMNGRELLAVLKDDDALSNIPVVVLTTSSAPDDIEDAYRRHANAYVTKPVNLDAFIKSVQEIDAFFLDTAVLPPRSGNRDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6C3</accession>
    <name>A0A7K2Z6C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4255 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000051">
        <property type="protein sequence ID" value="MYW27886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="25" mass="2754" checksum="AAD49620F3589DA6" modified="2021-04-07" version="1">DAEGFAATRERQLPPGRRKRGSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6K1</accession>
    <name>A0A7K2Z6K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S9 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000063">
        <property type="protein sequence ID" value="MYW27977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="87" mass="9288" checksum="4C5B3CEDD761E235" modified="2021-04-07" version="1" fragment="single">MSGGIGTAVHVPFFAARDGRRAVETRYVDGLPQIVAWNLTTGQRRQVTTAPLGAETAAIEPDGHGLWWFDAAPGGQGRWLRGPFEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6S0</accession>
    <name>A0A7K2Z6S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000076">
        <property type="protein sequence ID" value="MYW28031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="10328" checksum="86CB72F496B6C544" modified="2021-04-07" version="1">MVTGSWIPLAGGWLIAYGSRTLSRTEAKWAALGLPGVVIAGALVWVWGRMDRRWGEPIEDGALREVLMGAWPVVVRIAAVASALYLVWRARRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z733</accession>
    <name>A0A7K2Z733_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-dextrin endo-1,6-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
            <ecNumber evidence="5">3.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pullulan 6-glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pulA</name>
        <name evidence="10" type="ORF">GT040_02450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic linkages in pullulan, amylopectin and glycogen, and in the alpha- and beta-limit dextrins of amylopectin and glycogen.</text>
            <dbReference type="EC" id="3.2.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EC" id="3.2.1.41" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000107">
        <property type="protein sequence ID" value="MYW28159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10315">
        <property type="entry name" value="CBM41_pullulanase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005323">
        <property type="entry name" value="CBM41_pullulanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011839">
        <property type="entry name" value="Pullul_strch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024561">
        <property type="entry name" value="Pullul_strch_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040671">
        <property type="entry name" value="Pullulanase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045041">
        <property type="entry name" value="Pullulanase_PULA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43631">
        <property type="entry name" value="PTHR43631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11852">
        <property type="entry name" value="DUF3372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03714">
        <property type="entry name" value="PUD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17967">
        <property type="entry name" value="Pullulanase_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02103">
        <property type="entry name" value="pullul_strch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029748442" description="Alpha-dextrin endo-1,6-alpha-glucosidase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="9">
        <location>
            <begin position="58"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW28159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1772" mass="192359" checksum="194D0919622EBE1A" modified="2021-04-07" version="1">MSRTTLRRGVIAALCVALLPVVPAATAAAAPRPPAPPSDAELAKEAARHDLTREQFYFVLPDRFANGTTANDRGGLKGSRLEHGFDPTDKGFYQGGDLKGLTQKLDYIKGLGTTAIWMAPIFKNRPVQGTGKDASAGYHGYWITDFTQVDPHFGTNADLEKLIDKAHAKGMKVFFDVITNHTADTVDYAEKTYGYKPKGAFPYLDEDGRPFDDRDGIKKVDRDSFPYTPVQAPGAEKKVPSWLNDPTMYHNRGDSTWAGESNEYGDFSGLDDLWTERPEVVKGMEKIYEKWVRDFDIDGFRIDTVKHVDLDFWTQWATALDAYAAKRGRDDFFMFGEVYSADPAITSPYVTRGRLDSTLDFPFQEAARQFASQGASADRLASVYGNDYRYTTDKANAYEQVTFLGNHDMGRIGTFLKQDNPQADDAELLKRARLANELMFLGRGNPVIYYGDEQGFTGAGGDKDSRQTLFASKTADYLDDDQLGTDRTHASDAYDTKHPIYRSIAGLAKLTEEHPALRDGVQSERYAEGSVYATSRIDAKRPYEYLVASNNAATPKKVELSTESAGVDFRTIYGGSGAVRSGADKKVTVTVPALSSIVLRAEKQLGSPAAKPAIALKAPAAGATGTVEITADVDGGQLNRVVFAAQVGNGKWQKLGSADHAPYKVTQYLDETVKAGTPLRYKAVVVDRAGRTSSALAATTAGQTPPTPKPVAIERDRAVVHYRRADGDYEGWQLKSADKTAEFIGRDAYGAFAWIDLEKGTDSVPYTVEKNGTADGPRRTIDLGVTGQVWIEQGKDEQAVEAPEAPPQDTTKAVLNYHRADGNYDGWGLHTWTGAKEPTDWAKPLMPVKKNAYGVTFEVPLVDGATSLSYILHKGDEKDLPSDQSLDLATYGHEVWMLGSKPGYLLPQVGGGAAPDLTKAEAQWIDADTVVWKVKTTDATSQQLVYAKKGGISVVGGALSDEGQWLRLTSAALSDAQKAKFPHLKDYPAFTVDPRDRDRVVQSLRGQLIATQRAANGALLAATGVQTAGVLDDLYGKKAATAELGPVFRKSVPTLSVWAPTAQAVALELDGRTHRMKRDDRTGVWSVTGKKDWRGKPYRYAVTVWAPTVHKLVTNKVTDPYSTALTADSARSLVVDLTDPKLAPSGWSGLKKPAATPLRDAQIQELHVRDFSITDRTSTHPGEYLAFTDTRSKGMRHLKKLADSGTSYVHLLPVFDIGTIPEKKKDQAKPACDLHVHAPDSEEQQACVSKAAAKDGFNWGYDPFHYTVPEGSYASDPDGTKRTVEFRQMVQGLNQAGLRTVMDVVYNHTVASGQDDKSVLDRIVPGYYQRLLEDGTVATSTCCANTAPENAMMGKLVVDSIVTWAKEYKVDGFRFDLMGHHPKDNILEVRKALDRLTPAKDGVDGKKIILYGEGWNFGEIADDARFVQATQKNMAGTGIATFSDRARDAVRGGGPFDEDPGVQGFATGLYTDPNSSPANGTRAEQRARLLHYQDLIKVGLSGNLADYTFTDTSGRTVKGSDVDYNGAPAGYAAVPGDALAYSDAHDNETLFDTLAFKLPAGTSAAERSRAQVVALAASVLSQGPSLSQAGTDLLRSKSLDRNSYDSGDWFNALHWDCRDGNGFGRGLPPAADNQDKWPYAKPLLTASATIAPKCAQIDGASAAYRDLLTIRTTEKEFSLSTTGQVQSALSFPLSGTDETPGVITMRLGKLAVVLNATPDTATQRLAAPAGKTYALHPVQTKGADLTVKRARYDGKSASFTVPGRTAAVFVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7F2</accession>
    <name>A0A7K2Z7F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000125">
        <property type="protein sequence ID" value="MYW28243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="225" mass="23711" checksum="0149FC0F75D793C2" modified="2021-04-07" version="1">GAWLTGDSSAEPTRTPYTAGRTVWHSVPVDTLFPRTLKGTGAGPGGTNRTWTRLAVAADGDCAKGLDPLLRTTLRSVGCERMVRATYTDSTRSAVTTVGMVVTEADAAGMQALSVRFTEQKLAARKDLMPRTYAPEGTVAAGFGDRQRASWTVRPLTEIPVVVFAVSGFADARTVAEPQPADAATETPATTDIAQAGLGHEARGIADRVERGLRTTVTDLVEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7G5</accession>
    <name>A0A7K2Z7G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000135">
        <property type="protein sequence ID" value="MYW28262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13218" checksum="30A112BBBB973FA7" modified="2021-04-07" version="1">HSTALGKVLLAWSRPGEGGPESLPPLPAFTDRTIVEPEALEAELVRVRAAAYALNDGESAHGVRTLAVPVLDGAGYARFALAVRATPSLITAERTEWLLTEARSCARALEVLLLSPAERRPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7I2</accession>
    <name>A0A7K2Z7I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_03025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000143">
        <property type="protein sequence ID" value="MYW28272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="324" mass="34370" checksum="5B93D8A3D09E4B09" modified="2021-04-07" version="1">MRVTIADVAREAGVSKTTVSRVINTKGEVDGSTAARVREVIAQLGYVPSSGAVGLARGSSRTVGMLVPSLTWPWMGELLQGVVDTVEAADYGLLLFTCNRGSESVQRFTTQVTARAFDGLVVVEPENTLGHLTALHRDGLPIVLIDDRGHHPEFPSVVTTNHEGGASAARHLLAAGRSRPVVLTGPQHFGCVRDRLGGFRSALPDVRVVEGDFTELGGRLAMEELLARGVAFDSVFAHNDISAAGVLRALRAAGRRVPDDVAVVGFDDIPMAEHTEPPLTTVRQPTRRMGETAARMLLSHLGGTPVPDGPAVLPTELVVRHSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7P7</accession>
    <name>A0A7K2Z7P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="64" mass="6951" checksum="0F3EAD0EC732B4FC" modified="2021-04-07" version="1">MTTIHTIDTANAPALGDIRAAGEEAVIRVRRSATERKDFARYWEAVGVALVRGAVVDVINREGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7Q9</accession>
    <name>A0A7K2Z7Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metalloregulator ArsR/SmtB family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_03590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000149">
        <property type="protein sequence ID" value="MYW28376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="128" mass="13446" checksum="F39D6A9F9FF9574A" modified="2021-04-07" version="1">MEPPSAAPGPGPAPAPATAAASDDEASAFRALADPTRRQILEDLRGGELAAGEIASRFSISAPSISRHLGVLKGAGLVTERRDANRILYSLAEERLAMCVGRFLSAVCPEQIVLRHTKWRSAPEGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7T1</accession>
    <name>A0A7K2Z7T1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_03620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000150">
        <property type="protein sequence ID" value="MYW28382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="228" mass="24136" checksum="8BB3B267BE2BBB73" modified="2021-04-07" version="1">MIPEGSLLAAHDLRKTYGATPALDGASFSVHPGEVVAVMGPSGSGKSTLLHCLAGIITPDSGTITYAGRELSAMSDAERSALRRSDFGFVFQFGQLVPELTCVENVALPLRLNGAKRKAAERTAREWMERLEVEDLGAKRPGEVSGGQGQRVAVARALAGSPKVIFADEPTGALDSLNGERVMELLTEAARSSNAAVVLVTHEARVAAYSDRDVTVRDGRARDLEHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7V3</accession>
    <name>A0A7K2Z7V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_03815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000159">
        <property type="protein sequence ID" value="MYW28421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="154"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="349" mass="35200" checksum="5A96D66637FD4023" modified="2021-04-07" version="1">MHASRGTQKRSAGLGLALLSAFAFGGSGVAAKPLIEAGLDPLHVVWLRVAGAALIMLPVAWRHRNLVRERPALLAGFGLFAVAGVQACYFAAISRIPVGVALLVEYLAPALVLGWVRFVQRRPVTRAAALGVVLAVGGLACVVEVWAGLSFDALGLLLALGAACCQVGYFVLSDHGGQEAKGRDGREGEGGDGGSVEPPPPLGVIAYGLVVGALVLTVVARPWGMDWSLLGGTAGMNGTGVPAWVLLGWIVLIATVLAYGTGVVSVRMLSPQVAGVVACLEAVIATVLAWVLLGEHLSAPQLIGGFVVLTGAFIAQSSAPKPPSGPVAAGAGAAAAAAESELSAGRASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7X0</accession>
    <name>A0A7K2Z7X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_03865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000162">
        <property type="protein sequence ID" value="MYW28431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="9"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="182" mass="19306" checksum="87BC1B39A478A547" modified="2021-04-07" version="1" fragment="single">MMTHAAYCDVLVIGGGIVGLSTAYALQRAAPGTRVTVLEKERGPARHQTGRNSGVIHSGIYYRPGSLKARYALRGSAELADFCAEHAIAHATTGKLIVATERSELPRLHSLVQRGREHGLPVRELGPAQIAEYEPEVRGLAAIRVGTTGVCDFSAVATRFATEVTAAGGIVRYGAEVTAIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z842</accession>
    <name>A0A7K2Z842_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000197">
        <property type="protein sequence ID" value="MYW28516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="321" mass="35991" checksum="705159F0774152B2" modified="2021-04-07" version="1">MPKLSVVVPFHNVGAYAGTTLSSLARNADQDMEFLLVDDASTDGTADVVDHWAGRLPGARVITHRTNVGIAAARNSGIDAARGDFLTFLDGDDWYAPGHLGRLLRAAQELDCDFARTDHVQSTGTSRVVRRAPAPLRDTVLDPREGIGVPERETMVDYPFVWAGIYHRRLFADGAQRFATELRTAEDRLWIWQLHLRARTYAALGLYGVFYRRGVATSLTQIKDDRQLDFFPAYDALLGLLREDRDAERLLPKAVRTYCAMIAFHNEKADAYEPATARRLRGQSTAALHRMPQEVLDRTLTMIDDKRGVLLSRLRNKQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z899</accession>
    <name>A0A7K2Z899_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_04670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000205">
        <property type="protein sequence ID" value="MYW28577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW28577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="97" mass="10202" checksum="0EABF1A819EB9D1D" modified="2021-04-07" version="1">MPVPAHPRSHRPAASSHRPAVSSYRSAASPRPVPAPASPRPAADRGEIRLPWWAVVLPAVAFAALLFMIMSPGQAQAATADPALGQLIEYALHLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8H7</accession>
    <name>A0A7K2Z8H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_05030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000221">
        <property type="protein sequence ID" value="MYW28646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW28646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="106" mass="11505" checksum="D70A3C93BF14AC66" modified="2021-04-07" version="1">EREATGDPTAHAEILALRRAAEAVGEWRLTGCTLVVTLEPCTMCAGALVQSRVARVVYGARDVKAGAAGSLWDVIRDRRLNHRPEVIAGVLEDDCATRLTAFFRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9H4</accession>
    <name>A0A7K2Z9H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_06770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000304">
        <property type="protein sequence ID" value="MYW28984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="217" mass="23793" checksum="F1C0029DA54676F6" modified="2021-04-07" version="1">MRVLVAEDEEILAELVATGLRRAGFAVDTVYSGDAALAYLGLHDYDVVVLDRDLPRVHGDDVARRLVASGSRTRILMLTASGSMEDRVAGLDLGADDYVSKPFEFPELVSRVRALRRRSARPVPPQLERHGIRLDTVRRSALRDGRDLDLSPKEFTVLQLLLEADGGTVSAEELLERAWDANADPFTGAVRVCMSKLRAKLGEPALIRTVQGVGYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Q4</accession>
    <name>A0A7K2Z9Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inositol phosphorylceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_07160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000321">
        <property type="protein sequence ID" value="MYW29058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="56"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="28331" checksum="06A0E8FFC914B0E6" modified="2021-04-07" version="1" fragment="single">MTYARTEPTDQEPDIRARPPLVREFLLVAGLFLAYKFGRRAANGHVEEAFRNAGNVWDLERALHLPGEGAVQGVLLHSQTLIHAANTYYATVHFPATALFLVWLYWRRPLHYLWSRRILAVLTGGALVLHLLFPLAPPRMLPAAGLVDTGQVYGPTVYGATPATDTMANQFAAMPSLHVGWAVMVAVGLIVATRSRWRWLWLLHPAITLLVVVGTANHYWLDAIVVVALLAVALAALRLPRAARNVPAHLPWAADGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9V5</accession>
    <name>A0A7K2Z9V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_07565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000355">
        <property type="protein sequence ID" value="MYW29137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CR-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="277" mass="28300" checksum="D58F131BF5DB2D2A" modified="2021-04-07" version="1">GGGGLGDVFGGLFNRGSTGTRVQPRRGQDIESEVTLSFTEAVDGATVPLRMSSQAPCKACSGTGDKNGTPRVCPTCVGTGQVSRGTGGGFSLTDPCVDCKGRGLIAQDPCDVCHGSGRAKSARTMQVRIPAGVSDGQRIRLRGKGGPGERGGPAGDLYVVVHVGAHPVFGRKGDNLTVTVPVTFAEATLGGEVKVPTLGGPPVTLKLPPGTPNGRTMRARGKGAVRKDGTRGDLLVTVEVAVPTDLGQEARDALDAYRKATADEDPRAELFQAAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Y5</accession>
    <name>A0A7K2Z9Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_07720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000358">
        <property type="protein sequence ID" value="MYW29167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="151" mass="16127" checksum="200BDD779F574874" modified="2021-04-07" version="1" fragment="single">MDTAVGKERGRGALLGLAVGDALGAPAENLRPSEIRRRWGRIEGFVSEDPAGTDDTEYAIFSGLLLARHGSALTVSHVERAWHHWIADLDEGPFRGAGFSERGTLENLRRGLAAPISAQHRHAWSDGLAMRAAPFGVFAAGHPAEAARLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZA21</accession>
    <name>A0A7K2ZA21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_07800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000360">
        <property type="protein sequence ID" value="MYW29183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW29183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="107" mass="10494" checksum="54E31FDC33C5D4CE" modified="2021-04-07" version="1">MTAETEPTTQSTGSCCSPSGSCHGGGAADVQIEPTDSVTTVYEVKGMTCGHCEGAVSEEISALGGVTSVEAVAATGRVTVSSKAPLAEGAVRAAVDEAGYELVGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAA0</accession>
    <name>A0A7K2ZAA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_07860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01000361">
        <property type="protein sequence ID" value="MYW29195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029802110" description="Phospholipase C" evidence="6">
        <location>
            <begin position="43"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="500" mass="54762" checksum="27513BA0DB805AD2" modified="2021-04-07" version="1" fragment="single">MTTDMSRRRLFALGGGALGAAAAGSFLPPSLQAAIAAQPAHAGSGGGGLGAIKHVVILMQENRSFDHYFGSLRGVRGFGDRNAIELPAGGTVFEQPGPSGATVLPFPVRGAAEEQKKDLQYIGALDHSWNGGAKAWGGGWMNGWISAKTAATMAYYDRRDIPLHYELADTFTVCDAYHSSIHTSTSPNRNHLWSGKTGYEPNGKRAVGNDAYNEGSHPGYDWSTYAERLEKAGRSWRTYTEWENFTDNQIEFYATFKAIARKALAQTGGPTYMEAFYAKVRDASATERTRLLGLLEEGVATLTKQERSLFERGLRRVPTGTLADEFAKDVAAGRLPEVSYLVPSAIDSEHPSVSSPVHSATIVYKILDALGKHPDVWRHTAVLINYDENDGFFDHVPPPVAPPEVTDEQWEGRPTGLGIRVPLLVVSPWTVGGYVCSEVFDHTSVIRFLERWTGVKEPNISDWRRRVTGDLTSAFDFTRARRQPAVQVPGAIPPLTGRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAG9</accession>
    <name>A0A7K2ZAG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000402">
        <property type="protein sequence ID" value="MYW29329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029812432" evidence="1">
        <location>
            <begin position="32"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="443" mass="48116" checksum="67604E8D01F162AC" modified="2021-04-07" version="1">MRTSRLTTTAVAVAAISVLATACTGQSEAGATDDPKAKTTINFWHGWSSPAEVKAVQDNIDRFEKAHPNITVKVSGNINDDKLNQALRAGGSNGPDVVSSFTTANVGKFCSSGAFADLGPFIGKSDLDLEKTFPKVLLDYTQFEGKRCALPLLTDAYGLYYNKDAFKKAGITAPPKTMSELASVAKKLTVEKGDSYQQLGFMPNFHGYETVADHYLSSWDHKYFDENGKSNIAKDPAFAEMFTYQKKLVEDLGGYAKLEKYRGTFGDEWGAKHPFHTGQVAMQLDGEWRLGMAEDAGAGFEIGVAPMPVADDEADSYGKGFLSGTIVGIAPASKKQNAAWELVKYMTSDTEAVVNFANGIRNVPSTFEALKSPGLKFDPRFKTFLDIAQHPRSSTPDGAVNGSTYQQTLQDFGYQYEKDAVKDLQAGLEKTAKQIDTDIAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAH5</accession>
    <name>A0A7K2ZAH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="185" mass="19782" checksum="9DCD8707D4EE9399" modified="2021-04-07" version="1">MSTASTAGDLPALLLAWDTSPLFHAIKAGKLDVLGDIAQTWQGVSRRNVTTQTVVDELGTYGLSLASADWLEIVHVDHLNELTALVKWMDLVSGSKSNQGEATVLAWAEVNGAIAVIDDGDARRIARRHSLPVWGSLRVIATAVSEGNATEYVAGTLVDALIDTDARYPCARGQFVSWAKQNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAI4</accession>
    <name>A0A7K2ZAI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SHOCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_08830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000406">
        <property type="protein sequence ID" value="MYW29381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="8">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="7">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW29381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="15325" checksum="BA1E458F1788D32B" modified="2021-04-07" version="1">MDDYPLLNLFLTMLYLFLWVMWFFLLFKVITDLFRDHTLNGWAKAGWLIFVIVLPYLGVLIYLIVRGRSMHERDAKAVKESEAAFRSYVREAASSEGSSGSTSHVSDLTKLAELKDKGALNAEEYERAKAKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAK3</accession>
    <name>A0A7K2ZAK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_08585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000402">
        <property type="protein sequence ID" value="MYW29332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1878"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="2122" mass="226176" checksum="2B1899C37FF0C6EA" modified="2021-04-07" version="1">MAQAAEGPGRPGVPKQRASKVEPMSATGAAEVRRNAERSAARNAAEAGRAGGERGASSWPASATAEIPSAASGKGSPTRVGRVPVTVERVRGTASPAEVDVAVLDRKDTAAASVSGVILTARGDRPGTAEVTVDYSSFASMIGGGWAGRLSLAQLPACALTTPGAAGCREATPLDTRNDVKGQQLTAEVSFPAGSAAKAGKQAAPVVLAVAATGSGQSASGGGDFSATPLASSAGWEAGGSSGSFTWSYPMGAPAPAAGPQPSLDLSYDSGSIDGRNSSTNNQATDVGEGFGLSTGSYIDRQYGSCAKDGHAKQYDLCWKYDNASLVLNGKSSELVKDDTSGKWRLSNDDASQVTRLTGADNGDDDGESWIVTTADGTKYHFGVDRLLGAGSQRTNSVWTAPVFGDDQDEPGHDKGDTFAKRSLTQAWRWNLDYVEDIHGNVMTYWYTKEENHYRKNRADTADTAYTRGGHLDRILYGQRGDTLFSATAPYRVSFEHKERCTASDCDKLTESTAKNWPDVPFDAICAAGANKDKCLAEGPSFFSRKRLTKITTGVLAGSDYTPVDSWAFDQTYLDGGDIGNSSDHVLSLRSIRRTGHTGTAITPDPVGFTYHMRPNRVEGGTQPGGGNILPLTRPRLNTITSETGALTTVTYSAPECVRGSRMPAAEDDNAEPCYPLYWNINGATEASLDWYHKYRVLAVTVGDPAGHGETVEHSYVYEKPAWHYNNSPFVPSDERTWSSWRGYQKVTALAGAATGTRTKTVSTFLQGMHKDPRATGGPRTVTVPGIDVAGLDVPDVTDSEQYAGFARQTITYDGDTPVSVTVNDPWSVRTATQHKSHADTEAYYVRTGRATTHTYLTRSKTWRSTSTATTYDSYGMAERIDSTGDLAKSGDETCTRTWYARNDTLGLSDLTSRIRVVGRPCATGEAALSLPASSATRGDVLADTATVYDTPSPTGWAASQKPTRGTETWTGRATGYPATATGGERDPRGWQRTSASTYDALGRPLIVTDAAGQPTSTVYTPTGAGVPARATVTNAKGHRTITVLDGVRGLAVQTHDANSLKTEQSYDALGRLRQVWLPDRSSSAGQSPSISYSYTLQRGKAPAIGTSTIKSSSTVSTSYEIFDSLLRPLQKQTPTSNGGRLLTDTRYDSRGLVRQTLSEVFDSKSTPNAEYARAEFGGAPKQNDFVLDGAGREISNTFAVFGIDKWTTTKSYTGDSTATSAPAGGRATRVITDALGRTVQRREYAAPQPTDIEYTGTAGAAYTTTRFGYTTDGKESSITGPDNSRWTSTYDLFGRKVASTDPDKGAASTGYTAADRPDWAEDAEGRRLLYKYDELGRTTDLWAGARTDANKLAHWTFDTLAKGQLTSSVRYEGGAVDTGRAYTKAVTAYDSRYRATASQISLDAKDPLVVSGAAQSSYAFETAYNLDGTVQYTSEPTAGGLPAERVAMTYTSTGQTASVASGTSGYLHSASYDVLGRPLQLTLAVSGAAEAKKTYLNNEYEEGTGRITRAYVTTPQTAPYKPQDLGYTYNQAGNVTRITDTPNPDAVLKGETQCFSYDGHSRLNEARTSTTTDCSSSTPGGPAPYWTAYTYDEGGQRRTETQYDVNGTGTTSTFCYTDTARPHALKATTKATGEKPCDAATPAYDYDKTGNTTKRPGPTAGQSLLWDAEGRLTQLTEGARRTNYLYDADGTLLIRRATGDGESVLYLGGTEIHLKVTGSTRTSWATRSYKADGTVIAVRSNESGSQRLTFLAGDNHGTSSLAIDATTQAVVRRYTTPFGAARGTGPGNWPDDKRFLGKPADTGTGLTHIGARQFDALLGRFLSVDPLLESDKHQSLNGYSYAENNPVTLADPTGLGSFSCSGKSCSPDVIAAEETVSPPVVGSGGPGGYGGPGSSGKSKGGTASGNTCGPQCRAAALYEQQRVMALRQARADQIRTLMYGMQPPQSRFLPKVDLRGCNKECRTELLRLHITNMPVTSGSSKNYNLIKWLNDVGAEGARDTAGFLGDIPRYESDAVGELYEASVILTGGSCKDDGADLTVCTHGLIPLSARGGTTLGDTYTTEKGVPEYVSPKRLRHEREHVKQWEKYGDNFIIKYFMEGLDPCGNKYEEQADYADGGYSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAW8</accession>
    <name>A0A7K2ZAW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_09225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000418">
        <property type="protein sequence ID" value="MYW29452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="210"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW29452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="326" mass="32951" checksum="DC5AB6A7152CED0F" modified="2021-04-07" version="1">MGRHRRSAAGPAAEEPAAGAASRHRGTRRKKKSAVPVRTGLLGASAAMAVGAVAVASGLLPGGDTYTSGGSTAADQVRTGGAPDLLTQQGGSSAPADRSSSPASRGSERPEAPPKPPSESPSTTPAKTPSKSPSSSASKTPSKSAAPSATPSKKPAATPSKESKAPTTAPRKSTAPASKAPAPPKKTVAPPPSKKPAPSPSDTSARAEVLALVNQERAKVGCSPLTTSTPLTSLAQNFSEDMAARGFFDHTDPDGDTPWDRAAQAGVQGLAAENIARGQADARAVMDGWMNSDGHRANILNCDYKTIGIGIHEGSGGPWWVQNFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB59</accession>
    <name>A0A7K2ZB59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class IV aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_09955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000457">
        <property type="protein sequence ID" value="MYW29590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="264" mass="28323" checksum="01FF847040CBFC4A" modified="2021-04-07" version="1">YVEMDGRPATEDDLRVPALFGFGHFTALQVRDRRVRGLGLHLERLEGANRELFQLPLDRGRVRELVRGALDRAGLRDASVRVHGFLPPGESRTRVMVTVREPAAMAPGGRSLMSVPYARAVPHIKRPGEFGQTYYGMLAARAGFDEALLTAPGGVVTEGAITNIGFWDGSSVVWPDAPALTGITMALLERGLAAAGEPSVRRAVTLDGLGAYRGAFICNSQGMAPVRRIDAVEFAGGGEAAREEMERVMGRLEAAYASAPAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB60</accession>
    <name>A0A7K2ZB60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000459">
        <property type="protein sequence ID" value="MYW29596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="56" mass="5854" checksum="9248F92EF418C79A" modified="2021-04-07" version="1" fragment="single">MHPHPPAAPARRLLPLVLPAIAVGIVCALVLLGVSLLAERLQDVLWETLPDALGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBD8</accession>
    <name>A0A7K2ZBD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000464">
        <property type="protein sequence ID" value="MYW29628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="384" mass="41607" checksum="EB3482FF3C662A7F" modified="2021-04-07" version="1">MSLTFHWFLPTNGDSRHVVGGGHGTPVTAAGGDRPPTVRYLAQIARAAEDVGFTGVLTPTGAWCEDAWLTTAMVSQHTERLKFLVAFRPGFISPTLAAQMASTYQRQTGGRLLLNVVTGGESHEQRAYGDFLDKDARYARTGEFLEIVRQLWDGKTVDLDGDHLHVEQARLTQLPDPVPEVYFGGSSPAAGRVAARQADVYLTWGEPPAQVAEKIAWIRSLAAERGRTVRFGIRLHVITRDTSEAAWAEADRLLAGFDPATVRSVQEGLRRSESEGQRRMLELHGGGRDGLEIHPNLWAGIGLVRGGAGTALVGGHAEVADRIREYHALGIDEFVLSGYPHLEEAYWFGEGVLPRLADAGLWTHPAGPVRPAGGTEIPFAGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBW9</accession>
    <name>A0A7K2ZBW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000500">
        <property type="protein sequence ID" value="MYW29808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="205" mass="21708" checksum="4DD0DA830CDFF5EC" modified="2021-04-07" version="1">RLAEAVDAARYAHGGATVTGETVDLFDLDAARDWAKRTEAEFGRIDGLVHLVGGWRGSPSFQETSLADWDTLEKLLIRTVQSTSLAFQEPLQRSDKGRYLLISAAGAGKPTAGNAAYSASKAAAEAWTLALGDAFRKAGGEDGPAAAAAILVVKALVNDAMRAERPNAKFAGFTDVKELAEAIAGVWDKPAPEVNGKRLWLTPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC85</accession>
    <name>A0A7K2ZC85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FxsB family radical SAM/SPASM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_11775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000546">
        <property type="protein sequence ID" value="MYW29943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026335">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04269">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="773" mass="82660" checksum="240E4B0BD836EAA0" modified="2021-04-07" version="1">MTGPAVPFREIVLKVHSRCDLACDHCYVYEHADQSWRTRPKTISDHVVSRTAQRLAEHARTHALPSVTVILHGGEPLLAGPARLRRVCEEFTSVLAGIAELDLRIHTNGLQLSPRYLDLFDEFDVKVGISLDGDRAANDRHRRYADGRSSHPLVLKAVELIRQDRYRHLDLGLLCTIDIANDPVAVLDALTGLEPPLIDFLLPHATWDDPPPRPDGSPTAYAEWLLTVFDRWQERGRPVPVRLFSSVLSTLSGGPSLTESLGLAPTDLVVVETDGQLEQVDSLKSAYEGAAATGFDVFTHSFDEVAAHPGVRARQLGLAGVSETCRRCPVVRSCGGGLYTHRYRSPGGFDNPSVYCADLTALIRGIEDRTAAATESPAVRDPDELLAAQQDLTRTLLAALHDGLDGSGGEAWETAWALAAEVESDPAGQTGLDVVLAHPYTRTWLLDALETVRAGRPVEGPPVERLAASVAAAAVHAGLDLTVPVAHRDGRLFLPTLGEVRAGGAGETGTALVRADGEGFTVHTGGGALHIARDEGEGPHWSPVRRLAAGGPGAVRAAGGPGPVPTLVLDDLDPYRSCFGAPAARRFSPSAADSWSASLAAAWELLAETVPEQAAEAAAVLTTLTPLTGGEAAQVGRHGYGALGIAAGGDTHTLATALLRGFRRTKLRALAEVTDLYASDGSWDHRMPWQEEREEPVPFSRLLAETYERVALGLFAPRFLAGVPQALDMIEEAAETTVDGKQLLAVMRKEINGTHGTSGRNGCKTDVERAAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCD3</accession>
    <name>A0A7K2ZCD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000553">
        <property type="protein sequence ID" value="MYW29993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="202" mass="19981" checksum="CAFBA14F5AF00B0C" modified="2021-04-07" version="1">MTAAEHRHGAAPGHKNVLCLVVSTGVGAGLVLNGSMRHGLTGNAGHLGHISIDFDGETCPCGARGCVEALASGTAIIRHALALGRQAPLTADAAGVAAAARTGEAAAIAAFDRAARALAADIAATAALIEIDIAVVGGGVAQSGEVFFERLARHLRCYAAMPFLKELRVVPAELGPDAGLVGAAVLASAGISPLATVLARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCT8</accession>
    <name>A0A7K2ZCT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_12940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000602">
        <property type="protein sequence ID" value="MYW30167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="942"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW30167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1370" mass="150651" checksum="E494D001772E6F7E" modified="2021-04-07" version="1">MAINDVDQTERDTAGEQSLPHLLLRQVRDHPDRTAVVQGDEHLSYRDLAAHSSAIADYLLNLGVVPDDSVGIFVEPSIELMTSIWGVLLAGGAYLPLSPEYPEERLRYMIEDSGVRVVIASEELRPRLSLLAPPGTRVISPAGAAAARTSAGPSPAWTVPADLTPAHLAYVIYTSGSTGKPKGVMIEQRGIVNQMRWLAESGVLDRSTTVLQKTPMSFDAAQWEILAPACGSTVVVGGPGLYRDPERIIDTVIRHQVTALQCVPTLLQALLDTDDFRTCTSLTRVFSGGEALSRNLAQKFVETLPGSALTNLYGPTETTVNASAFTVDRRTLAEGPQVISIGSPVRGTRFHILDKHRNPVGSGEVGELHIEGVQLARGYLNRPDLTAERFIEHTVDGEDVPVRLYRTGDLAHRDDDGAFHFAGRADNQIKLRGFRVELDEIRLAIETHDWVKNAAVLVKEDTSTGFQNLIACIELSPKEAALMDQGRHGAHHQSKESKLQVRAQLANPGVREDQDADGRVTVDLPGAVPTPEQRQLAFGRKTYRSFDGGDVTAADLLALLAGPDEPAGASRDVGALDLADLGELLRNLGQFISEERLLPKYAYASPGALYATQLYLEADGIPFLRPGFHYYHPVEHRLILISPKPETPGAAARIRLHFAGKRRAIEPVYKNNIAEVLEIEAGHMAGLFDRLLPAYGLGLATGAYEPATMDRLDCADEDFYLGTFEVLPLTAVRPGPPAEIYVQAHADKVAGLPEGQYRYRNGGLERISDALIHKRHVIAINQQVYERSSFGITVISRARETWLDYIDLGRALQHLQMNDLHIGLMSSGYSSKTGHDLPAAVRMTGILGALGEKAGASYFSVGGRISEGQLRSEGMREDIVHMKGPAEIVREDLSRFLPDYMMPNRVVVMDALPLSANGKIDAKALASSERIAAATTDRVFVAPRTRTEERVRDIWEKVMKRDGSSVHDDFFASGGNSLLAVGLVNRINREFGSSLPLQILFESPTVEKLALALESTDTEPASRLVRLHSESTGNPVFCWPGLGGYTMNLRSLAGELDIGRPFHGVQSYGINPGEIPYATIQEMAAADVRAIRRLQRTGPYTLWGYSFGARVAFEAAHQIEQAGGTVENLFLLAPGSPLIPQTNADPLAHGDDPVYANKAYVRILHSVFAGTITGEEADACVAYAEDDDSFTEFIRAERPDLDTELVKRIIQVVRRTFSLRYTFEELRERRIKAPVTIFKARGDDYSFIESSQGYSEVEPDVVELSSGHYTMLRSPGLKELVQQIRYRLSARNEETVVPHVNIKFFPVPLSEDQRSELVEAVTRAVKSAFRCDEGVISVALEPVEKEVWNERVYLPEIVQRKDLLHKTPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCU4</accession>
    <name>A0A7K2ZCU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_12740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000598">
        <property type="protein sequence ID" value="MYW30128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="224" mass="23800" checksum="D09536438480670F" modified="2021-04-07" version="1">MTPPIRAVIADDQMMVRQGFTVLLNAEPDIEVVGQAVNGLDAVAQAAELAPDVVLMDIRMPELGGIEATRRITACEGSTVKVLVLTTFDLDEYVYEALRAGASGFLLKDASAEELAHAVRVVAAGDALLSPNITKRLITEFSRTAGAPRAPLKERIGDLTERETEVLSLVAAGLSNAEIAGQLILAEQTVKTHMGRILVKLGVRDRTQAAVFAYESGLVRPGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCX0</accession>
    <name>A0A7K2ZCX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_12950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000602">
        <property type="protein sequence ID" value="MYW30169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="25"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="432" mass="43722" checksum="6468F355DA062A65" modified="2021-04-07" version="1">MVRSVNARAARTAAATGTSRLLTRPMLLLLMASVGGMGGFYLLLSVLPLHAATAGGGGVGAGLTTGAMMLATVLAEPAVPWSLARFGHRAVVGAGLLLLGLPSAVLCLWSSFPLTLGVCLARGVGLGIVVVAGTALAAELAPPGRRSESLGLYGVSLGVPSVLGLPAGVWLSDRLGFEPVFLLTAALTLLALPAVAGLPARRATRGEPLSGDPDGRKGDPGGRNGELGGRSEDPGARDGTPGGPLGAAVNRSLVRPTLILGAATFASGVLVTFLPLALLGGPSHLAVVALLVQASVAPLARWGAGWWGDRHGSSSLLLPAVFAVALGTAGLVRLESPVMVIVSMVLFGAGFGAVQNLTLATMFERVPRSGFGRVSVVWNLAFDAGMGLGAVGFGLLIDRTGYPWGFAVTAVLLLAVLVPAWHDRRYVQAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD88</accession>
    <name>A0A7K2ZD88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4244 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000651">
        <property type="protein sequence ID" value="MYW30304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="53" mass="5394" checksum="0978ABBE4809784E" modified="2021-04-07" version="1">MGGSSDRGMTTSEYAVGTIAACAFAAVLYKVVNSGPVMSAMQSMIEGALDAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZE77</accession>
    <name>A0A7K2ZE77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GT040_15545</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="WWKE01000727">
        <property type="protein sequence ID" value="MYW30654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018514188.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000727.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="268"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MYW30654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="423" mass="44581" checksum="6DA2938627D9366A" modified="2021-04-07" version="1">MGLVVQKYGGSSVADAEGIKRVAKRVVDAKRNGNQVVVVVSAMGDTTDELIDLAEQVSPIPAGREFDMLLTAGERISMALLAMAIKNLGHEAQSFTGSQAGVITDSVHNKARIIDVTPGRIRTSIDEGNIAIVAGFQGVSQEGKNITTLGRGGSDTTAVALAAALDAEVCEIYTDVDGVFTADPRVVKKAKKIDWISFEDMLELAASGSKVLLHRCVEYARRYNIPIHVRSSFSGLRGTWVSNEPQGDQKVEHAIISGVAHDVSEAKVTVVGVPDKPGEAAAIFRAIANAEVNIDMVVQNVSAASTGLTDISFTLPKAEGRKAIDALERAKGSIGFESLRYDDQIAKISLVGAGMKTNPGVTAGFFEALSDAGVNIELISTSEIRISVVTRADDVNEAVRAVHTAFGLDSDSDEAVVYGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEC9</accession>
    <name>A0A7K2ZEC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000736">
        <property type="protein sequence ID" value="MYW30711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="211" mass="22640" checksum="0EFB07F8C58DBB37" modified="2021-04-07" version="1">MVIPVLTPDQLDAQASQLHDTQAWQSIVSGWELTAPEPGPPPAPAPAPAPGRQPSDWRSLLSVPVDRLIDDALRTLPAAPPPERPLPGRLGAVLPDRVHAWRRVGQGDLRPSVHLGYARQILAEWGWQNTPYRLRNARGARCVCGALLTAHRLGYGSPTTVNRAGAWLITELRSQGWPGLIGPWNRAPGRTAADALALIDAAARRAAAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEQ3</accession>
    <name>A0A7K2ZEQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multicopper oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_16135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000758">
        <property type="protein sequence ID" value="MYW30765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13896">
        <property type="entry name" value="CuRO_3_CopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034279">
        <property type="entry name" value="CuRO_3_CopA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029626257" evidence="4">
        <location>
            <begin position="26"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="78"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="269"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="412"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="527" mass="55601" checksum="5FC825E5746AA8EC" modified="2021-04-07" version="1">MPMYQPTRRAVLGAALAVAGTGVLAACSDGGGHGGAHAPGGARDSGTYVSPGGKEVAAAEEARGSGPVREVSLTATRTRLDLGGSTTVASWAYGDRLPGREVRMTAGETLDLTLANHLPQPTSMHWHGLALRNDMDGVPGLTQRAIAPGSDFRYRFAVPHPGTYWFHPHSGVQQDRGLYAPLIVEDPKEPLAYDKEWVVVLDDWVDGVDGSTPDAVLKELSGGMGGGMDHGAHTMSGAAASEAEDPDGGSPSRMMMGARSELLGGDAGDVAYPYYLVNGRVADDPEVFRARAGDRIRLRIINAGGDTAFRVALGGHRLTVTHTDGFPVRHTEGDALLLGMGERYDVLVTAGDGAFPLVALAEGKDAAALAVLRTGSGAAPGASVRPKELDGKLVQAGRLVPDPSVALAERAPDRTIRMRLTGGMADYDWAFDGQPYDAKQRRPVEAGERVRVVFDNGTAMWHPLHLHGHTFALGGNAAGARKDTAIVLPHRSLTVEFDADNPGLWMVHCHNVYHAEAGMMTVLGYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFE4</accession>
    <name>A0A7K2ZFE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1214 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000834">
        <property type="protein sequence ID" value="MYW31073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1214" evidence="1">
        <location>
            <begin position="71"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="197" mass="21558" checksum="0E8CB193A1A5C75E" modified="2021-04-07" version="1">RVEGVSRAGTGGGGGRPGSWNLDPHVFDYNLDHFGVGTIDSPQWRFADREVSYLARAVAARIGLWGNHGYEAVYAQTFQDSEGRQLNGAHSYVLRFPEPPPVESFWSVTMYSTPDYYLVDNPAGRYSIGDRTPGLVHADDGSLTLHLSHDRPDDPARAANWLPAPAGDFRPMLRLYTPGAAVLDGGYEIPAVERVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFH5</accession>
    <name>A0A7K2ZFH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000835">
        <property type="protein sequence ID" value="MYW31076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="10131" checksum="6324CD3C5D62635B" modified="2021-04-07" version="1" fragment="single">MSTENELFSAVDALLEQVAQDDLPVPAERKRLREAAGLSQAQIATALDARREAVGNWETGKTEPRPPKRAAYARLLEGLAARFPAPAADAPAAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFS2</accession>
    <name>A0A7K2ZFS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">GT040_18335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000861">
        <property type="protein sequence ID" value="MYW31178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509907.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000861.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW31178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="305" mass="33039" checksum="A341F5EE92F7513B" modified="2021-04-07" version="1">MGAQLRVYKRRIQAVTATKKITKAMEMIAASRIVKAQRKVAASMPYATELTRAVTAVATGSNAKHPLTTEAEAPTRAAVLLVTSDRGLAGGYSSNAIKAAERLRERLAGEGKEVDTYIVGRKGVAYYGFRERKVEEFWTGFTDNPAYSDAKRIAAPLIEAIQKETAEGGVDELHIVFTEFVSMMTQNAIDDRMLPLSLDEVAQESTRKGEILPLFEFEPSAEDVLDALLPRYVESRIYNALLQAAASEHAARRRAMKSATDNAGDLIKSLSRLANAARQAEITQEISEIVGGASALADATAGSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG74</accession>
    <name>A0A7K2ZG74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_19085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000889">
        <property type="protein sequence ID" value="MYW31318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="81" mass="9201" checksum="C5FC20824F588BDC" modified="2021-04-07" version="1" fragment="single">MAQSLADLTSAGVQRILRFFPESSQAEREELRATARRLLDTHGEKVLTPLRPVERVLWYLASEGRAEDLVEVVRGQRRDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG85</accession>
    <name>A0A7K2ZG85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_19040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000885">
        <property type="protein sequence ID" value="MYW31309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="81"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="23990" checksum="6814CB545C9BC9E6" modified="2021-04-07" version="1" fragment="single">MSWLRALKETARSGLEIERQRLEPLIAFRGAAGLALVVGTSLVLFGPEIAASSAFGAFQAAIATFQRSWRPRPVLALVSGASLAVSTFVGYVSASQPVLFLCLLGAWTFLAGLAWAAGPTGGIIASSNVAIMLVTITLPTSVVDAAAHAGMILVGGVVQAALIVLFPVRRWGAQRDALADALAAEADYARRLRHDPVAPFDPLPLMTARSAAAVTPRQARRRPAELAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGE1</accession>
    <name>A0A7K2ZGE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTTM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_19485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000911">
        <property type="protein sequence ID" value="MYW31396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="6">
        <location>
            <begin position="35"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="30506" checksum="92890C44C1819C61" modified="2021-04-07" version="1" fragment="single">MTTTPPTAPVTGRPAPDRIAAAGTALARAIQRVTASALGPYQSAVIRIGFAATYLFFLVRELPHRHELYGPDSPWHWDLARQLTAGNEAFSVLLWSDSVLWFEVVYALTILSAAGLLLGWRTRTMSVLFMVGVLSVQNRSVFMGDGGDNVIHLMAIYLVFTRCAQVWSLDARRAARDTERGALGLPPRRDVVGPVFWAVLGPVLLGATLMDGLGGTWWLPVLLWILWLSAAAWWAANRFAPGGQPRALLDVLANLAHNATLVVIMVEVCLIYASAGWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGJ3</accession>
    <name>A0A7K2ZGJ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_19880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000926">
        <property type="protein sequence ID" value="MYW31474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030568729.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000926.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="12972" checksum="72F6D02F05C96609" modified="2021-04-07" version="1">MDRGTVGSANRGRLQVEARTEGHSEVVTPVGELDHHTADLLREPLESAVEQGRSRLVVDCSRLDFCDSTGLNVLLGARLKAEAVGGGVHLAGMQPVVARVFEITGAEAVFTVHATLEDALRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGM5</accession>
    <name>A0A7K2ZGM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000935">
        <property type="protein sequence ID" value="MYW31511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="276" mass="30266" checksum="96909AA2A7E37EDB" modified="2021-04-07" version="1">MTDPVDQTPGSGHPTDETSGTGLVGGGTTVVVRIGDTVRRPVRSWSGRVHILLDRLRAAGFTGAPRFLGFDRRGRETLDHLDGHVGNYPLSDEVRSERALSSAGRLLRAYHDATTELAAEDLPGWQFAALDPVEVICHGDFAPYNCVFTGETATGIIDFDGARPGPRAWDLAYALYRFAPLTHPANTDGFGRAEEQARRARLFLDAYGCTRNQRIAAMDTVAVRLRSLVAFMRRSAADGDENFARHIADGHAGLYLRDIDHIKAHAATWQKYIADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGV3</accession>
    <name>A0A7K2ZGV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoI</name>
        <name evidence="8" type="ORF">GT040_20400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01000966">
        <property type="protein sequence ID" value="MYW31572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW31572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="194" mass="21580" checksum="CDC4260E60870503" modified="2021-04-07" version="1">MPPIPGSGLAKGLAVTLRTMTKKTVTAQYPDTQPELPPRSRGVIGLFEENCTVCMLCARECPDWCIYIDSHKETVPPAAPGGRERSRNVLDRFAIDFSLCMYCGICIEVCPFDALFWSPEFEYAETDIHELTHERDKLREWMWTVPEPPALDPGAEEPKEIAAARKTADKLATQEAQQAQQAEQAPQSEEGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGZ3</accession>
    <name>A0A7K2ZGZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">lysA</name>
        <name evidence="7" type="ORF">GT040_20595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="WWKE01000971">
        <property type="protein sequence ID" value="MYW31610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="73"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="333"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW31610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="463" mass="49881" checksum="A59A801C72F5CA77" modified="2021-04-07" version="1">MSRSAHPAGPRHADVLTEGHYSAPAADLNVLDEKVWSRTVTRDADGALTVGGIGVARLAEEFGTPAYFLDESDFRARCRAWSDAFGPDADVFYAGKAFLSRAVVRWLQEEGLHLDVCSGGELTTALDAGMPAERIAFHGNNKTVAEIERAVEAGVGRIVLDSFQEIVRVAHIARSHGVRQRVQIRVTVGVEAHTHEFIATAHEDQKFGIALADGQAAEAVRRALGLDSLELIGIHSHIGSQIFDMAGFEVSARRVVQLLAEVRDEHGVELPEIDLGGGLGIAYTSDDDPREPHEIAKALSDIVTRECESAGLRTPRISVEPGRAIVGPTAFTLYEVGTIKPLEGLRTYVSVDGGMSDNIRTALYDAEYSVALVSRTSDAEPMLVRVVGKHCESGDIVVKDAFLPADLAPGDLLAVPATGAYCRSMASNYNHALRPPVVAVRDGEARVIVRRETEEDLLRLDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHJ6</accession>
    <name>A0A7K2ZHJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001022">
        <property type="protein sequence ID" value="MYW31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="223"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="325" mass="35307" checksum="2A703A721F12F920" modified="2021-04-07" version="1">MVVTEEMHVPSWDLYELSIPCTVFGKPQPDLAEPWYDLRLCGTGEPGQDPGTPANGTTGLSLHTRYGLADLAGADTVIVPSVPDACVDEGRPLPPDLITALRHAYDSGARMVSLCTGAFALAEAGILDGRRATAHWLHTAQLAARYPKVKVDDSVLYVDDGDVLTSAGLTAGLDLCLHLVRRDLGAHVANQLARRMVVPAHRPGGQAQFIDQPMPATDDRGLAPVLDWARERLDEPLTVEDLARQAAMSPRTLYRRLQAATGVTPLQWLLNQRIRRAQSLLESTDLPVSRIGELSGLGTANNLRHHFLKQIGVSPSDYRRAFPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHK9</accession>
    <name>A0A7K2ZHK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001019">
        <property type="protein sequence ID" value="MYW31805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="158"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="306" mass="33128" checksum="5E00E8D88A23891E" modified="2021-04-07" version="1">MTVIVRDFRPSDAEAWTRVRRMSVPYLVSTPEQVTHDLAHAHPDRHYRLLVAERDGQIIGTAQAGIAHEGTEPGQGFCTPHVLPGHTGHGAGSLLLSTAEEHLAQAGATVVHAWVLDRPESLEFARGRGYRPGRSAHFQHLDLAGGALPPLQEVPAGVELRPGSDFADDPRPLFDADAQVTLDEPTDIPTELDDYEDWLTNVWRHPPFDAALTTVALVDGRVAAFSAAGTDGSRTYSSNMTGTLRAFRGRGLAKLAKNDSLHRARAAGYTDAYTANDTGNGPMLAINKWFGYTVCATEVRHARTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHL6</accession>
    <name>A0A7K2ZHL6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">carA</name>
        <name evidence="4" type="ORF">GT040_21845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001025">
        <property type="protein sequence ID" value="MYW31846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="364" mass="39265" checksum="CF74112E680BF0C9" modified="2021-04-07" version="1">LEDGRAFHGRAYGAVGETFGEAVFSTGMTGYQETLTDPSYHRQVVVMTAPHVGNTGVNDEDPESGRIWVSGYVVRDPARKPSNWRSRRSLDEELVAQGVVGISGVDTRALTRHLRERGAMRVGIFSGNAIADEGTLLAKVRQAPEMTGADLSAEVATKEAYVVPAVGTKRFTVAAIDLGIKGMTPYRMAERGIEVHVLPATATLEEVYAVSPDGVFFSNGPGDPSTADHPVALMRGVLERSTPLFGICFGNQILGRALGFGTYKLKYGHRGINQPVQDRTTGKVEVTAHNHGFAVDAPLDQVSDTKFGRAEVSHVCLNDQVVEGLQLLDRPAFSVQYHPEAAAGPHDAAYLFDRFVSLMEGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHW5</accession>
    <name>A0A7K2ZHW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_22365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001061">
        <property type="protein sequence ID" value="MYW31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="290" mass="32510" checksum="38D7032A999F6F29" modified="2021-04-07" version="1">MPPVKPSTVLGRQLGDELRRFREAAGFSTADAAEVLDCTKGKISRIENGHVPVRSPDLAALIHAYGVTDPEARDRLASLARSANRRRREGWWHQFGDVLGDTYRDHIEMEAICDSIKTFQVQLVPGLLQTPAYGRAVTVASRAWQTAEEVDQFVQVRMARQERLTGDNPLEFWAVLMEGVLRQQVGGPALMHDQLQHLADLAERPNITVQVLPFSRGAHPGMFGPYLMLSFPRVSALDLVLTETPTGNIWIERESDVARYRGLFDDARTSALPPTESLSMIRRIAKEYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI14</accession>
    <name>A0A7K2ZI14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(2,3-dihydroxybenzoyl)adenylate synthase</fullName>
            <ecNumber evidence="5">2.7.7.58</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_22635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.58" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001064">
        <property type="protein sequence ID" value="MYW31993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008668">
        <property type="term" value="F:(2,3-dihydroxybenzoyl)adenylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011963">
        <property type="entry name" value="DHB_AMP_lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02275">
        <property type="entry name" value="DHB_AMP_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="33"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="4">
        <location>
            <begin position="448"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="549" mass="59353" checksum="937F925C1421DA45" modified="2021-04-07" version="1">MSTRAAPTWPAEFAERYRAAGWWRGETFGEMLRQRAEEHPDRVAIVDPVAGSRWTYADLDRRADRLAAGFLARGIAKGDTVVVQLPNIAEFFEVIFALFRIGALPVFALPAHRESEIAYFCEFTEAVAYVIAAESGGYDYRELAAKTRAQVPTLRHVFVAQGDPGDFEALAEVAEEPVGYGGPRPDDLAFLQLSGGSTGVPKLIPRTHDDYIYSLWGSNEICGVDENSVYLVALPAAHNFPLSSPGSLGVLYAGGRVVLCPQPSPEVAFPLIEREGVTITGLVPPLALLWTEAAPGSAHDLSSLDVLLVGGAKFSEEAARRVRPALGCTLQQVFGMAEGLVNYTRLDDPVETIVTTQGRPISPDDEILVVDDEDREVAPGGTGHLLTRGPYTIRGYWNAPEHNARSFTEDGFYRTGDVVRVTESGHIVVEGRAKDQINRGGEKVAAEEVENHILGHPAVHDANVVAEPDPYLGERVCAYVILRSGAGPLKAVAIKRFVRERGLAAYKVPDRVEFVDAFPQTGVGKVSKKDLRNAAARTADPAPAPAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZI78</accession>
    <name>A0A7K2ZI78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001076">
        <property type="protein sequence ID" value="MYW32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="13586" checksum="A1DA104EBEC5BC23" modified="2021-04-07" version="1">MNSTPERSGDDSTAGQEVLVSLSRCDLADARSVFGVLGSAFDSDRDAGDEPEATSGPRPTVWVTTVDVSEPKAAAGPVTLTAPVTVDAQGGYWAVDRLREHLTGAFAVRVVGTAAGDQEQEVRLRLENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIS0</accession>
    <name>A0A7K2ZIS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_23920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001115">
        <property type="protein sequence ID" value="MYW32234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1286"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2339"/>
            <end position="2413"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1321"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="2504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW32234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="2504" mass="269086" checksum="28987F8911DECCCB" modified="2021-04-07" version="1" fragment="single">MVSPPRWKTVFGALEEAAAQAPGTKIHLYDANGSYDVTTYGTLHEDALRLSGWLTGHAGMRAGENLILQLNNAHEYLRVFWAAVHAGIVVVPLSVPNIVDRNNLESVSRVLATLGSGRVIVGPGLAEVYLPAVADAGVERDAVMVLPQHAELPSAGGASGVQAAEPDGAAVIFFTSGSTGAPKGAVQTHGAILAREAGVMQSDGGGRDVQLNWMPLEHAAGILMSHLRGVCRLSEQVQVAPGHILADPLVWLDLIDKYRVNYTWAPQFAYSLLGNLVPGREHASWDLSCLRESINAGEMLNARAIAQLTTQLSGFGLRPDVFVPVWGMAETCSGVFYNREFVPATGESATPEDGEGAGRVPKFVALGRPIPGLEVLVADDDGAAVPQGQVGHLLVRGECVTRGYLHHPTANEESFTPDGWFRTGDLAHVRDGVVTMTGRAKQILIVNGLNFDLSEVEAAIEELPAVETSFTAAWAHTDPATGEEQAVVFFVPRAGRTAEPVTHEPATDEPVTDAIRAHVLRRIGIRLHAVIPVRREDIPKTNLGKIQRAKLGAAYRDGLFADRTAGQDGDERRRALLADALRPLIGPGRYLTASANELGRTRSAPGAGTTGGIALGGLGSGWARSTGIETAVNALPGVAGSRVWTADVLLPGMPGAVVAIEPRSGHADYRAAVHERAVRAVKANGIVHHEVAFVEGIAARPDAELLEALLGGAAAGSVDLAPARPVGVYADTLVGADAEALPARQRPAPALAVFADDEGTLAGFLGSEGRRVVWVRPAEGGGEVRLESGGLPGVLTAEVDPHSSEAYAQLGAALRGAGIESLEIAHLWALRPPAEAAGSGGILGAQARGVFSVQNLLRELPAAGVAISYGAVFTRDALGVLPANPGYGSAPIAGFVRSAVAEGHALTHIDLSGANDGPGEGLATLFEREASQPHDGLSVAYVDGRRRKQAVEPLTLPATGPSLDGQNGFLVVTGGLGGIGRILVALLLRRFRRNVLVLGRREEAAVQDQVSAFEAIADEHGGTLTYARSDLQDPAQLRETIRHHAASSGLALHGVFHLAGMVHEALVGDQSTEELTEVFKPKVAGLHHLGGLLAQEHRDAFLVTFASARSLAPGATVSAYVAASDFAGHYSAHLRSQGVRATSVAWGVWDETGMSRDLKVNRSLHRRGIETIEPLQGLGALLDALRTDRPAVYIGVDGSRLPHGLTAGSDDPSPEPACVVTDFGDFERLFAPRAEAVEDTVHDHLGGVRLRYEILDELPVDRNGLVDRDMVLDRLDVLRGAVTVEPPRDATEERIRDICRAVFRVGTIGVTENLFDLGADSIATIQLLAKLRDDGVAVISHEEFYREPTIRHLAGQAAGSTTPAAPALPSQTVDATAEVPLTPQQRRLWFLFQADPASPYYNNTVSIEVSGGVVRPLLKTALMTLVDRHEGLRVRFREDASGTFWQRPVPIEEVDLAFDEHDLRDLPESDRARRLDGIIAASAATPFDLLSQLPLRAAIVTSADDRVTLVLTIHHIVSDGWSMGVILSDLASIHDDLLEHGASKLAPVRGLYGRYVADVTAYENSAGYQEQLAYWTDELGQVTVPVELPARANSTEAPTSDGEHHESTVGPEVLRGLRKLARDHDVSLYVLLLAAYAVLHQRLTLSHHVRLGTLIANRGRGNTSDMVGFLANTLPLDIRIDDAEPFSALVQQVKRKVIGLHDHQDVQFDSLVQALQPERAHNKNPLFQVLFVLQNAQIERLSTPRADWRLKIWESDTAKFDLSIQAFERDGDLDLVFEYRRDLFPRRDVERWVEAYHTVLRDLPGLPDPEVGHIDVVPEAERERILSVNGPLDAPLPSSIPAVLSAVARERADRPALVMGAESYTFAELWDRSAAYAAYLRAEGVVPGSRVGITARRSPHVVIAMIAVARLGAAYVPVRPSDPEERRKLVLSDSEALVLLDDAAAEPLGDVLQLPLAVYDAAVPEPGPAWHETDDASTPAYIMYTSGSTGRPKGVAVSVENVLRLAHQPDFVELGPGDVVLQTGSLTFDASTLEVWGSLLNGAALHLVDEHVLLDITALREAIDGSGATVMWMSAPLFSQIVDFDPGVFGPLRQLLVGGDVLPPRQIRAVVEACPGIRIINGYGPTENTTFSTTYRIPDDVPADRAIPIGRPIGHSSAYVLGGAGRLQPIGVPGELHVGGRGVALGYVNRDDLTAASFLDDPFAEGGRMYRTGDLVRLNDELDLEFIGRVDHQVKVRGYRVELSEIELAVRSLEYVRDVAIEARTPEGGTLRLVAFYTADGDADIRADLERLLPDYMVPAVFVRLDRLPLDRNGKVDRRQLSDIEITVGGTSGDDTADEGLSPQANELRRIWADLLGFDTFGADDNFFSLGGDSIQVIQMTNRLRGSGYQVSAKEVFENQSIRRLAALMVPSAPHAPADPSVNTVERAGTAELAPVQAWFFETLGGDDWLDHWNLPLVLDLDEDYPLPRISQALRAVQEQHPALRARFWREGATWHYQEGLPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIY2</accession>
    <name>A0A7K2ZIY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan bridge formation glycyltransferase FemA/FemB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_24315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001138">
        <property type="protein sequence ID" value="MYW32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="157" mass="17025" checksum="E251647BAB486CD4" modified="2021-04-07" version="1" fragment="single">MSALLVPSSSSPAHPRRNGDGDRNRDIVLGPITAQTYRAFLASPHGEALGAGFLQCPSWADVKEGWRAQLLGWGPDPEAGELAGVALVLLRQFPGTRKYFAYLPEGPVADWSDPDLDAWLTPLLEHLRRTGAFAVRIGPSPAHRRWSAARLKPLTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ57</accession>
    <name>A0A7K2ZJ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001155">
        <property type="protein sequence ID" value="MYW32383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="144"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="370" mass="39711" checksum="68872F4C1044B342" modified="2021-04-07" version="1">MKLPGQDAMARRADEHVVPTRVMLPRRVTHGPARQVGKRLLMALLVLAATVLIVWLDRAGYNDNADGKVDLLDAVYYATVTLSTTGYGDITPYSAGARLINVVLVTPLRVMFLIILVGTTLEVLTERTREDFRLKRWRANLRDHTVVVGFGTKGRSAIQTLCATGLAKEQIVIVDPASKVIEAANAEGFTGVLGDATRSDVLLRAELQKARQIIIATQRDDTAVLVALTARQLNRGAKIVAAVREEENAPLLRQSGADAVITSASAAGRLLGLSVLSPSAGTVMEDLIQQGSGLDLVERPVIKAEVGKSVRETEDLVVSVLRGHRLLGYDDPAASPLQLTDRVITIVRATPPTGSGPSGPHLPHLPPHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJA8</accession>
    <name>A0A7K2ZJA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="7">2.7.1.49</ecNumber>
            <ecNumber evidence="7">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thiD</name>
        <name evidence="7" type="ORF">GT040_24480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="7"/>
    <dbReference type="EC" id="2.7.4.7" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01001150">
        <property type="protein sequence ID" value="MYW32339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="6">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="269" mass="27402" checksum="DE3620041B8C9597" modified="2021-04-07" version="1">MPIRTAVPPRVLTVAGSDSGGGAGIQADLKTMLALGVHGMSVLTAVTAQNSLGVQGAWELPVDAVRAQYRSVVDDIGVQAVKTGMLASAALVETVAGLLAGTDAPVVVDPVGVSKHGDALLAAEALDSVRTKLLPVATVATPNLDEVAQLTGVQVTDEDGMRRAAEEILAFGPRWALIKGGHLPGDAVDLLTDGSAEHWLRAPRYDNRHTHGTGCTLASAIASGLALGQDVPTAVEGAKAYVTGAIRAGFALGGGIGPVDHGWRTRQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJR0</accession>
    <name>A0A7K2ZJR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_25710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001199">
        <property type="protein sequence ID" value="MYW32574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW32574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="287" mass="31021" checksum="8A83F6BFB2C4F3C5" modified="2021-04-07" version="1">MVAQFITETRSEAEDVPRLAARGVTVGYGGRVVIDDLDVVIPSGVVTTIIGPNGCGKSTLLRTLTRLLKPASGTVVLDGEDIDRLRTRDVAKKLGLLPQAPVAPEGLTVGDLVARGRHPHQSWLRQWSSDDAEVVERALDMTGVADLADRPVDSLSGGQRQRVWISMTLAQGTDLLLLDEPTTYLDLAHAIDVLDLVDDLHESGCTVVMVLHDLNLATRYSDNLIVMRAGSILAQGHPRDVITAELLHEAFGLQAKVIDDPVGDRPLIVPIGRTHVRLEPVSDARVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK19</accession>
    <name>A0A7K2ZK19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lepB</name>
        <name evidence="7" type="ORF">GT040_26350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="WWKE01001228">
        <property type="protein sequence ID" value="MYW32697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW32697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="229" mass="25023" checksum="69218BE878180EA0" modified="2021-04-07" version="1">MVRAGARRAGTRRHRPFWVELPLLVGIALILALLIKTFLVQAFSIPSESMQNTLQKGDRVLVDKLTPWFGSEPERGEVVVFHDPDGWLDDVAVDPPNTVQKVLSFIGVMPSAEEKDLIKRVIGVAGDTVECVGDGPVKVNGKALDEPYVFPGNTPCSNDDKGTFKVTVPPGKLWVMGDHRQASADSRYHSDDRNKGMVPVDEVVGRAVVVAWPAGRWDTLPVPATFSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK49</accession>
    <name>A0A7K2ZK49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_26500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001247">
        <property type="protein sequence ID" value="MYW32724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW32724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="23112" checksum="CE15251C2441BCC2" modified="2021-04-07" version="1">MSVDWSWIADHTDDLTALTLSHLQAALTAVLLGLLVSFPLAVVAHRVRRLRGLLLGLSNVLFTIPSIAVFVLLLPVSGLTRTTTVIGLTIYTLVVLLRNTVEGLDSVPTKTKEAAKAMGTRPLRTLLTVELPLALPVIMAGVRIATVMAISLVSVATYIGDGGLGQLFTDGFQRNFPTPVIVGVVLTLLLALVADALLVTLQYVLTPWTRRQKQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK59</accession>
    <name>A0A7K2ZK59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="10" type="ORF">GT040_26560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="WWKE01001248">
        <property type="protein sequence ID" value="MYW32736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW32736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="219" mass="23773" checksum="2ED745A744ED7942" modified="2021-04-07" version="1">MRIVLVGPPGAGKGTQAAYLAENLSIPHISTGDLFRANMSQGTDLGKQARAYIDAGQLVPDEVTIGMAKDRMGQSDAVNGFLLDGFPRNVGQAEALDVMLKDEGVKLDAVLDLEVPEDEVVKRIAGRRVCRRDSSHVFHLSYSPPKAEGVCDVCGGELYQRHDDSEETVRTRLEVYHTQTEPIIDYYRAQGLVVTISALGEVADVTARAMEALKQSDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKW0</accession>
    <name>A0A7K2ZKW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001301">
        <property type="protein sequence ID" value="MYW32994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="115" mass="12798" checksum="5BD609A6FA9992DC" modified="2021-04-07" version="1">MTVRRVMPLVQSEAMRESREFYGLLGFEEVMNHGWIMTLAPPSSPSAQISIISSDATAPFTPDLSVEVDDVDAAYAVVRASGAEIVHPLQDEEWGVRRFMVRDPNGRVVNVLSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZL79</accession>
    <name>A0A7K2ZL79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA polymerase III subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_28545</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001323">
        <property type="protein sequence ID" value="MYW33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="10">
        <location>
            <begin position="121"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="245" mass="25520" checksum="708FDAD5A156C7A2" modified="2021-04-07" version="1">EAAEFAAAVADVAVAAGRDDTLPALTGIRLGLDAEAGAMTLAATDRYRFAVRTLPWKAADAGGGSADVLVSARRLTEIARSLGRSGLVSVALDAGSAGFEHAGTRTTVRLLDGRLPRHDKLFAMESPAVAVVDRARLVEAVKRVSVVADGDSPVQMAFSAADNSVHLQAGYEDDVASQRLPATLEGAREMTVAFNPGYLADALASFDEPSLRLLMMGAGQRAMVTGEAGSDAHRHLLMSVKPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLB8</accession>
    <name>A0A7K2ZLB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_28625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001329">
        <property type="protein sequence ID" value="MYW33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="192" mass="20020" checksum="05F22D8EFC4A08B2" modified="2021-04-07" version="1">MAPAPSSTTSAITLNINGEKHHLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLLGGRRAVACLTLAVAAEGREVTTIEGVADGDDLHPVQQAFLELDGYQCGYCTPGQICSAIAVIEEHAAGWPSAATDDVRPEATPPPLTPDEIRERMSGNLCRCGAYVSIVQAVSRGAQAHAQSRTAAAEEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLG9</accession>
    <name>A0A7K2ZLG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1844 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001351">
        <property type="protein sequence ID" value="MYW33195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018515311.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001351.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="121" mass="12676" checksum="C70F3949A02C8A9E" modified="2021-04-07" version="1">MSDATPTSSENPGFDAMARDIAEVPAVEVIVTVAVNLMSAAAVKLGLTEEGEDHKDLDEARKLVHALAGLLDASTTEISTFHASPLRDGLKSLQLAFREASLVPDEPGKGPGEKYTGPVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLK1</accession>
    <name>A0A7K2ZLK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_29265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001357">
        <property type="protein sequence ID" value="MYW33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014488">
        <property type="entry name" value="UCP017371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017371">
        <property type="entry name" value="UCP017371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="147" mass="16051" checksum="FD8D25BB8FC5F206" modified="2021-04-07" version="1">MAQVEATTERIIAADAEAVFDALADYKDVRGKVLTAHFSEYEVREGGDGEGTLVHWKLQATSKRVRDCLLEVTEPTDGQLVEKDRNSSMVTTWTVTPAGEGRSKAVVTTVWDGAGGIGGFFERTFAPKGLGRIYDELLQNLATEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLV0</accession>
    <name>A0A7K2ZLV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_29240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001356">
        <property type="protein sequence ID" value="MYW33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="168" mass="18421" checksum="240E7DBB7557E0BC" modified="2021-04-07" version="1">MALNDTLARVDADLAAGRIPVARQRLRGLVSSYPHEPAPRRRLAEVYRLYGEPAEAGRWMYLEEDRSPEETAAFEERYANAVGLMRAVAWRGTESDAPTPFAAGQLTAVREAASEIVGRPVTWDGLVEVKGNARQISPLTDALTGIGCLLLTVAFLGIWVYGLFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMM4</accession>
    <name>A0A7K2ZMM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_30980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001435">
        <property type="protein sequence ID" value="MYW33570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="81"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="357" mass="38059" checksum="1E568A3910EFC3A0" modified="2021-04-07" version="1">MAGSPHCEPEVEESEPLRSDANIAGPMTDPVPGPRTEPVGDGVSRETPPPMDDTPIGRAAQLAVEALGRAGEGLPRPDRTRVIVVANQKGGVGKTTTTVNLAASLALHGARVLVVDLDPQGNASTALGIDHHSDVPSIYDVLVESRPLSEVVQPVPDVEGLFCAPATIDLAGAEIELVSLVARESRLQRAIQAYEQPLDYILIDCPPSLGLLTVNAMVAGAEVLIPIQCEYYALEGLGQLLRNVDLVRGHLNPDLHVSTILLTMYDGRTRLASQVAEEVRTHFGKEVLRTSIPRSVRISEAPSYGQTVLTYDPGSSGSLSYLEAAREIALRGVGVHYEAQYAHAIQNSQQNVSEGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMN0</accession>
    <name>A0A7K2ZMN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_31165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001436">
        <property type="protein sequence ID" value="MYW33606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW33606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="465" mass="50181" checksum="B6AECED3255BA1B7" modified="2021-04-07" version="1">MTTSPPQVNGHRRRIPVITDWQTLLAAPAEEPVAAPTLEAQPESATPSVDLVAQAEADAIRTKAYADAEEQRARAEAEAEAVRIKAEGEAKAAEIKAAEEARKLKLANDKAQARAIEEQAARNARIAKSNRERAEAERGQKDDERAHREQQQTAAAAEADVAKAATTWRKYAIAFYAVCAVVALPVQIAAFWDRDAPWLVIAPLMLEGAALVVTKGAAAAVAANRPHWHYRTVAWVFAFIAAGINLKHGLDAFDPATAFGTAFASLAGPGVWDLHEHGRIRRRDGVLTRRQRRAAANAAKEAARKQAAEKAEQEAAKTAAEEAAEAAAAVLAETRKARFPKVWDHALGLAADLGETTVTDAIWRRAKRDVEGADPGESADTIRMRNAAEMRVEAARLRKPVSTLSKSKNAQGGAHLPPASTKPRPKPIPPRRKRGDSTPFHPAAKRLAADTARRSVTTRISTEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMR9</accession>
    <name>A0A7K2ZMR9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsmG</name>
        <name evidence="3" type="ORF">GT040_30975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001435">
        <property type="protein sequence ID" value="MYW33569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513875.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001435.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="238" mass="25481" checksum="D4C8F3C2C41509A6" modified="2021-04-07" version="1">MTDAAELPQAPEEAQAVFGELFPEAVRYAELLADAGVKRGLIGPREVPRLWERHLLNCAVLSEVVPEGVTVCDVGSGAGLPGIPLALVRPDLKITLLEPLLRRTNFLQEVVELLGLDHVTVVRGRAEEVLGTLQPVHVVTARAVAPLDRLAGWGVPLLRPYGEMLALKGDTAEEEINGARAALSKLGVLETEVLQVGEGVVDPLSTVVRVVVGESPGGVRFAAKRAKAARVGRTRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMX9</accession>
    <name>A0A7K2ZMX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2252 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_31545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001442">
        <property type="protein sequence ID" value="MYW33680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="441" mass="48302" checksum="5608B6CE51B6A071" modified="2021-04-07" version="1">MSETQTGAAQRGEQILAVFDTAFGELLAADPAAFRVKFRKMAGSAFAFYRGTACMFYTDLEREQRGGPYLDERTGRVWIHGDLHAENFGTYMDANGRLVFNVNDFDEAYVGPFTWDLKRFAASVALIGYAKALSDEQITDLVRVFAAAYRERIHALATGAKNDEVPPFTLDTAQGPLLDALRAARSLTRFSLLDSMTVIRDFERRFADGGGAIDLDAATRYKVLAAFDGYLETLPESSLTRPDSYRVKDVVGRRGIGIGSAGLPSYNILLEGNSDALENDVVIYLKQAQTPAVSRHITDAAVRDYFQHEGHRTVISQRALQAHADPWLGWTELDGAGQLVAEVSPYAVDLDWSEIDEVDEIAAVVADLGRATATMHAAADDESGHSLVPFSTERAIDAAISADEEGFGELLVDFAHSYGARARADHQIFVDLFRNGRIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMZ6</accession>
    <name>A0A7K2ZMZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001448">
        <property type="protein sequence ID" value="MYW33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="165" mass="17877" checksum="653D9BF6CD610A83" modified="2021-04-07" version="1">MTTTDPHYARYIAGLPKVLAGAACLFRDAEGRVLLVEPNYRQGWALPGGTVESETGEGPRQGARRETVEEIGLDIAPGRLLAVDWVRGADRPPIVAYLYDGGVLTPEQLAAIRLQEEELLSWKLVTRDDLPVHLLGRLEGRVRAALDVLESGAGTVELEDGKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN13</accession>
    <name>A0A7K2ZN13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_31885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001451">
        <property type="protein sequence ID" value="MYW33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018511190.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001451.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="73"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="252" mass="26790" checksum="C61E23046194D527" modified="2021-04-07" version="1">MALKPEPTAPFHSVQYALRVLESVSQHGDGVTDAQISRETGLPPGHLASLLLTLRREGYVEQVSDGAYVIGASLLLLGSGAARRQALEGRLQQALDQLRDSVGAAVYLSRYVDGEISVTQVADGPLTPAVNEWVDFRSSAHASAVGKCLLGQLDHEARRDHLSRHKIARLTSRTITSEKVLLSKLDAQPATVPVLDLQEYAVGTVCAAVPLTAGATAGCLALSLPIEDAHRLREAADTLNRRAAPVLLSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNN0</accession>
    <name>A0A7K2ZNN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Urea ABC transporter ATP-binding protein UrtD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">urtD</name>
        <name evidence="6" type="ORF">GT040_33030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001504">
        <property type="protein sequence ID" value="MYW33966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017781">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03411">
        <property type="entry name" value="urea_trans_UrtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW33966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="265" mass="28073" checksum="E535F098988A9351" modified="2021-04-07" version="1">MSGEGLTVRDLRVTFDGGVTAVDGVDLDIGPGDLRFLIGPNGAGKTTLVDAVTGLVRASGSVRFGGEEIIGEPVHRIARRGIGRTFQTATVFEQLTVEQNLDIAAGAGRSALTLLRRRRNVPGSVGKALEITGLTALRHRPAGVLAHGQKQSLEIGMLLVQDVRLLLLDEPVAGMSHDEREAAGALLQRVSEDRTVVVIEHDMDFMRSFARSVSVLHAGKVLSEGTVAQVQADAKVQEVYLGRASEPEPPAAVTAPTPAPVREEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNN8</accession>
    <name>A0A7K2ZNN8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_32685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="WWKE01001493">
        <property type="protein sequence ID" value="MYW33898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW33898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="23293" checksum="71F21FF072278924" modified="2021-04-07" version="1">MTKGSDRTPLTRDFFDRSVLDVAPDLLGRTLVRHSDEGTIEVRLTEVEAYAGEADPGSHAFRGRTARNSVMFGPPGHTYVYFTYGMWHCLNLVCGPEGHASGVLLRAGEIDVGAGLARVRRVSARNDKELAKGPARLATALDIDRTLNGSDLFADLTPALSVLHGTPPPRDQVRSGPRTGVGGDGAHQPWRFWIESDPTVSPYRAHAPRSRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP57</accession>
    <name>A0A7K2ZP57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001546">
        <property type="protein sequence ID" value="MYW34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018509849.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001546.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="136" mass="14959" checksum="E418EB6F50F62F6A" modified="2021-04-07" version="1">MRIGELAERAGTTTRTLRYYESRGLLPARRAENGYRSYDEGDLRLLQQIRTLQDFGFDLEETRPFVDCLRAGHPAGDSCPASLAVYRRKLDELDALIGQLRSVRAEVGVQLARAELEASAGLPGGPAPRCELGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP93</accession>
    <name>A0A7K2ZP93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_34040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001551">
        <property type="protein sequence ID" value="MYW34163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076965721.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001551.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="323" mass="33916" checksum="D5CC1D110A80B11C" modified="2021-04-07" version="1">MFAAERRQLILEMVRANGAVSLRELARVVQTSEVTVRRDVRALEAEGLLDRRHGGAVLPGGFTRESGFPQKSHLSTAEKTAIADLAASLVGEGEAIVVGAGTTTQELARRLARVPGLTVVTNSLLVAQALAHANRVEVVMTGGTLRGSNYALVGSGAEQSLQGLRVSRAFLSGSGLTAERGLSTSNMLSASVDRALVQAAAEVVVLADHTKLGADTMFQTVPTELITRLVTDEPPLHDERAAAELQALADQGVEVTVAGPDAETGEAPPGDRRPRRDMPLPGQRRTTTGRAGGLGPQLRSASSLSDQASSSGERARVADLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPI6</accession>
    <name>A0A7K2ZPI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001587">
        <property type="protein sequence ID" value="MYW34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="286" mass="31352" checksum="A38F529034ECCA7A" modified="2021-04-07" version="1">MPHARSAPAPLPADAQNLRIELLRSTAEADPRIEGVLLYGSWTLGEADAHSDLDACLYVREEDVDAFDGREFVERLAPLKLAYTNMYGILAVVFDDLMRGEFHVEPTGAGIAEITTWRGQVHIPRPETAVLLDRTGRLTAAARELATFRPPDPATTAQQLTDELANWTLMLAHIQTRGETARAHNLLHAVIAPHQLKLCRLLRGSTTHWLTPSRALETDLPVADIERYATTTGPLTPDALRTAAATSWRWSRELAAEAADRWDTLLPLGLHKEIAEALSPGGGPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPW2</accession>
    <name>A0A7K2ZPW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001620">
        <property type="protein sequence ID" value="MYW34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="94" mass="9853" checksum="B3C38FCDA289D468" modified="2021-04-07" version="1" fragment="single">ATRAGTPATLSALLAHRADTDPARTALICGPRTLTFGEWFERAEALAAGLRSRGLEPGARVVLRYGSGDWAAYAVAFCGVLRAGLVAVPLSDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPY0</accession>
    <name>A0A7K2ZPY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001612">
        <property type="protein sequence ID" value="MYW34400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="171" mass="18915" checksum="4026A53F9D0D3401" modified="2021-04-07" version="1" fragment="single">MKASRHPYLDHATPLAFAHRGGAADGVENTAAAFRRAATAGYRYFETDVHTTADGRLVAFHDPTLDRVTDATGRISALPWSEVRRARVGGTEPLPLFEELLEEFPEARWNVDVKAEPALEPLLELIRRTDAWDRVCVGSFSEARVARAHRLAGPRLATSYGVRGVLGLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPY4</accession>
    <name>A0A7K2ZPY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001622">
        <property type="protein sequence ID" value="MYW34426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="17208" checksum="F46F8796A5AC4625" modified="2021-04-07" version="1">MTFFLGLGIAGIVLLALSLIFGGVLEGMLDGVLDGLFDGLLSLPVIAGFISMLGFGGAIVLGTTGAGPLVATVAGVAAGLVAGWLTWKFSKALMREQTSSTPRGGDLVGTSGMVVTAIPADGYGEVMLRLAGQPVKYAAKCPTPIVRGTEIWVEAELSTTSVAVRPVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQ31</accession>
    <name>A0A7K2ZQ31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_35715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001627">
        <property type="protein sequence ID" value="MYW34481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="263" mass="27523" checksum="EEB2208394365A13" modified="2021-04-07" version="1">MSTPAPATPEGTTPEPGTQPATPTAPPAAPTPPEPAAPTTPTEPVSEPKPSEPKAKAPKFEGDFDPVRAMKAIENLRTEVDEQKQKRAEDKQRAADEQTAFMKKVAAAFGLETDEAKPPTPEELAKQLDEARGETKESRAQARQTQVELAVYKTAGKHGGDPDALLDSRSFANAIAKLDPADTGFDEAVGKAVKAAVDSNKKLAAKAPEPKEPEPTPAGGAPMDGAGGSKKQLGEADRRRMTPEQIAKAVEEGRFAAYLGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQB8</accession>
    <name>A0A7K2ZQB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid hydroxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_36180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001641">
        <property type="protein sequence ID" value="MYW34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="107"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="282" mass="30873" checksum="86B0EB25FC1CC8BF" modified="2021-04-07" version="1">MLRATAYPFLLLAVVLVGASALVLRWDPAIVSPLFLVGTLTYLAVLEQLIPYDRTWHPGKEEWRWYGIYFLLTMAGSGLAQLLVTAAVGWISADERGHHLWAEIPGALLAGSLVSYLVHRLGHTSALLWRLHGVHHVPQKVNVANNGVNHVLDIVLAQSLVQLTLAMAGFSRSAVLVTGLFVVAQGYFVHANIDVRIGRFNHLLASPEQHRLHHSTDLSEAGHYGSDLSCWDHLFGSFTWRPGREPAAVGLHDPASFPGTGEILAGFLHPWRRRPGPAPGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZQV1</accession>
    <name>A0A7K2ZQV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsR</name>
        <name evidence="6" type="ORF">GT040_37095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001683">
        <property type="protein sequence ID" value="MYW34746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="80" mass="9084" checksum="9C782B20E7184D20" modified="2021-04-07" version="1">MARKQDPRQPLKTRPNPLDAAGITYIDYKDTDLLRKFISDRGKIRSRRVSRVSAQQQRQLAAAIKNAREMALLPYSGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR00</accession>
    <name>A0A7K2ZR00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2344 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001688">
        <property type="protein sequence ID" value="MYW34782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="259" mass="27762" checksum="B6C8E8B5CDC6DAC4" modified="2021-04-07" version="1">MQRIRLRYTKRGRLRFTSHRDFQRAFERALRRSEVPMAYSAGFTPHPKVSYANAAPTGTGSEAEFLEIALTEARDPDLLRELLDSSLPDGLDITDAVEARTSGLAERLTASVWEMRLDGVDPDEARRAVDAFNAAESVEVQRKAKNGIRTFDARAAVADLQALDPPADRPGDKPCAILRLVVRHVTPAVRPDDVLSGLRAVADLAPPVPAAVTRLAQGLFDEESGTVTDPLAPDREAAPTAHPAVAAAVATAPEGAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR78</accession>
    <name>A0A7K2ZR78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_37355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001689">
        <property type="protein sequence ID" value="MYW34798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="30"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW34798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="496" mass="50246" checksum="D975A46CAA826E02" modified="2021-04-07" version="1">MTFMSDVTAPAPTRTSRTSRSRIPTGAWAVVLAACTGQFLVVLDVSVVNVALPSMRADLGLSHSALQWVVNAYSIAFAGFMLLGGRAADIYGRKRMFLVGLGVFTAASLAGGLAQEGWQLLAARGAQGLGAAVLAPATLTILTAAVPEGPARTKAIATWMAVGAGGGAAGGLIGGVLTDALSWRWVLLINVPVGALVLVAAALWITEGRAGDRRRIDLLGAVLVTAGLAAVAYGIVQTEAVGWTAAATLVPLLAGVVLLAAFVLVEARTAIPLIPLRVFGVRAVSSANVSMFLMGSATFSMWYFMTVYAQNVLGYSPLQAGLALMPTSAAVIIGSKAAPRIMARTGAKSLAVAGVLITAAGFGWQSTMGVDGSYLTAIMFPGILMMAGAGLASTPLASLATSGAAAGDAGLVSGLVNTSRTMGGALGLAVLSTVAAARTAGSADPAEVTAGYASAFRTACGVLLVGVLVMLAWLPNHRTPRVRQEQAAKVKAQERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZR90</accession>
    <name>A0A7K2ZR90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_37945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001724">
        <property type="protein sequence ID" value="MYW34910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030562428.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001724.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW34910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="199" mass="20929" checksum="4DC6C9709DA79B4D" modified="2021-04-07" version="1">MRVNFTVNGRPQEADDVWEGESLLYVLRERMGLPGSKNACEQGECGSCTVRLDGVPVCSCLVAAGQVEGREVVTVEGLADYAKHREDAHPGGGCASGACGTTLDAAKRWQSKPTDGQAGEAAELSPIQQAFIDAGAVQCGFCTPGLLVAADELLENTPSPSDQDIREALSGNLCRCTGYEKILDAVRLAAARQEEAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRA6</accession>
    <name>A0A7K2ZRA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001697">
        <property type="protein sequence ID" value="MYW34828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="104" mass="11452" checksum="505F01AF90C0F279" modified="2021-04-07" version="1" fragment="single">MPVLVVLPDGQEVTARLWARRETPRGWLYQVGLPAYRNTADGDVQAAEYRVWVRAPDHVRPVDGVSYDAVPTERLPPPSSVREALGPRRPSGWVLQKAGGRGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRM5</accession>
    <name>A0A7K2ZRM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coproporphyrinogen III oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_37835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001722">
        <property type="protein sequence ID" value="MYW34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="35"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="453" mass="50124" checksum="9D8AD332F6A3B2E1" modified="2021-04-07" version="1">MPAVRPYESYVYAYPHKTAYRPLPERPALRELWAAEPKSALSLYLHIPFCEVRCGFCNLFTRIGAPEELTTRYLDALDRQAVAVRDALGDDEPVRFAAAAFGGGTPTFLTPDELERLCDIAEKRMGADLLAVPLSVETSPSTATADRLAVLADRGTTRVSIGVQSFVDAEARAAVRPQRRAEVEAALGRIRDARIPVLNIDLIYGIDGQTERTWLTSLDAALAWRPEELYLYPLYVRPLTGLHRLGAAAADPDAEAVEQAAWDEQRLRLYAVGRDHLLAHGYEQVSMRMFRRADAPRESQDGPEDYACQTDGMIGLGCGARSYTAALHYSFDYAVNMGEIRSIIDGFTATEDFSRAEVGRYVDAAEARRRHLLQSLLQAVGLPLDDYRARFGTDPREDFAAELERFADRGWLDTQAPEGLLRLSPLGLAHSDALGPALFSPGVRAAMAAYERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZRS3</accession>
    <name>A0A7K2ZRS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_38805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001770">
        <property type="protein sequence ID" value="MYW35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="302" mass="31975" checksum="E3F923381B453EA5" modified="2021-04-07" version="1">MSTETKAAAGRDTSRIHNIGYRSYDGRRLGRAYARRSLYSQTLRGSFGLGRSAKSKVLPMLLFGVMTLVAAILVAVSMAAPDATRLVVKYTSYAIYLQAVIGLFIAAQAPQAVSRDLRFKSVPLYFSRPIERADYVLAKLAATASALFILTGAPLLILYVGSLLAKFDFVDQTKWFGQGLVSVALLSVLFAGLGLVMAALTPRRGFGVAAVIAVLTISYGAVSTVQAIAWETGSPGAVEWLGLFSPISLIDGVQTAFLGATSAFPGGEGPGAGTGVIYLFVVLALVAGSYAVLMRRYRRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSN7</accession>
    <name>A0A7K2ZSN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_40215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001835">
        <property type="protein sequence ID" value="MYW35332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW35332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8309" checksum="E6E042267039143B" modified="2021-04-07" version="1" fragment="single">MTTADVDSERPNGRSGHGPADGFEVFRDDWGIPHLKAGGALALARAQGHNAALDRAWQLETERHRVLGTTAAYLGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSP9</accession>
    <name>A0A7K2ZSP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class E sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001834">
        <property type="protein sequence ID" value="MYW35328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="230" mass="25151" checksum="C0A3F5706A9BB489" modified="2021-04-07" version="1">MSARSLRLVVRTFSELCITVGALIVLFVAYVLLWTGVKAADAAEGEIETLHSRWAREPAALSPGPSSSPSPAPYRDGKPFATLHIPRFGAGWEWPVLENTEARTLQKGLGHYSGTARPGETGNFAVAGHRRTYGDPFKDFPRLRPGDAVIVNDGTTWFTYRIAKEPYRTVPTDTAVVDPVPRRSGFEGPGRYLTLTTCEPEWGSSHRLIAWAHLDATLPVNEGKPPDLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZSR3</accession>
    <name>A0A7K2ZSR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001835">
        <property type="protein sequence ID" value="MYW35337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="374" mass="41551" checksum="F384B1540AE125A5" modified="2021-04-07" version="1">MEFGLFVQGYVPAARAKVDPEAEHKALIEETEYVIQADKSGFKYAWASEHHFLEEYSHISANDVYLGYLAHATDRIHLGSGIFNPLAPVNHPVKVAEKVAMLDHLSEGRFEFGTGRGAGSHEILGFMPGITDMNHTKELWEETIAEFPKMWLQDEYVGFQGKHWSLPPRKILPKPYGGAHPAMWYAAGSPSSYAMAGKKGLGVLGFSVQKVSDMEWVVESYKNAVKDAEPVGAFVNDNVMVTSTAICAETHAKAVEIAVGGGLNYLQSLLFRYHDTFPRPEGIPEWPQLLPEYTEEIVELLIAEELMICGDPDEVLKQCRRWDQAGADQLSFGLPIGISPQDTMTTIRLIGEHVIPKIDTDPVHRTSRFRAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZT06</accession>
    <name>A0A7K2ZT06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_40775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001851">
        <property type="protein sequence ID" value="MYW35438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW35438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="27846" checksum="3E957E16EE41650E" modified="2021-04-07" version="1">MLARVRGAVGRTATVAGALVLAGGLGNDVFTLPGAAAAVVAAGVGLASNPKVVRAPESVRWTAISLYAAPHTGCAAILVGERLAPDGPVSVLVQAAVIALWTGATWMLRPGLTARELTDEAHAQELADAAKAVETAVAPAAPVYASAAAQWWGETFAVEGGIAPGTVLLDHQQVGEQCVALIIGTQKRGQPVPDISKPGLSAALDLPEEQIDVGPVPGRGAGVRLLVLGQRPVTEAEEGPLDSDAAVWAEIAASAMPGVELIESNTYEMPKELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZT75</accession>
    <name>A0A7K2ZT75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_40630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001846">
        <property type="protein sequence ID" value="MYW35409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW35409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="129" mass="14091" checksum="85BF607D19A21E87" modified="2021-04-07" version="1">MKIHLTSVFVDDQEKALRFYTDVLGFVAKHDVPMGGPDRWLTVVSPEDPDGTELLLEPDRHRAVGPYKTALVEDGIPAAAFAVDDVRAEFDRLRGLGVRFTQEPLEMGPVTTAVLDDTCGNLIQIAQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5U9</accession>
    <name>A0A7K2Z5U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_00140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000002">
        <property type="protein sequence ID" value="MYW27720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029466955" evidence="2">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW27720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="179" mass="18487" checksum="B41B21E5D7643F57" modified="2021-04-07" version="1">MRKPALSAAALVMVFAATTACVSGSDQKNDQPKNATTATAGAPPKVSAKELTASDAFKALSGKVASAKLSGVVTEDDDPNHLLGRPGQYTSKVTFTDSRIKVDDVTDAEPGSVELGGAIEVFTTAADAQARADYIKTVTKGMPLLAEYDFVSGTVLIRVSRYLTPTQSADYKAAAAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z5V5</accession>
    <name>A0A7K2Z5V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000003">
        <property type="protein sequence ID" value="MYW27725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="156" mass="15655" checksum="B52B9A61C8789A7E" modified="2021-04-07" version="1">MAGAVEAQLAELGLALPAVVPPLASYQPAVQSGVYVYTSGQLPMVDGKLAVTGKVGAEVTPDEAKELAKTCALNALAAVKSVAGDLDRIKRVVKVVGFVASASDFTGQPAVINGASELLGAVLGDKGVHARSAVGVAVLPLDAPVEVEVQVELVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z627</accession>
    <name>A0A7K2Z627_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_00570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000016">
        <property type="protein sequence ID" value="MYW27800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW27800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="184" mass="20531" checksum="323ED2FDCE0C97FF" modified="2021-04-07" version="1">MSAGPDFVLRPWEMSDLPLIREAAQDPYIPLITTVPSRYSDRAAEEFVRRQWDRAATGAGYPFAIVRSRDRRPVGAIGLWLRELPEGRASIGYWMVPSGRGQGVTRAALRTVTGWALRDIGVPRLQLFIEPWNTASARIAVDVGYRHEGLLRGWQRVGDERRDMAVYGLLNSDGPVDGRAVASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6L8</accession>
    <name>A0A7K2Z6L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000059">
        <property type="protein sequence ID" value="MYW27953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW27953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="168" mass="17563" checksum="0E47DD99B73D6CE4" modified="2021-04-07" version="1">MQVLQVQLEVGPDPAEVGRARRWARSRLVGSGIGDDEPLAETLILLISELVTNAVVHTGCPAVLRMLFGGGGGGSGTVRVEVADASDRPPLQRHAEGEDTNGRGLELVDGLADRWGWQPEGAGKQIWCEVDRGAPAAVVQDAPPRVVVQGGEVCEPPSCVFTNAPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6R9</accession>
    <name>A0A7K2Z6R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000068">
        <property type="protein sequence ID" value="MYW28003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="7404" checksum="505226F6DBA9A4D9" modified="2021-04-07" version="1">MDEDTHPPEQPAAGPVVCARCGTAAKGDTAPVTWLSSVEDGRRLHFCESCARLHIRAIESRLDSLWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6T2</accession>
    <name>A0A7K2Z6T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2771 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_01870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000081">
        <property type="protein sequence ID" value="MYW28050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029447193" evidence="1">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="159" mass="17021" checksum="A315BB9FE9C0C10F" modified="2021-04-07" version="1">MTVAFFSGKGRRIGVALGAVSAGLLVLSACDKPTPLATVTVGTTSVNSEAACYNDGEAIKESLIQGCLNKKPEKTLEVAMDDKVRFGVDPEIADRGWTLFINGQQAEQEPFKKTYRTIPGSAFFASQTGEPASKTNVSIVETNGKKLTGIWQFELKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6U3</accession>
    <name>A0A7K2Z6U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_01830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000078">
        <property type="protein sequence ID" value="MYW28042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="134" mass="14483" checksum="D2A5710179BEF2A5" modified="2021-04-07" version="1">RGDLADPVPGRMYDLVLSNPPYVPSPLGPPPRRGNARAWDAGHDGRAVVDRICDAAPYLLHRGGVLLMVHSDLTGTEATLRHLSGGGLKAEVSDTASVPFGPVLRSRLPWLRGRGLLDEHTDEEKLVVIRAEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6X1</accession>
    <name>A0A7K2Z6X1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000100">
        <property type="protein sequence ID" value="MYW28097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="174" mass="18868" checksum="EBD7375EFA2791C7" modified="2021-04-07" version="1" fragment="single">MTVDSASERRFERALASLRGLSVGDALGSQFFVPVNYPLLKQRLLPPGPWQWTDDTEMASSVLAVLAAHGRVDQDALAHSFAEHHDFDRGYGPAVNRLLRLVREGGDWRELASGLFKGQGSWGNGSAMRIAPLGAWYADDPEQATHQAEISSYTTHQHREAVVGAMAVAAAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6X2</accession>
    <name>A0A7K2Z6X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000099">
        <property type="protein sequence ID" value="MYW28094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029473388" evidence="1">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="122" mass="12472" checksum="9C9053E5035850D9" modified="2021-04-07" version="1">MAARLLVVPLLAGLVLLIGAPTTAAQAAPGCSGRPAKTITFATGELRVYKSRAHACAVTVAKKPGQRRTMSVTLQPRGGRVVKDSGSFTQMAGPVTVNALNRCVRATGAVAGRSAATGWILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z6X4</accession>
    <name>A0A7K2Z6X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_02080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000099">
        <property type="protein sequence ID" value="MYW28091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="27"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="219"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="407"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="560" mass="59012" checksum="752F35AF84D8FF63" modified="2021-04-07" version="1">MSHDHDDRPQLTAAQAAAVLTPPPGRNGGDLVVESLQGLGATTVFGLPGQHALGMFDALRRSSLRYVGLRVENNAGFAADAYGRITGEVAPLLLSTGPGALTSLAALQEAAAASAPVLAISSQIPTAGLGGGRHGYLHELRDQQASVRDIVKSVHTVRAASQIPSAIAAAWESALTAPHGPVWVEIPQDVLLAETTLPVVSAMDATPRELYPRPELTIAAAHLLSNAERPVIIAGGGVVRSDASGKLRALAEKIDAPVVTTFGGKGAFPWEHPLSLRSWLEDRHTTDYLEDADVLLVVGSGLGELSSNYHTFRPRGRVIQIEADAGKLESNHPALGIHSDAREALSELLETVERREDAGAAQRVVTVLEKVRVRIDAQELTLEQQVLDAVRQALPDASPSFWDMTILAYWAWSAFDARRPNTMHSAQGAGGLGYGFPAAIGAASADPTTPVLAVSGDGGAMYSIAELATARQYDLPLTWLIVDDGGYGILREYMTGAFGEATGTELSRPDFVVLAESFGVPAVRTTPESLAADLGKALAEPGPSVVVLPALLRMFEPTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z709</accession>
    <name>A0A7K2Z709_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type VII secretion protein EccCa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eccCa</name>
        <name evidence="6" type="ORF">GT040_02175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000101">
        <property type="protein sequence ID" value="MYW28108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="450"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="816"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="1105"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="473"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="834"/>
            <end position="841"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW28108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="1324" mass="142961" checksum="8492F87D0BEA8EF0" modified="2021-04-07" version="1">MSQIVVKRPPRALPSEVPVEQVQLQSPPELPRGQQEGMLMQLLPMLGMGGSVVFFFMTDKPIMRIMGVIMIASTVAMAIAMMVRFRRGTQGQLADMRRDYLKYLTQTRRTVLKTARKQRDAQFYLHPSPEQLWALVAEGSRVWERRVADADFAQVRIGLGSQELATPLIAPETAPVEELEPLTAGAMQQFLTTHSTLDGLPMAVSLRAFYHLTVGGHAESARSSARAMVGALASLHSPEDLVIGIAAGAEAAPQWEWAKWLPHVQDKGATDGAGSRRLITGSVLELEQQLAARLDGRPRFQPGGQPLLEQPHVVIVLDGDSVPPMSVLASAEGLQGVTVIEVVPGEVQGARGGLSVVVQPQSLQLESGQGLVYEGVPDLLSYEAAEALARQLAPLHMATGGDDDEPLLANLEFTDLLNLGDAASIEVSRTWRPRAQAERLRVPIGVGEGGAPVMLDLKEAAQEGMGPHGLCVGATGSGKSELLRTLVLGLAVTHTSETLNFVLADFKGGATFAGMAQMPHVAAVITNLADDLTLVDRMGDSISGELNRRQEMLRDAGNYANIHDYEKARAAGAPLQPIPSLVLVIDEFSELLTAKPDFIDMFVQIGRIGRSLGVHLLLASQRLEEGRLRGLETYLSYRIGLRTFSAAESRAAIGVPDAYHLPNVPGSGLLKFGTEEMVRFKAAYVSGVYRAGGQPVASGGPLPVDRRPVPFTAAPVPVRYVQPSPQAGAGVPDQRAGDDDALADTVLDVIVRRLEGRGASAHQVWLPPLDNPPSLDEILPGLTAVPGRGLTQPGFEGAGRLVVPLGVIDKPFEQRRDTLYRDFSGAAGHMQITGGPQSGKSTLLRTLIAGFALTHTPQEVQFYGLDFGGGGMSSIAGLPHVGVVASRLDPERVRRTVAEVYGILSRREEYFRSAGIDSIATFRRMRARGEISVTDQPWGDVFLIIDGWGNFRSDYEALENAAVDIAARGLGYGIHLIVTASRSMEVRASLKDHLMNRLELRLGDVMDSELDRKVAVNVPAGVPGRGLTPEKLHFMAAVPRIDGINSDSDLSEATAAMNAEVARHWTAPPAPQVRLLPRSLPASELPAGHAAPERGIAFGIDENNLAPVFVDFDHDPFFLIFGESESGKSNLLRLLIKQLTERYDGDTCKLFVIDNRRSLLDVTPASHLAEYIPMSNNMDHHMVALHDLMKRRTPSADVTAQELRDRSWWRGPTVYVIIDDFDLVATSSGNPLSSLTELLPFARDVGVRFIIARNTAGASRALYDSFLQRMTELGAQGVLLSGDPMEGDILGGVRPRPMPAGRGLFVTRRRGNPLVQTGLVDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z730</accession>
    <name>A0A7K2Z730_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_02455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000108">
        <property type="protein sequence ID" value="MYW28160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="175" mass="18243" checksum="E998393D927336BD" modified="2021-04-07" version="1">TAGPDGVARPVVLVGADTGAVAVAALLGSGESAAADAVVLAGLPARTAASADWDDELDVRTFCPAHRSRLSGDSGFRRGALDEVVPEALLTAAYESEAEVPALILTGDADLLADRDALTRTAKSLPRARLSIVRDAHHDVLNDMQHRSVAAEIVTFLEALRNELVPLVTVESTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z7J7</accession>
    <name>A0A7K2Z7J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_03160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000145">
        <property type="protein sequence ID" value="MYW28293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW28293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="201" mass="21827" checksum="B116A1C9D4C58CE6" modified="2021-04-07" version="1">MMRTERACNWCEGDMPLTARADARTCSTRCRVALHRAAKRNTLPIELTTRDRWIRRSATKVPLTTGDMPASSTDPRTWSSYKDATASSAGVGLGYVLSDVDDIVCLDLDHCLNPLTGRLAPWAAAIIRDAGATYVEVSPSGDGLHIWGRADVRQGRRIRRPDGTAVEVYGTGRYIAVTGRRHGSCPSILADLSAVVTKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z865</accession>
    <name>A0A7K2Z865_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_04310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000196">
        <property type="protein sequence ID" value="MYW28512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029723181" evidence="1">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="274" mass="27972" checksum="067062C8EDEFA641" modified="2021-04-07" version="1">MIARRTTRLAALLVLPAALTLGVAVPALAHEGHPAGTTKAADGDTYQIDLEQLNDSGASGAALVSLEGDKLTVKIDAQGLVPGQPHAQHIHGSTDGHDFRCPDKSADKDGDGIVTTAEGLPMYGDINISLTTKGDTSKDSGLAVDRMPVADKDGKLTYSRTITVSQDVADHLKDLHIVQHGIDRNSDGKYDFGAGKSELDPKLPQEATAPANCGMVKGAAVGSVPAGGVETGGGTTEGVESPGMLAAGGAAVLAAGGLFAVRRRTRTSDAGHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8F0</accession>
    <name>A0A7K2Z8F0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ORF">GT040_04870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000213">
        <property type="protein sequence ID" value="MYW28616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030561026.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000213.1"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="446" mass="46326" checksum="D2DCF03508711120" modified="2021-04-07" version="1">MTESSVHPALWPAPHASGAVDATVTVPGSKSVTNRALVLASLASEPGWLRRPLRSRDTLLMAGALRAMGVRIEETISSSSTVAGEPGGSGEAWRVIPAGLHGPVTVDVGNAGTVMRFLPPVATLADGPVHFDGDPRSYERPLTGVIEGLRALGARIEDDGRGALPLTVHGGGALDGGPVAIDASSSSQFVSALLLSGPRFNQGVEVRHTGSVLPSMPHIRMTVDMLRAVGAQVDEPETGGEPNVWRVSPSALLGRDLTIEPDLSNAQPFLAAALVTGGKVTIPDWPERTTQPGDALREIFTAMGGSCELTERGLTFTGTGRIHGIDVDLGEVGELTPGIAAVAALADSPSTLSGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRPLHGGVFHTYDDHRMATAGAIIGLAVKGVEIENVGTTAKTLPDFPDMWTGMLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8S7</accession>
    <name>A0A7K2Z8S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GT040_05550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000250">
        <property type="protein sequence ID" value="MYW28747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MYW28747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="383" mass="40771" checksum="84A9615EB3DC4BE9" modified="2021-04-07" version="1">MNLELSQEQEAVRRLAEEFVAREVTPHVVAWDRAENVDRSIVKKLGALGFLGLTVPEEYGGSGGDHLTYCLVTEELGRGDSSVRGIVSVSLGLVAKTIASWGSEEQKRQWLPRLTSGEAIGCFGLTEPGTGSDAGNLATRAVRDGGDYVINGTKMFITNGTWADIVLLFARTDDTPGHRGVSAFLVPADTPGLTRRTIHGKLGLRGQATAELVLQDVRVPADTLLGPEGKGFTVAMSALAKGRMSVAAGCVGIAQAALDASVRYAGEREQFGKGIAGHQLVQELLSDISVDVEAARMLTWRVADLVDRGQEFATAASQAKLYASEAAVRCANNAIQVFGGYGYIDEYPVGKLLRDARVMTLYEGTSQIQKLIIGRALTGVSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z8W2</accession>
    <name>A0A7K2Z8W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (Decyclizing)</fullName>
            <ecNumber evidence="7">3.7.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iolD</name>
        <name evidence="7" type="ORF">GT040_05750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.22" evidence="7"/>
    <dbReference type="EMBL" id="WWKE01000253">
        <property type="protein sequence ID" value="MYW28787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102481">
        <property type="term" value="F:3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04377">
        <property type="entry name" value="myo_inos_iolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="100"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="267"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="466"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW28787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="678" mass="72171" checksum="E0A08A8B87D0D24F" modified="2021-04-07" version="1">MSPTSPASPPSPVSARPARTRRLTTAQALVAFLARQYTERDGRRHRLISATWGIFGHGNVAGIGQALVEAGNGTWNGDGTRNGNGNGNGHGNGDGHGTRTRPRMPYLQGRNEQAMVHAAVGYARQSGRLSAHAVTTSIGPGATNLVTGAALATINHLPVLLLPGDTFATRPADPVLQQLEVPYAGDVSVNNCLRPVSRYFDRVARPEALIPAALQAMRVLADPAETGAVTLALPQDVQAEAYDWPEEFFAERVWRVRRPAPDMAELEAAVRAVRSARRPLIVAGGGVRHSAAEETLAAFTAATRIPVASTQAGKGALRHDHPADVGGIGHTGTATADELARTADLVIGVGTRYTDFTTASGTLFQNPAVRFLNLNITGFDAHKLAALPLVADARTGLEALTSALAGRGYRIDPAYETEYTGAKEAWEEQVEASFTTPDPTARPTQTQVIGLLDTLVTEEDILINAAGSLPGDLHKLWRTRSRDQYHVEYGYSCMGYEIPAAIGVLLATEAQGHEGRPVWALVGDGTYLMNPTEIVTAVQENLPLRLLILQNHGYASIGGLSEAVGGERFGTAYRHRDPVGGFTGPPLPVDLAANAASLGMRVLRATTVDDLRKALAEARSAEGPTCVYVETETPDTVSGPPPAQAWWDVPVAETASRPAAVTAREEYDRRVAARRHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z922</accession>
    <name>A0A7K2Z922_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M23 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000265">
        <property type="protein sequence ID" value="MYW28851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="313" mass="32194" checksum="65069AB6172C5AFF" modified="2021-04-07" version="1" fragment="single">MNDQHPHAGPVGYDTRSTGSFDTDPLFGSLPGGSETTDYAASGYDTSYGAPNAPYDSSAWDTGAQQTVAYDAYAAPAPSTAHQQWDTGATPTWQQPSAQDPAAQWPATDTGAFPTAGFTEAAYGTAPYGTGAYETDGYDTGTYATGTYGTGTTHDTGAYGTGTYEAGTYDAATYDAATYETGAYGTVGADGTGAYDTTAYTTGVYDTGAHDTGTYDTGTYDATAWNSGATPEDAAYEPEQTSHQLYEQREPEEGGTAEFAVIDAGHATDVDDGHETRHESPHATGLASDAATTPDDDGDAPGPAPLSADRTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9A2</accession>
    <name>A0A7K2Z9A2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_06435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000298">
        <property type="protein sequence ID" value="MYW28919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="41"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="532" mass="56690" checksum="C3493A2CD5A48CF1" modified="2021-04-07" version="1">MTTEHTTRPTTGCGPALPGSITPALLRRLTALVPAAPDAVRFTTTAPYTGLPLADLPVSTPDDVEAAFARARVAQKAWAATPLSERKRILLRYHDLVLARQDEALDLMQAENGKTRRDAFLEVVDIGVTSRYYARNAAKYLSPKRRRGAIPLLTHTTELRHPKGVVTVISPWNYPLSMAAGDTIAALMAGNAVVQKPDTQTALTALWSMDLMYEAGLPRDVWQMVIGRGSSIGTPLMDNADYMMFTGSTPTGRQIAADAGRRLIGASLELGGKNPMIVLDDADIEKAVEGAVAACFPSAGQLCVSVERLYVAESIREEFVAAFTARARKLTIGAAYDYSVDVGSLTTPAQLKTVTEHVDDAVAKGATVLAGGTARPDLGPLFHEPTILTDVTPDMTLYDHETFGPVVSIYTYRDVDEAVALANATSYGLNASVWSRNGARGRAVAARVHAGTVNVNEAFAAAWGSVDAPMGGMGDSGLGRRHGADGILKYTEPQTIAHQRIQGFTPPARISPTTWAALLTGALRLLKSAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9B5</accession>
    <name>A0A7K2Z9B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GT040_06565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000300">
        <property type="protein sequence ID" value="MYW28944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW28944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="495" mass="51174" checksum="4B4CB158595AE142" modified="2021-04-07" version="1">MTGRAWGVLFVLCGAIFLEGIDVAMLNVAMPAIRADLGLSTGTLQWVMSAYVLGYGGFMLLGGRAADLFGRRRMFVLWLVVFLLFSGLGGLATEGWMLILARFVTGVSAAFMTPAGLSIITTGFPEGPQRNKALLVYSGTAAGGFSIGLVVGGLLSAIDWRWVFFAPVILSALILVAALRLVPKSPRPDRTGQGVDLAGAVTVTGGILLLVFGVERVAHASAAWTTGTIGTALLLFLAFVLIERRSASPLVRLGLFRSGSLVRANVAGLLFAAGFFGFQFIAVLYLQELRGWSSLQTSFALIVIGLDAILSPLLTPKLVARFGNARVIFGGLLLASLAYALFLPLGADWTYLAMLPSLVLIGVSFSLAYGPLTITATDGIAEEEQGVAGGLLYTSFQFGAALGLSSVAAVNIAATEGTSTGALLDGYRAALVVPLAAALIATAVSAFGLRRRSASPSEGAHEGPSEGPYGGADGPSAAAPESVRQADLPSGKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9D0</accession>
    <name>A0A7K2Z9D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_06700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000302">
        <property type="protein sequence ID" value="MYW28970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="234"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW28970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="330" mass="35791" checksum="250BC739E5F7761A" modified="2021-04-07" version="1">MGHATTDRASAGPRRITLERIESYVPERSVRIEELGERLGLHRAQLGVFRKFYGLDTLRFDPELPLLDLLRPAARSALAALPEGGRVGYLAYAHTTQAVAPPGVDIAQVVGEDLGLPEAGAFGFSHQACVSSLGAIEVLGELLRAEGEEGAYALMVTGEQAYSPMVQHIPNTSIMADAAASCLITLDGEGDVVRSFAIRTLGEYAQWLELTPEQNTEFGEQYGRRIADVIHEALKEAGLSLDEVDLVIPHNVNRLAWRQTIKELEVEPEKVFLDNVPRFSHTYASDVFVNYTTLRDAGRLVDGAHYLLVSVGLGATFGAMVITHRAGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9M2</accession>
    <name>A0A7K2Z9M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_06725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000303">
        <property type="protein sequence ID" value="MYW28975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029457257" evidence="3">
        <location>
            <begin position="36"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="421"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW28975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="526" mass="55489" checksum="B845896153DB1DFF" modified="2021-04-07" version="1">MRAHRRVLQTGAALLTAGLLAGCGLLSTEPEPSDRADGRPGGSSAPPPPGLKETPKTPPLPAALTSQRPDWKRCTAPSGGSAPGSDWRCTSVDVPLDYTKPSGETIAVALIRKQARDKDRRLGSMLFNFGGPGGSGVEILPRAASSYEKLNSRYDLVGFDPRGVAASSGVNCRTDEEQEQALRSVDLTPDTAAEEAAFIKDGADFGAGCQRRSGKVLPHVGTSNAARDLDLIREVLGDDKLSYFGFSYGTELGGTYAHLFPQNVGRTVLDAVVDPTADGTGHARSQATGFQRALENYLKDRGENPKAGSERIARMLARIDRKPLPTASGRELTESLAVTGIVTPLYSQSGWPALTAALDEAENKGTGDGLLQLADSYNGRDEDGRYDTQAHSQRAISCADSKSRPTVDEARALLPEFRKLSPVFGPFLAWDTAGWCAQWPVDGEHETPETSAPGAGPILVIGTTGDPATPYEGARRMADELGKGVGIMLTNKGEGHGAYGESDCVTAAVDGYFLDGKVPEDGTTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9R4</accession>
    <name>A0A7K2Z9R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_07350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000335">
        <property type="protein sequence ID" value="MYW29096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="335" mass="35431" checksum="D0CF814CC9D59B4A" modified="2021-04-07" version="1" fragment="single">AAYVIYTSGSTGRPKGVVVEHRSLSNLLEHHRQEAHALAEEALGRRLRVALSAATSFDAAWDPVLWMVAGHELHIIADDVRRDPQALVRYLVDHRVDAIETTPTYLRQMLAAGLLTSESHRPRVIALGGEAVDDGLWEELAADPGLLVFNFYGPTETTVNAVTARITGASPVIGRPVAGAGAYVLDPSLHPLPKGSVGELYLSGEGVARGYAGRPGLTAERFMPDPFGLPGARMYRTGDLARWGEDGSLEFVGRSDRQIKVRGVRVETGEVEAALRSLPGVQDAAVALTGAPDGPERLAAFLVAGTAGAPAHAETRDAVAALLPGPLVPTAWATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2Z9Y8</accession>
    <name>A0A7K2Z9Y8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_07650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000356">
        <property type="protein sequence ID" value="MYW29154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="27"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW29154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="279" mass="29688" checksum="C25DA22455FBDAA5" modified="2021-04-07" version="1">MTTVEKSPAVTGGGREHGLAYWAVSDCWNITRRTLTHYQRHPSAIVWQLGFPILSVLLYGYVFGSAMKVPGGGDYREFLMPGMFAMTMAMGFMNTAVAVVTDAGQGVVDRFRSMPMAPSAFASGRGVADLVVAAAELTILAVTALLIGWRAGGGVMPALGAFGLLLLLRFSLIWVGVWLGLLVPTPEAAGGLYAVAFPLTMISSTFVAPSLMPGWLGTVAAWNPLSSTATATRELFGNPVAGGGTWVEEHALLMAVVWPVVITLVFLPLAVRRFRLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAK0</accession>
    <name>A0A7K2ZAK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000403">
        <property type="protein sequence ID" value="MYW29359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="105" mass="11717" checksum="455E6CBE22E97871" modified="2021-04-07" version="1">MFMCRRNPPGNPPMDPSGAIVRSVALRMIRRLADQPELVRPLSTVVELVDHDEADLALDDIVMVIEFSPFPVLRSEYEDLRRAAQQLDSLDSLTDTGVELLVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAL1</accession>
    <name>A0A7K2ZAL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_08770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000404">
        <property type="protein sequence ID" value="MYW29369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="69"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW29369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="258" mass="27556" checksum="4465229DE5FCD1AD" modified="2021-04-07" version="1">MDETADPVPAAGHPGFPAHHAASCTALGELDALVTHCRACPRLVTWREEVGEVRRAAFRDQEYWARPVPGFGPADAKVAVVGLAPAAHGGNRTGRMFTGDATGDFLFAALHALGLASQPSSVHAGDGLRLHGVRLTSPVHCAPPENRPTPGERDTCRPWLAAELNLLSPRLRSVVVLGGFGWQALLPVLAQAGWEVPRPRPAFGHGARVVLHATGSRQELHLLGSYHPSQRNTYTGRLTMPMLVNVFREAAAIARIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZAL7</accession>
    <name>A0A7K2ZAL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_08820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000406">
        <property type="protein sequence ID" value="MYW29379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="32077" checksum="5844DBB465310D05" modified="2021-04-07" version="1">MSLAPRAVLVHRRTEYEELLARHGTHGQAAFFLSSRGRAIDEVARRHERTQQALRDVAAAVPLTWRSTRVERADLDRFLFAPEDVVVVVGQDGLVANAAKYLSGQPVVGIDTDPGRNPGVLVRHRRTDAAALLRAATATGSTVDALTMVEAVADDTQRLVALNEIYLGPPGHQTARYRLGPDGDPAPGEAQASSGVLVGTGTGATGWLRSLWLERGSTTPLPEPSDQRLLWFVREAWPSPATGTSLVSGELGRGQGLRLTVESDRIVVFGDGMEADALELTWGQSVRLGISATALRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZB31</accession>
    <name>A0A7K2ZB31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_09400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000424">
        <property type="protein sequence ID" value="MYW29485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="78" mass="8300" checksum="D25DE0CD8D538A6C" modified="2021-04-07" version="1">MSSTLRWFKSSYSSSSGGDCIEVAFDWRTSSYSSGSGGECVEVAACPHAVHVRDSKVTDGPTFAVAPDAWSAFVTWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBA7</accession>
    <name>A0A7K2ZBA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamide-nucleotide amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_10240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000468">
        <property type="protein sequence ID" value="MYW29646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW29646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="172" mass="17424" checksum="5D076440977217EE" modified="2021-04-07" version="1">MTAAAVAARALELLVERGETLAVAESLTGGLMAAELTSVPGASRSFRGSVTAYATALKGEILGVDGTLLAERGAVDPEVARQMAAGVRRALGADWGVSTTGVAGPEPQDGQPVGRVYVAVAGPSGVEKVSALRLNGSRADIRRESVRSALDLLAGELGENARAQDTEQIGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBE2</accession>
    <name>A0A7K2ZBE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000484">
        <property type="protein sequence ID" value="MYW29691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="18162" checksum="8F5472840F5D0CD0" modified="2021-04-07" version="1">MQMTITYPGGHQEIEYVDHADPGGVFGPILRRRREERTRKAQAQRDSRLLQLSRDIEALEAWHHAWRLEWDVDYREMHPGQWCERHGKLLKSCYCNSHYRRFTERPYTEPYEIRTGDGTIIRRRPVQHVASVLTTEERRAATRTMAKWGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBX7</accession>
    <name>A0A7K2ZBX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2797 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_10900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000494">
        <property type="protein sequence ID" value="MYW29775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021246">
        <property type="entry name" value="DUF2797"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10977">
        <property type="entry name" value="DUF2797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="299" mass="31722" checksum="C5CB900257716374" modified="2021-04-07" version="1">MAFGWRCTGVAWPGDVPRLGWSKAAERRVSTLAYGVGLGFRVVGERHCVGARGNVCPLGAVVSVRSTGARCPECARLDRAHSVAADTLLDDPRTYRVYLAWFGPGLVKVGITREERGAARLREQGAVVFSWLGRGPLMAARRTEEVLRAALGVPDRIPYARKRAVRGRLPGERERFGEVVELYGRAAELEGRGWPESLERLPLDVVDHGGIFALDRAPRATRSVRELVDGGLVAGELVAAAGPDLHLAVDGGGGGGGVVVLDTRLITGWELAAVDPAAANDVRVPLIDIAGGGVQGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZBZ7</accession>
    <name>A0A7K2ZBZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GT040_11000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000499">
        <property type="protein sequence ID" value="MYW29795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="87"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MYW29795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="254" mass="27220" checksum="B59A5EC5B54B9CE1" modified="2021-04-07" version="1">MIDLRRLDWRASAGRVRDSAAGGTVGGAPVTYGLIALCCAIFLISPLSGFGGASYGSQDALLAAQAGYFERWGVIPAELWEGSARALLTPFTALFVHGSWLHLLGNLLFLYVFGAMAEERMGRVQFALFYVGCGYLALVCYAAAHADSEQTLVGASGAISAVLGAFLYLFPKARVTSLFPFLFFLPLRFPAWIVLVFWFGLQWAAAQAADAGPGVAYLAHVAGFAAGFLYAWGRYGRRARVKVPATATEGDRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC36</accession>
    <name>A0A7K2ZC36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_11220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000506">
        <property type="protein sequence ID" value="MYW29835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW29835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="15490" checksum="5A472BC812140EE9" modified="2021-04-07" version="1">MTFDKEWAELRTAAAERIATRINGVPSEGGEGGGGGAPDLVVHRDDLGAIGNDAYDLRTRLSKEGDHARPATFDAAIALTNGNFASGAAVLKVHDRWQTQLKTLLDSCAHISNHLDYTKAQHAKDEVKVVGDLPPISKLTEYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZC87</accession>
    <name>A0A7K2ZC87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_11665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000545">
        <property type="protein sequence ID" value="MYW29922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024195">
        <property type="entry name" value="NUDIX_hydrolase_YfcD_pred"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017340">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017340-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW29922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="169" mass="19437" checksum="A14FE0B7ADBE71D9" modified="2021-04-07" version="1">MTPSDEILDIVDERDEVIGQAPRGEATARGLRHRCVFIEARDAQGRLFVHRRTATKLVFPSHYDMFVGGVVGAGESYDEAALREAEEELGVSGLPMPEPLFRFLYTDEKHSWWSAVYQVRCELPVAPQAEEVAWHTFLDEEELEERLGEWPWVPDGLEAYRRLRTYRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCN1</accession>
    <name>A0A7K2ZCN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Uricase</fullName>
            <ecNumber evidence="5 7">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pucL</name>
        <name evidence="8" type="ORF">GT040_12620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>H2O + O2 + urate = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 7"/>
    <dbReference type="EMBL" id="WWKE01000597">
        <property type="protein sequence ID" value="MYW30104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="PTHR42874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MYW30104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="307" mass="35264" checksum="B20835E7087D5331" modified="2021-04-07" version="1">MPTILGQNQYGKAENRVVKITRDGDTHHIKDLNVSVALSGDMDDVHYSGSNANVLPTDTTKNTVFAFAKEHGIESAEQFGIHLARHFVSSQEPIHRARIRIEEYAWERIATSDGNSKFIGADEVRHSFARKGMETRVSQITYDGENWEVISGLKDLTVMNSTNSEFWGYVKDKYTTLKEAYDRILATDVSARWRYNWTSDEQRMPNWEKSYEQARKHMLQAFAETYSLSLQQTLYQMGSRIINSRSEIDEIRFSLPNNHHFLVDLEPFGLKNDNEVYFAADRPYGLIEATVLRDGVEPKIPVDMTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZCN5</accession>
    <name>A0A7K2ZCN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PBS lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_12440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000583">
        <property type="protein sequence ID" value="MYW30068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="203" mass="21911" checksum="914C8C1BFE13F5FF" modified="2021-04-07" version="1" fragment="single">MFSGIDEVDWASMEHAYGPADDVPVLLRGLASADPAERESALDGMYGAVHHQGDVYACTLACIPFLFELAVDPDVQDRGSVVELLTSIGGFDLDEDDDEIDEDEIEGAANYAMAAAAVTAGAGVFFELIADEDPGVRLAAPLALATLHRHPVRVLDLLRERLPAEPDEEVRLALVEAAGRVALRHRPLAGRVVEWLTLLVDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD50</accession>
    <name>A0A7K2ZD50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_13575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000646">
        <property type="protein sequence ID" value="MYW30290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="67" mass="6696" checksum="9687C8DC53DDE543" modified="2021-04-07" version="1" fragment="single">TGIAGADGLAMLRDAVKMGAAVVGGCPDLDPDPTGYTAAVLEVAAEHGRPVDLHTDGDDPARLARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZD53</accession>
    <name>A0A7K2ZD53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3515 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_13635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000651">
        <property type="protein sequence ID" value="MYW30301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029469627" evidence="1">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="158" mass="16555" checksum="81FA1F72AB252EDD" modified="2021-04-07" version="1">MPSKRTTLPLAAAAVAVAAVLVFVVTKEPHYNVRPGAQSGNAHCGRIAENAPAELAGHTKHATKLAGVALWGDSNIVLRCGVTDIGPISDPCFSADGVDWVIDTTRSTDTRKVIITYGRTPATEVTVTHSPKAPDEILGELSALIAPITQTSECTRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZDP6</accession>
    <name>A0A7K2ZDP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_14650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000688">
        <property type="protein sequence ID" value="MYW30487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW30487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="453" mass="48373" checksum="772A15DB0D3C4CFD" modified="2021-04-07" version="1" fragment="single">AVAGSGVPGPDDLPPALGSVHRFPFGSPCAIALRSGHVEAVPGDDMGFVQSTLAVPMVAHDTVVGLVQFSRTKGSEPFGERDRVLATELAARAAVCIDNARLYRREHERALILQRSLLPPGDPEAAGLDIACRYLPGNTATEVGGDWFDVIELPGHRTALVVGDVMGRGLRAAVAMGELRTAVRTLALLDLEPAEVLSALDEVARGLGSPGGGERSEGLGGSGGAQWPSRAAQKSREADLSEVYLATCVYAVYDPVTRRCTFANAGHLPPAVVEPGRPARLIDVPPGMPLGVGGEPFEEVEVELAENALLTLYTDGLVESRDQPLDEGLDALRAVLTGPQMPLEDACDFVLSTLDTRHGEDDIALLMARIQGLPEEAVGDWTLPREPRSVGRARELARSQLMAWDLDDLVDTTELLVSELVTNALRYGEGEIRLRLLRDRTLVCEVWDAGLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEF5</accession>
    <name>A0A7K2ZEF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sel1 repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_15955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000748">
        <property type="protein sequence ID" value="MYW30731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="177" mass="18770" checksum="CA6D2DAAEB33CE1C" modified="2021-04-07" version="1" fragment="single">EPGAEYWLRQSAEQGHALGAYALADLLEHRGDIGAERWLRAAAEQGHREAAYRLARALERNAVEDPHDAFGLGRGTGRSGLGLSADPAVPDALKKGERGTEENKGGAAGDSPVAGPAAGRIGEAEQWYRRAAARGHRRAALHLGAILEQRGELKEAGRWYLTAAKDGEARAACALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZET7</accession>
    <name>A0A7K2ZET7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000770">
        <property type="protein sequence ID" value="MYW30863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="273" mass="28386" checksum="30DDCB01C7D63C04" modified="2021-04-07" version="1" fragment="single">MTDRTTSGTDLPGRGRELASLAALHAEQADRESQLPPVMVEQIVAAGFARHFVPTRWNGRAGSVTDLFHAVSAVAEGCTSAAWSASVIASAGRMGAFLPLEGQQDLWAKGADTLVVGALMPRGDATPVPGGWRVSGSWSYASVVDFSDWALVCALVTVDGHQVPWFFALPREDYTVTATWASTGMRGTGSNSLAVEGVFVPEHRGFTRQNMIAGHGVGSDAPCHTAPLRLVSGLLFGAPAVGAARSALRAFAELSAPVAPDNPAPRAALARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZET9</accession>
    <name>A0A7K2ZET9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_16730</name>
        <name evidence="6" type="ORF">GT040_38010</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000773">
        <property type="protein sequence ID" value="MYW30874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWKE01001725">
        <property type="protein sequence ID" value="MYW34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW30874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="214" mass="23073" checksum="0B028FDCF2933AA3" modified="2021-04-07" version="1">MADKIIRVLLVDDHQVVRRGLRTFLEIQEDIEVVGEASDGAEGVARTEELRPDIVLMDIKMPGTDGIEALRRLRQLDNPARVLIVTSFTEQRTVVPALRAGASGYVYKDVDPDALAGAIRSVHAGHVLLQPEVAGALLAQDDAGSGTGRGSTLTEREREVLGLIADGRSNREIARALVLSEKTVKTHVSNILMKLDLADRTQAALWAVRNGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZEZ5</accession>
    <name>A0A7K2ZEZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4243 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000775">
        <property type="protein sequence ID" value="MYW30879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="276" mass="30208" checksum="43D8FB2FAE86B382" modified="2021-04-07" version="1" fragment="single">MTDTQRYPTDTSGTLDEALERIHLSGPERDGWLSNHAPMAIEALVRHGHARVAHRWLDTYRPKLEDMPGSVAPVTALNWQEALGDISRVADWTAFFERETADRPWRTVLAEWWPRLLPGIAAGATHGVIRVGHAVRTLLEGEETAPRVRELAHALGYWAARRQPLPALEHLAPAPDAAAALDRVPLIADQDGGIRSRFEQLTGFPDWPGRAPSGPEAARAAIEELVRAATHRYATHGHADPIMLVHAATAPNAVLRTLPALPGTLWTPSLHAAWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF26</accession>
    <name>A0A7K2ZF26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Primosome assembly protein PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_16950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000796">
        <property type="protein sequence ID" value="MYW30918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW30918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="131" mass="14114" checksum="D8E5EA16B9E64B92" modified="2021-04-07" version="1" fragment="single">HALLTADSGPEKRYRQWLAVRRGSVRAVVGTRAAMFAPVRDLGLVVVWDDGDSSHSDTNAPFPHVREVLELRAALGRCGFLLGSTSCTVEAAQLVESGWALPLIADRERLRRAAPLIRTVGDGELARDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZF60</accession>
    <name>A0A7K2ZF60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000812">
        <property type="protein sequence ID" value="MYW30994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="171"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW30994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="495" mass="52056" checksum="C7617FFB46679383" modified="2021-04-07" version="1">MTSAGRLPLLLEAVLSIGSDLGLRATLQQIVDTATTLTGARYGALSVLEPDQDRTEALYTTGMTEAERQRVGRLLPERRAALPPEEGRKAPPAPAFLTAPIQVHTQLFGHLCLAEKSSGPFSETDRALLHVLASQAGIAIGNARLYESARQRERWIEGAAAVTTALLTGTDAADALMTVAESARVLAGASAGVILQPTEAGGMEIVTASTLDDPAGIVGATIAPGSPVLVQLLGGEPVFIEDSATDPRMTTDVRSRFGPSMMLPLQSGGRLIGTLALPRRRGAPPYTAVDRLLATQFASQAALALVMADAQADRERLAVYEDRDRIARDLHDLVVQRLFATEMMLESTRRRAATEEDASELLGRAVDELDSTIQEVRTAIFALQQPPAEAPSTFRGRVLRETGGAAALLGFPPSVHFTGAVDALVGEETGRELLAALRGALAAAHRRPGVSAIDVAVDATVRLPDGRSAVRLVVADDGDDEVGGGSAAVTWEAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFM0</accession>
    <name>A0A7K2ZFM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF721 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_17745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000835">
        <property type="protein sequence ID" value="MYW31075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="272" mass="28449" checksum="9A627D342C97FE4B" modified="2021-04-07" version="1">MSGGETSGVDLARVALRAAMEAARKNGTGPKAKKQPLPVRTMRRDGREPMGLGAAIGALVTERAWELPAAGATLRERWAAIAPELAGHVAAVSYDADSGRLTVCPESPAWATKARLEQTRVIAAANKAAGRTVVRALRILPPGAAPVPGQADAVPADPAPAAPTGPARTRETACEGYRRALAAHQEVAPPRRVDPGIAAAVERQTAAMRELSRRAFPETDVAVPDDAPTPFDATRSERRRQAEVSRAAALRRARAEKAGRPMAAPQALGNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZFS5</accession>
    <name>A0A7K2ZFS5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpC</name>
        <name evidence="11" type="ORF">GT040_18325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000861">
        <property type="protein sequence ID" value="MYW31176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015611381.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01000861.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW31176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="124" mass="13063" checksum="744C6E4B4B14A19E" modified="2021-04-07" version="1">MAAELHVELVAADRSVWSGEATLVVARTTSGDIGIMPGHQPLLGVLESGPVTIRTSEGGTVIAAVHGGFISFADNKLSLLAEIVELADEIDVQRAERALERAKSDADAAAERRAEIRLRAVAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZG41</accession>
    <name>A0A7K2ZG41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000894">
        <property type="protein sequence ID" value="MYW31327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="106"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="331" mass="35076" checksum="1368C442F6DF9F57" modified="2021-04-07" version="1" fragment="single">ALIDEMRAKDMAVAHGAHMFWNPPTAFDKSVFDKIVSSHQGPSGEPLLRFSPDSDHAELIHAEPRPASQPSPSGRPESIAEDVNLFSRDTGTPDLGGTVHADGQVLHRLHTPGDGDCLFRSLLDTARSRAVPPAWAALNVAGLRTLLRDRLTGSELLTPDVEATPDPVLAVVDDLRMTALAGVGNPEARERIGQRWDRIQQAVVTEGDARQWRRILRDSGYPHLAEVAPTPADARRLGTDGLILAAAESTALWSSPFADALPLALAHTLDLDLRLVGTAPSAPASTFVTPLNPGGNGGTVHLAYNGSDHYDALIPAASLPAPTPTIPAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGR0</accession>
    <name>A0A7K2ZGR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_19990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000932">
        <property type="protein sequence ID" value="MYW31495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="333" mass="35947" checksum="68D73BC5EF60E0B0" modified="2021-04-07" version="1">MILMEQRTLGRTGRDVSVVGQGTWQLGGDWGEVEESDAFDVLDAAVDSGVTFFDTADVYGDGRSEQLIGRYLKNRPDADIFVATKMGRRADQLPENYVLDNFRTWNDRSRANLGTDTLDLVQLHCPPTSVYSSDAVYDALDTLVDEQRIAAYAVSVETCAEALTAIARPGVASVQIILNPFRLKPLDEVLPAAAAAGVGIIARVPLASGLLSGKYTKDTVFGPDDHRTYNRHGEAFDQGETFSGIDYTTGIEAAAEFAELAPEGATPAQTALRWIIQQPGVTSVIPGARSVEQARANAAAAALPPLPPLPQSTLDAVRELYDRSIRAEVHGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZGV9</accession>
    <name>A0A7K2ZGV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_20275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000956">
        <property type="protein sequence ID" value="MYW31548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW31548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="62" mass="6076" checksum="475F9A3EFD75F808" modified="2021-04-07" version="1" fragment="single">MDFASSSGGTARATTSAKIVVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH12</accession>
    <name>A0A7K2ZH12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_20535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000970">
        <property type="protein sequence ID" value="MYW31598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW31598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="278" mass="30278" checksum="6D2EDBA8307E67B5" modified="2021-04-07" version="1">MSQVPSITLNNGLEMPQLGFGVWQVPDDEAAKAVAKAIESGYRSIDTAAIYKNEKGTGRAIAASGVPRDELFVTTKLWNSEQGYDSTLRAFDASLDKLGLDHVDLYLIHWPVPAKDAYTDTYRAFEKIYADGRAKAIGVSNFHPEHLKRLLAETSVVPVLNQIELHPQLQQAEARAFHAEHGIATEAWSPLGQGKGLLEVPTVVAIAQKHGRTPAQAVLRWHLQTGNIVIPKSVTPSRIEENLDVLGFELDADDLAAFAALDEGKRLGPDPAEFNLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH44</accession>
    <name>A0A7K2ZH44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_20900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000983">
        <property type="protein sequence ID" value="MYW31670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="547" mass="58993" checksum="8474F43A0A0DE4D2" modified="2021-04-07" version="1">MDVRPQLIDALSALRDRVAAVRLPLPLPGAERARQTRVELLAQLDDYLLPRLKDPEAPLLAVIGGSTGAGKSTLVNSLVGCRVSEAGVLRPTTRTPVLVCHPDDHHWFAGVRVLPQLTRIWLPPGQAPDPDGLDDLGAGADDEANVLRVETALSLPRGLAILDAPDIDSLVVRNRVLAAELICAADVWVMVTTASRYADAVPWHLLRTAKEYDAALVTVLDRVPHQVIAEVSRQYAALLTRAGLGDVPRFTIPELPESAGGGSGLLPTTAVAPLRAWLTHRAQDPAARQQAVGRTASGLIESLNVRMPELASAVAAQYAASVRLTGVVQDAYGKEAERIRRRLQSGAVLSGDARTRWRGYPLYSAPGELLEALVDSLIALLQCAVSAADDQIRTQWSREPAAGVFRFEGAGREAGGWGPVEDIEGRIAVAVRRWRRVLEELAEEEVRQLERSVAPDPETVAALLAAALLGGRRARTAGEQLAERIGAQGALRLRDKGGHLLTTYLDQVLGGERDRRLAPLDALDIAPEPQAELIAALSVMQKERWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH63</accession>
    <name>A0A7K2ZH63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-CGNR multi-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_20965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000984">
        <property type="protein sequence ID" value="MYW31682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="2">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="206" mass="22602" checksum="490177A24D7BE494" modified="2021-04-07" version="1">MELAYYSDYAVRLVNTEEPARNKDALTSVEAVRELFGANQQAARRTAEADVTRFRSVRARLRAVFEAADGGDETLAVDLLNSLLLEFPVSPQISGHDTRDEDGRPDWHMHLADHPSNATAGYAAIAAMGLAFHLTSHGVDRLGLCEAAPCRNAYLDTSTNRSRRYCSDRCATRANVAAYRARKRAEAERTGLTAETAQPSSSVTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZH74</accession>
    <name>A0A7K2ZH74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GT040_20890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000982">
        <property type="protein sequence ID" value="MYW31668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="291"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="323"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MYW31668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="606" mass="67113" checksum="C8B84ACF6FAF1442" modified="2021-04-07" version="1">MAVNLVNVEQVSKVYGTRALLDGVSLGVSEGDRIGVVGRNGDGKTTLIRLLAKLEDADTGRVTHNGGLRLGVLTQHDSLDPAKTIRQEVIGDLADHEWAGSAKIRDVLTGLFGGLALPGFEHGLDTVIAPLSGGERRRIALAKLLIDEQDLIVLDEPTNHLDVEGISWLAGHLRTRRSALVCVTHDRWFLDQVCTRMWDVQRGTVHEYEGGYSDYVFARAERERIAATEESKRQNLMRKELAWLRRGAPARTSKPRYRIEAANELIADVPPPRDTSELMKFANARLGKTVFDLEDVTVQAGPKTLLTHLTWQLGPGDRVGLVGVNGAGKTSLLRALAEAARTQGDEQPAAGKVVVGKTVKLAYLSQEVSELNPNLRVLEAVQQVRDRVDLGKGREMTAGQLCEQFGFTKEKQWTPVGDLSGGERRRLQILRLLMDEPNVLFLDEPTNDLDIETLTQLEDLLDGWPGSMIVISHDRFFIERTTDKVMALLGDRALRMLPRGIDEYLERRQRMEEEATPSAAAAPRSSGAPAAAPAVSAQEARAAKKELQKVERQLDKLSTRETALHKQIADNATDFEKVAKLDAELRELVTERDELEMRWLELAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHE9</accession>
    <name>A0A7K2ZHE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_21440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001015">
        <property type="protein sequence ID" value="MYW31770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW31770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="105" mass="11600" checksum="DD748F6CCE1E0ED1" modified="2021-04-07" version="1">MKAFRLDELEAERAANDGAYLQFVRERNMSVGLYALDAGDLDPQQPHQQDEVYLVVSGRASITVGTETTQVGRGSVVYVPAGVDHKFHHITENLRVMVVFSPPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHH4</accession>
    <name>A0A7K2ZHH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="3"/>
    <dbReference type="EMBL" id="WWKE01001016">
        <property type="protein sequence ID" value="MYW31787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029552401" evidence="1">
        <location>
            <begin position="20"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="361" mass="37430" checksum="0C5B0C0D48F9F7A6" modified="2021-04-07" version="1">MRTALVIGTGLVGTSAALALSGRSVHVHLVDHDPESARTAAALGAGTDEPPAGPVDLAVIAVPPAHTATVLARAMRDGVARGYLDVASVKGGPRRELEAMGLDLTPYIGTHPMAGKERSGPLAATADLFEGRPWVLTPTRDTDTEVLNLALELVALCRAVPVVMDAEAHDRAVALVSHTPQLISSMVAARLEEADESAVRLCGQGIRDVTRIAASDPRMWVEILSANPGPVADVLAGVAADLEETVTALRGLHSADEEKRRAGTDAIEDVLRRGNAGRVRVPGKHGAAPAAYETVAVLIGDKPGELASIFADAGRAGVNIEDVRIEHATGQQAGLVQLMVVPSTAPVLAAALTERGWSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHH9</accession>
    <name>A0A7K2ZHH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rubredoxin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_21110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01000997">
        <property type="protein sequence ID" value="MYW31709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubredoxin_2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW31709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="40" mass="4536" checksum="EFBA23F4F106A979" modified="2021-04-07" version="1" fragment="single">MAARTKSAKDRPSYRCTECGWTTAKWLGRCPECQAWGTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZHI3</accession>
    <name>A0A7K2ZHI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_21640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001019">
        <property type="protein sequence ID" value="MYW31810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW31810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="398" mass="41681" checksum="C321FAE1B1A9C377" modified="2021-04-07" version="1">MSTQPLPLDGITVVAVEQAVAAPFATRQLADLGARVIKVERPDGGDFARGYDTAARGLASHFVWCNRGKESLAVDLKDPRGLAVVRELVTGADVFVQNLAQGAAARLGLDAATLCAAHPRLVAVDISGYGGSGPYAHKRAYDMLVQCEAGLVSVTGTAEQPVKAGIPAADIAAAMYAFSGVLAALLRRGTTGRGGPVEVSMLDALAEWMGHPLHQGMHGAPPPPRTGLAHSVIAPYDAYGTADGEQVLLSVQNDREWRRLAEQVLVRPELADDPDFATNTARTANRKRTDEVVGRALARLTGQEALDALEAAGIACARLNTVADVAAHPQLAARDRWREVESPVGPLRALLPPITLPGGPEPSMGAVPALGEHTDALLRALGMTDEQTSALRRDGVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIE9</accession>
    <name>A0A7K2ZIE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_23350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="152" mass="16123" checksum="182B9B8AB2589FEB" modified="2021-04-07" version="1">MLLSVHPRFANAILAGSKTVEVRRQRVAAPPGTPVLLYATAPTMALVGMARISSIHVASPKEVWSAHRAQTGITRREYDVYMDGAVQASGLTLEDPVSFDDPVPLSALRAAGTFHPPQSYRYLSGADLLQVSEAGPAVGGALRRVLPDAVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIH6</accession>
    <name>A0A7K2ZIH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_23410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001107">
        <property type="protein sequence ID" value="MYW32138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="429" mass="43926" checksum="3AD7A0216B88DB2C" modified="2021-04-07" version="1">MIAVRPGPPLAGTVTVDGSKNAALPLLAAAAALGRPGQISNVPASADVQAMLTLLQQAGHRLARTVGDPATVLVLGGGIGPIAPELFETAGRIRASYYLVPALLAAHGRAVLPWPGGCQIGERGMEQHFRVYEAFGDQCVVNNRGYTVVAGSARADSVSVMLPFRSRGATVAAILRAVVAGRPLRLGHPNLSPEVISVLDALKAAGWGTQATERLIALAPPAAGAPEGSVAWTVPGDKIEAGTLACALAATKGNGRIEGVRGRDVAPLVAALRWLGIPVAAQEDALTVHAENTQPTGHSLRAIASLSPGGLDADFEPALMALTLGLPGTHFFADTINPGRHSNLVPQLAVLGARIEQISPTQCRLTGPQHLIGAGVESTDIRTGSALLIAGLTARGVTTLGGLQQLRRGHADLPTKLRALGADICEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIV4</accession>
    <name>A0A7K2ZIV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_24180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001129">
        <property type="protein sequence ID" value="MYW32282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="262"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="431" mass="46783" checksum="7314AF1C5783BE83" modified="2021-04-07" version="1" fragment="single">MVRVESPPTDREVPVVRVVLPPVVLLAGATAVGVALVVPAARIPVAVCGAITTLVVAVLTVALHRRRRAMAAQRAEYEQRIAYLEHRILSHDSETVRLTKEVMPAAIRRLRVGNSPEEVMRDIVDADAANRHLPKALREQIYQVLEVIDNEEARRDSAQRAFVSVARRVQAIVHRQASELREMEDHYGRNPEVFDDLLRIDHGTALIGRLADSIAVLGGARPSRQWPKPVPLFSVLRGAMSRILEYQRVDLHSIAKVAIVGTSVEPLIHACAELLDNATRYSPPQTRVHVTAVEVQTGIAIEIEDGGVSLSEEARARAENMLAQAQAGINMNDLGESPRLGMAVVGRLSRMYQLQVSLRQSAYGGVRAVLIVPRDMITTGPAPGIAHGIGATSRPTSSLDMSQLQHVVPPPGKRKSKPKPAATGPVPSVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZIW0</accession>
    <name>A0A7K2ZIW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="WWKE01001125">
        <property type="protein sequence ID" value="MYW32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="141" mass="15316" checksum="513DC998C6E5A6FC" modified="2021-04-07" version="1">DTATDDAKQMAEEVDVKETEDLKAALGGVAGGRMPRGTAGAMKELEDKQKRRKTRTQRDSLDLALTELTGFYRDVLALQLGSRIAIANVDVQDSLDRVAESSTPAQTLRRIEAVIACRRAMDRNVAPLLAVEAMTMSLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJ18</accession>
    <name>A0A7K2ZJ18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DAK2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_24490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001150">
        <property type="protein sequence ID" value="MYW32341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="11"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="148" mass="14782" checksum="69F96278B4A190BA" modified="2021-04-07" version="1" fragment="single">MPQLPDDLDAVAVRTWCSLALEALGRERAEIDAINVYPIADGDTGTNLYLTVESAAAAVEAVFAAHETGTTAPATADAVRAMAHGALIGARGNSGTILAQLLRGMAGVLADGGDAAHLRLALTSAAAAARQAVAHPVEGTVLTVASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJC3</accession>
    <name>A0A7K2ZJC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_25000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001170">
        <property type="protein sequence ID" value="MYW32438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW32438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="414" mass="42593" checksum="6217DA6A7DC8C252" modified="2021-04-07" version="1">APDAPAPPVAAVQWPAASETDSSDVPVPVHRATDLPGTDSGGKPLPATPGAHHDDPPTTPPVRHDDRAVVAEPATAAPPDSSGDFALAAPDPRTAEPTPTPAAGTKVCVACRSGRVDPDGYCENCGHAQPRERDHMEQELGSVAAVSDRGLRHHRNEDSFAVSSTALPDGSPAVVAIVCDGVSSASRPDEASAAAASAANEALLESLPRGTHPQQAMHEAIVAASEAVNALAQDPPGSTEDEAHRHQNAPACTLVGAIMAGGLLVVGWVGDSRVYWVPDDRTSPPARLTEDDSWAAQMVAAGLMNEAEAYADERAHAITGWLGADSYELEPHTASFKPDRPGLVVVCTDGLWNYAESAEEMAAAVPPEAHRRPLHGAQVLVGHALDGGGHDNVTVALLPFAVEPQGAGSACTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJR7</accession>
    <name>A0A7K2ZJR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L,D-transpeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GT040_25820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001201">
        <property type="protein sequence ID" value="MYW32596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW32596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="98" mass="10737" checksum="4C9B0F750853371E" modified="2021-04-07" version="1">VGLGDAYDKMVDHSMRLTWSGMYAHAAPWNAKHFGRSNQSSGCIGMSDADAAWFYAQVRPGDPFEITGKDTKGVVDPGNGFGAWNLSWAAWQQRSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZJY6</accession>
    <name>A0A7K2ZJY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lant_dehydr_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_26150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001215">
        <property type="protein sequence ID" value="MYW32660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="170"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="385" mass="40484" checksum="99435BFE99B8C385" modified="2021-04-07" version="1" fragment="single">MKPPVPELLMPALPVTPLVPAHDGTHDGHPVPLPRVAPGALVRTTLLSLPAEPAPAAAFRAALAELVVLEGRLAALAPALGDALYASRAGHTEDFHREVVLPLRRAVHNGREPRLTLLRRLDGLAGRVPELRAWLDARGRREDVLAVLRAGTDPALAAGRSVLAGLCREPSFLRAASFTSADLLRAVLRAGHGPTDRRARKEEAGVARHAVRAVARTTPLSAFTAVGWGVLPTPSAVDRGDVSWNGADLPVGSSRAVVRANRTLVDTLFAALAADPRRRSTLPHRMCSSLRDSGGRAAFARSRTAFTAARFLAVEDDEVVLGAAEPLRRLAALCDPPATLDALAGMLAEGGSAEPDPDQVAAAAAFLRQVCDAGLLVPVEPYAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZK89</accession>
    <name>A0A7K2ZK89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS transporter subunit EIIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GT040_26655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001249">
        <property type="protein sequence ID" value="MYW32755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="15"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MYW32755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="419" mass="45183" checksum="353C49BFED129146" modified="2021-04-07" version="1">MSSSAAAAPQPKWWNGPVQGLQKVGRSLQLPVAVLPAAGLLVSLGNLLNSYLHGSFWQKTAQVLLNGGTAILDGQVGLPLLFCIGVAIGFAKKADGSTALAAVVGFLVYRGVLGAFPVDGTVTDELPVGEPQNPGVLGGILIGLLTAVVWQRYHRTKLVDWLGFFNGRRLVPILMAFLCVILGVVFGLLWQPVGDGLTWFSKQLIDLGSWGAAIFGFANRLLIPIGMHQFLNTFFWFQAGEFTGADGATVQGDISRFFAEDPSAGQFTSGFFPIMMFGLPAAALAITHCARPERRKEVGGLMVSVALTSFVTGVTEPLEFSFMFVAPLLYGVHAVLTGASMGITWLLGVHAGFSFSAGLIDYVVNWHLDTKPWLIIPIGACFAVIYYVIFRFAITKFDLKTPGREPEEIEREIEKDLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKE5</accession>
    <name>A0A7K2ZKE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dodecin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_26995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001256">
        <property type="protein sequence ID" value="MYW32822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513053.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001256.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="71" mass="7963" checksum="C0D0A700C6A45295" modified="2021-04-07" version="1">MSNHTYRVTEIVGTSEEGIDAAIRNGVARAAETLHNLDWFEINQVRGHIEDGRIAHYQVGLKVGFRLDENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKL9</accession>
    <name>A0A7K2ZKL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_27380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001275">
        <property type="protein sequence ID" value="MYW32896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW32896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="407" mass="43669" checksum="917DDE95BAD57149" modified="2021-04-07" version="1" fragment="single">PVPLTPLVGRRQALTDLSRLLANTRLVTLTGPGGVGKTRLAVAAATAERDSASQAGELVDGVWLVEFSGIRAGTPADLAQVVAATLGIRDDAPRPLPGISPFTTTPSLPHRLATALRDRRTLLVLDNCEHVVDAAAELTDLLLRTAPGLRVLATGQEPLGLAGEAMFLVEPLQPADAVRLFMERAAASTPGFPRDPDAPDEPERRAVAEICRRLDGIPLALELAATRVRALGVRELAVRLNDRFRVLTFGQRGAPARQQTLRAVIDWSWELLGAPERIVLRRLAAHTDGCDLAAAEAVCAGEGVARDEVLDLVTRLVDRSLVVVVAGPTGPRYRLLESVAAYATERLHEMEDPTAVRDRHLLHYRALAEQAEPRLRGAGQRPWLARLDAEAGNLRTALDEAVRGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZKT9</accession>
    <name>A0A7K2ZKT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_27695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001298">
        <property type="protein sequence ID" value="MYW32953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW32953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="44" mass="4469" checksum="5C80121F4D92C53B" modified="2021-04-07" version="1">AAEPAGRPGHGLVGMRERAALLGGRLTTGRGPAGGYLVEAELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLA7</accession>
    <name>A0A7K2ZLA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_28605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001328">
        <property type="protein sequence ID" value="MYW33126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="222" mass="24399" checksum="19BC5913A18A510A" modified="2021-04-07" version="1">MIQVLIVDDDVRVAEINAAYVAKVAGFRVAAQANSAAQALAVVEEVPVDLILLDHYLPDRNGLAVVRELRRLGRQVDVIMVTAARDVATVQDAMRHGALQYLVKPFTYAGLRSKLEAYAALRRTLDGGGQAEQAEVDRLFGALWAADEPELPKGHSPTTAELVRRALRDADGPLSAQEIAESAGMSRQTAQRYLKLLERTGKVRLTLRYGETGRPEHRYAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLC2</accession>
    <name>A0A7K2ZLC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional NAD(P)H-hydrate repair enzyme Nnr</fullName>
            <ecNumber evidence="9">4.2.1.136</ecNumber>
            <ecNumber evidence="8">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GT040_28690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="9"/>
    <dbReference type="EC" id="5.1.99.6" evidence="8"/>
    <dbReference type="EMBL" id="WWKE01001338">
        <property type="protein sequence ID" value="MYW33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00018591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MYW33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="144" mass="14595" checksum="A444E6AEBDC01731" modified="2021-04-07" version="1" fragment="single">GLDLVVDGITGIGGRGGLREDARALLRAVTRAHGRTPVLAVDLPSGVEADSGEVHGEAVRADATVTFGTYKPGLLIDPAAEHAGALRLVDIGLGPELPEPPDLEALQYADVAALLPVPGAESDKYSRGVVGVVAGSERYPGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLD1</accession>
    <name>A0A7K2ZLD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF485 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001328">
        <property type="protein sequence ID" value="MYW33128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="130" mass="14131" checksum="4C95C481EB20571F" modified="2021-04-07" version="1">ADGAPGPGEPPPGPGAAEIYLEVHRSAAFREVRRRYRRFVMPAALAFLLWYLAYVVVATMAPALMARPVAGAVNVAMVAGLGQFLTTFLLTWAYARHARLRRDRAALDLRWDTQEMTRGAGQPAAGGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLJ3</accession>
    <name>A0A7K2ZLJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_28950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001350">
        <property type="protein sequence ID" value="MYW33188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="162" mass="18140" checksum="6B7C542A21419079" modified="2021-04-07" version="1">MRDSVDDFLDQWAALRSDLDLEAMGAVGRLLRLTRLVDKEVGRYFAGHGMERWEFDVLATLRRSDRPLTPKELAANVMVSSAALTNRIDRLTARGLVAREAVPGDRRSLHVTLTGAGQTLVDSTVEGHVRNERRMLAELDAEDCEELNRLLRTLVNTLEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZLX7</accession>
    <name>A0A7K2ZLX7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_29780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001382">
        <property type="protein sequence ID" value="MYW33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MYW33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="408" mass="43329" checksum="C564B0A110FB788E" modified="2021-04-07" version="1">MSAATSPSERRVSARIGAISESATLAVDAKAKALKAAGRPVIGFGAGEPDFPTPGYIVDAAVEACRNPKYHRYTPAGGLPELKAAIAEKTLRDSGYEVDASQILVTNGGKQAIYEAFAAILDPGDEVIVPAPYWTTYPESIRLAGGVPVEVVADETTGYRVSVEQLEAARTEKTKVVLFVSPSNPTGAVYSEADAEAIGRWAVEHGLWVMTDEIYEHLVYGDATFTSLPAIVPELRDKCIVVNGVAKTYAMTGWRVGWIIGPKDVVKAATNLQSHATSNVSNVAQVAALAAVSGPLDAVAEMRTAFDRRRNLIVRMLNEIDGVLCPEPEGAFYAYPSVKGLLGKEIRGKRPADSVELAALILDEAEVAVVPGEAFGTPGYLRLSYALGDDDLIEGVSRLQKLLGEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZM79</accession>
    <name>A0A7K2ZM79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trxA</name>
        <name evidence="5" type="ORF">GT040_30385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001398">
        <property type="protein sequence ID" value="MYW33461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_018513042.1">
        <property type="nucleotide sequence ID" value="NZ_WWKE01001398.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="132" mass="14601" checksum="AF1F05C8449D4C57" modified="2021-04-07" version="1">MSTVELTKENFDQVVSDNGFVLIDFWASWCGPCRQFAPVYDSASERHPDLVFAKVDTEAQQELAAAFEIRSIPTLMIVRDNVAVFSQPGALPEAALEDVIGQARNLDMDEVRKSVEEQKRAAEAGQGQSEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMC1</accession>
    <name>A0A7K2ZMC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_30580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001408">
        <property type="protein sequence ID" value="MYW33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="102"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="145"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="346" mass="35864" checksum="C5B0DA0EE3B827BA" modified="2021-04-07" version="1" fragment="single">MERVRVLLVDAAPGRLLDGELERLLGHGLDVTLNLRRVADQAAVRAGWGGRVDFIDFDPFDEAALLAGTVRGGLGHDGVKSRAGVPLRAAYLAGATRAGVAHPLRVIGRAGAGTDHVDLAAAARYGVAVTHTPGSNAAAVAEFALAQLLVLTRDLRSYDEAAHRGEWRAPTAPHAELSELTLGIVGPGRIGLALAGRAGALGMDVQAFARHRGTASAPQLSPPPALRLVPTLPGLLATSDVVSLHLPLTPETRGLIGRDELALMRPGAILLNTARGGIVDEQALAEALRDPAHPLAAAAVDTFEHEHAAFASPLLGLPNALLTPHIAGMTRTAMTTAALRCADYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZMH2</accession>
    <name>A0A7K2ZMH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YihY family inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GT040_30860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001431">
        <property type="protein sequence ID" value="MYW33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MYW33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="319" mass="34435" checksum="A8158F512F6BF9F4" modified="2021-04-07" version="1">MEERAPDRPTELPRRSWTAVLRGTLKEFKDDELADRAAALTYYGVLALFPALLVLVSLLGLAGESATRQVLKNLRKLAPGSARDVISDAVEQLQGNAGVGSFMAIAGLAVAVWSASGYVAGFIRTSNAIYDMPEGRPVWKVLPLRLALTVTLMILACASALIVVFSGGLARQAGAALGIGDTPLAIWSIAKWPVLVLLVTVMIAVLYWAAPNARGRGFTWVTPGSFLALVIWLAASAGFAFYVANFASYNKTYGALAGVVVFLVWLWITNLAILLGLEFDAEMVRQRAIAGGHPKGEEPYVEPRDTRAWSDGDRRRMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZN24</accession>
    <name>A0A7K2ZN24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_31815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001448">
        <property type="protein sequence ID" value="MYW33732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="68"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="233" mass="25080" checksum="2F8CA812765AC212" modified="2021-04-07" version="1">ARLSLTDPRDLTQAISRCRWLLDLDADPVAVDDRLRTDPLLAPLVEAGPGRRVPRTVDGAEFAVRAVLGQQVSTAAARTHAARLVTAHGVEVDDPEGGLTHLFPTPEALAGLDPETLALPRTRRTTLTTLVAALADGTLHLGTGTDWERARTELSALPGFGPWTVEAIAMRALGDPDAFLPTDLGIRRAAERLGLPATPAALTARAADWRPWRAYAVQYLWTVDDHPINHLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNA7</accession>
    <name>A0A7K2ZNA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_32350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001485">
        <property type="protein sequence ID" value="MYW33835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW33835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="303" mass="34129" checksum="93E25169E1ACB49F" modified="2021-04-07" version="1">MLSTPPALIAVVGPVEPPLLAAWVRHYRSLSVERFLIAFHFPEHVAVQQQREIQAAGRELGIVPMGTSLGPWHEHTNTLLRDALRYQAGPGWHLLADTDEFQQYPVPLHEVIAQAEDSGRRVVGGLMLDRIAASGRLTDWRPHGELDTAYPFGGHLTHRLLHGDPRKIVLARHDVTVSSGNHRAPGLRPDADRICAVHHFKWRSGVLDDLRRRVQRFSTGTWQEQTPAVRDEAGRLLSHVDQHGGVINTSDQRFAFRRVSLGRLPYNWAHEARGIFTTWRPHVGNQPGFETMKAPTHSSSRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNQ4</accession>
    <name>A0A7K2ZNQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001509">
        <property type="protein sequence ID" value="MYW33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041654">
        <property type="entry name" value="StyA_sbd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17885">
        <property type="entry name" value="Smoa_sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smoa_sbd" evidence="1">
        <location>
            <begin position="146"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="411" mass="44650" checksum="58180225357CBB51" modified="2021-04-07" version="1">MRKILIVGAGQSGLQLALGLQSKGYEVTLMSNRTADEIRTGRVMSTQCMFHTALQHERDYQLNFWESQAPKIEGLGVSVAAPDSSRAIDWVGRLDGYAQSVDQRVKMAGWMETFAQRGGQLVIHGAAVSDLDYFARTYDLVMVSAGKGELVSMFGRDAARSPFDAPQRALAVAYVHGMGPRPEHPEFDAVRCNLVPGVGELFVMPTLTTSGRADILFWEGIPGGPLDAFQGIKDPSEHLAKTLELMEKFTPWEYARATKVELTDANGTLAGRYAPTVRKPIGRLPGGGLVLGVADVVVANDPITGQGSNSASKCANSYLDSILAHGDKEFDATWMQSTFDRYWETAQHVTKWTNAMLGVPPEHVLNLIGAAGQLQPVADRFANGFNDPADFDNFFFEPEKTNAYLASVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZNW8</accession>
    <name>A0A7K2ZNW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholesterol esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GT040_33530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001540">
        <property type="protein sequence ID" value="MYW34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046198">
        <property type="entry name" value="DUF6230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19741">
        <property type="entry name" value="DUF6230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029495964" evidence="1">
        <location>
            <begin position="39"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MYW34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="216" mass="22388" checksum="0E8A921A7DDA2383" modified="2021-04-07" version="1">MSSQVRGGTRWKRFALVMVPSVVATAAVGVGLAQGALAASFSVSGQSFKVSTDELDGQNFVQYGSVAVGKDLEGKDAAHAVAVSGFSSAKITNMCQSVVTPKVPGIGNVSLQLRAGTNPDKPVLATNLYLDVAQLDADAAFENIDIGVATGSLKQEGKKGSIGVQPGTQAKSEGFAQRADRAVLTKVEQTAWATTAGTFKLSDLKLRLHTGVKECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZP06</accession>
    <name>A0A7K2ZP06_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ORF">GT040_33610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SID2119</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="WWKE01001541">
        <property type="protein sequence ID" value="MYW34077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="65"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="304"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MYW34077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="412" mass="43543" checksum="C7EEC60CC382E0C9" modified="2021-04-07" version="1">MAGNTEPLSPRAKLAVTAGKAAAAVSRAAGRGSGSVIGGRVALKLDPDLLGRLAQHLDVILVSATNGKTTTTRLIAEALGAAGPVVSNALGANMPAGITSALAGGSDAKFGVIEVDEKYLAGVARDTTPKAIALLNLSRDQLDRAAETRMMAEHWREGLSGSKAVIIANADDPLVVWAASSSPNVVWVAAGQAWKDDAWSCPSCGGVMQRPGEDWFCGQCGFRRPAPSWALNGDYVLDPHGSAWPIHLQLPGRANKANAASSAAVAAVFGVPPQVALERMYQVQAVAGRYDVVTFNNRELRLLLAKNPAGWLETFSLIDPPPTPVILSVNARGADGTDTSWLWDVDYTQLAGHPIFVLGDRKLDLAVRLEVAGLDFRVCENLDEAVQYAPPGRIEVIANYTAFQDLRRRVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPB0</accession>
    <name>A0A7K2ZPB0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GT040_34075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SID2119</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001552">
        <property type="protein sequence ID" value="MYW34170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MYW34170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="257" mass="26937" checksum="1B709DFDAD8A5BD5" modified="2021-04-07" version="1">MGRAPGPLTHASVMAGRSLRVSLRNSDALIMSLALPIMLMLIFVYFFGGAIETGAAHDSYVMYVVPGVLLLCAGFGAATTATAVSEDMKGGIIDRFRSLDVGGTPVLAGHVAASTVRNLFATVLVFGVAVLIGFRPAASWSGWLLVAAVLIAYIVALSWISAAIGLLARSPEAASGFTFFMSFLPYPSSAFAPIEKMPDWLHGFARNQPITPAIESLRGLLLGEPVGDAPWIALAWAGGMLAVAIAASGVLFRIRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPG5</accession>
    <name>A0A7K2ZPG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GT040_34405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001579">
        <property type="protein sequence ID" value="MYW34230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000462206">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MYW34230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000462206"/>
        </source>
    </evidence>
    <sequence length="95" mass="9564" checksum="E7646CAACB8693AD" modified="2021-04-07" version="1" fragment="single">ARAEAGSAVWTELATGALGGAQAPEADPEQVAAEAVDVTLPEEYAPEAGVFGLHPELLRAALAAAPDATAGATLVDAEWRGVRLYAPGATAVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-04-07" modified="2021-09-29" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7K2ZPH5</accession>
    <name>A0A7K2ZPH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GT040_34615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces sp. SID2119</name>
        <dbReference type="NCBI Taxonomy" id="2690253"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="516" last="516">
            <title>The antimicrobial potential of Streptomyces from insect microbiomes.</title>
            <authorList>
                <person name="Chevrette M.G."/>
                <person name="Carlson C.M."/>
                <person name="Ortega H.E."/>
                <person name="Thomas C."/>
                <person name="Ananiev G.E."/>
                <person name="Barns K.J."/>
                <person name="Book A.J."/>
                <person name="Cagnazzo J."/>
                <person name="Carlos C."/>
                <person name="Flanigan W."/>
                <person name="Grubbs K.J."/>
                <person name="Horn H.A."/>
                <person name="Hoffmann F.M."/>
                <person name="Klassen J.L."/>
                <person name="Knack J.J."/>
                <person name="Lewin G.R."/>
                <person name="McDonald B.R."/>
                <person name="Muller L."/>
                <person name="Melo W.G.P."/>
                <person name="Pinto-Tomas A.A."/>
                <person name="Schmitz A."/>
                <person name="Wendt-Pienkowski E."/>
                <person name="Wildman S."/>
                <person name="Zhao M."/>
                <person name="Zhang F."/>
                <person name="Bugni T.S."/>
                <person name="Andes D.R."/>
                <person name="Pupo M.T."/>
                <person name="Currie C.R."/>
            </authorList>
            <dbReference type="PubMed" id="30705269"/>
            <dbReference type="DOI" id=".1038/s41467-019-08438-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SID2119</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="WWKE01001586">
       
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